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Conserved domains on  [gi|493711092|ref|WP_006660728|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Providencia]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-105 2.69e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.42  E-value: 2.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493711092  15 AMTQAATQTASLLKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKL 94
Cdd:COG0640    2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                         90
                 ....*....|.
gi 493711092  95 FILLNTLYQLY 105
Cdd:COG0640   82 AELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-105 2.69e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.42  E-value: 2.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493711092  15 AMTQAATQTASLLKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKL 94
Cdd:COG0640    2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                         90
                 ....*....|.
gi 493711092  95 FILLNTLYQLY 105
Cdd:COG0640   82 AELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 24-98 1.59e-26

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 93.29  E-value: 1.59e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493711092  24 ASLLKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKLFILL 98
Cdd:NF033788   2 AELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
38-101 6.46e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.09  E-value: 6.46e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493711092    38 LLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKLFILLNTL 101
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 27-101 2.20e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.41  E-value: 2.20e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493711092  27 LKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIAD-EKLFILLNTL 101
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 32-76 2.55e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 493711092   32 NPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELV 76
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 22-90 3.29e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.89  E-value: 3.29e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493711092  22 QTASLLKTLGNPDRLLLLCQLTQ-GEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIA 90
Cdd:PRK10141   5 LPLQLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLS 74
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-105 2.69e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.42  E-value: 2.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493711092  15 AMTQAATQTASLLKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKL 94
Cdd:COG0640    2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                         90
                 ....*....|.
gi 493711092  95 FILLNTLYQLY 105
Cdd:COG0640   82 AELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 24-98 1.59e-26

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 93.29  E-value: 1.59e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493711092  24 ASLLKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKLFILL 98
Cdd:NF033788   2 AELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
38-101 6.46e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.09  E-value: 6.46e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493711092    38 LLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADEKLFILLNTL 101
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 27-101 2.20e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.41  E-value: 2.20e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493711092  27 LKTLGNPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIAD-EKLFILLNTL 101
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 32-76 2.55e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 493711092   32 NPDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELV 76
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 22-90 3.29e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.89  E-value: 3.29e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493711092  22 QTASLLKTLGNPDRLLLLCQLTQ-GEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIA 90
Cdd:PRK10141   5 LPLQLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLS 74
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
33-92 5.59e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 42.56  E-value: 5.59e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493711092  33 PDRLLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGKRIYYSIADE 92
Cdd:COG3398   98 TPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 24-83 8.17e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 37.52  E-value: 8.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493711092   24 ASLLKTLGNPDRLLLLCQLTQGE-ACVSDLEASLGIQQPTLSQQLTVLRNEELVATRREGK 83
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK09775 PRK09775
type II toxin-antitoxin system HipA family toxin YjjJ;
36-92 2.42e-04

type II toxin-antitoxin system HipA family toxin YjjJ;


Pssm-ID: 236623 [Multi-domain]  Cd Length: 442  Bit Score: 38.79  E-value: 2.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 493711092  36 LLLLCQLTQGEACVSDLEASLGIQQPTLSQQLTVLRNEelVATRREGKRIYYSIADE 92
Cdd:PRK09775   3 SLLTTLLLQGPLSAAELAARLGVSQATLSRLLAALGDQ--VVRFGKARATRYALLRP 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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