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Conserved domains on  [gi|493749102|ref|WP_006698082|]
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MULTISPECIES: PAS domain-containing protein [Rhizobium/Agrobacterium group]

Protein Classification

PAS domain-containing protein( domain architecture ID 12091914)

PAS domain-containing protein binds ligand(s) and may act as sensors for light and oxygen in signal transduction; similar to Homo sapiens endothelial PAS domain-containing protein 1

CATH:  3.30.450.20
Gene Ontology:  GO:0005515|GO:0007165
PubMed:  15009198|33647528|16939366|10357859|9382818|21663441
SCOP:  3000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 44-113 8.41e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


:

Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 54.27  E-value: 8.41e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493749102   44 GIPVEDFIAQIESGS-------RARVAEAVYNSLTNGVFYDQEYRIQLTSGGFRWLRTTGRVILDSDRLPIMAMGTV 113
Cdd:pfam08447  13 GYTPEELLGKGESWLdlvhpddRERVREALWEALKGGEPYSGEYRIRRKDGEYRWVEARARPIRDENGKPVRVIGVA 89
 
Name Accession Description Interval E-value
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 44-113 8.41e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 54.27  E-value: 8.41e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493749102   44 GIPVEDFIAQIESGS-------RARVAEAVYNSLTNGVFYDQEYRIQLTSGGFRWLRTTGRVILDSDRLPIMAMGTV 113
Cdd:pfam08447  13 GYTPEELLGKGESWLdlvhpddRERVREALWEALKGGEPYSGEYRIRRKDGEYRWVEARARPIRDENGKPVRVIGVA 89
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 12-116 2.70e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 43.01  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102  12 VGYYTWNIGQNLVYLDAVAARLREVRPEKAaRGIPVEDFIaqiESGSRARVAEAVYNSLTNGVFYDQEYRIQLTSGGFRW 91
Cdd:cd00130    3 DGVIVLDLDGRILYANPAAEQLLGYSPEEL-IGKSLLDLI---HPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIW 78

                         90       100
                 ....*....|....*....|....*
gi 493749102  92 LRTTGRVILDSDRLPIMAMGTVRDI 116
Cdd:cd00130   79 VLVSLTPIRDEGGEVIGLLGVVRDI 103
PAC smart00086
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...
 77-118 1.31e-04

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.


Pssm-ID: 197509  Cd Length: 43  Bit Score: 36.78  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 493749102    77 DQEYRIQLTSGGFRWLRTTGRVILDSDRLPIMAMGTVRDISA 118
Cdd:smart00086   1 TVEYRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDITE 42
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 12-122 1.49e-04

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 40.04  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102   12 VGYYTWNIGQNLVYLDAVAARLREVRPEKAARgipVEDFIAQIESGSRARVAEAVYNSLTNGVFYDQEYRIQLtSGGFRW 91
Cdd:PRK09776  421 IGIWEWDLKPNIISWDKRMFELYEIPPHIKPT---WQVWYACLHPEDRQRVEKEIRDALQGRSPFKLEFRIVV-KDGVRH 496

                          90       100       110
                  ....*....|....*....|....*....|.
gi 493749102   92 LRTTGRVILDSDRLPIMAMGTVRDISAGKLL 122
Cdd:PRK09776  497 IRALANRVLNKDGEVERLLGINMDMTEVRQL 527
PAS COG2202
PAS domain [Signal transduction mechanisms];
7-118 1.41e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 36.93  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102   7 LEETLVGYYTWNIGQNLVYLDAVAARLREVRPEkAARGIPVEDFIAQIEsgsRARVAEAVYNSLTNGVFYDQEYRIQLTS 86
Cdd:COG2202   17 VESSPDAIIITDLDGRILYVNPAFERLTGYSAE-ELLGKTLRDLLPPED---DDEFLELLRAALAGGGVWRGELRNRRKD 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 493749102  87 GGFRWLRTTGRVILDSDRLPIMAMGTVRDISA 118
Cdd:COG2202   93 GSLFWVELSISPVRDEDGEITGFVGIARDITE 124
 
Name Accession Description Interval E-value
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 44-113 8.41e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 54.27  E-value: 8.41e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493749102   44 GIPVEDFIAQIESGS-------RARVAEAVYNSLTNGVFYDQEYRIQLTSGGFRWLRTTGRVILDSDRLPIMAMGTV 113
Cdd:pfam08447  13 GYTPEELLGKGESWLdlvhpddRERVREALWEALKGGEPYSGEYRIRRKDGEYRWVEARARPIRDENGKPVRVIGVA 89
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 12-116 2.70e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 43.01  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102  12 VGYYTWNIGQNLVYLDAVAARLREVRPEKAaRGIPVEDFIaqiESGSRARVAEAVYNSLTNGVFYDQEYRIQLTSGGFRW 91
Cdd:cd00130    3 DGVIVLDLDGRILYANPAAEQLLGYSPEEL-IGKSLLDLI---HPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIW 78

                         90       100
                 ....*....|....*....|....*
gi 493749102  92 LRTTGRVILDSDRLPIMAMGTVRDI 116
Cdd:cd00130   79 VLVSLTPIRDEGGEVIGLLGVVRDI 103
PAC smart00086
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...
 77-118 1.31e-04

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.


Pssm-ID: 197509  Cd Length: 43  Bit Score: 36.78  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 493749102    77 DQEYRIQLTSGGFRWLRTTGRVILDSDRLPIMAMGTVRDISA 118
Cdd:smart00086   1 TVEYRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDITE 42
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 12-122 1.49e-04

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 40.04  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102   12 VGYYTWNIGQNLVYLDAVAARLREVRPEKAARgipVEDFIAQIESGSRARVAEAVYNSLTNGVFYDQEYRIQLtSGGFRW 91
Cdd:PRK09776  421 IGIWEWDLKPNIISWDKRMFELYEIPPHIKPT---WQVWYACLHPEDRQRVEKEIRDALQGRSPFKLEFRIVV-KDGVRH 496

                          90       100       110
                  ....*....|....*....|....*....|.
gi 493749102   92 LRTTGRVILDSDRLPIMAMGTVRDISAGKLL 122
Cdd:PRK09776  497 IRALANRVLNKDGEVERLLGINMDMTEVRQL 527
PAS COG2202
PAS domain [Signal transduction mechanisms];
7-118 1.41e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 36.93  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102   7 LEETLVGYYTWNIGQNLVYLDAVAARLREVRPEkAARGIPVEDFIAQIEsgsRARVAEAVYNSLTNGVFYDQEYRIQLTS 86
Cdd:COG2202   17 VESSPDAIIITDLDGRILYVNPAFERLTGYSAE-ELLGKTLRDLLPPED---DDEFLELLRAALAGGGVWRGELRNRRKD 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 493749102  87 GGFRWLRTTGRVILDSDRLPIMAMGTVRDISA 118
Cdd:COG2202   93 GSLFWVELSISPVRDEDGEITGFVGIARDITE 124
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 12-116 2.93e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 35.09  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102   12 VGYYTWNIGQNLVYLDAVAARLREVRPEkAARGIPVEDFIAQIESGSRARVAEAVYNSLTNGVfyDQEYRIQLTSGGFRW 91
Cdd:pfam00989  12 DGIFVVDEDGRILYVNAAAEELLGLSRE-EVIGKSLLDLIPEEDDAEVAELLRQALLQGEESR--GFEVSFRVPDGRPRH 88

                          90       100
                  ....*....|....*....|....*
gi 493749102   92 LRTTGRVILDSDRLPIMAMGTVRDI 116
Cdd:pfam00989  89 VEVRASPVRDAGGEILGFLGVLRDI 113
PAS COG2202
PAS domain [Signal transduction mechanisms];
7-122 3.46e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 35.77  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493749102   7 LEETLVGYYTWNIGQNLVYLDAVAARLREVRPEkAARGIPVEDFIAQIEsgsRARVAEAVYNSLTNGV-FYDQEYRIQLT 85
Cdd:COG2202  143 VENAPDGIFVLDLDGRILYVNPAAEELLGYSPE-ELLGKSLLDLLHPED---RERLLELLRRLLEGGReSYELELRLKDG 218

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 493749102  86 SGGFRWLRTTGRVILDSDRlPIMAMGTVRDISAGKLL 122
Cdd:COG2202  219 DGRWVWVEASAVPLRDGGE-VIGVLGIVRDITERKRA 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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