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Conserved domains on  [gi|493782265|ref|WP_006730645|]
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folate family ECF transporter S component [Lactobacillus iners]

Protein Classification

folate family ECF transporter S component( domain architecture ID 10025283)

folate family ECF transporter S component similar to folate transporter FolT, the membrane-embedded folate-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex to facilitate folate transport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECF_S_folT_fam TIGR04518
ECF transporter S component, folate family; Members of this model are the multiple ...
 5-162 2.20e-27

ECF transporter S component, folate family; Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate]


:

Pssm-ID: 275311 [Multi-domain]  Cd Length: 162  Bit Score: 100.72  E-value: 2.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265    5 NLKIQKMVVLAMLIALYIIFSRLLSLNIGgSHKISFTFICIALMGCLYSPYVTAISCAGADFIGCMLFPKLTYFPGFTLT 84
Cdd:TIGR04518   1 KFTVKNLTILALLVALSIILSRFLSIQTG-NLRISFGFLPVILAGMLFGPVAGAIVGAVADLLGCMLFGYGTFFPGFTLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265   85 AFLVGLVFGIVFSNKVN---FVRILIATGL-TCLIQFFVNSFWLKIICHVPYSVMLISRIPQECIMAVVMVILLSALFKL 160
Cdd:TIGR04518  80 AALTGLIYGLFFYKKKNkklFLRLAAAVVIvQIIISLVLTSIWLSILYGSPLTALLPIRLIKAIIMIPVEIVVIYLLLKN 159


                  ..
gi 493782265  161 DI 162
Cdd:TIGR04518 160 LA 161
 
Name Accession Description Interval E-value
ECF_S_folT_fam TIGR04518
ECF transporter S component, folate family; Members of this model are the multiple ...
 5-162 2.20e-27

ECF transporter S component, folate family; Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275311 [Multi-domain]  Cd Length: 162  Bit Score: 100.72  E-value: 2.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265    5 NLKIQKMVVLAMLIALYIIFSRLLSLNIGgSHKISFTFICIALMGCLYSPYVTAISCAGADFIGCMLFPKLTYFPGFTLT 84
Cdd:TIGR04518   1 KFTVKNLTILALLVALSIILSRFLSIQTG-NLRISFGFLPVILAGMLFGPVAGAIVGAVADLLGCMLFGYGTFFPGFTLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265   85 AFLVGLVFGIVFSNKVN---FVRILIATGL-TCLIQFFVNSFWLKIICHVPYSVMLISRIPQECIMAVVMVILLSALFKL 160
Cdd:TIGR04518  80 AALTGLIYGLFFYKKKNkklFLRLAAAVVIvQIIISLVLTSIWLSILYGSPLTALLPIRLIKAIIMIPVEIVVIYLLLKN 159


                  ..
gi 493782265  161 DI 162
Cdd:TIGR04518 160 LA 161
ECF_trnsprt pfam12822
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 9-158 1.01e-04

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


Pssm-ID: 432808  Cd Length: 157  Bit Score: 40.75  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265    9 QKMVVLAMLIALYIIFSrLLSLNIGGSHKISFTFICIALMGCLYSPYVTAISCAGADFIGCML--FPKLTYFPGFTLTAF 86
Cdd:pfam12822   1 KRLVIIALLSALSIVLM-FTPPFPPIPLKIDLSHIPALLGALLLGPLAGILIGLLTSLLSALTtgGGGPTGEPANFLPGI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493782265   87 LVGLVFGIVFSNKVN------FVRILIATGLTCLIQFFVNSFWLKIICHVPYSVMLISRIPQECIMAVVMVILLSALF 158
Cdd:pfam12822  80 LIGLVAGYLYKYGRNkkkkriLLALILGTILGTLVATLLNLLLILPFGPLLFAALLLPVLPFNLIEGIIAAILVPVLY 157
 
Name Accession Description Interval E-value
ECF_S_folT_fam TIGR04518
ECF transporter S component, folate family; Members of this model are the multiple ...
 5-162 2.20e-27

ECF transporter S component, folate family; Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275311 [Multi-domain]  Cd Length: 162  Bit Score: 100.72  E-value: 2.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265    5 NLKIQKMVVLAMLIALYIIFSRLLSLNIGgSHKISFTFICIALMGCLYSPYVTAISCAGADFIGCMLFPKLTYFPGFTLT 84
Cdd:TIGR04518   1 KFTVKNLTILALLVALSIILSRFLSIQTG-NLRISFGFLPVILAGMLFGPVAGAIVGAVADLLGCMLFGYGTFFPGFTLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265   85 AFLVGLVFGIVFSNKVN---FVRILIATGL-TCLIQFFVNSFWLKIICHVPYSVMLISRIPQECIMAVVMVILLSALFKL 160
Cdd:TIGR04518  80 AALTGLIYGLFFYKKKNkklFLRLAAAVVIvQIIISLVLTSIWLSILYGSPLTALLPIRLIKAIIMIPVEIVVIYLLLKN 159


                  ..
gi 493782265  161 DI 162
Cdd:TIGR04518 160 LA 161
ECF_trnsprt pfam12822
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 9-158 1.01e-04

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


Pssm-ID: 432808  Cd Length: 157  Bit Score: 40.75  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493782265    9 QKMVVLAMLIALYIIFSrLLSLNIGGSHKISFTFICIALMGCLYSPYVTAISCAGADFIGCML--FPKLTYFPGFTLTAF 86
Cdd:pfam12822   1 KRLVIIALLSALSIVLM-FTPPFPPIPLKIDLSHIPALLGALLLGPLAGILIGLLTSLLSALTtgGGGPTGEPANFLPGI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493782265   87 LVGLVFGIVFSNKVN------FVRILIATGLTCLIQFFVNSFWLKIICHVPYSVMLISRIPQECIMAVVMVILLSALF 158
Cdd:pfam12822  80 LIGLVAGYLYKYGRNkkkkriLLALILGTILGTLVATLLNLLLILPFGPLLFAALLLPVLPFNLIEGIIAAILVPVLY 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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