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Conserved domains on  [gi|493833878|ref|WP_006781138|]
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phosphopyruvate hydratase [Hungatella hathewayi]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 6-421 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 828.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   6 EIIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGG-RRYHGLGVKKAVEHVNTILAEAIMFE 84
Cdd:COG0148    3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIGM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  85 NALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDL 164
Cdd:COG0148   83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNVDI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 165 QEFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAID 244
Cdd:COG0148  163 QEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALALD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 245 AASSELYNEesGMYVFPGESQmsgiqvERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDL 324
Cdd:COG0148  243 VAASEFYKD--GKYHLKGEGK------ELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 325 FVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCR 404
Cdd:COG0148  315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                        410
                 ....*....|....*..
gi 493833878 405 SDRVAKYNQLLRIEENL 421
Cdd:COG0148  395 SERVAKYNQLLRIEEEL 411
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 6-421 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 828.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   6 EIIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGG-RRYHGLGVKKAVEHVNTILAEAIMFE 84
Cdd:COG0148    3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIGM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  85 NALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDL 164
Cdd:COG0148   83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNVDI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 165 QEFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAID 244
Cdd:COG0148  163 QEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALALD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 245 AASSELYNEesGMYVFPGESQmsgiqvERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDL 324
Cdd:COG0148  243 VAASEFYKD--GKYHLKGEGK------ELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 325 FVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCR 404
Cdd:COG0148  315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                        410
                 ....*....|....*..
gi 493833878 405 SDRVAKYNQLLRIEENL 421
Cdd:COG0148  395 SERVAKYNQLLRIEEEL 411
eno PRK00077
enolase; Provisional
 6-424 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 803.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   6 EIIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGGR-RYHGLGVKKAVEHVNTILAEAIMFE 84
Cdd:PRK00077   3 KIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKsRYLGKGVLKAVENVNEEIAPALIGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  85 NALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDL 164
Cdd:PRK00077  83 DALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNVDI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 165 QEFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAID 244
Cdd:PRK00077 163 QEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALALD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 245 AASSELYneESGMYVFPGEsqmsgiqvERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDL 324
Cdd:PRK00077 243 CAASEFY--KDGKYVLEGE--------GLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 325 FVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCR 404
Cdd:PRK00077 313 FVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSR 392

                        410       420
                 ....*....|....*....|
gi 493833878 405 SDRVAKYNQLLRIEENLYAK 424
Cdd:PRK00077 393 SERIAKYNQLLRIEEELGDA 412
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 10-419 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 726.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  10 VQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGG-RRYHGLGVKKAVEHVNTILAEAIMFENALD 88
Cdd:cd03313    2 IKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDkSRYLGKGVLKAVKNVNEIIAPALIGMDVTD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  89 QRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDLQEFM 168
Cdd:cd03313   82 QRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEFM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 169 IMPVGAESFSEGLQMCAEIYHTLKKILKA--GGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAIDAA 246
Cdd:cd03313  162 IVPVGAPSFSEALRMGAEVYHTLKKVLKKkgGLLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 247 SSELYNEESGMYVFPGesqmsgiQVERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDLFV 326
Cdd:cd03313  242 ASEFYDEGKYVYDSDE-------GKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 327 TNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCRSD 406
Cdd:cd03313  315 TNPERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSE 394

                        410
                 ....*....|...
gi 493833878 407 RVAKYNQLLRIEE 419
Cdd:cd03313  395 RTAKYNQLLRIEE 407
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 7-421 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 687.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878    7 IIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGGR-RYHGLGVKKAVEHVNTILAEAIMFEN 85
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKkRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   86 ALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDLQ 165
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  166 EFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAIDA 245
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  246 ASSELYNEESGMYVFPGESqmsgiqVERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDLF 325
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGEN------KQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  326 VTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCRS 405
Cdd:TIGR01060 315 VTNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRS 394

                         410
                  ....*....|....*.
gi 493833878  406 DRVAKYNQLLRIEENL 421
Cdd:TIGR01060 395 ERIAKYNQLLRIEEEL 410
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
141-421 4.60e-150

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 427.28  E-value: 4.60e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  141 AHELPVPMMNILNGGVHADNTVDLQEFMIMPVGAESFSEGLQMCAEIYHTLKKILKA--GGYATAVGDEGGFAPNLKNTE 218
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAkyGQSATNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  219 EVLSYIVDAIKLSGYEAgtQVKIAIDAASSELYNEESGMYVFPGESQMSGIQVERTAEEMVDYYLRLVDGFPIISIEDGL 298
Cdd:pfam00113  81 EALDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGEKSDKSKKLTSAQLADLYEELVKKYPIVSIEDPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  299 QEEDWEGWQLMTKKLGHRVQLVGDDLFVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSG 378
Cdd:pfam00113 159 DEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 493833878  379 ETEDSIIADIAVAVNSGQIKTGAPCRSDRVAKYNQLLRIEENL 421
Cdd:pfam00113 239 ETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEEL 281
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 6-421 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 828.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   6 EIIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGG-RRYHGLGVKKAVEHVNTILAEAIMFE 84
Cdd:COG0148    3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIGM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  85 NALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDL 164
Cdd:COG0148   83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNVDI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 165 QEFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAID 244
Cdd:COG0148  163 QEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALALD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 245 AASSELYNEesGMYVFPGESQmsgiqvERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDL 324
Cdd:COG0148  243 VAASEFYKD--GKYHLKGEGK------ELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 325 FVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCR 404
Cdd:COG0148  315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                        410
                 ....*....|....*..
gi 493833878 405 SDRVAKYNQLLRIEENL 421
Cdd:COG0148  395 SERVAKYNQLLRIEEEL 411
eno PRK00077
enolase; Provisional
 6-424 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 803.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   6 EIIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGGR-RYHGLGVKKAVEHVNTILAEAIMFE 84
Cdd:PRK00077   3 KIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKsRYLGKGVLKAVENVNEEIAPALIGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  85 NALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDL 164
Cdd:PRK00077  83 DALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNVDI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 165 QEFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAID 244
Cdd:PRK00077 163 QEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALALD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 245 AASSELYneESGMYVFPGEsqmsgiqvERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDL 324
Cdd:PRK00077 243 CAASEFY--KDGKYVLEGE--------GLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 325 FVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCR 404
Cdd:PRK00077 313 FVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSR 392

                        410       420
                 ....*....|....*....|
gi 493833878 405 SDRVAKYNQLLRIEENLYAK 424
Cdd:PRK00077 393 SERIAKYNQLLRIEEELGDA 412
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 10-419 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 726.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  10 VQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGG-RRYHGLGVKKAVEHVNTILAEAIMFENALD 88
Cdd:cd03313    2 IKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDkSRYLGKGVLKAVKNVNEIIAPALIGMDVTD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  89 QRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDLQEFM 168
Cdd:cd03313   82 QRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEFM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 169 IMPVGAESFSEGLQMCAEIYHTLKKILKA--GGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAIDAA 246
Cdd:cd03313  162 IVPVGAPSFSEALRMGAEVYHTLKKVLKKkgGLLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 247 SSELYNEESGMYVFPGesqmsgiQVERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDLFV 326
Cdd:cd03313  242 ASEFYDEGKYVYDSDE-------GKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 327 TNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCRSD 406
Cdd:cd03313  315 TNPERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSE 394

                        410
                 ....*....|...
gi 493833878 407 RVAKYNQLLRIEE 419
Cdd:cd03313  395 RTAKYNQLLRIEE 407
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 7-421 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 687.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878    7 IIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDGGR-RYHGLGVKKAVEHVNTILAEAIMFEN 85
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKkRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   86 ALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNGGVHADNTVDLQ 165
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  166 EFMIMPVGAESFSEGLQMCAEIYHTLKKILKAGGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAGTQVKIAIDA 245
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  246 ASSELYNEESGMYVFPGESqmsgiqVERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLGHRVQLVGDDLF 325
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGEN------KQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  326 VTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGAPCRS 405
Cdd:TIGR01060 315 VTNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRS 394

                         410
                  ....*....|....*.
gi 493833878  406 DRVAKYNQLLRIEENL 421
Cdd:TIGR01060 395 ERIAKYNQLLRIEEEL 410
PTZ00081 PTZ00081
enolase; Provisional
 7-424 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 552.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   7 IIGVQGREILDSRGNPTVEVEVQLEGGaVGRAAVPSGASTGKFEAVELRDGG-RRYHGLGVKKAVEHVNTILAEAIMFEN 85
Cdd:PTZ00081   4 IKSIKAREILDSRGNPTVEVDLTTEKG-VFRAAVPSGASTGIYEALELRDGDkSRYLGKGVLKAVENVNEIIAPALIGKD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  86 ALDQRHIDRLLREA-DGTEN-----KENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHE-----LPVPMMNILNG 154
Cdd:PTZ00081  83 VTDQKKLDKLMVEQlDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKPtdkfvLPVPCFNVING 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 155 GVHADNTVDLQEFMIMPVGAESFSEGLQMCAEIYHTLKKILKA--GGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSG 232
Cdd:PTZ00081 163 GKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKkyGLDATNVGDEGGFAPNIKDPEEALDLLVEAIKKAG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 233 YEAgtQVKIAIDAASSELYNEESGMYVFPGESQMSGIQVERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKK 312
Cdd:PTZ00081 243 YEG--KVKICMDVAASEFYDKEKKVYDLDFKNPNNDKSNKLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAKLTAA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 313 LGHRVQLVGDDLFVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAV 392
Cdd:PTZ00081 321 IGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLVVGL 400

                        410       420       430
                 ....*....|....*....|....*....|..
gi 493833878 393 NSGQIKTGAPCRSDRVAKYNQLLRIEENLYAK 424
Cdd:PTZ00081 401 GTGQIKTGAPCRSERLAKYNQLLRIEEELGSN 432
PLN00191 PLN00191
enolase
 7-421 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 526.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   7 IIGVQGREILDSRGNPTVEVEVQLEGGaVGRAAVPSGASTGKFEAVELRDGGRRYHGLGVKKAVEHVNTILAEAIMFENA 86
Cdd:PLN00191  28 ITKVKARQIIDSRGNPTVEVDLHTSKG-MFRAAVPSGASTGIYEALELRDGDKDYLGKGVLKAVKNVNEIIAPALIGMDP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  87 LDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRY---LGGIGAHELPVPMMNILNGGVHADNTVD 163
Cdd:PLN00191 107 TDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHiadLAGNKKLVLPVPAFNVINGGSHAGNKLA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 164 LQEFMIMPVGAESFSEGLQMCAEIYHTLKKILKA--GGYATAVGDEGGFAPNLKNTEEVLSYIVDAIKLSGYEAgtQVKI 241
Cdd:PLN00191 187 MQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKkyGQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYTG--KIKI 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 242 AIDAASSELYNEEsGMYVFPGESQMSGIQVERTAEEMVDYYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLghRVQLVG 321
Cdd:PLN00191 265 GMDVAASEFYTKD-KKYDLDFKEENNDGSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSLE--DVQIVG 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 322 DDLFVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSGETEDSIIADIAVAVNSGQIKTGA 401
Cdd:PLN00191 342 DDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQIKTGA 421

                        410       420
                 ....*....|....*....|
gi 493833878 402 PCRSDRVAKYNQLLRIEENL 421
Cdd:PLN00191 422 PCRSERLAKYNQLLRIEEEL 441
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
141-421 4.60e-150

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 427.28  E-value: 4.60e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  141 AHELPVPMMNILNGGVHADNTVDLQEFMIMPVGAESFSEGLQMCAEIYHTLKKILKA--GGYATAVGDEGGFAPNLKNTE 218
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAkyGQSATNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  219 EVLSYIVDAIKLSGYEAgtQVKIAIDAASSELYNEESGMYVFPGESQMSGIQVERTAEEMVDYYLRLVDGFPIISIEDGL 298
Cdd:pfam00113  81 EALDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGEKSDKSKKLTSAQLADLYEELVKKYPIVSIEDPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  299 QEEDWEGWQLMTKKLGHRVQLVGDDLFVTNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHRSG 378
Cdd:pfam00113 159 DEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 493833878  379 ETEDSIIADIAVAVNSGQIKTGAPCRSDRVAKYNQLLRIEENL 421
Cdd:pfam00113 239 ETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEEL 281
Enolase_N pfam03952
Enolase, N-terminal domain;
7-136 8.86e-81

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 244.59  E-value: 8.86e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878    7 IIGVQGREILDSRGNPTVEVEVQLEGGAVGRAAVPSGASTGKFEAVELRDG-GRRYHGLGVKKAVEHVNTILAEAIMFEN 85
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGdKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 493833878   86 ALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYL 136
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
PRK08350 PRK08350
hypothetical protein; Provisional
 7-154 2.75e-16

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 79.46  E-value: 2.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   7 IIGVQGREILDSRGNPTVEVEVQLEGGaVGRAAVPSgastgkfeavelrDGGRRYHGLGVKKAVEHVNTILAEAIMFENA 86
Cdd:PRK08350   4 IENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPI-------------DENPSLYIAEAHRAVSEVDEIIGPELIGFDA 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493833878  87 LDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGIGAHELPVPMMNILNG 154
Cdd:PRK08350  70 SEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTTELPVPILEFAED 137
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 217-393 1.25e-11

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 63.89  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 217 TEEVLSYIVDAIklsgyeaGTQVKIAIDAASSElyneesgmyvfpgesqmsgiqverTAEEMVDYYlRLVDGFPIISIED 296
Cdd:cd00308   80 SIERVRAVREAF-------GPDARLAVDANGAW------------------------TPKEAIRLI-RALEKYGLAWIEE 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 297 GLQEEDWEGWQLMTKKLGhrVQLVGDDLFVTNTKRLkKGIELGAANSILVKVNQIGTLSESFDAIEMAKQAGYTTVISHR 376
Cdd:cd00308  128 PCAPDDLEGYAALRRRTG--IPIAADESVTTVDDAL-EALELGAVDILQIKPTRVGGLTESRRAADLAEAFGIRVMVHGT 204

                        170
                 ....*....|....*...
gi 493833878 377 SG-ETEDSIIADIAVAVN 393
Cdd:cd00308  205 LEsSIGTAAALHLAAALP 222
PTZ00378 PTZ00378
hypothetical protein; Provisional
 6-366 9.75e-07

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 51.03  E-value: 9.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878   6 EIIGVQGREILDSRGNPTVEVEVQLEGGAvgraAVPSGASTGKfeAVELRDGGRRyHGLGVKKAVEHV--NTILAEAIMF 83
Cdd:PTZ00378  50 EIRALVHNEVLSPAGETVLRFTLELLNGM----EVSSGALLSP--SHGERDGEAD-ATLDPAEYTTEAlqNSYFPRLLQL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  84 eNALDQRHIDRLLREADGTENKENMGANAILGVSMAVARAAANGLEMPLYRYLGGI-----GAHELPVPMMNI--LNGGV 156
Cdd:PTZ00378 123 -GARDQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRSVPLFQYLRALfgsltSVETFSMPQLCItfFGPGN 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 157 HADNTVDLQEFMIMPVgaesFSEGlqmcAEIYHTLKKILKAG-----GYATAVGDEGGFA-PNLKNTEEVLSYIVDAIKL 230
Cdd:PTZ00378 202 PSTARLALKSVLFSPV----MPSG----TVLRERMQKIFAAFhhfcqSHNSSVRSDGSLHwDGFANLTDAVKLATEALRA 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 231 SGYEAGTQVKI------------AIDAASSELYNEESG----MY-VFPGESQMSGIQVertaEEMVDYYLRLVDGFpIIS 293
Cdd:PTZ00378 274 VQLTPGTDVCLglrmaasttrvpATAVADGGAWKEAKDdcevLYsLFPGEPDVTGDQL----SEYVREQLQAVPDI-VVY 348

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493833878 294 IEDGLQEEDWEGWQLMTKKLGHRVQLVGDDLFV-TNTKRLKKGIELGAANSILVKVNQIGTLSESFDAIEMAKQ 366
Cdd:PTZ00378 349 VEDTHCDEDTFGLQRLQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIVLNPCAIGTLSDVVEIVRAVGE 422
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
 26-368 5.48e-05

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 44.81  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878  26 VEVQLEGGAVGRAAVPSGastgkfeavelrdggrryhGLGVKKAVEHVNTILAEAIMfenALDQRHIDRLLREADGTENK 105
Cdd:COG4948   34 VRVETDDGITGWGEAVPG-------------------GTGAEAVAAALEEALAPLLI---GRDPLDIEALWQRLYRALPG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 106 ENMganAILGVSMAV----ARAaangLEMPLYRYLGGIGAHELPVpmmnilnGGVHADNTVDlqefmimpvgaESFSEGL 181
Cdd:COG4948   92 NPA---AKAAVDMALwdllGKA----LGVPVYQLLGGKVRDRVPV-------YATLGIDTPE-----------EMAEEAR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 182 QMCAEIYHTLKkiLKAGGyatavgdeggfaPNLKNTEEVLSYIVDAiklsgyeAGTQVKIAIDAasselyNeesGMYvfp 261
Cdd:COG4948  147 EAVARGFRALK--LKVGG------------PDPEEDVERVRAVREA-------VGPDARLRVDA------N---GAW--- 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493833878 262 gesqmsgiqverTAEEMVDyYLRLVDGFPIISIEDGLQEEDWEGWQLMTKKLghRVQLVGDDLfVTNTKRLKKGIELGAA 341
Cdd:COG4948  194 ------------TLEEAIR-LLRALEDLGLEWIEQPLPAEDLEGLAELRRAT--PVPIAADES-LTSRADFRRLIEAGAV 257

                        330       340
                 ....*....|....*....|....*..
gi 493833878 342 NSILVKVNQIGTLSESFDAIEMAKQAG 368
Cdd:COG4948  258 DIVNIKLSKVGGLTEALRIAALAEAHG 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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