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Conserved domains on  [gi|493862288|ref|WP_006809044|]
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MULTISPECIES: LuxR C-terminal-related transcriptional regulator [Enterobacter]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10677008)

helix-turn-helix (HTH) transcriptional regulator containing a LuxR family HTH DNA-binding domain; may act as a transcription activator/repressor, or have a dual role for different sites

Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 136-191 3.64e-09

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


:

Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 50.99  E-value: 3.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 493862288   136 GLSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLL 191
Cdd:smart00421   3 SLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
65-194 3.74e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


:

Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 54.38  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  65 ELLARQKGIVIGLVDDEQRFSALSSCYQDIVFIPRRASLDRISGLLFIAWYATQLPGYTWNKKTCFDCQHKGLSRQQMRI 144
Cdd:COG2771   56 AALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREV 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 493862288 145 MVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRRL 194
Cdd:COG2771  136 LRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRL 185
 
Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 136-191 3.64e-09

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 50.99  E-value: 3.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 493862288   136 GLSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLL 191
Cdd:smart00421   3 SLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
65-194 3.74e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 54.38  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  65 ELLARQKGIVIGLVDDEQRFSALSSCYQDIVFIPRRASLDRISGLLFIAWYATQLPGYTWNKKTCFDCQHKGLSRQQMRI 144
Cdd:COG2771   56 AALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREV 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 493862288 145 MVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRRL 194
Cdd:COG2771  136 LRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRL 185
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 137-194 7.16e-09

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 52.20  E-value: 7.16e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 493862288 137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRRL 194
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 137-193 8.12e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 50.23  E-value: 8.12e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 493862288 137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRR 193
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
137-190 1.34e-07

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 46.81  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 493862288  137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVL 190
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRM 56
PRK09483 PRK09483
response regulator; Provisional
 135-187 3.41e-04

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 40.47  E-value: 3.41e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 493862288 135 KGLSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYEL 187
Cdd:PRK09483 147 ASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVEL 199
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 16-184 6.77e-04

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 39.34  E-value: 6.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  16 GLQHFFEDFFKHNFHRSI-----TFHLGLTNENVSqADIIVLS----------LCQGETLTCFPellaRQKGIVIGLVDD 80
Cdd:PRK11475   5 GIESLFRKFPGNPYKLHTfssqsSFQDAMSRISFS-AVIFSLSamrserreglSCLTELAIKFP----RMRRLVIADDDI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  81 EQRF-SALS-SCYQDIvfIPRRASLDRISGLLFIAW----YATQLPGYTWnkktcFDCQHKGLS---RQQMRIMVNfyrG 151
Cdd:PRK11475  80 EARLiGSLSpSPLDGV--LSKASTLEILQQELFLSLngvrQATDRLNNQW-----YINQSRMLSpteREILRFMSR---G 149

                        170       180       190
                 ....*....|....*....|....*....|...
gi 493862288 152 LSVVQTANALKMSEKTVFTHKYMMMQKFNLRSD 184
Cdd:PRK11475 150 YSMPQIAEQLERNIKTIRAHKFNVMSKLGVSSD 182
 
Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 136-191 3.64e-09

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 50.99  E-value: 3.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 493862288   136 GLSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLL 191
Cdd:smart00421   3 SLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
65-194 3.74e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 54.38  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  65 ELLARQKGIVIGLVDDEQRFSALSSCYQDIVFIPRRASLDRISGLLFIAWYATQLPGYTWNKKTCFDCQHKGLSRQQMRI 144
Cdd:COG2771   56 AALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREV 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 493862288 145 MVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRRL 194
Cdd:COG2771  136 LRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRL 185
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 137-194 7.16e-09

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 52.20  E-value: 7.16e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 493862288 137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRRL 194
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 137-193 8.12e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 50.23  E-value: 8.12e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 493862288 137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRR 193
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
137-190 1.34e-07

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 46.81  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 493862288  137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVL 190
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRM 56
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 135-194 3.43e-05

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 40.71  E-value: 3.43e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288 135 KGLSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRRL 194
Cdd:COG5905   11 SLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRL 70
PRK09483 PRK09483
response regulator; Provisional
 135-187 3.41e-04

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 40.47  E-value: 3.41e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 493862288 135 KGLSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYEL 187
Cdd:PRK09483 147 ASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVEL 199
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 16-184 6.77e-04

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 39.34  E-value: 6.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  16 GLQHFFEDFFKHNFHRSI-----TFHLGLTNENVSqADIIVLS----------LCQGETLTCFPellaRQKGIVIGLVDD 80
Cdd:PRK11475   5 GIESLFRKFPGNPYKLHTfssqsSFQDAMSRISFS-AVIFSLSamrserreglSCLTELAIKFP----RMRRLVIADDDI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  81 EQRF-SALS-SCYQDIvfIPRRASLDRISGLLFIAW----YATQLPGYTWnkktcFDCQHKGLS---RQQMRIMVNfyrG 151
Cdd:PRK11475  80 EARLiGSLSpSPLDGV--LSKASTLEILQQELFLSLngvrQATDRLNNQW-----YINQSRMLSpteREILRFMSR---G 149

                        170       180       190
                 ....*....|....*....|....*....|...
gi 493862288 152 LSVVQTANALKMSEKTVFTHKYMMMQKFNLRSD 184
Cdd:PRK11475 150 YSMPQIAEQLERNIKTIRAHKFNVMSKLGVSSD 182
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
137-193 1.02e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 38.72  E-value: 1.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 493862288 137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLRR 193
Cdd:PRK09958 144 LSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQR 200
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
137-190 3.96e-03

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 37.14  E-value: 3.96e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493862288 137 LSRQQMRIMVNFYRGLSVVQTANALKMSEKTVFTHKYMMMQKFNLRSDYELIVL 190
Cdd:PRK10403 154 LTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATIL 207
PRK15201 PRK15201
fimbriae biosynthesis transcriptional regulator FimW;
1-192 8.54e-03

fimbriae biosynthesis transcriptional regulator FimW;


Pssm-ID: 185123  Cd Length: 198  Bit Score: 36.18  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288   1 MLNILIQETDLFFQAGLQHFFEDFfKHNFHRSITFhlgLTNENVSQADIIVLSLCQGE-TLTCF--PELLARQKGIVIGL 77
Cdd:PRK15201   1 MLSIAIKEQNSHFEHGLKIIMTRL-ANQWQQKIDF---LPPEEIDNADIAFLALDDDWfSAGCYqiPMHTQHQLRVIICN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493862288  78 VDDEQRFsALSSCYQDIVFIPRRASLDRISGLLFIAWYATQLPgYTWNKKTCFDCQHKGLSRQQMRIMVNFYRGLSVVQT 157
Cdd:PRK15201  77 KCDKEKL-MFRPCLYMLPHIYREDDVEEITRKMILILHKRALR-HSVPSGICHYCTTRHFSVTERHLLKLIASGYHLSET 154

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 493862288 158 ANALKMSEKTVFTHKYMMMQKFNLRSDYELIVLLR 192
Cdd:PRK15201 155 AALLSLSEEQTKSLRRSIMRKLHVKTEQQFLKYIR 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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