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Conserved domains on  [gi|493863700|ref|WP_006810434|]
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MULTISPECIES: phosphonate metabolism transcriptional regulator PhnF [Enterobacter]

Protein Classification

phosphonate metabolism transcriptional regulator PhnF( domain architecture ID 11484569)

phosphonate metabolism transcriptional regulator PhnF belongs to an operon involved in alkylphosphonate uptake and C-P lyase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 1-241 8.38e-171

phosphonate metabolism transcriptional regulator PhnF; Provisional


:

Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 470.03  E-value: 8.38e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   1 MHLSRHPTSYPTRWQEIAAKLEVELRTHYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPF 80
Cdd:PRK10079   1 MHLSRHPTSYPTRYQEIAAKLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  81 DYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQ 160
Cdd:PRK10079  81 DYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700 161 HFASGSLHDFLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVNATEYSVSLTRADMIEFTME 240
Cdd:PRK10079 161 RFDSGSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDGESSPAEYSVSLTRADMIEFTME 240


                 .
gi 493863700 241 H 241
Cdd:PRK10079 241 H 241
 
Name Accession Description Interval E-value
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 1-241 8.38e-171

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 470.03  E-value: 8.38e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   1 MHLSRHPTSYPTRWQEIAAKLEVELRTHYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPF 80
Cdd:PRK10079   1 MHLSRHPTSYPTRYQEIAAKLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  81 DYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQ 160
Cdd:PRK10079  81 DYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700 161 HFASGSLHDFLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVNATEYSVSLTRADMIEFTME 240
Cdd:PRK10079 161 RFDSGSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDGESSPAEYSVSLTRADMIEFTME 240


                 .
gi 493863700 241 H 241
Cdd:PRK10079 241 H 241
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 6-241 4.25e-115

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 329.05  E-value: 4.25e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700    6 HPTSYPTRWQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPL 84
Cdd:TIGR02325   2 ERTSGVALWRQIADKIEQEIAAgHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   85 NAQARFSQNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQHFA- 163
Cdd:TIGR02325  82 SARTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAa 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493863700  164 SGSLHDFLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHrDGDVNATEYSVSLTRADMIEFTMEH 241
Cdd:TIGR02325 162 SGSITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNH-DGEGRPVQYSVSRFRADRVEFTMEN 238
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-240 9.50e-59

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 185.84  E-value: 9.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  13 RWQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPLNAQARFS 91
Cdd:COG2188    6 LYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  92 QNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFaDLTLWPVL--QHFASGSLHD 169
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYL-PAALFPGLleEDLETGSLYE 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493863700 170 FLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVnATEYSVSLTRADMIEFTME 240
Cdd:COG2188  165 LLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGR-PVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-236 9.50e-30

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 108.07  E-value: 9.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   96 DQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYF-ADLTLWPVLQHFASGSLHDFLQDA 174
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLpAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493863700  175 TGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVnATEYSVSLTRADMIE 236
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGR-PVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-236 2.50e-24

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 94.28  E-value: 2.50e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700    96 DQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQHFASGSLHDFLQD-- 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEErl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493863700   174 -ATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDvNATEYSVSLTRADMIE 236
Cdd:smart00866  81 gLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDG-RPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-75 5.38e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 67.47  E-value: 5.38e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493863700  12 TRWQEIAAKLEVELRTH-YRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLV 75
Cdd:cd07377    1 PLYEQIADQLREAILSGeLKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 1-241 8.38e-171

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 470.03  E-value: 8.38e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   1 MHLSRHPTSYPTRWQEIAAKLEVELRTHYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPF 80
Cdd:PRK10079   1 MHLSRHPTSYPTRYQEIAAKLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  81 DYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQ 160
Cdd:PRK10079  81 DYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700 161 HFASGSLHDFLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVNATEYSVSLTRADMIEFTME 240
Cdd:PRK10079 161 RFDSGSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDGESSPAEYSVSLTRADMIEFTME 240


                 .
gi 493863700 241 H 241
Cdd:PRK10079 241 H 241
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 6-241 4.25e-115

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 329.05  E-value: 4.25e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700    6 HPTSYPTRWQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPL 84
Cdd:TIGR02325   2 ERTSGVALWRQIADKIEQEIAAgHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   85 NAQARFSQNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQHFA- 163
Cdd:TIGR02325  82 SARTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAa 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493863700  164 SGSLHDFLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHrDGDVNATEYSVSLTRADMIEFTMEH 241
Cdd:TIGR02325 162 SGSITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNH-DGEGRPVQYSVSRFRADRVEFTMEN 238
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-240 9.50e-59

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 185.84  E-value: 9.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  13 RWQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPLNAQARFS 91
Cdd:COG2188    6 LYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  92 QNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFaDLTLWPVL--QHFASGSLHD 169
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYL-PAALFPGLleEDLETGSLYE 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493863700 170 FLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVnATEYSVSLTRADMIEFTME 240
Cdd:COG2188  165 LLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGR-PVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-236 9.50e-30

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 108.07  E-value: 9.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700   96 DQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYF-ADLTLWPVLQHFASGSLHDFLQDA 174
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLpAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493863700  175 TGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDVnATEYSVSLTRADMIE 236
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGR-PVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-236 2.50e-24

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 94.28  E-value: 2.50e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700    96 DQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHYFADLTLWPVLQHFASGSLHDFLQD-- 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEErl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493863700   174 -ATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNHRDGDvNATEYSVSLTRADMIE 236
Cdd:smart00866  81 gLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDG-RPVEYSRSYYRGDRFR 143
PRK11402 PRK11402
transcriptional regulator PhoB;
29-240 5.48e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 87.97  E-value: 5.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  29 YRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPLNAQARFSQNLLDQGShPTSEKLLS 108
Cdd:PRK11402  27 YQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDFGVSQGK-ATKEKVIE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700 109 VLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVC-QIDHYfaDLTLWPVL-QHFASG-SLHDFLQDATGIALKRTQTR 185
Cdd:PRK11402 106 QERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFiDSSWI--PLSRYPDFdEIYVEGsSTYQLFQERFDTRVVSDKKT 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493863700 186 ISARRAQAKESKVLEIPNMAPLLCVRTLNHrDGDVNATEYSVSLTRADMIEFTME 240
Cdd:PRK11402 184 IDIFAATRPEAKWLKCELGEPLFRISKIAF-DQNDKPVHVSELFCRANRVTLTID 237
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-75 2.86e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.42  E-value: 2.86e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493863700   15 QEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLV 75
Cdd:pfam00392   3 EQVYARLREDILSgRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-75 1.24e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 71.45  E-value: 1.24e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700    17 IAAKLEVELRTH-YRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLV 75
Cdd:smart00345   1 VAERLREDIVSGeLRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK09764 PRK09764
GntR family transcriptional regulator;
13-239 9.25e-16

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 73.71  E-value: 9.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  13 RWQEIAAKLEVEL-RTHYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPLNAQARFS 91
Cdd:PRK09764   6 LYRQIADRIREQIaRGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  92 QNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVCQIDHY-----FADLTlWPVLQHfasgS 166
Cdd:PRK09764  86 EKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWmplalFPDLT-WQVMEN----S 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493863700 167 LHDFLQDATGIALKRTQTRISARRAQAKESKVLEIPNMAPLLCVRTLNH-RDGDVnaTEYSVSLTRADMIEFTM 239
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYlVDGRV--FEYSRNAFNTDDYKFTL 232
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-75 5.38e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 67.47  E-value: 5.38e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493863700  12 TRWQEIAAKLEVELRTH-YRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLV 75
Cdd:cd07377    1 PLYEQIADQLREAILSGeLKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
7-79 1.07e-10

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 59.56  E-value: 1.07e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493863700   7 PTSYPTRWQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRP 79
Cdd:COG2186    2 PIRRRSLAEQVAEQLRELILSgELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPS 75
PRK14999 PRK14999
histidine utilization repressor; Provisional
 10-211 1.73e-08

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 53.40  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  10 YPTRWQEIAAKLEvelRTHYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYPLNAQAR 89
Cdd:PRK14999  14 YETVKQDICKKIA---GGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493863700  90 FSQNLLDQGSHPTSEKLLSVLRPASRHVADALGIQEGDNVVHLRTLRRVNGVAVcQIDHYFADLTLWP--VLQHFASGSL 167
Cdd:PRK14999  91 IAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPV-QIEDRCVNADIAVdyLTQDYRQTTP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 493863700 168 HDFLQDATgiALKRTQTRISARRAQAKESKVLEIPNMAPLLCVR 211
Cdd:PRK14999 170 HAYLSRIA--PLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIR 211
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-72 1.27e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 51.75  E-value: 1.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493863700   1 MHLSRHPTSYPTRWQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVG 72
Cdd:COG1167    1 MLIRLDRDSSGPLYLQLADALREAILSgRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSG 73
PRK10225 PRK10225
Uxu operon transcriptional regulator;
14-76 2.77e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 50.02  E-value: 2.77e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493863700  14 WQEIAAKL-EVELRTHYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVL 76
Cdd:PRK10225  11 YQEVGAMIrDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVL 74
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 27-83 6.52e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 45.91  E-value: 6.52e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 493863700  27 THYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVLMRPFDYP 83
Cdd:PRK10421  18 KNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWS 74
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
30-84 8.33e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 45.78  E-value: 8.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 493863700  30 RCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLV---LMRPFDYPL 84
Cdd:PRK09464  29 RPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVqssLWQSFSDPL 86
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
32-75 1.30e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 43.24  E-value: 1.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 493863700  32 GDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLV 75
Cdd:COG1725   31 GDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFV 74
PRK11523 PRK11523
transcriptional regulator ExuR;
11-76 4.38e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 43.30  E-value: 4.38e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493863700  11 PTR-WQEIAAKLEVELRT-HYRCGDYLPAEQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVL 76
Cdd:PRK11523   6 PRRlYQQLAAELKERIEQgVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVV 73
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
38-81 5.60e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 36.82  E-value: 5.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 493863700  38 EQQLADRYEVNRHTLRRAIDQLVERGWVQRRQGVGVLVlmRPFD 81
Cdd:COG1802   37 EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV--APLS 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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