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Conserved domains on  [gi|493864743|ref|WP_006811453|]
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MULTISPECIES: cysteine synthase A [Enterobacter]

Protein Classification

cysteine synthase A( domain architecture ID 10795719)

cysteine synthase A (CysK/CysB/CysE) catalyzes the conversion of O-succinyl-L-serine/O-acetyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway

EC:  2.5.1.47
Gene Ontology:  GO:0019344|GO:0004124|GO:0030170

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 8-312 2.56e-173

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


:

Pssm-ID: 273465  Cd Length: 298  Bit Score: 482.25  E-value: 2.56e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    8 NSLTIGHTPLVRLNRI--GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARG 85
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIegCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   86 YKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYLLLQQFSNPANPEIHEKTTGPEIWEDT 165
Cdd:TIGR01139  81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYFMLQQFENPANPEIHRKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  166 DGQVDVFISGVGTGGTLTGVSRYIKGTKGkkDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNLDLKLID 245
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKP--NIKIVAVEPAESPVLSGG------KPGPHKIQGIGAGFIPKNLNRSVID 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493864743  246 KVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLSTALF 312
Cdd:TIGR01139 233 EVITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
 
Name Accession Description Interval E-value
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 8-312 2.56e-173

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 482.25  E-value: 2.56e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    8 NSLTIGHTPLVRLNRI--GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARG 85
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIegCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   86 YKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYLLLQQFSNPANPEIHEKTTGPEIWEDT 165
Cdd:TIGR01139  81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYFMLQQFENPANPEIHRKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  166 DGQVDVFISGVGTGGTLTGVSRYIKGTKGkkDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNLDLKLID 245
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKP--NIKIVAVEPAESPVLSGG------KPGPHKIQGIGAGFIPKNLNRSVID 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493864743  246 KVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLSTALF 312
Cdd:TIGR01139 233 EVITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
PRK10717 PRK10717
cysteine synthase A; Provisional
 2-323 9.43e-158

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 443.92  E-value: 9.43e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   2 SKIYEDNSLTIGHTPLVRLNRIGN---GRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALA 78
Cdd:PRK10717   1 MKIFEDVSDTIGNTPLIRLNRASEatgCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  79 YVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGA------KGMKGAIQKAEEIVASDPAKYLLLQQFSNPANPEI 152
Cdd:PRK10717  81 LVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAApyanpnNYVKGAGRLAEELVASEPNGAIWANQFDNPANREA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 153 HEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVSRYIKGTKGkkDLITVAVEPTDSPVIAQALAGEEIKPGPHKIQGIGA 232
Cdd:PRK10717 161 HYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNP--KVKIVLADPTGSALYSYYKTGELKAEGSSITEGIGQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 233 GFIPGNLDLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDEtFTNKNIVVILPSSGERYLSTALF 312
Cdd:PRK10717 239 GRITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLAREL-GPGHTIVTILCDSGERYQSKLFN 317

                        330
                 ....*....|.
gi 493864743 313 ADLFTEKELQQ 323
Cdd:PRK10717 318 PDFLREKGLPV 328
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 3-309 8.29e-150

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 422.53  E-value: 8.29e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   3 KIYEDNSLTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAY 79
Cdd:COG0031    2 RIYDSILELIGNTPLVRLNRLSPGpgaEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  80 VAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHEKTTGP 159
Cdd:COG0031   82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETP-GAFWPNQFENPANPEAHYETTGP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 160 EIWEDTDGQVDVFISgvgtggtltgvSRYIKgtKGKKDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNL 239
Cdd:COG0031  161 EIWEQTDGKVDAFVAgvgtggtitgvGRYLK--ERNPDIKIVAVEPEGSPLLSGG------EPGPHKIEGIGAGFVPKIL 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 240 DLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLST 309
Cdd:COG0031  233 DPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLG-PGKTIVTILPDSGERYLST 301
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 13-308 6.14e-130

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 371.85  E-value: 6.14e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  13 GHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKLT 89
Cdd:cd01561    1 GNTPLVRLNRLSPGtgaEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  90 LTMPETMSIERRKLLKALGANLVLTEGAK--GMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHEKTTGPEIWEDTDG 167
Cdd:cd01561   81 IVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETP-NAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 168 QVDVFISGVGTGGTLTGVSRYIKgtKGKKDLITVAVEPTDSPVIaqalagEEIKPGPHKIQGIGAGFIPGNLDLKLIDKV 247
Cdd:cd01561  160 KVDAFVAGVGTGGTITGVARYLK--EKNPNVRIVGVDPVGSVLF------SGGPPGPHKIEGIGAGFIPENLDRSLIDEV 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493864743 248 VAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLS 308
Cdd:cd01561  232 VRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 9-275 9.78e-63

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 201.00  E-value: 9.78e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    9 SLTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRgvlKPGVELVEPTSGNTGIALAYVAAARG 85
Cdd:pfam00291   2 SLGIGPTPLVRLPRLSkelGVDVYLKLESLNPTGSFKDRGALNLLLRLKEG---EGGKTVVEASSGNHGRALAAAAARLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   86 YKLTLTMPETMSIERRKLLKALGANLVLTEGakGMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHeKTTGPEIWEDT 165
Cdd:pfam00291  79 LKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGP-GAYYINQYDNPLNIEGY-GTIGLEILEQL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  166 DGQVDVFISGVGTGGTLTGVSRYIKGTKGKKDLItvAVEPTDSPVIAQALAG---EEIKPGPHKIQGIGAGFIPGNLDLK 242
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVI--GVEPEGAPALARSLAAgrpVPVPVADTIADGLGVGDEPGALALD 232

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 493864743  243 LIDK----VVAITNEEAISTARRLMDEEGILAGISSG 275
Cdd:pfam00291 233 LLDEyvgeVVTVSDEEALEAMRLLARREGIVVEPSSA 269
 
Name Accession Description Interval E-value
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 8-312 2.56e-173

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 482.25  E-value: 2.56e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    8 NSLTIGHTPLVRLNRI--GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARG 85
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIegCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   86 YKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYLLLQQFSNPANPEIHEKTTGPEIWEDT 165
Cdd:TIGR01139  81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYFMLQQFENPANPEIHRKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  166 DGQVDVFISGVGTGGTLTGVSRYIKGTKGkkDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNLDLKLID 245
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKP--NIKIVAVEPAESPVLSGG------KPGPHKIQGIGAGFIPKNLNRSVID 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493864743  246 KVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLSTALF 312
Cdd:TIGR01139 233 EVITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 8-312 9.87e-159

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 445.19  E-value: 9.87e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    8 NSLTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAAR 84
Cdd:TIGR01136   1 IEELIGNTPLVRLNRLApgcDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGDTIIEATSGNTGIALAMVAAAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   85 GYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHEKTTGPEIWED 164
Cdd:TIGR01136  81 GYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETN-KYVMLDQFENPANPEAHYKTTGPEIWRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  165 TDGQVDVFISGVGTGGTLTGVSRYIKGTKGkkDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNLDLKLI 244
Cdd:TIGR01136 160 TDGRIDHFVAGVGTGGTITGVGRYLKEQNP--NIQIVAVEPAESPVLSGG------EPGPHKIQGIGAGFIPKILDLSLI 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493864743  245 DKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETFTNKNIVVILPSSGERYLSTALF 312
Cdd:TIGR01136 232 DEVITVSDEDAIETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
PRK10717 PRK10717
cysteine synthase A; Provisional
 2-323 9.43e-158

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 443.92  E-value: 9.43e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   2 SKIYEDNSLTIGHTPLVRLNRIGN---GRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALA 78
Cdd:PRK10717   1 MKIFEDVSDTIGNTPLIRLNRASEatgCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  79 YVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGA------KGMKGAIQKAEEIVASDPAKYLLLQQFSNPANPEI 152
Cdd:PRK10717  81 LVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAApyanpnNYVKGAGRLAEELVASEPNGAIWANQFDNPANREA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 153 HEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVSRYIKGTKGkkDLITVAVEPTDSPVIAQALAGEEIKPGPHKIQGIGA 232
Cdd:PRK10717 161 HYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNP--KVKIVLADPTGSALYSYYKTGELKAEGSSITEGIGQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 233 GFIPGNLDLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDEtFTNKNIVVILPSSGERYLSTALF 312
Cdd:PRK10717 239 GRITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLAREL-GPGHTIVTILCDSGERYQSKLFN 317

                        330
                 ....*....|.
gi 493864743 313 ADLFTEKELQQ 323
Cdd:PRK10717 318 PDFLREKGLPV 328
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 3-309 8.29e-150

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 422.53  E-value: 8.29e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   3 KIYEDNSLTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAY 79
Cdd:COG0031    2 RIYDSILELIGNTPLVRLNRLSPGpgaEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  80 VAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHEKTTGP 159
Cdd:COG0031   82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETP-GAFWPNQFENPANPEAHYETTGP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 160 EIWEDTDGQVDVFISgvgtggtltgvSRYIKgtKGKKDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNL 239
Cdd:COG0031  161 EIWEQTDGKVDAFVAgvgtggtitgvGRYLK--ERNPDIKIVAVEPEGSPLLSGG------EPGPHKIEGIGAGFVPKIL 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 240 DLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLST 309
Cdd:COG0031  233 DPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLG-PGKTIVTILPDSGERYLST 301
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 13-308 6.14e-130

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 371.85  E-value: 6.14e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  13 GHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKLT 89
Cdd:cd01561    1 GNTPLVRLNRLSPGtgaEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  90 LTMPETMSIERRKLLKALGANLVLTEGAK--GMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHEKTTGPEIWEDTDG 167
Cdd:cd01561   81 IVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETP-NAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 168 QVDVFISGVGTGGTLTGVSRYIKgtKGKKDLITVAVEPTDSPVIaqalagEEIKPGPHKIQGIGAGFIPGNLDLKLIDKV 247
Cdd:cd01561  160 KVDAFVAGVGTGGTITGVARYLK--EKNPNVRIVGVDPVGSVLF------SGGPPGPHKIEGIGAGFIPENLDRSLIDEV 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493864743 248 VAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSSGERYLS 308
Cdd:cd01561  232 VRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PLN02565 PLN02565
cysteine synthase
 2-320 2.72e-112

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 328.42  E-value: 2.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   2 SKIYEDNSLTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVE-LVEPTSGNTGIAL 77
Cdd:PLN02565   3 SSIAKDVTELIGKTPLVYLNNVVDGcvaRIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESvLIEPTSGNTGIGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  78 AYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYLLlQQFSNPANPEIHEKTT 157
Cdd:PLN02565  83 AFMAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYIL-QQFENPANPKIHYETT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 158 GPEIWEDTDGQVDVFISGVGTGGTLTGVSRYIKgtKGKKDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPG 237
Cdd:PLN02565 162 GPEIWKGTGGKVDAFVSGIGTGGTITGAGKYLK--EQNPDIKLYGVEPVESAVLSGG------KPGPHKIQGIGAGFIPG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 238 NLDLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETFTNKNIVVILPSSGERYLSTALFADLFT 317
Cdd:PLN02565 234 VLDVDLLDEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKK 313


                 ...
gi 493864743 318 EKE 320
Cdd:PLN02565 314 EAE 316
PLN03013 PLN03013
cysteine synthase
 4-323 4.22e-102

cysteine synthase


Pssm-ID: 178587 [Multi-domain]  Cd Length: 429  Bit Score: 306.32  E-value: 4.22e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   4 IYEDNSLTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVE-LVEPTSGNTGIALAY 79
Cdd:PLN03013 113 IADNVSQLIGKTPMVYLNSIAKGcvaNIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSvLVEPTSGNTGIGLAF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  80 VAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYlLLQQFSNPANPEIHEKTTGP 159
Cdd:PLN03013 193 IAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAY-MLQQFDNPANPKIHYETTGP 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 160 EIWEDTDGQVDVFISGVGTGGTLTGVSRYIKGTKGKKDLItvAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNL 239
Cdd:PLN03013 272 EIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVI--GVEPTESDILSGG------KPGPHKIQGIGAGFIPKNL 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 240 DLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETFTNKNIVVILPSSGeRYLSTALFADLFTEK 319
Cdd:PLN03013 344 DQKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKR 422


                 ....
gi 493864743 320 ELQQ 323
Cdd:PLN03013 423 WRKC 426
PLN00011 PLN00011
cysteine synthase
 4-320 7.47e-101

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 299.23  E-value: 7.47e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   4 IYEDNSLTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVE-LVEPTSGNTGIALAY 79
Cdd:PLN00011   7 IKNDVTELIGNTPMVYLNNIVDGcvaRIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKStLIEATAGNTGIGLAC 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  80 VAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYLLlQQFSNPANPEIHEKTTGP 159
Cdd:PLN00011  87 IGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIP-QQFENPANPEIHYRTTGP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 160 EIWEDTDGQVDVFISGVGTGGTLTGVSRYIKgtKGKKDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPGNL 239
Cdd:PLN00011 166 EIWRDSAGKVDILVAGVGTGGTATGVGKFLK--EKNKDIKVCVVEPVESAVLSGG------QPGPHLIQGIGSGIIPFNL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 240 DLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETFTNKNIVVILPSSGERYLSTALFADLFTEK 319
Cdd:PLN00011 238 DLTIVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEA 317


                 .
gi 493864743 320 E 320
Cdd:PLN00011 318 E 318
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 2-323 1.14e-92

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 280.31  E-value: 1.14e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   2 SKIYEDNSLTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPG-VELVEPTSGNTGIAL 77
Cdd:PLN02556  47 TKIKTDASQLIGKTPLVYLNKVTEGcgaYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGkTTLIEPTSGNMGISL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  78 AYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPAKYLLlQQFSNPANPEIHEKTT 157
Cdd:PLN02556 127 AFMAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFML-QQFSNPANTQVHFETT 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 158 GPEIWEDTDGQVDVFISGVGTGGTLTGVSRYIKGTKgkKDLITVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIPG 237
Cdd:PLN02556 206 GPEIWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSKN--PNVKIYGVEPAESNVLNGG------KPGPHHITGNGVGFKPD 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 238 NLDLKLIDKVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETFTNKNIVVILPSSGERYLSTALFADLFT 317
Cdd:PLN02556 278 ILDMDVMEKVLEVSSEDAVNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRK 357


                 ....*.
gi 493864743 318 EKELQQ 323
Cdd:PLN02556 358 EAENMQ 363
cysM PRK11761
cysteine synthase CysM;
11-312 9.57e-89

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 267.51  E-value: 9.57e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  11 TIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYK 87
Cdd:PRK11761   9 TIGNTPLVKLQRLPpdrGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPGDTLIEATSGNTGIALAMIAAIKGYR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  88 LTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASdpAKYLLLQQFSNPANPEIHEKTTGPEIWEDTDG 167
Cdd:PRK11761  89 MKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAE--GEGKVLDQFANPDNPLAHYETTGPEIWRQTEG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 168 QVDVFISGVGTGGTLTGVSRYIKgtKGKKDLITVAVEPTDspviaqalaGEEIkPGphkIQGIGAGFIPGNLDLKLIDKV 247
Cdd:PRK11761 167 RITHFVSSMGTTGTIMGVSRYLK--EQNPAVQIVGLQPEE---------GSSI-PG---IRRWPEEYLPKIFDASRVDRV 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493864743 248 VAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEdetfTNKN--IVVILPSSGERYLSTALF 312
Cdd:PRK11761 232 LDVSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIAR----ENPNavIVAIICDRGDRYLSTGVF 294
cysta_beta TIGR01137
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ...
 12-308 3.28e-74

cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273464 [Multi-domain]  Cd Length: 455  Bit Score: 235.46  E-value: 3.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   12 IGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKL 88
Cdd:TIGR01137   9 IGNTPLVRLNKVSKGlkcELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPGDTIIEPTSGNTGIGLALVAAIKGYKC 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   89 TLTMPETMSIERRKLLKALGANLVLTEGAKGM---KGAIQKAEEIVASDPAKYlLLQQFSNPANPEIHEKTTGPEIWEDT 165
Cdd:TIGR01137  89 IIVLPEKMSSEKVDVLRALGAEIVRTPTAAAFdspESHIGVAKRLVREIPGAH-ILDQYRNPSNPLAHYDTTGPEILEQC 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  166 DGQVDVFISGVGTGGTLTGVSRYIKGTKGKkdLITVAVEPTDSpVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLID 245
Cdd:TIGR01137 168 EGKLDMFVAGVGTGGTITGIARYLKESCPG--CRIVGADPEGS-ILAQPEELNQTGRTPYKVEGIGYDFIPTVLDRKVVD 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493864743  246 KVVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETFTNKNIVVILPSSGERYLS 308
Cdd:TIGR01137 245 EWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDELQEGQRCVVLLPDSIRNYMT 307
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 9-275 9.78e-63

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 201.00  E-value: 9.78e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    9 SLTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRgvlKPGVELVEPTSGNTGIALAYVAAARG 85
Cdd:pfam00291   2 SLGIGPTPLVRLPRLSkelGVDVYLKLESLNPTGSFKDRGALNLLLRLKEG---EGGKTVVEASSGNHGRALAAAAARLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   86 YKLTLTMPETMSIERRKLLKALGANLVLTEGakGMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHeKTTGPEIWEDT 165
Cdd:pfam00291  79 LKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGP-GAYYINQYDNPLNIEGY-GTIGLEILEQL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  166 DGQVDVFISGVGTGGTLTGVSRYIKGTKGKKDLItvAVEPTDSPVIAQALAG---EEIKPGPHKIQGIGAGFIPGNLDLK 242
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVI--GVEPEGAPALARSLAAgrpVPVPVADTIADGLGVGDEPGALALD 232

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 493864743  243 LIDK----VVAITNEEAISTARRLMDEEGILAGISSG 275
Cdd:pfam00291 233 LLDEyvgeVVTVSDEEALEAMRLLARREGIVVEPSSA 269
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 15-302 4.14e-60

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 192.34  E-value: 4.14e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  15 TPLVRLNRI---GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVeLVEPTSGNTGIALAYVAAARGYKLTLT 91
Cdd:cd00640    1 TPLVRLKRLsklGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKLPKGV-IIESTGGNTGIALAAAAARLGLKCTIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  92 MPETMSIERRKLLKALGANLVLTEGakGMKGAIQKAEEIVASDPaKYLLLQQFSNPANPEIHeKTTGPEIWEDTDGQ-VD 170
Cdd:cd00640   80 MPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDP-GAYYVNQFDNPANIAGQ-GTIGLEILEQLGGQkPD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 171 VFISGVgtggtltgvsryikGTKGkkdLITvaveptdspviaqalageeikpgphkiqGIGAGFIPGNLDLKLI---DKV 247
Cdd:cd00640  156 AVVVPV--------------GGGG---NIA----------------------------GIARALKELLPNVKVIgvePEV 190

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493864743 248 VAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETfTNKNIVVILPSS 302
Cdd:cd00640  191 VTVSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKLG-KGKTVVVILTGG 244
PLN02356 PLN02356
phosphateglycerate kinase
 1-308 4.37e-27

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 110.08  E-value: 4.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   1 MSKIYEDNSL--TIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGI 75
Cdd:PLN02356  38 LSKKKPRNGLidAIGNTPLIRINSLSEAtgcEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPGGVVTEGSAGSTAI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  76 ALAYVAAARGYKLTLTMPETMSIERRKLLKALGAN--------------------------------LVLTEGAKG---- 119
Cdd:PLN02356 118 SLATVAPAYGCKCHVVIPDDVAIEKSQILEALGATvervrpvsithkdhyvniarrraleanelaskRRKGSETDGihle 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 120 -MKGAIQKAEE---IVASDPAKYLLLQQFSNPANPEIHEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVSRYIKgtKGK 195
Cdd:PLN02356 198 kTNGCISEEEKensLFSSSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQ--EKN 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 196 KDLITVAVEPTDSPVIAQALAG-----EEIK------PGPHKIQGIGAGFIPGNLDLKLIDKVVAITNEEAISTARRLMD 264
Cdd:PLN02356 276 PNIKCFLIDPPGSGLFNKVTRGvmytrEEAEgrrlknPFDTITEGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLK 355

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 493864743 265 EEGILAGISSGAAVAAALKLLEdETFTNKNIVVILPSSGERYLS 308
Cdd:PLN02356 356 NDGLFVGSSSAMNCVGAVRVAQ-SLGPGHTIVTILCDSGMRHLS 398
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 14-303 1.48e-13

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 69.82  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  14 HTPLVR---LNRIGNGRILAKVESRNPSFSVKCRiGA-NMIW----DAEKRGVlkpgvelVEPTSGNTGIALAYVAAARG 85
Cdd:cd01562   17 RTPLLTsptLSELLGAEVYLKCENLQKTGSFKIR-GAyNKLLslseEERAKGV-------VAASAGNHAQGVAYAAKLLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  86 YKLTLTMPETMSIERRKLLKALGANLVLTEgaKGMKGAIQKAEEIVASDPAKYLllqqfsNPANpeiHEK------TTGP 159
Cdd:cd01562   89 IPATIVMPETAPAAKVDATRAYGAEVVLYG--EDFDEAEAKARELAEEEGLTFI------HPFD---DPDviagqgTIGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 160 EIWEDTDGQVDVF--------ISgvgtggtltGVSRYIKGTKGKkdlITV-AVEPTDSPVIAQAL-AGEEIK-PGPHKIQ 228
Cdd:cd01562  158 EILEQVPDLDAVFvpvgggglIA---------GIATAVKALSPN---TKViGVEPEGAPAMAQSLaAGKPVTlPEVDTIA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 229 GIGAGFIPGNLDL----KLIDKVVAITNEEAISTARRLMDEEGI---------LAGISSGAavaaalklledETFTNKNI 295
Cdd:cd01562  226 DGLAVKRPGELTFeiirKLVDDVVTVSEDEIAAAMLLLFEREKLvaepagalaLAALLSGK-----------LDLKGKKV 294


                 ....*...
gi 493864743 296 VVILpsSG 303
Cdd:cd01562  295 VVVL--SG 300
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 14-303 2.86e-13

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 69.29  E-value: 2.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  14 HTPLVR---LNRIGNGRILAKVESRNPSFSVKCRIGANMIW----DAEKRGVlkpgvelVEPTSGNTGIALAYVAAARGY 86
Cdd:COG1171   24 RTPLLRsptLSERLGAEVYLKLENLQPTGSFKLRGAYNALAslseEERARGV-------VAASAGNHAQGVAYAARLLGI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  87 KLTLTMPETMSIERRKLLKALGANLVLTEGAkgMKGAIQKAEEIVASDpaKYLLLQQFSNP------AnpeihekTTGPE 160
Cdd:COG1171   97 PATIVMPETAPAVKVAATRAYGAEVVLHGDT--YDDAEAAAAELAEEE--GATFVHPFDDPdviagqG-------TIALE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 161 IWEDTdGQVDV---------FISgvgtggtltGVSRYIKGTkgKKDLITVAVEPTDSPVIAQALAGEEIK--PGPHKI-Q 228
Cdd:COG1171  166 ILEQL-PDLDAvfvpvggggLIA---------GVAAALKAL--SPDIRVIGVEPEGAAAMYRSLAAGEPVtlPGVDTIaD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 229 GIGAGfIPGNLDLKLI----DKVVAITNEEAISTARRLMDEEGI---------LAGISSGAavaaalklledETFTNKNI 295
Cdd:COG1171  234 GLAVG-RPGELTFEILrdlvDDIVTVSEDEIAAAMRLLLERTKIvvepagaaaLAALLAGK-----------ERLKGKRV 301


                 ....*...
gi 493864743 296 VVILpsSG 303
Cdd:COG1171  302 VVVL--SG 307
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 6-299 1.05e-11

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 65.22  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   6 EDNSLTIGH--TPLVRLNRIGN---GRILAKVESRNPSFSVKCR---IGANMiwdAEKRGVlkpgVELVEPTSGNTGIAL 77
Cdd:COG0498   56 EEKAVSLGEggTPLVKAPRLADelgKNLYVKEEGHNPTGSFKDRamqVAVSL---ALERGA----KTIVCASSGNGSAAL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  78 AYVAAARGYKLTLTMPET-MSIERRKLLKALGANLVLTEGAKGmkGAIQKAEEIvASDPAKYLLlqqfsNPANPEIHE-- 154
Cdd:COG0498  129 AAYAARAGIEVFVFVPEGkVSPGQLAQMLTYGAHVIAVDGNFD--DAQRLVKEL-AADEGLYAV-----NSINPARLEgq 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 155 KTTGPEIWEDTDGQVDVFIsgvgtggtltgvsrY--------IKGTKGKKDLIT----------VAVEPTDSPVIAQALA 216
Cdd:COG0498  201 KTYAFEIAEQLGRVPDWVV--------------VptgnggniLAGYKAFKELKElglidrlprlIAVQATGCNPILTAFE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 217 GEEIKPGPHKIQ------GIGagfIPGNLD--LKLIDK----VVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKL 284
Cdd:COG0498  267 TGRDEYEPERPEtiapsmDIG---NPSNGEraLFALREsggtAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLRKL 343

                        330
                 ....*....|....*
gi 493864743 285 LEDETFTNKNIVVIL 299
Cdd:COG0498  344 REEGEIDPDEPVVVL 358
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 9-303 4.38e-10

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 59.91  E-value: 4.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   9 SLTIGHTPLVRLNRI----GNGRILAKVESRNPSFSVKCRiGANM-IWDAEKRGVlkpgVELVEPTSGNTGIALAYVAAA 83
Cdd:cd01563   17 SLGEGNTPLVRAPRLgerlGGKNLYVKDEGLNPTGSFKDR-GMTVaVSKAKELGV----KAVACASTGNTSASLAAYAAR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  84 RGYKLTLTMPETMSIErrKLLKAL--GANLVLTEGakGMKGAIQKAEEIVASDPAkYLllqqfSNPANPEIHE--KTTGP 159
Cdd:cd01563   92 AGIKCVVFLPAGKALG--KLAQALayGATVLAVEG--NFDDALRLVRELAEENWI-YL-----SNSLNPYRLEgqKTIAF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 160 EIWEDTDGQV-DVFIsgvGTGGTLTGVSRYIKGTK--GKKDLIT-----VAVEPTDSPVIAQAL--AGEEIKPG--PHKI 227
Cdd:cd01563  162 EIAEQLGWEVpDYVV---VPVGNGGNITAIWKGFKelKELGLIDrlprmVGVQAEGAAPIVRAFkeGKDDIEPVenPETI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 228 -QGIGAGFiPGNLD--LKLIDK----VVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETF-TNKNIVVIL 299
Cdd:cd01563  239 aTAIRIGN-PASGPkaLRAVREsggtAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEGIIdKGERVVVVL 317


                 ....
gi 493864743 300 PSSG 303
Cdd:cd01563  318 TGHG 321
PRK08197 PRK08197
threonine synthase; Validated
 9-138 3.11e-09

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 57.70  E-value: 3.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   9 SLTIGHTPLVRLNR----IGNGRILAKVESRNPSFSVKCRiGANM-IWDAEKRGVlkpgVELVEPTSGNTGIALAYVAAA 83
Cdd:PRK08197  74 SLGEGMTPLLPLPRlgkaLGIGRLWVKDEGLNPTGSFKAR-GLAVgVSRAKELGV----KHLAMPTNGNAGAAWAAYAAR 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493864743  84 RGYKLTLTMPETMSIERRKLLKALGANLVLTEgakgmkGAIQKAEEIVASDPAKY 138
Cdd:PRK08197 149 AGIRATIFMPADAPEITRLECALAGAELYLVD------GLISDAGKIVAEAVAEY 197
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
 14-136 8.36e-08

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 52.69  E-value: 8.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  14 HTPLVR---LNRIGNGRILAKVESRNPSFSVKCR-IGaNMIWDAEKRGVLKPgVELVEPTSGNTGIALAYVAAARGYKLT 89
Cdd:cd06448    1 KTPLIEstaLSKTAGCNVFLKLENLQPSGSFKIRgIG-HLCQKSAKQGLNEC-VHVVCSSGGNAGLAAAYAARKLGVPCT 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 493864743  90 LTMPET---MSIERrklLKALGANLVLtEGAKGMKGAIQKAEEIVASDPA 136
Cdd:cd06448   79 IVVPEStkpRVVEK---LRDEGATVVV-HGKVWWEADNYLREELAENDPG 124
PRK06608 PRK06608
serine/threonine dehydratase;
12-114 1.98e-07

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 51.70  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  12 IGHTPLVR---LNRIGNGRILAKVESRNPSFSVKCRIGAN-MIWDAEKRgvlKPGVELVEPTSGNTGIALAYVAAARGYK 87
Cdd:PRK06608  21 LHLTPIVHsesLNEMLGHEIFFKVESLQKTGAFKVRGVLNhLLELKEQG---KLPDKIVAYSTGNHGQAVAYASKLFGIK 97

                         90       100
                 ....*....|....*....|....*..
gi 493864743  88 LTLTMPETMSIERRKLLKALGANLVLT 114
Cdd:PRK06608  98 TRIYLPLNTSKVKQQAALYYGGEVILT 124
PRK06450 PRK06450
threonine synthase; Validated
 9-129 3.28e-07

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 51.27  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   9 SLTIGHTPLVRlnrigNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkpgVELVEPTSGNTGIALAYVAAARGYKL 88
Cdd:PRK06450  53 SLGEGRTPLIK-----KGNIWFKLDFLNPTGSYKDRGSVTLISYLAEKGI----KQISEDSSGNAGASIAAYGAAAGIEV 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 493864743  89 TLTMPETMSIERRKLLKALGANLVLTEGAkgmKGAIQKAEE 129
Cdd:PRK06450 124 KIFVPETASGGKLKQIESYGAEVVRVRGS---REDVAKAAE 161
PRK06381 PRK06381
threonine synthase; Validated
 1-132 4.98e-07

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 50.47  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   1 MSKIYEDNSLTIGHTPLVRLNRIGN----GRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkPGVELvePTSGNTGIA 76
Cdd:PRK06381   2 EEELSSSEEKPPGGTPLLRARKLEEelglRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY--SGITV--GTCGNYGAS 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493864743  77 LAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGakgmkgaiqKAEEIVA 132
Cdd:PRK06381  78 IAYFARLYGLKAVIFIPRSYSNSRVKEMEKYGAEIIYVDG---------KYEEAVE 124
PRK05638 PRK05638
threonine synthase; Validated
 9-303 6.30e-07

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 50.58  E-value: 6.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   9 SLTIGHTPLVRlNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKpgveLVEPTSGNTGIALAYVAAARG 85
Cdd:PRK05638  61 SLGEGGTPLIR-ARISeklGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAANG----FIVASDGNAAASVAAYSARAG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  86 YKLTLTMPETMSIERRKLLKALGANLVLTEgaKGMKGAIQKAEEIvasdpAKYLLLQQFSNPANPEIHE--KTTGPEIWE 163
Cdd:PRK05638 136 KEAFVVVPRKVDKGKLIQMIAFGAKIIRYG--ESVDEAIEYAEEL-----ARLNGLYNVTPEYNIIGLEgqKTIAFELWE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 164 DTdGQVDVFISGVGTGGTLtgvSRYikgtKGKKDLIT----------VAVEPTDSPVIAQALAGEEIKPGPHKIQGIGA- 232
Cdd:PRK05638 209 EI-NPTHVIVPTGSGSYLY---SIY----KGFKELLEigvieeipklIAVQTERCNPIASEILGNKTKCNETKALGLYVk 280

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493864743 233 GFIPGNLDLKLIDK---VVAITNEEAISTARRLMDEEGILAGISSGAAVAAALKLLEDETF-TNKNIVVILPSSG 303
Cdd:PRK05638 281 NPVMKEYVSEAIKEsggTAVVVNEEEIMAGEKLLAKEGIFAELSSAVVMPALLKLGEEGYIeKGDKVVLVVTGSG 355
PRK08246 PRK08246
serine/threonine dehydratase;
12-129 1.42e-06

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 49.18  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  12 IGHTPLVRLNRIGNGR--ILAKVESRNPSFSVKCRiGA-NMIWDAEKrgvlkPGVELVEPTSGNTGIALAYVAAARGYKL 88
Cdd:PRK08246  21 IRRTPVLEADGAGFGPapVWLKLEHLQHTGSFKAR-GAfNRLLAAPV-----PAAGVVAASGGNAGLAVAYAAAALGVPA 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 493864743  89 TLTMPETMSIERRKLLKALGANLVLTEG--AKGMKGAIQKAEE 129
Cdd:PRK08246  95 TVFVPETAPPAKVARLRALGAEVVVVGAeyADALEAAQAFAAE 137
PRK06815 PRK06815
threonine/serine dehydratase;
15-299 3.16e-06

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 48.15  E-value: 3.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  15 TPL---VRLNRIGNGRILAKVESRNPSFSVKCRIGANMI--WDAEKRgvlKPGVelVEPTSGNTGIALAYVAAARGYKLT 89
Cdd:PRK06815  21 TPLehsPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLrlLNEAQR---QQGV--ITASSGNHGQGVALAAKLAGIPVT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  90 LTMPETMSIERRKLLKALGANLVLTeGAKGMKGaiqkaeEIVASDPAKylllQQ---FSNPAN-PEI--HEKTTGPEIWE 163
Cdd:PRK06815  96 VYAPEQASAIKLDAIRALGAEVRLY-GGDALNA------ELAARRAAE----QQgkvYISPYNdPQViaGQGTIGMELVE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743 164 DTDGQVDVFISGVGTGGTLTGVSrYIKGTKGKKDLItvAVEPTDSPVIAQAL-AGEEIKPG--PHKIQGIGAGFIPGNLD 240
Cdd:PRK06815 165 QQPDLDAVFVAVGGGGLISGIAT-YLKTLSPKTEII--GCWPANSPSLYTSLeAGEIVEVAeqPTLSDGTAGGVEPGAIT 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493864743 241 L----KLIDKVVAITnEEAISTARRLMDE------EGIlAGISsgaavaAALKLLEDETFTNKNIVVIL 299
Cdd:PRK06815 242 FplcqQLIDQKVLVS-EEEIKEAMRLIAEtdrwliEGA-AGVA------LAAALKLAPRYQGKKVAVVL 302
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
 9-169 1.38e-04

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 43.14  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743    9 SLTIGHTPLVRLNR----IGNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkpgVELVEPTSGNTGIALAYVAAAR 84
Cdd:TIGR00260  17 DLGEGVTPLFRAPAlaanVGIKNLYVKELGHNPTLSFKDRGMAVALTKALELGN----DTVLCASTGNTGAAAAAYAGKA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   85 GYKLTLTMPETmSIERRKLLKALGANlVLTEGAKGMKGAIQKAEEIVASDPAKYLLLQQFSNPANPEiHEKTTGPEIWED 164
Cdd:TIGR00260  93 GLKVVVLYPAG-KISLGKLAQALGYN-AEVVAIDGNFDDAQRLVKQLFEDKPALGLNSANSIPYRLE-GQKTYAFEAVEQ 169


                  ....*
gi 493864743  165 TDGQV 169
Cdd:TIGR00260 170 LGWEA 174
PRK12483 PRK12483
threonine dehydratase; Reviewed
 22-220 2.00e-04

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 42.86  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  22 RIGNgRILAKVESRNPSFSVKCRIG----ANMIWDAEKRGVlkpgvelVEPTSGNTGIALAYVAAARGYKLTLTMPETMS 97
Cdd:PRK12483  49 RLGN-QVLLKREDLQPVFSFKIRGAynkmARLPAEQLARGV-------ITASAGNHAQGVALAAARLGVKAVIVMPRTTP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  98 IERRKLLKALGANLVLTegAKGMKGAIQKAEEIVASDPAKYllLQQFSNPaNPEIHEKTTGPEIWEDTDGQVDVFISGVG 177
Cdd:PRK12483 121 QLKVDGVRAHGGEVVLH--GESFPDALAHALKLAEEEGLTF--VPPFDDP-DVIAGQGTVAMEILRQHPGPLDAIFVPVG 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 493864743 178 TGGTLTGVSRYIKGTkgKKDLITVAVEPTDSPVIAQAL-AGEEI 220
Cdd:PRK12483 196 GGGLIAGIAAYVKYV--RPEIKVIGVEPDDSNCLQAALaAGERV 237
PRK06110 PRK06110
threonine dehydratase;
31-112 1.06e-03

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 40.36  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  31 KVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVelVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGAN 110
Cdd:PRK06110  41 KHENHTPTGAFKVRGGLVYFDRLARRGPRVRGV--ISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAE 118


                 ..
gi 493864743 111 LV 112
Cdd:PRK06110 119 LI 120
PRK08329 PRK08329
threonine synthase; Validated
 9-121 1.94e-03

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 39.42  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743   9 SLTIGHTPLVRLNRigngRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkpgVELVEPTSGNTGIALAYVAAARGYKL 88
Cdd:PRK08329  59 HLTPPITPTVKRSI----KVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGI----NEVVIDSSGNAALSLALYSLSEGIKV 130

                         90       100       110
                 ....*....|....*....|....*....|...
gi 493864743  89 TLTMPETMSIERRKLLKALGANLVLTEGAKgMK 121
Cdd:PRK08329 131 HVFVSYNASKEKISLLSRLGAELHFVEGDR-ME 162
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
14-113 2.68e-03

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 39.35  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  14 HTPLVRLN----RIGNgRILAKVESRNPSFSVKCRiGA-NMIW----DAEKRGVlkpgvelVEPTSGN--TGIALAyvAA 82
Cdd:PRK09224  20 ETPLEKAPklsaRLGN-QVLLKREDLQPVFSFKLR-GAyNKMAqlteEQLARGV-------ITASAGNhaQGVALS--AA 88

                         90       100       110
                 ....*....|....*....|....*....|....
gi 493864743  83 ARGYKLTLTMPET---MSIERrklLKALGANLVL 113
Cdd:PRK09224  89 RLGIKAVIVMPVTtpdIKVDA---VRAFGGEVVL 119
eutB PRK07476
threonine dehydratase; Provisional
 14-114 2.84e-03

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 38.79  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  14 HTPLVR---LNRIGNGRILAKVESRNPSFSVKCRIGANMIW----DAEKRGVlkpgvelVEPTSGNTGIALAYVAAARGY 86
Cdd:PRK07476  19 RTPLVAsasLSARAGVPVWLKLETLQPTGSFKLRGATNALLslsaQERARGV-------VTASTGNHGRALAYAARALGI 91

                         90       100
                 ....*....|....*....|....*...
gi 493864743  87 KLTLTMPETMSIERRKLLKALGANLVLT 114
Cdd:PRK07476  92 RATICMSRLVPANKVDAIRALGAEVRIV 119
PRK08206 PRK08206
diaminopropionate ammonia-lyase; Provisional
 15-136 4.53e-03

diaminopropionate ammonia-lyase; Provisional


Pssm-ID: 236186  Cd Length: 399  Bit Score: 38.32  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864743  15 TPLVRLN----RIGNGRILAKVES-RNP---------SFSVKC-----------RIGANMIWDAEKRGVLKpGVELVEPT 69
Cdd:PRK08206  45 TPLVALPdlaaELGVGSILVKDESyRFGlnafkalggAYAVARllaeklgldisELSFEELTSGEVREKLG-DITFATAT 123

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493864743  70 SGNTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGA--KGMKGAIQKAEE---IVASDPA 136
Cdd:PRK08206 124 DGNHGRGVAWAAQQLGQKAVIYMPKGSSEERVDAIRALGAECIITDGNydDSVRLAAQEAQEngwVVVQDTA 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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