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Conserved domains on  [gi|493865080|ref|WP_006811784|]
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MULTISPECIES: phosphopyruvate hydratase [Enterobacter]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-430 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 850.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIaelnGTPGKYSMPVPMMNIINGGEHA 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYL----GGVNAKTLPVPMMNIINGGAHA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKD 240
Cdd:COG0148  157 DNNVDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 241 ITLAMDCAASEFYKDGKYVLAGEGnKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLF 320
Cdd:COG0148  237 IALALDVAASEFYKDGKYHLKGEG-KELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLF 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 321 VTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRS 400
Cdd:COG0148  316 VTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRS 395

                        410       420       430
                 ....*....|....*....|....*....|
gi 493865080 401 DRVAKYNQLIRIEEALGEKAPYNGRKEIKG 430
Cdd:COG0148  396 ERVAKYNQLLRIEEELGDAARYAGRSAFKR 425
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-430 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 850.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIaelnGTPGKYSMPVPMMNIINGGEHA 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYL----GGVNAKTLPVPMMNIINGGAHA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKD 240
Cdd:COG0148  157 DNNVDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 241 ITLAMDCAASEFYKDGKYVLAGEGnKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLF 320
Cdd:COG0148  237 IALALDVAASEFYKDGKYHLKGEG-KELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLF 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 321 VTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRS 400
Cdd:COG0148  316 VTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRS 395

                        410       420       430
                 ....*....|....*....|....*....|
gi 493865080 401 DRVAKYNQLIRIEEALGEKAPYNGRKEIKG 430
Cdd:COG0148  396 ERVAKYNQLLRIEEELGDAARYAGRSAFKR 425
eno PRK00077
enolase; Provisional
 1-432 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 823.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIaelnGTPGKYSMPVPMMNIINGGEHA 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYL----GGPNAKVLPVPMMNIINGGAHA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKD 240
Cdd:PRK00077 157 DNNVDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 241 ITLAMDCAASEFYKDGKYVLAGEGnkaFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLF 320
Cdd:PRK00077 237 IALALDCAASEFYKDGKYVLEGEG---LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLF 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 321 VTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRS 400
Cdd:PRK00077 314 VTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRS 393

                        410       420       430
                 ....*....|....*....|....*....|..
gi 493865080 401 DRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA 432
Cdd:PRK00077 394 ERIAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-431 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 712.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080    4 IVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIVGKD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   84 AKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNGtpgkYSMPVPMMNIINGGEHADNN 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNA----YVLPVPMMNIINGGAHADNN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  164 VDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITL 243
Cdd:TIGR01060 157 LDFQEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVAL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  244 AMDCAASEFY--KDGKYVLAGEgNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFV 321
Cdd:TIGR01060 237 ALDCAASEFYdeEDGKYVYKGE-NKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  322 TNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSD 401
Cdd:TIGR01060 316 TNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSE 395

                         410       420       430
                  ....*....|....*....|....*....|
gi 493865080  402 RVAKYNQLIRIEEALGEKAPYNGRKEIKGQ 431
Cdd:TIGR01060 396 RIAKYNQLLRIEEELGDSARYAGKNSFYRF 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-414 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 705.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   6 KVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIVGKDAK 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  86 DQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNgtpgKYSMPVPMMNIINGGEHADNNVD 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA----AYVLPVPMFNVINGGAHAGNKLD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 166 IQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKG--MNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITL 243
Cdd:cd03313  157 FQEFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 244 AMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTN 323
Cdd:cd03313  237 ALDVAASEFYDEGKYVYDSDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTN 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 324 TKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRV 403
Cdd:cd03313  317 PERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERT 396

                        410
                 ....*....|.
gi 493865080 404 AKYNQLIRIEE 414
Cdd:cd03313  397 AKYNQLLRIEE 407
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
143-431 4.87e-171

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 480.82  E-value: 4.87e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  143 KYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKG--MNTAVGDEGGYAPNLGSNA 220
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  221 EALAVIAEAVKAAGYELgkDITLAMDCAASEFY--KDGKYVLAGEGN-----KAFTSEEFTHFLEDLTKQYPIVSIEDGL 293
Cdd:pfam00113  81 EALDLIVEAIEKAGYKG--KIKIAMDVASSEFYnkKDGKYDLDFKGEksdksKKLTSAQLADLYEELVKKYPIVSIEDPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  294 DESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSG 373
Cdd:pfam00113 159 DEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSG 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 493865080  374 ETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQ 431
Cdd:pfam00113 239 ETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-430 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 850.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIaelnGTPGKYSMPVPMMNIINGGEHA 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYL----GGVNAKTLPVPMMNIINGGAHA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKD 240
Cdd:COG0148  157 DNNVDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 241 ITLAMDCAASEFYKDGKYVLAGEGnKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLF 320
Cdd:COG0148  237 IALALDVAASEFYKDGKYHLKGEG-KELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLF 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 321 VTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRS 400
Cdd:COG0148  316 VTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRS 395

                        410       420       430
                 ....*....|....*....|....*....|
gi 493865080 401 DRVAKYNQLIRIEEALGEKAPYNGRKEIKG 430
Cdd:COG0148  396 ERVAKYNQLLRIEEELGDAARYAGRSAFKR 425
eno PRK00077
enolase; Provisional
 1-432 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 823.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIaelnGTPGKYSMPVPMMNIINGGEHA 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYL----GGPNAKVLPVPMMNIINGGAHA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKD 240
Cdd:PRK00077 157 DNNVDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 241 ITLAMDCAASEFYKDGKYVLAGEGnkaFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLF 320
Cdd:PRK00077 237 IALALDCAASEFYKDGKYVLEGEG---LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLF 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 321 VTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRS 400
Cdd:PRK00077 314 VTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRS 393

                        410       420       430
                 ....*....|....*....|....*....|..
gi 493865080 401 DRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA 432
Cdd:PRK00077 394 ERIAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-431 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 712.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080    4 IVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIVGKD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   84 AKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNGtpgkYSMPVPMMNIINGGEHADNN 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNA----YVLPVPMMNIINGGAHADNN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  164 VDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITL 243
Cdd:TIGR01060 157 LDFQEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVAL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  244 AMDCAASEFY--KDGKYVLAGEgNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFV 321
Cdd:TIGR01060 237 ALDCAASEFYdeEDGKYVYKGE-NKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  322 TNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSD 401
Cdd:TIGR01060 316 TNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSE 395

                         410       420       430
                  ....*....|....*....|....*....|
gi 493865080  402 RVAKYNQLIRIEEALGEKAPYNGRKEIKGQ 431
Cdd:TIGR01060 396 RIAKYNQLLRIEEELGDSARYAGKNSFYRF 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-414 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 705.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   6 KVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIVGKDAK 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  86 DQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNgtpgKYSMPVPMMNIINGGEHADNNVD 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA----AYVLPVPMFNVINGGAHAGNKLD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 166 IQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKG--MNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITL 243
Cdd:cd03313  157 FQEFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 244 AMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTN 323
Cdd:cd03313  237 ALDVAASEFYDEGKYVYDSDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTN 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 324 TKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRV 403
Cdd:cd03313  317 PERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERT 396

                        410
                 ....*....|.
gi 493865080 404 AKYNQLIRIEE 414
Cdd:cd03313  397 AKYNQLLRIEE 407
PTZ00081 PTZ00081
enolase; Provisional
 1-424 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 549.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGfVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:PTZ00081   1 MSTIKSIKAREILDSRGNPTVEVDLTTEKG-VFRAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMID-LDGTEN-----KSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNGTPG-KYSMPVPMMNI 153
Cdd:PTZ00081  80 GKDVTDQKKLDKLMVEqLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKPTdKFVLPVPCFNV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 154 INGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAK-GMN-TAVGDEGGYAPNLGSNAEALAVIAEAVK 231
Cdd:PTZ00081 160 INGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKyGLDaTNVGDEGGFAPNIKDPEEALDLLVEAIK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 232 AAGYElGKdITLAMDCAASEFYKDGK--YVL-----AGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQ 304
Cdd:PTZ00081 240 KAGYE-GK-VKICMDVAASEFYDKEKkvYDLdfknpNNDKSNKLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAKL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 305 TKVLGDKIQLVGDDLFVTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLA 384
Cdd:PTZ00081 318 TAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLV 397

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 493865080 385 VGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNG 424
Cdd:PTZ00081 398 VGLGTGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAG 437
PLN00191 PLN00191
enolase
 1-424 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 523.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVgMAAAPSGASTGSREALELRDGDKsRFMGKGVLKAVGAVNGPIAQAIV 80
Cdd:PLN00191  25 MATITKVKARQIIDSRGNPTVEVDLHTSKGMF-RAAVPSGASTGIYEALELRDGDK-DYLGKGVLKAVKNVNEIIAPALI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNGTPgKYSMPVPMMNIINGGEHA 160
Cdd:PLN00191 103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAGNK-KLVLPVPAFNVINGGSHA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAK--GMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYElG 238
Cdd:PLN00191 182 GNKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKygQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT-G 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 239 KdITLAMDCAASEFY-KDGKYVL-----AGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKvlGDKI 312
Cdd:PLN00191 261 K-IKIGMDVAASEFYtKDKKYDLdfkeeNNDGSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTS--LEDV 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 313 QLVGDDLFVTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQI 392
Cdd:PLN00191 338 QIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQI 417

                        410       420       430
                 ....*....|....*....|....*....|..
gi 493865080 393 KTGSMSRSDRVAKYNQLIRIEEALGEKAPYNG 424
Cdd:PLN00191 418 KTGAPCRSERLAKYNQLLRIEEELGDEAVYAG 449
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
143-431 4.87e-171

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 480.82  E-value: 4.87e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  143 KYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGSEVFHNLAKVLKAKG--MNTAVGDEGGYAPNLGSNA 220
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  221 EALAVIAEAVKAAGYELgkDITLAMDCAASEFY--KDGKYVLAGEGN-----KAFTSEEFTHFLEDLTKQYPIVSIEDGL 293
Cdd:pfam00113  81 EALDLIVEAIEKAGYKG--KIKIAMDVASSEFYnkKDGKYDLDFKGEksdksKKLTSAQLADLYEELVKKYPIVSIEDPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  294 DESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSG 373
Cdd:pfam00113 159 DEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSG 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 493865080  374 ETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQ 431
Cdd:pfam00113 239 ETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
Enolase_N pfam03952
Enolase, N-terminal domain;
4-134 1.90e-74

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 228.80  E-value: 1.90e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080    4 IVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAIVGKD 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 493865080   84 AKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHI 134
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
PRK08350 PRK08350
hypothetical protein; Provisional
 1-419 4.07e-14

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 72.92  E-value: 4.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080   1 MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFvGMAAAPSgastgsrealelrDGDKSRFMGKGvLKAVGAVNGPIAQAIV 80
Cdd:PRK08350   1 MTVIENIIGRVAVLRGGKYSVEVDVITDSGF-GRFAAPI-------------DENPSLYIAEA-HRAVSEVDEIIGPELI 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  81 GKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNGTpgkySMPVPMMNIINgGEHA 160
Cdd:PRK08350  66 GFDASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTT----ELPVPILEFAE-DENF 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMiqpvgaktlkeavrmgsEVFHNLAKVLKAKGMNTAVGDEGgyapnlgsnaealavIAEAVKAAGYELGKD 240
Cdd:PRK08350 141 EYYVLVRDLM-----------------EITDVVDAVNKILENSKEVSLEG---------------LSKASEKAGDELGLE 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 241 ITLAMdcaasefykdgkyvlagEGNKAFTSEEFTHFLEDLTKQY--PIvsiedGLDESDWDGFAYQTKVLGDkiqlvGDD 318
Cdd:PRK08350 189 VALGI-----------------AQKREMETEKVLNLVEDNNIAYikPI-----GDEELFLELIAGTHGVFID-----GEY 241

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 319 LFVTNTKilkegIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIktgsMS 398
Cdd:PRK08350 242 LFRTRNI-----LDRRYYNALSIKPINLGTLTDLYNLVNDVKSERITPILAEAKYESADEALPHLAVGLRCPAM----LI 312

                        410       420
                 ....*....|....*....|.
gi 493865080 399 RSDRVAKYNQLIRIEEALGEK 419
Cdd:PRK08350 313 HKDSVEKINELNRIAEDLGER 333
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 198-387 3.08e-12

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 65.81  E-value: 3.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 198 KAKGMNTAVGDEGGYAPNLgsnaEALAVIaEAVKAAGYELGKDITLAMDCAASEFYKDGKyvlagegnkaftseEFTHFL 277
Cdd:cd00308   57 KALGVPLAELLGGGSRDRV----PAYGSI-ERVRAVREAFGPDARLAVDANGAWTPKEAI--------------RLIRAL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 278 EDltkqYPIVSIEDGLDESDWDGFAYQTKVLGdkIQLVGDDLFVTNTKILkEGIEKGIVNSILIKFNQIGSLTETLAAIK 357
Cdd:cd00308  118 EK----YGLAWIEEPCAPDDLEGYAALRRRTG--IPIAADESVTTVDDAL-EALELGAVDILQIKPTRVGGLTESRRAAD 190

                        170       180       190
                 ....*....|....*....|....*....|.
gi 493865080 358 MAKDAGYTAVISHRSG-ETEDATIADLAVGT 387
Cdd:cd00308  191 LAEAFGIRVMVHGTLEsSIGTAAALHLAAAL 221
PTZ00378 PTZ00378
hypothetical protein; Provisional
 84-416 3.84e-08

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 55.27  E-value: 3.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080  84 AKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLFEHIAELNGTPG---KYSMPVPMMNIINGGEHA 160
Cdd:PTZ00378 124 ARDQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRSVPLFQYLRALFGSLTsveTFSMPQLCITFFGPGNPS 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 161 DNNVDIQEFMIQPV--GAKTLKEAVRMGSEVFHNLAKVlkakgMNTAVGDEGGYAPNLGSN-AEALAVIAEAVKAAGYEL 237
Cdd:PTZ00378 204 TARLALKSVLFSPVmpSGTVLRERMQKIFAAFHHFCQS-----HNSSVRSDGSLHWDGFANlTDAVKLATEALRAVQLTP 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 238 GKDITLAMDCAASEF------------YKDGK------YVLAGeGNKAFTSEEFTHFLEDLTKQYP--IVSIEDglDESD 297
Cdd:PTZ00378 279 GTDVCLGLRMAASTTrvpatavadggaWKEAKddcevlYSLFP-GEPDVTGDQLSEYVREQLQAVPdiVVYVED--THCD 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493865080 298 WDGFAYQ--TKVLGDKIQLVGDDLFV-TNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAK-DAGYTAVISHRSG 373
Cdd:PTZ00378 356 EDTFGLQrlQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIVLNPCAIGTLSDVVEIVRAVGeDEGRAVTVLVQTL 435

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 493865080 374 ETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEAL 416
Cdd:PTZ00378 436 AGNAATAAHLAVAMGARFLCSGGLFSAHQCEVVSQLASRQDEL 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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