|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
11-891 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1132.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 11 DLSALDGDIRRWWDQEEVFEASTAARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHG 90
Cdd:COG0060 17 NLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCHG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 91 LPVEIEVEKELGlKSREDIENYGIAEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQ 170
Cdd:COG0060 97 LPIELKVEKELG-IKKKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 171 GLLYKGHKIHWYSPGSGTVLSSHEVslGYKEVQDPSITVKFFLEDEP------DVAILAWTTTPWTMPSNVALAVGPNIE 244
Cdd:COG0060 176 GLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEKalllleDAYLVIWTTTPWTLPANLAVAVHPDID 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 245 YAKARAEDGSVYIVAKACVAATLG----ENAEILETFGADALIGKRYKPPydcFADHPEADQAWRVIAADFITTDDGTGI 320
Cdd:COG0060 254 YVLVEVTGGERLILAEALVEAVLKelgiEDYEVLATFKGAELEGLRYEHP---FYYVVGYDRAHPVILGDYVTTEDGTGI 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 321 AHEAPAFGADDFRVTSAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTP 400
Cdd:COG0060 331 VHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTP 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 401 LMNYPVESWFVATQQNKDKLVAYNDRINWFPAHvGTGRFGDWLENNVDWALSRHRFWGTPLPIWVNDnNPDEIV----VI 476
Cdd:COG0060 411 LIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCE-DCGELHrteeVI 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 477 GSIAELREYAGDQVADDdtLDLHKPQVDAITWTAEDGGTMRRVPEIIDVWFDSGAMPFAQWhypfENQErfEANFPADFI 556
Cdd:COG0060 489 GSVAELLEEEGADAWFE--LDLHRPFLDETLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENRE--ELHFPADFY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 557 CEGVDQTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLAnSPPWDNT 636
Cdd:COG0060 561 LEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVAS-SDYWGDL 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 637 KYADRGLRETRtKVFGTLENVYSFFAtyANIDGFTADTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAV 716
Cdd:COG0060 640 RFSDEILKEVR-DVYRRLRNTYRFLL--ANLDDFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRAL 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 717 ERFI-DALSNWYIRRSRARFWagaradaggdASEAEVADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQLVNESGar 795
Cdd:COG0060 717 HNFCvEDLSNWYLDISKDRLY----------TEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAE-- 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 796 ASVHLADFPAADAALIDADLERRMALARAIVANAL----ALRNEaGLnVRQPLARILVVEEADVARADVDAIAAIVRDEI 871
Cdd:COG0060 785 ESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKE-KL-IRQPLEAAVVLYADEELAAALESLGDLLAEEL 862
|
890 900
....*....|....*....|
gi 493970654 872 NVDAIEFVAGEGDLVKRSAK 891
Cdd:COG0060 863 NVSEVELVDDAEDLGKDALK 882
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
8-861 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 937.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 8 KPLDLSALDGDIRRWWDQEEVFEASTAARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWD 87
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 88 THGLPVEIEVEKELGLKSREDIENYGIAEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQL 167
Cdd:TIGR00392 84 THGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 168 HEQGLLYKGHKIHWYSPGSGTVLSSHEVSL--GYKEVQDPSITVKFFLEDEPD-------VAILAWTTTPWTMPSNVALA 238
Cdd:TIGR00392 164 HEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKKtylkvklSSLLIWTTTPWTLPSNLAIA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 239 VGPNIEYAKARAEDGS-VYIVAKACV---AATLGENAEILETFGADALIGKRYKPPYDCFADHPEaDQAWRVIAADFITT 314
Cdd:TIGR00392 244 VHPDFEYALVQDNTKVeYFILAKKLVeklYNKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLK-EGAPVVIGGDHVTT 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 315 DDGTGIAHEAPAFGADDFRVTSAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVAR-------DLKDRGLLFSQQVT 387
Cdd:TIGR00392 323 EDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVKDADKDIIKankiiieQLKDKGLLLKAEKI 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 388 VHNYPHDWRKGTPLMNYPVESWFVATQQNKDKLVAYNDRINWFPAHvGTGRFGDWLENNVDWALSRHRFWGTPLPIWVnD 467
Cdd:TIGR00392 403 THSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEW-GEGRFGNWLENRPDWCISRQRYWGIPIPIWY-C 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 468 NNPDEIVVIGSIAELREYAGDQVADDDTLDLHKPQVDAITWTAEDGGTMRRVPEIIDVWFDSGAMPFAQWHYPFENqERF 547
Cdd:TIGR00392 481 EDTGEPIVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKSGDGGEYRRVPDVLDVWFDSGSMPYASIHYPFEN-EKF 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 548 EANFPADFICEGVDQTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMl 627
Cdd:TIGR00392 560 KEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYV- 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 628 ANSPPWDNTKYADRGLRETRTKVFGTLENVYSFFATYANIDGFTADTPAPAVAERPELDRWILSRLQSTAAEASAALDEY 707
Cdd:TIGR00392 639 ASSDPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYANLDKFDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEALEKY 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 708 NPTRAARAVERFID-ALSNWYIRRSRARFWagaradaggdaSEAEVADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYG 786
Cdd:TIGR00392 719 NFHKVLRALQDFIVeELSNWYIRIIRDRLY-----------CEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQ 787
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493970654 787 QLVNESGARaSVHLADFPAADAALIDADLERRMALARAIVANALALRNEAGLNVRQPLARILVVEEADVARADVD 861
Cdd:TIGR00392 788 NLPGGEEEE-SVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKAVE 861
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
6-1060 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 846.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 6 EHKPLDLSALDGDIRRWWDQEEVFEASTAARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAG 85
Cdd:PLN02882 4 EGKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 86 WDTHGLPVEIEVEKELGLKSREDIENYGIAEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLK 165
Cdd:PLN02882 84 WDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 166 QLHEQGLLYKGHKIHWYSPGSGTVLSSHEVSLGYKEVQDPSITVKFFLEDEPD-VAILAWTTTPWTMPSNVALAVGPNIE 244
Cdd:PLN02882 164 QLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIVGDPDnASFVAWTTTPWTLPSNLALCVNPNFT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 245 YAKARAED-GSVYIVAKACVAA---------------TLGENAEILETFGADALIGKRYKPPYDCFADhpEADQAWRVIA 308
Cdd:PLN02882 244 YVKVRNKYtGKVYIVAESRLSAlptakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSE--FSDTAFRVVA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 309 ADFITTDDGTGIAHEAPAFGADDFRVTSAEG-------MPVfnPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLL 381
Cdd:PLN02882 322 DDYVTDDSGTGVVHCAPAFGEDDYRVCLANGiiekggnLPV--PVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 382 FSQQVTVHNYPHDWRKGTPLMNYPVESWFVATQQNKDKLVAYNDRINWFPAHVGTGRFGDWLENNVDWALSRHRFWGTPL 461
Cdd:PLN02882 400 VKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 462 PIWVNDNNpDEIVVIGSIAELREYAGDQVAdddtlDLHKPQVDAITWTAEDG---GTMRRVPEIIDVWFDSGAMPFAQWH 538
Cdd:PLN02882 480 PIWISDDG-EEVVVIGSIAELEKLSGVKVT-----DLHRHFIDHITIPSSRGpefGVLRRVDDVFDCWFESGSMPYAYIH 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 539 YPFENQERFEANFPADFICEGVDQTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHG 618
Cdd:PLN02882 554 YPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 619 ADVIRWYmLANSPpwdntkyADRG--LRETRTKVFGTLE-------NVYSFFATYA---NIDGFTADTPAPAVAERPE-- 684
Cdd:PLN02882 634 ADALRLY-LINSP-------VVRAepLRFKEEGVFGVVKdvflpwyNAYRFLVQNAkrlEVEGGAPFVPLDLAKLQNSan 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 685 -LDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALSNWYIRRSRARFwagaRADAGGDaseaevaDKRAAYHTTL 763
Cdd:PLN02882 706 vLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRL----KGRTGEE-------DCRTALSTLY 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 764 TCLRDVAAMMAPIAPFFADWLYGQLVNES-GARASVHLADFPAADAALIDADLERRMALARAIVANALALRNEAGLNVRQ 842
Cdd:PLN02882 775 NVLLTSCKVMAPFTPFFTEVLYQNLRKVLpGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKT 854
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 843 PLARILVVEeadvarADVDAIAAI-------VRDEINVDAIEFVAGEGDLVKRSAKPNFKTLGKRLGKKMKAVAGAVAAL 915
Cdd:PLN02882 855 PLKEMVVVH------PDAEFLDDItgklkeyVLEELNVRSLVPCNDPLKYASLRAEPNFSVLGKRLGKSMGLVAKEVKAM 928
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 916 DDEAIARYMRDMRLIVtadgEDIELGEGDLLV-----SAEGV--EGWLVGREDGVTVALDSTLTDSLRERGLAREVINRV 988
Cdd:PLN02882 929 SQDDILEFEKAGEVTI----AGHTLKAGDIKVvrdfkRPEGVskEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRI 1004
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 989 QRLRKQADFHVADRIRVQYRADDE-----LAKAIESHRTVIaRETLAEAYEPNAQ-PSGEV----EQAFDIDGAQITLAL 1058
Cdd:PLN02882 1005 QKLRKKAGLEPTDKVEVFFESLDEvdesaLSQVLKSQAQYI-RESLGSPLLPSSMmPSHAVviaeESFHGVSGLSFKISL 1083
|
..
gi 493970654 1059 AR 1060
Cdd:PLN02882 1084 AR 1085
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
19-1013 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 607.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 19 IRRWWDQEEVFEASTAARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVE 98
Cdd:PTZ00427 81 VLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 99 KELGLKSREDIENYGIAEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGHK 178
Cdd:PTZ00427 161 KENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFK 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 179 IHWYSPGSGTVLSSHEVSLGYKEVQDPSITVKFFL-EDEPDVA------------------------------------- 220
Cdd:PTZ00427 241 VMPYSCKCNTPISNFELNLNYKDTPDPSIIISFVLcSDFPKVEeecnieedkqllgekysvlynnkrensnngnnnstnn 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 221 --------ILAWTTTPWTMPSNVALAVGPNIEYAKA-RAEDGSVYIVAKACVAATLGE------NAEILETFGADALIGK 285
Cdd:PTZ00427 321 vcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIhHVKSNRVVIVGECRLEWIMKElkwnveDLKIVNRFKGKELKGL 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 286 RYKPPYDCFAD-HPEADQAWRVIAADFITTDDGTGIAHEAPAFGADDFRVTSAEGM--P----VFNPIERNGHFQADFPL 358
Cdd:PTZ00427 401 RYKPLFTNFYEkYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPekniFIDPLDANGYFTNEVEE 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 359 VGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPLMNYPVESWFVATQQNKDKLVAYNDRINWFPAHVGTGR 438
Cdd:PTZ00427 481 VQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIKEKK 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 439 FGDWLENNVDWALSRHRFWGTPLPIWVnDNNPDEIVVIGSIAELREYAGDQvaddDTLDLHKPQVDAITWTAEDGGT--- 515
Cdd:PTZ00427 561 FHNWIKDAKDWCISRNRYWGTPIPIWA-DEKMETVICVESIKHLEELSGVK----NINDLHRHFIDHIEIKNPKGKTypk 635
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 516 MRRVPEIIDVWFDSGAMPFAQWHYPFENQ-ERFEANFPADFICEGVDQTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLD 594
Cdd:PTZ00427 636 LKRIPEVFDCWFESGSMPYAKVHYPFSTEkEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLA 715
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 595 ANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLaNSPP--WDNTKYADRGLRETRTKVFGTLENVYSFFATYA------N 666
Cdd:PTZ00427 716 SDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI-NSVAvrAENLKFQEKGVNEVVKSFILPFYHSFRFFSQEVtryeclN 794
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 667 IDGFTADTPApAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALSNWYIRRSRARFwagaRADAGGD 746
Cdd:PTZ00427 795 KKQFLFNTDY-IYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRM----RGSLGEE 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 747 aseaevaDKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL-----------VNESGA-----------RASVHLADFP 804
Cdd:PTZ00427 870 -------NCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLrrvkstnehneNNETGNtkegdlnrgviHKSVHFIMLP 942
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 805 AADAALI-DADLERRMALARAIVANALALRNEAGLNVRQPLARILVVEEADVARADVDAIAAIVRDEINVDAIEFvAGEG 883
Cdd:PTZ00427 943 QVDEKYIiDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVEC-SNDT 1021
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 884 DLVKRSAKPNFKTLGKRLGKKMKAVAGAVAALDDEAIARYMRDMRLIVtadgEDIELGEGDLLVSAEGV---EGWLVGRE 960
Cdd:PTZ00427 1022 SCLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITL----DNVTLEGDDIIIQMKPNfqnDNTDIISN 1097
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....
gi 493970654 961 DGVTVALDSTLTDSLRERGLAREVINRVQRLRKQADFHVADRIRVQ-YRADDEL 1013
Cdd:PTZ00427 1098 NYVTILMDFTTDQQLENMASARELCNHIQKMRKNLSLNQNSPVKMHvYIADDTL 1151
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
18-632 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 585.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 18 DIRRWWDQEEVFEASTAARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEV 97
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 98 EKELGLKSREDIENYGIAEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGH 177
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 178 KIHWYSPGSGTVLSSHEVSlgYKEVQDPSITVKFFLEDEPDVAILAWTTTPWTMPSNVALAVGPNIEYAKaraeDGSVYI 257
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVE--YKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI----TGEGYI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 258 VAKACVAAT--LGENAEILETFGADALIGKRYKPPYdcfadhpeADQAWRVIAADFITTDDGTGIAHEAPAFGADDFRVT 335
Cdd:pfam00133 235 LAEALLKSLykKGTDKKILEDFRGKELEGKEAIHPF--------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 336 SAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPLMNYPVESWFVATQQ 415
Cdd:pfam00133 307 QRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDE 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 416 NKDKLVAYNDRINWFPaHVGTGRFGDWLENNVDWALSRHRFWGTPLPIWVnDNNPDEIVVIGSIAELReyAGDQVADDDT 495
Cdd:pfam00133 387 LADQALEAVEKVQFVP-KSGEKRYFNWLANIQDWCISRQRWWGHPIPAWV-SKDTEEVVCRGELFELV--AGRFEEEGSI 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 496 LDLHKPQVDAITWTAedgGTMRRVPEIIDVWFDSGAMPFAQWHYPFENQERFEANFPADFICEGVDQTRGWFYSLHAIGT 575
Cdd:pfam00133 463 KWLHREAKDKLGYGK---GTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLST 539
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 493970654 576 LIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYmLANSPP 632
Cdd:pfam00133 540 ALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLW-LANSDY 595
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
40-638 |
5.15e-126 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 387.36 E-value: 5.15e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 40 PTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEKELGLKSREDIENYGIAEYNA 119
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 120 ACRESVLRYKTQWDDLTRRIGFWADldapyvtFSNEYIesvwwllkqlheqgllykghkihwyspgsgtvlsshevslgy 199
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVD-------WENPYK------------------------------------------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 200 kevqdpsitvkffledepdvailawTTTPWTMPSnvalavgpnieyakaraedgsvyivakacvaatlgenaeILETFGa 279
Cdd:cd00818 112 -------------------------TMDPEYMES---------------------------------------VWWVFK- 126
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 280 daligkrykppydcfadhpeadQAWrviaadfittddgtgiaheapafgaddfrvtsaegmpvfnpiernghfqadfplv 359
Cdd:cd00818 127 ----------------------QLH------------------------------------------------------- 129
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 360 gglwfkdadkpvardlkDRGLLFSQQVTVHnyphdWrkgtPLMNYPVESWFVATQQNKDKLVAYNDRINWFPAHVGTgRF 439
Cdd:cd00818 130 -----------------EKGLLYRGYKVVP-----W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RF 182
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 440 GDWLENNVDWALSRHRFWGTPLPIWVNDNNPDEIVvigsiaelreyagdqvadddtldlhkpqvdaitwtaedggtmRRV 519
Cdd:cd00818 183 GNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV------------------------------------------RRV 220
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 520 PEIIDVWFDSGAMPFAQWHYPFENqERFEANFPADFICEGVDQTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEK 599
Cdd:cd00818 221 PDVLDVWFDSGSMPYAQLHYPFEN-EDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRK 299
|
570 580 590
....*....|....*....|....*....|....*....
gi 493970654 600 MSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKY 638
Cdd:cd00818 300 MSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
19-804 |
1.40e-112 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 372.18 E-value: 1.40e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 19 IRRWWDQEEVFEAsTAARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVE 98
Cdd:PLN02843 12 IQKLWEENQVYKR-VSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 99 KELGLKSREDIenyGIAEYNAACRESVLR-YKTQWDDLtRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGH 177
Cdd:PLN02843 91 QSLDQEARKEL---TPIKLRAKAAKFAKKtVDTQRESF-KRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 178 K-IHWySPGSGTVLSshEVSLGYKE------------VQDPSITVKFFLEDE-PDVAILAWTTTPWTMPSNVALAVGPNI 243
Cdd:PLN02843 167 KpVHW-SPSSRTALA--EAELEYPEghvsksiyvafpVVSPSETSPEELEEFlPGLSLAIWTTTPWTMPANAAVAVNDKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 244 EYA----------------KARAEDGSVY--------IVAKACV---AATLGENAEILETFGADALIGKRYKPPYDCfAD 296
Cdd:PLN02843 244 QYSvvevqsfsedestsggNKKKRPGNVLkeqqklflIVATDLVpalEAKWGVKLVVLKTFPGSDLEGCRYIHPLYN-RE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 297 HPEadqawrVIAADFITTDDGTGIAHEAPAFGADDFRVTSAEGMPVFNPIERNGHFQADF-PLVGGLWFKDADKPVARDL 375
Cdd:PLN02843 323 SPV------VIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAgQFSGLSVLGEGNAAVVEAL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 376 KDRGLLFSQQVTVHNYPHDWRKGTPLMNYPVESWFVATQQNKDKLVAYNDRINWFPaHVGTGRFGDWLENNVDWALSRHR 455
Cdd:PLN02843 397 DEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIP-AQGENRIRAMVSGRSDWCISRQR 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 456 FWGTPLPIW--VNDNNP----DEIVVIGSIaeLREYAGDQVADDDTLDLHKPQVDAitwTAEDggtMRRVPEIIDVWFDS 529
Cdd:PLN02843 476 TWGVPIPVFyhVETKEPlmneETIAHVKSI--VAQKGSDAWWYMDVEDLLPEKYRD---KASD---YEKGTDTMDVWFDS 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 530 GampfAQWHYPFenQERFEANFPADFICEGVDQTRGWFYS--LHAIGTliKDSPAYKNVVVNGLLLDANGEKMSKSKGNT 607
Cdd:PLN02843 548 G----SSWAGVL--GSREGLSYPADLYLEGSDQHRGWFQSslLTSVAT--KGKAPYKSVLTHGFVLDEKGFKMSKSLGNV 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 608 VDPFEALD---------EHGADVIR-WymLANSPPWDNTKYADRGLRETRT---KVFGTLENVYSffatyaNIDGFTADT 674
Cdd:PLN02843 620 VDPRLVIEggknqkqepAYGADVLRlW--VASVDYTGDVLIGPQILKQMSDiyrKLRGTLRYLLG------NLHDWKPDN 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 675 pAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERF-IDALSNWYIRRSRARFWAGARADAggdaseaeva 753
Cdd:PLN02843 692 -AVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFtIVDLSNFYLDVAKDRLYVGGTTSF---------- 760
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....
gi 493970654 754 dKRAAYHTTL-TCLRDVAAMMAPIAPFFAD--WLYGQLVNESGARASVHLADFP 804
Cdd:PLN02843 761 -TRRSCQTVLaAHLLSLLRAIAPILPHLAEdaWQNLPFQEDGSAAESVFEAGWP 813
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
11-918 |
8.55e-111 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 364.77 E-value: 8.55e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 11 DLSALDGDIRRWWDQEEVFEAStaARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHG 90
Cdd:TIGR00422 6 DPHEVEKKWYKKWEKSGFFKPD--GNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 91 LPVEIEVEKELGL--KSREDienYGIAEYNAACRESVLRY----KTQWddltRRIGFWADLDAPYVTFSNEYIESVWWLL 164
Cdd:TIGR00422 84 IATQVKVEKKLGAegKTKHD---LGREEFREKIWEWKEESggtiKNQI----KRLGASLDWSRERFTMDEGLSKAVKEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 165 KQLHEQGLLYKG-HKIHWySPGSGTVLSSHEVSlgYKEVQDPSITVKFFLEDEPDVAILAWTTTPWTMPSNVALAVGPNI 243
Cdd:TIGR00422 157 VRLYEKGLIYRGeYLVNW-DPKLNTAISDIEVE--YKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPED 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 244 EYAKAraedgsvyivakacvaatlgenaeiletfgadaLIGKrykppydcFADHPEADQAWRVIAADFITTDDGTGIAHE 323
Cdd:TIGR00422 234 ERYKH---------------------------------LIGK--------KVILPLTGRKIPIIADEYVDMEFGTGAVKV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 324 APAFGADDFRVTSAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPLMN 403
Cdd:TIGR00422 273 TPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEP 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 404 YPVESWFVATQQNKDKLV--AYNDRINWFPAHVGTgRFGDWLENNVDWALSRHRFWGTPLPIWVNDNNpDEIVVIGSIAE 481
Cdd:TIGR00422 353 LLSKQWFVKVEKLADKALeaAEEGEIKFVPKRMEK-RYLNWLRNIKDWCISRQLIWGHRIPVWYCKEC-GEVYVAKEEPL 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 482 LReyagDQVADDDTLDLhkpqvdaitwtaedggtmRRVPEIIDVWFDSGAMPF--AQWHypfENQERFEANFPADFICEG 559
Cdd:TIGR00422 431 PD----DKTNTGPSVEL------------------EQDTDVLDTWFSSSLWPFstLGWP---DETKDLKKFYPTDLLVTG 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 560 VDQTRGW-FYSLHAIGTLIKDSPaYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPP------ 632
Cdd:TIGR00422 486 YDIIFFWvARMIFRSLALTGQVP-FKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPgddinf 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 633 -WDNTKYADRGLRetrtKVFgtleNVYSFfaTYANIDGfTADTPAPAVAERPeLDRWILSRLQSTAAEASAALDEYNPTR 711
Cdd:TIGR00422 565 dWKRVESARNFLN----KLW----NASRF--VLMNLSD-DLELSGGEEKLSL-ADRWILSKLNRTIKEVRKALDKYRFAE 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 712 AARAVERFI-DALSNWYIRRSRARFWAGaradaggdaseaEVADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQLvn 790
Cdd:TIGR00422 633 AAKALYEFIwNDFCDWYIELVKYRLYNG------------NEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHF-- 698
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 791 eSGARASVHLADFPAADAALIDADLERRMALARAIVANALALRNEAGLNVRQPLARILVVEEADVARaDVDAIAAIVRDE 870
Cdd:TIGR00422 699 -KEGADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAE-RLKLNAVDIKGA 776
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 493970654 871 INVDAIEFVAG--EGDLVKRSAKPNFKTLG--KRLGKKMKAVAGAVAALDDE 918
Cdd:TIGR00422 777 INFSEVEVVIEkpEVTEAVVELVPGFEIIIpvKGLINKAKELARLQKQLDKE 828
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
20-886 |
1.29e-95 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 321.76 E-value: 1.29e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 20 RRWWDQEEVFEASTAARadGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEK 99
Cdd:PRK13208 20 QKIWEEEGTYKFDPDER--KPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPTERKVEK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 100 ELGLK----SREdienygiaEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYK 175
Cdd:PRK13208 98 YYGIRkddiSRE--------EFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 176 G-HKIHWySPGSGTVLSSHEVslGYKEVQDPSITVKFFLEDEPDVAIlAwTTTPWTMPSNVALAVGPNIE-YAKaraedg 253
Cdd:PRK13208 170 AeAPVLW-CPRCETAIAQAEV--EYREREGKLNYIKFPVEDGEEIEI-A-TTRPELLPACVAVVVHPDDErYKH------ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 254 svyivakacvaatlgenaeiletfgadaLIGKRYKPPYdcFAD------HPEADQawrviaaDFittddGTGIAHEApAF 327
Cdd:PRK13208 239 ----------------------------LVGKTAIVPL--FGVevpilaDPLVDP-------DF-----GTGAVMIC-TF 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 328 GaD--DFRVTSAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPLMNYP 405
Cdd:PRK13208 276 G-DktDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILV 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 406 VESWFVATQQNKDKLVAYNDRINWFPAHVGTgRFGDWLEN-NVDWALSRHRFWGTPLPIWVNDNnPDEIVVigsiAELRE 484
Cdd:PRK13208 355 TRQWFIKVLDLKEELLERGKEINWYPEHMRV-RLENWIEGlNWDWCISRQRYFGTPIPVWYCKD-CGHPIL----PDEED 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 485 YAGDQVADDDTLDlHKPQVDAITWTAEdggtmrrvPEIIDVWFDSGAMPFAQWHYPfENQERFEANFPADFICEGVDQTR 564
Cdd:PRK13208 429 LPVDPTKDEPPGY-KCPQCGSPGFEGE--------TDVMDTWATSSITPLIVTGWE-RDEDLFEKVFPMDLRPQGHDIIR 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 565 GW-FYSL---HaigtLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRwYMLANSPPWDNTKYAD 640
Cdd:PRK13208 499 TWlFYTIlraY----LLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YWAASARLGSDTPFDE 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 641 RGLRETR---TKVFgtleNVYSFfatyanIDGFTADTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVE 717
Cdd:PRK13208 574 KQVKIGRrllTKLW----NASRF------VLHFSADPEPDKAEVLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIE 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 718 RFIdalsnW------YIRRSRARfwagaradAGGDASEAEVADKRAAYHTTL-TCLRdvaaMMAPIAPFFADWLYGQLVN 790
Cdd:PRK13208 644 SFF-----WhvfcddYLELVKSR--------AYGEDEEEEQKSARYTLYTVLdTLLR----LLAPFLPFITEEVWSWLYG 706
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 791 EsgaraSVHLADFPAADAALIDADLERRMALARAIVAnalALR---NEAGLNVRQPLARILVVeeADVARADVDAIAAIV 867
Cdd:PRK13208 707 G-----SVHRASWPEPDEELIDEEDEELGELAKEILS---AVRkykSEAGLSLNAPLKKVEVY--GPADLELLEAAEEDL 776
|
890
....*....|....*....
gi 493970654 868 RDEINVDAIEFVAGEGDLV 886
Cdd:PRK13208 777 KAAGNIEELELVEGDPELE 795
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
864-1061 |
1.64e-84 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 271.27 E-value: 1.64e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 864 AAIVRDEINVDAIEFVAGEGDLVKRSAKPNFKTLGKRLGKKMKAVAGAVAALDDEAIARYMRDMRLIVTADGEDIELGEG 943
Cdd:pfam19302 1 EDIIKEELNVKEVEFGADESELVEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTLTIDVDGEEIELTSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 944 DLLVSAEGVEGWLVGREDGVTVALDSTLTDSLRERGLAREVINRVQRLRKQADFHVADRIRVQYRADDELAKAIESHRTV 1023
Cdd:pfam19302 81 DLLVTRQGKEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEMLEAAIEKFEDY 160
|
170 180 190
....*....|....*....|....*....|....*...
gi 493970654 1024 IARETLAEAYEPNAQPSGEveqAFDIDGAQITLALARV 1061
Cdd:pfam19302 161 IKKETLAVEIIFNEEKEYT---EVDINGEKLKIAVEKV 195
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
640-830 |
4.36e-66 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 220.12 E-value: 4.36e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 640 DRGLRETRTKVFGTLENVYSFFATYANIDGFTADTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERF 719
Cdd:cd07961 3 EKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 720 IDALSNWYIRRSRARFWAgaradaggdasEAEVADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQLVNESGARA-SV 798
Cdd:cd07961 83 IDELTNWYIRRNRKRFWG-----------EEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPeSV 151
|
170 180 190
....*....|....*....|....*....|..
gi 493970654 799 HLADFPAADAALIDADLERRMALARAIVANAL 830
Cdd:cd07961 152 HLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
21-881 |
8.86e-56 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 211.00 E-value: 8.86e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 21 RW---WDQEEVFEASTAARaDGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEV 97
Cdd:PRK14900 27 RWypfWQERGYFHGDEHDR-TRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 98 EKELGL---KSREDIENYGIAEYNAACREsvlRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLY 174
Cdd:PRK14900 106 EKELKKtekKSRHDLGREAFLERVWAWKE---QYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 175 KGHKIHWYSPGSGTVLSSHEVSlgYKEVQDPSI-TVKFFLEDEpDVAILAWTTTPWTMPSNVALAVGPNIEYAKAraedg 253
Cdd:PRK14900 183 REKKLINWCPDCRTALSDLEVE--HEEAHQGELwSFAYPLADG-SGEIVVATTRPETMLGDTAVAVHPLDPRYMA----- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 254 svyivakacvaatlgenaeiletfgadaLIGKRYKppydcfadHPEADQAWRVIA-ADFITTDDGTGIAHEAPAFGADDF 332
Cdd:PRK14900 255 ----------------------------LHGKKVR--------HPITGRTFPIVAdAILVDPKFGTGAVKVTPAHDFNDF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 333 RVTSAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPLMNYPVESWFV- 411
Cdd:PRK14900 299 EVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVr 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 412 ----------ATQQNKDKLVAYndriNWfpahvgTGRFGDWLENNVDWALSRHRFWGTPLPIWVndnNPDEIVVIGsiae 481
Cdd:PRK14900 379 ieplarpaieAVEQGRTRFIPE----QW------TNTYMAWMRNIHDWCISRQLWWGHQIPAWY---CPDGHVTVA---- 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 482 lREyagdqvadddtldlhKPQVDAITWTAEdggtMRRVPEIIDVWFDSGAMPFAQWHYPfENQERFEANFPADFICEGVD 561
Cdd:PRK14900 442 -RE---------------TPEACSTCGKAE----LRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHD 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 562 QTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYA-D 640
Cdd:PRK14900 501 IIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAkE 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 641 R--GLRETRTKVFGTlenvySFFAtYANIDGFTADTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVER 718
Cdd:PRK14900 581 RieGYRAFANKLWNA-----SRFA-LMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYA 654
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 719 FIDA-LSNWYIRRSRARFWagaradagGDASEAevadKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL---VNESGA 794
Cdd:PRK14900 655 FVWHeLCDWYIELAKEALA--------SEDPEA----RRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLraqVGASAW 722
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 795 RASVHLADFPaadaaLIDADLERRMALARAIVANALALRNEAGLNVRQPLARILVVEEADVARADVDAIAAIVRDEI--- 871
Cdd:PRK14900 723 ADSVLAAEYP-----RKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLGAQAPVEIAVADPALRDLLQAGELarv 797
|
890
....*....|....
gi 493970654 872 ----NVDAIEFVAG 881
Cdd:PRK14900 798 hrvaGVEGSRLVVA 811
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
59-880 |
9.13e-56 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 209.19 E-value: 9.13e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 59 HVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEKEL---GlKSREDI-------------ENYG--Iaeynaa 120
Cdd:PRK05729 55 HALNNTLQDILIRYKRMQGYNTLWLPGTDHAGIATQMVVERQLaaeG-KSRHDLgrekflekvwewkEESGgtI------ 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 121 cresvlryKTQWddltRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGHKI-HWySPGSGTVLSSHEVSlgY 199
Cdd:PRK05729 128 --------TNQL----RRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLvNW-DPKLQTALSDLEVE--Y 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 200 KEVQDPSITVKFFLEDEPDVAILAwTTTPWTMPSNVALAVGPNIE-YAKaraedgsvyivakacvaatlgenaeiletfg 278
Cdd:PRK05729 193 KEVKGKLWHIRYPLADGSDYLVVA-TTRPETMLGDTAVAVNPEDErYKH------------------------------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 279 adaLIGKrykppydcFADHPEADQAWRVIAADFITTDDGTGI-----AHeapafgaD--DFRVTSAEGMPVFNPIERNGH 351
Cdd:PRK05729 241 ---LIGK--------TVILPLVGREIPIIADEYVDPEFGTGAvkitpAH-------DpnDFEVGKRHNLPMINIMDEDGT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 352 FQADFPLVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPlmnypVES-----WFVATQQNKDKLVAY--N 424
Cdd:PRK05729 303 INENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVV-----IEPylsdqWFVKMKPLAKPALEAveN 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 425 DRINWFPAHvGTGRFGDWLENNVDWALSRHRFWGTPLPIWVNDNNpdEIVVIGSIAELREyAGDQVADDDTLDlhkpqvd 504
Cdd:PRK05729 378 GEIKFVPER-WEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDG--EVYVGREEPEARE-KALLTQDEDVLD------- 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 505 aitwtaedggTmrrvpeiidvWFDSGAMPFAQ--WHypfENQERFEANFPAD----------FicegvdqtrgW-----F 567
Cdd:PRK05729 447 ----------T----------WFSSALWPFSTlgWP---EKTEDLKRFYPTSvlvtgfdiifF----------WvarmiM 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 568 YSLHAIGTLikdsPaYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYADRGLRETR 647
Cdd:PRK05729 494 MGLHFTGQV----P-FKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYR 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 648 ---TKVFgtleNvysffAT-YA--NIDGFTADTPAPAvAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFI- 720
Cdd:PRK05729 569 nfaNKLW----N-----ASrFVlmNLEGADVGELPDP-EELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIw 638
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 721 DALSNWYIRRSRARFWAgaradaggdaseaevADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYgQLVNESGARASVHL 800
Cdd:PRK05729 639 NEFCDWYLELAKPVLQE---------------AAKRATRATLAYVLEQILRLLHPFMPFITEELW-QKLAPLGIEESIML 702
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 801 ADFPaADAALIDADLERRMALARAIVANALALRNEAGLNVRQPLArILVVEEADVARADVDAIAAIVRDEINVDAIEFVA 880
Cdd:PRK05729 703 APWP-EADEAIDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILA 780
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
19-882 |
9.20e-54 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 202.97 E-value: 9.20e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 19 IRRWWDQEEVFEAStaARADGPTFTFYEGPPTANGRpgIH--HVLGRTIKDTFCRYKTMCGYRV------DrkagwdtH- 89
Cdd:COG0525 16 WYQYWEENGYFKAD--PDSDKEPFTIVIPPPNVTGS--LHmgHALNNTLQDILIRYKRMQGYNTlwqpgtD-------Ha 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 90 GLPVEIEVEKEL---GlKSREDI-------------ENYG--IAEynaacresvlryktQWddltRRIGFWADLDAPYVT 151
Cdd:COG0525 85 GIATQAVVERQLaeeG-KSRHDLgrekflervwewkEESGgtITN--------------QL----RRLGASCDWSRERFT 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 152 FSNEYIESVWWLLKQLHEQGLLYKGHKI-HWySPGSGTVLSSHEVSlgYKEVQDPSITVKFFLEDEPDVAILAwTTTPWT 230
Cdd:COG0525 146 MDEGLSKAVREVFVRLYEKGLIYRGKRLvNW-DPKLKTALSDLEVE--HEEVKGHLWHIRYPLADGSGYIVVA-TTRPET 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 231 MPSNVALAVGPNIE-YAKaraedgsvYIVAKACVAATlgeNAEI---------LEtFGADAL------------IGKRYK 288
Cdd:COG0525 222 MLGDTAVAVHPEDErYKH--------LIGKTVILPLV---GREIpiiadeyvdPE-FGTGAVkitpahdpndfeVGKRHN 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 289 -PPYDCFadhpeadqawrviaadfitTDDGTgIAHEAPAFgaddfrvtsaEGMPVFnpiernghfqadfplvgglwfkDA 367
Cdd:COG0525 290 lPMINIL-------------------DEDGT-INENAGKY----------RGLDRF----------------------EA 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 368 DKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPlmnypVES-----WFVATQQNKDKLVAY--NDRINWFPAHvGTGRFG 440
Cdd:COG0525 318 RKAIVADLEELGLLVKVEPHKHSVGHSDRSGTV-----IEPylsdqWFVKMKPLAKPAIEAveDGEIKFVPER-WEKTYF 391
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 441 DWLENNVDWALSRHRFWGTPLPIWVNDNNpdEIVVIGSIAELREYAGDQ--VADDDTLDlhkpqvdaitwtaedggTmrr 518
Cdd:COG0525 392 HWMENIRDWCISRQLWWGHRIPAWYCPDG--EVYVARTEPEACAKAGSVnlTQDEDVLD-----------------T--- 449
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 519 vpeiidvWFDSGAMPFAQWHYPFENQE--RFeanFPAD----------FicegvdqtrgW-----FYSLHAIGtlikDSP 581
Cdd:COG0525 450 -------WFSSALWPFSTLGWPEKTEDlkYF---YPTSvlvtgfdiifF----------WvarmiMMGLHFTG----EVP 505
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 582 aYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYAdrglrETRtkvfgtLENvYSFF 661
Cdd:COG0525 506 -FKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFD-----EER------VEG-YRNF 572
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 662 AT-------YA--NIDGFTADTPAPAVAERPElDRWILSRLQSTAAEASAALDEYNPTRAARAVERFI-DALSNWYIRRS 731
Cdd:COG0525 573 ANklwnasrFVlmNLEGFDPGLDPDPEELSLA-DRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYLELA 651
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 732 RARFWagaradaGGDAseaevADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYgQLVNESGARASVHLADFPAADAALI 811
Cdd:COG0525 652 KPRLY-------GGDE-----AAKRETRATLVYVLEQILRLLHPFMPFITEEIW-QKLPPRKEGESIMLAPWPEADEELI 718
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493970654 812 DADLERRMALARAIVANALALRNEAGLNVRQPLArILVVEEADVARADVDAIAAIVRDEINVDAIEFVAGE 882
Cdd:COG0525 719 DEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
404-636 |
2.52e-47 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 171.83 E-value: 2.52e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 404 YPVESWFVATQQNKDKLVAYNDRINWFPAHVGTgRFGDWLENNVDWALSRHRFWGTPLPIWVndnnpdeivvigsiaelr 483
Cdd:cd00668 137 RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAISRQRYWGTPLPEDV------------------ 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 484 eyagdqvadddtldlhkpqvdaitwtaedggtmrrvpeiIDVWFDSGAMPFAQWHYPFENQErFEANFPADFICEGVDQT 563
Cdd:cd00668 198 ---------------------------------------FDVWFDSGIGPLGSLGYPEEKEW-FKDSYPADWHLIGKDIL 237
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493970654 564 RGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNT 636
Cdd:cd00668 238 RGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDI 310
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
21-804 |
3.24e-44 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 174.04 E-value: 3.24e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 21 RWWDQEEVFEASTAARAD--GPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVE 98
Cdd:PTZ00419 39 EWWEKSGFFKPAEDAKSLnsGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 99 KEL---GLKSREDienYGiaeynaacRESVLRYKTQWDDL--------TRRIGFWADLDAPYVTFSNEYIESVWWLLKQL 167
Cdd:PTZ00419 119 KKLmkeENKTRHD---LG--------REEFLKKVWEWKDKhgnnicnqLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 168 HEQGLLYKGHKIHWYSPGSGTVLSSHEVSlgYKEVQDPS-ITV-------------KFF--LEDEPDVAILAWTTTPWTM 231
Cdd:PTZ00419 188 YEDGLIYRDTRLVNWCCYLKTAISDIEVE--FEEIEKPTkITIpgydkkvevgvlwHFAypLEDSGQEEIVVATTRIETM 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 232 PSNVALAVGPNIE-YAKaraedgsvyivakacvaatlgenaeiletfgadaLIGKRYKPPYDCfadhpeaDQAWRVIAAD 310
Cdd:PTZ00419 266 LGDVAVAVHPKDErYKK----------------------------------LHGKELIHPFIP-------DRKIPIIADD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 311 -FITTDDGTGIAHEAPAFGADDFRVTSAEGMPVFNPIERNGHFQADFPLVGGLWFKDADKPVARDLKDRGLLfsQQVTVH 389
Cdd:PTZ00419 305 eLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLL--RDKVPN 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 390 NY--PHDWRKG--TPLMNYPveSWFVATQ----------QNKD-KLVAYNDRINWFpahvgtgrfgDWLENNVDWALSRH 454
Cdd:PTZ00419 383 PMrlPRCSRSGdiVEPMLIP--QWYVNCKdmakraveavRNGElKIIPSSHENVWY----------HWLENIQDWCISRQ 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 455 RFWGTPLPIW-------VNDNNPDEIVVIG-SIAELREYAGDQVADddtldlhkpqvdaitwtAEDGGTMRRVPEIIDVW 526
Cdd:PTZ00419 451 LWWGHRIPAYrviskgpETDPSDEEPWVVArSEEEALEKAKKKFGL-----------------SEEDFELEQDEDVLDTW 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 527 FDSGAMPFAQWHYPFENQErFEANFPADFICEGVDQTRGW-----FYSLHAIGTLikdsPaYKNVVVNGLLLDANGEKMS 601
Cdd:PTZ00419 514 FSSGLFPFSTLGWPDQTDD-LQRFFPTSLLETGSDILFFWvarmvMMSLHLTDKL----P-FKTVFLHAMVRDSQGEKMS 587
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 602 KSKGNTVDPFEALD-------------------------------------EHGADVIRWYMLA--NSPP---------- 632
Cdd:PTZ00419 588 KSKGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLAytQQGRninldinrvv 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 633 ---------WDNTKYAdrglretrtkvFGTLENVYSffatYANIDGFTADTpapaVAERPELDRWILSRLQSTAAEASAA 703
Cdd:PTZ00419 668 gyrhfcnklWNAVKFA-----------LMKLLKDFN----LPNSTLFKPNN----VESLPWEDKWILHRLNVAIKEVTEG 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 704 LDEYNPTRAARAVERF-IDALSNWYIRRSRARFwagaradaggdASEAEVADKRAAYHTTLTCLRDVAAMMAPIAPFFAD 782
Cdd:PTZ00419 729 FKEYDFSEATQATYNFwLYELCDVYLELIKPRL-----------SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITE 797
|
890 900
....*....|....*....|..
gi 493970654 783 WLYGQLVNESGARASVHLADFP 804
Cdd:PTZ00419 798 ELYQRLPNYLRKSESISIAKYP 819
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
19-794 |
1.03e-42 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 169.35 E-value: 1.03e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 19 IRRWWDQEEVFEAsTAARADGPtFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVE 98
Cdd:PLN02943 69 IYNWWESQGYFKP-NFDRGGDP-FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 99 KEL---GLKsREDIenyGIAEYNAACRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYK 175
Cdd:PLN02943 147 KMLaseGIK-RTDL---GRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQ 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 176 GHKIHWYSPGSGTVLSSHEVSlgYKEVQDPSITVKFFLEDEPDVAILAWTTTPWTMPSNVALAVGPNIE-YAKaraedgs 254
Cdd:PLN02943 223 GSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPEDDrYSK------- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 255 vYIVAKACVAATLGenaeiletfgadaligkRYKPpydcfadhpeadqawrVIAADFITTDDGTGIAHEAPAFGADDFRV 334
Cdd:PLN02943 294 -YIGKMAIVPMTYG-----------------RHVP----------------IIADRYVDKDFGTGVLKISPGHDHNDYLL 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 335 TSAEGMPVFNPIERNGHFQAdfplVGGLWFKDADKPVARDLKDRGLLFSQQVTVHNYPHDWRKGTPLMNYPVESWFVATQ 414
Cdd:PLN02943 340 ARKLGLPILNVMNKDGTLNE----VAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTME 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 415 QNKDK--LVAYNDRINWFPAhvgtgRF----GDWLENNVDWALSRHRFWGTPLPIW--VNDNNPDEIVVIGSIAELREYA 486
Cdd:PLN02943 416 PLAEKalKAVENGELTIIPE-----RFekiyNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEEDYIVARSAEEALEKA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 487 GDQVADDdtLDLHKPqvdaitwtaedggtmrrvPEIIDVWFDSGAMPFAQWHYPFENQERFEANFPADFICEGVDQTRGW 566
Cdd:PLN02943 491 REKYGKD--VEIYQD------------------PDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGHDILFFW 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 567 FYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYADrglRET 646
Cdd:PLN02943 551 VARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTE---RLT 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 647 RTKVF-GTLENVYSFF----------ATYANIDGFTADTPApAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARA 715
Cdd:PLN02943 628 SNKAFtNKLWNAGKFVlqnlpsqsdtSAWEHILACKFDKEE-SLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGRE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 716 VERFI-DALSNWYIRRSRARFWagaradAGGDASEAEVADKRAAYhttltCLRDVAAMMAPIAPFFADWLYGQLVNESGA 794
Cdd:PLN02943 707 IYDFFwSDFADWYIEASKTRLY------HSGDNSALSRAQAVLLY-----VFENILKLLHPFMPFVTEELWQALPYRKEA 775
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
395-638 |
3.10e-39 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 150.47 E-value: 3.10e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 395 WRKGTPLMNYPVESWFVATQQNKDKL--VAYNDRINWFPAHVGTgRFGDWLENNVDWALSRHRFWGTPLPIWVNDNNPDE 472
Cdd:cd00817 157 SRSGDVIEPLLKPQWFVKVKDLAKKAleAVKEGDIKFVPERMEK-RYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHW 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 473 IVVigsiaelREyagDQVADDDTLDLHKPQVDAITWtaedggtmRRVPEIIDVWFDSGAMPFAQWHYPfENQERFEANFP 552
Cdd:cd00817 236 VVA-------RE---EDEAIDKAAPEACVPCGGEEL--------KQDEDVLDTWFSSSLWPFSTLGWP-EETKDLKKFYP 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 553 ADFICEGVDQTRGW-----FYSLHAIGTLikdsPaYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYML 627
Cdd:cd00817 297 TSLLVTGHDIIFFWvarmiMRGLKLTGKL----P-FKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLA 371
|
250
....*....|.
gi 493970654 628 ANSPPWDNTKY 638
Cdd:cd00817 372 SAATQGRDINL 382
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
41-178 |
2.79e-35 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 136.78 E-value: 2.79e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 41 TFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEKELGLKSREDIenygIAEYNAA 120
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 493970654 121 CRESVLRYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGHK 178
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTH 134
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
62-918 |
7.26e-29 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 124.98 E-value: 7.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 62 GRT--IKDTFCRYKTMCGYRVDRKAGWDTHGLPV-------------EIEVEKELGLKSREDIENYG----IAEYnaacr 122
Cdd:PRK12300 6 GRTytIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdpeTIELYKSLYGIPEEELEKFKdpeyIVEY----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 123 esvlrYKTQWDDLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKG-HKIHWySPGSGTVLSSHEVslgyKE 201
Cdd:PRK12300 81 -----FSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGsHPVRY-CPNDNNPVGDHDL----LD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 202 VQDPSI---TVKFFLEDEpDVAILAWTTTPWTMPSNVALAVGPNIEYAKARAeDGSVYIVAKACvAATL---GENAEILE 275
Cdd:PRK12300 151 GEEPEIveyTLIKFEESE-DLILPAATLRPETIFGVTNLWVNPDATYVKAEV-DGEKWIVSKEA-AEKLsfqDRDVEIIE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 276 TFGADALIGKRYKPPYdCFADHPeadqawrVIAADFITTDDGTGI-----AHeAPA------------------------ 326
Cdd:PRK12300 228 EIKGSELIGKKVKNPV-TGKEVP-------ILPADFVDPDNGTGVvmsvpAH-APYdyvalrdlkknkelldviepipli 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 327 --FGADDFRVTSA-EGMPVFNPIER---------------NGHFQADFPLVGGLWFKDADKPVARDLKDRGLL-----FS 383
Cdd:PRK12300 299 evEGYGEFPAKEVvEKLGIKSQEDPeleeatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIAdimyeFS 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 384 qqvtvhNYPHDWRKGTP----------LMNYPVESWfvatqqnKDKLVAYNDRINWFPAHVgtgR--FG---DWLEnnvD 448
Cdd:PRK12300 379 ------NRPVYCRCGTEcvvkvvkdqwFIDYSDPEW-------KELAHKALDNMEIIPEEY---RkeFEntiDWLK---D 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 449 WALSRHRFWGTPLPiWvndnnpDEIVVIGS------------IAE-LREY--AGDQVADD--DTLDLHKPQVDAItwtAE 511
Cdd:PRK12300 440 RACARRRGLGTRLP-W------DEEWIIESlsdstiymayytIAHkIREYgiKPEQLTPEffDYVFLGKGDPEEV---SK 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 512 DGGTMrrvPEIIDvwfdsgampfaqwhypfENQERFEANFPADFICEGVD--QTRGWFYSLHAIGTLIKDS-PayKNVVV 588
Cdd:PRK12300 510 KTGIP---KEILE-----------------EMREEFLYWYPVDWRHSGKDliPNHLTFFIFNHVAIFPEEKwP--RGIVV 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 589 NGLLLdANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYADRGLRETRtkvfGTLENVYSFFATYANID 668
Cdd:PRK12300 568 NGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVR----RQLERFYELAKELIEIG 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 669 GFTADTPapavaerpeLDRWILSRLQSTAAEASAALDEYNpTRAArAVERFIDALS--NWYIRRsrarfwagaradaGGD 746
Cdd:PRK12300 643 GEEELRF---------IDKWLLSRLNRIIKETTEAMESFQ-TRDA-VQEAFYELLNdlRWYLRR-------------VGE 698
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 747 ASEAEVAdkraayhttlTCLRDVAAMMAPIAPFFADWLYGQLVNESgaraSVHLADFPAADAALIDADLERRMALARAIV 826
Cdd:PRK12300 699 ANNKVLR----------EVLEIWIRLLAPFTPHLAEELWHKLGGEG----FVSLEKWPEPDESKIDEEAELAEEYVKRLI 764
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 827 ANALALRNEAGLNVRqplaRILVVeeadVARADVDAIAAIVRDEINVdaiefvageGDLVKR-SAKPNFKTLGKRLGKKM 905
Cdd:PRK12300 765 EDIREILKVAKIKPK----KVYIY----VAPDWKYEVLEIAAENGDV---------KEAIKElMKDEELRKHGKEVAKLA 827
|
970
....*....|...
gi 493970654 906 KAVAGAVAALDDE 918
Cdd:PRK12300 828 QKIVKEVLKLDKE 840
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
22-835 |
7.58e-29 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 125.01 E-value: 7.58e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 22 WWDQEEVFEAStaARADGPTFTFYEGPPTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEKEL 101
Cdd:PLN02381 112 WWEKSGYFGAD--AKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 102 GLK---SREDI--ENYgIAEynaacresVLRYKTQWD----DLTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGL 172
Cdd:PLN02381 190 MRErhlTRHDIgrEEF-VSE--------VWKWKDEYGgtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 173 LYKGHK-IHWYSPGSgTVLSSHEVSL------------GYKEVQDPSITVKFFLEDEPDVA-ILAWTTTPWTMPSNVALA 238
Cdd:PLN02381 261 IYRDIRlVNWDCTLR-TAISDVEVDYidikertllkvpGYDKPVEFGVLTSFAYPLEGGLGeIVVATTRIETMLGDTAIA 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 239 VGPnieyakaraEDGsvyivakacvaatlgenaeiletfgadaligkRYKPPYDCFADHPEADQAWRVIA-ADFITTDDG 317
Cdd:PLN02381 340 IHP---------DDE--------------------------------RYKHLHGKFAVHPFNGRKLPIICdAILVDPNFG 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 318 TGIAHEAPAFGADDFRVTSAEGMPVFNPIERNGHFQADfplvGGLWFKDADKPVARD-----LKDRGLLFSQQvtvhnyP 392
Cdd:PLN02381 379 TGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSN----GGSEFAGMPRFAAREavieaLQKKGLYRGAK------N 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 393 HDWRKG-TPLMNYPVE-----SWFV-----ATQQNKDKLVAYNDRINWFPAHVgTGRFGDWLENNVDWALSRHRFWGTPL 461
Cdd:PLN02381 449 NEMRLGlCSRTNDVVEpmikpQWFVncssmAKQALDAAIDGENKKLEFIPKQY-LAEWKRWLENIRDWCISRQLWWGHRI 527
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 462 PIWVNDNNPDEIVVIGSiaelreYAGDQVADDDTLDLHKPQVDAITWTAEDggtMRRVPEIIDVWFDSGAMPFAQWHYPf 541
Cdd:PLN02381 528 PAWYVTLEDDQLKELGS------YNDHWVVARNESDALLEASQKFPGKKFE---LSQDPDVLDTWFSSGLFPLSVLGWP- 597
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 542 ENQERFEANFPADFICEGVDQTRGWFYSLHAIGTLIKDSPAYKNVVVNGLLLDANGEKMSKSKGNTVDPFEALD------ 615
Cdd:PLN02381 598 DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleg 677
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 616 -------------------------------EHGADVIRWYMLANSPPWDNTKYADR---GLRETRTKVFGTLEnvysfF 661
Cdd:PLN02381 678 lhkrleegnldpkelvvakegqkkdfpngiaECGTDALRFALVSYTAQSDKINLDILrvvGYRQWCNKLWNAVR-----F 752
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 662 ATYANIDGFTADTPAPaVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAV---------ERFIDALSNWYIrrsr 732
Cdd:PLN02381 753 AMSKLGDDYTPPATLS-VETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVyswwqyqfcDVFIEAIKPYFA---- 827
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 733 arfwagaradagGDASEAEvADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL--VNESGARASVHLADFPAADAAL 810
Cdd:PLN02381 828 ------------GDNPEFA-SERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLpqPKDHTRKDSIMISEYPSAVEAW 894
|
890 900
....*....|....*....|....*
gi 493970654 811 IDADLERRMALARAIVANALALRNE 835
Cdd:PLN02381 895 TNEKVEYEMDLVLSTVKCLRSLRAE 919
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
686-848 |
3.46e-25 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 102.10 E-value: 3.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 686 DRWILSRLQSTAAEASAALDEYNPTRAARAVERFI-DALSNWYIRRSRARFWAGARADaggdaseaevadkrAAYHTTLT 764
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS--------------RAQTTLYE 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 765 CLRDVAAMMAPIAPFFADWLYgqlvnesgARASVHLADFPaADAALIDADLERRMALARAIVANALALRNEAGLNVRQPL 844
Cdd:pfam08264 67 VLETLLRLLAPFMPFITEELW--------QKESIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPL 137
|
....
gi 493970654 845 ARIL 848
Cdd:pfam08264 138 EVVI 141
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
373-635 |
3.39e-19 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 89.61 E-value: 3.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 373 RDLKDRGLLFSQQVTVhnyphDWRKGTP--LMNYPVESWfvatqqnKDKLVAYNDRINWFPAHVGTGrFGDWLEnnvdwa 450
Cdd:cd00812 108 LKLYEKGLAYKKEAPV-----NWCKLLDqwFLKYSETEW-------KEKLLKDLEKLDGWPEEVRAM-QENWIG------ 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 451 LSRHRFWGTPLPI-WVNDNNPDEivvigSIAELReYagdqvadddtLDLHKPQVDAITWTAEDggtmrrvpeiidvwfds 529
Cdd:cd00812 169 CSRQRYWGTPIPWtDTMESLSDS-----TWYYAR-Y----------TDAHNLEQPYEGDLEFD----------------- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 530 gampfaqwhypfenQERFEANFPADFICEGVDQT-------RGWFYSLHAIGTLIKDSPayKNVVVNGLLLdANGEKMSK 602
Cdd:cd00812 216 --------------REEFEYWYPVDIYIGGKEHApnhllysRFNHKALFDEGLVTDEPP--KGLIVQGMVL-LEGEKMSK 278
|
250 260 270
....*....|....*....|....*....|...
gi 493970654 603 SKGNTVDPFEALDEHGADVIRWYMLANSPPWDN 635
Cdd:cd00812 279 SKGNVVTPDEAIKKYGADAARLYILFAAPPDAD 311
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
666-788 |
8.85e-19 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 83.76 E-value: 8.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 666 NIDGFTADTPAPAVAErpELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFI-DALSNWYIRRSRARFWagaradaG 744
Cdd:cd07962 26 NLEDDDEPEEDPESLS--LADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYLELVKPRLY-------G 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 493970654 745 GDASEaevadKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL 788
Cdd:cd07962 97 EDEEE-----KKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
581-788 |
3.62e-18 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 89.40 E-value: 3.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 581 PAYKNVVVNGLLLdANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPpwdNTKYADRGLRETRTKVFGTLENVYSF 660
Cdd:COG0143 310 PLPKKVFAHGFLT-VEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVP---FGQDGDFSWEDFVARVNSDLANDLGN 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 661 FA------TYANIDGFTadtpaPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALsNWYIrrSRAR 734
Cdd:COG0143 386 LAsrtlsmIHKYFDGKV-----PEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALARAA-NKYI--DETA 457
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 493970654 735 FWAGARadaggDASEAEVAdkrAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL 788
Cdd:COG0143 458 PWKLAK-----DEDPERLA---TVLYTLLEALRILAILLKPFLPETAEKILEQL 503
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
20-792 |
3.92e-17 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 86.80 E-value: 3.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 20 RRWWDQEEVFEASTAARADGPTFTFYEGPPTANGrPGIH--HVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEiEV 97
Cdd:PLN02563 90 QRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSG-AGLHvgHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAE-QY 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 98 EKELGLKSREDIEnygiaeynaacrESVLRYKTQWDDLtrriGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGH 177
Cdd:PLN02563 168 AIETGTHPKITTL------------KNIARFRSQLKSL----GFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAE 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 178 KIHWYSPGSGTVLSSHEVSLGYKE------VQDP------SIT----------------------------------VKF 211
Cdd:PLN02563 232 VPVNWCPALGTVLANEEVVDGLSErgghpvIRKPmrqwmlKITayadrlledlddldwpesikemqrnwigrsegaeLDF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 212 FLED----EPDVAILAWTTTPWTMPSNVALAVGPNIEYAKARAEDGSVYIVAKACVAATLGENAEILETfgadaligKRY 287
Cdd:PLN02563 312 SVLDgegkERDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTEL--------QKE 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 288 KPPYD--CFADHPEADQAWRVIAADFITTDDGTGIAHEAPAFGADDFRVTSAEGMPVFNPIErnghfqadfPLVGGLWfk 365
Cdd:PLN02563 384 KTGVFtgSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVK---------PADGNED-- 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 366 DADKPVARDLK-----DRGLLFSQQVTvhnypHDWRKGtplmnypVESWFVATQQNKDKlVAYNDRinwfpahvgtgrfg 440
Cdd:PLN02563 453 DAEKAYTGEGVivnssSSGLDINGLSS-----KEAAKK-------VIEWLEETGNGKKK-VNYKLR-------------- 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 441 dwlennvDWALSRHRFWGTPLPIWVNDNNpDEIVvigsiaelreyagdQVADDDtLDLHKPQVDAITWTAEDGGTMRRVP 520
Cdd:PLN02563 506 -------DWLFARQRYWGEPIPVVFLEDS-GEPV--------------PVPESD-LPLTLPELDDFTPTGTGEPPLAKAV 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 521 EIIDVWFDSGAMPFAQ------------WHY-----PFENQERFEAN-----FPADFICEGVDQ-------TRGWFYSLH 571
Cdd:PLN02563 563 SWVNTVDPSSGKPARRetntmpqwagscWYYlrfmdPKNSNALVDKEkekywMPVDLYVGGAEHavlhllyARFWHKVLY 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 572 AIGTLIKDSPaYKNVVVNGLLL---------DANGE-------------------------------------------- 598
Cdd:PLN02563 643 DIGVVSTKEP-FQCLVNQGMILgeveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliara 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 599 -KMSKSKGNTVDPFEALDEHGADVIRWYMLANSPpwdntkyadrgLRETRTKVFGTLENVYSFFA-TYANIDGFTAD--- 673
Cdd:PLN02563 722 hKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGP-----------LRDSKTWSTSGVEGVHRFLGrTWRLVVGAPLPdgs 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 674 TPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALSNWyirrsrarfwagaradaggdaseaeva 753
Cdd:PLN02563 791 FRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKW--------------------------- 843
|
890 900 910
....*....|....*....|....*....|....*....
gi 493970654 754 DKRAAyhttlTCLRDVAAMMAPIAPFFADWLYGQLVNES 792
Cdd:PLN02563 844 DKVPR-----EAIEPFVLLLSPYAPHLAEELWFRLGHSN 877
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
522-788 |
1.67e-16 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 83.78 E-value: 1.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 522 IIDVWFDSGAMPFAQWHYPFENQ---ERFEANFPAD--FIceGVDQTRgwfysLHAIGtlikdSPAY---------KNVV 587
Cdd:PRK11893 221 VIYVWFDALTNYLTALGYPDDEEllaELFNKYWPADvhLI--GKDILR-----FHAVY-----WPAFlmaaglplpKRVF 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 588 VNGLLLDaNGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYADRGLRETRTkvfGTLENVY------SFF 661
Cdd:PRK11893 289 AHGFLTL-DGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINRIN---ADLANDLgnlaqrTLS 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 662 ATYANIDGFTadtpaPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALsNWYIRRSRArfWAGARA 741
Cdd:PRK11893 365 MIAKNFDGKV-----PEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAA-NKYIDEQAP--WSLAKT 436
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 493970654 742 DaggdasEAEVADkraAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL 788
Cdd:PRK11893 437 D------PERLAT---VLYTLLEVLRGIAVLLQPVMPELAAKILDQL 474
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
665-825 |
1.73e-15 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 75.64 E-value: 1.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 665 ANIDGFTADTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFI-DALSNWYIrrsrarfwagaraDA 743
Cdd:cd07960 25 GNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYL-------------DI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 744 GGDA--SEAEVADKRAAYHTTL-TCLRDVAAMMAPIAPFFAD--WLYgqlVNESGARASVHLADFPAADAALIDADLERR 818
Cdd:cd07960 92 IKDRlyCDAKDSLERRSAQTVLyHILDALLKLLAPILPFTAEevWEH---LPGEKKEESVFLEDWPELPEEWKDEELEEK 168
|
....*..
gi 493970654 819 MALARAI 825
Cdd:cd07960 169 WEKLLAL 175
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
525-788 |
6.86e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 75.99 E-value: 6.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 525 VWFDS--------GampfaqwhYPFENQERFEANFPADFICEGVDQTRgwFYS------LHAIGTlikdsPAYKNVVVNG 590
Cdd:PRK12267 227 VWIDAllnyitalG--------YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMALGL-----PLPKKVFAHG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 591 LLLdANGEKMSKSKGNTVDPFEALDEHGADVIRWYMlansppwdntkyadrgLRETrtkVFGtLENVYSFFATyanIDGF 670
Cdd:PRK12267 292 WWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYL----------------LREV---PFG-SDGDFSPEAL---VERI 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 671 TAD-----------TPA----------PAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALsNWYIR 729
Cdd:PRK12267 348 NSDlandlgnllnrTVAminkyfdgeiPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLISRA-NKYID 426
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 493970654 730 RSRArfWAGARadaggDASEAEVADkrAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL 788
Cdd:PRK12267 427 ETAP--WVLAK-----DEGKKERLA--TVMYHLAESLRKVAVLLSPFMPETSKKIFEQL 476
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
598-804 |
1.33e-13 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 75.47 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 598 EKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPP-----WDntkyaDRGL----RetrtkvFgtLENVYSFFATYanid 668
Cdd:COG0495 588 EKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPerdleWS-----DSGVegayR------F--LNRVWRLVVDE---- 650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 669 gftADTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRA-ARAVErFIDALSNWyirrsrarfwagaradagGDA 747
Cdd:COG0495 651 ---AEALKLDVADLSEADKELRRALHKTIKKVTEDIERLRFNTAiAALME-LVNALYKA------------------KDS 708
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 493970654 748 SEAEVADKRAAyhttltcLRDVAAMMAPIAPFFADWLYGQLvnesGARASVHLADFP 804
Cdd:COG0495 709 GEADRAVLREA-------LETLVLLLAPFAPHIAEELWERL----GHEGSVADAPWP 754
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
505-632 |
1.56e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 69.87 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 505 AITWTAEDGGTmrRVPE----IIDVWFD------SGAmpfAQWHYPFENQERFEANFPAD--FIceGVDQTRgwFYS--- 569
Cdd:cd00814 183 SITRDLFDWGI--PVPLdpgkVIYVWFDaligyiSAT---GYYNEEWGNSWWWKDGWPELvhFI--GKDIIR--FHAiyw 253
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493970654 570 ---LHAIGTlikdsPAYKNVVVNGLLLdANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPP 632
Cdd:cd00814 254 pamLLGAGL-----PLPTRIVAHGYLT-VEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPE 313
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
640-777 |
2.96e-11 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 61.37 E-value: 2.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 640 DRGLRETRtKVFGTLENVYSFFATYANIDgftadTPAPAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERF 719
Cdd:cd07375 1 EERLKQAR-AFLNRLYRLLSFFRKALGGT-----QPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKF 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 493970654 720 IDALsNWYIRRSRARFWAGaradaggdaseaevADKRAAYHTTLTCLRDVAAMMAPIA 777
Cdd:cd07375 75 TNEL-NWYLDELKPALQTE--------------ELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
49-195 |
2.10e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 63.85 E-value: 2.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 49 PTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEKElGLKSREDIENygiaeYNAACRESVLRY 128
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKE-GITPEELVDR-----YHEIHREDFKKF 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493970654 129 KTQWDDLTRrigfwadldapyvTFSNEYIESVWWLLKQLHEQGLLYKGHKIHWYSPGSGTVLSSHEV 195
Cdd:pfam09334 82 NISFDDYGR-------------TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYV 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
49-181 |
6.26e-10 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 61.88 E-value: 6.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 49 PTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEievekELGLKSREDIENygIAEYNAAcresvlRY 128
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE-----NAAIKIGRDPED--WTEYNIK------KM 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 493970654 129 KTQwddlTRRIGFWADLDAPYVTFSNEYIESVWWLLKQLHEQGLLYKG-HKIHW 181
Cdd:cd00812 76 KEQ----LKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKeAPVNW 125
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
49-191 |
3.76e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.47 E-value: 3.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 49 PTANGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEIEVEKElGLKSREDIENYgiaeynaacresVLRY 128
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE-GVTPQELCDKY------------HEIF 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493970654 129 KTQWDDLtrRIGFwadlDAPYVTFSNEYIESVWWLLKQLHEQGLLYKGHKIHWYSPGSGTVLS 191
Cdd:cd00814 76 KDLFKWL--NISF----DYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP 132
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
525-646 |
4.06e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 60.00 E-value: 4.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 525 VWFDS--GAMPFAQwhYPFENQERFEANFPADFICE-----GVDQTRgwFYSLHAIGTLI-KDSPAYKNVVVNGLLLdAN 596
Cdd:pfam09334 247 VWLDApiGYISATK--ELSGNEEKWKEWWPNDPDTElvhfiGKDIIY--FHTIFWPAMLLgAGYRLPTTVFAHGYLT-YE 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 493970654 597 GEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPWDNTKYADRGLRET 646
Cdd:pfam09334 322 GGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWEDFVER 371
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
505-631 |
5.89e-09 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 59.70 E-value: 5.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 505 AITWTAEDGGTmrRVPE----IIDVWFDS--GAMPFAQwhYPFENQERFEANFPAD-------FIceGVDQTRgwFYSLH 571
Cdd:TIGR00398 228 AITRDLVYWGI--PVPNdpnkVVYVWFDAliGYISSLG--ILSGDTEDWKKWWNNDedaelihFI--GKDIVR--FHTIY 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493970654 572 AIGTLIK-DSPAYKNVVVNGLLLDaNGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSP 631
Cdd:TIGR00398 300 WPAMLMGlGLPLPTQVFSHGYLTV-EGGKMSKSLGNVVDPSDLLARFGADILRYYLLKERP 359
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
585-788 |
1.90e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 58.62 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 585 NVVVNGLLlDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPPwdNTKYADRGLRETRTKVFGTLENVYSFFA-- 662
Cdd:PRK00133 316 NVFAHGFL-TVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPE--TIDDLDFNWEDFQQRVNSELVGKVVNFAsr 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 663 ----TYANIDGFTADTpapavaerpELDRWILSRLQSTAAEASAALDEYNPTRAARAverfIDALS---NWYIRRSRArf 735
Cdd:PRK00133 393 tagfINKRFDGKLPDA---------LADPELLEEFEAAAEKIAEAYEAREFRKALRE----IMALAdfaNKYVDDNEP-- 457
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 493970654 736 WAGARADAggdaseaevADKRAAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL 788
Cdd:PRK00133 458 WKLAKQDG---------ERLQAVCSVGLNLFRALAIYLKPVLPELAERAEAFL 501
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
589-723 |
2.12e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 57.80 E-value: 2.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 589 NGLLLDaNGEKMSKSKGNTVDPFEALDEHGADVIRWYMLAN---SPpwdnTKYADRGLRETRTkvfgTLENVYSFfatYA 665
Cdd:COG0215 256 NGFLTV-NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyrSP----LDFSEEALEEAEK----ALERLYNA---LR 323
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 666 NIDGFTADTPAPAVAERPELDRWI------------LSRLQSTAAEASAALDEYNPTRAARAVERFIDAL 723
Cdd:COG0215 324 RLEEALGAADSSAEEIEELREEFIaamdddfntpeaLAVLFELVREINKALDEGEDKAALAALAALLRAL 393
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
589-627 |
2.77e-06 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 49.50 E-value: 2.77e-06
10 20 30
....*....|....*....|....*....|....*....
gi 493970654 589 NGLLLdANGEKMSKSKGNTVDPFEALDEHGADVIRWYML 627
Cdd:cd00672 165 TGHLT-IDGEKMSKSLGNFITVRDALKKYDPEVLRLALL 202
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
596-732 |
5.38e-06 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 50.41 E-value: 5.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 596 NGEKMSKSKGN--TVDpfEALDEHGADVIRWYMLANspPWDNT-KYADRGLRETRTKvfgtlENVY-SFFatyANIDGFT 671
Cdd:PTZ00399 312 KGLKMSKSLKNfiTIR--QALSKYTARQIRLLFLLH--KWDKPmNYSDESMDEAIEK-----DKVFfNFF---ANVKIKL 379
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493970654 672 ADTPAPAVAERPELDRWILSRLQSTAAEASAAL-DEYNPTRAARAVERFIDALsNWYIRRSR 732
Cdd:PTZ00399 380 RESELTSPQKWTQHDFELNELFEETKSAVHAALlDNFDTPEALQALQKLISAT-NTYLNSGE 440
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
565-788 |
1.59e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 45.86 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 565 GWFYSLHAIGtliKDSPAYKNVVVNGLLLDA----------------NGEKMSKSKGNTVDPFEALDEHGADVIRWYMLA 628
Cdd:PLN02224 319 GWPASLHLIG---KDILRFHAVYWPAMLMSAglelpkmvfghgfltkDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFLR 395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 629 NSPPWDNTKYA-DRGLRETRTKVFGTLENVYSFF--------ATYANIDGFTADTPAP---AVAERPELDRWILSRLQ-S 695
Cdd:PLN02224 396 EVEFGNDGDYSeDRFIKIVNAHLANTIGNLLNRTlgllkkncESTLVEDSTVAAEGVPlkdTVEKLVEKAQTNYENLSlS 475
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 696 TAAEASAALdeynptraARAVERFIDALSNWYIRRSrarfwagaradaGGDASEAEVADkraaYHTTLTCLRDVAAMMAP 775
Cdd:PLN02224 476 SACEAVLEI--------GNAGNTYMDQRAPWFLFKQ------------GGVSAEEAAKD----LVIILEVMRVIAVALSP 531
|
250
....*....|...
gi 493970654 776 IAPFFADWLYGQL 788
Cdd:PLN02224 532 IAPCLSLRIYSQL 544
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
654-788 |
2.44e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 41.81 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 654 LENVYSFFA-TYANIDGFTADTPApavaerpelDRWILSRLQSTAAEASAALDEYNpTRAA--RAVERFIDALsNWYIRR 730
Cdd:cd07959 13 LERFYELAEeLIETEGELEELTFI---------DRWLLSRLNRLIKETTEAYENMQ-FREAlkEGLYELQNDL-DWYRER 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 493970654 731 SRARfwagaradAGGDASeAEVADKRaayhttltclrdvAAMMAPIAPFFADWLYGQL 788
Cdd:cd07959 82 GGAG--------MNKDLL-RRFIEVW-------------TRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
677-788 |
2.91e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 41.71 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 677 PAVAERPELDRWILSRLQSTAAEASAALDEYNPTRAARAVERFIDALsNWYIrrSRARFWAGARadaggDASEAEVAdkr 756
Cdd:cd07957 29 PEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARAA-NKYI--DETAPWKLAK-----EEDPERLA--- 97
|
90 100 110
....*....|....*....|....*....|..
gi 493970654 757 AAYHTTLTCLRDVAAMMAPIAPFFADWLYGQL 788
Cdd:cd07957 98 TVLYVLLELLRILAILLSPFMPETAEKILDQL 129
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
591-629 |
6.95e-04 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 43.65 E-value: 6.95e-04
10 20 30
....*....|....*....|....*....|....*....
gi 493970654 591 LLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLAN 629
Cdd:COG1384 279 LFLDENGEKISKSKGNGLTVEEWLEYAEPESLRYFMFRK 317
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
52-183 |
1.06e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 42.87 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493970654 52 NGRPGIHHVLGRTIKDTFCRYKTMCGYRVDRKAGWDTHGLPVEiEVEKELGLKSREdienY--GIAEynaacresvlRYK 129
Cdd:PRK12267 16 NGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQ-QAAEKAGKTPQE----YvdEISA----------GFK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 493970654 130 TQWDdltrrigfwaDLDAPYVTF----SNEYIESVWWLLKQLHEQGLLYKGHKIHWYS 183
Cdd:PRK12267 81 ELWK----------KLDISYDKFirttDERHKKVVQKIFEKLYEQGDIYKGEYEGWYC 128
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
591-631 |
4.86e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 40.32 E-value: 4.86e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 493970654 591 LLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSP 631
Cdd:pfam01921 271 LILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRTKP 311
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
591-632 |
6.94e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 40.18 E-value: 6.94e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 493970654 591 LLLDANGEKMSKSKGNTVDPFEALDEHGADVIRWYMLANSPP 632
Cdd:PRK00750 272 LFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLFMFARPKP 313
|
|
| |
