NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|493977738|ref|WP_006920743|]
View 

MULTISPECIES: CPBP family intramembrane glutamic endopeptidase [Bacillus]

Protein Classification

CPBP family intramembrane glutamic endopeptidase( domain architecture ID 11441430)

CPBP (CAAX proteases and bacteriocin-processing enzymes) family intramembrane protease similar to Saccharomyces cerevisiae Rce1, a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease that belongs to the glutamate IMPs, sharing a conserved sequence motif EExxxR

EC:  3.4.-.-
Gene Ontology:  GO:0004222|GO:0016020|GO:0070007|GO:0071586
PubMed:  24291792

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 131-220 2.09e-22

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 87.92  E-value: 2.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738 131 PWFLIVVSIIGPILEEIVFRKILFGTLYKKFNFFIAAIISSLVFAAIHFD-FTHLLVYTAMGLVFAFLYVKTKRIIVPIA 209
Cdd:COG1266    5 LLFLLVVVILAPIAEELLFRGYLLGRLRRRFGPWLAILLSSLLFGLLHLPnLLGFLPAFLLGLVLGLLYLRTGSLWVPIL 84

                         90
                 ....*....|.
gi 493977738 210 AHVAMNTLVAI 220
Cdd:COG1266   85 LHALNNLLALL 95
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 131-220 2.09e-22

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 87.92  E-value: 2.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738 131 PWFLIVVSIIGPILEEIVFRKILFGTLYKKFNFFIAAIISSLVFAAIHFD-FTHLLVYTAMGLVFAFLYVKTKRIIVPIA 209
Cdd:COG1266    5 LLFLLVVVILAPIAEELLFRGYLLGRLRRRFGPWLAILLSSLLFGLLHLPnLLGFLPAFLLGLVLGLLYLRTGSLWVPIL 84

                         90
                 ....*....|.
gi 493977738 210 AHVAMNTLVAI 220
Cdd:COG1266   85 LHALNNLLALL 95
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 132-217 9.19e-18

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 75.67  E-value: 9.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738  132 WFLIVVSIIGPILEEIVFRKILFGTLYKKFNFFIAAIISSLVFAAIHF--DFTHLLVYTAMGLVFAFLYVKTKRIIVPIA 209
Cdd:pfam02517   5 LLLLLLALLAPIGEELLFRGYLLPRLRRRLWPVLAILISSLLFGLAHLpnGPQLFLLAFLLGLILGYLYLRTGSLWAAIL 84


                  ....*...
gi 493977738  210 AHVAMNTL 217
Cdd:pfam02517  85 LHALNNLL 92
JDVT-CAAX NF033192
JDVT-CTERM system glutamic-type intramembrane protease; See NF033191.
 132-215 5.47e-07

JDVT-CTERM system glutamic-type intramembrane protease; See NF033191.


Pssm-ID: 467988 [Multi-domain]  Cd Length: 98  Bit Score: 46.56  E-value: 5.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738 132 WFLIVvsIIGPILEEIVFRKILFGTLYKKFNFF-------IAAIISSLVFAAIHF----DFTHLLVYtAMGLVFAFLYVK 200
Cdd:NF033192   1 LLSLV--LLQPLLEEWVFRGGLQEWLLRRTWGRarlggisLANLLTSAAFALAHLvahpWLWALAVF-VPSLLFGLFYER 77

                         90
                 ....*....|....*
gi 493977738 201 TKRIIVPIAAHVAMN 215
Cdd:NF033192  78 SRSLGPCIALHAFYN 92
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 131-220 2.09e-22

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 87.92  E-value: 2.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738 131 PWFLIVVSIIGPILEEIVFRKILFGTLYKKFNFFIAAIISSLVFAAIHFD-FTHLLVYTAMGLVFAFLYVKTKRIIVPIA 209
Cdd:COG1266    5 LLFLLVVVILAPIAEELLFRGYLLGRLRRRFGPWLAILLSSLLFGLLHLPnLLGFLPAFLLGLVLGLLYLRTGSLWVPIL 84

                         90
                 ....*....|.
gi 493977738 210 AHVAMNTLVAI 220
Cdd:COG1266   85 LHALNNLLALL 95
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 132-217 9.19e-18

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 75.67  E-value: 9.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738  132 WFLIVVSIIGPILEEIVFRKILFGTLYKKFNFFIAAIISSLVFAAIHF--DFTHLLVYTAMGLVFAFLYVKTKRIIVPIA 209
Cdd:pfam02517   5 LLLLLLALLAPIGEELLFRGYLLPRLRRRLWPVLAILISSLLFGLAHLpnGPQLFLLAFLLGLILGYLYLRTGSLWAAIL 84


                  ....*...
gi 493977738  210 AHVAMNTL 217
Cdd:pfam02517  85 LHALNNLL 92
JDVT-CAAX NF033192
JDVT-CTERM system glutamic-type intramembrane protease; See NF033191.
 132-215 5.47e-07

JDVT-CTERM system glutamic-type intramembrane protease; See NF033191.


Pssm-ID: 467988 [Multi-domain]  Cd Length: 98  Bit Score: 46.56  E-value: 5.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493977738 132 WFLIVvsIIGPILEEIVFRKILFGTLYKKFNFF-------IAAIISSLVFAAIHF----DFTHLLVYtAMGLVFAFLYVK 200
Cdd:NF033192   1 LLSLV--LLQPLLEEWVFRGGLQEWLLRRTWGRarlggisLANLLTSAAFALAHLvahpWLWALAVF-VPSLLFGLFYER 77

                         90
                 ....*....|....*
gi 493977738 201 TKRIIVPIAAHVAMN 215
Cdd:NF033192  78 SRSLGPCIALHAFYN 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH