|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
9-908 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1421.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 9 YPYDQIEPKWQERWESARTFHAPNpgdpgfDPARPKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPM 88
Cdd:COG0495 5 YNPKEIEKKWQKYWEENGTFKADE------DSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPM 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 89 GWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLRLYHsyfdpflqksrp 168
Cdd:COG0495 78 GWDAFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYE------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 169 islledaladepkrtdewkdddylaglrahsgdlpperrravreaiidhHRLAYVSEAPVNWCPALGTVLANEEVIDGKS 248
Cdd:COG0495 146 -------------------------------------------------KGLAYRKEAPVNWCPVDQTVLANEQVIDGRC 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 249 EVGGHPVERRPMRQWMLRITTYAQRLIDELDGLD-WPESIKLLQRNWIGRSEGAEVQFTVAGSEEKITVFTTRPDTLYGA 327
Cdd:COG0495 177 WRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDEKITVFTTRPDTLFGA 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 328 TYMVLAPEHPLVERIVTEEQAGAVEEYKEKTARKSDLERTELSKEKTGVWTGAFAINPVNVERIPIWIADYVLLGYGTGA 407
Cdd:COG0495 257 TFMVLAPEHPLVKELATPEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKIPIWIADYVLMDYGTGA 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 408 IMAVPAHDERDWEFARKYALPIREVVSDtptlglGGGSSPCQAEplEVFVGEGYAIHSGPLDGLSTADAKVEIVRQLTGR 487
Cdd:COG0495 337 VMAVPAHDQRDFEFAKKYGLPIKQVIAP------EDGDDPDILE--EAYTGDGVLINSGEFDGLDSEEAKEAIIEWLEEK 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 488 GLARKTINYKLRDWLFSRQRYWGEPFPIV-WEDGKHRALPDTHLPVNPPPLDDFKPtgTGEPPLAKATQWVRYSD----- 561
Cdd:COG0495 409 GLGKRKVNYRLRDWLISRQRYWGEPIPIIhCEDCGVVPVPEDQLPVELPEDVDFDP--TGGSPLARAPEWVNVTCpkcgg 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 562 KATRETNTMPQWAGSCWYYLRYCDPVNHNRFVGVDAERYWMtgtveqPagakvrpggVDLYVGGTEHAVLHLLYARFWHK 641
Cdd:COG0495 487 PARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWL------P---------VDQYIGGIEHAILHLLYARFFTK 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 642 VLFDLGYVSTPEPFQRLVNQGII--LGEDG------QKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPWSMA 713
Cdd:COG0495 552 VLRDLGLVSFDEPFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDS 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 714 GVEGVARFLARVWRLAVEENQAGEWVLSSAlqdIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFVNTFTNAN-- 791
Cdd:COG0495 632 GVEGAYRFLNRVWRLVVDEAEALKLDVADL---SEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELVNALYKAKds 708
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 792 -----PRPRKALRSLLQVLNPFAPHLTEELWERLGFDENgakpLATEPWPAYDAALLVEDEIEIVLQVNGKVRDKIIVKK 866
Cdd:COG0495 709 geadrAVLREALETLVLLLAPFAPHIAEELWERLGHEGS----VADAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPA 784
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 494040520 867 EASKEEVEAAARASSKIAEWTAGKEIKKVVVVPGKLVNIVVA 908
Cdd:COG0495 785 DASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
2-907 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 1237.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 2 STERRRPYPYDQIEPKWQERWESARTFHAPNpgdpGFDPARPKYYVLDMFPYPSGAGLHVGHPEGYTATDIIGRYKKMRG 81
Cdd:PLN02563 73 TPAAKRAYPFHEIEPKWQRYWEENRTFRTPD----DVDTSKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 82 CNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLRLYhsyfdp 161
Cdd:PLN02563 149 YNVLHPMGWDAFGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLL------ 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 162 flqksrpislledaladepKRTdewkdddylaglrahsgdlpperrravreaiidhhrLAYVSEAPVNWCPALGTVLANE 241
Cdd:PLN02563 223 -------------------KRG------------------------------------LAYQAEVPVNWCPALGTVLANE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 242 EVIDGKSEVGGHPVERRPMRQWMLRITTYAQRLIDELDGLDWPESIKLLQRNWIGRSEGAEVQFTVAG-----SEEKITV 316
Cdd:PLN02563 248 EVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLDgegkeRDEKITV 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 317 FTTRPDTLYGATYMVLAPEHPLVERIVTEEQAGAVEEYKEKTARKSDLERTELSKEKTGVWTGAFAINPVNVERIPIWIA 396
Cdd:PLN02563 328 YTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAINPATGEAIPIWVA 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 397 DYVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDtptlGLGGGSSPCQAeplevFVGEGYAIHSG----PLDGLS 472
Cdd:PLN02563 408 DYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKP----ADGNEDDAEKA-----YTGEGVIVNSSssglDINGLS 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 473 TADAKVEIVRQLTGRGLARKTINYKLRDWLFSRQRYWGEPFPIVW--EDGKHRALPDTHLPVNPPPLDDFKPTGTGEPPL 550
Cdd:PLN02563 479 SKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFleDSGEPVPVPESDLPLTLPELDDFTPTGTGEPPL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 551 AKATQWVRYSDK-----ATRETNTMPQWAGSCWYYLRYCDPVNHNRFVGVDAERYWMTgtveqpagakvrpggVDLYVGG 625
Cdd:PLN02563 559 AKAVSWVNTVDPssgkpARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMP---------------VDLYVGG 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 626 TEHAVLHLLYARFWHKVLFDLGYVSTPEPFQRLVNQGIILGE---------DGQ-------------------------- 670
Cdd:PLN02563 624 AEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMILGEveytafkdsDGEyvsadtadrlgelqqekipeekviks 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 671 -------------------KMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVWRLAV- 730
Cdd:PLN02563 704 gdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVg 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 731 EENQAGEWVLSSALQDIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFVNTFTNANPRPRKALRSLLQVLNPFAP 810
Cdd:PLN02563 784 APLPDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWDKVPREAIEPFVLLLSPYAP 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 811 HLTEELWERLGFDENgakpLATEPWPAYDAALLVEDEIEIVLQVNGKVRDKIIVKKEASKEEVEAAARASSKIAEWTAGK 890
Cdd:PLN02563 864 HLAEELWFRLGHSNS----LAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGK 939
|
970
....*....|....*..
gi 494040520 891 EIKKVVVVPGKLVNIVV 907
Cdd:PLN02563 940 EIKKRIYVPGKILNVIL 956
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
9-908 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1069.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 9 YPYDQIEPKWQERWESARTFHAPNpgdpgfDPARPKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPM 88
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTD------DSSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 89 GWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLRLYHsyfdpflqksrp 168
Cdd:TIGR00396 74 GWDAFGLPAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFE------------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 169 islledaladepkrtdewkdddylAGLrahsgdlpperrravreaiidhhrlAYVSEAPVNWCPALGTVLANEEVI-DGK 247
Cdd:TIGR00396 142 ------------------------KGL-------------------------AYVKEADVNWCPNDGTVLANEQVDsDGR 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 248 SEVGGHPVERRPMRQWMLRITTYAQRLIDELDGLD-WPESIKLLQRNWIGRSEGAEVQFTVAGSEEKITVFTTRPDTLYG 326
Cdd:TIGR00396 173 SWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHDEKITVFTTRPDTIFG 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 327 ATYMVLAPEHPLVERIVTEEQagAVEEYKEKTARKSDLERTELSKEKTGVWTGAFAINPVNVERIPIWIADYVLLGYGTG 406
Cdd:TIGR00396 253 VTYLALAPEHPLVEKAAENNP--KVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIWVANYVLMEYGTG 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 407 AIMAVPAHDERDWEFARKYALPIREVVsdtptlglgggSSPCQAEPLEV-FVGEGYAIHSGPLDGLSTADAKVEIVRQLT 485
Cdd:TIGR00396 331 AVMGVPAHDERDFEFAQKYGLPIKPVI-----------DPAEKDLSLTAaYTEDGVLVNSGEFNGLNSSEARNAIIDMLE 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 486 GRGLARKTINYKLRDWLFSRQRYWGEPFPIV-WEDGKHRALPDTHLPVNPPPLDDFKPtgTGEPPLAKATQWVRYSD--- 561
Cdd:TIGR00396 400 KEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIhCEDGGVVPVPEEDLPVILPEDVVYDG--DGGSPLSRIPEWVNVTCpsc 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 562 --KATRETNTMPQWAGSCWYYLRYCDPVNHNRFVGVDAERYWMtgtveqPagakvrpggVDLYVGGTEHAVLHLLYARFW 639
Cdd:TIGR00396 478 gkPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWL------P---------VDLYIGGIEHAILHLLYARFF 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 640 HKVLFDLGYVSTPEPFQRLVNQGIILG----EDGQ---------------------------KMSKSRGNVVNPDDVITE 688
Cdd:TIGR00396 543 HKFLRDIGYVNTKEPFKKLINQGMVLGfyypPNGKvpadvlterdekgkdkaggelvyvgyeKMSKSKGNGIDPQEIVES 622
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 689 YGADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVWRLAVEENQAGEWVLSSALQDIEPDKAQLKVIHATIKKVGEDI 768
Cdd:TIGR00396 623 YGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDL 702
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 769 ESL-GFNTAISQMMIFVNTFTNAN--PRPRKALRSLLQVLNPFAPHLTEELWERLGFDENGAKplaTEPWPAYDAALLVE 845
Cdd:TIGR00396 703 EKReSFNTAISAMMELLNKLYKAKkeALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIID---NAKWPVVDETALVE 779
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494040520 846 DEIEIVLQVNGKVRDKIIVKKEASKEEVEAAARASSKIAEWTAGKEIKKVVVVPGKLVNIVVA 908
Cdd:TIGR00396 780 DKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
292-485 |
9.51e-89 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 279.82 E-value: 9.51e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 292 RNWIGRSEGAEVQFTVAGSEEKITVFTTRPDTLYGATYMVLAPEHPLVERIvtEEQAGAVEEYKEKTARKSDLERTELSK 371
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKL--AEKNPEVAAFIEECKNTSEIERTSETK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 372 EKTGVWTGAFAINPVNVERIPIWIADYVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVsdtptlgLGGGSSPCQAE 451
Cdd:pfam13603 79 EKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVI-------QPEDGDLDLDI 151
|
170 180 190
....*....|....*....|....*....|....
gi 494040520 452 PLEVFVGEGYAIHSGPLDGLSTADAKVEIVRQLT 485
Cdd:pfam13603 152 MTEAYTEEGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
9-859 |
2.73e-68 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 244.20 E-value: 2.73e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 9 YPYDQIEPKWQERWESARTFhapnpgDPGFDPARPKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPM 88
Cdd:TIGR00422 5 YDPHEVEKKWYKKWEKSGFF------KPDGNSNKPPFCIDIPPPNVTGS-LHIGHALNWSIQDIIARYKRMKGYNVLWLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 89 GWDAFGLPAE-----QYAIKT------GQHPSVT-----TAENVGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFL 152
Cdd:TIGR00422 78 GTDHAGIATQvkvekKLGAEGktkhdlGREEFREkiwewKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 153 RLYhsyfdpflqksrpislledaladepkrtdewkdddylaglrahsgdlpperrravREAIIdhhrlaYVSEAPVNWCP 232
Cdd:TIGR00422 158 RLY-------------------------------------------------------EKGLI------YRGEYLVNWDP 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 233 ALGTVLANEEVIDgkSEVGGHpverrpmrqwmlrittyaqrlideLDGLDWPesikllqrnwigrsegaevqftVA-GSE 311
Cdd:TIGR00422 177 KLNTAISDIEVEY--KEVKGK------------------------LYYIRYP----------------------LAnGSK 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 312 EKITVFTTRPDTLYGATYMVLAPEHplverivteeqagavEEYKEktarksdlertelskektgvWTGAFAINPVNVERI 391
Cdd:TIGR00422 209 DYLVVATTRPETMFGDTAVAVHPED---------------ERYKH--------------------LIGKKVILPLTGRKI 253
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 392 PIwIAD-YVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLGLgggsspcqaeplevfvgegyaiHSGPLDG 470
Cdd:TIGR00422 254 PI-IADeYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNE----------------------NAGKYQG 310
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 471 LSTADAKVEIVRQLTGRGLARKTINYK----------------------------------------------------- 497
Cdd:TIGR00422 311 LTRFEARKKIVEDLKEEGLLVKIEPHThnvgtcwrsgtvvepllskqwfvkvekladkaleaaeegeikfvpkrmekryl 390
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 498 -----LRDWLFSRQRYWGEPFPiVWedgKHRALPDTHLPVNPPPLDDfkPTGTGepplakatqwvrYSDKATRETNTMPQ 572
Cdd:TIGR00422 391 nwlrnIKDWCISRQLIWGHRIP-VW---YCKECGEVYVAKEEPLPDD--KTNTG------------PSVELEQDTDVLDT 452
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 573 WAGSCWYYLRYCDPVNHNrfvgVDAERYWMTgtveqpagaKVRPGGVDLYvggtehavlhllyaRFWHKVLFDLGYVSTP 652
Cdd:TIGR00422 453 WFSSSLWPFSTLGWPDET----KDLKKFYPT---------DLLVTGYDII--------------FFWVARMIFRSLALTG 505
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 653 E-PFQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVW----- 726
Cdd:TIGR00422 506 QvPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWnasrf 585
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 727 ------------RLAVEENQAGEWVLSSALQdiepdkaqlkvihaTIKKVGEDIESLGFNTAISQMMIFV---------- 784
Cdd:TIGR00422 586 vlmnlsddlelsGGEEKLSLADRWILSKLNR--------------TIKEVRKALDKYRFAEAAKALYEFIwndfcdwyie 651
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 785 ---NTFTNANPRPRKALRS--------LLQVLNPFAPHLTEELWERLGfdeNGAKPLATEPWPAYDAALL---VEDEIEI 850
Cdd:TIGR00422 652 lvkYRLYNGNEAEKKAARDtlyyvldkALRLLHPFMPFITEEIWQHFK---EGADSIMLQSYPVVDAEFVdeeAEKAFEL 728
|
....*....
gi 494040520 851 VLQVNGKVR 859
Cdd:TIGR00422 729 LKEIIVSIR 737
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
9-898 |
1.09e-64 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 232.78 E-value: 1.09e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 9 YPYDQIEPKWQERWESARTFHapnpgdpgFDP-ARPKYYVLDMFP-YPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLH 86
Cdd:PRK13208 10 YDPEELEEKWQKIWEEEGTYK--------FDPdERKPVYSIDTPPpTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 87 PMGWDAFGLPAEQYAIKT-GQHPSVT------------TAENVGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLR 153
Cdd:PRK13208 81 PQGWDDNGLPTERKVEKYyGIRKDDIsreefielcrelTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 154 LYHsyfdpflqksrpislledaladepkrtdewkdddylAGlrahsgdlpperrravreaiidhhrLAYVSEAPVNWCPA 233
Cdd:PRK13208 161 LYK------------------------------------KG-------------------------LIYRAEAPVLWCPR 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 234 LGTVLANEEVIDgkSEVGGHpverrpmrqwMLRITtyaqrlideldgldwpesikllqrnwigrsegaevqFTVAGsEEK 313
Cdd:PRK13208 180 CETAIAQAEVEY--REREGK----------LNYIK------------------------------------FPVED-GEE 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 314 ITVFTTRPDtLYGATYMVLApeHPLVERivteeqagaveeYKektarksDLErtelskektgvwtGAFAINPV-NVErIP 392
Cdd:PRK13208 211 IEIATTRPE-LLPACVAVVV--HPDDER------------YK-------HLV-------------GKTAIVPLfGVE-VP 254
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 393 IwIAD-YVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLglgggsspcqaepLEVFvgegyaihsGPLDGL 471
Cdd:PRK13208 255 I-LADpLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRM-------------TEAA---------GKLAGL 311
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 472 STADAKVEIVRQLTGRGLARKT------------------------------------------IN-----YKLR----- 499
Cdd:PRK13208 312 TIEEARKKIVEDLKSGGLLGKQepikhnvkfcercdtpleilvtrqwfikvldlkeellergkeINwypehMRVRlenwi 391
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 500 -----DWLFSRQRYWGEPFPiVW--EDGKHRALPDT-HLPVNppPLDDfkptgtgEPPLAKATQwvRYSDKATRETNTMP 571
Cdd:PRK13208 392 eglnwDWCISRQRYFGTPIP-VWycKDCGHPILPDEeDLPVD--PTKD-------EPPGYKCPQ--CGSPGFEGETDVMD 459
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 572 QWAGS--------CWyylrycdPVNHNRFvgvdAERYWMTgtveqpagakVRPGGVD-----LYvggteHAVL--HLLYA 636
Cdd:PRK13208 460 TWATSsitplivtGW-------ERDEDLF----EKVFPMD----------LRPQGHDiirtwLF-----YTILraYLLTG 513
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 637 RF-WHKVlfdlgyvstpepfqrLVNqGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRcYEMFMGPLEQTKPWSMAGV 715
Cdd:PRK13208 514 KLpWKNI---------------MIS-GMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YWAASARLGSDTPFDEKQV 576
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 716 EGVARFLARVW---RLAVEENQAGEWVLSSALQDIepDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFV-NTFT--- 788
Cdd:PRK13208 577 KIGRRLLTKLWnasRFVLHFSADPEPDKAEVLEPL--DRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCddy 654
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 789 ------------NANPRP------RKALRSLLQVLNPFAPHLTEELWERLgfdenGAKPLATEPWPAYDAALLVED---E 847
Cdd:PRK13208 655 lelvksraygedEEEEQKsarytlYTVLDTLLRLLAPFLPFITEEVWSWL-----YGGSVHRASWPEPDEELIDEEdeeL 729
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 848 IEIVLQVNGKVR--------------DKIIVKKEASKEEVEAAA---RASSKIA--EWTAGKEIKKVVVV 898
Cdd:PRK13208 730 GELAKEILSAVRkykseaglslnaplKKVEVYGPADLELLEAAEedlKAAGNIEelELVEGDPELEVEII 799
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
44-296 |
6.96e-64 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 217.89 E-value: 6.96e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 44 KYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQL 123
Cdd:cd00812 1 KFYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 124 KKIGFAYDWQREVNTTDPGYYCWTQWIFLRLYhsyfdpflqksrpislledaladepkrtdewkdddylaglrahsgdlp 203
Cdd:cd00812 80 KRMGFSYDWRREFTTCDPEYYKFTQWLFLKLY------------------------------------------------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 204 perrravreaiidHHRLAYVSEAPVNWCpalgtvlaneevidgksevgghpverRPMRQWMLRI--TTYAQRLIDELDGL 281
Cdd:cd00812 112 -------------EKGLAYKKEAPVNWC--------------------------KLLDQWFLKYseTEWKEKLLKDLEKL 152
|
250
....*....|....*.
gi 494040520 282 D-WPESIKLLQRNWIG 296
Cdd:cd00812 153 DgWPEEVRAMQENWIG 168
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
498-710 |
2.60e-52 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 185.53 E-value: 2.60e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 498 LRDWL-FSRQRYWGEPFPIvwedgkhralpdthlpvnppplddfkptgtgepplakatqwvrysdkatreTNTMPQWAGS 576
Cdd:cd00812 163 QENWIgCSRQRYWGTPIPW---------------------------------------------------TDTMESLSDS 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 577 CWYYLRYCDPVNHNRFVGVDAER------YWMtgtveqpagakvrPggVDLYVGGTEHAVLHLLYARFWHKVLFDLGYVs 650
Cdd:cd00812 192 TWYYARYTDAHNLEQPYEGDLEFdreefeYWY-------------P--VDIYIGGKEHAPNHLLYSRFNHKALFDEGLV- 255
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 651 TPEPFQRLVNQGIILGEdGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPW 710
Cdd:cd00812 256 TDEPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
710-820 |
6.55e-46 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 160.08 E-value: 6.55e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 710 WSMAGVEGVARFLARVWRLAVEENQAGEWVLSSAlQDIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFVNTFTN 789
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAA-ELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYK 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 494040520 790 ANPR-------PRKALRSLLQVLNPFAPHLTEELWERL 820
Cdd:cd07958 80 YKKKdaqhaavLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
59-897 |
2.24e-42 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 167.35 E-value: 2.24e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 59 LHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLP----AEQ---------------YAIKTGQHPSVTTAENVGRF 119
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERiargdpetielykslYGIPEEELEKFKDPEYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 120 -----RTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLRLyhsyfdpflqksrpislledaladepkrtdewKDDDYLag 194
Cdd:PRK12300 81 fseeaKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKL--------------------------------KEKGLI-- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 195 lrahsgdlpperrraVREaiiDHhrlayvseaPVNWCPALGTVlaneevidgkseVGGHpverrpmrqwmlrittyaqrl 274
Cdd:PRK12300 127 ---------------VKG---SH---------PVRYCPNDNNP------------VGDH--------------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 275 iDELDGldwpesikllqrnwigrsEGAE-VQFTV---AGSEEKITV-FTTRPDTLYGATYMVLAPEhplVERIVTEeqag 349
Cdd:PRK12300 147 -DLLDG------------------EEPEiVEYTLikfEESEDLILPaATLRPETIFGVTNLWVNPD---ATYVKAE---- 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 350 aVEEYK----EKTARK---SDLERTELSKEKTGVWTGAFAINPVNVERIPIWIADYVLLGYGTGAIMAVPAHDERDWefa 422
Cdd:PRK12300 201 -VDGEKwivsKEAAEKlsfQDRDVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDY--- 276
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 423 rkYALpiREVVSDTPTLGL----------GGGSSPC-----------QAEP-LEVFVGEGYAI---------HSGPLDGL 471
Cdd:PRK12300 277 --VAL--RDLKKNKELLDViepiplieveGYGEFPAkevveklgiksQEDPeLEEATKEVYRAefhkgvlkeNTGEYAGK 352
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 472 STADAKVEIVRQLTGRGLA-------------------------------------------------------RKTINY 496
Cdd:PRK12300 353 PVREAREKITKDLIEKGIAdimyefsnrpvycrcgtecvvkvvkdqwfidysdpewkelahkaldnmeiipeeyRKEFEN 432
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 497 K---LRDWLFSRQRYWGEPFPivWEDGkhralpdthlpvnppplddfkptgtgepplakatqWV--RYSD---------- 561
Cdd:PRK12300 433 TidwLKDRACARRRGLGTRLP--WDEE-----------------------------------WIieSLSDstiymayyti 475
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 562 -KATRETNTMP-QWAGSCWYY--LRYCDPVNHNRFVGVDAE---------RYWMtgtveqpagakvrpgGVDLYVGGTEH 628
Cdd:PRK12300 476 aHKIREYGIKPeQLTPEFFDYvfLGKGDPEEVSKKTGIPKEileemreefLYWY---------------PVDWRHSGKDL 540
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 629 AVLHLLYARFWHKVLFdlgyvstPE---PFQRLVNqGIILGEdGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLE 705
Cdd:PRK12300 541 IPNHLTFFIFNHVAIF-------PEekwPRGIVVN-GFVLLE-GKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELL 611
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 706 QTKPWSMAGVEGVARFLARVWRLAVEENQAGEwvlSSALQDIepDKAQLKVIHATIKKVGEDIESLGFNTAIsQMMIFvn 785
Cdd:PRK12300 612 QDADWREKEVESVRRQLERFYELAKELIEIGG---EEELRFI--DKWLLSRLNRIIKETTEAMESFQTRDAV-QEAFY-- 683
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 786 TFTNA--------NPRPRKALRSLLQV----LNPFAPHLTEELWERLGfdenGAKPLATEPWPAYDaALLVEDEIEIVLQ 853
Cdd:PRK12300 684 ELLNDlrwylrrvGEANNKVLREVLEIwirlLAPFTPHLAEELWHKLG----GEGFVSLEKWPEPD-ESKIDEEAELAEE 758
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*....
gi 494040520 854 VNGKVRDKI-----IVKKEASKEEVEAAARASSKIAEWTAGKEIKKVVV 897
Cdd:PRK12300 759 YVKRLIEDIreilkVAKIKPKKVYIYVAPDWKYEVLEIAAENGDVKEAI 807
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-697 |
2.59e-41 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 161.04 E-value: 2.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 17 KWQERWESARTFHAPNPGDPGfdpaRPKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLP 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKG----KPSFTIHDGPPNATGS-LHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 97 AEQ-----YAIKTGQHPSVTTAEN------------VGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLRLYhsyf 159
Cdd:pfam00133 76 TEQvvekkLGIKEKKTRHKYGREEfrekcrewkmeyADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLH---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 160 dpflqksrpislledalaDEPkrtdewkdddylaglrahsgdlpperrravreaiidhhrLAYVSEAPVNWCPALGTVLA 239
Cdd:pfam00133 152 ------------------DKG---------------------------------------LIYRGKKLVNWSPALNTALS 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 240 NEEVIDgksevgghpverrpmrqwmlrittyaqrliDELDGLDWpesikllqrnwigrsegaEVQFTVAGSEE-KITVFT 318
Cdd:pfam00133 175 NLEVEY------------------------------KDVKGPSI------------------HVAFPLADDEGaSLVIWT 206
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 319 TRPDTLYGATYMVLAPEhplvERIVTEEQAGAVEEYKEKTARKSDLERTELSKEKTGVWTGAFAINPVNVERIPIWIADY 398
Cdd:pfam00133 207 TTPWTLPGNTAVAVNPE----FDYVITGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPFVNREIPIITDDY 282
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 399 VLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLGLGGgsspcqaeplevfvgegyaihsGPLDGLSTADAKV 478
Cdd:pfam00133 283 VDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEA----------------------PDFQGVYRFDARK 340
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 479 EIVRQLTGRGL----------------ARKTINYKL----------------------------------------RDWL 502
Cdd:pfam00133 341 KIVELLTEKGLllkiepfthsypfcwrSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekryfnwlaniQDWC 420
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 503 FSRQRYWGEPFPiVWEDgkhralPDTHLPVNPPPLDDFKPTGTGEPplAKATQWVRYS--------DKATRETNTMPQW- 573
Cdd:pfam00133 421 ISRQRWWGHPIP-AWVS------KDTEEVVCRGELFELVAGRFEEE--GSIKWLHREAkdklgygkGTLEQDEDVLDTWf 491
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 574 -AGScwyylrycdpvnhnrfvgvdaeryWMTGTVEQP---AGAKVRPGGVDLYVGGTEHavlhllyARFWHKVLFDLGYV 649
Cdd:pfam00133 492 sSGS------------------------WPFSTLGWPfvnTEEFKKFFPADMLLEGSDQ-------TRGWFYRMIMLSTA 540
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 494040520 650 ST-PEPFQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCY 697
Cdd:pfam00133 541 LTgSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLW 589
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
11-859 |
1.23e-33 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 139.47 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 11 YD--QIEPKWQERWESARTFHApnpgdpgfDPARPKYYVLdMFPYPSGAG-LHVGHpeGYTAT--DIIGRYKKMRGCNVL 85
Cdd:PRK05729 9 YDpkEVEAKWYQKWEEKGYFKP--------DDNSKKPFSI-VIPPPNVTGsLHMGH--ALNNTlqDILIRYKRMQGYNTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 86 ---------------------------HPMGWDAFgLP-----AEQYAiktgqhpsvttaenvGRFRTQLKKIGFAYDWQ 133
Cdd:PRK05729 78 wlpgtdhagiatqmvverqlaaegksrHDLGREKF-LEkvwewKEESG---------------GTITNQLRRLGASCDWS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 134 REVNTTDPGYYcwtqwiflrlyhsyfdpflqksrpislledaladepkrtdewkdddylaglrahsgdlpperrRAVREA 213
Cdd:PRK05729 142 RERFTMDEGLS---------------------------------------------------------------KAVREV 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 214 IIDHHR--LAYVSEAPVNWCPALGTVLANEEVIDgkSEVGGHpverrpMrqWMLRittYAqrlideldgldwpesikllq 291
Cdd:PRK05729 159 FVRLYEkgLIYRGKRLVNWDPKLQTALSDLEVEY--KEVKGK------L--WHIR---YP-------------------- 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 292 rnwigrsegaevqftVAGSEEKITVFTTRPDTLYGATY-MVlapeHPLVERivteeqagaveeYKektarksDLErtels 370
Cdd:PRK05729 206 ---------------LADGSDYLVVATTRPETMLGDTAvAV----NPEDER------------YK-------HLI----- 242
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 371 kektgvwtGAFAINPVNVERIPIwIAD-YVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLglgggsspcq 449
Cdd:PRK05729 243 --------GKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTI---------- 303
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 450 aeplevfvgegyAIHSGPLDGLSTADAKVEIVRQLTGRGLARKTINYK-------------------------------- 497
Cdd:PRK05729 304 ------------NENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHThsvghsdrsgvviepylsdqwfvkmkplakpa 371
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 498 --------------------------LRDWLFSRQRYWGEPFPiVWEDgkhralPDTHLPVNPPplddfkptgtgEPPLA 551
Cdd:PRK05729 372 leavengeikfvperwektyfhwmenIQDWCISRQLWWGHRIP-AWYD------EDGEVYVGRE-----------EPEAR 433
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 552 KATQWVRYSD-------KATretntmpqWAGSC--WyylrycdPvNHNRfvgvDAERYWMTgtveqpagakvrpggvDLY 622
Cdd:PRK05729 434 EKALLTQDEDvldtwfsSAL--------WPFSTlgW-------P-EKTE----DLKRFYPT----------------SVL 477
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 623 VGGtehavlhllyarfwhkvlFD-----------LGYVSTPE-PFQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEYG 690
Cdd:PRK05729 478 VTG------------------FDiiffwvarmimMGLHFTGQvPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYG 539
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 691 ADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVW---RLA---VEENQAGEWVLSSALQDIepDKAQLKVIHATIKKV 764
Cdd:PRK05729 540 ADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWnasRFVlmnLEGADVGELPDPEELSLA--DRWILSRLNRTVAEV 617
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 765 GEDIESLGFNTAISQMMIFV-NTF------------TNANPRP-----RKALRSLLQVLNPFAPHLTEELWERLGfDENG 826
Cdd:PRK05729 618 TEALDKYRFDEAARALYEFIwNEFcdwylelakpvlQEAAKRAtratlAYVLEQILRLLHPFMPFITEELWQKLA-PLGI 696
|
970 980 990
....*....|....*....|....*....|....*
gi 494040520 827 AKPLATEPWPAYDAALL--VEDEIEIVLQVNGKVR 859
Cdd:PRK05729 697 EESIMLAPWPEADEAIDeaAEAEFEWLKELITAIR 731
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
11-885 |
2.42e-33 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 138.65 E-value: 2.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 11 YD--QIEPKWQERWESARTFHapnpgdPGFDPARPKYYVldMFPYP--SGAgLHVGHPEGYTATDIIGRYKKMRGCNVL- 85
Cdd:COG0525 7 YDpkEVEAKWYQYWEENGYFK------ADPDSDKEPFTI--VIPPPnvTGS-LHMGHALNNTLQDILIRYKRMQGYNTLw 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 86 --------------------------HPMGWDAFgLP-----AEQYAiktgqhpsvttaenvGRFRTQLKKIGFAYDWQR 134
Cdd:COG0525 78 qpgtdhagiatqavverqlaeegksrHDLGREKF-LErvwewKEESG---------------GTITNQLRRLGASCDWSR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 135 EVNTTDPGYYcwtqwiflrlyhsyfdpflqksrpislledaladepkrtdewkdddylaglrahsgdlpperrRAVREAI 214
Cdd:COG0525 142 ERFTMDEGLS---------------------------------------------------------------KAVREVF 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 215 IDHHR--LAYVSEAPVNWCPALGTVLANEEVIdgKSEVGGHpverrpMrqWMLRittYAqrlideldgldwpesikllqr 292
Cdd:COG0525 159 VRLYEkgLIYRGKRLVNWDPKLKTALSDLEVE--HEEVKGH------L--WHIR---YP--------------------- 204
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 293 nwigrsegaevqftVAGSEEKITVFTTRPDTLYGATY-MVlapeHPLVERivteeqagaveeYKektarksDLertelsk 371
Cdd:COG0525 205 --------------LADGSGYIVVATTRPETMLGDTAvAV----HPEDER------------YK-------HL------- 240
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 372 ektgvwTGAFAINPVNVERIPIwIAD-YVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLGLGGGsspcqa 450
Cdd:COG0525 241 ------IGKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAG------ 307
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 451 eplevfvgegyaihsgPLDGLSTADAKVEIVRQLTGRGLARKTINYKL-------------------------------- 498
Cdd:COG0525 308 ----------------KYRGLDRFEARKAIVADLEELGLLVKVEPHKHsvghsdrsgtviepylsdqwfvkmkplakpai 371
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 499 --------------------------RDWLFSRQRYWGepfpivwedgkHRalpdthLPVnppplddfkptgtgepplak 552
Cdd:COG0525 372 eavedgeikfvperwektyfhwmeniRDWCISRQLWWG-----------HR------IPA-------------------- 414
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 553 atqwvrysdkatretntmpqwagscWYylryCDpvNHNRFVGVDAErywmtgtvEQPAGAkvrpGGVDLY----V----- 623
Cdd:COG0525 415 -------------------------WY----CP--DGEVYVARTEP--------EACAKA----GSVNLTqdedVldtwf 451
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 624 ----------GGTEHAvlhLLYARFwH--KVL---FD-----------LGYVSTPE-PFQRLVNQGIILGEDGQKMSKSR 676
Cdd:COG0525 452 ssalwpfstlGWPEKT---EDLKYF-YptSVLvtgFDiiffwvarmimMGLHFTGEvPFKDVYIHGLVRDEQGRKMSKSK 527
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 677 GNVVNPDDVITEYGADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVW---RLA---VEENQAGEWVLSSALQDIepD 750
Cdd:COG0525 528 GNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWnasRFVlmnLEGFDPGLDPDPEELSLA--D 605
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 751 KAQLKVIHATIKKVGEDIESLGFNTAISQMMIFV-NTF------------TNANPRPRKA--------LRSLLQVLNPFA 809
Cdd:COG0525 606 RWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFcdwylelakprlYGGDEAAKREtratlvyvLEQILRLLHPFM 685
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 810 PHLTEELWERLGFDENGaKPLATEPWPAYDAALL---VEDEIEIVLQVNGKVRDkiiVKKE---ASKEEVEAAARASSKI 883
Cdd:COG0525 686 PFITEEIWQKLPPRKEG-ESIMLAPWPEADEELIdeeAEAEFEWLKEVISAIRN---IRAEmniPPSKKLPLLLKGADEA 761
|
..
gi 494040520 884 AE 885
Cdd:COG0525 762 DR 763
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
13-862 |
3.45e-31 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 131.74 E-value: 3.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 13 QIEPKWQERWESARTFH---APNPGdpgfdpaRPKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMG 89
Cdd:COG0060 20 KREPEILKFWEENDIYEksrEARAG-------RPKFVLHDGPPYANGD-IHIGHALNKILKDIIVRYKTMRGFDVPYVPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 90 WDAFGLPAE-----QYAIKTGQHPSVTTAE-----------NVGRFRTQLKKIGFAYDWQREVNTTDPGYY--CWtqWIF 151
Cdd:COG0060 92 WDCHGLPIElkvekELGIKKKDIEKVGIAEfrekcreyalkYVDEQREDFKRLGVWGDWDNPYLTMDPEYEesIW--WAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 152 LRLYhsyfdpflqksrpislledaladepkrtdewkDDDYLA-GLRahsgdlpperrravreaiidhhrlayvseaPVNW 230
Cdd:COG0060 170 KKLY--------------------------------EKGLLYkGLK------------------------------PVPW 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 231 CPALGTVLANeevidgkSEVGGHPVERRpmrqwmlriTTYAQ-RLIDElDGLDWPESIKLLqrnwigrsegaevqftvag 309
Cdd:COG0060 188 CPRCGTALAE-------AEVEYKDVTSP---------SIYVKfPVKDE-KALLLLEDAYLV------------------- 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 310 seekitVFTTRPDTL-------------------YGATYMVLApeHPLVERIVTEeqaGAVEEYK-EKTARKSDLERTEL 369
Cdd:COG0060 232 ------IWTTTPWTLpanlavavhpdidyvlvevTGGERLILA--EALVEAVLKE---LGIEDYEvLATFKGAELEGLRY 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 370 skektgvwTGAFAINPVNVERIPIWIADYVLLGYGTGAI-MAvPAHDERDWEFARKYALPIREVVSDtptlglgGGsspc 448
Cdd:COG0060 301 --------EHPFYYVVGYDRAHPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGKKYGLPVLNPVDD-------DG---- 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 449 qaepleVFVGEGyaihsGPLDGLSTADAKVEIVRQLTGRG--LARKTI--NY-----------------------KLR-- 499
Cdd:COG0060 361 ------RFTEEA-----PLFAGLFVKDANPAIIEDLKERGalLAREKIthSYphcwrcktpliyratpqwfismdKLRdr 429
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 500 ---------------------------DWLFSRQRYWGEPFPIvW--EDGKHrALPDTHLP-----------VNPPPLDD 539
Cdd:COG0060 430 aleaiekvnwipewgegrfgnmlenrpDWCISRQRYWGVPIPI-WvcEDCGE-LHRTEEVIgsvaelleeegADAWFELD 507
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 540 FKptgtgEPPLAKATQWVRYSDKATRETNTMPQW--AGSCWYYlrycdpVNHNRfvgvDAERYwmtgtveqPAgakvrpg 617
Cdd:COG0060 508 LH-----RPFLDETLKCPKCGGTMRRVPDVLDVWfdSGSMHFA------VLENR----EELHF--------PA------- 557
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 618 gvDLYVGGT-EHavlhllyaRFW----HKV---LFDlgyvsTPePFQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEY 689
Cdd:COG0060 558 --DFYLEGSdQT--------RGWfyssLLTstaLFG-----RA-PYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKY 621
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 690 GADALRCYEMfmgpleQTKPW-----SMAGVEGVARFLARVW----------------RLAVEENQAGE---WVLSSAlq 745
Cdd:COG0060 622 GADILRLWVA------SSDYWgdlrfSDEILKEVRDVYRRLRntyrfllanlddfdpaEDAVPYEDLPEldrWILSRL-- 693
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 746 diepdkaqlkviHATIKKVGEDIESLGFNTAISQMMIFVNT-FTN--------------ANPRPRKA--------LRSLL 802
Cdd:COG0060 694 ------------NELIKEVTEAYDNYDFHRAYRALHNFCVEdLSNwyldiskdrlyteaADSLDRRAaqttlyevLETLV 761
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494040520 803 QVLNPFAPHLTEELWERLGFDEngAKPLATEPWPAYDAALL---VEDEIEIVLQVNGKVRDKI 862
Cdd:COG0060 762 RLLAPILPFTAEEIWQNLPGEA--EESVHLADWPEVDEELIdeeLEAKWDLVREVRSAVLKAL 822
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
46-695 |
1.76e-30 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 124.28 E-value: 1.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 46 YVLDMFP-YPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAE-----QYAIKTGQHPSVT-------- 111
Cdd:cd00817 3 FVIDTPPpNVTGS-LHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQvvvekKLGIEGKTRHDLGreeflekc 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 112 ---TAENVGRFRTQLKKIGFAYDWQREVNTTDPGYycwtqwiflrlyhsyfdpflqksrpislledaladepkrtdewkd 188
Cdd:cd00817 82 wewKEESGGKIREQLKRLGASVDWSREYFTMDPGL--------------------------------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 189 ddylaglrahsgdlpperRRAVREAIIDHHR--LAYVSEAPVNWCPALGTVLANEEVidgkSEVGGHPVERRPMRQWMLR 266
Cdd:cd00817 117 ------------------SRAVQEAFVRLYEkgLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEPLLKPQWFVK 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 267 ITTYAQRLIDELdgldwpesikllqrnwigrsEGAEVQFTvagseekitvfttrpdtlygatymvlaPEHplverivtee 346
Cdd:cd00817 175 VKDLAKKALEAV--------------------KEGDIKFV---------------------------PER---------- 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 347 qagaveeykektarksdlertelskektgvwtgafainpvnveripiWIADYvllgygtgaimavpahdeRDWefarkya 426
Cdd:cd00817 198 -----------------------------------------------MEKRY------------------ENW------- 205
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 427 lpirevvsdtptlglgggsspcqaepLEvfvgegyaihsgpldglstadakveivrqltgrglarktinyKLRDWLFSRQ 506
Cdd:cd00817 206 --------------------------LE------------------------------------------NIRDWCISRQ 217
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 507 RYWGEPFPiVW--EDGkhralpdTHLPVNPPPLDDFKPTGTGEPPLAKATQWVRysdkatrETNTMPQWAGScWYYLRYC 584
Cdd:cd00817 218 LWWGHRIP-AWycKDG-------GHWVVAREEDEAIDKAAPEACVPCGGEELKQ-------DEDVLDTWFSS-SLWPFST 281
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 585 -----DPVNHNRFVGVDaerywmtgtveqpagakVRPGGVDLYvggtehavlhllyaRFWHKVLFDLGYVSTPE-PFQRL 658
Cdd:cd00817 282 lgwpeETKDLKKFYPTS-----------------LLVTGHDII--------------FFWVARMIMRGLKLTGKlPFKEV 330
|
650 660 670
....*....|....*....|....*....|....*..
gi 494040520 659 VNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALR 695
Cdd:cd00817 331 YLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALR 367
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
3-820 |
1.59e-27 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 120.48 E-value: 1.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 3 TERRRPYPYDQIEPKWQERWESARTFHAPNpgdpgFDPARPKYYVLdmFPYPSGAG-LHVGHPEGYTATDIIGRYKKMRG 81
Cdd:PRK14900 13 TELAKGYEHREVEARWYPFWQERGYFHGDE-----HDRTRPPFSIV--LPPPNVTGsLHLGHALTATLQDVLIRWKRMSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 82 CNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGR-----------------FRTQLKKIGFAYDWQREVNTTDPGyy 144
Cdd:PRK14900 86 FNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGReaflervwawkeqygsrIGEQHKALGASLDWQRERFTMDEG-- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 145 cwtqwiflrlyhsyfdpflqksrpislledaladepkrtdewkdddylaglrahsgdlppeRRRAVREAIIDHHR--LAY 222
Cdd:PRK14900 164 -------------------------------------------------------------LSRAVREVFVRLHEegLIY 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 223 VSEAPVNWCPALGTVLANEEVIDGKSEVGghpverrpmRQWMLRittyaqrlideldgldwpesikllqrnwigrsegae 302
Cdd:PRK14900 183 REKKLINWCPDCRTALSDLEVEHEEAHQG---------ELWSFA------------------------------------ 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 303 vqFTVAGSEEKITVFTTRPDTLYGATYMVLapeHPLVERivteeqagaveeYKEKTARKsdlertelskektgvwtgafA 382
Cdd:PRK14900 218 --YPLADGSGEIVVATTRPETMLGDTAVAV---HPLDPR------------YMALHGKK--------------------V 260
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 383 INPVNVERIPIwIADYVLLG--YGTGAIMAVPAHDERDWEFARKYALPI--------------------------REVVS 434
Cdd:PRK14900 261 RHPITGRTFPI-VADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMitvigpdgrmtaeagplagldrfearKEVKR 339
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 435 DTPTLGLGGGSSP-------CQ--AEPLEVFVGEGYAIHSGPLdglstADAKVEIVRQLTGRGLARKTINY------KLR 499
Cdd:PRK14900 340 LLAEQGLDRGAKPhvlplgrCQrsATILEPLLSDQWYVRIEPL-----ARPAIEAVEQGRTRFIPEQWTNTymawmrNIH 414
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 500 DWLFSRQRYWGEPFPIVWedgkhraLPDTHLPVNppplddfKPTGTGEPPLAKATqwvrysdkATRETNTMPQWAGSC-W 578
Cdd:PRK14900 415 DWCISRQLWWGHQIPAWY-------CPDGHVTVA-------RETPEACSTCGKAE--------LRQDEDVLDTWFSSGlW 472
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 579 YYLRYCDPVNHNRFvgvdaERYWMTGTVEqpagakvrpggvdlyvggTEHAVLHLLYARFWHKVLFDLGYVstpePFQRL 658
Cdd:PRK14900 473 PFSTMGWPEQTDTL-----RTFYPTSVME------------------TGHDIIFFWVARMMMMGLHFMGEV----PFRTV 525
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 659 VNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVW---RLAVeENQA 735
Cdd:PRK14900 526 YLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWnasRFAL-MNLS 604
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 736 GEwvlssALQDIEPDKAQ--------LKVIHATIKKVGEDIESLGFNTAISQMMIFV-------------NTFTNANPRP 794
Cdd:PRK14900 605 GY-----QERGEDPARLArtpadrwiLARLQRAVNETVEALEAFRFNDAANAVYAFVwhelcdwyielakEALASEDPEA 679
|
890 900 910
....*....|....*....|....*....|....
gi 494040520 795 RKA--------LRSLLQVLNPFAPHLTEELWERL 820
Cdd:PRK14900 680 RRSvqavlvhcLQTSYRLLHPFMPFITEELWHVL 713
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
44-216 |
5.15e-25 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 106.73 E-value: 5.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 44 KYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTG-------------QHPSV 110
Cdd:cd00668 1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGgrkkktiwieefrEDPKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 111 TTAENVGRFRTQLKKIGFAYDWQREVNTTDPGYYCWTQWIFLRLYHS---YFDPFLQKSRPISLLedaladepkRTDEWK 187
Cdd:cd00668 80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKgliYRGTHPVRITEQWFF---------DMPKFK 150
|
170 180
....*....|....*....|....*....
gi 494040520 188 dDDYLAGLRahSGDLPPERRRAVREAIID 216
Cdd:cd00668 151 -EKLLKALR--RGKIVPEHVKNRMEAWLE 176
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
17-836 |
7.53e-24 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 108.49 E-value: 7.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 17 KWqerWESaRTFHAPNpGDPGFDParpkyYVLDMFPYPSGAGLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLp 96
Cdd:PLN02943 71 NW---WES-QGYFKPN-FDRGGDP-----FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 97 AEQYAIKtgqhpSVTTAENV----------------------GRFRTQLKKIGFAYDWQREVNTtdpgyycwtqwiflrl 154
Cdd:PLN02943 140 ATQLVVE-----KMLASEGIkrtdlgrdeftkrvwewkekygGTITNQIKRLGASCDWSRERFT---------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 155 yhsyfdpflqksrpislLEDALAdepkrtdewkdddylaglrahsgdlpperrRAVREAIIDHHR--LAYVSEAPVNWCP 232
Cdd:PLN02943 199 -----------------LDEQLS------------------------------RAVVEAFVRLHEkgLIYQGSYMVNWSP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 233 ALGTVLANEEVidGKSEVGGhpverrpmrqwmlriTTYaqrlideldgldwpesikllqrnwigrsegaEVQFTVAG-SE 311
Cdd:PLN02943 232 NLQTAVSDLEV--EYSEEPG---------------TLY-------------------------------YIKYRVAGgSE 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 312 EKITVFTTRPDTLYGATymvlapehplverivteeqAGAVEEYKEKTARksdlertelskektgvWTGAFAINPVNVER- 390
Cdd:PLN02943 264 DFLTIATTRPETLFGDV-------------------AIAVNPEDDRYSK----------------YIGKMAIVPMTYGRh 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 391 IPIwIAD-YVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTL----------------------GLGGGSSP 447
Cdd:PLN02943 309 VPI-IADrYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLnevaglywfeareklwsdleetGLAVKKEP 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 448 CQ---------AEPLEVFVGEGYAIHSGPLdglstADAKVEIVRQLTGRGLA---RKTINYKL---RDWLFSRQRYWGEP 512
Cdd:PLN02943 388 HTlrvprsqrgGEVIEPLVSKQWFVTMEPL-----AEKALKAVENGELTIIPerfEKIYNHWLsniKDWCISRQLWWGHR 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 513 FPIVWEDGKHRAlpdthlpvnppplDDFKPTGTGEPPLAKATQWVRYSDKATRETNTMPQW-AGSCWYYLRYCDPvnhnR 591
Cdd:PLN02943 463 IPVWYIVGKDCE-------------EDYIVARSAEEALEKAREKYGKDVEIYQDPDVLDTWfSSALWPFSTLGWP----D 525
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 592 FVGVDAERYWMTGTVEqpagakvrpggvdlyvggTEHAVLHLLYARFwhkVLFDLGYVSTPePFQRLVNQGIILGEDGQK 671
Cdd:PLN02943 526 VSAEDFKKFYPTTVLE------------------TGHDILFFWVARM---VMMGIEFTGTV-PFSYVYLHGLIRDSQGRK 583
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 672 MSKSRGNVVNPDDVITEYGADALRcYEMFMGPLEQTKPWSMAGVEGVARFLARVWrlaveenQAGEWVLSS--------- 742
Cdd:PLN02943 584 MSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTSNKAFTNKLW-------NAGKFVLQNlpsqsdtsa 655
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 743 --ALQDIEPDKAQ------------LKVIHATIKKVGEDIESLGFNTA------------------ISQMMIFVNTFTNA 790
Cdd:PLN02943 656 weHILACKFDKEEsllslplpecwvVSKLHELIDSVTTSYDKYFFGDVgreiydffwsdfadwyieASKTRLYHSGDNSA 735
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 494040520 791 NPRPRKAL----RSLLQVLNPFAPHLTEELWERLgfdENGAKPLATEPWP 836
Cdd:PLN02943 736 LSRAQAVLlyvfENILKLLHPFMPFVTEELWQAL---PYRKEALIVSPWP 782
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
750-873 |
9.64e-20 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 86.30 E-value: 9.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 750 DKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFV-NTFTN-----ANPRP-------------RKALRSLLQVLNPFAP 810
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDwylelIKDRLygeepdsraqttlYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494040520 811 HLTEELWERLgfdengakPLATEPWPAYDAALLVEDEIEI-----VLQVNGKVRDKIIVKKEASKEEV 873
Cdd:pfam08264 81 FITEELWQKE--------SIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
15-858 |
1.37e-19 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 94.45 E-value: 1.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 15 EPKWQERWESARTFH---APNPGDPgfdparpkyYVL-DMFPYPSGaGLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGW 90
Cdd:PLN02843 9 EPEIQKLWEENQVYKrvsDRNNGES---------FTLhDGPPYANG-DLHIGHALNKILKDFINRYQLLQGKKVHYVPGW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 91 DAFGLP-------------------------AEQYAIKTgqhpsvttaenVGRFRTQLKKIGFAYDWQREVNTTDPGYYC 145
Cdd:PLN02843 79 DCHGLPielkvlqsldqearkeltpiklrakAAKFAKKT-----------VDTQRESFKRYGVWGDWENPYLTLDPEYEA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 146 WTQWIFLRLYhsyfdpflqksrpislledaladepkrtdewkdddylagLRAHsgdlpperrravreaiidhhrlAYVSE 225
Cdd:PLN02843 148 AQIEVFGQMF---------------------------------------LNGY----------------------IYRGR 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 226 APVNWCPALGTVLANEEvidgksevgghpverrpmrqwmlrittyaqrlideldgLDWPESikllqrnwiGRSEGAEVQF 305
Cdd:PLN02843 167 KPVHWSPSSRTALAEAE--------------------------------------LEYPEG---------HVSKSIYVAF 199
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 306 TVAGSEEK-------------ITVFTTRPDTLYGATYMVLAPE--HPLVERIVTEEQAGAVEEYKEKTARKSDLER---- 366
Cdd:PLN02843 200 PVVSPSETspeeleeflpglsLAIWTTTPWTMPANAAVAVNDKlqYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQqklf 279
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 367 ----TELSK---EKTGV------------WTGAFAINPVNVERIPIWIA-DYVLLGYGTGAIMAVPAHDERDWEFARKYA 426
Cdd:PLN02843 280 livaTDLVPaleAKWGVklvvlktfpgsdLEGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYG 359
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 427 LPIREVVSD----TPTLG-------LGGGSSPCQA---EPLEVFVGEGYAiHSGPLDGLS--------TAD--AKVEIVR 482
Cdd:PLN02843 360 LPLLSPVDDagkfTEEAGqfsglsvLGEGNAAVVEaldEAGSLLMEEAYG-HKYPYDWRTkkptifraTEQwfASVEGFR 438
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 483 QLT-----------GRGLARKTINYKLR-DWLFSRQRYWGEPFPIvwedgkhralpdthlpvnppplddFKPTGTGEPPL 550
Cdd:PLN02843 439 QAAldaidkvkwipAQGENRIRAMVSGRsDWCISRQRTWGVPIPV------------------------FYHVETKEPLM 494
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 551 AKAT---------------QWV---------RYSDKA---TRETNTMPQW--AGSCWyylrycdpvnhnrfVGVDAERyw 601
Cdd:PLN02843 495 NEETiahvksivaqkgsdaWWYmdvedllpeKYRDKAsdyEKGTDTMDVWfdSGSSW--------------AGVLGSR-- 558
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 602 mtGTVEQPAgakvrpggvDLYVGGTEHavlHllyaRFWHKVLFdLGYVSTP--EPFQRLVNQGIILGEDGQKMSKSRGNV 679
Cdd:PLN02843 559 --EGLSYPA---------DLYLEGSDQ---H----RGWFQSSL-LTSVATKgkAPYKSVLTHGFVLDEKGFKMSKSLGNV 619
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 680 VNPDDVIT---------EYGADALRCY--------EMFMGP--LEQTKPwSMAGVEGVARFLArvwrlaveenqagewvl 740
Cdd:PLN02843 620 VDPRLVIEggknqkqepAYGADVLRLWvasvdytgDVLIGPqiLKQMSD-IYRKLRGTLRYLL----------------- 681
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 741 sSALQDIEP------------DKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFVNT------FTNANPR--------- 793
Cdd:PLN02843 682 -GNLHDWKPdnavpyedlpsiDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdlsnfyLDVAKDRlyvggttsf 760
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 794 PRKA--------LRSLLQVLNPFAPHLTEELWERLGFDENG--AKPLATEPWPAYDAALLVEDEIEI-----VLQVNGKV 858
Cdd:PLN02843 761 TRRScqtvlaahLLSLLRAIAPILPHLAEDAWQNLPFQEDGsaAESVFEAGWPTPNEEWLSFPAEDVdfwslLLEVRDEV 840
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
498-697 |
1.25e-18 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 88.06 E-value: 1.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 498 LRDWLFSRQRYWGEPFPIvwedgkhralpdthlpvnppplddFKPTGTGEPplakatqwvrysdKATRETNTMPQW--AG 575
Cdd:cd00818 189 RRDWCISRQRYWGTPIPV------------------------WYCEDCGEV-------------LVRRVPDVLDVWfdSG 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 576 SCWYYlrycdpVNHNRFVGVDAERYWmtgtveqPAgakvrpggvDLYVGGTEHA-----VLHLLYArfwhkVLFDLGyvs 650
Cdd:cd00818 232 SMPYA------QLHYPFENEDFEELF-------PA---------DFILEGSDQTrgwfySLLLLST-----ALFGKA--- 281
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 494040520 651 tpePFQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCY 697
Cdd:cd00818 282 ---PYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLW 325
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
14-444 |
2.09e-16 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 84.29 E-value: 2.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 14 IEPKWQERWESARTFHapnpgdPGFDPARP---KYYVLdMFPYPSGAG-LHVGHPEGYTATDIIGRYKKMRGCNVLHPMG 89
Cdd:PTZ00419 33 VESGWYEWWEKSGFFK------PAEDAKSLnsgKKFVI-VLPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVPG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 90 WDAFGLpAEQYAI-KTGQHPSVTTAENVGR-----------------FRTQLKKIGFAYDWQREVNTTDpgyycwtqwif 151
Cdd:PTZ00419 106 TDHAGI-ATQVVVeKKLMKEENKTRHDLGReeflkkvwewkdkhgnnICNQLRRLGSSLDWSREVFTMD----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 152 lrlyhsyfdpflqksrpislledaladEPkrtdewkdddylaglrahsgdlppeRRRAVREAIIDHHR--LAYVSEAPVN 229
Cdd:PTZ00419 174 ---------------------------EQ-------------------------RSKAVKEAFVRLYEdgLIYRDTRLVN 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 230 WCPALGTVLANEEV--IDGKSEVgghpverrpmrqwMLRITTYaQRLIDEldGLDWpesikllqrnwigrsegaEVQFTV 307
Cdd:PTZ00419 202 WCCYLKTAISDIEVefEEIEKPT-------------KITIPGY-DKKVEV--GVLW------------------HFAYPL 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 308 AGSEE-KITVFTTRPDTLYGATYMVLapeHPLVERivteeqagaveeYKEktarksdlertelskektgvWTGAFAINP- 385
Cdd:PTZ00419 248 EDSGQeEIVVATTRIETMLGDVAVAV---HPKDER------------YKK--------------------LHGKELIHPf 292
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494040520 386 VNVERIPIwIAD--YVLLGYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLGLGGG 444
Cdd:PTZ00419 293 IPDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGG 352
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
668-825 |
1.09e-15 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 81.31 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 668 DGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPWSmagvegVARFLARV-------W-----RLA--VEEN 733
Cdd:COG0143 324 EGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFS------WEDFVARVnsdlandLgnlasRTLsmIHKY 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 734 QAGewVLSSALQDIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFV---NTFTNAN-----------PRPRKALR 799
Cdd:COG0143 398 FDG--KVPEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALAraaNKYIDETapwklakdedpERLATVLY 475
|
170 180 190
....*....|....*....|....*....|...
gi 494040520 800 SLLQV-------LNPFAPHLTEELWERLGFDEN 825
Cdd:COG0143 476 TLLEAlrilailLKPFLPETAEKILEQLGLEGD 508
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
43-295 |
1.86e-15 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 80.54 E-value: 1.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 43 PKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQ 122
Cdd:COG0143 1 KKFLVTTAIPYANGP-PHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 123 LKKIGFAYD-WQRevnTTDPGYYCWTQWIFLRLY-------HSY---FDPflqksrpislledaladepkRTDEWKDDDY 191
Cdd:COG0143 80 FEKLGISFDnFIR---TTSPEHKELVQEIFQRLYdngdiykGEYegwYCP--------------------ECERFLPDRY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 192 LAGlrahsgdlpperrravrEAIIDHHRLAYVSEapvnwCPALGTVLANEEVIDGKSEVGGHPVERRPMRQWMLRITTYA 271
Cdd:COG0143 137 VEG-----------------TCPKCGAEDAYGDQ-----CENCGATLEPTELINPRSAISGAPPELREEEHYFFRLSKYQ 194
|
250 260
....*....|....*....|....*
gi 494040520 272 QRLIDELDGL-DWPESIKLLQRNWI 295
Cdd:COG0143 195 DRLLEWIEENpDIQPEVRNEVLSWL 219
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
668-835 |
4.84e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 78.77 E-value: 4.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 668 DGQKMSKSRGNVVNPDDVITEYGADALRCY---EMfmgPLEQTKPWSMAG-VEGVARFLA--------RVWRLAVEENQA 735
Cdd:PRK11893 296 DGEKMSKSLGNVIDPFDLVDEYGVDAVRYFllrEI---PFGQDGDFSREAfINRINADLAndlgnlaqRTLSMIAKNFDG 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 736 gewVLSSALQDIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFVNtFTNA--------------NPRPRKALRSL 801
Cdd:PRK11893 373 ---KVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVR-AANKyideqapwslaktdPERLATVLYTL 448
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 494040520 802 LQV-------LNPFAPHLTEELWERLGFDENGAKPLATEPW 835
Cdd:PRK11893 449 LEVlrgiavlLQPVMPELAAKILDQLGVEEDENRDFAALSW 489
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
498-710 |
1.88e-14 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 75.15 E-value: 1.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 498 LRDWLFSRQRYWGEPFPivwedgkhralpdthlpvnppplddfkptgtgepplakatQWVRYSdkatretntmpqWAGSC 577
Cdd:cd00668 178 LLDWAISRQRYWGTPLP----------------------------------------EDVFDV------------WFDSG 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 578 WYYLRYCdpvnHNRFVGVDAERYWmtgtveqpaGAKVRPGGVDLYVGgtehavlhllYARFWHKVLFDLGYVStpePFQR 657
Cdd:cd00668 206 IGPLGSL----GYPEEKEWFKDSY---------PADWHLIGKDILRG----------WANFWITMLVALFGEI---PPKN 259
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 494040520 658 LVNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQTKPW 710
Cdd:cd00668 260 LLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
44-155 |
8.26e-14 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 73.33 E-value: 8.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 44 KYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQL 123
Cdd:cd00814 1 KVLITTALPYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLF 79
|
90 100 110
....*....|....*....|....*....|..
gi 494040520 124 KKIGFAYDwqREVNTTDPGYYCWTQWIFLRLY 155
Cdd:cd00814 80 KWLNISFD--YFIRTTSPRHKEIVQEFFKKLY 109
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
45-295 |
2.76e-13 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 72.71 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 45 YYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQLK 124
Cdd:pfam09334 1 ILVTTALPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 125 KIGFAYD-WQRevnTTDPGYYCWTQWIFLRLYHSYFdpflqksrpISLLEDALADEPKrTDEWKDDDYLAGLRAHSGDlp 203
Cdd:pfam09334 80 KFNISFDdYGR---TTSERHHELVQEFFLKLYENGY---------IYEKEIEQFYCPS-DERFLPDRYVEGTCPHCGS-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 204 pERRRAVReaiidhhrlayvseapvnwCPALGTVLANEEVIDGKSEVGGHPVERRPMRQWMLRITTYAQRLID--ELDGL 281
Cdd:pfam09334 145 -EDARGDQ-------------------CENCGRHLEPTELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREwiEENNP 204
|
250
....*....|....
gi 494040520 282 DWPESIKLLQRNWI 295
Cdd:pfam09334 205 EWPENVKNMVLEWL 218
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-859 |
7.32e-13 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 72.62 E-value: 7.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 1 MSTERRRPYPYDQIEPKWQERWESARTFHApnpgdpgfDPARPKYYVLDMFPYPSGAG-LHVGHPEGYTATDIIGRYKKM 79
Cdd:PLN02381 92 LSSQMAKQYSPSAVEKSWYAWWEKSGYFGA--------DAKSSKPPFVIVLPPPNVTGaLHIGHALTAAIEDTIIRWKRM 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 80 RGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFR-----------------TQLKKIGFAYDWQREvnttdpg 142
Cdd:PLN02381 164 SGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEfvsevwkwkdeyggtilNQLRRLGASLDWSRE------- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 143 yyCWTQwiflrlyhsyfdpflqksrpislledalaDEPkrtdewkdddylaglrahsgdlppeRRRAVREAIIDHHR--L 220
Cdd:PLN02381 237 --CFTM-----------------------------DEQ-------------------------RSKAVTEAFVRLYKegL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 221 AYVSEAPVNWCPALGTVLANEEV--IDGKSEVgghpverrpmrqwMLRITTYAQrlideldgldwPESIKLLqrnwigrs 298
Cdd:PLN02381 261 IYRDIRLVNWDCTLRTAISDVEVdyIDIKERT-------------LLKVPGYDK-----------PVEFGVL-------- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 299 egAEVQFTVAGSEEKITVFTTRPDTLYGATYMVLAPEHPlverivteeqagaveeykektaRKSDLErtelskektgvwt 378
Cdd:PLN02381 309 --TSFAYPLEGGLGEIVVATTRIETMLGDTAIAIHPDDE----------------------RYKHLH------------- 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 379 GAFAINPVNVERIPIwIADYVLL--GYGTGAIMAVPAHDERDWEFARKYALPIREVVSDTPTLGLGGGSSpcqaeplevf 456
Cdd:PLN02381 352 GKFAVHPFNGRKLPI-ICDAILVdpNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSE---------- 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 457 vgegyaihsgpLDGLSTADAKVEIVRQLTGRGLARKTINYKL-------------------------------------- 498
Cdd:PLN02381 421 -----------FAGMPRFAAREAVIEALQKKGLYRGAKNNEMrlglcsrtndvvepmikpqwfvncssmakqaldaaidg 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 499 -----------------------RDWLFSRQRYWGEPFP---IVWEDGKHRALPDTHlpvnppplDDFKPTGTGEPPLAK 552
Cdd:PLN02381 490 enkklefipkqylaewkrwleniRDWCISRQLWWGHRIPawyVTLEDDQLKELGSYN--------DHWVVARNESDALLE 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 553 ATQwvRYSDKA---TRETNTMPQWAGSCWY---YLRYCDPVNhnrfvgvDAERYWMTGTVEqpagakvrpggvdlyvggT 626
Cdd:PLN02381 562 ASQ--KFPGKKfelSQDPDVLDTWFSSGLFplsVLGWPDDTD-------DLKAFYPTSVLE------------------T 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 627 EHAVLHllyarFWHKVLFDLGYVSTPE-PFQRLVNQGIILGEDGQKMSKSRGNVVNPDDV-------------------- 685
Cdd:PLN02381 615 GHDILF-----FWVARMVMMGMQLGGDvPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVingisleglhkrleegnldp 689
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 686 -----------------ITEYGADALRCYEMFMGPLEQTKPWSMAGVEGVARFLARVW---RLAVEENQAGewvlSSALQ 745
Cdd:PLN02381 690 kelvvakegqkkdfpngIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWnavRFAMSKLGDD----YTPPA 765
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 746 DIEPD------KAQLKVIHATIKKVGEDIESLGFNTAISQMM---------IFVNT----FTNANPRPRKA--------- 797
Cdd:PLN02381 766 TLSVEtmpfscKWILSVLNKAISKTVSSLDAYEFSDAASTVYswwqyqfcdVFIEAikpyFAGDNPEFASEraaaqdtlw 845
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494040520 798 --LRSLLQVLNPFAPHLTEELWERLGFDENGAK---------PLATEPWPAYDaallVEDEIEIVLQVNGKVR 859
Cdd:PLN02381 846 icLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRkdsimiseyPSAVEAWTNEK----VEYEMDLVLSTVKCLR 914
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
499-820 |
7.78e-12 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 69.37 E-value: 7.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 499 RDWLFSRQRYWGEPFPIvW--EDGK----------------------HRALPDtHLPVnppPlddfKPTGTGEPPLAKAT 554
Cdd:PLN02882 465 RDWAVSRSRFWGTPLPI-WisDDGEevvvigsiaeleklsgvkvtdlHRHFID-HITI---P----SSRGPEFGVLRRVD 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 555 Q----WVrysdkatrETNTMPqwagscWYYLRYcdPV-NHNRF----------VGVDAERYWMtgtveqpagakvrpggV 619
Cdd:PLN02882 536 DvfdcWF--------ESGSMP------YAYIHY--PFeNKELFeknfpadfvaEGLDQTRGWF----------------Y 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 620 DLYVGGTehavlhllyarfwhkVLFDlgyvstpEP-FQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCYe 698
Cdd:PLN02882 584 TLMVLST---------------ALFD-------KPaFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLY- 640
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 699 MFMGPLEQTKP--WSMAGVEGVA-----------RFLAR-VWRLAVEEnqagewvlSSALQDIEPDKAQLKV------IH 758
Cdd:PLN02882 641 LINSPVVRAEPlrFKEEGVFGVVkdvflpwynayRFLVQnAKRLEVEG--------GAPFVPLDLAKLQNSAnvldrwIN 712
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 759 AT----IKKVGEDIESLGFNTAISQMMIFVNTFTNANPR--------------PRKALRSLLQVL-------NPFAPHLT 813
Cdd:PLN02882 713 SAtqslVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRfnrkrlkgrtgeedCRTALSTLYNVLltsckvmAPFTPFFT 792
|
....*..
gi 494040520 814 EELWERL 820
Cdd:PLN02882 793 EVLYQNL 799
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
629-894 |
7.85e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 69.06 E-value: 7.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 629 AVLHLL-------YARFWHKVLFDLGYvstpEPFQRLVNQGIILGEDGqKMSKSRGNVVNPDDVITEYGADALRCY---E 698
Cdd:PRK12267 255 ADVHLVgkdilrfHAIYWPIMLMALGL----PLPKKVFAHGWWLMKDG-KMSKSKGNVVDPEELVDRYGLDALRYYllrE 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 699 MfmgpleqtkPWSMAGV---EG-VARF-----------LARVwrLA-VEENQAGEWVLSSALQDIepDKAQLKVIHATIK 762
Cdd:PRK12267 330 V---------PFGSDGDfspEAlVERInsdlandlgnlLNRT--VAmINKYFDGEIPAPGNVTEF--DEELIALAEETLK 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 763 KVGEDIESLGFNTAISQMMIFVnTFTN--------------ANPRPRKA------LRSLLQV---LNPFAPHLTEELWER 819
Cdd:PRK12267 397 NYEELMEELQFSRALEEVWKLI-SRANkyidetapwvlakdEGKKERLAtvmyhlAESLRKVavlLSPFMPETSKKIFEQ 475
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494040520 820 LGFDENGAKPLATEPWPAYDAALLVEdEIEIVLQvngkvrdKIIVkkeasKEEVEAAARASSKIAEWTAGKEIKK 894
Cdd:PRK12267 476 LGLEEELTSWESLLEWGGLPAGTKVA-KGEPLFP-------RIDV-----EEEIAYIKEQMEGSAPKEPEEKEKK 537
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
44-155 |
1.34e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 67.98 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 44 KYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQL 123
Cdd:PRK11893 2 KFYITTPIYYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLW 80
|
90 100 110
....*....|....*....|....*....|..
gi 494040520 124 KKIGFAYDwqREVNTTDPGYYCWTQWIFLRLY 155
Cdd:PRK11893 81 EALNISYD--DFIRTTDPRHKEAVQEIFQRLL 110
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
43-155 |
5.60e-10 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 61.86 E-value: 5.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 43 PKYYVLDMFPYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVG--RFR 120
Cdd:cd00818 1 PEFVFHDGPPYANGL-PHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGiaEFN 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 494040520 121 TQLKKIGFAY---------------DWQREVNTTDPGYYCWTQWIFLRLY 155
Cdd:cd00818 80 AKCREFALRYvdeqeeqfqrlgvwvDWENPYKTMDPEYMESVWWVFKQLH 129
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
628-706 |
2.76e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.47 E-value: 2.76e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494040520 628 HAVlhllyarFWHKVLFDLGYvstpEPFQRLVNQGIILGEdGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQ 706
Cdd:cd00814 249 HAI-------YWPAMLLGAGL----PLPTRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGK 315
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
668-896 |
1.17e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 59.01 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 668 DGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPlEQTK----PWS---------MAGVEG-----VARFLARvwrla 729
Cdd:PRK00133 326 EGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLP-ETIDdldfNWEdfqqrvnseLVGKVVnfasrTAGFINK----- 399
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 730 veeNQAGEwvlssaLQDIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMM---IFVNTFTNAN-P-----RPRKAL-- 798
Cdd:PRK00133 400 ---RFDGK------LPDALADPELLEEFEAAAEKIAEAYEAREFRKALREIMalaDFANKYVDDNePwklakQDGERLqa 470
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 799 ---------RSLLQVLNPFAPHLTEELWERLGFD----ENGAKPLATEPWPAYdaallvedeiEIVLQvngKVRDKIIVK 865
Cdd:PRK00133 471 vcsvglnlfRALAIYLKPVLPELAERAEAFLNLEeltwDDAQQPLAGHPINKF----------KILFT---RIEDKQIEA 537
|
250 260 270
....*....|....*....|....*....|..
gi 494040520 866 -KEASKEEvEAAARASSKIAEWTAGKEIKKVV 896
Cdd:PRK00133 538 lIEASKEA-AAAKAAAAAAAAPLAEEPIAETI 568
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
499-697 |
9.42e-08 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 56.13 E-value: 9.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 499 RDWLFSRQRYWGEPFPIvWEDGK-------------------------HRALPDtHLPVNPPPLDDFkptgtgePPLAKA 553
Cdd:PTZ00427 569 KDWCISRNRYWGTPIPI-WADEKmetvicvesikhleelsgvknindlHRHFID-HIEIKNPKGKTY-------PKLKRI 639
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 554 TQ----WVrysdkatrETNTMPqwagscwyYLRYCDPVN------HNRFV------GVDAERYWMtgtveqpagakvrpg 617
Cdd:PTZ00427 640 PEvfdcWF--------ESGSMP--------YAKVHYPFStekedfHKIFPadfiaeGLDQTRGWF--------------- 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 618 gVDLYVGGTehavlhllyarfwhkVLFDLGyvstpePFQRLVNQGIILGEDGQKMSKSRGNVVNPDDVITEYGADALRCY 697
Cdd:PTZ00427 689 -YTLLVIST---------------LLFDKA------PFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLY 746
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
1-103 |
2.22e-07 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 55.08 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 1 MSTERRrpypyDQ---IEPKWQERWESARTFHApnpgDPGFDPARP--KYYVldMFPYPSGAG-LHVGHPEGYTATDIIG 74
Cdd:PLN02959 7 KSTARR-----DRlleIEVAVQKWWEEEKVFEA----EAGDEPPKPgeKFFG--NFPYPYMNGlLHLGHAFSLSKLEFAA 75
|
90 100
....*....|....*....|....*....
gi 494040520 75 RYKKMRGCNVLHPMGWDAFGLPAEQYAIK 103
Cdd:PLN02959 76 AYHRLRGANVLLPFAFHCTGMPIKASADK 104
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
710-820 |
1.01e-06 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 48.36 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 710 WSMAGVEGVARFLARVWRLAVEenQAGEWVLSSALQDIepDKAQLKVIHATIKKVGEDIESLGFNTAIsQMMIFvnTFTN 789
Cdd:cd07959 1 FREEEANSAILRLERFYELAEE--LIETEGELEELTFI--DRWLLSRLNRLIKETTEAYENMQFREAL-KEGLY--ELQN 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 494040520 790 A---------NPRPRKALRSLLQV----LNPFAPHLTEELWERL 820
Cdd:cd07959 74 DldwyrerggAGMNKDLLRRFIEVwtrlLAPFAPHLAEEIWHEL 117
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
668-854 |
1.56e-06 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 51.64 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 668 DGQKMSKSRGNVVNPDDVITEYGADALRcyeMFMG------PLEqtkpWSMAGVEGVARFLARvwrlaveenqagewvLS 741
Cdd:COG0215 262 NGEKMSKSLGNFFTVRDLLKKYDPEVLR---FFLLsahyrsPLD----FSEEALEEAEKALER---------------LY 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 742 SALQDIEPDKAQLKVIHATIKKVGED-IESLG--FNT--AISQMMIFV---NTFTNANPrPRKALRSLLQVLnpfaphlt 813
Cdd:COG0215 320 NALRRLEEALGAADSSAEEIEELREEfIAAMDddFNTpeALAVLFELVreiNKALDEGE-DKAALAALAALL-------- 390
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 494040520 814 EELWERLGFDengakPLATEPWPAYDAALLVEDEIEIVLQV 854
Cdd:COG0215 391 RALGGVLGLL-----LLEPEAWQGAAEDELLDALIEALIEE 426
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
638-706 |
3.16e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 50.37 E-value: 3.16e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494040520 638 FWHKVLFDLGYvstPEPFQRLVNQGIILgeDGQKMSKSRGNVVNPDDVITEYGADALRCYEMFMGPLEQ 706
Cdd:pfam09334 296 FWPAMLLGAGY---RLPTTVFAHGYLTY--EGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETK 359
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
53-155 |
3.53e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 50.95 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 53 YPSGAgLHVGHpeGYT--ATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGQHPSVTTAENVGRFRTQLKKIGFAY 130
Cdd:PRK12267 14 YPNGK-PHIGH--AYTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLDISY 90
|
90 100
....*....|....*....|....*.
gi 494040520 131 DwqREVNTTDPgYYCWT-QWIFLRLY 155
Cdd:PRK12267 91 D--KFIRTTDE-RHKKVvQKIFEKLY 113
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
738-854 |
4.05e-05 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 45.23 E-value: 4.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 738 WVLSSalqdiepdkaqlkvIHATIKKVGEDIESLGFNTAISQMMIFVNTFTN----ANpRPR------------------ 795
Cdd:cd07961 51 WILSR--------------LNSLIKEVTEEMEAYDLYTAVRALLEFIDELTNwyirRN-RKRfwgeegdddklaayatly 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494040520 796 KALRSLLQVLNPFAPHLTEELWERLgfdeNGAKPLATE-----PWPAYDAALL---VEDEIEIVLQV 854
Cdd:cd07961 116 EVLLTLSRLMAPFTPFITEEIYQNL----RRELGDAPEsvhllDWPEVDESLIdeeLEEAMELVREI 178
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
798-858 |
1.69e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 43.28 E-value: 1.69e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494040520 798 LRSLLQVLNPFAPHLTEELWERLGFdENGAKPLATEPWPAYDAALL---VEDEIEIVLQVNGKV 858
Cdd:cd07960 117 LDALLKLLAPILPFTAEEVWEHLPG-EKKEESVFLEDWPELPEEWKdeeLEEKWEKLLALRDEV 179
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
52-155 |
1.92e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 45.14 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 52 PYPSGAgLHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQYAIKTGqhpsVTTAENVGRFRTQLKKI----G 127
Cdd:PRK00133 11 PYANGP-IHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEG----ITPEELIARYHAEHKRDfagfG 85
|
90 100
....*....|....*....|....*....
gi 494040520 128 FAYD-WQRevnTTDPGYYCWTQWIFLRLY 155
Cdd:PRK00133 86 ISFDnYGS---THSEENRELAQEIYLKLK 111
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
750-820 |
2.77e-04 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 41.77 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 750 DKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFV-NTF------------TNANPRPRKA--------LRSLLQVLNPF 808
Cdd:cd07962 44 DRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFcdwylelvkprlYGEDEEEKKAaratlyyvLETILRLLHPF 123
|
90
....*....|..
gi 494040520 809 APHLTEELWERL 820
Cdd:cd07962 124 MPFITEELWQRL 135
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
668-695 |
6.35e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 42.18 E-value: 6.35e-04
10 20
....*....|....*....|....*...
gi 494040520 668 DGQKMSKSRGNVVNPDDVITEYGADALR 695
Cdd:cd00672 171 DGEKMSKSLGNFITVRDALKKYDPEVLR 198
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
746-820 |
1.08e-03 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 39.78 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 746 DIEPDKAQLKVIHATIKKVGEDIESLGFNTAISQMMIFV---NTFTNAN-----------PRPRKALRSLLQV------- 804
Cdd:cd07957 34 LTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELAraaNKYIDETapwklakeedpERLATVLYVLLELlrilail 113
|
90
....*....|....*.
gi 494040520 805 LNPFAPHLTEELWERL 820
Cdd:cd07957 114 LSPFMPETAEKILDQL 129
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
42-99 |
1.68e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 42.40 E-value: 1.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 494040520 42 RPKYYVLDMFPYPSGAGlHVGHPEGYTATDIIGRYKKMRGCNVLHPMGWDAFGLPAEQ 99
Cdd:PLN02882 37 LPEYIFYDGPPFATGLP-HYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEY 93
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
664-703 |
4.32e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 40.57 E-value: 4.32e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 494040520 664 ILGEDGQKMSKSRGNVVNPDDVITEYGADALRCYeMFMGP 703
Cdd:PRK00750 273 FLDKKGEKISKSKGNVITIEDWLEYAPPESLRLF-MFARP 311
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
557-687 |
7.78e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 39.79 E-value: 7.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 557 VRYSDKATRETNTMPQWAGSC-----------WYYLrycdpvnhnrfvGVDAErywmtgtveqpagakvrPGGVDLYVGG 625
Cdd:COG1384 205 VTYRCEGCGHEGETPVTGGNGklqwkvdwamrWAAL------------GVDFE-----------------PFGKDHAAGS 255
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494040520 626 TEhavlhlLYARFWHKVLfdlGYVStPEPFqrlvNQGIILGEDGQKMSKSRGNVVNPDDVIT 687
Cdd:COG1384 256 VD------SGSKIAREVL---GGEP-PEGF----VYELFLDENGEKISKSKGNGLTVEEWLE 303
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
621-688 |
9.77e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 39.37 E-value: 9.77e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494040520 621 LYVGGTEHavlHLLYARFWhKVLFDLGYVstPEPFQRLVNQ--GIILGEDGQKMSKSRGNVVNPDDVITE 688
Cdd:PRK01611 276 IYVVGADH---HGHFKRLK-AALKALGYD--PDALEVLLHQmvGLVRGGEGVKMSTRAGNVVTLDDLLDE 339
|
|
| |
