|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
8-412 |
6.38e-95 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 290.28 E-value: 6.38e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 8 RWTSAIIPALLIHIPIGTVYCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEKN-IKKSALVSMVCFVV 86
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGgPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 87 GFAGTGVSIALnflPGVFICYGAIMGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLV 166
Cdd:cd17353 81 GFILSAFAISL---PLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 167 SMFFILAAVYAVMMFVGFLLIKRPAGWVYDPATS-----------HVSRKTILKKPVFWGIWIAFYINITCGLALISQEK 235
Cdd:cd17353 158 TTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDplannaensprDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 236 DILHDvlrafpqyanlspakFAAAISGIIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETvYQVIFIMSIAVCLLQIFTNS 315
Cdd:cd17353 238 PIGQE---------------FAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT-LSIAFLIQGVAMFLLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 316 IgnalLWAVLAMLFLVNAGYGGGFSTLPVLLDQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVvahapDQAHRYAALI 395
Cdd:cd17353 302 V----AVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV-----LYTGGYNAAF 372
|
410
....*....|....*..
gi 494110956 396 PVLTGLFVVALISISLV 412
Cdd:cd17353 373 IIAAALSLVALALALLL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-413 |
6.02e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 157.74 E-value: 6.02e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 7 NRWTSAIIPALLIHIPIGTVYCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEKN-IKKSALVSMVCFV 85
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFgPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 86 VGFAGTGVSIALnflpGVFICYGAIMGIGLGVGYLTPVKNLMLWF-ADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVG 164
Cdd:COG2223 82 IGLLLLALAVSY----WLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 165 LVSMFFILAAVYAVMMFVGFLLIKR-PAGWVYDPATSHVSRKTILKKPVFWGIWIAFYINITCGLALISQEKDILHDVLR 243
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDpPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 244 AFPQYAnlspakfaaaisgiiGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNSignalLWA 323
Cdd:COG2223 238 LSAATA---------------GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS-----LWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 324 VLAMLFLVNAGYGGGFSTLPVLLDQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVahapDQAHRYAALIPVLTGLFV 403
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL----DATGSYTAAFLVFAVLAL 373
|
410
....*....|
gi 494110956 404 VALISISLVK 413
Cdd:COG2223 374 VALVLTLLLY 383
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-373 |
1.84e-18 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 86.70 E-value: 1.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 8 RWTSAIIPALLIHIPIGTVYCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEK-NIKKSALVSMVCFVV 86
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSfGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 87 GFagTGVSIALNFLPGVFICYgAIMGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLV 166
Cdd:cd17314 81 GY--TYLSYVFNSFPLSYACF-VFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 167 SMFFIL-AAVYAVMMFVGFLLIKRPA---GWVYDPATSHVSRKTILKKPVFWGIWIAFYINITCGLALISQEKDilhdvl 242
Cdd:cd17314 158 LVYTILgILAAIVLSVVSLLGFKEPPdnqARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMAS------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 243 rafpqYANLSPAKfaaaISGIIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIF-IMSIAVCLLQIFTNSIGnall 321
Cdd:cd17314 232 -----LVRSLQLD----APSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLtILGLGLCAFLFLLKMTP---- 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 494110956 322 WAVLAMLFLVNAGYGGGFSTLPVLLDQHFGTKTVSTTHGLTLSAWAFAGLSG 373
Cdd:cd17314 299 VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILG 350
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
16-412 |
9.96e-18 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 84.14 E-value: 9.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 16 ALLIHIPI-GTVYCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVekNIKKSALVSMVCFVVGFAGTGVS 94
Cdd:cd17352 8 SFLVNFFTdGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALV--NRFGCRPVAIAGGLLAALGLLLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 95 IALNFLPGVFICYGAIMGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAA 174
Cdd:cd17352 86 SFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 175 VYAVMMFVGFLLIkrpagwvydpatshvsrktILKKPVFW----GIWIAFYINITCGLALISQEKDILHDVLRAFpqyan 250
Cdd:cd17352 166 LCLNLCVCGLLLR-------------------LLKDPTFVllalGVSFAMLGFFVPFVYLPSYAKSLGIDESDAA----- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 251 lspakfaaaisgiigLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNSIgnalLWAVLAMLFL 330
Cdd:cd17352 222 ---------------FLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATT----YVGLIVFSVL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 331 VNAGYGGGFSTLPVLLDQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVahapDQAHRYAALIPVLTGLFVVALISIS 410
Cdd:cd17352 283 FGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLR----DYTGDYDAAFYFCGACLLLSGVLLF 358
|
..
gi 494110956 411 LV 412
Cdd:cd17352 359 LL 360
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
8-360 |
1.50e-16 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 80.76 E-value: 1.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 8 RWTSAIIpALLIHIPIGTVYCWSVFKQLIADRLHASPASVEWGFSLAI------FFLGMSAAFAGPMVeknikkSALVSM 81
Cdd:cd17354 2 RWLSFVA-ALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDlgylvgPLLGLLSDRLGPWL------LLLIGA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 82 VCFVVGFAGTGVSIALNF----LPGVFICYGAImGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLME 157
Cdd:cd17354 75 ILFFPGYGVLWLVVTGLIsdlsFWLMCLCFFLI-GNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQLYK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 158 YLIGTvGLVSMFFILAAVYAVMMFVGFLLIKrpagwVYDPATShvsrkTILKKPVFWGIWIAFYINITCGLALIsqekdi 237
Cdd:cd17354 154 ALFFH-DSARVFLFLAVLPAVVGLLAWFSVR-----IVSIEEG-----EFLKDIDFWLLFISLFLGVGPGEMFI------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 238 lhdvlrafpqyANLSPAKFAAAISGIIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIF------IMSIAVCllqI 311
Cdd:cd17354 217 -----------NNLGQIGQSLTGPSNTSTLVSLFSIFSFLGRLLSGLLSDLFVRKFRLPRPSRmvllllILSLGHL---L 282
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 494110956 312 FTNSIGNALLWAVLAmlfLVNAGYGGGFSTLPVLLDQHFGTKTVSTTHG 360
Cdd:cd17354 283 QAFGLPSGALYVASA---LIGFGYGGLFSIAPTIVSELFGLKNFGTNYG 328
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
36-407 |
6.32e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.98 E-value: 6.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 36 IADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEK-NIKKSALVSMVCFVVGFAGTGVSIALnflPGVFICYgAIMGIG 114
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRfGLERTLLLALLLLAAGLLLRSLAPSV---ALLLAGT-ALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 115 LGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFVGFLLIKRPAGwV 194
Cdd:COG2807 120 IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA-A 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 195 YDPATSHVSRKTILKKPVFWGIWIAFYINITCGLALISQEKDILHDvlrafpqyANLSPAKfaaaisgiIGLVLAVDSVF 274
Cdd:COG2807 199 AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD--------AGLSAAT--------AGLLLSLFQLA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 275 NTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNSIGnALLWAVLAMLflvnaGYGGGFSTLPVLLDQHFGTKT 354
Cdd:COG2807 263 GIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSL-PWLWAVLLGL-----GQGGLFPLALTLIGLRARTPA 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 494110956 355 VSTthglTLSAWAF-AGLSGNQLASFVVAHAPDQAHRYAALIPVLTGLFVVALI 407
Cdd:COG2807 337 EAA----ALSGMAQsVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-370 |
1.64e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.16 E-value: 1.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 1 MARFTENRWTSAIIPALLIHIPIGTVYCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEK-NIKKSALV 79
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRfGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 80 SMVCFVVGFAGTGVSIALnflpGVFICYGAIMGIGLGVGYLTPVKNLMLWF-ADNKGLATGIAVAGFGLAKAIASPLMEY 158
Cdd:COG2814 81 GLLLFALGSLLCALAPSL----WLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 159 LIGTVGLVSMFFILAAVYAVMMFVGFLLIKRPAgwVYDPATSHVSRKTILKKPVFWGIWIAFYINITCGLALISQEKDIL 238
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESR--PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 239 HDVLrafpqyaNLSPAkfaaaisgIIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNsign 318
Cdd:COG2814 235 QEVL-------GLSAS--------AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS---- 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 494110956 319 alLWAVLAMLFLVNAGYGGGFSTLPVLLDQHFGTKTVSTTHGLTLSAWAFAG 370
Cdd:COG2814 296 --LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-413 |
8.63e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.13 E-value: 8.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 27 YCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEK-NIKKSALVSMVCFVVGFAGTGVSIALNFLPGVFI 105
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRfGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 106 cygaIMGIGLGVGYLTPVKNLMLWFADNK-GLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFVGF 184
Cdd:COG2271 107 ----LLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 185 llikrpagwvydpatshvsrktilkkpvfWGIWIAFYINITCGLALISQEKDILHDVLrafpqyaNLSPAKfaaaisgiI 264
Cdd:COG2271 183 -----------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVR-------GLSLAQ--------A 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 265 GLVLAVDSVFNTAGRVGFSTLSDHLKRRE-TVYQVIFIMSIAVCLLQIFTNSignalLWAVLAMLFLVNAGYGGGFSTLP 343
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPS-----PALAIALLFLAGFGLGGAFGLLW 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 344 VLLDQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVahapdQAHRYAALIPVLTGLFVVALISISLVK 413
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL-----DATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-407 |
2.67e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.68 E-value: 2.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 9 WTSAIIPALLIHIPIGTVYCWSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEK-NIKKSALVSMVCFVVG 87
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRfGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 88 FAGTGVSialNFLPGVFICYGAIMGIGLGVGYLTPVKNLMLW-FADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLV 166
Cdd:cd17355 82 LVLLALA---TSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 167 SMFFILAAVYAVMMF-VGFLLIKRPAG------WVYDPATSHVSRKTILKKPVFWGIWIAFyinITCGLALisqekdilh 239
Cdd:cd17355 159 TALLVLALLALLVLVpVLLLLRRRPADlalrayDDASPASPGSTLKEALRSASFWLLALAF---FLCGFAV--------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 240 dvlrAFPQYANLSPAKFAAAISGIIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNSIGNA 319
Cdd:cd17355 227 ----VGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLAL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 320 LLWAVlamlfLVNAGYGGGFSTLPVLLDQHFGTKTVSTTHGLTlsawAFAGLSGNQLASFVVAHAPDQAHRYAALIPVLT 399
Cdd:cd17355 303 LLFAA-----LFGLGWGATVPLTAALAARYFGARSYGTLFGLV----FAPHQLGSALGPWLGGLLYDRTGSYTAAWALAV 373
|
....*...
gi 494110956 400 GLFVVALI 407
Cdd:cd17355 374 ALGLIAAL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-373 |
3.30e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 64.36 E-value: 3.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 29 WSVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEKNIKKSAlvsMVCFVVGFAGTGVSIALNFLPGVFICYG 108
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV---LLIGLLLFALGLLLLLFASSLWLLLVLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 109 AIMGIGLGVGYLTPVKNLMLWFAD-NKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFVGFLLI 187
Cdd:pfam07690 93 VLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 188 KRPAGWVYDPATS-----HVSRKTILKKPVFWGIWIAFYINITCGLALIsqekdilhdVLRAFPQYANLSPAkfaaaisg 262
Cdd:pfam07690 173 PPPESKRPKPAEEarlslIVAWKALLRDPVLWLLLALLLFGFAFFGLLT---------YLPLYQEVLGLSAL-------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 263 IIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNSIGNALLWAVlamLFLVNAGYGGGFSTL 342
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA---LLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|.
gi 494110956 343 PVLLDQHFGTKTVSTTHGLTLSAWAFAGLSG 373
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-409 |
4.21e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 4.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 29 WSVFKQLIADRLHASPASVEWGFSlaIFFLGMSAA--FAGPMVEK-NIKKSALVSMVCFVVgfagtgVSIALNFLPGVFI 105
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIAS--AFFLGYALFqvPGGWLLDRfGARKVLAVSMLLWSL------FTALTGFATSLTS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 106 CYGAIMGIGLGVGYLTPVKNLML--WF-ADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFV 182
Cdd:cd17319 94 LYVLRFLLGVAEAGFFPGAIKALaeWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 183 GFLLIKRpagwvydpatshvsrktilkkpvFWGIWIAFYINITCGLALISQEKDILHDVLrafpqyaNLSPAKfaaaisg 262
Cdd:cd17319 174 WWFYLRQ-----------------------VWGLALGYFGINYALYGLLTWLPTYLKQAR-------GFSLKQ------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 263 iIGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIM---SIAVCLLQIFTNsignalLWAVLAMLFLVNAGYGGGF 339
Cdd:cd17319 217 -VGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLllaAVGLLLAYLTTS------PVVAVILLSLAGFGIGAAS 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 340 STLPVLLDQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVahapDQAHRYAALIPVLTGLFVVALISI 409
Cdd:cd17319 290 PVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV----DATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
35-408 |
1.38e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.80 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 35 LIADRLHASPAsvEWGFSLAIFFLGMSAA--FAGPMVEK-NIKKSALVSMVCFVVgfagtgVSIALNFLPGVFICYGAIM 111
Cdd:cd17325 21 LYAESLGASVA--QIGLIVAAYALAQLLFspPAGRLSDRfGRKRLLLLGLLLLAV------STLLFAFATSYWQLLLARF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 112 GIGLGVGYLTPVKNLML---WFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFVGFLLIK 188
Cdd:cd17325 93 LQGLASAAVWPAAMALIadiAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 189 RPAGWVYDPATSHVSRKTILKKPVFWG-IWIAFYINITCGLALISQEKdilhdvlrAFPQYAnlspAKFAAAISGIIGLV 267
Cdd:cd17325 173 EPRPPPNKRAVSAARLRSGLRLLLRDRrLLALFLAIFVLAFAFGALEP--------FLPLYA----AELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 268 LAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNsignalLWAVLAMLFLVNAGYGGGFSTLPVLLD 347
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS------FWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494110956 348 QHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVAHAPDQAHRYAALIPVLTGLFVVALIS 408
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
103-379 |
2.67e-04 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 42.76 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 103 VFICYGAIMGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFV 182
Cdd:cd17423 94 LYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLVPC 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 183 GFLLikRPAGWVYDPATSHVSRKTILKKPVF--WGiwiafYINITCGLALISQEKDILHDVLRAFPQYANLSPAKFAaai 260
Cdd:cd17423 174 GALL--RPLALPGDPPAPPRSLSAAFGLSLLthRA-----FLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAA--- 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 261 sgiigLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTNSIGNALLWAVLAMLFLVNAGYGGGFS 340
Cdd:cd17423 244 -----FVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFS 318
|
250 260 270
....*....|....*....|....*....|....*....
gi 494110956 341 TLPVLLdqhfGTKTVSTTHGLTLSAWAFAGLSGNQLASF 379
Cdd:cd17423 319 VLPELV----GVERVLNATGLLQMIESVGGLLGPPLSGW 353
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
85-330 |
7.60e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 7.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 85 VVGFAGTGVSIALNFLPGVFICYGAIM-GIGLGVGYLTPV--KNLMLWFADN-KGLATGIAVAGFGLAKAIASPLMEYLI 160
Cdd:cd17475 65 AVGLLLMGAAALLMALVGSYPVLLVLLfLVGAGYGSVQPGggRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 161 GTVGLVSMFFILAAVYAVMMFVGFLLIKRPAGWVYDPATSHVSRKTILKKPVFWGIW-IAFYInitcglalisqekdilh 239
Cdd:cd17475 145 LHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWlIAIAG----------------- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 240 dVLRAFPQYANLSPAK-FAAAISGI----IGLVLAVDSVFNTAGRVGFSTLSDHLKRRETVYQVIFIMSIAVCLLQIFTN 314
Cdd:cd17475 208 -ALLVAPQFALLTFLLlFLHDHLGLsvvaAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSL 286
|
250
....*....|....*.
gi 494110956 315 SIGNALLWAVLAMLFL 330
Cdd:cd17475 287 LSPGTPLWLLVLLLIL 302
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
36-413 |
1.35e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 36 IADRLHASPAsvEWGFSLAIFFLGM--SAAFAGPMVEK-NIKKSALVSMVCFVVGFAGTGvsialnFLPGVFICYGAIMG 112
Cdd:COG0738 34 LKDAFGLSDA--QAGLLLFAFFLGYllASLPAGRLIDRfGYKRGLLLGLLLMALGLLLFA------LAPSYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 113 IGLGVGYLTPVKN--LMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIG---TVGLVSMFFILAAVYAVMMFVGFLL- 186
Cdd:COG0738 106 LGLGLGLLDVAANpyVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSk 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 187 IKRPAGWVYDPATSHVSRKTILKKPVFWGIWIAFYINITCGLALISQEKDILHDVLRAFPQYANLSPAKFAAAIsgiigl 266
Cdd:COG0738 186 LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGM------ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 267 vlavdsvfnTAGRVGFSTLSDHLKRReTVYQVIFIMSIAVCLLQIFTNSignalLWAVLAMLFLVNAGYGGGFSTLpvll 346
Cdd:COG0738 260 ---------TIGRFLGGFLLKRFGPV-RLLRLSALLAAVGLLLALLAPG-----PWLALIGLALVGLGLSLMFPTI---- 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494110956 347 dQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVAHAPDQAHRYAALIPVLTGLFVVALISISLVK 413
Cdd:COG0738 321 -FSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
38-191 |
1.39e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 38 DRLHASPASVewGFSLAIFFLGMSAA-FAGPMVEKNIKKSALVsMVCFVVGFAGTGVSIalnFLPGVFICYGAIMGIGLG 116
Cdd:COG0738 239 DVLGLSEATA--ALGLSLFWGGMTIGrFLGGFLLKRFGPVRLL-RLSALLAAVGLLLAL---LAPGPWLALIGLALVGLG 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494110956 117 VGYLTPVknLMLWFADNKGLATGIAVAGF----GLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFVGFLLIKRPA 191
Cdd:COG0738 313 LSLMFPT--IFSLALDGLGKRTAAAVSAVlimgIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
85-184 |
1.67e-03 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 40.59 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 85 VVGFAGTGVSIALNFLPGVFICYGAIMGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVG 164
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
90 100
....*....|....*....|
gi 494110956 165 LVSMFFILAAVYAVMMFVGF 184
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSF 180
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
35-407 |
3.00e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 35 LIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEK-NIKKSALVSMVCFVVGFAGTGVS------IALNFLPGVFIcy 107
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRiERRRLLLVLLLLFILGNLLAALApsfallLLARALAGLAH-- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 108 GAIMGIGLGV-GYLTPvknlmlwfADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAAVYAVMMFVGFLL 186
Cdd:cd17324 102 GGFWAIAAAYaADLVP--------PEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 187 IKRPAGWVYDPATSHVSRKTILKKPVFWGIWIAFYINITCGLALISQEKDILHDVLRAFPQyaNLSPAKFAAAISGIIGL 266
Cdd:cd17324 174 LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS--AIIGLLLLFGVAGVVGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494110956 267 VLAvdsvfntaGRvgfstLSDHLKRRETVYQVIFIMSIAVCLLQIFTNsignalLWAVLAMLFLVNAGYGGGFSTLPVLL 346
Cdd:cd17324 252 PLA--------GR-----LADRGGRRALLIALLLLAAALLLLTLLGPS------PLLLLVGLVLWGLGFFAAHSALQTRV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494110956 347 dQHFGTKTVSTTHGLTLSAWAFAGLSGNQLASFVVAHAPdqahrYAALIPVLTGLFVVALI 407
Cdd:cd17324 313 -LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG-----WAGVGWVGAALLLLALL 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
21-192 |
5.20e-03 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 38.70 E-value: 5.20e-03
10 20 30 40 50 60 70 80
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gi 494110956 21 IPIGTVYCW----SVFKQLIADRLHASPASVEWGFSLAIFFLGMSAAFAGPMVEKNIKKSALVSMVCFvvgfAGTGVSIA 96
Cdd:cd17426 10 ISIGFSYAFpksiTVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCL----SGAGLIAA 85
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90 100 110 120 130 140 150 160
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gi 494110956 97 --LNFLPGVFICYGAIMGIGLGVGYLTPVKNLMLWFADNKGLATGIAVAGFGLAKAIASPLMEYLIGTVGLVSMFFILAA 174
Cdd:cd17426 86 sfCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFLILGG 165
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170
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gi 494110956 175 VYAVMMFVGFLLikRPAG 192
Cdd:cd17426 166 LLLNCCVAGSLM--RPIG 181
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