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Conserved domains on  [gi|494113220|ref|WP_007053998|]
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MULTISPECIES: MFS transporter [Bifidobacterium]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-479 1.10e-73

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17503:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 380  Bit Score: 237.09  E-value: 1.10e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  22 VGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 102 AQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLV 181
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 182 LIAAcigmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsliaglallivfam 261
Cdd:cd17503  161 ILAL---------------------------------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 262 sskrAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDK 341
Cdd:cd17503  165 ----LLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 342 FGAVKPILIPLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGA 421
Cdd:cd17503  241 FGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGS 320

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 422 AGTALFSTILSVAQA--GAGEEGTAEFAHATAVGGTWTFATMTVICLIGWCCLATAFRIR 479
Cdd:cd17503  321 IGTALLATLLTNRTQfhHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 22-479 1.10e-73

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 237.09  E-value: 1.10e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  22 VGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 102 AQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLV 181
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 182 LIAAcigmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsliaglallivfam 261
Cdd:cd17503  161 ILAL---------------------------------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 262 sskrAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDK 341
Cdd:cd17503  165 ----LLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 342 FGAVKPILIPLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGA 421
Cdd:cd17503  241 FGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGS 320

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 422 AGTALFSTILSVAQA--GAGEEGTAEFAHATAVGGTWTFATMTVICLIGWCCLATAFRIR 479
Cdd:cd17503  321 IGTALLATLLTNRTQfhHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 27-432 3.87e-45

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 164.47  E-value: 3.87e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   27 FIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFP 106
Cdd:TIGR00711  12 FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  107 LLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAAC 186
Cdd:TIGR00711  92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  187 IGMKCIEQKTPTEAAYLDPIQLGSIVVALVGLVLALNQGgvaisaavsGKSATRSGIIAIVSLIAGLALLIVFAMSSKRA 266
Cdd:TIGR00711 172 VAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEG---------PERGWFDSNEILILSITGLVAIIAFVVWELTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  267 FSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFGAVK 346
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  347 PILIPLGIAILGPVLMLV-FSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAGTA 425
Cdd:TIGR00711 323 LVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402


                  ....*..
gi 494113220  426 LFSTILS 432
Cdd:TIGR00711 403 LITTILT 409
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-422 1.35e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.06  E-value: 1.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  10 KIPTRLIGAIVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAV 89
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  90 ILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLP 169
Cdd:COG2814   83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 170 WRAIFVIAIPLVLIAAcigmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsl 249
Cdd:COG2814  163 WRWVFLVNAVLALLAL---------------------------------------------------------------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 250 iAGLALLIVFAMSSKRAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGA 329
Cdd:COG2814  179 -LLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 330 VCAPLGGWFYDKFGAVKPILIPLGIAILGpvlMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGN 409
Cdd:COG2814  258 LGALLAGRLADRFGRRRLLLIGLLLLALG---LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334

                        410
                 ....*....|...
gi 494113220 410 AIFNTCLQFGGAA 422
Cdd:COG2814  335 GLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
24-424 3.76e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.41  E-value: 3.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   24 SLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQ 103
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  104 AFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLI 183
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  184 AAcigmkcieqktpteaayldpiqlgsivvalVGLVLALNQGGVAISAAVSGKSATRSGIIAIVSLIAGLALLIVFAMSS 263
Cdd:pfam07690 164 AA------------------------------VLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  264 krafspllrlgilkdpavllhacaylllplVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFG 343
Cdd:pfam07690 214 ------------------------------FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  344 AVKPILIPLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAG 423
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343


                  .
gi 494113220  424 T 424
Cdd:pfam07690 344 P 344
PRK10504 PRK10504
putative transporter; Provisional
 19-185 8.14e-13

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 70.15  E-value: 8.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGslAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:PRK10504  14 IVAFG--FFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAI 178
Cdd:PRK10504  92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171


                 ....*..
gi 494113220 179 PLVLIAA 185
Cdd:PRK10504 172 PVGIIGA 178
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 22-479 1.10e-73

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 237.09  E-value: 1.10e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  22 VGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 102 AQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLV 181
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 182 LIAAcigmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsliaglallivfam 261
Cdd:cd17503  161 ILAL---------------------------------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 262 sskrAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDK 341
Cdd:cd17503  165 ----LLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 342 FGAVKPILIPLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGA 421
Cdd:cd17503  241 FGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGS 320

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 422 AGTALFSTILSVAQA--GAGEEGTAEFAHATAVGGTWTFATMTVICLIGWCCLATAFRIR 479
Cdd:cd17503  321 IGTALLATLLTNRTQfhHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 27-432 3.87e-45

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 164.47  E-value: 3.87e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   27 FIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFP 106
Cdd:TIGR00711  12 FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  107 LLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAAC 186
Cdd:TIGR00711  92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  187 IGMKCIEQKTPTEAAYLDPIQLGSIVVALVGLVLALNQGgvaisaavsGKSATRSGIIAIVSLIAGLALLIVFAMSSKRA 266
Cdd:TIGR00711 172 VAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEG---------PERGWFDSNEILILSITGLVAIIAFVVWELTD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  267 FSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFGAVK 346
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  347 PILIPLGIAILGPVLMLV-FSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAGTA 425
Cdd:TIGR00711 323 LVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402


                  ....*..
gi 494113220  426 LFSTILS 432
Cdd:TIGR00711 403 LITTILT 409
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 26-471 3.64e-34

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 131.91  E-value: 3.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  26 AFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAF 105
Cdd:cd17321    5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 106 PLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPlvliaa 185
Cdd:cd17321   85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP------ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 186 cigmkcieqktpteaayldpiqlgsivVALVGLVLALNQGGVAISAAVSGksatrsgiiaivsliaglallivfamsskr 265
Cdd:cd17321  159 ---------------------------IGLVALLLARTFSGAVLAAFLLG------------------------------ 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 266 afspllrlgilkdpavllhacaylllpLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFGAV 345
Cdd:cd17321  182 ---------------------------AALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 346 KPILIPLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAGTA 425
Cdd:cd17321  235 LVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVA 314

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 494113220 426 LFSTILSVAQAGAGEEGTAEFAHATAV-----GGTWTFATMTVICLIGWCC 471
Cdd:cd17321  315 LLGALLTAGLSANLGDSGVAALLSAAAaafaaGFHLAFLVAAALALLAALL 365
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-422 1.35e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.06  E-value: 1.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  10 KIPTRLIGAIVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAV 89
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  90 ILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLP 169
Cdd:COG2814   83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 170 WRAIFVIAIPLVLIAAcigmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsl 249
Cdd:COG2814  163 WRWVFLVNAVLALLAL---------------------------------------------------------------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 250 iAGLALLIVFAMSSKRAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGA 329
Cdd:COG2814  179 -LLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 330 VCAPLGGWFYDKFGAVKPILIPLGIAILGpvlMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGN 409
Cdd:COG2814  258 LGALLAGRLADRFGRRRLLLIGLLLLALG---LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334

                        410
                 ....*....|...
gi 494113220 410 AIFNTCLQFGGAA 422
Cdd:COG2814  335 GLYNSAFFLGGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 25-479 8.10e-24

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 102.66  E-value: 8.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  25 LAFIGILTETVMTVLFPAL---MREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd17504    1 LALAALAVMLVETMLSPALptiQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 102 AQAFPLLIVARIIQGIGSGVaTPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLV 181
Cdd:cd17504   81 APNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 182 LIAAcigmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsliaglallivfam 261
Cdd:cd17504  160 VLLA---------------------------------------------------------------------------- 163

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 262 sskrAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQL----SLGTTAFVAGSLVLPGALVGAVCAPLGGW 337
Cdd:cd17504  164 ----ALVPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGR 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 338 FYDKFGAVKPILIPLGIAILGPVLMLVFSmqLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQ 417
Cdd:cd17504  240 LIARVGPRRVLLIGLVISAVGLLLLALLH--SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRT 317

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494113220 418 FGGAAGTALFSTILSvaqagAGEEGTAEFAHATAVGGTWTFATMTVICLIGwccLATAFRIR 479
Cdd:cd17504  318 IGSAIGPAIAGAILT-----TYTVSITSGGVPTEGAYVLAFLIGAALALAA---LLLSLLIP 371
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 12-297 1.68e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 94.49  E-value: 1.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  12 PTRLIGAIVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVIL 91
Cdd:COG0477    9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  92 AIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWR 171
Cdd:COG0477   89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 172 AIFVIAIPLVLIAACIGMKCIEQKTPTEAAYLDPIQLGSIVVALVGLVLALNQGGVAISAAVSGKSATRSGIIAIVSLIA 251
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 494113220 252 GLALLIVFAMSSKRAFSPLLRLGILKDPAVLLHACAYLLLPLVAIG 297
Cdd:COG0477  249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_1 pfam07690
Major Facilitator Superfamily;
24-424 3.76e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.41  E-value: 3.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   24 SLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQ 103
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  104 AFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLI 183
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  184 AAcigmkcieqktpteaayldpiqlgsivvalVGLVLALNQGGVAISAAVSGKSATRSGIIAIVSLIAGLALLIVFAMSS 263
Cdd:pfam07690 164 AA------------------------------VLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  264 krafspllrlgilkdpavllhacaylllplVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFG 343
Cdd:pfam07690 214 ------------------------------FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  344 AVKPILIPLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAG 423
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343


                  .
gi 494113220  424 T 424
Cdd:pfam07690 344 P 344
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 27-185 9.06e-21

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 93.01  E-value: 9.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  27 FIGILTETVMTVLFPALMREFHvDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFP 106
Cdd:cd17502    6 FLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMT 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494113220 107 LLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAA 185
Cdd:cd17502   85 MLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLAL 163
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 26-423 1.15e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 87.63  E-value: 1.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  26 AFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAF 105
Cdd:cd17325    5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 106 PLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAA 185
Cdd:cd17325   85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLAL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 186 CIGMKCIEQKTPTEAAyldpiqlgsivvalvglvlalnqggvaiSAAVSGKSATRSGIIAIVSLIAGLALLIVFAMSSKR 265
Cdd:cd17325  165 VLALLLLPEPRPPPNK----------------------------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 266 AFSPLLRLgilkdpavllhacaylllplvaigygyvitnVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFGAV 345
Cdd:cd17325  217 ALEPFLPL-------------------------------YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK 265

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494113220 346 KPILIPLgiaILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAG 423
Cdd:cd17325  266 PLILIGL---LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-176 1.02e-16

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 81.47  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494113220  99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVI 176
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF 158
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-365 1.55e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 81.07  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   9 EKIPTRLIGAIVAVGSLA-FIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLA 87
Cdd:COG2271    1 ARAPSRYRWRILALLFLAyFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  88 AVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTV 167
Cdd:COG2271   81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 168 LPWRAIFVIAIPLVLIAACIGMkcieqktpteaayldpIQLGSIVVALVGLVLALNQGGVAISAAVSGKSATRSGIIAIV 247
Cdd:COG2271  161 FGWRAAFLILGLPGLLLALLRF----------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 248 SLIAGLALLIVFAMSSKRAFSPLLRLGILkdpAVLLHACAYLLLPLV----AIGYGYVITNVAQLSLGTTAFVAGSLVLP 323
Cdd:COG2271  225 PFLAGIVGSLLGGWLSDRLGRRRKLVLAI---GLLLAALALLLLALLpspaLAIALLFLAGFGLGGAFGLLWALAAELFP 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 494113220 324 --------------GALVGAVCAPLGGWFYDKFGAVKPILIPLGIAILGPVLMLVF 365
Cdd:COG2271  302 kkargtasglvntfGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 19-229 4.75e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 79.54  E-value: 4.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVlPWRAIFVIAI 178
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 494113220 179 PLVLIAAcIGMKCIEQKTPTEAAYLDPIQLGSIVVALVGLVLALNQGGVAI 229
Cdd:cd17474  160 ALIPVAF-LAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFL 209
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 19-432 2.88e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 77.20  E-value: 2.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAI 178
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 179 PLVLIAACIgmkcieqktpteaayldpiqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsLIAGLALLIV 258
Cdd:cd17324  161 VLALLAALL-------------------------------------------------------------LWRLLPSLPP 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 259 FAMSSKRAFSPLLRLgiLKDPAVLLHACAYLLLPLVAIG-YGYVITNVAQLSLGTTAFVAGSLVLPGaLVGAVCAPLGGW 337
Cdd:cd17324  180 KKPGSLGLLSSLLLL--LRNPRLRLAYLITFLLFGGFFAlYTYLAPFLTDVPGFSSSAIIGLLLLFG-VAGVVGSPLAGR 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 338 FYDKFGAVKPILIPLGIAILGPVLMLVFSmqlTPVLLAGFYFIFGLFYSIGNANVMTSgLSEVSPEFKPDGNAIFNTCLQ 417
Cdd:cd17324  257 LADRGGRRALLIALLLLAAALLLLTLLGP---SPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYN 332

                        410
                 ....*....|....*
gi 494113220 418 FGGAAGTALFSTILS 432
Cdd:cd17324  333 LGGALGAALGGLVLD 347
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
18-392 2.91e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 74.15  E-value: 2.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  18 AIVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSL 97
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  98 IMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIA 177
Cdd:COG2223   86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 178 IPLVLIAACIGMkcieqktpteaayldpiqlgsivvalvgLVLALNQGGVAISAAVSGKSAtrsgiiaivsliaglalli 257
Cdd:COG2223  166 GILLLVVAVLAW----------------------------LFLRDPPAGAAAAAKASLRDQ------------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 258 vfamsskrafspllrLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGW 337
Cdd:COG2223  199 ---------------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGW 263

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 494113220 338 FYDKFGAVKPILIPLGIAILGPVLMLVFSMQLTPVLLAGfyFIFGLFYSIGNANV 392
Cdd:COG2223  264 LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLF--LLLGLALGGGNGAV 316
PRK10504 PRK10504
putative transporter; Provisional
 19-185 8.14e-13

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 70.15  E-value: 8.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGslAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:PRK10504  14 IVAFG--FFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAI 178
Cdd:PRK10504  92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171


                 ....*..
gi 494113220 179 PLVLIAA 185
Cdd:PRK10504 172 PVGIIGA 178
PRK14995 PRK14995
SmvA family efflux MFS transporter;
34-343 1.61e-12

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 69.37  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  34 TVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARI 113
Cdd:PRK14995  23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 114 IQGIGSGVATPLMI----NIILEQSPRSKIgrlMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAACIGM 189
Cdd:PRK14995 103 LLAIGAAMIVPATLagirATFTEEKQRNMA---LGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 190 KCIeqktPTEAAYLD-PIQLGSIVVALVGLVLALnqggVAISAAVSGKSATrsgIIAIVSLIAGLALLIVFAMSSKRAFS 268
Cdd:PRK14995 180 RYV----PRQAGRRDqPLNLGHALMLIVAILLLV----YSAKTALKGFLSL---WVTSLTLLTGALLLGLFIRTQLAASR 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494113220 269 PLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFYDKFG 343
Cdd:PRK14995 249 PMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 19-187 1.73e-12

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 68.95  E-value: 1.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   19 IVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:TIGR00710   7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIF-VIA 177
Cdd:TIGR00710  87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFaFLS 166

                         170
                  ....*....|
gi 494113220  178 IPLVLIAACI 187
Cdd:TIGR00710 167 LAGILLSALI 176
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 20-432 6.35e-12

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 67.65  E-value: 6.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  20 VAVGSLAFIGILTETVMTVLFPALMREFHVDTATVqWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIM 99
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 100 IVAQAFPLLIVARIIQGIGSGVAtPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLP--WRAIFVIA 177
Cdd:cd06179   80 GTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 178 IPLVLIAACIGMKCIEQKTPT---------EAAYLDPIQLGSIVVALVGLVLALNQGGVAISAavsgKSATrsgiiAIVS 248
Cdd:cd06179  159 AIFNALALILLFFFYHPPPRPqlhgsstrqKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPW----SSAH-----VIAP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 249 LIAGLALLIVFAM-SSKRAFSPLLRLGILKDP-----AVLLHACAYLLLPLVAIGYGYVITnvaqLSLGTTAFVAGSLVL 322
Cdd:cd06179  230 LVIGGVLLIAFGLyEWKGTKDGLLPPRLLFRGrnfalILIVAFVEGMIFYSLNIFWPQQIS----LLFTTDPLKAGLYQL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 323 PGALVGAVCAPLGGWFYDKFGAVKPILIpLGIAILGPVLMLVFSMQLTPVLLA-GFYFIFGLFYSIGNANVMTSGLSEVS 401
Cdd:cd06179  306 PFGLGTLFGAILAGLLLTKIKHIKWQLV-AGFVLFTAFLALLALITPDNKALAiAFSVLAGIGIGGPLVLAIVIVQLSVP 384

                        410       420       430
                 ....*....|....*....|....*....|.
gi 494113220 402 PEFKPDGNAIFNTCLQFGGAAGTALFSTILS 432
Cdd:cd06179  385 PEDIGTASGLLGSARALGGAVGTAIFTSILS 415
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
15-187 8.70e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 66.82  E-value: 8.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  15 LIGAIVAVGSLAFIGIlteTVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIV 94
Cdd:COG2807   19 LLLAIVLVALNLRPAI---TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  95 GSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRsKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIF 174
Cdd:COG2807   96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174

                        170
                 ....*....|...
gi 494113220 175 VIAIPLVLIAACI 187
Cdd:COG2807  175 AVWALLALLALLL 187
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 57-427 4.14e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 64.54  E-value: 4.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  57 ITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPR 136
Cdd:cd17489   36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 137 SKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAiplvliaacigmkcieqktpteaayldpiqlgsIVVALV 216
Cdd:cd17489  116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA---------------------------------AVLALL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 217 GLVLALNQGGVAISAAVSGKSATRSgiiaivsliaglallivfamsskrafspllrLGILKDPAVLLHAcayLLLPLVAI 296
Cdd:cd17489  163 ALLLVFLVKDPPPVAAEEAEAGTRA-------------------------------FRRLVEKKVLPPA---LILFLASI 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 297 GYGYVITNVAqLSLGTTAFVAGSLVLPG-ALVGAVCAPLGGWFYDKFGAVKPILIPLGIAILGpvlMLVFSMQLTPVLLA 375
Cdd:cd17489  209 AYGAISTFLP-LYAAERGISNAGLFFTVyAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG---LLLLSFAGSPWMLL 284

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 494113220 376 GFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFGGAAGTALF 427
Cdd:cd17489  285 LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
2_A_01_02 TIGR00880
Multidrug resistance protein;
59-185 6.82e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 57.27  E-value: 6.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   59 TIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSK 138
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 494113220  139 IGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAA 185
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAF 131
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-432 7.42e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.52  E-value: 7.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  22 VGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 102 AQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTT--VLPWRAIFVIAIP 179
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 180 LVLIAACIGMKCIEQKTPTEAAYLDPIqlgsivvalvglvlalnqggvaisaavsgksatrsgiiaivsliaglallivf 259
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEA----------------------------------------------------- 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 260 amssKRAFSPLLRLGILKDPAVLLHACAYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVGAVCAPLGGWFY 339
Cdd:cd06174  188 ----SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLS 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 340 DKFGAVKPILipLGIAILGPVLMLVFSMQLTPVLLAGFYFIFGLFYSIGNANVMTSGLSEVSPEFKPDGNAIFNTCLQFG 419
Cdd:cd06174  264 DRLIGRKPLL--LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLG 341

                        410
                 ....*....|...
gi 494113220 420 GAAGTALFSTILS 432
Cdd:cd06174  342 GAIGPLLAGFLLA 354
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 25-365 4.44e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 57.97  E-value: 4.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  25 LAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQA 104
Cdd:cd17319   11 AYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 105 FPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVI-AIPLVLI 183
Cdd:cd17319   91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIeGLLGLLL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 184 AA------------CIGMKCIEQKTPTEAAYLDPI--QLGSIVVALVGLVLALNQGGVAISAAVSGKSATRSGIIA-IVS 248
Cdd:cd17319  171 AVlwwfylrqvwglALGYFGINYALYGLLTWLPTYlkQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGArRLV 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 249 LIAGLALLIVFAMSSKRAFSPLLRLGILkdpavllhacaYLLLPLVAIGYGYVITNVAQLSLGTTAFVAGSLVLPGALVG 328
Cdd:cd17319  251 IIIGLLLAAVGLLLAYLTTSPVVAVILL-----------SLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLG 319

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 494113220 329 AVCAPLG-GWFYDKFGAVKPILIPLGIAILGPVLMLVF 365
Cdd:cd17319  320 GFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
40-190 1.06e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 56.85  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  40 FPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIgS 119
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL-A 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494113220 120 GVATPLMINIILEQS-PRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIF-VIAIPLVLIAACIGMK 190
Cdd:PRK11102  93 AAAASVVINALMRDMfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFwVLALAAILAAALVFFF 165
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 14-187 1.11e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.82  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  14 RLIGAIVAVGSLAFIGILTETVMTVLfpaLMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAI 93
Cdd:cd17325  200 RLLALFLAIFVLAFAFGALEPFLPLY---AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  94 VGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAI 173
Cdd:cd17325  277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356

                        170
                 ....*....|....
gi 494113220 174 FVIAIPLVLIAACI 187
Cdd:cd17325  357 FLAAAALLLLAAVL 370
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 25-406 2.07e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 56.21  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   25 LAFIGILTE----TVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMI 100
Cdd:TIGR00895  21 LSFLIMLMDgydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  101 VAQAFPLLIVARIIQGIGSGVATPLMINIILEQSP---RSKIGRLMGVGslvITVAPAIGPTVGGAVTTVLPWRAIFVIA 177
Cdd:TIGR00895 101 LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPkrfRGTAVGLMFCG---YPIGAAVGGFLAGWLIPVFGWRSLFYVG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  178 IPLVLIAACIGMK--------CIEQKTPTEAAYLDPIQLGSIVVALVGLVLALNQGGVAISAAVSGKSATRSGIIAIVSL 249
Cdd:TIGR00895 178 GIAPLLLLLLLMRflpesidfLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWL 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  250 IAGLALLIVFAMSSkrafspllrlgilkdpavllhacaylLLPLVAIGYGYvitnvaQLSLGTTAfvaGSLVLPGALVGA 329
Cdd:TIGR00895 258 LYFMLLVGVYFLTN--------------------------WLPKLMVELGF------SLSLAATG---GALFNFGGVIGS 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494113220  330 VcapLGGWFYDKFGAVKPILIPLGIAILgpvLMLVFSMQLTPVLLAGFYFIFGLFYsignaNVMTSGLSEVSPEFKP 406
Cdd:TIGR00895 303 I---IFGWLADRLGPRVTALLLLLGAVF---AVLVGSTLFSPTLLLLLGAIAGFFV-----NGGQSGLYALMALFYP 368
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 12-190 2.85e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 55.66  E-value: 2.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  12 PTRLIGAIVAVGSLAFIGIltetvMTVLFPALMREFHVDTATVQWITTIY-LLAVAATMPISSFLKRRFALKTIFLAAVI 90
Cdd:cd17330  175 PLRRLLLVYFLIALAFAGL-----ESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLL 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  91 LAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPW 170
Cdd:cd17330  250 LAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329

                        170       180
                 ....*....|....*....|
gi 494113220 171 RAIFVIAIPLVLIAACIGMK 190
Cdd:cd17330  330 GVPFLLAAGLLLIALFLLSL 349
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 24-263 4.47e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.89  E-value: 4.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  24 SLAFIGILTETVMTVLFPALMREFH-VDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVA 102
Cdd:cd17473    6 LASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 103 QAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTvLPWRAIF---VIAIP 179
Cdd:cd17473   86 DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFlvyLLALP 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 180 -LVLIAACIGMKCIEQKTPTEAA--------------------------YLDPIQLGSIVV-------ALVGLVLALNQG 225
Cdd:cd17473  165 vLILVLLFLPEPARKSKSAASPGaataaalpwkrvlpiyflaflamllfYVIPIQLPFLLQergggsaALIGLALAIASL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 494113220 226 GVAISAAVSGKSA---TRSGIIAIVSLIAGLALLIVFAMSS 263
Cdd:cd17473  245 AGAIGALLFGRLKrrlGKRRLLAIGFALMALGFLLLALASG 285
emrD PRK11652
multidrug transporter EmrD;
15-175 4.51e-08

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 54.91  E-value: 4.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  15 LIGAIVAVGSLAfigiltETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIV 94
Cdd:PRK11652  12 MLVLLVAVGQMA------QTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFIL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  95 GSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIF 174
Cdd:PRK11652  86 GTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACY 165


                 .
gi 494113220 175 V 175
Cdd:PRK11652 166 L 166
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 34-188 5.72e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 54.51  E-value: 5.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  34 TVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARI 113
Cdd:cd17365   16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494113220 114 IQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVI-AIPLVLIAACIG 188
Cdd:cd17365   96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLgGVPPLILLPLLR 171
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 26-255 5.98e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 54.49  E-value: 5.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  26 AFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAF 105
Cdd:cd17477    5 VALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 106 PLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWR-----AIFVIAIPL 180
Cdd:cd17477   85 WVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPfliaaVLLLLALVP 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494113220 181 VLIAACIGMKCIEQKTPTEAAYLDPIQLGSIVVALVGLVLALNQGGVAISAAVSGKSATRSGIIAIVSLIAGLAL 255
Cdd:cd17477  165 LLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLL 239
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 22-174 9.55e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 54.12  E-value: 9.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  22 VGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd17323    4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494113220 102 AQAFPLLIVARIIQGIGSgvATPLMIN--IILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIF 174
Cdd:cd17323   84 APNIAMLIILRFLQGFFG--SSPLAIGagTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-201 6.91e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 6.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  12 PTRLIGAIVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVIL 91
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  92 AIVGSLIMIVAQAFPLLIVARIIQGIGSG---VATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVL 168
Cdd:COG0738   83 MALGLLLFALAPSYPLLLLALFLLGLGLGlldVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 494113220 169 PWRAIFVIAIPLVLIAACIGMKCIEQKTPTEAA 201
Cdd:COG0738  163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEE 195
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 62-213 8.96e-07

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 50.81  E-value: 8.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  62 LLAVAATMPISSFLKRRfalKTIFLAAVILaIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGR 141
Cdd:cd17362   53 LLGSLVAGALIDRLGRR---KELILAALLY-LVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGL 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494113220 142 LMGVGSLVITVAPAIGPTVGGA-VTTVLPWRAIFVIAIPLVLIAAcIGMKCIEQKTPTEAAYLDPIQLGSIVV 213
Cdd:cd17362  129 LVSLKELFIVLGILLGYVSGYAfADVVGGWRYMYGLAAPPALLLG-IGMWFLPPSPRWQGNYRKPLIIGLGLV 200
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
19-164 1.11e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494113220  99 MIVAQA--FPLLIVARIIQGIGSGVATPLMINIILE-------QSPRSKIGRLMGVGSLVITVAPAIGPTVGGAV 164
Cdd:COG2211  311 LFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 35-384 4.02e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 48.71  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  35 VMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARII 114
Cdd:cd17478   14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 115 QGIGSGVATPLMINIILEQSPRSKiGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLvliaacigmkcieq 194
Cdd:cd17478   94 AGIGSAAFHPEGARLASQAAGGRR-GLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIP-------------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 195 ktpteaayldpiqlGSIVVALVGLVLALNQGGVAISAAVSGKSATRSGIIAIVSLIAGLALLIVFAMSSKRAFSPLLrlg 274
Cdd:cd17478  159 --------------GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFY--- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 275 ilkdpavllhacaylllpLVAIGYGYVITNVAQlslgtTAFvagslvlpgALVGAVCAPLGGWFYDKFGAvKPILIplgI 354
Cdd:cd17478  222 ------------------LVQRGYSLVFAGLLL-----SLF---------LFAGAIGTLIGGPLSDRFGR-RRVII---A 265

                        330       340       350
                 ....*....|....*....|....*....|
gi 494113220 355 AILGPVLMLVFSMQLTPVLLAGFYFIFGLF 384
Cdd:cd17478  266 SLLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 19-183 4.45e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 49.11  E-value: 4.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  19 IVAVGSLAFIGIL--TETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGS 96
Cdd:cd17358    6 VANLGSFSFGIAVgwSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  97 LIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLmgvgSLVITVAPAIGPTVGGAVTTVLPWR--AIF 174
Cdd:cd17358   86 LLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL----GSLNQLLVNIGILLGYVLGSFLPWRtlALI 161


                 ....*....
gi 494113220 175 VIAIPLVLI 183
Cdd:cd17358  162 GAIPPVVFL 170
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 53-187 4.83e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.80  E-value: 4.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  53 TVQW--ITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFP---LLIVARIIQGIGSGVATPLMI 127
Cdd:cd17357   48 DLLWslIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIACGLSTGFVP 127

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494113220 128 NIILEQSP---RSKIGRLMGVG-SLVITVAPAIG-PTVGGAVTTvlpWRAIFVIAIPLVLIAACI 187
Cdd:cd17357  128 MYLQEISPselRGALGSLTQIGvTLGILLGQVFGlPSVLGTETL---WPYLLFFPGIPALLQLAA 189
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 46-185 6.01e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 48.34  E-value: 6.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  46 EFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPL 125
Cdd:cd17315   28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494113220 126 MINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLP--WRAIFVIAIPLVLIAA 185
Cdd:cd17315  108 VPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQL 169
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 31-176 7.37e-06

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 48.17  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  31 LTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIV 110
Cdd:PRK10091  17 MAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAI 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494113220 111 ARIIQGIGSGvATPLMINIILEQ-SPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVI 176
Cdd:PRK10091  97 GRLVSGFPHG-AFFGVGAIVLSKiIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLL 162
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
207-467 8.46e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.97  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 207 QLGSIVVALVGLVLALNQGGvaisaavsGKSATRSGIIAIVSLIAGLALLIVFAMSSKRAFSPLLRLG-------ILKDP 279
Cdd:COG2211  157 GLGGLLASVLPPPLVAAFGG--------DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSlkeslkaLLKNR 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 280 AVLLHACAYLL----LPLVAIGYGYVITNVAQLSLGTTAFVAGSlvlpGALVGAVCAPLGGWFYDKFGAVKPILIPLGIA 355
Cdd:COG2211  229 PFLLLLLAYLLfflaLALVAALLLYYFKYVLGLSAALVGLLLAL----YFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 356 ILGPVLMLVFSMQlTPVLLAGFYFIFGLFYSIGNAnVMTSGLSEVSPEFKPDGN--------AIFNTCLQFGGAAGTALF 427
Cdd:COG2211  305 ALGLLLLFFLGPG-NLWLLLVLAALAGIGLGAILV-LPWAMLADVVDYDEWKTGrrreglyfGIFTFAIKLGQALAGALA 382

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 494113220 428 STILSVAQAGAGEEGTAEFAHATAVGGTWTFATMTVICLI 467
Cdd:COG2211  383 GLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAAL 422
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 34-186 9.38e-06

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 9.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  34 TVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMiVAQAFPLLIVARI 113
Cdd:cd17339   16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLR-SLGGIALLFLGTA 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494113220 114 IQGIGSGVATPLMINIILEQSPRsKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLP--WR-AIFVIAIPLVLIAAC 186
Cdd:cd17339   95 LAGAGIAVGNVLLPSLIKRDFPR-RVGLMTGLYTTSMNLGAALASGLSVPLAQALGggWRgALAIWALPALLALLI 169
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 25-188 9.75e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.57  E-value: 9.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  25 LAFIGILTETVMTVLFPALMREFHVDTAT---VQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:cd17330    4 VVFLDALGFGIVFPVLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 102 AQAFPLLIVARIIQGIGSGvATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLV 181
Cdd:cd17330   84 SRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162


                 ....*..
gi 494113220 182 LIAACIG 188
Cdd:cd17330  163 LLNLVLV 169
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 25-190 1.34e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.22  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  25 LAFIGILTETVMTVLFPALMRE-FHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQ 103
Cdd:cd06173  216 ALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 104 AFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLI 183
Cdd:cd06173  296 SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLL 375


                 ....*..
gi 494113220 184 AACIGMK 190
Cdd:cd06173  376 AALLLLL 382
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 58-261 1.71e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 47.35  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   58 TTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVA--TPLMINIILeqSP 135
Cdd:pfam06609  84 STLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAgaSPLFIGELM--SN 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  136 RSKIGRLMGVGSLVITVAPAiGPTVGGAVTTVLPWRAIFVIAIPLVLIAACI--------------GMKCIEQKtptEAA 201
Cdd:pfam06609 162 KTKFLGLLIVSAPTIAMNGA-GPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLiiiwyhppsfaqlhGKKARKRD---ELA 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  202 YLDPIQLGSIVVALVGLVLALNQGGVAISAAVSGKsatrsgIIAIVSliAGLALLIVFAM 261
Cdd:pfam06609 238 KLDWIGIFLVIAGTSLFLLGVSWGGKPNNPWNSAK------IIGLIS--SGAGSLVIFAL 289
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 34-176 2.56e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.39  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  34 TVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI--MIVAQAFPLLIVA 111
Cdd:cd17380   16 VNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILS 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494113220 112 RIIQGIGSGVATPLMINIILEQSPRSKIGRLMGvgslVITVAPAIGPTVGGAVTTVLP----WRAIFVI 176
Cdd:cd17380   96 RILLGLGEGVHFPSMTSLFSRWVPVSERSRAVS----IVTAGSYLGTLLGGLIGPLLLeyygWPSVFYF 160
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 22-187 3.01e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 46.07  E-value: 3.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  22 VGSLAFIGILT---ETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLI 98
Cdd:cd17328    1 VAVLFLINLLNymdRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  99 MIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTT-VLPWRAIFVIA 177
Cdd:cd17328   81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVT 160

                        170
                 ....*....|
gi 494113220 178 IPLVLIAACI 187
Cdd:cd17328  161 GVLGVLLAIL 170
Sugar_tr pfam00083
Sugar (and other) transporter;
56-152 3.30e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.11  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   56 WITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVA---QAFPLLIVARIIQGIGSGVATPLMINIILE 132
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISE 129

                          90       100
                  ....*....|....*....|
gi 494113220  133 QSPRSKIGRLMGVGSLVITV 152
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITF 149
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 57-186 6.96e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 44.95  E-value: 6.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  57 ITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPR 136
Cdd:cd17360   40 IVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPP 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 494113220 137 SKIGRLMGVGSLVITVAPAIGPTVGGAVTTV-LPWRAIF-VIAIPLVLIAAC 186
Cdd:cd17360  120 RIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLgLAAVPAVLQFIG 171
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 35-187 1.16e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 44.48  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  35 VMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARII 114
Cdd:cd17359   19 VINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARII 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 115 QGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVIT--------VAPAIGPTVGGAVTTVLPWRAIFVI-AIPLVLIAA 185
Cdd:cd17359   99 GGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVfgqllayiVNYLIANAGGADWLGAEGWRWMLGLeAIPAILFLL 178


                 ..
gi 494113220 186 CI 187
Cdd:cd17359  179 GM 180
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 71-192 1.32e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 44.16  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  71 ISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQ-AFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLV 149
Cdd:cd17356   64 ISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIgKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLA 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 494113220 150 ITVAPAIGPTVGGAVTTVLPwRAIFVIAIPLVLIAA---CIGMKCI 192
Cdd:cd17356  144 ITIGILVAYCINYGTHKLDG-SAQWRIPLGLQIVWGlllLIGMFFL 188
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
59-175 1.58e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 43.86  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  59 TIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSG---VATPLMINIILEQSP 135
Cdd:PRK10473  45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGccyVVAFAILRDTLDDRR 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 494113220 136 RSKIGRLMgvgSLVITVAPAIGPTVGGAVTTVLPWRAIFV 175
Cdd:PRK10473 125 RAKVLSLL---NGITCIIPVLAPVLGHLIMLKFPWQSLFY 161
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 41-183 1.84e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.80  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  41 PALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSG 120
Cdd:PRK11551  39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494113220 121 VATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVI--AIPLVLI 183
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVggVGPLLLV 183
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 15-102 2.42e-04

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 43.58  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   15 LIGAIVAVG-SLAFigiltETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAI 93
Cdd:TIGR00892  21 LGATFVSIGfSYAF-----PKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLAS 95


                  ....*....
gi 494113220   94 VGsliMIVA 102
Cdd:TIGR00892  96 LG---MILA 101
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
43-186 3.31e-04

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 42.89  E-value: 3.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  43 LMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVA 122
Cdd:PRK15403  42 VVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFI 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494113220 123 TPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAAC 186
Cdd:PRK15403 122 ATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFV 185
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 34-185 3.97e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  34 TVMTVLFPALMREFHVDTATVQ--WITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVA 111
Cdd:cd17316   16 FLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494113220 112 RIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLP----WRAIFVIAIPLVLIAA 185
Cdd:cd17316   96 RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLAL 173
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
41-184 4.52e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 42.62  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  41 PALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSG 120
Cdd:PRK15402  37 LAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494113220 121 VATPL---MINIILEQSPRSKIGRLMGVGSLVitvAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIA 184
Cdd:PRK15402 117 FIGAVgyaAIQESFEEADAIKITALMANVALL---APLLGPLVGAALIHVLPWRGMFVLFAALAALS 180
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 63-195 6.34e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.87  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  63 LAVAATMPISSFLKRRFALKTIFLAAVI-LAIVGSLIMIVAQAFPLLIVaRIIQGIGSGVATPLMInIILEQSPRSKIGR 141
Cdd:cd17391   47 LVSAIFSPIWGRLADRYGRKPMLLRASLgMAIVIGLMAFVTNVWQLLIL-RLLQGVFSGYVPNATA-LIASQTPKEKSGW 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 494113220 142 LMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAACIGMKCIEQK 195
Cdd:cd17391  125 ALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKED 178
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-189 8.01e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 8.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  15 LIGAIVAVGSLAFIGILTetvmtvLFPALMREFHVDTATVqwITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIV 94
Cdd:cd17489  198 PPALILFLASIAYGAIST------FLPLYAAERGISNAGL--FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  95 GSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIF 174
Cdd:cd17489  270 GLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF 349

                        170
                 ....*....|....*
gi 494113220 175 VIAIPLVLIAACIGM 189
Cdd:cd17489  350 LLAAVVVLLALVLYI 364
SpoIIE COG5817
Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell ...
 61-292 8.37e-04

Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444519 [Multi-domain]  Cd Length: 803  Bit Score: 42.18  E-value: 8.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  61 YLLAVAATMPISSFLKRRFALKTI---FLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINII--LEQSP 135
Cdd:COG5817   99 YLAALLLFLLLSKFLKRKKKKKILvlpLLVFLSVLVVGLVYLAFGGGSPYDLLMALFEAILAFVLTYIFLQALplLTEKR 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 136 RSKIGRLMGVGSLVITVApaigptvgGAVTTVLPWRaIFVIAIPLVLIAACIGMkcieqktpteAAYLDPIQLGSIVVAL 215
Cdd:COG5817  179 KRKSLTNEEIICLLILLA--------SVLTGLGGLT-IGGLSLKNILSRLLVLL----------AAYIGGAGLGAAVGVV 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 216 VGLVLALNQGGVAISAAVSGKSATRSG-------IIAIVSLIAGLALLIVFAMSSKRAFSPLLRLGIlkdpAVLLhacaY 288
Cdd:COG5817  240 IGLILSLSNGSSPYMIGLYAFAGLLAGlfrefgkLGVALGFLLGNLLLTLYVSGSGELLLSLYEIAI----ASLL----F 311


                 ....
gi 494113220 289 LLLP 292
Cdd:COG5817  312 LLLP 315
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 64-164 8.98e-04

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 41.47  E-value: 8.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  64 AVAATMPISSFLKRRFALKTIFLAAVILAIvGSLIMIVAQaFPLLIVARIIQGIGsgvATPLM---INIILEQSPRSKIG 140
Cdd:cd17403   52 SVLLLLFVSYFGGRGHKPRWLGIGAFIMGI-GSLVFALPH-FTVFILAQLLHGAG---ATPLYtlgVTYLDENVSTKMSP 126

                         90       100
                 ....*....|....*....|....
gi 494113220 141 RLMGVGSLVITVAPAIGPTVGGAV 164
Cdd:cd17403  127 LYIGIFYAMAILGPAIGYVLGGFL 150
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-201 9.26e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.40  E-value: 9.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  13 TRLIGAIVAVGSLAFIGILTetvmtVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILA 92
Cdd:COG2223  207 FWLLSLLYFGTFGSFIGFSS-----WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  93 IVGSLIMIVAQA-FPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVL-PW 170
Cdd:COG2223  282 ALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSY 361

                        170       180       190
                 ....*....|....*....|....*....|.
gi 494113220 171 RAIFVIAIPLVLIAACIGMKCIEQKTPTEAA 201
Cdd:COG2223  362 TAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 36-118 1.10e-03

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 41.25  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  36 MTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAivgSLIMIVA----QAFPLLIVA 111
Cdd:cd17430   22 VSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLA---SLGMILAsfctSIIQLYLTA 98


                 ....*..
gi 494113220 112 RIIQGIG 118
Cdd:cd17430   99 GVITGLG 105
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 59-185 1.20e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  59 TIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSK 138
Cdd:cd17370  241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL 320

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 494113220 139 IGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAA 185
Cdd:cd17370  321 RGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 82-186 1.32e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.10  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  82 KTIFLAAVILAIVGSLIMIVAQAFPLLIVaRIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVG 161
Cdd:cd17391  271 RILLGALLASALLYIPQAFVQTPWQLGIL-RFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349

                         90       100
                 ....*....|....*....|....*
gi 494113220 162 GAVTTVLPWRAIFVIAIPLVLIAAC 186
Cdd:cd17391  350 SAIAAHFGYRAVFVVTALLVLLNAI 374
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 55-186 1.42e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 41.17  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   55 QWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMI---VAQAFPLLIVARIIQGIGSGVATPLMINIIL 131
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGlaaFALSVEMLIVGRVLLGIGVGIASALVPMYLS 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 494113220  132 EQSPRSKIGRLMGVGSLVIT----VAPAIGPTVGGAVTTVLpWRAIFVIAIPLVLIAAC 186
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITfgilVAYGFGSGKVSLNNTLG-WRIPLGLQLIPAGLLFL 211
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 84-189 1.45e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.67  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  84 IFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGA 163
Cdd:cd17390  242 LLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGL 321

                         90       100
                 ....*....|....*....|....*.
gi 494113220 164 VTTVLPWRAIFVIAipLVLIAACIGM 189
Cdd:cd17390  322 LQEFSVSGPGLLGA--VLALAAILLM 345
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 74-185 1.95e-03

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 40.55  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  74 FLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVA 153
Cdd:cd17435   58 VLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIG 137

                         90       100       110
                 ....*....|....*....|....*....|...
gi 494113220 154 PAIGPTVGGAVTTVLP-WRAIFVIAIPLVLIAA 185
Cdd:cd17435  138 ILLAYISNYAFANVSNgWKYMFGLVIPLAALQA 170
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 39-166 2.15e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 40.37  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  39 LFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFA-LKTIFLAAVILAIVGSLIMI----VAQAFPLLIVARI 113
Cdd:cd17322  308 LYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVGMGLLIryrgGSGSHGGIIGALI 387

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 494113220 114 IQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTT 166
Cdd:cd17322  388 LIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWT 440
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 25-164 2.23e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 40.37  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220   25 LAFIGILTETVMTVLFPAL---MREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIV 101
Cdd:pfam13347 229 LLASFLLAALAMGVLNGLLlyyFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALL 308

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494113220  102 AQA--FPLLIVARIIQGIGSGVATPLMINIILE-------QSPRSKIGRLMGVGSLVITVAPAIGPTVGGAV 164
Cdd:pfam13347 309 LGPnnTLLFLVLYIIIGFGYGSSFFLPWSMLADvvdygelRTGKRREGTFFAMWSFISKLATGVGLGVSGLL 380
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 78-184 2.79e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.89  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  78 RFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIG--SGVATPLMINIILEQsprsKIGRLMGVGSLVITVAPA 155
Cdd:cd17472   58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGaiSSVVMALLADLTREE----NRTKAMALIGASIGIAFA 133

                         90       100
                 ....*....|....*....|....*....
gi 494113220 156 IGPTVGGAVTTVLPWRAIFVIAIPLVLIA 184
Cdd:cd17472  134 ISMVLGPLLAAHLGVSGLFLITAILSLVS 162
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-166 3.02e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  21 AVGSLAFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIM- 99
Cdd:cd17321  173 AVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLa 252

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494113220 100 --IVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTT 166
Cdd:cd17321  253 llGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 54-187 3.31e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 39.49  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  54 VQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQGIGSGVATPLMINIILEQ 133
Cdd:cd17317   27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 494113220 134 SPrskiGRLMGVGSLVITVAPAIGPTVGGAVTTVLP-WRAI-FVIAIPLVLIAACI 187
Cdd:cd17317  107 VG----PKYRSFVGILFGLFWALGYMLLALLAYLIRdWRWLqLAISLPGLLFLLLL 158
PRK03545 PRK03545
putative arabinose transporter; Provisional
 26-113 4.31e-03

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 39.49  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  26 AFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAF 105
Cdd:PRK03545  18 AFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNF 97


                 ....*...
gi 494113220 106 PLLIVARI 113
Cdd:PRK03545  98 TVLLISRI 105
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 29-185 4.46e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  29 GILTETVMTvLFPALMREFHVDTATVQWITTIYLL-AVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPL 107
Cdd:cd17490  208 MITFSTTFG-FTPLIAKQLGASSFQLGLLSIIYLLpNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494113220 108 LIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFVIAIPLVLIAA 185
Cdd:cd17490  287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAA 364
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 36-197 4.70e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 39.17  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  36 MTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGSLIMIVAQAFPLLIVARIIQ 115
Cdd:cd17476   17 VIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQ 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220 116 GIGSGVATP---LMINIILEQSPRSKIgrlmgVGSLVITVAP---AIGPTVGGAVTTVLPWRAIFVIaipLVLIAACIGM 189
Cdd:cd17476   97 GLGPAFLLPnamALLGRTYPPGPRKNI-----VFSLFGATAPlgfALGGVFGGLFAQLAWWPWIFWF---LAILAAIVAV 168


                 ....*...
gi 494113220 190 KCIEQKTP 197
Cdd:cd17476  169 AAIFWTSP 176
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 18-176 5.93e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 5.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  18 AIVAVGSL-AFIGILTETVMTVLFPALMREFHVDTATVQWITTIYLLAVAATMPISSFLKRRFALKTIFLAAVILAIVGS 96
Cdd:cd17355    3 VVLAVTFLiLILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  97 LIMIVAQAFPLLIVAR-IIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGSLVITVAPAIGPTVGGAVTTVLPWRAIFV 175
Cdd:cd17355   83 VLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162


                 .
gi 494113220 176 I 176
Cdd:cd17355  163 V 163
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 71-161 9.57e-03

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 38.37  E-value: 9.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494113220  71 ISSFLKRRFALKTIFLAAVILAIVGSLIM---IVAQAFPLLIVARIIQGIGSGVATPLMINIILEQSPRSKIGRLMGVGS 147
Cdd:cd17432   69 LVGPLVIRLGRKGTLLLNNIFAIVAAILMglsKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPA 148

                         90
                 ....*....|....
gi 494113220 148 LVITVAPAIGPTVG 161
Cdd:cd17432  149 IFITLGILLGQVLG 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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