class III extradiol ring-cleavage dioxygenase [Hoeflea phototrophica]
Protein Classification
DODA-type extradiol aromatic ring-opening family dioxygenase( domain architecture ID 10164192)
DODA-type extradiol aromatic ring-opening family dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into substrates resulting in the cleavage of aromatic rings, similar to 4,5-DOPA extradiol dioxygenase, which opens the cyclic ring of 4,5-dihydroxy-phenylalanine (DOPA) to form betalamic acid
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| 45_DOPA_Dioxygenase | cd07363 | The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both ... |
8-267 | 3.72e-109 | |||||
The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. : Pssm-ID: 153375 Cd Length: 253 Bit Score: 316.01 E-value: 3.72e-109
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| Name | Accession | Description | Interval | E-value | |||||
| 45_DOPA_Dioxygenase | cd07363 | The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both ... |
8-267 | 3.72e-109 | |||||
The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Pssm-ID: 153375 Cd Length: 253 Bit Score: 316.01 E-value: 3.72e-109
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| LigB | COG3384 | Aromatic ring-opening dioxygenase, catalytic subunit, LigB family [Secondary metabolites ... |
7-269 | 4.71e-107 | |||||
Aromatic ring-opening dioxygenase, catalytic subunit, LigB family [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 442611 Cd Length: 260 Bit Score: 310.95 E-value: 4.71e-107
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| PRK10628 | PRK10628 | LigB family dioxygenase; Provisional |
31-237 | 2.86e-50 | |||||
LigB family dioxygenase; Provisional Pssm-ID: 182598 Cd Length: 246 Bit Score: 165.66 E-value: 2.86e-50
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| LigB | pfam02900 | Catalytic LigB subunit of aromatic ring-opening dioxygenase; |
9-237 | 6.42e-35 | |||||
Catalytic LigB subunit of aromatic ring-opening dioxygenase; Pssm-ID: 397167 [Multi-domain] Cd Length: 260 Bit Score: 126.31 E-value: 6.42e-35
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| Name | Accession | Description | Interval | E-value | |||||
| 45_DOPA_Dioxygenase | cd07363 | The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both ... |
8-267 | 3.72e-109 | |||||
The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Pssm-ID: 153375 Cd Length: 253 Bit Score: 316.01 E-value: 3.72e-109
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| LigB | COG3384 | Aromatic ring-opening dioxygenase, catalytic subunit, LigB family [Secondary metabolites ... |
7-269 | 4.71e-107 | |||||
Aromatic ring-opening dioxygenase, catalytic subunit, LigB family [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 442611 Cd Length: 260 Bit Score: 310.95 E-value: 4.71e-107
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| PRK10628 | PRK10628 | LigB family dioxygenase; Provisional |
31-237 | 2.86e-50 | |||||
LigB family dioxygenase; Provisional Pssm-ID: 182598 Cd Length: 246 Bit Score: 165.66 E-value: 2.86e-50
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| LigB | pfam02900 | Catalytic LigB subunit of aromatic ring-opening dioxygenase; |
9-237 | 6.42e-35 | |||||
Catalytic LigB subunit of aromatic ring-opening dioxygenase; Pssm-ID: 397167 [Multi-domain] Cd Length: 260 Bit Score: 126.31 E-value: 6.42e-35
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| Extradiol_Dioxygenase_3B_like | cd07320 | Subunit B of Class III Extradiol ring-cleavage dioxygenases; Dioxygenases catalyze the ... |
8-173 | 6.15e-25 | |||||
Subunit B of Class III Extradiol ring-cleavage dioxygenases; Dioxygenases catalyze the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms, resulting in the cleavage of aromatic rings. Two major groups of dioxygenases have been identified according to the cleavage site of the aromatic ring. Intradiol enzymes cleave the aromatic ring between two hydroxyl groups, whereas extradiol enzymes cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Extradiol dioxygenases can be further divided into three classes. Class I and II enzymes are evolutionary related and show sequence similarity, with the two-domain class II enzymes evolving from the class I enzyme through gene duplication. Class III enzymes are different in sequence and structure and usually have two subunits, designated A and B. This model represents the catalytic subunit B of extradiol dioxygenase class III enzymes. Enzymes belonging to this family include Protocatechuate 4,5-dioxygenase (LigAB), 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase (CarB), 4,5-DOPA Dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase, and 3,4-dihydroxyphenylacetate (homoprotocatechuate) 2,3-dioxygenase (HPCD). There are also some family members that do not show the typical dioxygenase activity. Pssm-ID: 153371 [Multi-domain] Cd Length: 260 Bit Score: 99.87 E-value: 6.15e-25
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| PCA_45_Doxase_B_like | cd07359 | Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar ... |
82-216 | 5.52e-13 | |||||
Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; This subfamily of class III extradiol dioxygenases consists of a number of proteins with known enzymatic activities: Protocatechuate (PCA) 4,5-dioxygenase (LigAB), 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), 3-O-Methylgallate Dioxygenase, 2-aminophenol 1,6-dioxygenase, as well as proteins without any known enzymatic activity. These proteins play essential roles in the degradation of aromatic compounds by catalyzing the incorporation of both atoms of molecular oxygen into their preferred substrates. As members of the Class III extradiol dioxygenase family, the enzymes use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. LigAB-like class III enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents the catalytic subunit, B. Pssm-ID: 153372 [Multi-domain] Cd Length: 271 Bit Score: 67.30 E-value: 5.52e-13
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| CarBb | cd07367 | CarBb is the B subunit of the Class III Extradiol ring-cleavage dioxygenase, 2-aminophenol 1, ... |
83-175 | 1.73e-11 | |||||
CarBb is the B subunit of the Class III Extradiol ring-cleavage dioxygenase, 2-aminophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-aminophenyl-2,3-diol; CarBb is the B subunit of 2-aminophenol 1,6-dioxygenase (CarB), which catalyzes the oxidization and subsequent ring-opening of 2-aminophenyl-2,3-diol. It is a key enzyme in the carbazole degradation pathway isolated from bacterial strains with carbazole degradation ability. The enzyme is a heterotetramer composed of two A and two B subunits. CarB belongs to the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Although the enzyme was originally isolated as a meta-cleavage enzyme for 2'-aminobiphenyl-2,3-diol involved in carbazole degradation, it has also shown high specificity for 2,3-dihydroxybiphenyl. Pssm-ID: 153379 [Multi-domain] Cd Length: 268 Bit Score: 62.84 E-value: 1.73e-11
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| HPCD_like | cd07362 | Class III extradiol dioxygenases with similarity to homoprotocatechuate 2,3-dioxygenase, which ... |
26-174 | 3.23e-11 | |||||
Class III extradiol dioxygenases with similarity to homoprotocatechuate 2,3-dioxygenase, which catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; This subfamily of class III extradiol dioxygenases consists of two types of proteins with known enzymatic activities; 3,4-dihydroxyphenylacetate (homoprotocatechuate) 2,3-dioxygenase (HPCD) and 2-amino-5-chlorophenol 1,6-dioxygenase. HPCD catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate (hpca), a central intermediate in the bacterial degradation of aromatic compounds. The enzyme incorporates both atoms of molecular oxygen into hpca, resulting in aromatic ring-opening to yield the product alpha-hydroxy-delta-carboxymethyl cis-muconic semialdehyde. 2-amino-5-chlorophenol 1,6-dioxygenase catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol, which is an intermediate during p-chloronitrobenzene degradation. The enzyme is probably a heterotetramer composed of two alpha and two beta subunits. Alpha and beta subunits share significant sequence similarity and both belong to this family. Like all Class III extradiol dioxygenases, these enzymes use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Pssm-ID: 153374 Cd Length: 272 Bit Score: 62.15 E-value: 3.23e-11
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| PRK13364 | PRK13364 | protocatechuate 4,5-dioxygenase subunit beta; Provisional |
83-197 | 3.21e-08 | |||||
protocatechuate 4,5-dioxygenase subunit beta; Provisional Pssm-ID: 184003 [Multi-domain] Cd Length: 278 Bit Score: 53.56 E-value: 3.21e-08
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| PRK13358 | PRK13358 | protocatechuate 4,5-dioxygenase subunit beta; Provisional |
83-176 | 3.57e-08 | |||||
protocatechuate 4,5-dioxygenase subunit beta; Provisional Pssm-ID: 183997 [Multi-domain] Cd Length: 269 Bit Score: 53.19 E-value: 3.57e-08
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| COG3885 | COG3885 | Aromatic ring-opening dioxygenase, LigB subunit [Secondary metabolites biosynthesis, transport ... |
18-173 | 4.62e-07 | |||||
Aromatic ring-opening dioxygenase, LigB subunit [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 443093 [Multi-domain] Cd Length: 273 Bit Score: 49.82 E-value: 4.62e-07
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| PRK13365 | PRK13365 | protocatechuate 4,5-dioxygenase subunit beta; Provisional |
83-173 | 1.29e-06 | |||||
protocatechuate 4,5-dioxygenase subunit beta; Provisional Pssm-ID: 184004 [Multi-domain] Cd Length: 279 Bit Score: 48.73 E-value: 1.29e-06
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| PCA_45_Doxase_B_like_1 | cd07949 | The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4, ... |
72-173 | 1.42e-06 | |||||
The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; This subfamily is composed of proteins of unknown function with similarity to the B subunit of Protocatechuate 4,5-dioxygenase (LigAB). LigAB belongs to the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Dioxygenases play key roles in the degradation of aromatic compounds. LigAB-like enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents the catalytic subunit, B. Pssm-ID: 153386 [Multi-domain] Cd Length: 276 Bit Score: 48.58 E-value: 1.42e-06
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| PCA_45_Dioxygenase_B | cd07364 | Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which ... |
83-196 | 1.81e-06 | |||||
Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Protocatechuate 4,5-dioxygenase (LigAB) catalyzes the oxidization and subsequent ring-opening of protocatechuate (or 3,4-dihydroxybenzoic acid, PCA), an intermediate in the breakdown of lignin and other compounds. Protocatechuate 4,5-dioxygenase is an aromatic ring opening dioxygenase belonging to the class III extradiol enzyme family, a group of enyzmes that cleaves aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon using a non-heme Fe(II). LigAB is composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. The B subunit (LigB) is the catalytic subunit of LigAB. Pssm-ID: 153376 [Multi-domain] Cd Length: 277 Bit Score: 48.16 E-value: 1.81e-06
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| HPCD | cd07370 | The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ... |
80-171 | 3.71e-06 | |||||
The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; 3,4-dihydroxyphenylacetate (homoprotocatechuate) 2,3-dioxygenase (HPCD) catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate (hpca), a central intermediate in the bacterial degradation of aromatic compounds. The enzyme incorporates both atoms of molecular oxygen into hpca, resulting in aromatic ring-opening to yield alpha-hydroxy-delta-carboxymethyl cis-muconic semialdehyde. HPCD is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Pssm-ID: 153382 Cd Length: 280 Bit Score: 47.32 E-value: 3.71e-06
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| Gallate_Doxase_N | cd07950 | The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which ... |
83-173 | 7.85e-06 | |||||
The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Gallate Dioxygenase catalyzes the oxidization and subsequent ring-opening of gallate, an intermediate in the degradation of the aromatic compound, syringate. The reaction product of gallate dioxygenase is 4-oxalomesaconate. The amino acid sequence of the N-terminal and C-terminal regions of gallate dioxygenase exhibits homology with the sequence of PCA 4,5-dioxygenase B (catalytic) and A subunits, respectively. The enzyme is estimated to be a homodimer according to the Escherichia coli enzyme. LigAB-like enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. In this subfamily, the subunits A and B are fused to make a single polypeptide chain. The dimer interface for this subfamily may resemble the tetramer interface of classical LigAB enzymes. Gallate Dioxygenase belongs to the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Pssm-ID: 153387 [Multi-domain] Cd Length: 277 Bit Score: 46.27 E-value: 7.85e-06
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| pcmA | PRK13372 | protocatechuate 4,5-dioxygenase subunit alpha/beta; |
83-173 | 4.41e-05 | |||||
protocatechuate 4,5-dioxygenase subunit alpha/beta; Pssm-ID: 106330 [Multi-domain] Cd Length: 444 Bit Score: 44.63 E-value: 4.41e-05
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| PRK13363 | PRK13363 | protocatechuate 4,5-dioxygenase subunit beta; Provisional |
68-171 | 3.62e-04 | |||||
protocatechuate 4,5-dioxygenase subunit beta; Provisional Pssm-ID: 184002 Cd Length: 335 Bit Score: 41.30 E-value: 3.62e-04
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| 3MGA_Dioxygenase | cd07366 | Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, ... |
72-171 | 1.00e-03 | |||||
Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate; 3-O-Methylgallate Dioxygenase catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate (3MGA) between carbons 2 and 3. 3-O-Methylgallate Dioxygenase is a key enzyme in the syringate degradation pathway, in which the syringate is first converted to 3-O-Methylgallate by O-demethylase. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which uses a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. LigAB-like enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents the catalytic subunit, B. Pssm-ID: 153378 Cd Length: 328 Bit Score: 40.07 E-value: 1.00e-03
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| mhpB | PRK13370 | 3-carboxyethylcatechol 2,3-dioxygenase; |
89-172 | 2.37e-03 | |||||
3-carboxyethylcatechol 2,3-dioxygenase; Pssm-ID: 237366 [Multi-domain] Cd Length: 313 Bit Score: 38.78 E-value: 2.37e-03
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| PRK13366 | PRK13366 | protocatechuate 4,5-dioxygenase subunit beta; Provisional |
83-188 | 3.86e-03 | |||||
protocatechuate 4,5-dioxygenase subunit beta; Provisional Pssm-ID: 184005 Cd Length: 284 Bit Score: 38.24 E-value: 3.86e-03
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| PydA_Rs_like | cd07369 | PydA is a Class III Extradiol ring-cleavage dioxygenase required for the degradation of ... |
85-153 | 4.21e-03 | |||||
PydA is a Class III Extradiol ring-cleavage dioxygenase required for the degradation of 3-hydroxy-4-pyridone (HP); This subfamily is composed of Rhizobium sp. PydA and similar proteins. PydA is required for the degradation of 3-hydroxy-4-pyridone (HP), an intermediate in the Leucaena toxin mimosine degradation pathway. It is a member of the class III extradiol dioxygenase family, a group of enzymes that use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. LigAB-like enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents the catalytic subunit, B. Pssm-ID: 153381 [Multi-domain] Cd Length: 329 Bit Score: 37.95 E-value: 4.21e-03
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