|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
24-401 |
1.04e-147 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 424.37 E-value: 1.04e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 24 WITNFFISASMTMIVPFLSLYIETISPHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSIL 103
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 104 LMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITS 183
Cdd:cd17391 82 LMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 184 FVIFASVLLVLFQVNEQplGEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPV-NLA 262
Cdd:cd17391 162 GLLFLAFLLTLFFVKED--FKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDAsNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 263 FFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIR 342
Cdd:cd17391 240 FISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 494650715 343 VRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
17-402 |
5.35e-86 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 267.56 E-value: 5.35e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 17 KKNFVVIWITNFFISASMTMIVPFLSLYIETISPHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGT 96
Cdd:PRK09874 13 KRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 97 GIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFT 176
Cdd:PRK09874 93 GMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 177 YTFFITSFVIFASVLLVLFQVNE--QPLgekqNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNE 254
Cdd:PRK09874 173 PVFFITASVLFLCFLVTLFCIREnfQPV----SKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 255 LHGPV-NLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGT 333
Cdd:PRK09874 249 LAGNVsNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGAL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494650715 334 LPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWMA 402
Cdd:PRK09874 329 LPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNS 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-401 |
1.02e-54 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 185.47 E-value: 1.02e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 23 IWITNFFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSI 102
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-----GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 103 LLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFI 181
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVwPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 182 TSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVnl 261
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 262 AFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAI 341
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 342 RVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-367 |
1.47e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 147.43 E-value: 1.47e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 16 RKKNFVVIWITNFFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITG 95
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL-----GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 96 TGIAVSILLMGFVTSVYQLFVLRLLMGLVTG-FVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFG 174
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 175 FTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRkqvlsyIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNE 254
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 255 LHGpvNLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTL 334
Cdd:COG2814 237 VLG--LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|...
gi 494650715 335 PCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVL 367
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-401 |
1.20e-34 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 131.55 E-value: 1.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 23 IWITNFFISASMTMIVPFLSLYI-ETISPHSGGYVqrwSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVS 101
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVrEFNKLGASGYY---VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 102 ILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFI 181
Cdd:cd17330 78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 182 TSFVIFASVLLVLFQVneqplgekqnkrktysrkqvlsyifhqPALWAMMVLTMIVQTGNFSIQPLLALYVNELHG--PV 259
Cdd:cd17330 158 AAALALLNLVLVLFFL---------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGfsPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 260 NLA-FFSGMAFSATGLGSLLLARKWGDFGDRfghsRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCIT 338
Cdd:cd17330 211 QIGlLLALVGIAGILAQLLLIPRLAKRLGER----KLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494650715 339 AAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
23-400 |
7.77e-34 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 129.64 E-value: 7.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 23 IWITNFFISASMTMIVPFLSLYIetispHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSI 102
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYA-----HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 103 LLMGFVTSVYQLFVLRLLMGLVTGFVPTSL-AMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFI 181
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAaTLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 182 TSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSyifhqPALWAMMVLTMIVQTGNFSIQPLLALYVNElHGPVNL 261
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE-----KKVLPPALILFLASIAYGAISTFLPLYAAE-RGISNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 262 AFFsgmaFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAI 341
Cdd:cd17489 230 GLF----FTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 342 RVRAPGSIQGEVLG-YNVSFRfLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17489 306 VDLVPPHRRGAANGtFFIFFD-LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
59-402 |
8.44e-30 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 118.87 E-value: 8.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 59 WSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVT-----SVYQLFVLRLLMGLVTGFV-PTSL 132
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFgPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 133 AMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLF-QVNEQPLGEKQNKRKT 211
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFiRRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 212 YSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNEL--HGPVNLAFFSGMAFSATGLGSLLLARkwgdFGDR 289
Cdd:cd06173 195 RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlgGGAAGYGLLLAAFGVGALLGALLLGR----LSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 290 FGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGP 369
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
|
330 340 350
....*....|....*....|....*....|...
gi 494650715 370 LLGGAVSSGFSISAAFYVTAFLFLIGAGLLWMA 402
Cdd:cd06173 351 LLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-401 |
1.49e-29 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 118.06 E-value: 1.49e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 59 WSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISA 137
Cdd:cd17474 35 QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 138 QTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADsFGFTYTFFITSFVIFASVLLVLFQVNEQPlgEKQNKRKTYSRKQV 217
Cdd:cd17474 115 LFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPK--EKAKSSSATKLRDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 218 LSyIFHQPALWAMMVLTMIVQTGNFSIQ---PLLALYVNELHGPVNLAFFSGMAFsATGLGSLLLARKwgdFGDRFGHSR 294
Cdd:cd17474 192 KK-ALRGRGLLTFLVSAFLYFFLYFAFLtylPFLLELLYGISPIIIGLLFAGWSV-LLALGSLFVGRL---LKKRFGARR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 295 ILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGA 374
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL 346
|
330 340
....*....|....*....|....*..
gi 494650715 375 VSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17474 347 LLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-400 |
1.95e-29 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 117.65 E-value: 1.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 22 VIWITNFFISASMTMIVPFLSLYIET--ISPHSggyvqrwSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIA 99
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDfgVSVAQ-------AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 100 VSILLMGFVTSVYQLFVLRLLMGLVTG-FVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYT 178
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGLAHGgFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 179 FFITSFVIFASVLLVLFQVneqPLGEKQNKRKTYSRKQVLSyIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGp 258
Cdd:cd17324 156 FLAIAVLALLAALLLWRLL---PSLPPKKPGSLGLLSSLLL-LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 259 vNLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCIT 338
Cdd:cd17324 231 -FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494650715 339 AAIRVRAPGSiQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17324 310 TRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-369 |
5.63e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.90 E-value: 5.63e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 23 IWITNFFISASMTMIVPFLSLYIETISPHSGGYVqrwsGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSI 102
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 103 LLMGFVTSVYQLFVLRLLMGLVTG-FVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFI 181
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 182 TSFV-IFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSYIFHQPALWAMMVLtMIVQTGNFSIQPLLALYVNELHGPvn 260
Cdd:pfam07690 157 LAILsLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLGLS-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 261 lAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIV---LLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCI 337
Cdd:pfam07690 234 -ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLallLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 494650715 338 TAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGP 369
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
61-403 |
2.27e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 108.80 E-value: 2.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQT 139
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFfPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 140 PKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLvlfqvneqplgekqnkrktysrkqvls 219
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL--------------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 220 yifhqpALWAMMVLTMIVQTGNFSIQPLLALYVNELHG--PVNLAFFSGMAFSATGLGSLLlarkWGDFGDRFGHSR--I 295
Cdd:COG2271 181 ------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGlsLAQAGLLLSLPFLAGIVGSLL----GGWLSDRLGRRRklV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 296 LIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV 375
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
330 340
....*....|....*....|....*...
gi 494650715 376 SSGFSISAAFYVTAFLFLIGAGLLWMAG 403
Cdd:COG2271 331 LDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
17-197 |
2.74e-26 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 108.89 E-value: 2.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 17 KKNFVVIWITNFFISASMTMIVPFLSLYIETISpHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGT 96
Cdd:cd17391 200 PSLLISLFVTTFIIQLANQSIEPILTLYIRQLM-GDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 97 GIAVSILLMGFVTSVYQLFVLRLLMGLVTG-FVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGF 175
Cdd:cd17391 279 ASALLYIPQAFVQTPWQLGILRFLLGLATGgLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGY 358
|
170 180
....*....|....*....|..
gi 494650715 176 TYTFFITSFVIFASVLLVLFQV 197
Cdd:cd17391 359 RAVFVVTALLVLLNAIWSFIFL 380
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
61-401 |
2.84e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.20 E-value: 2.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQT 139
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 140 PKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRkqvLS 219
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD---QL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 220 YIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHG--PVNLAFFSGMAFSATGLGSLLlarkWGDFGDRFGHSRILI 297
Cdd:COG2223 200 EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGlsAATAGLLAALFALLGALGRPL----GGWLSDRIGGRRVLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 298 VLLIASAVFFIPQALAS-SLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVS 376
Cdd:COG2223 276 IVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
330 340
....*....|....*....|....*.
gi 494650715 377 SGF-SISAAFYVTAFLFLIGAGLLWM 401
Cdd:COG2223 356 DATgSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
22-400 |
8.86e-25 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 104.62 E-value: 8.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 22 VIWITNFFISASMTMIVPFLSLYIETISPHSGGYVqrwsGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVS 101
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIV----GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 102 ILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADsFGFTYTFF 180
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFePASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 181 ITSFVIFASVLLVLFQVNEQPLGEKQNKRKtySRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVN 260
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKRRAAEKT--EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 261 LAFfsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFG---MVMGGTLPCI 337
Cdd:cd17329 236 SLL--GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTlgeMLVFPAVQTL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494650715 338 TAAIrvrAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17329 314 VAAL---APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
59-400 |
6.71e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.34 E-value: 6.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 59 WSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISA 137
Cdd:cd06174 32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIdPAVLALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 138 QTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLAD--SFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNK--RKTYS 213
Cdd:cd06174 112 LFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNeeASSKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 214 RKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHG--PVNLAFFSGMAFSATGLGSLLLARKwgdFGDRFG 291
Cdd:cd06174 192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlsVAVAGLLLSLFGLAGALGSLLLGLL---SDRLIG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 292 HSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLL 371
Cdd:cd06174 269 RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348
|
330 340 350
....*....|....*....|....*....|
gi 494650715 372 GGAVSSG-FSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd06174 349 AGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
22-398 |
4.81e-21 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 93.85 E-value: 4.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 22 VIWITNFFISASMTMIVPFLSLYIETISPHSGGyVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVS 101
Cdd:cd17388 3 FILVTVLLDAMGIGLIMPVLPTLLREFVGDSAD-AATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 102 ILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADsFGFTYTFFI 181
Cdd:cd17388 82 YLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 182 TSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQV--LSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYV------N 253
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFgsLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTedrfdwS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 254 ELHGPVNLAFFSGMAFSATGLGSLLLARKWGDfgdrfghSRILIVLLIASAVFFIPQALASslSILLVFRFLFGMVMGG- 332
Cdd:cd17388 241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGE-------KRAILLGLAADALGFLLLAFAT--QGWMVFPILILLALGGi 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 333 TLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLggaVSSGFSISaAFYVTAFLFLIGAGL 398
Cdd:cd17388 312 AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLL---FTGIFAAS-PATWPGLAWIIGAAL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-195 |
3.31e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.48 E-value: 3.31e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 16 RKKNFVVIWITNFFISASMTMIVPFLSLYIEtispHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITG 95
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAA----ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 96 TGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFG 174
Cdd:cd17325 273 LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170 180
....*....|....*....|.
gi 494650715 175 FTYTFFITSFVIFASVLLVLF 195
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-400 |
1.97e-19 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 89.14 E-value: 1.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 25 ITNFFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGI-AVSIL 103
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLVVL-----GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLsALAKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 104 LMGFVTSVYQLFVLRLLMGLVTGF-VPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLL--ADSFGFTYTFF 180
Cdd:cd17370 81 LLALAGSWQLVLLLRILERLGKGIrTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 181 ITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSyifhqPALWAMMVLTMIVQTGNFSIqPLLALYVNELHGPVN 260
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLP-----KAFWLYLLAVALFALGNFSF-AFLILRAQELGLSAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 261 LAFFSGMAFSAT-GLGSLLLARkwgdFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITA 339
Cdd:cd17370 235 LIPLLYALFNLVyALAAYPAGR----LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERA 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494650715 340 AIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17370 311 AVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
45-403 |
2.51e-19 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 88.78 E-value: 2.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 45 IETISPHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLV 124
Cdd:cd17473 22 LPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 125 TGFV-PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADsFGFTYTFFI--TSFVIFASVLLVLFqvneqp 201
Cdd:cd17473 102 VAGImTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVylLALPVLILVLLFLP------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 202 lGEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGpvNLAFFSGMAFSATGLGSLLLAR 281
Cdd:cd17473 175 -EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG--GSAALIGLALAIASLAGAIGAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 282 KWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFR 361
Cdd:cd17473 252 LFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 494650715 362 FLGNVLGPLLGGAVSS-GFSISAAFYVTAFLFLIGAGLLWMAG 403
Cdd:cd17473 332 FLGQFLSPLVLGPLVNlTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
59-399 |
4.29e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 88.02 E-value: 4.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 59 WSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQ 138
Cdd:cd17504 32 AVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 139 TPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVlfqvneqPLgekqnkrktysrkqVL 218
Cdd:cd17504 112 FPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV-------PL--------------ID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 219 SYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYV--NELHGPVNLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRIL 296
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLqlPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 297 IVLLIASAVFFIPQAL-ASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV 375
Cdd:cd17504 251 LIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
330 340 350
....*....|....*....|....*....|..
gi 494650715 376 SSGFSISAAF--------YVTAFLFLIGAGLL 399
Cdd:cd17504 331 LTTYTVSITSggvptegaYVLAFLIGAALALA 362
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
25-400 |
4.34e-19 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 87.99 E-value: 4.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 25 ITNFFISASMTMIVPFLSLYIETISPHSGGYVqrwsGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGT-GIAVSIL 103
Cdd:cd17471 3 LATLLTGLAGAFVLPYLSLFLTEELGASPLQI----GIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALlAGALGYL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 104 LMGFVTSVYQ-LFVLRLLMGLVTGFVPTSLAMI---SAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTF 179
Cdd:cd17471 79 LFAFLRNYWVlLLVGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 180 FITSFVIFASVLLVLFQVNEQPlGEKQNKRKTYSRKQVLSyifhQPALWAMMVLTMIVQTGNFSIQPLLALYV-NELHGP 258
Cdd:cd17471 159 LLAALLYLVVALLVLFLLPSVK-PPAQKATPASSLVKAPV----NRRLLLLFAAFTLLFAANSMYIIAMPLYVtNELGGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 259 VNLAffsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGgtlpcIT 338
Cdd:cd17471 234 ESWV---GLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG-----IT 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494650715 339 AAIRVR-----APGSIQGEVLGYNVSFRfLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17471 306 AGLGISyfqdlMPGQPGLATTLYSNASR-IGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
226-401 |
5.39e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 87.34 E-value: 5.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 226 ALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAffsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAV 305
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA---GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 306 FFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAF 385
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*.
gi 494650715 386 YVTAFLFLIGAGLLWM 401
Cdd:COG2814 168 LVNAVLALLALLLLLR 183
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
23-396 |
1.79e-18 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 86.12 E-value: 1.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 23 IWITNFFISASMTMIVPFLSLYIETISPHSggyvqRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAV-S 101
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASL-----SMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVlA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 102 ILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFI 181
Cdd:cd17490 76 SLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 182 TSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQvlsyiFHQPALWAMMVLTMIVQTGNFSIQ----PLLAlyvNEL-H 256
Cdd:cd17490 156 AALAGVLGFILSLFIKEERREKKPVLTELKELLSV-----LKDKKLLFFSLLAILQQMITFSTTfgftPLIA---KQLgA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 257 GPVNLAFFSGMAFSATGLGSLLLARKwgdFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPC 336
Cdd:cd17490 228 SSFQLGLLSIIYLLPNALASLLSGTL---FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 337 ITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGA 396
Cdd:cd17490 305 LMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAA 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
28-399 |
6.01e-18 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 84.53 E-value: 6.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 28 FFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGF 107
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRLERE-----GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 108 VTSVYQLFVLRLLMGLVTGFVPTSL-AMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLAdsfGFTYTFFITSFVI 186
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG---TAGALPFLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 187 F-ASVLLVLFQVNEQPLGEKQNKRKtysrkqVLSYIFHQPALWAMMVLTMIVQTGNFSiqpLLALYVNELHGPVNLAffs 265
Cdd:cd17477 158 LlLALVPLLLTRRAAPEIEEAESIS------LRRLLRIAPLALLGAFVAGFLEGAFYS---LLPLYGLRLGLSVAQA--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSI-LLVFRFLFGMVMGGTLPCITAAIRVR 344
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLaLLVLLFLWGGAAGPLYTLALALAGDR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 494650715 345 APGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLL 399
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
60-412 |
1.79e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 83.36 E-value: 1.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 60 SGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQT 139
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 140 PKETAGKTLGTLQMGQVSGTLFGPMLGGLLAD---SFGFTYTFFITSFVIFASVLLVLFQvnEQPLGEKQNKRKTYSRKQ 216
Cdd:COG0738 125 GPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRS--KLPEIEEEEEEAAGSAAS 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 217 VLSyIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVnlAFFSGMAFSATgLGSLLLARKWGDF-GDRFGHSRI 295
Cdd:COG0738 203 LKS-LLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLS--EATAALGLSLF-WGGMTIGRFLGGFlLKRFGPVRL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 296 LIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIrVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV 375
Cdd:COG0738 279 LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA-LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
330 340 350
....*....|....*....|....*....|....*..
gi 494650715 376 SSGFSISAAFYVTAFLFLIgagLLWMAGHLQKDTASN 412
Cdd:COG0738 358 ADAFGLRAAFLVPLVCYLL---ILLLALALKRKRRKK 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-403 |
2.06e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 82.99 E-value: 2.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 68 FLMAFVIS-PFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGF-VPTSLAMISAQTPKETAG 145
Cdd:cd17321 40 YLLAFAALlLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 146 KTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFItsFVIFASVLLVLfqvneqplgekqnkrktySRKQVLSYIfhqp 225
Cdd:cd17321 120 RALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI--NVPIGLVALLL------------------ARTFSGAVL---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 226 alwaMMVLTMIVQTGNFSIQPLLALYVNELhgpvnLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAV 305
Cdd:cd17321 176 ----AAFLLGAALGGLLFLLPLYLQGVLGY-----SPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 306 FFIPQAL---ASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSIS 382
Cdd:cd17321 247 GLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSA 326
|
330 340
....*....|....*....|.
gi 494650715 383 AAFYVTAFLFLIGAGLLWMAG 403
Cdd:cd17321 327 NLGDSGVAALLSAAAAAFAAG 347
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
61-401 |
6.19e-17 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 81.88 E-value: 6.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFvPTSLAMISAQTP 140
Cdd:cd17331 38 GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAM-QAAQMVVTDLTD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 141 KETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQV--- 217
Cdd:cd17331 117 PGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSvfn 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 218 ---LSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALY-VNELH-GPVNLAFFSGMAFSATGLGSLLLArkwGDFGDRFGH 292
Cdd:cd17331 197 lkeILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVaMDFFGlTPEENGYLMSYAGVLGMVVQGLLV---GPLTKRFGE 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 293 SRILIVLLIASAVFFIPQALASSLSILLVfrFLFGMVMGGTL--PCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPL 370
Cdd:cd17331 274 RSLLKLSVALLAIGYLLLAFVTTVWQLLV--LLLPLVIGGSVlyTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPT 351
|
330 340 350
....*....|....*....|....*....|.
gi 494650715 371 LGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17331 352 IGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
63-401 |
8.81e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 81.16 E-value: 8.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 63 VFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVT--GFVPTSLAMISAQTP 140
Cdd:cd17355 43 AFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGagTLAAVAFATVAAWWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 141 KETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSY 220
Cdd:cd17355 123 ERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGST 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 221 ---IFHQPALWAMMV-LTMIVQTGNFSIQPLLALYVNELHGPVnlafFSGMAFSATGLGSLLLARKWGDFGDRFGHSRIL 296
Cdd:cd17355 203 lkeALRSASFWLLALaFFLCGFAVVGLIVHLVPYLADRGISPA----AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 297 IVLLIASAVFFIPQALASSLS-ILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV 375
Cdd:cd17355 279 AASYALRALGLALLLLLPFPPlALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
330 340
....*....|....*....|....*..
gi 494650715 376 SSGF-SISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17355 359 YDRTgSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
36-400 |
1.32e-16 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 80.35 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 36 MIVPFLSLYIET--ISPHSGGYVqrwsGYVFGVtflMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQ 113
Cdd:cd17390 14 MILPLLSTHIRSlgASPTVIGLI----GSVYGA---LQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 114 LFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLA-DSFGFTYTFFITSFVIFASVLL 192
Cdd:cd17390 87 LFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAeTDGGFYYVALLCSAIFILNAGL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 193 VLFqvneqplgekqnkrktysrkqVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFSAT 272
Cdd:cd17390 167 VWF---------------------LLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 273 GLGSLLLARKWGDFGDRFGHSRILIVLLIASAvffipqALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGE 352
Cdd:cd17390 226 FLVGRILKLYKNNEYLLLLHSFILLALSLLGL------ALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGT 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 494650715 353 VLGYNVSFRFLGNVLGPLLGGAVSSgFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17390 300 LLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLGAVLALAAILLML 346
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
59-403 |
2.79e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 79.92 E-value: 2.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 59 WSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSL-AMISA 137
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLpGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 138 QTPKETaGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPlGEKQNKRKTYSRKQV 217
Cdd:COG2807 134 WFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP-AAAAAAPAAASLRSL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 218 LsyifHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAffsGMAFSATGLGSLLLARKWGDFGDRFGHSRILI 297
Cdd:COG2807 212 W----RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA---GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 298 VLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQ-GEVLGYNVSFRFLGNVLGPLLGGAVS 376
Cdd:COG2807 285 LLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALH 364
|
330 340
....*....|....*....|....*...
gi 494650715 377 SGF-SISAAFYVTAFLFLIGAGLLWMAG 403
Cdd:COG2807 365 DATgSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
25-400 |
2.00e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 77.63 E-value: 2.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 25 ITNFFISASMTMIVPFLSLYIETISPHSGGYVqrwsGYVFGVTFLMAFVISPFWGRFGDKRG-----YKKILLITGTGIA 99
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGLSAALV----GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 100 VSILLMGFVTSVYQ------LFVLRLLMGLV-TGFVPTSLAMISAQTPKETAGKTLGTLQM-GQVSGTLFGPMLGGLLAD 171
Cdd:COG2211 93 LSFVLLFTAPDLSPtgkliyALVTYLLLGLAyTLVNIPYSALGAELTPDYEERTRLSSWRFaFAGLGGLLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 172 SF------GFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKrktySRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQ 245
Cdd:COG2211 173 AFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV----SLKESLKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 246 PLLALYV-NELHGPVNLAFFSGMAFSATGLGSLLLarkWGDFGDRFGHSRILIVLLIASAVFFIPQALA--SSLSILLVF 322
Cdd:COG2211 249 ALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPL---WPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 323 RFLFGMVMGGTLPCITAAI-------RVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV--SSGFSISAA--------- 384
Cdd:COG2211 326 AALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLlaLFGYVAGAAqspsaltgi 405
|
410 420
....*....|....*....|
gi 494650715 385 ----FYVTAFLFLIGAGLLW 400
Cdd:COG2211 406 rllfFLLPAVLLLLAALLLL 425
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-400 |
3.43e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 76.10 E-value: 3.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 20 FVVIWITNFFISASMTMIVPFLSLYIETISPHSGGYvqrWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIA 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLL---QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 100 VSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTY- 177
Cdd:cd17316 78 LATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 178 ---TFFITSFVIFASVLLvlfqvneqplgekqnkrktysRKQVLsyifhqpALWAMMVLTMIVQTGNFSIQPllALYVNE 254
Cdd:cd17316 158 wriLFLIGALPALLALLL---------------------RRRTL-------LLILLWFFISFGYYGLTTFLP--TYLQTV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 255 LHGPVNLAFFSGMAFSATGLGSLLLarkWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFL-----FGMV 329
Cdd:cd17316 208 LGLSPATSSLYLLLISLGALVGALI---AGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLfilsfFVGG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494650715 330 MGGTLPCITAAI---RVRAPGSiqgeVLGYNVSfRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17316 285 VWGALYAYLAELfptEVRATGV----GLSYNLG-RLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-308 |
3.64e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 75.62 E-value: 3.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 16 RKKNFVVIWITNFFISASMTMIVPFLSLYIETISPHSGGYvqrwsGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITG 95
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL-----GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 96 TGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFG 174
Cdd:COG0477 87 LLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 175 FTYTFFITSFVIFASVLLVLFqvneqpLGEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNE 254
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLR------LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 494650715 255 LHGPVNLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFI 308
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
60-400 |
5.34e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 75.67 E-value: 5.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 60 SGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISaQ 138
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIgSAAFHPEGARLAS-Q 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 139 TPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQvneQPLGEKQNKRKTYSRKQVL 218
Cdd:cd17478 112 AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL---RPLKKPEAKKAAAKSSARS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 219 SYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVnlaFFSGMAFS----ATGLGSLLLARkwgdFGDRFGHSR 294
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSL---VFAGLLLSlflfAGAIGTLIGGP----LSDRFGRRR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 295 ILIVLLIASAVFFIPqALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGS---IQGEVLGYNVSfrfLGNVLGPLL 371
Cdd:cd17478 262 VIIASLLLAAPFLLL-FLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNvglASGLMMGLSFG---LGGIGAPVL 337
|
330 340
....*....|....*....|....*....
gi 494650715 372 gGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17478 338 -GALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
28-400 |
3.08e-14 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 73.77 E-value: 3.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 28 FFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRG-YKKILLITGTGIAVSILLMG 106
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQL-----GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 107 FVTSVYQ-LFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFT--YTFFITS 183
Cdd:cd17335 82 FVAQIFWlLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKnyTIAFYVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 184 FVIFASVLLVLFQVNEQPLGEKQNkrktySRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAf 263
Cdd:cd17335 162 AVLMLLALLLALKFPFRPKHPEPN-----ENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLI- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 264 fsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRV 343
Cdd:cd17335 236 --GLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 494650715 344 RAPGSIQGEVLG-YNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17335 314 AAPPGLRATAQGlLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
77-400 |
4.43e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 73.04 E-value: 4.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 77 FWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQ 155
Cdd:cd17475 50 PAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVqPGGGRAIMRWFPPRERGLAMGIRQTGV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 156 VSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSYIFHqPALWAMMVLTM 235
Cdd:cd17475 130 PLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRN-RDVWLIAIAGA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 236 IVQTGNFSIQPLLALYVNELHG--PVNLAFFSGMAFSATGLGSLLlarkWGDFGDRFGHSR----ILIVLLIASAVFFIP 309
Cdd:cd17475 209 LLVAPQFALLTFLLLFLHDHLGlsVVAAGALLAVAQLGGALGRIG----LGRVSDRVFGGRrrpvLVITAAIAAAALLVL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 310 QALASSLSILLVFR--FLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGP-LLGGAVSSGFSISAAFY 386
Cdd:cd17475 285 SLLSPGTPLWLLVLllILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPpLFGLLVDATHSYAPAWL 364
|
330
....*....|....
gi 494650715 387 VTAFLFLIGAGLLW 400
Cdd:cd17475 365 ALALLLVLAALLLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
61-400 |
5.55e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.60 E-value: 5.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLV-TGFVPTSLAMISAQT 139
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 140 PKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVneqplgekqnkrktysrkqvls 219
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 220 yifhqPALWAMMVLTMIVQTGNFSIQPLLALYVNELHG--PVNLAFFSGMAFSATGLGSLLLARkWGDFGDRFGHSRILI 297
Cdd:cd17319 179 -----RQVWGLALGYFGINYALYGLLTWLPTYLKQARGfsLKQVGLLAAIPFLAGAIGMILGGR-LSDRLLRGARRLVII 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 298 VLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLL-GGAVS 376
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVD 332
|
330 340
....*....|....*....|....
gi 494650715 377 SGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17319 333 ATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-197 |
8.97e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 8.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 28 FFISASMTMIVPFLSLYIETISPHSGGYVqrwsgyvFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGF 107
Cdd:cd17489 204 FLASIAYGAISTFLPLYAAERGISNAGLF-------FTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 108 VTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVI 186
Cdd:cd17489 277 AGSPWMLLLAAVLYGLGFGLLfPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVV 356
|
170
....*....|.
gi 494650715 187 FASVLLVLFQV 197
Cdd:cd17489 357 LLALVLYIFLL 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
227-401 |
2.06e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.04 E-value: 2.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 227 LWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAffsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVF 306
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA---GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 307 FIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFY 386
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170
....*....|....*
gi 494650715 387 VTAFLFLIGAGLLWM 401
Cdd:cd17324 158 AIAVLALLAALLLWR 172
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-199 |
4.09e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 66.13 E-value: 4.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 69 LMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKT 147
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFAlVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 494650715 148 LGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNE 199
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
28-399 |
5.80e-13 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 69.75 E-value: 5.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 28 FFISASMTMIVPFLSLYIETISPHSGGYVQRWSgYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGF 107
Cdd:cd17314 9 FLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIA-TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 108 VTSVYQL-FVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVI 186
Cdd:cd17314 88 VFNSFPLsYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 187 FASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVnlAFFSG 266
Cdd:cd17314 168 AIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDA--PSFVT 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 267 MAFSATGLGSLLLARKWGDFGDRF-GHSRILIVLLI--ASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRV 343
Cdd:cd17314 246 KLMSIYGLFNAFGRLLWGIVADFFgGRLSTLSILLTilGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVST 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 494650715 344 RAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV-SSGFSISAAFYVTAFLFLIGAGLL 399
Cdd:cd17314 326 VFGTESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYIYAVIVFLASAIL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
230-401 |
2.52e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.44 E-value: 2.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 230 MMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAFfsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIP 309
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI--GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 310 QALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTA 389
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|..
gi 494650715 390 FLFLIGAGLLWM 401
Cdd:pfam07690 159 ILSLLAAVLLLL 170
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
28-387 |
5.65e-12 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 66.50 E-value: 5.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 28 FFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGF 107
Cdd:pfam12832 9 FFYFAALGCLLPYWGLYLRSI-----GLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 108 VTSVYQLF-VLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQM---GQVSGTLFGPMLGGLLaDSFGFTYTFFITS 183
Cdd:pfam12832 84 FIPISLTFwWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKDYGRQrlwGSVGFALSVFGLGALF-DHYSVGLLPSVLF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 184 FVIFASVLLVLFQVNEQPLGEKQNKRKTysrKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAf 263
Cdd:pfam12832 163 YLFAALMLLSLLLPLAPPEMEYESKGGS---KAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLL- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 264 fsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAV-FFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIR 342
Cdd:pfam12832 239 --GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALrWLLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVR 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 494650715 343 VRAPGSIQGEVLGYNVSFRF-LGNVLGPLLGGAVSSGFSISAAFYV 387
Cdd:pfam12832 317 RIFPGSLQGTGQALYSGLYFgLGGALGSLIGGQLWDLFGARFTFRA 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
226-401 |
3.17e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 63.68 E-value: 3.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 226 ALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAffsGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAV 305
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL---GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 306 FFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAF 385
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|....*.
gi 494650715 386 YVTAFLFLIGAGLLWM 401
Cdd:COG0477 172 LINAPLGLLALVLRLR 187
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
48-400 |
8.61e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 8.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 48 ISPHSGGYVQrwsgYVFGVTFLmafVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTG 126
Cdd:cd17328 31 IDDSLAGLLQ----TVFIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIgEAS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 127 FVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSF-GFTYTFFITSFVIFASVLLVLFQVNEQPLG-- 203
Cdd:cd17328 104 YSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGaa 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 204 --EKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQ--TGNFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLL- 278
Cdd:cd17328 184 egGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSfvTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLg 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 279 ------LARKWGDFGDRfGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGmvmGGTLPCITAAIrvrAPGSIQGE 352
Cdd:cd17328 264 vllggiLADRLRRKTPR-ADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL---GEFLLSLNWAP---VFAILLYV 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494650715 353 VLGYNVS-----FRFLGNVLG----PLLGGAVSSGF------------SISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17328 337 VIPTRRStasaiQILLSHLLGdagsPYLIGLISDLLrqnkdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
40-399 |
9.82e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.09 E-value: 9.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 40 FLSLYIETISPHsGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRL 119
Cdd:cd17371 17 LLGLVLPALIAE-FGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 120 LMGL-VTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLA----DSFGFTYTFFITSFVIFAsVLLVL 194
Cdd:cd17371 96 LAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLLGALPALL-VLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 195 FQVNEQPL-GEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAFF-SGMAFSAT 272
Cdd:cd17371 175 RFVKEPPQwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEgSAGYLVVT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 273 GLGSLLLARKWGDFGDRFGHSRILIVLLIASAVF-FIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQG 351
Cdd:cd17371 255 ILGGFLGYLAGGFLADRIGRRNNFALFALGSAISiLLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRA 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 494650715 352 EVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAA---FYVTAFLFLIGAGLL 399
Cdd:cd17371 335 TAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAiavFAAVYYIAGLVLALL 385
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
67-401 |
1.57e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.21 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 67 TFLMAFVISP-FWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPT-SLAMISAQTPKETA 144
Cdd:cd17320 42 AYLLGFALGQlLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVvARAIVRDLYSGAEL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 145 GKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPlgeKQNKRKTYSRKQVLSY--IF 222
Cdd:cd17320 122 AKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL---PEEKRKPLLSSLLRAYkrVL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 223 HQPALWAMMVLTMIVQTGNFS-IQPLLALYVNELH-GPVNLAFFSGMAFSATGLGSLLLARkwgdFGDRFGHSRIL---I 297
Cdd:cd17320 199 KNRRFLGYALALGLSFAGLFAyLAAAPFIYIEQLGlSPAQFGLLFALNAIALILGSLLNGR----LVRRFGPRRLLrlgL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 298 VLLIASAVFFIPQALASSLSILLVFRFLFGMVMG-GTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVS 376
Cdd:cd17320 275 LLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGfGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
330 340
....*....|....*....|....*
gi 494650715 377 SGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17320 355 NGTALPMGLLILVLGLLALLLLILL 379
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
61-401 |
2.18e-10 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 62.09 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGI-AVSILLMGFVTSVYQLFVLRLL----MGLVTGFVPTSlAMI 135
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLgVLATAALFFVAPGGLWLGLLLFvlanIGFEGSLVFYN-AFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 136 SAQTPKETAGKTLGT-LQMGQVSGTL---------FGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEK 205
Cdd:COG2270 134 PDIATPEEIGRVSGLgWALGYLGGVLlllinlalfLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 206 QNK----RKTYSR-KQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALY-VNELHGPVN--LAFFSGMAFSAtGLGSL 277
Cdd:COG2270 214 APPrgavRAGFRElRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYaAGVLGFSTTelIVFGLLVQIVA-ALGAL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 278 LLARkwgdFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGtlpcITAAIR---VR-APGSIQGEV 353
Cdd:COG2270 293 LFGR----LDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGG----IQALSRsllARlIPPGREAEF 364
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 494650715 354 LG-YNVSFRFLGnVLGPLLGGAVSSGF-SISAAFYVTAFLFLIGAGLLWM 401
Cdd:COG2270 365 FGlYALSGKAAS-FLGPLLFGLVTQLTgSQRLGILSLIVFFVIGLVLLLR 413
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
34-400 |
7.34e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 60.31 E-value: 7.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 34 MTMIVPFLSLYIETISphsgGYVQRWSGYVFGVTFL-MAFVISPFwGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVY 112
Cdd:cd17472 12 MFLVLPVLSVYAKSLP----GATPTLIGLALGIYGLtQAIFQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 113 QLFVLRLL--MGLVTGFVptsLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASV 190
Cdd:cd17472 87 GLILGRALqgSGAISSVV---MALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 191 LLVLFQVneqplgeKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFS 270
Cdd:cd17472 164 LILLFFV-------PDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 271 ATGLGSLLLARKWGDFGDRFGHSRILIVLLIAS-----AVFFIPQALASSLSILLVFRFLFGMVMGGTLPcitAAIRVRA 345
Cdd:cd17472 237 PAILIGFILMVPFVIYAEKKGKMKQVFVSSILLiavgfLLLLFAATSLWLLIIGLIIFFIGFNLLEALLP---SLVSKIA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 494650715 346 PGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFL---FLIGAGLLW 400
Cdd:cd17472 314 PKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILallWLLVSFLLP 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-195 |
8.97e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 8.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 15 VRKKNFVVIWITNFFISASMTMIVPFLSLYIETIsphsGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLIT 94
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ----FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 95 GTGIAVSILLMGFVT-SVYQLFVLRLLMGLVTGFVPTSL-AMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADS 172
Cdd:COG2223 278 FALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
|
170 180
....*....|....*....|....
gi 494650715 173 FG-FTYTFFITSFVIFASVLLVLF 195
Cdd:COG2223 358 TGsYTAAFLVFAVLALVALVLTLL 381
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-195 |
1.16e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.92 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 15 VRKKNFVVIWITNFFISASMTMIVPFLSLYIETISphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLIT 94
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL----GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 95 GTGIAVSILLMGFV--TSVYQLFVLRLLMGLVTGFV-PTSLAMIS-------AQTPKETAGKTLGTLQMGQVSGTLFGPM 164
Cdd:COG2211 301 LLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAIlVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGA 380
|
170 180 190
....*....|....*....|....*....|.
gi 494650715 165 LGGLLADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:COG2211 381 LAGLLLALFGYVAGAAQSPSALTGIRLLFFL 411
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
76-400 |
2.83e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 58.36 E-value: 2.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 76 PFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGF-VPTSLAMISAQTPKETAGKTLGTLQMG 154
Cdd:cd17503 49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 155 QVSGTLFGPMLGGLLADSFGFTYTFFI-TSFVIFASVLLVLFQVNeqplgekqnkrktysrkqvlsyIFHQPALWAMMVL 233
Cdd:cd17503 129 ILLAPAIGPTLGGWLTDNLSWRWIFYInLPIGILALLLAPLLDLR----------------------LFKDRNFTLGLLL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 234 TMIVQTGNFSIQPLLALYVNELHGPVnlAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALA 313
Cdd:cd17503 187 SFLLGLGLFGAMFLLPLYLQNVLGYS--AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 314 ---SSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV--------------- 375
Cdd:cd17503 265 tpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLltnrtqfhhsrlsel 344
|
330 340 350
....*....|....*....|....*....|...
gi 494650715 376 --------SSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17503 345 laqqvqkqALIIAFNDAFLVSAILLLVGLLLAL 377
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
266-401 |
2.84e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 55.35 E-value: 2.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRA 345
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 346 PGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
79-399 |
3.23e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.98 E-value: 3.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 79 GRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAGkTLGTLQMgqvS 157
Cdd:cd17365 55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRRS-LAVTLMF---C 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 158 GTLFGPMLGGLLA----DSFGFTYTFFITSFVIFASVLLVLFQVneqplgekqnkrktysrkqvlsyifhqpALWAMMVL 233
Cdd:cd17365 131 GYPLGAALGGFLAaaliPAFGWRSVFLLGGVPPLILLPLLRGTL----------------------------LLWVTFFM 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 234 TMIVQTGNFSIQPLLalyVNELHGPVNLAFFSGMAFSATG-LGSLLLARkwgdFGDRFGHSRILIVLLIASAVFFIPQAL 312
Cdd:cd17365 183 GLLLVYLLNSWLPKL---MVEAGYSLSQALTITLLLNIGGvIGSLLLGW----LADRFGPKRVLALFFALGAVSLALLGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 313 AS-SLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGA-VSSGFSISAAFYVTAF 390
Cdd:cd17365 256 SPaSLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAGLGPESVFLALAI 335
|
....*....
gi 494650715 391 LFLIGAGLL 399
Cdd:cd17365 336 PAALGALAV 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-155 |
3.85e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.68 E-value: 3.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 15 VRKKNFVVIWITNFFISASMTMIVPFLSLYIETISphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLIT 94
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL----GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494650715 95 GTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQ 155
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLfPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
61-399 |
3.95e-09 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 58.00 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGyKKILLITGTGIA-VSILLMGFV-----TSVYQL--FVLRLLMGL-VTGFVPTS 131
Cdd:cd17385 37 GLVFGCFALVIFLTSPIFGKYLVKIG-AKFMFVAGMFVSgGCTILFGFLdrvpdGTVFIAlcFLVRIVEAVgFAAFITAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 132 LAMISAQTPKETAgKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVneqPLGEKQNKRKT 211
Cdd:cd17385 116 FAIIAKEFPNNIA-TVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFIL---PRYDDDPSPKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 212 YSRKQVLsyifhqpALWAMMVLTMIVQTGNFSI---QPLLALYVNELHGPVNLAffsGMAFSATGLGSLLLARKWGDFGD 288
Cdd:cd17385 192 GSMLKLL-------KIPSVLLLCLSIVSGSVSLgflDPTLSPHLRQFKLSPGQV---GLMFLILAGSYAISAPLWGWLSD 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 289 RFGHSRILIVL-LIASAVFFI------PQALASSLSILLVFRFLFGMVMGGTL-PCITAAIR-VRAPG-----SIQGEVL 354
Cdd:cd17385 262 KKKIPKWLMVIgSIITGVGFLllgpapLLPIKSELWMVIIGLVLLGLSLGAALvPTFPELLNcAREYGfpdnlSTYGLVS 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 494650715 355 GYNVSFRFLGNVLGPLLGGAVSS--GFSISAAFyVTAFLFLIGAGLL 399
Cdd:cd17385 342 GLFNAAFSLGAFIGPTLGGFLLErlGFEWAATI-QAGLAFVVGILMS 387
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
266-401 |
5.46e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.58 E-value: 5.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRA 345
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 346 PGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
61-373 |
1.73e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.21 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQT 139
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 140 PKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITS-------------------FVIFASVLLVLFQVN-- 198
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGiaplllllllmrflpesidFLVSKRPETVRRIVNai 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 199 ------EQPLGEKQNKRKTYSRKQVLSYIFHQ------PALWAMMVLTMIVQTGNFSIQPLLalyVNELHGPVNLAFFSG 266
Cdd:TIGR00895 215 apqmqaEAQSALPEQKSTQGTKRSVFKALFQGktaritVLLWLLYFMLLVGVYFLTNWLPKL---MVELGFSLSLAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 267 MAFSATG-LGSLLLARkwgdFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRA 345
Cdd:TIGR00895 292 ALFNFGGvIGSIIFGW----LADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFY 367
|
330 340
....*....|....*....|....*...
gi 494650715 346 PGSIQGEVLGYNVSFRFLGNVLGPLLGG 373
Cdd:TIGR00895 368 PTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
60-395 |
2.19e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 55.26 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 60 SGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQ 138
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIgGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 139 TPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFIT-SFVIFASVLLvlfqvneqplgekqnkrktysrkqv 217
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINlPIGGLALALL------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 218 lsyifhqPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGpvNLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILI 297
Cdd:cd17502 167 -------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLG--DSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 298 V----LLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVlgplLGG 373
Cdd:cd17502 238 VigtiLMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGT----LGV 313
|
330 340
....*....|....*....|..
gi 494650715 374 AVSSGFSISAAFYVTAFLFLIG 395
Cdd:cd17502 314 AITDVFLVALALAALAFLLSLF 335
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
65-396 |
3.32e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 55.70 E-value: 3.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 65 GVTFLMAFVI-SPFWGRFGDKRGYKKILLIT---GTGIAVSILLMGFVTSVYQLFVLRLLMGLVTG-FVPTSLAMISAQT 139
Cdd:PRK08633 53 NALFLLPFLLlSSPAGFLADKFSKNRVIRIVklfEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAiYSPAKYGIIPELV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 140 PKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNE----------QPLGEKQNKR 209
Cdd:PRK08633 133 GKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILGRIAPAGLVLLAVAVLGlifayrlpkvPAAAPEVFDK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 210 KTYSR----KQVLSYIFHQPALW-AMMVLTMIVQTGNFSIQPLLALYVNELHgpVNLAFFSGM--AFSATG--LGSLLLA 280
Cdd:PRK08633 213 KKYLFpkllWRNLKLLRSDRVLWlAIIGLSYFWFISQLAQANFPAYAKEVLG--LDNTFQVQYllAASAIGigIGSLLAG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 281 RKWGDfgdrfgHSRILIVLL----IASAVFFIPQAlaSSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGY 356
Cdd:PRK08633 291 RLSGR------HIELGLVPLgalgLALSLFLLPTA--PSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAA 362
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 494650715 357 NVSFRFLGnVLGPLLGGAVSSGFSISAA--FYVTAFLFLIGA 396
Cdd:PRK08633 363 NNFLQNVG-MLLFLALTTLFSGLGLSPAglFYLIALVTLIGT 403
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
69-399 |
1.67e-07 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 53.05 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 69 LMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSvYQLFVL-RLLMGLVTGFVPTSLAMISAQTPKETAGKT 147
Cdd:cd17389 75 LLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRS-FTIFLLsRIVGGISKGNVSLSTAIVADVTSPKKRSKG 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 148 LGTLQMGQVSGTLFGPMLGGLLADsfgFTYTFFITSFVIFASVLLVLFQVNeqplgekqnkrktysrkQVLSYIFHQPAL 227
Cdd:cd17389 154 MALIGVAFSLGFIIGPMIGAYFAS---FTRSLGEVFFSMPALFALVLALAD-----------------LLFIFFFLPETL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 228 WAMMVLTMIVqtgNFsiqpllaLYvnelhgpvnLAFFSGMAFSATGLG------------------SLLLARKWGDFGDR 289
Cdd:cd17389 214 PSNLRRLGLV---YF-------LY---------LFLFSGLEFTLTFLThqrfqytsmqqgkmfffiGIIMALVQGGYVRR 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 290 FGHSRIL------IVLLIASavfFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFL 363
Cdd:cd17389 275 IKPGKEKkavlqgLILLIPA---FLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGAL 351
|
330 340 350
....*....|....*....|....*....|....*.
gi 494650715 364 GNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLL 399
Cdd:cd17389 352 ARALGPIVACTVYWLAGSEACYTIGALLFLLPLLLL 387
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
61-398 |
2.27e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.32 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTP 140
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 141 KETAGKTLGTLQMGQVSGTLFGPMLGG-LLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLS 219
Cdd:cd17333 114 EESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASAS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 220 YIFHQPALWAMMV---LTMIVQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFSATgLGSLLLARkwgdFGDRFGHSRIL 296
Cdd:cd17333 194 RLLRNPSIILGALalfLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGIT-IGRLLGGP----ISRRIKPHTLL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 297 IVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSiQGEVLGYNVSFRFLGNVLGPLLGGAVS 376
Cdd:cd17333 269 VLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
330 340
....*....|....*....|..
gi 494650715 377 SGFSISAAFYVTAFLFLIGAGL 398
Cdd:cd17333 348 EAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
64-331 |
2.99e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 52.14 E-value: 2.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 64 FGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQ--------LFVLRLLMGL-VTGFVPTSLAM 134
Cdd:cd17369 50 FGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLaLGGEWGGAVLM 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 135 ISAQTPKETAGKTLGTLQMGQVSGTLFGP----MLGGLLADSFGFTYTF---FITSFVIFASVLLVLFQVNEQPLGEKQN 207
Cdd:cd17369 130 AVEHAPPKRRGFYGSFPQLGAPVGLLLATgvflLLSALLSDEAFLSWGWripFLLSAVLVAVGLYIRLRLEETPVFRRAK 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 208 KRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALY--VNELHGPVNLAFFSGMAFSATGLGSLLLarkWGD 285
Cdd:cd17369 210 EAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSyaTQTLGVDRSTVLLAVLIASVVAAITIPL---FGW 286
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 494650715 286 FGDRFGHSRILIVLLIASAVFFIP--QALASSLSILLVFRFLFGMVMG 331
Cdd:cd17369 287 LSDRVGRRPVYLAGALLAALFAFPffWLLDTGSTWLIVLAAVVVLGVL 334
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
242-400 |
3.66e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.66 E-value: 3.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 242 FSIQPLLALYVNELHGPvnlAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLV 321
Cdd:cd06174 13 GLISPLLPALLQSFGLS---ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 322 FRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSIS--AAFYVTAFLFLIGAGLL 399
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAAALALLAAILL 169
|
.
gi 494650715 400 W 400
Cdd:cd06174 170 L 170
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
81-197 |
4.90e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 4.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 81 FGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQ-TPKETAGKTLGTLQMGQVSGT 159
Cdd:cd17490 254 FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEgVPAEQRSTAMGFFQAIYALGM 333
|
90 100 110
....*....|....*....|....*....|....*...
gi 494650715 160 LFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQV 197
Cdd:cd17490 334 FLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
29-203 |
6.32e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 51.04 E-value: 6.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 29 FISASMTMIVPFLSLYIETIsphsggyvqrWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFV 108
Cdd:cd17315 15 VINGALLYIAKDLGFGLSTS----------LQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 109 TSVYQLFVLRLLMGLVTGFVPTSLAM-ISAQTPKETAGkTLGTL-QMGQVSGTLFGPMLGGLLADSF--GFTYTFFITSF 184
Cdd:cd17315 85 PNVWVLIVGRFLLGLGVGLASVLVPLyISEIAPAKIRG-ALGTLnQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAV 163
|
170
....*....|....*....
gi 494650715 185 VIFASVLLVLFQVNEQPLG 203
Cdd:cd17315 164 PALLQLLLMFFLPESRALL 182
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-195 |
6.47e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.04 E-value: 6.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 16 RKKNFVVIWITNFFISASMTMIVPFLSLYIETISPHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITG 95
Cdd:cd17504 175 RRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 96 TGIAVSILLMGFV-TSVYQLFVLRLLMGLVTGFVPTSLA-MISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSF 173
Cdd:cd17504 255 VISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPnIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTY 334
|
170 180 190
....*....|....*....|....*....|....*
gi 494650715 174 -------------GFTYTFFITSFVIFASVLLVLF 195
Cdd:cd17504 335 tvsitsggvptegAYVLAFLIGAALALAALLLSLL 369
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
244-401 |
8.56e-07 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 50.69 E-value: 8.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 244 IQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDfgdRFGHSRILIVLLIASAVFFIPQALASSLSILLVFR 323
Cdd:cd17390 15 ILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSD---VVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 324 FLFGmVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAV---SSGFSISAafYVTAFLFLIGAGLLW 400
Cdd:cd17390 92 IPLG-IFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLaetDGGFYYVA--LLCSAIFILNAGLVW 168
|
.
gi 494650715 401 M 401
Cdd:cd17390 169 F 169
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
61-210 |
1.13e-06 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 50.39 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTS-LAMISAQT 139
Cdd:cd17383 33 GVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAgLAMIADRF 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494650715 140 PKETA-GKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRK 210
Cdd:cd17383 113 TEEAErSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMPE 184
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
266-335 |
1.44e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.96 E-value: 1.44e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLP 335
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALP 122
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
67-399 |
1.64e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.58 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 67 TFLMAFVISPF-WGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLV--TGFVPTSLAMISAQTPKET 143
Cdd:cd17312 46 AFLIAYAVGKFiSGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFqsMGWPPCVKLLGNWFSKKER 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 144 AGKTlGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPlgekqnkrktysrkqvlsyifh 223
Cdd:cd17312 126 GTVY-GIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP---------------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 224 qPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGP--VNLAFFSG---MAFSATGLGSLLLARKWGDfGDRFGHSRILIV 298
Cdd:cd17312 183 -PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYslIDAGWFSSlyeVGGIAGTILAGLLSDKLFG-GRRAPIAVIYML 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 299 LLIASAVFFIPQALASSLSILLVfrFLFGMVMGGTLPCITAAIRVRAPGS-IQGEVLGYNVSFRFLGNVLGPLLGGAVSS 377
Cdd:cd17312 261 LMTLSLALFWFFPHNKLLSIVLL--FLIGFFVGGPINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIID 338
|
330 340
....*....|....*....|..
gi 494650715 378 GFSISAAFYVTAFLFLIGAGLL 399
Cdd:cd17312 339 HYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
91-399 |
1.78e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 50.13 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 91 LLITGTGIAVSILLMGFVtSVYQLFVLRLLMGLVTGF-VPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLL 169
Cdd:pfam05977 84 LLALVSTLLTLLAGLGLL-SPWLLLGLTFLGGIGTALmDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 170 ADSFGFTYTFFITSFVIFAsVLLVLFQ----VNEQPLGEKQNKRKTYSRkqvLSYIFHQPALWAMMVLTMIVQTGNFSIQ 245
Cdd:pfam05977 163 LAAFGPAFTFALNALSYFA-VIAALWRwkraAPASPLPRERIFGAVRAG---LRFTAMSRELRSVLVRAFAFGLSASAVW 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 246 PLLALYV-NELHGPvnlAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRF 324
Cdd:pfam05977 239 ALLPLVArDLLDGD---AIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLL 315
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494650715 325 LFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLL 399
Cdd:pfam05977 316 LGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAG 390
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
77-372 |
1.82e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 49.69 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 77 FWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAGKTLGTLQMGQ 155
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFgASAGSVISQALVRDIYPGEELSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 156 VSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRkqVLSYIFHQPALWAMMVLTM 235
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFE--TFLLLLKSKMFWGYALIYG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 236 IVQTGNF---SIQPLlaLYVNELHGPVN----LAFFSGMAFSATGLGSLLLARKWGDFGDRfghsRILIVLLIASAVFFI 308
Cdd:TIGR00710 217 ASFGGFFaffSGAPF--VYIDIMGVSPSvfglLFALNIIAMIFGGFLNGRFIKKWGAKSLL----RMGLILFAVSAVLLE 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 309 PQALASSLSILLVFR-FLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRF-LGNVLGPLLG 372
Cdd:TIGR00710 291 ITAILGLGSWAMIIGpMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRLvLGAIVGYLVS 356
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
60-400 |
2.07e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.53 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 60 SGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLF-VLRLLMGLVTGFV-PTSLAMISA 137
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFlGYGVLGGIGAGIGyITPVSTAVK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 138 QTPKETAGKTlGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGE-------KQNKRK 210
Cdd:cd17353 120 WFPDKRGLAT-GIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWvppgvdpLANNAE 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 211 TYSRKQVLSYIFHQPALWAM-MVLTMIVQTGNFsIQPLLALYVNELHG--PVNLAFFSGMAFSATGLGSLLlarkWGDFG 287
Cdd:cd17353 199 NSPRDYTPREMLRTPTFWLLwLMFFLNATAGLM-LIGQAKPIGQEFAGldAGIAALAVSILSIFNGGGRPF----WGWLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 288 DRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRF-LFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNV 366
Cdd:cd17353 274 DKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVaLIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGL 353
|
330 340 350
....*....|....*....|....*....|....
gi 494650715 367 LGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17353 354 IGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
284-405 |
2.08e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 49.48 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 284 GDFGDRFGHSRILI--VLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFR 361
Cdd:cd17380 55 GYLADRFGGKKVLLlaVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 494650715 362 FLGNVLGPLLGGAVSSGFSISAAFYVTAFLfligaGLLWMAGHL 405
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLL-----GLLWALVWL 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
266-401 |
2.65e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRA 345
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 346 PGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWM 401
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMR 190
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
66-195 |
3.04e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 49.11 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 66 VTFLMAFVISP-FWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGlVTGFVPTSL--AMISAQTPKE 142
Cdd:cd17323 41 SLFVLGFGLGPlIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQG-FFGSSPLAIgaGTIADLFTPE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 494650715 143 TAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:cd17323 120 ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFL 172
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
36-329 |
4.31e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 48.77 E-value: 4.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 36 MIVPFLSLYIETISPHSGGYVQRWSGYVF-GVTFLM-------------------------AFVISPFWGRF----GDKR 85
Cdd:PRK12307 1 MIAKFFPWYSEITRPQKNALFSAWLGYVFdGFDFMLifyimylikadlgltdmegaflataAFIGRPFGGALfgllADKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 86 GYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAGKTLGTLqmgqVSGTLFGPM 164
Cdd:PRK12307 81 GRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMgMAGEYACASTYAVESWPKHLKSKASAFL----VSGFGIGNI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 165 LGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRK-------TYSRKQVLSYIFHQPALWAMMVLTMIV 237
Cdd:PRK12307 157 IAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgkgkhSQSAWSVFSLSMKGLFNRAQFPLTLCV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 238 QTGNFSI----QPLLALYVNELHGP-VNLAFFSGMaFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQAL 312
Cdd:PRK12307 237 FIVLFSIfganWPIFGLLPTYLAGEgFDTGVVSNL-MTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFR 315
|
330
....*....|....*..
gi 494650715 313 ASSLSILLVFRFLFGMV 329
Cdd:PRK12307 316 IPQDNYLLLGACLFGLM 332
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
69-392 |
5.01e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.40 E-value: 5.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 69 LMAFVISPFWGRFGDKRGYKKILLITgtgIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTL 148
Cdd:cd17341 49 LLRLPYGFLCDRFGGRRVFIASLLLL---LIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 149 GTL----QMGQVSGTLFGPML---GGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGekqnKRKTYSRKQVLSYI 221
Cdd:cd17341 126 GGIagagNMGVAVSQLLAPLIagaIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG----KASALEFLKVQLAV 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 222 FHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGpVNLAFFSGMAFSATGLGSLLLArKWGDFGDRFGHSRILIVLLI 301
Cdd:cd17341 202 LKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFG-LPLVTAGILAALFPLAGALARP-AGGWLSDRFGGRRRLWWLFI 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 302 ASAVFFI-----PQALASSLSILLVFRFLFGMVMG---GTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVL---GPL 370
Cdd:cd17341 280 VMTIGAAllslsLPTSGTNLVLFLALFVALGLGAGagnGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLfgsSAL 359
|
330 340
....*....|....*....|..
gi 494650715 371 LGGAVSSGFSISAAFYVTAFLF 392
Cdd:cd17341 360 MTGSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-195 |
6.18e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.96 E-value: 6.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 18 KNFVVIWITNFFISASMTMIVPFLSLYIETISphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTG 97
Cdd:cd17503 178 RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVL----GYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 98 IAVSILLMGFV---TSVYQLFVLRLLMGLVTGFVPTSLAMISAQT-PKETAGK---------------------TLGTLQ 152
Cdd:cd17503 254 LALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSlPPEQIGDatalfntirqlggsigtallaTLLTNR 333
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 494650715 153 MGQVSGTLFGPMLGGLL--ADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:cd17503 334 TQFHHSRLSELLAQQVQkqALIIAFNDAFLVSAILLLVGLLLALF 378
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
36-398 |
9.35e-06 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 47.36 E-value: 9.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 36 MIVPFLSLYIEtispHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVS--------ILLMGF 107
Cdd:PRK12382 33 LPLPVIPLFVH----HDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAglayllaaILPVSA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 108 VTSVYQLFVLRLLMG-----LVTGFVPTSLAMISAQtpkeTAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFIT 182
Cdd:PRK12382 109 PFKFALLVVGRLILGfgesqLLTGALTWGLGLVGPK----HSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGFAALALTT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 183 sfvIFASVLLVLFQVNEQPLGEKQNKRKtySRKQVLSYIFhQPALWAMMVLTMIVQTGNFSiqpllALYVNELHGPvnla 262
Cdd:PRK12382 185 ---MVLPLLAWAFNGTVRKVPAHAGERP--SLWSVVGLIW-KPGLGLALQGVGFAVIGTFV-----SLYFASKGWA---- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 263 fFSGMAFSATGlGSLLLARK-WGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAI 341
Cdd:PRK12382 250 -MAGFTLTAFG-GAFVLMRVlFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEV 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 494650715 342 RVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGL 398
Cdd:PRK12382 328 VKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIV 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
16-195 |
1.64e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.83 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 16 RKKNFVVIWITNFFISASMTMIVPFLSLYIETISPHSGGYVqrwsgyVFGVTFLMAFVIS--PFWGRFGDKRGYKKILLI 93
Cdd:cd17353 211 RTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIA------ALAVSILSIFNGGgrPFWGWLSDKIGRKNTLSI 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 94 TGTGIAVSILLMGFVTSVYQLFVLrlLMGLVTGFVPTSLAMISAQTPK----ETAGKTLGTLQMGQVSGTLFGPMLGGLL 169
Cdd:cd17353 285 AFLIQGVAMFLLPFIGSVAVLFVL--GVALIGFCYGGGFALFPALTADffgtKNAGTNYGLLYTAKGVGGLIGPIIAAYV 362
|
170 180
....*....|....*....|....*.
gi 494650715 170 ADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:cd17353 363 LYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
231-409 |
1.67e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.40 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 231 MVLTMIVQTGNFSIQPLLALYVNELHGPvnlAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQ 310
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVS---TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 311 ALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSgfSISAAFYVTAF 390
Cdd:cd17477 79 ALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT--AGALPFLIAAV 156
|
170
....*....|....*....
gi 494650715 391 LFLIGAGLLWMAGHLQKDT 409
Cdd:cd17477 157 LLLLALVPLLLTRRAAPEI 175
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
225-392 |
1.83e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 46.61 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 225 PALWAMMVLTMIVQTGNF----SIQPLLALYVN-ELH---GPV-NLAFFSGMAFSAtglGSLLLarkwGDFGDRFGHSR- 294
Cdd:PRK03893 271 GKRWPTGVMLMVVVLFAFlyswPIQALLPTYLKtDLGydpHTVaNVLFFSGFGAAV---GCCVG----GFLGDWLGTRKa 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 295 ----ILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAA---IRVRAPGsiqgevLGYNVSFRFLGNVL 367
Cdd:PRK03893 344 yvcsLLISQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGyfdTEQRAAG------LGFTYNVGALGGAL 417
|
170 180
....*....|....*....|....*
gi 494650715 368 GPLLGGAVSSGFSISAAFYVTAFLF 392
Cdd:PRK03893 418 APILGALIAQRLDLGTALASLSFSL 442
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
266-400 |
2.18e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.04 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRA 345
Cdd:cd17365 37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYA 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494650715 346 PGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17365 117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
27-174 |
3.02e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.11 E-value: 3.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 27 NFFISASMTMIVPFLSLYIETISPHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMG 106
Cdd:pfam00083 15 DTGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQG 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494650715 107 FVT---SVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFG 174
Cdd:pfam00083 95 AAKgkwSVYQLIVGRVLVGIgVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSN 166
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
15-195 |
3.19e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 15 VRKKNFVVIWITNFFISASMTMIVPFLSLYIETISPHSGGyvqrwSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLIT 94
Cdd:cd17472 191 LKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQ-----LWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVS 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 95 G-TGIAVSILLMGFVTSVYQLFVLrLLMGLVTGFV---PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLA 170
Cdd:cd17472 266 SiLLIAVGFLLLLFAATSLWLLII-GLIIFFIGFNlleALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
|
170 180
....*....|....*....|....*
gi 494650715 171 DSFGFTYTFFiTSFVIFASVLLVLF 195
Cdd:cd17472 345 GLLGYSSVFL-TILILALLWLLVSF 368
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
63-195 |
3.27e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 45.57 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 63 VFGVTFLMAFVISPFWGRFGDKRGYKK-ILLITGTGIAVSILLMGFVTSVYQ------LFVLRLLMGLVTGFVPTSlAMI 135
Cdd:cd17337 249 IWGIIFLVNIFFNLIFGILGDKIGWRRtVRWFGGVGCAISTLLFYYVPQLFGhnywaaLIAAILFGIGLAGFVPLS-ALM 327
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 136 SAQTPKETaGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:cd17337 328 PSLAPEHK-GAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTLF 386
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
63-309 |
4.22e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 45.36 E-value: 4.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 63 VFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGfVTSVYQ---------LFVLRLLMGL-VTGFVPTSL 132
Cdd:cd17367 45 VFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIA-VTPTYAtigiwapiiLLLARLLQGLsVGGEYGTSA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 133 AMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLAD--------SFGFTYTFFITSfvIFASVLLVLFQVNEQPLGE 204
Cdd:cd17367 124 TYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWRIPFLLGG--VLAVVVLWLRRGLEETESF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 205 KQNKRKTYSRKQVLSYIFHQP-ALWAMMVLTMIVQTGNFSIQPLLALY-VNELHGPVNLAFFSGMafsATGLGSLLLARK 282
Cdd:cd17367 202 EAIAESNEASAGTLRELRRHPrELLLVVGLTAGGTLAFYTWTTYLQKFlVNTAGFSKGDATWITT---AALLVFMLLQPL 278
|
250 260
....*....|....*....|....*..
gi 494650715 283 WGDFGDRFGHSRILIVLLIASAVFFIP 309
Cdd:cd17367 279 GGRLSDRIGRRPLLLFFGIGGTLATVP 305
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
54-402 |
4.54e-05 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 45.26 E-value: 4.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 54 GYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGF--------VTSVYQLFVLRLLMGLVT 125
Cdd:PRK05122 47 GFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLagllaawpVLSLLLLLLGRLLLGIGE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 126 GFVPTslAMIS---AQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPL 202
Cdd:PRK05122 127 SLAGT--GSILwgiGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLLIMLLALLGLLLARPRPAVPPV 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 203 GEkqnKRKTYSRkqVLSYIFHQPALWAMmvltmivQTGNF-SIQPLLALYVNELHGPVnlAFFSGMAFSATGLGSLLLar 281
Cdd:PRK05122 205 KG---ERLPFRR--VLGRVWPYGMGLAL-------ASIGFgTIATFITLYYAARGWDG--AALALTLFGVAFVGARLL-- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 282 kWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCI-TAAIRvRAPGSIQGEVLGYNVSF 360
Cdd:PRK05122 269 -FGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALgVEAVK-RVPPQNRGAALGAYSVF 346
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 494650715 361 RFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLWMA 402
Cdd:PRK05122 347 LDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLL 388
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-195 |
5.34e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.87 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 18 KNFVVIWITNFFISASMTMIVPFLSLYIEtispHSGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTG 97
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLK----QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 98 IAVSILLMGFVTSVYQLFVLRLLMGLVTGFV----PTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSF 173
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIgaasPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAT 334
|
170 180
....*....|....*....|...
gi 494650715 174 G-FTYTFFITSFVIFASVLLVLF 195
Cdd:cd17319 335 GsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
156-335 |
6.09e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.90 E-value: 6.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 156 VSGTLFGPMLGGLLAD--SFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKrKTYSRKQVLSYIFHQPALWAMMVL 233
Cdd:cd17332 151 LVTVLPPPLVAYFGGGnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEK-SKLPLLKSLKALLKNRPFLILLLA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 234 TMIVQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLarkWGDFGDRFGHSRILIVLLIASAVFFIPQALA 313
Cdd:cd17332 230 YLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLP---WPPLKKRFGKKKAFFIGLLLAILGLLLLFFL 306
|
170 180
....*....|....*....|....
gi 494650715 314 SSLSI--LLVFRFLFGMVMGGTLP 335
Cdd:cd17332 307 PPGNLvlILVLAVLAGIGYGGANL 330
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
233-400 |
7.47e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.49 E-value: 7.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 233 LTMIVQTGNFSIQPLLALYVNELHGPVNLAFFS-GMAFSATGLGSLLlarkWGDFGDRFGHSRILIVLLIASAVFFIPQA 311
Cdd:cd17323 7 LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGvSLFVLGFGLGPLI----WAPLSELYGRRPVYLVSLFIFVIFQIGCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 312 LASSLSILLVFRFLFGM-------VMGGTLPCITAAIRVrapgsiqGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAA 384
Cdd:cd17323 83 LAPNIAMLIILRFLQGFfgssplaIGAGTIADLFTPEER-------GKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWI 155
|
170
....*....|....*.
gi 494650715 385 FYVTAflflIGAGLLW 400
Cdd:cd17323 156 FWFLA----IISGFCL 167
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
227-399 |
7.58e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.49 E-value: 7.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 227 LWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAFFS-GMAFSATGLGSLLlarkWGDFGDRFGHSRILIVLLIASAV 305
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTlSAYLLGFALGQLL----YGPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 306 FFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAF 385
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF 156
|
170
....*....|....
gi 494650715 386 YvtaFLFLIGAGLL 399
Cdd:cd17320 157 V---FLALLGLLLL 167
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
67-201 |
9.92e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 44.33 E-value: 9.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 67 TFLMAFVISPFwGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMI-SAQTPKETA 144
Cdd:PRK14995 51 SLVMAGMVLPM-GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIgAAMIVPATLAGIrATFTEEKQR 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 494650715 145 GKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQP 201
Cdd:PRK14995 130 NMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQA 186
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
63-347 |
1.15e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 43.90 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 63 VFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSvYQ---------LFVLRLLMGLVTG--FVPTS 131
Cdd:cd17368 45 TFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPT-YAtigiaapllVLLARLLQGFAAGgeVGGVT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 132 LAMISAQTPKETAgkTLGTLQM-GQVSGTLFGPMLGGLLA--------DSFGFTYTFFITSFVIfaSVLLVLFQVNEQPL 202
Cdd:cd17368 124 AYLVEAAPPGRRG--FYTSWQSaSQQVAIVAGALVGYLLSltltaealAEWGWRIPFFIGLLII--PLGLWLRRSLEETE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 203 GEKQNKRKTYSRKQVLSYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNE-LHGPVNLAFFSGMAFSATGLGSLLLAr 281
Cdd:cd17368 200 AFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTvLGLSARDSFLVTLLAGVANFIWAPLG- 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 282 kwGDFGDRFGHSRILIVLLIASAVFFIP--QALASS------LSILLVFRFLFGMVMGGTLPCITAA--IRVRAPG 347
Cdd:cd17368 279 --GALSDRIGRRPVLLVITLAALVTLYPvfAWLTAApsfgrlLLVLLVLSFFFGMYGGAMVVALVELfpVRVRSTG 352
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
77-222 |
1.95e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 43.36 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 77 FWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLvtgFVPTSLAMISAQT----PKETAGKTLGTLQ 152
Cdd:PRK11102 45 FYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL---AAAAASVVINALMrdmfPKEEFSRMMSFVT 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 153 MGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNE-------QPLGEK---QNKRKTYSRKQVLSYIF 222
Cdd:PRK11102 122 LVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPEtlpkerrQPFHLRttiRNFASLFRHKRVLGYML 201
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
66-197 |
1.99e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 43.29 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 66 VTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAG 145
Cdd:cd17372 42 VVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLPAKSRG 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 494650715 146 KTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYtffitsFVIFASVLLVLFQV 197
Cdd:cd17372 122 TWMVLFSVFWTVGTIFEASLAWLVMPRLGWRW------LLAFSSVPSSLLLV 167
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
68-207 |
2.07e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.52 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 68 FLMAFVIS-PFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTG-FVPTSLAMISAQTPKETAG 145
Cdd:TIGR00711 46 YMLANAISiPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGpLIPLSFSTLLNIYPPEKRG 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494650715 146 KTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQN 207
Cdd:TIGR00711 126 RAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASEN 187
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
98-400 |
2.41e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.06 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 98 IAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQV------SGTLFGPMLGGLLAD 171
Cdd:cd06180 74 TVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVglgialSGLLVPAGLGGGLSW 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 172 SFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKqvlsyifhqpaLWAMMVLTMIVQTGNFSIQPLLALY 251
Cdd:cd06180 154 RAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRP-----------LWRLALAYGLFGFGYIITATFLPLI 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 252 VNELHGPvnlAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMG 331
Cdd:cd06180 223 ARETGAG---SLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFM 299
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 332 GTLPCITAAIRvRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGF-SISAAFYVTAFLFLIGAGLLW 400
Cdd:cd06180 300 AITALVMALAR-ELAPPAAPRALALMTASFGVGQILGPLLAGWLADATgGFAPALILAAAALVVAALLAL 368
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
35-400 |
3.00e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 42.56 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 35 TMIVPFLSLYIEtisphSGGYVqrwsGYVFGVTFLMAFVISPFWGRFGDKRGYKkILLITGTGIA-VSILLMGFVTSVYQ 113
Cdd:cd17384 17 TVVVPIIPDYLN-----ENVRV----GLLFASKALVQLITNPIVGPLTNRIGYS-LPMFVGFVIMfISTLLFAFGESYGV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 114 LFVLRLLMGLVTGFVPTS-LAMISAQTPKETA-GKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVL 191
Cdd:cd17384 87 LFLARALQGVGSACSSVAgMGMLASLYPDDKErGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 192 LVLFQVneQPLGEKQNKRKTYSRKQVLS--YIfhqpalwamMVLTMIVQTGNFSI---QPLLALYVNELHGPVNLAFfsG 266
Cdd:cd17384 167 LQLFIL--QPSVKSEESEEGTPWKTLLKdpYI---------LIAAGAICFSNSGIailEPCLPIWMMETMCPPKWQL--G 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 267 MAFSATGLGSLLLARKWGDFGDRFGHSRILIV--LLIASAVFFIPqaLASSLSILLVFRFL----FGMVMGGTLPCITAA 340
Cdd:cd17384 234 TAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLgmLLVGISLILIP--LAKNIYGLIIPHFGlglgIGMVDSSMMPLLAYL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494650715 341 IRVRAPgSIQGEVLGY-NVSFRfLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17384 312 VDLRHS-SVYGSVYAIaDVAFC-LAFALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLF 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-173 |
3.01e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 18 KNFVVIWITNFFISASMTMIVPFLSLYIETIsphsGGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTG 97
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGV----LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 98 IAVSILLMGFV---TSVYQLFVLRLLMGLVTGF-VPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSF 173
Cdd:cd17321 244 TAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLfATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
6-194 |
3.12e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 6 KSKEGDVISVRKKNFVVIWITNFFISASMTMIVPFLSLYietisphsggYVQRWSGYVFGVTFLMAFVI-----SPFWGR 80
Cdd:cd17478 183 KSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFY----------LVQRGYSLVFAGLLLSLFLFagaigTLIGGP 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 81 FGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKET---AGKTLGtlqMGQVS 157
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVglaSGLMMG---LSFGL 329
|
170 180 190
....*....|....*....|....*....|....*..
gi 494650715 158 GTLFGPMLgGLLADSFGFTYTFFITSFVIFASVLLVL 194
Cdd:cd17478 330 GGIGAPVL-GALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
283-400 |
3.25e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.65 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 283 WGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRF 362
Cdd:cd17312 58 SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHN 137
|
90 100 110
....*....|....*....|....*....|....*...
gi 494650715 363 LGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17312 138 FGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF 175
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
78-400 |
3.40e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 42.60 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 78 WGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLvtgFVPTSLAMISAQTPKETAGKTLGTLQMGQVS 157
Cdd:cd17485 59 LPRLGRRRSWLLPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNL---FSATQDIATDGLAVELLTPEERGLGNAAQVV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 158 GTLFGPMLGG----LLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSYIFHQPALWAMMVL 233
Cdd:cd17485 136 GYKLGSLLGGggllWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLF 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 234 TMIVQTGNFSIQPLLALYVNELH------GPVNLAFFSGMAFSATGLGSLLLARkwgdfgdRFGHSRILIVLLIASAVFF 307
Cdd:cd17485 216 LLLYKLGEQGALAMLPPFLVDRGfslsqiGLLSGVGGSLVSIAGSLLGGYLLKR-------RGRRRLLLLGGLLRLLLLG 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 308 IPQALASSLS---------ILLVFRFLFGMVMGGTLPCITAAIRVRAPG---SIQgevlgynVSFRFLGNVLGPLLGGAV 375
Cdd:cd17485 289 LYTLLALGGSglnwvlllaSLALLHLVGGMITTALFTLMMDCSQQAQAGtdyTLL-------ATVEVLGKLLFGSLAGFL 361
|
330 340
....*....|....*....|....*
gi 494650715 376 SSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17485 362 ADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
71-398 |
3.46e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 42.63 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 71 AFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGT 150
Cdd:cd17393 47 ALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 151 LQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPLGEKQNKRKTYSRKQVLSYIFHQPALWAM 230
Cdd:cd17393 127 LHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 231 MVLTMIVQTGnfSIQPLLALY-VNELHGPVNLAFFSGMAFSATglgsLLLARKWGDFG-DRFGHSRILIVLLIASAVFFI 308
Cdd:cd17393 207 LALAAALAEG--AAADWSALYlRDVLGASAALAALGYAVFSLA----MTVGRLFGDRLvDRFGDVAVLRAGALLAALGLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 309 PQALASSLSILLVFRFLFGMVMGGTLPCITAAIRvRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVT 388
Cdd:cd17393 281 LALLAPSVWVALAGFALMGLGLSVVVPLAFSAAG-ALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVV 359
|
330
....*....|
gi 494650715 389 AFLFLIGAGL 398
Cdd:cd17393 360 ALLALLVALL 369
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
28-195 |
4.04e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.21 E-value: 4.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 28 FFISASMTMIVPFLSLYIETISPH------SGGYVqrwsGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGT-GIAV 100
Cdd:cd17385 204 LLLCLSIVSGSVSLGFLDPTLSPHlrqfklSPGQV----GLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVIGSiITGV 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 101 SILLMG------FVTSVYQLFVLRLLMGLVTG--FVPTSLAMIsaQTPKETAG-KTLGTLqmGQVS---------GTLFG 162
Cdd:cd17385 280 GFLLLGpapllpIKSELWMVIIGLVLLGLSLGaaLVPTFPELL--NCAREYGFpDNLSTY--GLVSglfnaafslGAFIG 355
|
170 180 190
....*....|....*....|....*....|....
gi 494650715 163 PMLGGLLADSFGFTY-TFFITSFVIFASVLLVLF 195
Cdd:cd17385 356 PTLGGFLLERLGFEWaATIQAGLAFVVGILMSIY 389
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
132-400 |
5.02e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.10 E-value: 5.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 132 LAMISAQTPKETAGKTLG------TLQMGqvsgtLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQVNEQPlGEK 205
Cdd:cd17337 111 LVWITYRTPAERLGSAVGwfwfafTGGLP-----VLGSYLASFTIPVIGEIGTLWLSLVFVALGGLIALFLVRDRT-GEQ 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 206 QNKRKTYSRKQVL----SYIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGpvnlafFS--------GMAFSATG 273
Cdd:cd17337 185 PLANPSEEPLKELlsgiTILFRNPKIAIGGIVRIINTLSQFGFPVFMPLYFTDTGG------FStsqwlqiwGIIFLVNI 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 274 LGSLLlarkWGDFGDRFGHSRIL-----IVLLIAS-AVFFIPQALASSLSILLVFRFLFGMVMGGTLPcITAAIRVRAPG 347
Cdd:cd17337 259 FFNLI----FGILGDKIGWRRTVrwfggVGCAISTlLFYYVPQLFGHNYWAALIAAILFGIGLAGFVP-LSALMPSLAPE 333
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 494650715 348 SIQGEVLGYNVSfRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGAGLLW 400
Cdd:cd17337 334 HKGAAMSILNLG-AGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTL 385
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
262-336 |
5.62e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 5.62e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494650715 262 AFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPC 336
Cdd:TIGR00898 126 AWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQ 200
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
63-402 |
5.70e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 5.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 63 VFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFV-LRLLMGLVTGFVPTSLAMISAQTPK 141
Cdd:cd17352 43 IGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVGQYFE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 142 ETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLfqvneqplgekqnkrktysrkqvLSYI 221
Cdd:cd17352 123 KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGL-----------------------LLRL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 222 FHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLArkwGDFGDRFGHSR--ILIVL 299
Cdd:cd17352 180 LKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILL---GLLADKPRIGRlyLYIFT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 300 LIASAVFFIPQALASSLSILLVFRFLFGMVMGG----TLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGnvlGPLLGGAV 375
Cdd:cd17352 257 LLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSysslTPVILADLVGLEKLSNAYGLVLLFQGLAALVG---PPIAGLLR 333
|
330 340
....*....|....*....|....*..
gi 494650715 376 SSGFSISAAFYVTAFLFLIGAGLLWMA 402
Cdd:cd17352 334 DYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
54-195 |
1.09e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 54 GYVQRWSGYVFGvTFLMAFVISP-FWGRFGDKRGYKKILLITGTGIAVSILLMGFV--TSVYQLFVLRLLMGLVTGFVPT 130
Cdd:cd17380 30 GWSKTDQGLVLS-SFFWGYALTQvLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 131 SLAMISAQT-PKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:cd17380 109 SMTSLFSRWvPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLI 174
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
227-400 |
1.11e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.06 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 227 LWAMMVLTMIVQTGNFSIQPLLALYVN-ELHGPVNLAFFSGMAFSATGLGSLLLArkwGDFGDRFGHSRILIVLLIASAV 305
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHqQLGLSASIVGLVLALSAVAGIVASLIG---GRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 306 FFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVsSGFSISAAF 385
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLF 156
|
170
....*....|....*
gi 494650715 386 YVTAFLFLIGAGLLW 400
Cdd:cd17329 157 LAAAVLFLLAALVLL 171
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
66-188 |
1.24e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 40.57 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 66 VTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAG 145
Cdd:cd17441 42 VVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRA 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 494650715 146 KTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITS--FVIFA 188
Cdd:cd17441 122 KCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAlpLLIFA 166
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
65-337 |
1.91e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.98 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 65 GVTFLMAFVISPFWGRFGDKRGYKKILLITgtgiAVSILLMGFVTSVY-QLFVLRLLMGLVTGFVPTSLAMISAQTPKET 143
Cdd:TIGR00886 48 LAGAVLRIILGFLVDIFGPRYTTALSLLLL----AIPCLWAGLAVQSYsVLLLIRLFIGIAGGSFASCMPWISFFFPKKI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 144 AGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTF-----------FITSFVIFASVLLVLFQVNEQPLGEKQNKRktY 212
Cdd:TIGR00886 124 QGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQpahlawgwafvIVPAGILLLPALLIFFVGADTPPGKPATGK--L 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 213 SRKQVLSyIFHQPALWAMMVLTMIVQTGNFSIQPLLALYVNELHG--PVNLAFFsgmAFSATGLGSllLARKWGDF-GDR 289
Cdd:TIGR00886 202 SFKEALK-VFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGlsKVQAGAY---ASLGGFLGS--LARPAGGAiSDR 275
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 290 FGHSRIL--IVLLIASAVFFI------PQALASSLSILLVFRFLFGMVMGGTLPCI 337
Cdd:TIGR00886 276 LGGARKLlmNFLGVAMGAFLVvlglvsDGSLAAFIVLFVALFFFAGAGNGSTFALV 331
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
263-332 |
1.97e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 40.10 E-value: 1.97e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 263 FFSGMAFSATGLGSLllarkwgdfGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGG 332
Cdd:cd17447 44 FFAGVTMGAVAFGYL---------SDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTG 104
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
61-195 |
1.99e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.11 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGVTFLMAFVISPFWGRFGDKRGYKKILlitGTGIAVSILLMGFVTSVYQ-LFVLRLLMGLVTGF-----VPTSLAM 134
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSI---GIGMFLSSVISIVIPWAAGgGIALVVFCRVIQGLaqgsvSPATHKI 155
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494650715 135 ISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLF 195
Cdd:TIGR00894 156 IVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWF 216
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
60-178 |
2.44e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.35 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 60 SGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQ 138
Cdd:TIGR01299 204 KGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFgIGGAIPIVFSYFAEF 283
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 494650715 139 TPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYT 178
Cdd:TIGR01299 284 LAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQ 323
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
266-402 |
2.78e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 266 GMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAV--FFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRV 343
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALltLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 494650715 344 RAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLfligaGLLWMA 402
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGL-----GLLWCL 192
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
58-396 |
3.06e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.53 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 58 RWSGYVFGVTFLMAFVISPF--------WGRFGDKRGYkkiLLITGTGIAVSILLMGFVTSV-YQLFVLRLLMGLVTGFV 128
Cdd:cd17313 34 ALIGFVWTLGPILGLFVQPLvgslsdrcNSRIGRRRPF---ILVGAPLAALGLILIPNAADIgLALGDGPRTWALVLFVL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 129 PTSL-------------AMISAQTPKETAGKTLGTLQM----GQVSGTLFGPMLGGLLADSFGFT----YTFFITSFVIF 187
Cdd:cd17313 111 GIVLldfamnvcqgpvrALLPDLVPPEQRSKANGIINFmgglGGVLGYLLGAILWDHNWFGFALGgnlkVPFYIGAIILL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 188 ASVLLVLFQVNEQPLG-----EKQNKRKTYSRKQVLSYIFHQP-ALWAMMVLTMIVQTGNFSIQPLLALYVNE--LHGP- 258
Cdd:cd17313 191 VCVLVTLFFVKEPPLSpeageHSENPSLGEVLKSLLKLLKIMPrSLLRLLLVIFFWWIAFFPFELFFTDYMGEevYHGTs 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 259 ---------VNLAFFSGMAFSATGLGSLLLARKwgdFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMV 329
Cdd:cd17313 271 aasshygagVRMGAWGLLIFSLAFLIFSLPIGK---LGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494650715 330 MGG--TLPCITAAIRVRAPGSIQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLIGA 396
Cdd:cd17313 348 WATinINPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSL 416
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
61-197 |
3.17e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 61 GYVFGvTFLMAFVISPF-WGRFGDKRGYKKILlitGTGIAVSILLMGFV-----TSVYQLFVLRLLMGLVTGFV-PTSLA 133
Cdd:cd17318 59 GIILS-SFFYGYILTQIpGGYLAEKYGAKRVL---GYSILITALLTLLTplaarGGYGALIVLRILQGLAQGVTfPAMHA 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494650715 134 MISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFITSFVIFASVLLVLFQV 197
Cdd:cd17318 135 LWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
67-203 |
3.26e-03 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 39.60 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 67 TFLMAFVISPF-WGRFGDKRGYKKILLITGTGIAVSILLMGFVT------SVYQLFVLRLLMGLV--TGFvPTSLAMISA 137
Cdd:cd17342 71 IFLFSYAIGLFiSGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLqsTGW-PCVVAIMGN 149
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494650715 138 QTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADsFGFTYTFFITSFVIFASVLLVLFQVNEQPLG 203
Cdd:cd17342 150 WFGKSSRGFVLGLWSACASVGNIIGALLASSVLD-YGYEYAFLVTSSLLFAGAIVVFFGLLSSPPG 214
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
265-375 |
4.93e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.19 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 265 SGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVR 344
Cdd:TIGR01299 204 KGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEF 283
|
90 100 110
....*....|....*....|....*....|.
gi 494650715 345 APGSIQGEVLGYNVSFRFLGNVLGPLLGGAV 375
Cdd:TIGR01299 284 LAQEKRGEHLSWLCMFWMIGGIYAAAMAWAI 314
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
22-399 |
5.25e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.73 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 22 VIWITNFFISASMTMIVPFLSLYIETISPHSGGYvqrWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTGIAV- 100
Cdd:cd17326 3 VMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATAS---FFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 101 -----SILLMGFVTSVYQLFVLRLLMGLVTGFVPTSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLAdSFGF 175
Cdd:cd17326 80 gnilyALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT-PIGY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 176 T-YTFFI-------TSFVIFASVLLVLFQVneqplgekqnkrktysrkqVLSYIFHQPALWAMMVLTMIVQTGNFSIQPL 247
Cdd:cd17326 159 PgYVIGIklrfnmyTAPAWLMAILGIINII-------------------LILFFFKEVVCIFLFFVVLFIFANLETIGTP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 248 L--ALYVNELHGPVnlaFFSGMAFSATGLGSLLLA------RKWgDFGDRFghsrILIVLLIASAVFFIpqalasslsIL 319
Cdd:cd17326 220 LtmDMYGWTREEAV---LYNGIILAVSGVLSVLVFllfkflSLG-LIDERK----ILLGGLILFFLGFV---------VT 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 320 LVFRFLFGMVMGGTLPCITAAI-----RVRAPGSiQGEVLGYNVSFRFLGNVLGPLLGGAVSSGFSISAAFYVTAFLFLI 394
Cdd:cd17326 283 LPWGITGVILFGLGYPIGNVMLytlysKILGPKP-QGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLL 361
|
....*
gi 494650715 395 GAGLL 399
Cdd:cd17326 362 AIILL 366
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
15-195 |
6.20e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 15 VRKKNFVVIWITNFFISASMTMIVPFLSLYIETIsphsgGYVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLIT 94
Cdd:cd17335 195 LRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL-----GGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 95 GTGIAVSILLMGFVTSVYQLFVLRLLMGLVTGFV-PTSLAMISAQTPKETAGKTLGTLQMGQVS-GTLFGPMLGGLLADS 172
Cdd:cd17335 270 LLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVwAAAVSYASAAAPPGLRATAQGLLQGLYFGlGGGLGSLIGGYLYEA 349
|
170 180
....*....|....*....|...
gi 494650715 173 FGFTYTFFItsFVIFASVLLVLF 195
Cdd:cd17335 350 FGARTTFRF--FAIAALAGLLAF 370
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
55-195 |
6.21e-03 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 38.41 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 55 YVQRWSGYVFGVTFLMAFVISPFWGRFGDKRGYKKILLITGTG------IAVSILLMGFVTSVYQLFVLRLLMGLVTGFV 128
Cdd:cd17386 27 YAANFYLYMNLMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGlllsslILVLIVYFTTVPSVWWFYLSAIPLALFGGFT 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494650715 129 P---TSLAMISAQTPKETAGKTLGTLQMGQVSGTLFGPMLGGLLADSFGFTYTFFI-TSFVIFASVLLVLF 195
Cdd:cd17386 107 AflsASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSIsAALLLIALLYILFF 177
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
240-400 |
6.89e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 6.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 240 GNFSIQPLLALYVNELHGpvNLAFFSGMAFSATGLGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSIL 319
Cdd:cd17472 11 GMFLVLPVLSVYAKSLPG--ATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 320 LVFRFLFGM--VMGGTLPCITAAI----RVRAPGSIqGEVLGynVSFrFLGNVLGPLLGGAvssgFSISAAFYVTAFLFL 393
Cdd:cd17472 89 ILGRALQGSgaISSVVMALLADLTreenRTKAMALI-GASIG--IAF-AISMVLGPLLAAH----LGVSGLFLITAILSL 160
|
....*..
gi 494650715 394 IGAGLLW 400
Cdd:cd17472 161 VSLLILL 167
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
274-386 |
8.62e-03 |
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Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.37 E-value: 8.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 274 LGSLLLARKWGDFGDRFGHSRILIVLLIASAVFFIPQALASSLSILLVFRFLFGMVMGGTLPCITAAIRVRAPGSIQGEV 353
Cdd:cd17438 45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124
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90 100 110
....*....|....*....|....*....|....*..
gi 494650715 354 LGYNVSFRFLGNVLGPLLGGAV----SSGFSISAAFY 386
Cdd:cd17438 125 LSWLCMFWMIGGLYASAMAWSIiphyGWGFSMGTNYH 161
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| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
68-212 |
9.11e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 37.95 E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 68 FLMAFVISP-FWGRFGDKRGYKKILLITGTGIAVSILLMGFVTSVYQLFVLRLLMGL-VTGFVPTSLAMISAQTPKETAG 145
Cdd:PRK11043 50 FLAGFALGQlLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVgVCSAAVIWQALVIDRYPAQKAN 129
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494650715 146 KTLGTLqMGQV--SGTLfGPMLGGLLADSFGFtYTFFITSFVI-FASVLLVLFQVNEQPLGEKQNKRKTY 212
Cdd:PRK11043 130 RVFATI-MPLValSPAL-APLLGAWLLNHFGW-QAIFATLFAItLLLILPTLRLKPSKKARKQSQDALTF 196
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