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Conserved domains on  [gi|494652236|ref|WP_007410180|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Bacillus]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 1.61e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 137.22  E-value: 1.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   1 MKLDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKNGKYDQ 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 494652236  81 FKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEHF----INRTSPYAQTVTHVIF 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFllerLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 1.61e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 137.22  E-value: 1.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   1 MKLDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKNGKYDQ 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 494652236  81 FKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEHF----INRTSPYAQTVTHVIF 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFllerLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-109 4.79e-37

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 122.24  E-value: 4.79e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236     3 LDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKN-GKYDQF 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENpDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 494652236    82 KTYIQSIPNIEFCFRVAGAACYMLKMNA 109
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-143 3.59e-17

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 73.26  E-value: 3.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   3 LDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKNGK---YD 79
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGApdvFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494652236  80 QFKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEHFINRT----SPYAQTVTHVIFSEIDTKNVL 143
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETllrlPGVNDTRTYVVMEEVKQTNRL 159
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 4.08e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 59.31  E-value: 4.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 494652236    4 DNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 1.40e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 494652236   4 DNVDLSIIKELqRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRY 52
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 1.61e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 137.22  E-value: 1.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   1 MKLDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKNGKYDQ 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 494652236  81 FKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEHF----INRTSPYAQTVTHVIF 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFllerLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-109 4.79e-37

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 122.24  E-value: 4.79e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236     3 LDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKN-GKYDQF 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENpDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 494652236    82 KTYIQSIPNIEFCFRVAGAACYMLKMNA 109
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-143 3.59e-17

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 73.26  E-value: 3.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   3 LDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKNGK---YD 79
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGApdvFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494652236  80 QFKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEHFINRT----SPYAQTVTHVIFSEIDTKNVL 143
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETllrlPGVNDTRTYVVMEEVKQTNRL 159
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 4.08e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 59.31  E-value: 4.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 494652236    4 DNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 69-136 2.82e-11

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 55.61  E-value: 2.82e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494652236   69 VEATVKNGK-YDQFKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEHF----INRTSPYAQTVTHVIFSE 136
Cdd:pfam01037   1 VEVKLEPGHaLEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFlrekLRSLPGVARTETSIVLST 73
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
7-49 5.74e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 51.28  E-value: 5.74e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 494652236    7 DLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVI 49
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-121 2.17e-08

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 50.09  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   1 MKLDNVDLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKIGLPVSCIVEATVKNGK-YD 79
Cdd:PRK11179   5 YQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAKdYP 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 494652236  80 QFKTYIQSIPNIEFCFRVAGAACYMLKMNADSLETIEH-FINR 121
Cdd:PRK11179  85 SALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHvLINK 127
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-61 5.56e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 5.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 494652236     8 LSIIKELQRdsrLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKI 61
Cdd:smart00347  16 LRILYEEGP---LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSV 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 1.40e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 494652236   4 DNVDLSIIKELqRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKRY 52
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 8-111 4.74e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 35.66  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494652236   8 LSIIKELQRDSRL--SMRELGRKIKLSAPSVTERVRQLESFGVIKRYT--------LDIDQKKIGLPVSCIVEATVKNGK 77
Cdd:COG1974   12 LDFIKEYIRERGYppSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPgksraielLPASPEVVGLPLLGRVAAGFPIPA 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 494652236  78 YDQFKTYIqSIPniEFCFRVAGaACYMLKMNADS 111
Cdd:COG1974   92 EENIEEYL-DLP--EELVKNPG-ATFALRVKGDS 121
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-51 7.76e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.56  E-value: 7.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 494652236   7 DLSIIKELQRDSRLSMRELGRKIKLSAPSVTERVRQLESFGVIKR 51
Cdd:COG1846   40 QFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVER 84
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-61 7.84e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 32.90  E-value: 7.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 494652236    8 LSIIKELQRdsrLSMRELGRKIKLSAPSVTERVRQLESFGVIKRYTLDIDQKKI 61
Cdd:pfam01047   9 LRILYEHGP---LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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