|
Name |
Accession |
Description |
Interval |
E-value |
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
16-427 |
3.48e-93 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 287.43 E-value: 3.48e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 16 APKRQIFGWAMYDIANQAYTTIVISFVYSAFFVAYIVPEESQWRDAYWSIAIIGSTLIAMVLSPMVGHWIDRGVSKKKLL 95
Cdd:COG2270 7 ASRREILAWALYDWANSAFSTVITTFVFPPYFTSVAALGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 96 AWSTLICASFTCLLYFIGPGDVWWGIAIILITNTAWMVGEAIMSAFLPELASRKNMGLISGLGWGLGYLGGFVSMVMVSV 175
Cdd:COG2270 87 AFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLINLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 176 IIIRAD--PIAERGLYIaqhQWAMIAISIYFVLVAIPTFMLVKDKPKGTNLVPREHWRESL----NLFRQQRLQPVLFRF 249
Cdd:COG2270 167 LFLKPEafGLPDAGEAV---RISFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRAGFrelrRTLRELRRYRDLLRF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 250 FWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAISGMYG 329
Cdd:COG2270 244 LLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 330 IHDIAawlnmsvrdVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLA-ATFGIVADLF-SRQ 407
Cdd:COG2270 324 LTTAL---------AFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGpLLFGLVTQLTgSQR 394
|
410 420
....*....|....*....|
gi 494662383 408 NALLMVIAFFIIGAVLLARV 427
Cdd:COG2270 395 LGILSLIVFFVIGLVLLLRV 414
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
24-425 |
4.86e-53 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 181.26 E-value: 4.86e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 24 WAMYDIANQAYTTIVISFVYSAFFVAYIVPEESQWR-DAYWSIAIIGSTLIAMVLSPMVGHWIDRGVSKKKLLAWSTLIC 102
Cdd:cd17482 1 WALYDWANSAFATTVTTAVFPVYFKAVAAQGASPVTsTALWGYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 103 ASFTCLLYFIGPGDVWWGIAIILITNTAWMVGEAIMSAFLPELASRKNMGLISGLGWGLGYLGGFVSMVMVSVIIIRADp 182
Cdd:cd17482 81 VVSTALLFFVTPGQWLLALLLFILANIGFSGANVFYDAFLPDVASPERMDRVSSLGYALGYIGGGLLFAVNLVLILGPD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 183 iAERGLYIAQHQWAMIAISIYFVLVAIPTfmlvkdkpkgtnlvprehwreslnlfrqqrlqPVLFRFFWAFLFYMAGVQT 262
Cdd:cd17482 160 -AFGLDTAEAVRLSFLSVALWWALFSIPL--------------------------------KQLLLFLIAYFFYIDGVQT 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 263 VIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAIsgmygihdIAAWLnMSVR 342
Cdd:cd17482 207 IIRMATIYGAEEGKLGSSALILALLLTQFVAFPGALLFGWLAERFGAKRAILVSLVIYILIC--------IYAYF-MLTA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 343 DVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLA-ATFGIVADLF-SRQNALLMVIAFFIIG 420
Cdd:cd17482 278 WDFWILAALIGLVQGGIQALSRSLFGRLIPKGKSAEFFGFYNISGKFAAIIGpLLFGLITQLTgSSRYGILSLIVLFVIG 357
|
....*
gi 494662383 421 AVLLA 425
Cdd:cd17482 358 GILLA 362
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-425 |
1.26e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 81.49 E-value: 1.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 13 KKNAPKRQIFGWAMYDIANQAYTTIVISFVysAFFVAYI--VPEesqwrdAYWSIAIIGSTLIAMVLSPMVGHWIDRGVS 90
Cdd:COG2211 4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYL--LYFYTDVlgLSA------ALVGLILLVARLWDAITDPLIGALSDRTRT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 91 K----KKLLAWSTLICASFTCLLYFIGPGDVWWGIAIILITNTAWMVGEAIM----SAFLPELA-SRKNMGLISGLGWGL 161
Cdd:COG2211 76 RwgrrRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVnipySALGAELTpDYEERTRLSSWRFAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 162 GYLGGFVSMVMVSVIIIRADPIAERGLyiaqhQWAMIAISIYFVLVAIPTFMLVKDKPKGTNlvPREHWRESLNLFRQQR 241
Cdd:COG2211 156 AGLGGLLASVLPPPLVAAFGGDAALGY-----RLTALIFAVLGLLAFLLTFFGTKERPVPEE--EKVSLKESLKALLKNR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 242 lqpVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWI 321
Cdd:COG2211 229 ---PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 322 IAISGMYGIHDIAAWLnmsvrdvFLIVALLAGTGIGSIQASSRSLVGLLAAPE-------RDGSAFGLWGVFNRMAMLLA 394
Cdd:COG2211 306 LGLLLLFFLGPGNLWL-------LLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALA 378
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 494662383 395 AT--------FGIVADLFSRQNALL-MVIAFFIIGAVLLA 425
Cdd:COG2211 379 GAlaglllalFGYVAGAAQSPSALTgIRLLFFLLPAVLLL 418
|
|
| MFS_Atg22_like |
cd17483 |
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ... |
64-427 |
5.97e-15 |
|
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341036 Cd Length: 467 Bit Score: 76.54 E-value: 5.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 64 SIAIIGSTLIAMVLSPMVghwiDRGVSKKKLLAWSTLICASFTCLLYFIGPGDVWWGIAIILI-TNTAWMVGEAIMSAFL 142
Cdd:cd17483 74 SISVLLQAVLFISLGSLA----DYGNYRKRLLLTFTIIGSISSILFLFVPSPSLWWLAALLYIvSNICYGASLVFYNSFL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 143 PEL---------ASRKNMGLISGLGWGLGYLGGFVSMVMVS------------VIIIRADPIAERGLYIAQHQWAMIAIS 201
Cdd:cd17483 150 PILarnhpdvraARDKGSSLSAEATEEEISLEEKVSSRISSlgfasgyvggiiVQIISIIILFVLGNSIVSLRIAIAVVG 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 202 IYFVLVAIPTFMLVKDKP----KGTNLVPREHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGL 277
Cdd:cd17483 230 VWWLIFSVPTFLWLKPRPgpplPGGSHPIFYSWKSLFRTLKHARKLPETFIFLLAWFFLSDGINTISSTAVLFAKSQLHM 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 278 TQTDLVAVFLATQFSALFGAIGFG-VVERF-VGARKVL-FAVIGLWIIAISGMYGIHDIAAWLNmSVRDVFlIVALLAGT 354
Cdd:cd17483 310 STLQLILIGLLTPITAILGAFFFPrIQRRFnLSTKTMLmLIVVLTALIPLYGLLGFFTGKFGLK-HPWEMY-VLAVWFGF 387
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494662383 355 GIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAATF-GIVADLFSR-QNALLMVIAFFIIGAVLLARV 427
Cdd:cd17483 388 FLGGLQSYSRSLFSELIPPGHEAEFFSLFSITDKGSSWIGPLVvGAIIDATGNiRYGFIFLFALFVLPLPLLWFV 462
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
16-427 |
3.52e-13 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 71.14 E-value: 3.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 16 APKRQIFGWAMYDIANQAYTTIVISFVYSAFF--VAYI---------VPEESQWRD----------AYWSIAIIG---ST 71
Cdd:pfam11700 1 TTKKELWGWYLYCFAAEPFAVMAMGSFVPLTLqqLAREngvllsdhsAPCSADGDQcvvyfgggeiDTTSFVLYTfsiSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 72 LIAMVLSPMVGHWIDRGVSKKKLLAWSTLICASFTCLLYFIGPGDVWWGIAIILITNTAWMVGEAIMSAFLPELAsRKNM 151
Cdd:pfam11700 81 LLQAVVFISLSGIADYGNYRKNLLIAFALIGSASTMLFLGVTPKKYLLGAILYIVGNTCFGASFVFLNSFLPLLA-RNDP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 152 GLISGLGWGLGYLGGFVSMVMVSVIIIRADPIAERGLYI-----------------------AQHQWAM-IAI---SIYF 204
Cdd:pfam11700 160 ELRAAAEALQDGESAITAEEYDSLELQLRTRISSRGFGIgyiggilvqiisiiivyalgstaSNNTWALrLAItfaGCWW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 205 VLVAIPTFMLVKDKP-----KGTNLVpREHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQ 279
Cdd:pfam11700 240 IIFTIPWALWLRPRPgpplpSGLNYL-IYGWKQLGRTLKQARKLKDALLFLVAWFLLSDGIATVSSTAVLFAKTELGMST 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 280 TDLVAVFLATQFSALFGAIGFGVVERFVGAR--KVLFAVIGLWIIAIS-GMYGIHdiaaWLNMSVRDV--FLIVALLAGT 354
Cdd:pfam11700 319 SQLTLLNIVAMIAAVLGAFLWPFVSRRFNLKtkQTLIACIVLFELIPLyGLLGII----LGKIGLKNPweFWVLQAFYGL 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494662383 355 GIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLA-ATFGIVADLF-SRQNALLMVIAFFIIGAVLLARV 427
Cdd:pfam11700 395 VLGGLRSYSRSLYSELIPRGKEAQFFSLYAITDKGSSWIGpLIVGAIQDRTgNIRSPFVFLAILLVVPLPLLLLV 469
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
64-426 |
7.21e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.48 E-value: 7.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 64 SIAIIGSTLIAMVLSPMVGHWIDRgVSKKKLLAWSTL---ICASFTCLLYFIGPGDVWWGIAIILITNTAWMVGEAIMSA 140
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADR-FDRRRLLILADLlraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 141 FLPELASRKNMGLISGLGWGLGYLGGFVSMVMVSVIIIradpiaerglyIAQHQWAMIAISIYFVLVAIPTFMLVKDKPK 220
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA-----------LLGPGGAFAINALSFLLSALLLLFIRRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 221 GTNLVPREHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGF 300
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 301 GVVERFVGARKVLFAVIGLWIIAISGMYGIHDIAawlnmsvrdVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAF 380
Cdd:cd06173 265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLW---------LLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVF 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 494662383 381 GLWGVFNRMAMLLAATF-GIVADLFSRQNALLMVIAFFIIGAVLLAR 426
Cdd:cd06173 336 SVYNALNSGAMPLGALLaGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-426 |
7.75e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.36 E-value: 7.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 64 SIAIIGSTLIAMVLSPMVGHWIDRgVSKKKLLAWSTLICASFTcLLYFIGPGDVWWGIAIILI---TNTAWMVGEAIMSA 140
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVST-LLFAFATSYWQLLLARFLQglaSAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 141 FLPELASRKNMGLISGLGWGLGYLGGFVSMVMVSVIIIRadpiaerglyiaqhqWAMIAISIYFVLVAIPTFMLVKDKPK 220
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYR---------------APFLVCAALALLALVLALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 221 GTNLVPREHWRESLNLFRQqRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGF 300
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLL-LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 301 GVVERFVGARKVLfaVIGLWIIAISgmygihdIAAWLNMSVRDVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAF 380
Cdd:cd17325 256 GKLSDRIGRKPLI--LIGLLLSAVA-------LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 494662383 381 GLWGVFNRMAMLLAATF-GIVADLFSRQNALLMVIAFFIIGAVLLAR 426
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLgGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
57-424 |
1.61e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.36 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 57 QWRDAYWSIAIIGSTLIAMVLSPMVGHWIDRgVSKKKLLAWSTLICASFTCLLYFigPGDVWWGIAIILITNTAWMVGEA 136
Cdd:cd06174 27 GLSASQLGLLFALFSLGYALLQPLAGLLADR-FGRRPVLLLGLLLFALGALLFAF--APSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 137 IMSAFLPELASRKNMGLISGLGWGLGYLGGFVSMVMVSVIIIRadpiaerglYIAQHQWAMIAISIYFVLVAIPTFMLVK 216
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS---------LGFGWRAVFLIAAALALLAAILLLLVVP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 217 DKPKGTNLVP-REHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALF 295
Cdd:cd06174 175 DPPESARAKNeEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGAL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 296 GAIGFGVVERFVGARKVLFaVIGLWIIAISgmygihdIAAWLNMSVRDVFLIVALLAGTGIGSIQASSRSLVGLLAAPER 375
Cdd:cd06174 255 GSLLLGLLSDRLIGRKPLL-LIGLLLMALG-------LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 494662383 376 DGSAFGLWGVFNRMAMLLAATFG--IVADLFSRQNALLMVIAFFIIGAVLL 424
Cdd:cd06174 327 RGTAFGLLNTFGFLGGAIGPLLAgfLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
64-394 |
1.15e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 64 SIAIIGSTLIAMVLSPMVGHWIDRgVSKKKLLAWSTLICASFTCLLYFIGpgDVWWGIAIILITNTAWMVGEAIMSAFLP 143
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 144 ELASRKNMGLISGLGWGLGYLGGFVSMVMVSVIIIRADPiaerglyiaqhQWAMIAISIYFVLVAIPTFMLVKDKPKGTN 223
Cdd:COG2814 125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW-----------RWVFLVNAVLALLALLLLLRLLPESRPAAR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 224 LVPREHWRESLNlfrqqrlQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVV 303
Cdd:COG2814 194 ARLRGSLRELLR-------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 304 ERFVGARKVLFAVIGLWIIAISGMYGIHDIAAwlnmsvrdvFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLW 383
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWL---------LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLY 337
|
330
....*....|.
gi 494662383 384 GVFNRMAMLLA 394
Cdd:COG2814 338 NSAFFLGGPLA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
194-427 |
1.24e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.35 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 194 QWAMIAISIYFVLVAIPTFMLVKDKPKGTNLVPREHWRESLNLFRQqrlqPVLFRFFWAFLFYMAGVQTVIKFIGIYSTG 273
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRD----PRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 274 ELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAISGMygihdiaAWLNMSVRdVFLIVALLAG 353
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL-------ALALGSLW-LFLVLFLLLG 306
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494662383 354 TGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRM-AMLLAATFGIVADLF-SRQNALLMVIAFFIIGAVLLARV 427
Cdd:COG2223 307 LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLgGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-395 |
6.36e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 6.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 33 AYTTIVISFVYSAFFVAYIVPEESQWRDAYWSIAIIGSTLIAMVLSPMVGHWIDRgVSKKKLLAWSTLICASFTCLLYFI 112
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 113 GPgdVWWGIAIILITNTAWMVGEAIMSAFLPELASRKNMGLISGLGWGLGYLGGFVSMVMVSVIIIRADPiaerglyiaq 192
Cdd:pfam07690 83 SS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGW---------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 193 hQWAMIAISIYFVLVAIPTFmLVKDKPKGTNLVPREHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYST 272
Cdd:pfam07690 151 -RAAFLILAILSLLAAVLLL-LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 273 gELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAISGMYGIHDIAAWLnmsvrdVFLIVALLA 352
Cdd:pfam07690 229 -VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL------WLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 494662383 353 GTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAA 395
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
249-427 |
9.53e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 9.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 249 FFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAISgmy 328
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA--- 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 329 gihdIAAWLNMSVRDVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAAT-FGIVADLFSRQ 407
Cdd:COG2271 262 ----LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLlVGYLLDATGYQ 337
|
170 180
....*....|....*....|
gi 494662383 408 NALLMVIAFFIIGAVLLARV 427
Cdd:COG2271 338 AAFLLLAALALLAALLALLL 357
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
198-424 |
3.83e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.69 E-value: 3.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 198 IAISIYFVLVAIPTFMLVKDKPKGTnlvprEHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIkFIgIYSTGELGL 277
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPRP-----PKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFA-FL-ILRAQELGL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 278 TQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAISGMYGIHDIAAwlnmsvrdvFLIVALLAGTGIG 357
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWL---------LLLGFILWGLYMG 302
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494662383 358 SIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAAT-FGIVADLFSRQNALLMVIAFFIIGAVLL 424
Cdd:cd17370 303 AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLiAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
72-425 |
1.03e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.60 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 72 LIAMVLSPMVGHWIDRGVSK----KKLLAWSTLICASFTCLLYFIGPGDVWWGIAIILITNTAWMVGEAIM----SAFLP 143
Cdd:cd17332 46 IIDAINDPLMGYLIDRTRSRwgrfRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVnipyTALIP 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 144 ELASRKNmglisgLGWGLGYLGGFVSMVMVSVIIIRADPIAERGLYIAQHQWAMIAISIYFVLVAIPTFMLVkdkpKGTN 223
Cdd:cd17332 126 ELTDDPE------ERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICF----FGTR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 224 LVPREHWRES-----LNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQtDLVAVFLATQFSALFGAI 298
Cdd:cd17332 196 ERVVPPEEEKsklplLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRA-ELVLLLLLILSGALLALL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 299 GFGVVERFVGARKVLFAVIGLWIIAISGMYGIHDIAAWLnmsvrdvFLIVALLAGTGIGSIQASSRSLVGLLAAPE---- 374
Cdd:cd17332 275 PWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVL-------ILVLAVLAGIGYGGANLLPWAMLADVIDYGelkt 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494662383 375 ---RDGSAFGLWGVFNRMAM--------LLAATFGIVADLFSRQNALLMVI--AFFIIGAVLLA 425
Cdd:cd17332 348 gkrREGIFYSVMTFFRKLGLalagalvgLILSLAGYVANAAAQSASALNGIrlLIAVLPAVLLL 411
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
251-429 |
4.21e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.64 E-value: 4.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 251 WAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGV-VERFvGARKVLFAVIGLWIIAISGMYG 329
Cdd:COG2223 11 TLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFlVDRF-GPRRVLLIGLLLLGIGLLLLAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 330 IHDIAawlnmsvrdVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAATFG-IVADLFSRQN 408
Cdd:COG2223 90 AVSYW---------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLApLLIAAFGWRN 160
|
170 180
....*....|....*....|.
gi 494662383 409 ALLMVIAFFIIGAVLLARVTQ 429
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLR 181
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
199-427 |
6.96e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 199 AISIYFVLVAIPTFMLVKDKPKGTNLVPREHwreSLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLT 278
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPEPKEKAKSSSAT---KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 279 QTDLVAVFLATQFSALFGAIGFG-VVERFVGARKVLFAVIGLWIIAISGMYGIHDIAawlnmsvrdVFLIVALLAGTGIG 357
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLA---------LLLIAIVLFGLGLG 303
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494662383 358 SIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAA-TFGIVADLFSRQNALLMVIAFFIIGAVLLARV 427
Cdd:cd17474 304 LNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPlLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
238-427 |
9.64e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 9.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 238 RQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVI 317
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 318 GLWIIAISGMYGIHDIAawlnmsvrdVFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAATF 397
Cdd:COG2814 83 LLFALGSLLCALAPSLW---------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190
....*....|....*....|....*....|.
gi 494662383 398 -GIVADLFSRQNALLMVIAFFIIGAVLLARV 427
Cdd:COG2814 154 gGLLADLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
249-428 |
3.30e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 249 FFWAFLFYMAGVQTVIKFIGIYSTGELGLTQTDLVAVFLATQFSALFGAIGFGVVERFVGARKVLFAVIGLWIIAISGMY 328
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 329 GIHDIAAwlnmsvrdvFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGSAFGLWGVFNRMAMLLAATF-GIVADLFSRQ 407
Cdd:pfam07690 81 FASSLWL---------LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLgGLLASLFGWR 151
|
170 180
....*....|....*....|.
gi 494662383 408 NALLMVIAFFIIGAVLLARVT 428
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPR 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
71-423 |
4.53e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 71 TLIAMVLSPMVGHWIDRgVSKKKLLAWSTLICAsFTCLLYFIGPGdvWWGIAIILITNTAWM-----VGEAIMSAFLPEL 145
Cdd:cd17489 41 TLAALLARPFAGRLLDR-FGRKRLLLIGLLIFA-LATLLYLLATS--VALLLVLRLIHGIGWgafttAAATLVADIIPPS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 146 ASRKNMGLISGLGwglgylggFVSMVMVSVIiiradpiaerGLYIAQHQ--WAMIAISIYFVLVAIPTFMLVKDKPkgtn 223
Cdd:cd17489 117 RRGEGIGYYGLAT--------TLAMALGPAL----------GLFLYQHLgfAVLFIVAAVLALLALLLVFLVKDPP---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 224 lVPREHWRESLNLFRQQRLQPVLFRFFWAFLFYMAGVQTVIKFIGIYsTGELGLTQTDLVavFLATQFSALFGAIGFGVV 303
Cdd:cd17489 175 -PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY-AAERGISNAGLF--FTVYAIALLLSRPFSGKL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 304 ERFVGARKV-----LFAVIGLWIIAISGMygihdiaAWLnmsvrdvFLIVALLAGTGIGSIQASSRSLVGLLAAPERDGS 378
Cdd:cd17489 251 SDRKGPKTViipglLLLALGLLLLSFAGS-------PWM-------LLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 494662383 379 AFGLWGVFNRMAMLL-AATFGIVADLFSRQNALLMVIAFFIIGAVL 423
Cdd:cd17489 317 ANGTFFIFFDLGIGLgGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
33-146 |
2.38e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.98 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494662383 33 AYTTIVISFVYSAFFVAYIvpeesqWRDAYWSIAIIGSTLIAMVLSPMVGHWIDRGVSKKKLLAWSTLICASFTCLLYFI 112
Cdd:pfam13347 236 AALAMGVLNGLLLYYFRYV------LGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLL 309
|
90 100 110
....*....|....*....|....*....|....
gi 494662383 113 GPGDVWWGIAIILITNTAWMVGEAIMSAFLPELA 146
Cdd:pfam13347 310 GPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVV 343
|
|
| |
