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Conserved domains on  [gi|494760989|ref|WP_007496397|]
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MULTISPECIES: LysE family transporter [Bacillus]

Protein Classification

LysE family translocator( domain architecture ID 36)

LysE family translocator is involved in the efflux of one or more of a variety of biologically important solutes such as L-lysine, threonine, or homoserine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LysE super family cl00565
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
 1-191 1.69e-34

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


The actual alignment was detected with superfamily member PRK10323:

Pssm-ID: 444980  Cd Length: 195  Bit Score: 120.75  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   1 MIVSMLIYAFVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMI 80
Cdd:PRK10323   5 LLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  81 YLAVKIMRSKGGDDETLDRYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNMQYMLLTLILAIIGFLGTFSWSLFG 160
Cdd:PRK10323  85 WLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKIILYGITALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAG 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 494760989 161 SVFKRFLTLYQRPFQFVMGLLLMYSAISMIW 191
Cdd:PRK10323 165 HLFQRLFRQYGRQLNIVLALLLVYCAVRIFY 195
 
Name Accession Description Interval E-value
PRK10323 PRK10323
cysteine/O-acetylserine transporter;
1-191 1.69e-34

cysteine/O-acetylserine transporter;


Pssm-ID: 182377  Cd Length: 195  Bit Score: 120.75  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   1 MIVSMLIYAFVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMI 80
Cdd:PRK10323   5 LLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  81 YLAVKIMRSKGGDDETLDRYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNMQYMLLTLILAIIGFLGTFSWSLFG 160
Cdd:PRK10323  85 WLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKIILYGITALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAG 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 494760989 161 SVFKRFLTLYQRPFQFVMGLLLMYSAISMIW 191
Cdd:PRK10323 165 HLFQRLFRQYGRQLNIVLALLLVYCAVRIFY 195
RhtB COG1280
Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];
1-192 1.15e-31

Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];


Pssm-ID: 440891  Cd Length: 205  Bit Score: 113.78  E-value: 1.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   1 MIVSMLIYAFVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMI 80
Cdd:COG1280    5 LLLAFLLAALVLALTPGPDNLLVLSRGLRRGRRAGLAAALGIALGDLVHILLAALGLAALLAASPLLFTVLKLAGAAYLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  81 YLAVKIMRSKGGDDETLD-----RYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNMQYMLLTLILAIIGFLGTFS 155
Cdd:COG1280   85 YLGWKLLRSAGRPLAAEAaaaasARRLFRQGFLLNLLNPKAILFFLAFLPQFVDPGAPLLLQLLLLGATFLLVSLLWLLL 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 494760989 156 WSLFGSVFKRFLTL--YQRPFQFVMGLLLMYSAISMIWS 192
Cdd:COG1280  165 YALLASRLRRRLRSprALRWLNRVAGLLLIGFGLRLALS 203
LysE pfam01810
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
 10-181 1.10e-08

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


Pssm-ID: 280058  Cd Length: 193  Bit Score: 52.68  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   10 FVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMIYLAVKIMRS 89
Cdd:pfam01810   1 LSLALAPGPVNAFVLRQSISRGFKGGILVALGVVIGDAVLILLGLLGLATLLTASPILFSVLRLAGGAYLLWLGILMLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   90 KGG------DDETLDRYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNmqyMLLTLILAIIGFLGTFSWSL---FG 160
Cdd:pfam01810  81 AKSpkneslSSSEASLRKSFLRGLLVSLSNPKAILFWLSVFSAFLGKNQQYG---DAGRLIFAAGIVVASLIWFSllaFL 157

                         170       180
                  ....*....|....*....|.
gi 494760989  161 SVFKRFLTLYQRPFQFVMGLL 181
Cdd:pfam01810 158 ASRLARRLSTPKVRRIINVIA 178
 
Name Accession Description Interval E-value
PRK10323 PRK10323
cysteine/O-acetylserine transporter;
1-191 1.69e-34

cysteine/O-acetylserine transporter;


Pssm-ID: 182377  Cd Length: 195  Bit Score: 120.75  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   1 MIVSMLIYAFVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMI 80
Cdd:PRK10323   5 LLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  81 YLAVKIMRSKGGDDETLDRYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNMQYMLLTLILAIIGFLGTFSWSLFG 160
Cdd:PRK10323  85 WLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKIILYGITALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAG 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 494760989 161 SVFKRFLTLYQRPFQFVMGLLLMYSAISMIW 191
Cdd:PRK10323 165 HLFQRLFRQYGRQLNIVLALLLVYCAVRIFY 195
RhtB COG1280
Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];
1-192 1.15e-31

Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];


Pssm-ID: 440891  Cd Length: 205  Bit Score: 113.78  E-value: 1.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   1 MIVSMLIYAFVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMI 80
Cdd:COG1280    5 LLLAFLLAALVLALTPGPDNLLVLSRGLRRGRRAGLAAALGIALGDLVHILLAALGLAALLAASPLLFTVLKLAGAAYLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  81 YLAVKIMRSKGGDDETLD-----RYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNMQYMLLTLILAIIGFLGTFS 155
Cdd:COG1280   85 YLGWKLLRSAGRPLAAEAaaaasARRLFRQGFLLNLLNPKAILFFLAFLPQFVDPGAPLLLQLLLLGATFLLVSLLWLLL 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 494760989 156 WSLFGSVFKRFLTL--YQRPFQFVMGLLLMYSAISMIWS 192
Cdd:COG1280  165 YALLASRLRRRLRSprALRWLNRVAGLLLIGFGLRLALS 203
LysE pfam01810
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
 10-181 1.10e-08

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


Pssm-ID: 280058  Cd Length: 193  Bit Score: 52.68  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   10 FVTSFTPGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMIYLAVKIMRS 89
Cdd:pfam01810   1 LSLALAPGPVNAFVLRQSISRGFKGGILVALGVVIGDAVLILLGLLGLATLLTASPILFSVLRLAGGAYLLWLGILMLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989   90 KGG------DDETLDRYNHFIPGMLLQFINPKAILYGLTVISTFVLPYGQSNmqyMLLTLILAIIGFLGTFSWSL---FG 160
Cdd:pfam01810  81 AKSpkneslSSSEASLRKSFLRGLLVSLSNPKAILFWLSVFSAFLGKNQQYG---DAGRLIFAAGIVVASLIWFSllaFL 157

                         170       180
                  ....*....|....*....|.
gi 494760989  161 SVFKRFLTLYQRPFQFVMGLL 181
Cdd:pfam01810 158 ASRLARRLSTPKVRRIINVIA 178
PRK10958 PRK10958
leucine export protein LeuE; Provisional
 16-151 3.62e-08

leucine export protein LeuE; Provisional


Pssm-ID: 236807  Cd Length: 212  Bit Score: 51.42  E-value: 3.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  16 PGPNNIMAMVFTNKYGVKQTFRFCLGVGIGFLVILCLSGFFNMILYQVMPKIGWVMAFIGAGYMIYLAVKIMRS-----K 90
Cdd:PRK10958  24 PGPNSLYVLSTAARRGVKAGYRAACGVFIGDAVLMFLAAAGVASLLKATPLLFNVVKYLGAAYLLYLGVKMLRAalrrwR 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494760989  91 GGDDETLDRYNH-FIPGMLLQFINPKAILYGLTVISTFVLP-YGQSNMQYMLLTLILAIIGFL 151
Cdd:PRK10958 104 RRAASAAPPYGApFRRALILSLTNPKAILFFVSFFVQFVDPnYAHPALSFLILATILQLVSFC 166
rhtB PRK10520
homoserine/homoserine lactone efflux protein; Provisional
 41-152 8.16e-03

homoserine/homoserine lactone efflux protein; Provisional


Pssm-ID: 182514  Cd Length: 205  Bit Score: 35.85  E-value: 8.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494760989  41 GVGIGFLVILCLSGFFnmilyqvmpkigwVMAFIGAGYMIYLAVKIMRSKGGDD-----ETLDRYNHFIPGMLLQFINPK 115
Cdd:PRK10520  58 GVGLGALFSQSLLAFE-------------VLKWAGAAYLIWLGIQQWRAAGAIDlhtlaSTQSRRRLFKRAVFVNLTNPK 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 494760989 116 AILYGLTVISTFVLPYGQSNMQYMLL---TLILAIIGFLG 152
Cdd:PRK10520 125 SIVFLAALFPQFIMPQQPQLMQYLVLgvtTVVVDIIVMIG 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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