NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|494790601|ref|WP_007526009|]
View 

acyl carrier protein [Haemophilus sputorum]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0000035|GO:0006633|GO:0000036
PubMed:  20662770|18059524|30543875|30787330
SCOP:  4000857

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-77 1.75e-33

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 109.49  E-value: 1.75e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTKANA 77
Cdd:PRK00982  2 SEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-77 1.75e-33

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 109.49  E-value: 1.75e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTKANA 77
Cdd:PRK00982  2 SEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-72 2.51e-27

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 94.00  E-value: 2.51e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494790601   1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYV 72
Cdd:TIGR00517  2 QEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYI 73
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-77 2.11e-22

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 81.82  E-value: 2.11e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTKANA 77
Cdd:COG0236   4 EELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 5-67 8.40e-11

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 51.80  E-value: 8.40e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494790601   5 ERVKKIIVDQLGADAAAVKPEASFiEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQS 67
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 3-55 2.65e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 38.39  E-value: 2.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 494790601    3 IEERVKKIIVDQLG-ADAAAVKPEASFIeDLGADSLDTVELVMALEEEFDIEIP 55
Cdd:smart00823 13 LLDLVREQVAAVLGhAAAEAIDPDRPFR-DLGLDSLMAVELRNRLEAATGLRLP 65
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-77 1.75e-33

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 109.49  E-value: 1.75e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTKANA 77
Cdd:PRK00982  2 SEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-72 2.51e-27

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 94.00  E-value: 2.51e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494790601   1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYV 72
Cdd:TIGR00517  2 QEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYI 73
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 6-76 1.01e-25

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 92.07  E-value: 1.01e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494790601   6 RVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTKAN 76
Cdd:PTZ00171  74 RVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNN 144
acpP CHL00124
acyl carrier protein; Validated
 2-72 7.32e-23

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 82.76  E-value: 7.32e-23
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494790601  2 SIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYV 72
Cdd:CHL00124  5 DIFEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFI 75
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-77 2.11e-22

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 81.82  E-value: 2.11e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTKANA 77
Cdd:COG0236   4 EELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
PRK08172 PRK08172
acyl carrier protein;
1-65 4.91e-12

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 55.66  E-value: 4.91e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTV 65
Cdd:PRK08172  3 MDIEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTF 67
PRK12449 PRK12449
acyl carrier protein; Provisional
 3-74 7.46e-12

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 55.10  E-value: 7.46e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494790601  3 IEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTK 74
Cdd:PRK12449  6 IFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQ 77
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 5-67 8.40e-11

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 51.80  E-value: 8.40e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494790601   5 ERVKKIIVDQLGADAAAVKPEASFiEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQS 67
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK05350 PRK05350
acyl carrier protein; Provisional
 3-74 3.05e-06

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 40.74  E-value: 3.05e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494790601  3 IEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYVTK 74
Cdd:PRK05350  7 ILERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQKLTGKKIKPEEFKSVRTVQDVVDAVER 78
PRK06508 PRK06508
acyl carrier protein; Provisional
 5-58 4.77e-06

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 40.57  E-value: 4.77e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 494790601  5 ERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIPDEE 58
Cdd:PRK06508  6 DKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLPLEQ 59
PRK07081 PRK07081
acyl carrier protein; Provisional
 3-57 1.15e-05

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 39.17  E-value: 1.15e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 494790601  3 IEERVKKIIVDQ--LGADAAAVKPEASFIEdLGADSLDTVELVMALEEEFDIEIPDE 57
Cdd:PRK07081  1 MKNTIRTILKKVakLEVPIDSIADDADLYE-AGLSSLATVQLMLAIEDAFDIEIPDE 56
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 3-55 2.65e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 38.39  E-value: 2.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 494790601    3 IEERVKKIIVDQLG-ADAAAVKPEASFIeDLGADSLDTVELVMALEEEFDIEIP 55
Cdd:smart00823 13 LLDLVREQVAAVLGhAAAEAIDPDRPFR-DLGLDSLMAVELRNRLEAATGLRLP 65
PRK05828 PRK05828
acyl carrier protein; Validated
 31-72 1.79e-03

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 33.69  E-value: 1.79e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 494790601 31 DLGADSLDTVELVMALEEEFDIEIPDEEAEKITTVQSAIDYV 72
Cdd:PRK05828 34 ELKIDSLDMFSIIVSLESEFNIEFSDEKLMKLKNLADLILEV 75
PRK05087 PRK05087
D-alanine--poly(phosphoribitol) ligase subunit DltC;
1-55 2.01e-03

D-alanine--poly(phosphoribitol) ligase subunit DltC;


Pssm-ID: 179929  Cd Length: 78  Bit Score: 33.40  E-value: 2.01e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 494790601  1 MSIEERVKKIIVDQLGADAAAVKPEASFIEDLGADSLDTVELVMALEEEFDIEIP 55
Cdd:PRK05087  1 MDFKEQVLDILEELTGEDIVSENMDEDLFEEGILDSMGTVELLVELENRFDIEVP 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH