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Conserved domains on  [gi|494790642|ref|WP_007526050|]
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SLC13 family permease [Haemophilus sputorum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
72-621 2.87e-48

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 173.03  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  72 ALLYVVGEALSRTGIAYQISEHLMQIAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSM-----NIAPRR 146
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 147 LMMSLSMAGLISGMTTLIATVPNLVTHAELVKAGYAGFEFFDFAPIGFVVMVVAMLYMLIARNWLDNGEQASTSTSKEET 226
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 227 MSNLIAEYHLNGRAKMVILTelspfigktidqlklrsayhlniiaiqryknfrnitlaafgndqlrkkdillmdidvdea 306
Cdd:COG0471  161 REELAELGPLSRREKIALAI------------------------------------------------------------ 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 307 rftelcqefklqiielkgeyfsthaksvgmaefavkpetetigrtidslnfrsryglsvvgikrdaqilqqellketvks 386
Cdd:COG0471      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 387 gdvllvmgvwqkitvmaqnmkdlilldmpkesklaapaasqapyalfsVAVMVALMMSG---IVPNVIAGFIGCLLLGAF 463
Cdd:COG0471  181 ------------------------------------------------FALTVLLWITGslhGIPIAVVALLGAVLLLLT 212

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 464 RCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGAniSIYWVLMGLFAATAMVGLFISNGATAVL 543
Cdd:COG0471  213 GVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGL--SPLLLLLLLALLTLLLTEFASNTATAAL 290

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494790642 544 MAPFAIEVARQLGQSPSAFVMVVAIAASAAFMTPFS-PVNTMVVALGNYRFSDFLKVGLPMTIMTMLITTFLVPILFPL 621
Cdd:COG0471  291 LLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGtPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 336-404 2.20e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 56.08  E-value: 2.20e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494790642 336 MAEFAVKPETETIGRTIDSLNFRSRYGLSVVGIKRDAQILQQELLKETVKSGDVLLVMGVWQKITVMAQ 404
Cdd:COG0490   70 IEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEE 138
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 243-298 1.55e-04

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


:

Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 40.29  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 494790642  243 VILTELSPFIGKTIDQLKLRSAYHLNIIAIQRYKNFRNITlaafGNDQLRKKDILL 298
Cdd:pfam02080   4 VTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS----GDTVLEAGDRLL 55
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
72-621 2.87e-48

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 173.03  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  72 ALLYVVGEALSRTGIAYQISEHLMQIAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSM-----NIAPRR 146
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 147 LMMSLSMAGLISGMTTLIATVPNLVTHAELVKAGYAGFEFFDFAPIGFVVMVVAMLYMLIARNWLDNGEQASTSTSKEET 226
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 227 MSNLIAEYHLNGRAKMVILTelspfigktidqlklrsayhlniiaiqryknfrnitlaafgndqlrkkdillmdidvdea 306
Cdd:COG0471  161 REELAELGPLSRREKIALAI------------------------------------------------------------ 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 307 rftelcqefklqiielkgeyfsthaksvgmaefavkpetetigrtidslnfrsryglsvvgikrdaqilqqellketvks 386
Cdd:COG0471      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 387 gdvllvmgvwqkitvmaqnmkdlilldmpkesklaapaasqapyalfsVAVMVALMMSG---IVPNVIAGFIGCLLLGAF 463
Cdd:COG0471  181 ------------------------------------------------FALTVLLWITGslhGIPIAVVALLGAVLLLLT 212

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 464 RCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGAniSIYWVLMGLFAATAMVGLFISNGATAVL 543
Cdd:COG0471  213 GVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGL--SPLLLLLLLALLTLLLTEFASNTATAAL 290

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494790642 544 MAPFAIEVARQLGQSPSAFVMVVAIAASAAFMTPFS-PVNTMVVALGNYRFSDFLKVGLPMTIMTMLITTFLVPILFPL 621
Cdd:COG0471  291 LLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGtPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 20-211 7.19e-38

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 144.26  E-value: 7.19e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  20 LAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAG 99
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 100 ANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTHAELVKA 179
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                        170       180       190
                 ....*....|....*....|....*....|..
gi 494790642 180 GYAGFEFFDFAPIGFVVMVVAMLYMLIARNWL 211
Cdd:cd01115  161 GGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLA 192
CitMHS pfam03600
Citrate transporter;
27-211 2.08e-28

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 116.64  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   27 IFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAGANEAKII 106
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  107 MLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVThAELVKAGYAGFEF 186
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIII-ASALGLSFGDFGF 159

                         170       180
                  ....*....|....*....|....*
gi 494790642  187 FDFAPIGFVVMVVAMLYMLIARNWL 211
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKL 184
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 336-404 2.20e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 56.08  E-value: 2.20e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494790642 336 MAEFAVKPETETIGRTIDSLNFRSRYGLSVVGIKRDAQILQQELLKETVKSGDVLLVMGVWQKITVMAQ 404
Cdd:COG0490   70 IEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEE 138
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 21-204 6.98e-09

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 58.51  E-value: 6.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   21 AWLAVAIFLF-----LQNKLRLDVIALI-ILVGFALSGILTL---EEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQIS 91
Cdd:TIGR00785  10 AWLLLAIFVAaivgwILEPLPLPVTALLaIPIIAVLLGVLSAfkfKNALSGFADPTIWLFFGAFILATALVKTGLGKRIA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   92 EHLMQIAGANEAKIIMLLMFAITTIGSF-MSSTGIV-AIFIPVVVAICSSMNIAPRR--------LMMSLSMAGLISGMT 161
Cdd:TIGR00785  90 YKLVGKMGGTTLGLGYFLVFLETLLAPMwPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSG 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 494790642  162 TLIATVPNLVTHAELVKAGYAGFEFFDFAPIGFVVMVVAMLYM 204
Cdd:TIGR00785 170 FLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLV 212
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 336-394 7.68e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.83  E-value: 7.68e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  336 MAEFAVKPETETIGRTIDSLNFRSRYGLSVVGIKRDAQILQqeLLKETV-KSGDVLLVMG 394
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII--PSGDTVlEAGDRLLVIG 58
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 243-298 1.55e-04

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 40.29  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 494790642  243 VILTELSPFIGKTIDQLKLRSAYHLNIIAIQRYKNFRNITlaafGNDQLRKKDILL 298
Cdd:pfam02080   4 VTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS----GDTVLEAGDRLL 55
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 243-298 2.25e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 43.52  E-value: 2.25e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 494790642 243 VILTELSPFIGKTIDQLKLRSAYHLNIIAIQRyknfRNITLAAFGNDQLRKKDILL 298
Cdd:COG0569  245 VTVPEGSPLVGKTLKELDLRERYGVTVVAIKR----GGEVIIPSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
72-621 2.87e-48

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 173.03  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  72 ALLYVVGEALSRTGIAYQISEHLMQIAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSM-----NIAPRR 146
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 147 LMMSLSMAGLISGMTTLIATVPNLVTHAELVKAGYAGFEFFDFAPIGFVVMVVAMLYMLIARNWLDNGEQASTSTSKEET 226
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 227 MSNLIAEYHLNGRAKMVILTelspfigktidqlklrsayhlniiaiqryknfrnitlaafgndqlrkkdillmdidvdea 306
Cdd:COG0471  161 REELAELGPLSRREKIALAI------------------------------------------------------------ 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 307 rftelcqefklqiielkgeyfsthaksvgmaefavkpetetigrtidslnfrsryglsvvgikrdaqilqqellketvks 386
Cdd:COG0471      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 387 gdvllvmgvwqkitvmaqnmkdlilldmpkesklaapaasqapyalfsVAVMVALMMSG---IVPNVIAGFIGCLLLGAF 463
Cdd:COG0471  181 ------------------------------------------------FALTVLLWITGslhGIPIAVVALLGAVLLLLT 212

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 464 RCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGAniSIYWVLMGLFAATAMVGLFISNGATAVL 543
Cdd:COG0471  213 GVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGL--SPLLLLLLLALLTLLLTEFASNTATAAL 290

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494790642 544 MAPFAIEVARQLGQSPSAFVMVVAIAASAAFMTPFS-PVNTMVVALGNYRFSDFLKVGLPMTIMTMLITTFLVPILFPL 621
Cdd:COG0471  291 LLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGtPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 20-211 7.19e-38

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 144.26  E-value: 7.19e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  20 LAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAG 99
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 100 ANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTHAELVKA 179
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                        170       180       190
                 ....*....|....*....|....*....|..
gi 494790642 180 GYAGFEFFDFAPIGFVVMVVAMLYMLIARNWL 211
Cdd:cd01115  161 GGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLA 192
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 428-619 3.75e-37

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 142.34  E-value: 3.75e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 428 APYALFSVAVMVALMMS---GIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQ 504
Cdd:cd01115  189 FRLAVLIITIVLLAALAaitGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 505 EFVALTGGAniSIYWVLMGLFAATAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASAAFMTPFS-PVNT 583
Cdd:cd01115  269 ALISLLGGL--PPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGtPPNA 346

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 494790642 584 MVVALGNYRFSDFLKVGLPMTIMTMLITTFLVPILF 619
Cdd:cd01115  347 IVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
27-211 2.08e-28

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 116.64  E-value: 2.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   27 IFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAGANEAKII 106
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  107 MLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVThAELVKAGYAGFEF 186
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIII-ASALGLSFGDFGF 159

                         170       180
                  ....*....|....*....|....*
gi 494790642  187 FDFAPIGFVVMVVAMLYMLIARNWL 211
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKL 184
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 29-219 9.66e-20

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 91.54  E-value: 9.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  29 LFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAGaNEAKIIML 108
Cdd:cd00625    3 LIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASK-GSRRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 109 LMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNI-APRRLMMSLSMAGLISGMTTLIATVPNLVThAELVKAGYAGFE-F 186
Cdd:cd00625   82 LMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLsPPVPLLLALAFAANIGGAATPIGNPPNLII-ASLSGLGFLDFLaF 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 494790642 187 FDFAPIGFVVMVVAMLYMLIARNWLDNGEQAST 219
Cdd:cd00625  161 MAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLT 193
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 430-615 3.29e-18

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 86.92  E-value: 3.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 430 YALFSVAVMVALMMSGIVPNVIAG-FIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVA 508
Cdd:cd00625  211 LALLLLLLFVLLFFFLIPLGLIALlGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVA 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 509 LTGGaniSIYWVLMGLFAATAMVGLFISNGATAVLMAPFAIEVAR-----QLGQSPSAFVMVVAIAASAAFMTpfsPVNT 583
Cdd:cd00625  291 LVGL---PPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPpepawLALALGSTLGGNLTLIGSLANLI---PLGA 364

                        170       180       190
                 ....*....|....*....|....*....|..
gi 494790642 584 MVVALGNYRFSDFLKVGLPMTIMTMLITTFLV 615
Cdd:cd00625  365 AENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
439-619 1.27e-16

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 81.59  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  439 VALMMSGIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGANISIY 518
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  519 WVLMglfAATAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASAAF-MTPFS-PVNTMVVALGNYRFSDF 596
Cdd:pfam03600  81 VALM---LATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGtATPIGdPPNIIIASALGLSFGDF 157

                         170       180
                  ....*....|....*....|...
gi 494790642  597 LKVGLPMTIMTMLITTFLVPILF 619
Cdd:pfam03600 158 GFFMFPPVGVALLLVGLLPLLLI 180
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 440-620 2.91e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 81.14  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 440 ALMMSGIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGANisiyW 519
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSR----R 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 520 VLMGLFAATAMVGLFISNGATAVLMAPFAIEVARQLGQSP-SAFVMVVAIAASAA-FMTPFS-PVNTMVVALGNYRFSDF 596
Cdd:cd00625   78 LLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPpVPLLLALAFAANIGgAATPIGnPPNLIIASLSGLGFLDF 157

                        170       180
                 ....*....|....*....|....
gi 494790642 597 LKVGLPMTIMTMLITTFLVPILFP 620
Cdd:cd00625  158 LAFMAPPALGLLLLLLGLLYLLFR 181
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
431-620 3.40e-16

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 80.94  E-value: 3.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 431 ALFSVAVMVALMMSGI--VPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVA 508
Cdd:COG1055    5 ALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLAR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 509 LTGGANISIYWVLMGLFAATAMvglFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASAA-FMTPFS-PVNTMVV 586
Cdd:COG1055   85 RAKGSPRRLLWLLGLLTALLSA---FLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGnPTNIMIA 161

                        170       180       190
                 ....*....|....*....|....*....|....
gi 494790642 587 ALGNYRFSDFLKVGLPMTIMTMLITTFLVPILFP 620
Cdd:COG1055  162 SAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFR 195
CitMHS pfam03600
Citrate transporter;
413-567 2.08e-15

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 77.74  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  413 DMPKESKLAAPAASQAPYALFSVAVMVALMMSGIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIA 492
Cdd:pfam03600 190 EEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGA 269

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494790642  493 LQKTGGVAMMVQEFVALTGganisIYWVLMGLFAATAMVGLFISNGATAVLMAPFAIEVARQLGQ---SPSAFVMVVA 567
Cdd:pfam03600 270 LEKTGLADALADALGGLSG-----LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLgdpDPLAWALAVG 342
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
18-207 2.89e-15

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 77.89  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  18 WVLAWLAVAIFLFL---QNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHL 94
Cdd:COG0471  176 IALAIFALTVLLWItgsLHGIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADAL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  95 MQIAGANEAKIIMLLMFAITTIGS-FMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLiSGMTTLIATVPNLVTH 173
Cdd:COG0471  256 LPLLGGLSPLLLLLLLALLTLLLTeFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAAS-CAFLLPVGTPPNAIVY 334

                        170       180       190
                 ....*....|....*....|....*....|....
gi 494790642 174 aelvkaGYAGFEFFDFAPIGFVVMVVAMLYMLIA 207
Cdd:COG0471  335 ------GSGYYKFKDFLKVGLPLNLIGLVVLLLL 362
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 11-211 1.08e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 69.92  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  11 FMLQPLFWVLAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQI 90
Cdd:cd01115  187 FIFRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALI 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  91 SEHLMQIAGANEAKIIMLLMFAIT-TIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGlISGMTTLIATVPN 169
Cdd:cd01115  267 AEALISLLGGLPPFAILLLLCLLTlVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGA-SCAFMLPVGTPPN 345

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 494790642 170 LVTHaelvkaGYAGFEFFDFAPIGFVVMVVAMLYMLIARNWL 211
Cdd:cd01115  346 AIVL------GPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 435-619 1.25e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 69.92  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 435 VAVMVALMMSGIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGAN 514
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 515 ISIywvLMGLFAATAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASA-AFMTPF-SPVNTMVVAL---- 588
Cdd:cd01115   84 RRL---LLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIgGMLTLIgTPPNLVASGYlesl 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 494790642 589 --GNYRFSDFLKVGLPMTIMTMLITTFLVPILF 619
Cdd:cd01115  161 ggQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV 193
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 440-619 1.81e-12

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 69.59  E-value: 1.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 440 ALMMSGIVPNVIAGFIGCLLLGAFRCI----DMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGANI 515
Cdd:cd01116    6 ALIIFEKVHRTVAALAGALWLVILGLAtlspDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 516 SIYWVLMGLfaaTAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASAAFM-TPFS-PVNTMVVALGNYRF 593
Cdd:cd01116   86 RLLLLLGLL---TAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAaTLIGdPPNIMIGSAAGLTF 162

                        170       180
                 ....*....|....*....|....*.
gi 494790642 594 SDFLKVGLPMTIMTMLITTFLVPILF 619
Cdd:cd01116  163 NDFLLHMLPSVVLALVVTFILLYFLY 188
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 16-207 1.46e-10

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 63.42  E-value: 1.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  16 LFWVLAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLM 95
Cdd:cd00625  210 LLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLV 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  96 QIAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAIcssmnIAPRRLMMSLSMAGLISGMTTLIATVPNLVTHAE 175
Cdd:cd00625  290 ALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL-----APPEPAWLALALGSTLGGNLTLIGSLANLIPLGA 364

                        170       180       190
                 ....*....|....*....|....*....|..
gi 494790642 176 LVKAGYaGFEFFDFAPIGFVVMVVAMLYMLIA 207
Cdd:cd00625  365 AENAGV-GISFGEFLKVGLPLTLLSLVVSLLY 395
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
21-206 1.67e-10

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 63.22  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  21 AWLAVAIFL-------FLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEH 93
Cdd:COG1055    2 MILALAIFVltylliiLEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  94 LMQIAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTh 173
Cdd:COG1055   82 LARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMI- 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 494790642 174 aelvkAGYAGFEFFDF----APIGFVVMVVAMLYMLI 206
Cdd:COG1055  161 -----ASAGGLSFLDFlanlFPPSLVSLLVTLLVLYL 192
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 454-620 6.50e-10

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 61.52  E-value: 6.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 454 FIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGANIsiywVLMGLFAATAMVGL 533
Cdd:cd01117   18 LLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRR----LLFLLVLLSGILSA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 534 FISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASA-AFMTPF-SPVNTMVVALGNYRFSDFLKVGLPMTIMTMLIT 611
Cdd:cd01117   94 LLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIgSAATPIgNPQNLLIASESGISFPFFLAAMAPLALLGLLLL 173


                 ....*....
gi 494790642 612 TFLVPILFP 620
Cdd:cd01117  174 LILLLVLFP 182
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 336-404 2.20e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 56.08  E-value: 2.20e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494790642 336 MAEFAVKPETETIGRTIDSLNFRSRYGLSVVGIKRDAQILQQELLKETVKSGDVLLVMGVWQKITVMAQ 404
Cdd:COG0490   70 IEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEE 138
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 21-204 6.98e-09

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 58.51  E-value: 6.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   21 AWLAVAIFLF-----LQNKLRLDVIALI-ILVGFALSGILTL---EEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQIS 91
Cdd:TIGR00785  10 AWLLLAIFVAaivgwILEPLPLPVTALLaIPIIAVLLGVLSAfkfKNALSGFADPTIWLFFGAFILATALVKTGLGKRIA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   92 EHLMQIAGANEAKIIMLLMFAITTIGSF-MSSTGIV-AIFIPVVVAICSSMNIAPRR--------LMMSLSMAGLISGMT 161
Cdd:TIGR00785  90 YKLVGKMGGTTLGLGYFLVFLETLLAPMwPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSG 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 494790642  162 TLIATVPNLVTHAELVKAGYAGFEFFDFAPIGFVVMVVAMLYM 204
Cdd:TIGR00785 170 FLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLV 212
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
17-202 8.57e-09

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 57.83  E-value: 8.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  17 FWVLAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQ 96
Cdd:COG1055  222 LLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLAS 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  97 IAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPrrLMMSLSMAGLISGMTTLIATVPNLVThAEL 176
Cdd:COG1055  302 LTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIV-LGI 378

                        170       180
                 ....*....|....*....|....*.
gi 494790642 177 VKAGYAGFEFFDFAPIGFVVMVVAML 202
Cdd:COG1055  379 AEKKGIKISFGEFLKVGLPLTLLTLL 404
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 336-394 7.68e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.83  E-value: 7.68e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  336 MAEFAVKPETETIGRTIDSLNFRSRYGLSVVGIKRDAQILQqeLLKETV-KSGDVLLVMG 394
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII--PSGDTVlEAGDRLLVIG 58
CitMHS pfam03600
Citrate transporter;
18-144 1.57e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 50.39  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   18 WVLAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQI 97
Cdd:pfam03600 207 LLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 494790642   98 AGAneAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAP 144
Cdd:pfam03600 287 SGL--LVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
432-619 3.67e-06

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 49.74  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 432 LFSVAVMVALMMSGI--VPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVAL 509
Cdd:COG1055  223 LVLALLLVGFVLHSFlgLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 510 TGGaniSIYWVLMGLFAATAMVGLFISNGATAVLMAPfaieVARQLGQSPSAFVMVVAIAASAAF---MTPFSPVNTMVV 586
Cdd:COG1055  303 TGG---NLLLAALLILWLSAILSAVVDNVPLVAALLP----LIPDLGATGNPEPLWLALALGATLggnLTPIGSAANVIV 375

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 494790642 587 A------LGNYRFSDFLKVGLPMTIMTMLITTFLVPILF 619
Cdd:COG1055  376 LgiaekkGIKISFGEFLKVGLPLTLLTLLIALLYLLLLY 414
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 9-169 4.00e-06

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 49.65  E-value: 4.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642    9 PNFMLQPLFWVLAWLAV-AIFLFLQNKLRL---DVIALIILVGFALSGILTLEEVLAGFSNPNML-LLALLYVVGEALSR 83
Cdd:TIGR00785 240 EMGPMSFREKALLGIFLlALLLWIFGGSLGinaSVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLiLFGGLIGLAGGLKK 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   84 TGIAYQISEHLMQIAGANEAKIIMLLMFAITTI--GSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMT 161
Cdd:TIGR00785 320 SGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFL 399


                  ....*...
gi 494790642  162 TLIATVPN 169
Cdd:TIGR00785 400 TPYATPPN 407
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 444-612 4.10e-06

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 49.65  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  444 SGIVPNVIAGFIGCLLLGAFRCIDMKTAY-NAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGaNISIYWVLM 522
Cdd:TIGR00785 267 SLGINASVVALLAVVLMLFLGIVTWKDIQkNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDG-LSPTIAVLV 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  523 GLFAATAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAAS-AAFMTPFS-PVNTMVVALGNYRFSDFLKVG 600
Cdd:TIGR00785 346 LVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASlMGFLTPYAtPPNAIAYGSGYVKIKDMWRVG 425

                         170
                  ....*....|..
gi 494790642  601 LPMTIMTMLITT 612
Cdd:TIGR00785 426 AIIGIVGLIVLL 437
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 23-205 6.91e-06

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 48.79  E-value: 6.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  23 LAVAIFLFLQN--KLRLDVIALI-ILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAG 99
Cdd:cd01116  225 TLVIIGFVLHSplGVSLGWIALLgALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVIL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 100 ANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTHAELVKA 179
Cdd:cd01116  305 GRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQH 384

                        170       180       190
                 ....*....|....*....|....*....|
gi 494790642 180 GYaGFEFFDFAPIGFVVM----VVAMLYML 205
Cdd:cd01116  385 GY-KISFWEFLKVGFPIMlvslILATVYLL 413
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 40-205 6.32e-05

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 45.71  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  40 IALIILVGFALSGILTLEEVLA-GFSNPNMLLLALLYVVGeALSRTGIAYQISEHLMQIAGANEAKIIMLLMFAITTIGS 118
Cdd:cd01116   22 GALWLVILGLATLSPDLETIVSwVDWETLALLLGMMIIVS-ILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 119 FMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTHAElvkagyAGFEFFDF----APIGF 194
Cdd:cd01116  101 FLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGSA------AGLTFNDFllhmLPSVV 174

                        170
                 ....*....|.
gi 494790642 195 VVMVVAMLYML 205
Cdd:cd01116  175 LALVVTFILLY 185
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
35-400 6.56e-05

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 45.43  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  35 LRLDVIALIILVGFALSGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAGANEAKIIMLLMFAIT 114
Cdd:COG3273   29 LLIDLAYSAVLDESDALAEEVLELELRMDVLQLLARMSLLLAARALEEAELLAPVLGVVAAAVAISAAAGDIAKVVLEDI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 115 TIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTHAELVKAGYAGFEFFDFAPIGF 194
Cdd:COG3273  109 GLPEAMRAALPEAVETLVRATVAASSALAGRTLLLILLETETGVRVIAIRRGDDWLLNPGPTTILRADDLVLLRGPEGGI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 195 VVMVVAMLYMLIARN--------WLDNGEQAST--STSKEETMSNLIAEYHLNGRAKMVILTELspfigktIDQLKLRSA 264
Cdd:COG3273  189 LEVYLAATGDLYERPrppedsivEMKNLSELAVdlAYSSVLFDSEELAEEVRELEEEVDALKSR-------LEAWVLRAA 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 265 YHLNIIAIQRYKNFRNITLAAFGNDQLRKKDILLMDIDVDEArFTELCQEFKLQIIELKgeyfsthaksvgmaefaVKPE 344
Cdd:COG3273  262 RRVDDPVALRGLLHLASSTEVISDAALDIAEGVLRGLEDHPV-VAEAVRESDERIVRVT-----------------VPPG 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 494790642 345 TETIGRTIDSLNFRSRYGLSVVGIKRDAQILQQELLKETVKSGDVLLVMGVWQKIT 400
Cdd:COG3273  324 SPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLE 379
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 243-298 1.55e-04

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 40.29  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 494790642  243 VILTELSPFIGKTIDQLKLRSAYHLNIIAIQRYKNFRNITlaafGNDQLRKKDILL 298
Cdd:pfam02080   4 VTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS----GDTVLEAGDRLL 55
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 243-298 2.25e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 43.52  E-value: 2.25e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 494790642 243 VILTELSPFIGKTIDQLKLRSAYHLNIIAIQRyknfRNITLAAFGNDQLRKKDILL 298
Cdd:COG0569  245 VTVPEGSPLVGKTLKELDLRERYGVTVVAIKR----GGEVIIPSGDTVLEAGDELI 296
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 13-204 3.04e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 43.51  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   13 LQPLFWVLAWLAVAIFLFLQNK-LRLDVIALIILVGFA-LSGILT---LEEVLAGFSNPNMLLLALLYVVGEALSRTGIA 87
Cdd:pfam00939  26 LPSKAWHLFAIFIATIVGWILEpLPMAVIALFAISLSAiLIGTLLakaLSWALSGFSSTTTWLVFGAFFISAAFEKTGLG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   88 YQISEHLMQIAGANEAKIIMLLMFA------ITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRR-----LMMSLSMAGL 156
Cdd:pfam00939 106 RRIALVLVKKMGKRTLGLGYGLVFSdlllapATPSNTARAGGIVFPIIMSLPPAFGSDPEKGSERrigayLMWTVYQSTS 185

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 494790642  157 ISGMTTLIATVPNLVTHAELVKAGYAGFEFFDFAPIGFVVMVVAMLYM 204
Cdd:pfam00939 186 ITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPGVILLLLA 233
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 30-215 4.01e-04

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 43.04  E-value: 4.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  30 FLQNKLRLDVIALIILVGFAL---SGILTLEEVLAGFSNPNMLLLALLYVVGEALSRTGIAYQISEHLMQIAGaNEAKII 106
Cdd:cd01117    3 LGRVPGLRLDRWAIALLGAALmllFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAG-SPRRLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 107 MLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVThaelvkAGYAGFEF 186
Cdd:cd01117   82 FLLVLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLI------ASESGISF 155

                        170       180
                 ....*....|....*....|....*....
gi 494790642 187 FDFAPIGFVVMVVAMLYMLIARNWLDNGE 215
Cdd:cd01117  156 PFFLAAMAPLALLGLLLLLILLLVLFPGE 184
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 445-613 5.81e-04

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 42.62  E-value: 5.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 445 GIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGANISIYWVLMGL 524
Cdd:cd01116  238 GVSLGWIALLGALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWI 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 525 faaTAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAAS-AAFMTPF-SPVNtmVVALG-------NYRFSD 595
Cdd:cd01116  318 ---SALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGAClGGNGTLIgASAN--VVAAGiaeqhgyKISFWE 392

                        170
                 ....*....|....*...
gi 494790642 596 FLKVGLPMTIMTMLITTF 613
Cdd:cd01116  393 FLKVGFPIMLVSLILATV 410
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 243-274 6.18e-04

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 40.29  E-value: 6.18e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 494790642 243 VILTELSPFIGKTIDQLKLRSAYHLNIIAIQR 274
Cdd:COG0490   73 VKVPPGSPLVGKTLGELNLRQRTGVTVVAIRR 104
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 16-206 7.77e-04

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 42.25  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  16 LFWVLAWLAVAIFLFLQNKLRLDVIALIILVGFALSGILTLEEVLAGFS--NPNMLLLALLYVVGEALSRTGIAYQISEH 93
Cdd:cd01118    1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGivWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  94 LMQIAGANEAKIIMLLMFAITTIGSFMSSTGIVAIFIPVVVAICSSMNIAPRRLMMSLSMAGLISGMTTLIATVPNLVTh 173
Cdd:cd01118   81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVN- 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 494790642 174 aeLVKAGYAGFEFFDFAPIGFVVMVVAMLYMLI 206
Cdd:cd01118  160 --IVTAGYFGIGFTEYAALMFLPSIVSILATYV 190
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 458-620 9.40e-04

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 41.95  E-value: 9.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  458 LLLGAFRCIDMKTAYNAIHFPSIILIIGMMPFSIALQKTGGVAMMVQEFVALTGGANISIYWVLMglFAATAMVGLFISN 537
Cdd:TIGR00785  44 VLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLGYFLV--FLETLLAPMWPSN 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  538 GA-TAVLMAPFAIEVARQLGQSPS-------AFVMVVAIAASAA--FMTPF-SPVNTMVVALGN------YRFSDFLKVG 600
Cdd:TIGR00785 122 TArAGGILLPIIKSLLPLLGSKPEksprkigKYLMLGIAYSASIgsSGFLTgSAPNALAAGILSkilgiqISWGDWFLAG 201

                         170       180
                  ....*....|....*....|
gi 494790642  601 LPMTIMTMLITTFLVPILFP 620
Cdd:TIGR00785 202 LPLGIILLLLVPLLLYVLFP 221
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 40-210 1.79e-03

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 41.20  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642   40 IALIILVGFALSGILTLEEVLAGFSNPNMLL-LALLYVVGEALSRTGIAYQISEHLMQIAGA---NEAKIIMLLMFAITT 115
Cdd:pfam00939 296 VAIIGLALMLLLRILDWKDIVKNKGAWNTLIwLGGLIMLANGLERSGFIEWLGNTLSTSLSGfspAMAFIIILSLFYLSH 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642  116 IGsFMSSTGIVAIFIPVVVAICSSMNIAPRRL-MMSLSMAGLISGMTTLIATVPNLVthaelvkagYAGFEFF---DFAP 191
Cdd:pfam00939 376 YL-FASATAHTAAMLPIFAAVAQAIPGAPPLLaALLLGFAISLGGFLTPYGTGPGPI---------YFGSGYLkvkDWWR 445

                         170
                  ....*....|....*....
gi 494790642  192 IGFVVMVVAMLYMLIARNW 210
Cdd:pfam00939 446 IGAILTIIGLLILLLLGNW 464
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 325-375 4.77e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 39.28  E-value: 4.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 494790642 325 EYFSTHAKSVGMAEFAVKPETETIGRTIDSLNFRSRYGLSVVGIKRDAQIL 375
Cdd:COG0569  231 DVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVI 281
GntT COG2610
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and ...
 431-576 6.33e-03

H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and metabolism];


Pssm-ID: 442022 [Multi-domain]  Cd Length: 440  Bit Score: 39.33  E-value: 6.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494790642 431 ALFSVAVMVALMMSGIVPNVIAGFIGCLLLGAFRCIDMKTAYNAIH------FPSIILIIGM--MpFSIALQKTGGVAMM 502
Cdd:COG2610    7 LLLAIALLILLIIKFKLHPFLALLLAALLVGLLAGMPLAKIVTSIMtgfggtLGSIGLVIGLgaM-LGKLLEDSGAAERI 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494790642 503 VQEFVALTGGANisiywVLMGLFAATAMVGLFISNGATAVLMAPFAIEVARQLGQSPSAFVMVVAIAASAAFMT 576
Cdd:COG2610   86 ADTIIKKFGEKR-----APLALVLAGFILGIPVFFDVGFVILAPLAFSLARRAGISKLLIGLALAAGLSTTHML 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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