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Conserved domains on  [gi|494818081|ref|WP_007553489|]
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tRNA (cytidine(34)-2'-O)-methyltransferase [Bartonella sp. DB5-6]

Protein Classification

tRNA (cytidine(34)-2'-O)-methyltransferase( domain architecture ID 10000715)

tRNA (cytidine(34)-2'-O)-methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine to the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA)

EC:  2.1.1.207
Gene Ontology:  GO:0003723|GO:0008173|GO:1904047|GO:0141098|GO:0001510
SCOP:  4002340

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 3-155 1.27e-84

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 439989  Cd Length: 153  Bit Score: 244.94  E-value: 1.27e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   3 LHIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLS 82
Cdd:COG0219    2 LHIVLYEPEIPQNTGNIIRLCAATGARLHLIEPLGFSLDDKKLKRAGLDYWELVDLTVHDSWEAFLEALP--GGRLFLFT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494818081  83 TKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEA-VDCALKIPMQPHARSLNLAMSVAITTGEALRQIGYNEKR 155
Cdd:COG0219   80 TKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNAVAIVLYEALRQLGFPGLV 153
 
Name Accession Description Interval E-value
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 3-155 1.27e-84

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 244.94  E-value: 1.27e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   3 LHIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLS 82
Cdd:COG0219    2 LHIVLYEPEIPQNTGNIIRLCAATGARLHLIEPLGFSLDDKKLKRAGLDYWELVDLTVHDSWEAFLEALP--GGRLFLFT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494818081  83 TKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEA-VDCALKIPMQPHARSLNLAMSVAITTGEALRQIGYNEKR 155
Cdd:COG0219   80 TKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNAVAIVLYEALRQLGFPGLV 153
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 4-149 6.87e-76

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 222.71  E-value: 6.87e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   4 HIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLST 83
Cdd:cd18094    1 NIVLYEPEIPQNTGNIARTCAATGARLHLIEPLGFSLDDKRLKRAGLDYWDHVDLTVHDSWEAFLEALP--PGRLFLFTT 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494818081  84 KAKTCYTQICYQKNDVLLFGRESAGVPDYIHEAV-DCALKIPMQPHARSLNLAMSVAITTGEALRQI 149
Cdd:cd18094   79 KGTKPYTDFDFKPGDYLVFGRESTGLPEEILDAFpDRRLRIPMRPKVRSLNLSNSVAIVLYEALRQL 145
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 3-151 2.94e-45

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 145.52  E-value: 2.94e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   3 LHIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLS 82
Cdd:PRK10358   2 LNIVLFEPEIPPNTGNIIRLCANTGFRLHIIEPMGFAWDDKRLRRAGLDYHEFTAVTRHHDYAAFLEAEN--PQRLFALT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494818081  83 TKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEAV--DCALKIPMQPHARSLNLAMSVAITTGEALRQIGY 151
Cdd:PRK10358  80 TKGTPAHSAVSYQDGDYLMFGPETRGLPASILDALpaEQKIRIPMMPDSRSMNLSNAVSVVVYEAWRQLGY 150
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 3-140 6.20e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 126.49  E-value: 6.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081    3 LHIALFQPDIAGNTGTILRLSACFGLH-VHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRHFNRRLLLL 81
Cdd:pfam00588   2 LVVVLDNIQDPGNLGAIIRTAAAFGADgLILVEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 494818081   82 STKAKTcYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAI 140
Cdd:pfam00588  82 SLGGKS-LYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAI 139
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 14-148 5.98e-04

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 38.48  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   14 GNTGTILRLSACFGLHVhIIEPAGFNLSDRN-LKRAGLDYLEYASLERHIDWQHFIKNMRHFNRRLLLLSTKAKTcytqI 92
Cdd:TIGR00186 102 HNLGAILRTAEAFGVDG-VILPKRRSAPLNStVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQD----T 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   93 CYQKND----VLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEALRQ 148
Cdd:TIGR00186 177 LYQVKLtkplALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQ 236
 
Name Accession Description Interval E-value
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 3-155 1.27e-84

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 244.94  E-value: 1.27e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   3 LHIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLS 82
Cdd:COG0219    2 LHIVLYEPEIPQNTGNIIRLCAATGARLHLIEPLGFSLDDKKLKRAGLDYWELVDLTVHDSWEAFLEALP--GGRLFLFT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494818081  83 TKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEA-VDCALKIPMQPHARSLNLAMSVAITTGEALRQIGYNEKR 155
Cdd:COG0219   80 TKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNAVAIVLYEALRQLGFPGLV 153
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 4-149 6.87e-76

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 222.71  E-value: 6.87e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   4 HIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLST 83
Cdd:cd18094    1 NIVLYEPEIPQNTGNIARTCAATGARLHLIEPLGFSLDDKRLKRAGLDYWDHVDLTVHDSWEAFLEALP--PGRLFLFTT 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494818081  84 KAKTCYTQICYQKNDVLLFGRESAGVPDYIHEAV-DCALKIPMQPHARSLNLAMSVAITTGEALRQI 149
Cdd:cd18094   79 KGTKPYTDFDFKPGDYLVFGRESTGLPEEILDAFpDRRLRIPMRPKVRSLNLSNSVAIVLYEALRQL 145
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 3-151 2.94e-45

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 145.52  E-value: 2.94e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   3 LHIALFQPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRhfNRRLLLLS 82
Cdd:PRK10358   2 LNIVLFEPEIPPNTGNIIRLCANTGFRLHIIEPMGFAWDDKRLRRAGLDYHEFTAVTRHHDYAAFLEAEN--PQRLFALT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494818081  83 TKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEAV--DCALKIPMQPHARSLNLAMSVAITTGEALRQIGY 151
Cdd:PRK10358  80 TKGTPAHSAVSYQDGDYLMFGPETRGLPASILDALpaEQKIRIPMMPDSRSMNLSNAVSVVVYEAWRQLGY 150
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 3-140 6.20e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 126.49  E-value: 6.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081    3 LHIALFQPDIAGNTGTILRLSACFGLH-VHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWQHFIKNMRHFNRRLLLL 81
Cdd:pfam00588   2 LVVVLDNIQDPGNLGAIIRTAAAFGADgLILVEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 494818081   82 STKAKTcYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAI 140
Cdd:pfam00588  82 SLGGKS-LYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAI 139
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 4-141 9.60e-24

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 90.36  E-value: 9.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   4 HIALFQPDIAGNTGTILRLSACFGLH-VHIIEPAGFNLSDRnLKRAGLDYLEYASLERHIDWQHFIKNMRHFNRRLLLLS 82
Cdd:cd18082    1 HLVLDNIRSPGNIGSIFRTADAFGVEkIYLVGPTADIFDPK-AKRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGLE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494818081  83 TKAKTC---YTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAIT 141
Cdd:cd18082   80 LTDGSIplsEFKFKKPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIA 141
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 14-140 6.23e-18

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 75.16  E-value: 6.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  14 GNTGTILRLSACFGLHvHIIepagfnLSDR-----NLK--RAGLDYLEYASLERHIDWQHFIKNMRHFNRRLLLLSTKAK 86
Cdd:cd18095   12 GNLGTIIRTAAAFGVD-GVI------LSKGtvdpyNPKvvRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAADLDGG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 494818081  87 TCYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAI 140
Cdd:cd18095   85 SSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAI 138
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 14-148 4.63e-16

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 72.54  E-value: 4.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  14 GNTGTILRLSACFGLHvHIIEP----AGFNlsdRNLKRA---GLDYLEYAsleRHIDWQHFIKNMRHFNRRLLLLSTKAK 86
Cdd:COG0566  127 GNLGAILRSAAAFGVD-GVILPkrraDPYN---PKVVRAsagALFHVPVA---RVTNLADALEELKEAGFWVVGTDLDGE 199

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494818081  87 TCYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEALRQ 148
Cdd:COG0566  200 ASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLYEAARQ 261
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 14-148 6.05e-15

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 67.61  E-value: 6.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  14 GNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEY-----ASLERHIDWqhFIKNmrhfNRRLLLLSTKAKTC 88
Cdd:cd18104   12 GNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASLGAVFTlpvaeASSEETLAW--LKEN----KIRILATTPKAEKL 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  89 YTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEALRQ 148
Cdd:cd18104   86 YYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNVSVAAAILLYEALRQ 145
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 14-148 2.00e-11

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 58.63  E-value: 2.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  14 GNTGTILRLSACFGL-HVHIIEPA-GFNLSDRNLKRAGldylEYASLERHIDWQHFIKNMRHFNRRLL--LLSTKAKTcY 89
Cdd:cd18092   28 HNASAVLRTCDAFGVqDVHVIEPKnKFKKNRGVAMGAD----KWLDVHRHDSTEECLAALKEQGYRIVatSLSPDAVP-L 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 494818081  90 TQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEALRQ 148
Cdd:cd18092  103 DELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYELQRQ 161
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 3-140 8.49e-11

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 56.74  E-value: 8.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   3 LHIALFQPDIAGNTGTILRLSACFGLH-VHIIEPAGFNLSDRNLKRA--GLDYLE----YASLERhidwqhFIKNM---- 71
Cdd:cd18093    1 IRVVLVEPQHPGNIGAVARAMKNFGLSdLRLVNPRCDDPEEAARALAsgAEDVLEnakvYDTLEE------ALADCdlvv 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494818081  72 ------RHFNRRLLLLSTKAKTCYTQICYQKndV-LLFGRESAGVPDyihEAVDCA---LKIPMQPHARSLNLAMSVAI 140
Cdd:cd18093   75 attarpRGLRRPLLTPRELAELLKEHAAGGK--VaLVFGREDSGLTN---EELALCdllVTIPTNPEYPSLNLAQAVAI 148
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 12-140 1.91e-06

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 44.78  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  12 IAGNTGTILRLSACFGLHVHIIEPAGF-NLSDRNLKRAGLDYLeyASLERHI-DWQHFIKNMRHFNRRLLLLSTKAKTCY 89
Cdd:cd18108   10 IVGNIGAIVRTSLALGAAGIVLVDSDLaTVADRRLLRASRGYV--FSLPVVLaDREEAVAFLRDNDIPLMTLDADGDVPV 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 494818081  90 TQICYQKNDV-LLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAI 140
Cdd:cd18108   88 KELGDRPDRLaLVFGSEKGGPSGLFEEAAAGTVSIPMSSSTESLNVSVSAGI 139
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 1-140 1.56e-05

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 43.18  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   1 MTLHIALFQPDIAGNTGTILRLSACFGLH-VHIIEPAGFnLSDRNLKRA--GLDYLE----YASLE-------------- 59
Cdd:COG0565    2 DNIRVVLVEPQHPGNIGAAARAMKNFGLSdLRLVNPRGW-PDEEARAMAsgADDVLEnarvVDTLEealadcdlvvgtta 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  60 --RHIDWQHFikNMRHFNRRLLLLSTKAKTCytqicyqkndvLLFGRESAGVPDyihEAVDCA---LKIPMQPHARSLNL 134
Cdd:COG0565   81 rpRELRKPVL--TPREAAEELLARAAGGKVA-----------LVFGRERSGLTN---EELALCdalVTIPTNPEYPSLNL 144


                 ....*.
gi 494818081 135 AMSVAI 140
Cdd:COG0565  145 AQAVQV 150
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 13-140 1.59e-05

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 42.17  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  13 AGNTGTILRLSACFGL-HVHIiepAGFNLSDRNLKragldyLEYASL--ERHIDWQHF------IKNMRHFNRRLLLLST 83
Cdd:cd18097   11 AHNVGSIFRTADAAGVeKIYL---CGYTPTPPHPK------VAKTALgaEESVPWEHFedtleaVRALKARGYTIIALET 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 494818081  84 kAKTC--YTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAI 140
Cdd:cd18097   82 -TENSvpLHEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAV 139
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 99-144 1.69e-05

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 42.14  E-value: 1.69e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 494818081  99 VLLFGRESAGVPDYIHEAVDCALKIPMQP-HARSLNLAMSVAITTGE 144
Cdd:cd18109   94 ILVMGNEGHGISPEVLKLLTHRLTIPRYGkGAESLNVAVATAILLSE 140
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 15-140 4.32e-05

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 41.22  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  15 NTGTILRLSACFGLHvHIIepagfnLSDRN--------LKRA--GLDYLEYA---SLERhidwqhFIKNMRHFNRRLLLL 81
Cdd:cd18103   13 NLGAIIRSAEAFGVD-GVI------IPKRRsapltptvAKASagALEHLPIArvtNLAR------ALEELKEAGFWIYGA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 494818081  82 STKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAI 140
Cdd:cd18103   80 DGEAEKSLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGI 138
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 99-141 1.21e-04

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 39.82  E-value: 1.21e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 494818081  99 VLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAIT 141
Cdd:cd18091   99 VLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIA 141
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 14-145 2.11e-04

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 39.16  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081  14 GNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLERHIDWqHFIKNMRHFNRRLLLLSTKAKTC-YTQI 92
Cdd:cd18106   12 GNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGAHFRLPIYGNLSW-DDIPNYLPDDSKVFLADNNLPVQpYDSI 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 494818081  93 CYQKNDVLLF-GRESAGVPD----YIHEAVDCALKIPMQPHARSLNLAMSVAITTGEA 145
Cdd:cd18106   91 DYCSGPIVLViGGETHGVSPeaykLAHSTGGSRVHIPLANGVDSLNSAVAASILLFEM 148
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 5-145 2.80e-04

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 38.91  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   5 IALF-QPDIAGNTGTILRLSACFGLHVHIIEPAGFNLSDRNLKRAGLDYLEYASLER---HIDWQHFIKNMRH--FNRRL 78
Cdd:cd18107    2 VVLFdRPTSPGNLGTIIRSADALGAHGLVVTGHAADVYDPKTIRASTGSLFSLPIVRvpsNRELEDWVEARKArgTPLQL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494818081  79 LLLSTKAKTCYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEA 145
Cdd:cd18107   82 VGTDEHGDHQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYEA 148
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 14-148 5.98e-04

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 38.48  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   14 GNTGTILRLSACFGLHVhIIEPAGFNLSDRN-LKRAGLDYLEYASLERHIDWQHFIKNMRHFNRRLLLLSTKAKTcytqI 92
Cdd:TIGR00186 102 HNLGAILRTAEAFGVDG-VILPKRRSAPLNStVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQD----T 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   93 CYQKND----VLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEALRQ 148
Cdd:TIGR00186 177 LYQVKLtkplALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQ 236
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 5-140 4.56e-03

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 35.32  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494818081   5 IALFQPDIAGNTGTILRLSACFGlhvhiiEPAGFNLSDRNLKRAG----------LDYLEYASLERHIDWQHFIKNMRHF 74
Cdd:cd18098    3 IGIENPKTPKNVGTLWRAAGCLG------ASFVFTIGARYKRRKQstdtskawrhIPLFHYDDLEDLAEPLPFGAVLVAV 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494818081  75 NrrlllLSTKAkTCYTQICYQKNDVLLFGRESAGVPDYIHEAVDCALKIPMQphaRSLNLAMSVAI 140
Cdd:cd18098   77 E-----LTEGA-TPLPDFKHPDRAVYLLGPEDGGLPQEVLARCHHVVYLPTR---GSLNVAVAGSI 133
PRK10864 PRK10864
putative methyltransferase; Provisional
 99-148 5.06e-03

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 36.30  E-value: 5.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 494818081  99 VLLFGRESAGVPDYIHEAVDCALKIPMQPHARSLNLAMSVAITTGEALRQ 148
Cdd:PRK10864 294 VLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQ 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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