|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-384 |
9.27e-61 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 200.47 E-value: 9.27e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 16 VTIIALCCGLIVANIYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVG 95
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 96 TALADSPNVMLILCLMIGMS-SVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAA 174
Cdd:cd17324 81 AALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 175 GCMVFIAGVIYFAIPSRQPTHKTTYfkLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIA- 253
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSL--GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIg 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 254 LFALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVIAAVCFLpsLFELPYGIIVLALTGVFIDFAVQANMVLGQRAVYALE 333
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL--LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 494855714 334 PQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALL 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-354 |
3.24e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 127.01 E-value: 3.24e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 7 SAQPLSNTLVTIIALCCGLIVANIYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITL 86
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 87 AVSFLSLVGTALADSPNVMLILCLMIGMSSVSVQVLI-PLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFG 165
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 166 WRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTTYFKLLKSLkqlmISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREY 245
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLREL----LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 246 GLSQSEIAL-FALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVIAAVCFLpsLFELPYGIIVLALTGVFIDFAVQANMVL 324
Cdd:COG2814 239 GLSASAAGLlLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL--LLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340 350
....*....|....*....|....*....|.
gi 494855714 325 GQRAVYAL-EPQSRARLNAIYMTSIFVGGAV 354
Cdd:COG2814 317 LQALVAELaPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-388 |
1.08e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.89 E-value: 1.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 21 LCCGLIVANIYYA--QPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTAL 98
Cdd:cd17325 1 LSLALFLDMLGYGiiIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 99 ADSPNVMLILCLMIGMSSVSVQVL-IPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCM 177
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAaMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 178 VFIAGVIYFAIP--SRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIAL- 254
Cdd:cd17325 161 LLALVLALLLLPepRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 255 FALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVIAAVCFLPSLF--ELPYGIIVLALTGVFIDFAVQANMVLgqrAVYAL 332
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLatSFWLLLLLLALLGLGLGLVFPATLAL---LADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 494855714 333 EPQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLIGYLV 388
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-395 |
7.24e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 87.23 E-value: 7.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 15 LVTIIALCCGLIVANIYYAQPIIellAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLV 94
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPL---QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 95 GTALADSPNVMLILCLMIGM-SSVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFA 173
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 174 AGCMVFIAGVIYFAIpsrqpthkttyfkllkslkqlmisqpvlrqrSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIA 253
Cdd:COG2271 171 GLPGLLLALLRFWLL-------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 254 LFALVGAAGAVA-APIVGRLADK--GYTHQVSLLAKVIAAVCFLPSLF--ELPYGIIVLALTGVFIDFAVQANMVLGQRA 328
Cdd:COG2271 220 LLLSLPFLAGIVgSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALlpSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494855714 329 VyalEPQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLIGYLVTTKKQSK 395
Cdd:COG2271 300 F---PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
35-389 |
1.84e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 83.01 E-value: 1.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVLIPLAAHLS-SDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQP 193
Cdd:cd17320 100 GAAAGSVVARAIVRDLySGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 194 THKTTYF--KLLKSLKQLmISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIAL-FALVGAAGAVAAPIVG 270
Cdd:cd17320 180 EEKRKPLlsSLLRAYKRV-LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLlFALNAIALILGSLLNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 271 RLADKGYTHQVSLLAKVIAAVC-FLPSLFELPYGIIVLALTGVFIDFAVQANMVLGQRAVYALE--PQSRARLNAIYMTS 347
Cdd:cd17320 259 RLVRRFGPRRLLRLGLLLLLAAaLVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEpfPHVAGTASALLGFL 338
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 494855714 348 IFVGGAVGSLIASPLYEaGGWTGIALVATGMPLISLIGYLVT 389
Cdd:cd17320 339 QFLIGALAGALVGLLPN-GTALPMGLLILVLGLLALLLLILL 379
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-397 |
1.87e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.23 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:COG2223 26 VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSV-QVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQP 193
Cdd:COG2223 106 GGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 194 THKTTYFKLLKSLKQlMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFALVGAAGAVAA-PIVGRL 272
Cdd:COG2223 186 GAAAAAKASLRDQLE-ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGrPLGGWL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 273 ADKGYTHQVSLLAKVIAAVCFLP-SLFELPYGIIVLALTGVFIdfavqaNMVLGQRAVYAL-----EPQSRARLNAIYMT 346
Cdd:COG2223 265 SDRIGGRRVLLIVFALMALGLLLlALALGSLWLFLVLFLLLGL------ALGGGNGAVFALvpdifPTKNAGAVYGLVGA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 494855714 347 SIFVGGAVGSLIASPLYEA-GGWTGIALVATGMPLISLIGYLVTTKKQSKAV 397
Cdd:COG2223 339 AGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-356 |
2.03e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.69 E-value: 2.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 16 VTIIALCCGLIVANIYYAQPIIelLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVG 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLL--LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 96 TALADSPNVMLILCLMIGM-SSVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAA 174
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 175 GcmVFIAGVIYFAIPSRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPV---VLAREYGLSQSE 251
Cdd:pfam07690 159 I--LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTylpLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 252 IA-LFALVGAAGAVAAPIVGRLADKGYTHQ-----VSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQANMVLG 325
Cdd:pfam07690 237 AGlLLGLGGLLGAIGRLLLGRLSDRLGRRRrlllaLLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340 350
....*....|....*....|....*....|.
gi 494855714 326 QRAVyalEPQSRARLNAIYMTSIFVGGAVGS 356
Cdd:pfam07690 317 SDLA---PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-387 |
1.14e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.61 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 19 IALCCGLIVANIYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTAL 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 99 ADSPNVMLILCLMIGMSSVSVQVLIP-LAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADH--FGWRAVFYFAAG 175
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLaLIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 176 CMVFIAGVIYFAIPSRQ----PTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSE 251
Cdd:cd06174 161 LALLAAILLLLVVPDPPesarAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 252 IALFALVGAAGAVA-APIVGRLADKGYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQANMVLGQRAVY 330
Cdd:cd06174 241 AGLLLSLFGLAGALgSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 494855714 331 ALEPQSRARLNAIYMTSIFVGGAVGSLIASPLY-EAGGWTGIALVATGMPLISLIGYL 387
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-389 |
4.17e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 66.85 E-value: 4.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 30 IYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILC 109
Cdd:cd17489 12 FYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 110 LMIGMS-SVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFaI 188
Cdd:cd17489 92 LIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL-V 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 189 PSRQPTHKTTYFKLLKSLKQLMisQPVLRQRSLFQALMFASFSLFWTSVPVvLAREYGLSQSEIAlFALVGAAGAVAAPI 268
Cdd:cd17489 171 KDPPPVAAEEAEAGTRAFRRLV--EKKVLPPALILFLASIAYGAISTFLPL-YAAERGISNAGLF-FTVYAIALLLSRPF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 269 VGRLADKGYTHQVSLLAKVIAAVCFLPSLFE--LPYGIIVLALTGVFIDFAVQANMVLgqrAVYALEPQSRARLNAIYMT 346
Cdd:cd17489 247 SGKLSDRKGPKTVIIPGLLLLALGLLLLSFAgsPWMLLLAAVLYGLGFGLLFPALQAL---AVDLVPPHRRGAANGTFFI 323
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 494855714 347 SIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLIGYLVT 389
Cdd:cd17489 324 FFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
15-254 |
1.18e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.59 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 15 LVTIIALCCGLIvANIYYaqPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLV 94
Cdd:cd17323 3 IISFLTFVVTFG-SSIYS--PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 95 GTALADSPNVMLILCLMIGMSSVSVQVLIPLA-AHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFa 173
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTiADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 174 agcMVFIAGVIYFAIpsrqpthkttYFKLlkslkqlmisqPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIA 253
Cdd:cd17323 159 ---LAIISGFCLILI----------FLFL-----------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVG 214
|
.
gi 494855714 254 L 254
Cdd:cd17323 215 L 215
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
35-384 |
2.25e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.82 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd17474 20 PILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVL-IPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADhFGWRAVFYFAAGCMVFIAGVIYFAIPSRQP 193
Cdd:cd17474 100 GAAGLGPLaLTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 194 THKTTYFKLLKSLKQLMiSQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEI-ALFALVGAAGAVAAPIVGRL 272
Cdd:cd17474 179 KAKSSSATKLRDLKKAL-RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIgLLFAGWSVLLALGSLFVGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 273 ADKGYTHQVSLLAKVI---AAVCFLPSLFELPYGIIVLALTGVF--IDFAVQANMVLGqravyALEPQSRARLNAIYMTS 347
Cdd:cd17474 258 LKKRFGARRILVIGLLlyaLSLLLLGFVPSLALLLIAIVLFGLGlgLNLPLLTTLVTE-----LAPEEERGTASSLYNFV 332
|
330 340 350
....*....|....*....|....*....|....*..
gi 494855714 348 IFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17474 333 RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-384 |
3.14e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 3.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 1 MTQTGVSAQPLSNTLVTIIALCCGLIVAN----IYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLI 76
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNlrpaITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 77 ENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMSSVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPI 156
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 157 SSLIADHFGWRAVFYFAAGcMVFIAGVIYFAIPSRQPTHKTtyfkllkSLKQLMISQPVLRQRSLFQ-ALMFASFSLFWT 235
Cdd:COG2807 161 TVPLAAALGWRGALAVWAL-LALLALLLWLPLLRRRPAAAA-------AAPAAASLRSLWRSPLAWLlTLFFGLQSLLYY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 236 SV----PVVLaREYGLSQSE----IALFALVGAAGAVAAPIV-GRLADKGYTHQVSLLAKVIAAVCFLPSLFELPYGIIV 306
Cdd:COG2807 233 AVvawlPPIL-RDAGLSAATagllLSLFQLAGIPGSLLVPLLaDRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAV 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494855714 307 LALTGVFIDFAVqANMVLGQRAVyalEPQSRARLNAIYMTSIFVGGAVGSLIASPLYEA-GGWTGIALVATGMPLISLI 384
Cdd:COG2807 312 LLGLGQGGLFPL-ALTLIGLRAR---TPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAVLMLV 386
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
28-388 |
3.06e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.97 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 28 ANIYYAQPIIellAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLI 107
Cdd:cd17319 20 VNISVAAPTI---MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 108 LCLMIGMSSVSVQVLIPLA-AHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFaAGCMVFIAGVIyf 186
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKAlAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII-EGLLGLLLAVL-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 187 aipsrqpthkttYFKLLKSLKQLMISQpvlrqrslFQALMFASFSLFWTsvPVVLAREYGLSQSEIALFALV-GAAGAVA 265
Cdd:cd17319 174 ------------WWFYLRQVWGLALGY--------FGINYALYGLLTWL--PTYLKQARGFSLKQVGLLAAIpFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 266 APIVGRLADKGYT-----HQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQANMVLGQRavyALEPQSRARL 340
Cdd:cd17319 232 MILGGRLSDRLLRgarrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPAD---LLPGEAAATA 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 494855714 341 NAIYMTSIFVGGAVGSLIASPLYEA-GGWTGIALVATGMPLISLIGYLV 388
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-387 |
3.17e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.01 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 40 LAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM-SSVS 118
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFgGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 119 VQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADhFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTT 198
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 199 YFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIA-LFALVGAAGAVAAPIVGRLADKGY 277
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGlLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 278 THQVSLLAKVIAAVCFLPSLFELpyGIIVLALTGVFIDFAVQANMVLGQRAVYALEPQ-SRARLNAIYMTSIFVGGAVGS 356
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFAN--TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPdKRGSYMGFYALAWGLGRAIGP 342
|
330 340 350
....*....|....*....|....*....|.
gi 494855714 357 LIASPLYEAGGWTGIALVATGMPLISLIGYL 387
Cdd:cd17329 343 LVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
40-389 |
4.70e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 57.78 E-value: 4.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 40 LAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMSSVSV 119
Cdd:TIGR00710 31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 120 QVLI-PLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTT 198
Cdd:TIGR00710 111 SVISqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 199 YFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIA-LFALVGAAGAVAAPIVGRLADK-- 275
Cdd:TIGR00710 191 QISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGlLFALNIIAMIFGGFLNGRFIKKwg 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 276 GYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALtGVFIDFAVQANMVLGQRAVYALEPQSRA--RLNAIYMTSIFVGGA 353
Cdd:TIGR00710 271 AKSLLRMGLILFAVSAVLLEITAILGLGSWAMII-GPMMFVGIGNSMISSIAMAYALEDFPHVagTASALFGTLRLVLGA 349
|
330 340 350
....*....|....*....|....*....|....*.
gi 494855714 354 VGSLIASPLYEAGGWTGIALVATGMPLISLIGYLVT 389
Cdd:TIGR00710 350 IVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
56-384 |
6.78e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.23 E-value: 6.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 56 SLTQIGYALGLF------FLVP---LADLIENKRLMLITLAVSFLSLVGTALADSPnVMLILCLMIGMSSVSVQVLIPLA 126
Cdd:cd17472 30 TPTLIGLALGIYgltqaiFQIPfglLSDRIGRKPVILFGLLLFIAGSLLAAYATSI-YGLILGRALQGSGAISSVVMALL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 127 AHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPsRQPTHKTTYFKLLKSL 206
Cdd:cd17472 109 ADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP-DPPKIVQISEKEKKKL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 207 KQLMISQPVLRqrsLFQALMFASFSL--FWTSVPVVLAREYGLSQSEIALFALVGAAGAVAAPIVGRLADK-GYTHQVSL 283
Cdd:cd17472 188 KKLLKNKRLLR---LDFSIFILHFVLmaFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKkGKMKQVFV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 284 LAKVIAAVCFLPSLFELP-YGIIVLALTGVFIDFAVQ---ANMVLGQRAvyalEPQSRARLNAIYMTSIFVGGAVGSLIA 359
Cdd:cd17472 265 SSILLIAVGFLLLLFAATsLWLLIIGLIIFFIGFNLLealLPSLVSKIA----PKEYRGTAMGIYNTSQFLGSFLGGALG 340
|
330 340
....*....|....*....|....*
gi 494855714 360 SPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17472 341 GLLWGLLGYSSVFLTILILALLWLL 365
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
60-189 |
1.47e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 53.04 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 60 IGYALGLFFLVPLA----DLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMSSVSVQVLIP-LAAHLSSDEK 134
Cdd:TIGR00880 5 AGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAaLIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494855714 135 RGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIP 189
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-189 |
1.64e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.83 E-value: 1.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 1 MTQTGVSAQPLSNTLVTIIALCCGLIVANIYYAQPiieLLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKR 80
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAP---AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 81 LMLITLAVSFLSLVGTALADSPNVMLILCLM--IGMSSVsVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISS 158
Cdd:TIGR00895 84 VLLWSILLFSVFTLLCALATNVTQLLILRFLagLGLGGL-MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAG 162
|
170 180 190
....*....|....*....|....*....|.
gi 494855714 159 LIADHFGWRAVFYFAAGCMVFIAGVIYFAIP 189
Cdd:TIGR00895 163 WLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-273 |
6.83e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.66 E-value: 6.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 1 MTQTGVSAQPLSNTLVTIIALCCGLIVANIYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKR 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 81 LMLITLAVSFLSLVGTALADSPNVMLILCLMIGMS-SVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSL 159
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 160 IADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPV 239
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270
....*....|....*....|....*....|....
gi 494855714 240 VLAREYGLSQSEIALFALVGAAGAVAAPIVGRLA 273
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLAL 274
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
35-384 |
7.41e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 7.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd17477 17 PLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVLIPLA-AHLSSDEKRGQVLGnIMAGLLLGILLARPISSLIADHFGWRAvFYFAAGCMVFIAGVIYF---AIPS 190
Cdd:cd17477 97 GLAGLFVVSESWlNALATNENRGRVLG-LYSTVLGLGFALGPLLLALVGTAGALP-FLIAAVLLLLALVPLLLtrrAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 191 RQPTHKTTYFKLLKSLKQLMISqpvlrqrslfqALMFASF-SLFWTSVPVVLAREyGLSQSEIALFALVGAAGAVAAPI- 268
Cdd:cd17477 175 IEEAESISLRRLLRIAPLALLG-----------AFVAGFLeGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWp 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 269 VGRLADKGYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQ----ANMVLGQRavyaLEPQSRARLNAIY 344
Cdd:cd17477 243 LGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlytlALALAGDR----LPGDELVAANAAL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 494855714 345 MTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17477 319 LLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
19-181 |
9.31e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.36 E-value: 9.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 19 IALCCGLIVANIYYAQP---IIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVG 95
Cdd:cd17365 1 LALCFLIIVLDGFDLAVmgfVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 96 TALADSPNVMLILCLMIGMS-SVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAA 174
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
....*..
gi 494855714 175 GCMVFIA 181
Cdd:cd17365 161 VPPLILL 167
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
35-359 |
9.80e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 53.35 E-value: 9.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd17504 17 PALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFaIPSRQPT 194
Cdd:cd17504 97 GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL-IDLRLLR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 195 HKTTYFKLLKSLkqlmisqpvlrqrsLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFAL-VGAAGAVAAPIVGRLA 273
Cdd:cd17504 176 RRNVLLANITAL--------------LAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLpGALVMLIAGPLAGRLI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 274 DKGYTHQVSLLAKVIAAVCFLPSLFeLPYGIIVLALTGVFID------FAVQANMVlgqraVYALEPQSRARLNAIYMTS 347
Cdd:cd17504 242 ARVGPRRVLLIGLVISAVGLLLLAL-LHSSLWALVVALLLIGiglglaFASLPNIV-----VESVPPDRTGIATGMNTVL 315
|
330
....*....|..
gi 494855714 348 IFVGGAVGSLIA 359
Cdd:cd17504 316 RTIGSAIGPAIA 327
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
39-388 |
1.97e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 39 LLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLIT---LAVSFLSLVGTALADSPNVMLILCLMIGMS 115
Cdd:cd06173 24 WLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllRALLAAVLALLALLGSLSLWLLLVLAFLLG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 116 SVSV------QVLIPLaahLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMvFIAGVIYFAIP 189
Cdd:cd06173 104 IASAffgparQALLPE---LVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSF-LLSALLLLFIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 190 ----SRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFALVGAAGAVA 265
Cdd:cd06173 180 rpppAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 266 APIV-GRLADKGYTHQVSLLAKVIAAVCFLPS--LFELPYGIIVLALTGVFIDFAVQANMVLGQRAVyalEPQSRARLNA 342
Cdd:cd06173 260 GALLlGRLSKRRRRGRLLLIGALLLGLALLVLglSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV---PDELRGRVFS 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 494855714 343 IYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLIGYLV 388
Cdd:cd06173 337 VYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
79-384 |
3.81e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 79 KRLMLITLAVSFLSLVGTALADSPNV-MLILCLMIGMSSVSVQVLIPLAAHL--SSDEKRGQVLGNIMAGLLLGILLARP 155
Cdd:cd17471 63 KPLILLALLAGALGYLLFAFLRNYWVlLLVGVVLLSLGAAAFPQLFALAREYadRSSGRDATLFNSVLRAAFSLAWVIGP 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 156 -ISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTTyfkLLKSLKQLMISQPVLRQRSLFQALMFASFSLFW 234
Cdd:cd17471 143 pLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKA---TPASSLVKAPVNRRLLLLFAAFTLLFAANSMYI 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 235 TSVPVVLAREYGLSQSEIA-LFALVGAAGAVAAPIVGRLADKGYTHQVsLLAKVIAAVCF--LPSLFELPYGIIVL-ALT 310
Cdd:cd17471 220 IAMPLYVTNELGGSESWVGlLFGLAAALEIPIMLLAGLLAKRFGKRRL-LLAGFLAGVLFylGLALATSLWQLIALqLLN 298
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494855714 311 GVFIDFAVQANMVLGQravyALEPQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17471 299 AIFIGITAGLGISYFQ----DLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
43-366 |
1.65e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.48 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 43 EVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMSSVSVQ-V 121
Cdd:cd17321 25 DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMpA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 122 LIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFaagcMVFIAGVIYFAIPSRQPThkttyfk 201
Cdd:cd17321 105 SLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI----NVPIGLVALLLARTFSGA------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 202 llkslkqlmisqpvlrqrSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIAL-FALVGAAGAVAAPIVGRLADKGYTHQ 280
Cdd:cd17321 174 ------------------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLaLLPLALAMLVAAPLAGRLADRFGPRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 281 VSLLAKVIAAV-----CFLPSLFELPYGIIVLALTGVFIDFAVQANMVLgqrAVYALEPQSRARLNAIYMTSIFVGGAVG 355
Cdd:cd17321 236 VLVAGLLLTAVgllllALLGADSSVWLLLPGLVLLGLGLGLFATPLTNA---ALSSVPKEKAGAASGILNTARQLGGALG 312
|
330
....*....|.
gi 494855714 356 SLIASPLYEAG 366
Cdd:cd17321 313 VALLGALLTAG 323
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-396 |
1.75e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.47 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 13 NTLVTIIALCCGLIVANIYYAQ--PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSF 90
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALwgPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 91 LSLVGTALADSPNVMLILCLMIGMSSVSVQVLI-PLAAHLSSDEKR------------GQVLGNIMaglllgillarpIS 157
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAAnPYVAALGPETAAsrlnllhaffslGALLGPLL------------GG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 158 SLIADHFG--WRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTTYFKLLKSLKQLMiSQPVLRQRSLFQALMFASFSLFWT 235
Cdd:COG0738 153 LLILLGLSlsWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLL-KNPRLLLGGLAIFLYVGAEGAIGD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 236 SVPVVLAREYGLSQSEIALFALVGAAGAVAAPIVG-RLADK-GYTHQVSLLAkVIAAVCFLPSLF--ELPYGIIVLALTG 311
Cdd:COG0738 232 WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGgFLLKRfGPVRLLRLSA-LLAAVGLLLALLapGPWLALIGLALVG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 312 VFIDFAVQANMVLGQRAVyalePQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLIGYLVTTK 391
Cdd:COG0738 311 LGLSLMFPTIFSLALDGL----GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
....*
gi 494855714 392 KQSKA 396
Cdd:COG0738 387 KRRKK 391
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
34-188 |
2.00e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.57 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 34 QPIIEL----LAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILC 109
Cdd:cd17391 221 EPILTLyirqLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILR 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 110 LMIGMS-SVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAI 188
Cdd:cd17391 301 FLLGLAtGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-389 |
3.43e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 3.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 18 IIALCCGLIVAN---IYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLV 94
Cdd:cd17355 4 VLAVTFLILILSwgiRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 95 GTALADSPNVM--LILCLMIGMSSVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYF 172
Cdd:cd17355 84 LLALATSLWQLylLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 173 AAGCMVFIAGVIYFAIPsRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWTSVPVV-----LAREYGL 247
Cdd:cd17355 164 LALLALLVLVPVLLLLR-RRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIvhlvpYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 248 SQSEIA-LFALVGAAGAVAAPIVGRLADKgYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQANMVLGQ 326
Cdd:cd17355 243 SPAAAAvALALIGLFNIVGRLLSGWLGDR-YSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494855714 327 RAVYALEPQSR-ARLNAIYMTSIFVGGAVGSLIASPLYEA-GGWTGIALVATGMPLISLIGYLVT 389
Cdd:cd17355 322 ALAARYFGARSyGTLFGLVFAPHQLGSALGPWLGGLLYDRtGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-388 |
5.04e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 5.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 44 VGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMSSVSVQVL- 122
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLa 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 123 IPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADhFGWRAVFYFAAGCMVFIAGVIYFaIPSRQPTHKTTYFKL 202
Cdd:cd17473 110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLF-LPEPARKSKSAASPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 203 LKSLKQLMIsqpvlRQRSLFQALMFASFSLFW---TSVPVVLAREYGLSQSEIALFALVGAAGAVAAPIVGRLADKGYTH 279
Cdd:cd17473 188 AATAAALPW-----KRVLPIYFLAFLAMLLFYvipIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 280 QVSL-LAKVIAAVCFLpsLFELPYGIIVLALTGVFIDFAVQANM-VLGQRAVYALEPQSRARLNAIYMTSIFVGGAVGSL 357
Cdd:cd17473 263 RRLLaIGFALMALGFL--LLALASGLWVVLLGAILAGLGFGLLLpTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
330 340 350
....*....|....*....|....*....|..
gi 494855714 358 IASPL-YEAGGWTGIALVATGMPLISLIGYLV 388
Cdd:cd17473 341 VLGPLvNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
44-368 |
6.83e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.57 E-value: 6.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 44 VGLSAHSASLIVSLTQI-----GYALGLFFLVP----LADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd17503 17 VALPTIMGDLGASLDTVqwvitSYLLALAIMIPlsgwLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSvsvQVLIPLAAHLSSD----EKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFaagcMVFIAGVIYFAIPS 190
Cdd:cd17503 97 GG---GVLIPLAQTILLRiyppEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI----NLPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 191 RQpthkttyFKLLKSlkqlmisqPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFAL-VGAAGAVAAPIV 269
Cdd:cd17503 170 LD-------LRLFKD--------RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLApGGLASAILSPLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 270 GRLADK-GYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQ-ANMVLGQRAVYALEPQSRARLNAIYMTS 347
Cdd:cd17503 235 GRLLDKfGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGlVFMPLNTLALNSLPPEQIGDATALFNTI 314
|
330 340
....*....|....*....|.
gi 494855714 348 IFVGGAVGSLIASPLYEAGGW 368
Cdd:cd17503 315 RQLGGSIGTALLATLLTNRTQ 335
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
35-384 |
7.51e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 7.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPT 194
Cdd:cd17478 97 GSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 195 HKTTYFKLLKSLKQLMISQPVLR------QRSLFQALMFASFSLFWTsvpvvlAREYGLSQSEIALFaLVGAAGAVAAPI 268
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLlliivfLRSWVLSSLTTFLPFYLV------QRGYSLVFAGLLLS-LFLFAGAIGTLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 269 VGRLADKGYTHQVSLLAKVIAAVCFLPSLF-ELPYGIIVLALTGVFIDFAVQANMVLGQRAVyalePQSRARLNAIYMTS 347
Cdd:cd17478 250 GGPLSDRFGRRRVIIASLLLAAPFLLLFLLtPGIWSYILLVLAGFLLFASFPVTVVLAQELL----PGNVGLASGLMMGL 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 494855714 348 IFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17478 326 SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
39-355 |
1.29e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 46.91 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 39 LLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALA-DSPNVMLILCLMIGMSSV 117
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 118 SVQVLIPLAAHLSSDEKRGQVL------GNiMAGLLLGILLARPISSLIAD-----HFGWRAVFYFAAGCMVFIAGVIYF 186
Cdd:TIGR00886 107 SFASCMPWISFFFPKKIQGTALglaagwGN-MGGGVAQFVMPPIIGSLIFGggqpaHLAWGWAFVIVPAGILLLPALLIF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 187 AIPSRQPTHKTTYFKLlKSLKQLmisqPVLRQR-----SLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFALVGAA 261
Cdd:TIGR00886 186 FVGADTPPGKPATGKL-SFKEAL----KVFGNRhtwilALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGF 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 262 GAVAA-PIVGRLADKGYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQANMvlGQRAVYALEPQSRARL 340
Cdd:TIGR00886 261 LGSLArPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGA--GNGSTFALVPHIFRRA 338
|
330
....*....|....*
gi 494855714 341 NAIYMTSIFVGGAVG 355
Cdd:TIGR00886 339 TGAVSGLIGAIGNLG 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
45-384 |
1.29e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.80 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 45 GLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMSSVSVQVLIP 124
Cdd:cd17330 30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 125 LAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFaipsrqpthkttyfkLLK 204
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLF---------------FLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 205 SLKQLMISqpvlrqrslfQALMFASFSLFWTSVPVVLAREYGLSQSEIALFALVG--AAGAVAAPIVGRLADKGYTHQVS 282
Cdd:cd17330 175 PLRRLLLV----------YFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgiAGILAQLLLIPRLAKRLGERKLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 283 LLAKVIAA-----VCFLPSLFELPYGIIVLALTGVFIDFAVQAnMVLGqravyALEPQSRARLNAIYMTSIFVGGAVGSL 357
Cdd:cd17330 245 RLGLLLAIiglllLPFASSVPLLVLAAAILAFGTGIVFPALSA-LLSK-----SVPSKEQGKAQGIIQSLQSLARIIGPL 318
|
330 340
....*....|....*....|....*..
gi 494855714 358 IASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17330 319 LAGPLYSFLGPGVPFLLAAGLLLIALF 345
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-187 |
1.46e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 12 SNTLVTIIALCCGLIVANIYYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFL 91
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 92 SLVGTALADSPNVMLILCLMIGMSSVSVQV-LIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVF 170
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVpLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 494855714 171 YFAAGCMVFIAGVIYFA 187
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
220-392 |
2.55e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 220 SLFQALMFASFSLFWTSVPVVLAREYGLSQSEIAL-FALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVIAAVCFLPSLF 298
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLlLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 299 elPYGIIVLALTGVFIDFAVQANMVLGQRAVYAL-EPQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATG 377
Cdd:pfam07690 82 --ASSLWLLLVLRVLQGLGAGALFPAALALIADWfPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|....*
gi 494855714 378 MPLISLIGYLVTTKK 392
Cdd:pfam07690 160 LSLLAAVLLLLPRPP 174
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
45-384 |
4.10e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 4.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 45 GLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMS-SVSVQVLI 123
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGiGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 124 PLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHF----GWRAVFYFAAgcmvFIAGVIYFaipsrqpthktty 199
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGA----LPALLALL------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 200 fkLLKSLKQLMisqpvlrqrsLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFALVGAAGAVAAPIV-GRLADKGYT 278
Cdd:cd17316 175 --LRRRTLLLI----------LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIaGLLSDRIGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 279 HQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAVQANMVLGQRAVYALEP-QSRARLNAI-YMTSIFVGGAVGS 356
Cdd:cd17316 243 KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLsYNLGRLGGGGAPP 322
|
330 340
....*....|....*....|....*...
gi 494855714 357 LIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17316 323 LIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
46-254 |
9.25e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.13 E-value: 9.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 46 LSAHSASLIVSLTQIGYALG------LFFLVPL---ADLIEN-KRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMS 115
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGaygisqMLLRIPLgilSDRIGKrKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 116 SVSVQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAgcmvfIAGVIYFAIPSRQPTH 195
Cdd:cd17490 99 AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAA-----LAGVLGFILSLFIKEE 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494855714 196 KTTYFKLLKSLKQL--MISQPVLRQRSLFQAL-MFASFSLFWTSVPvVLAREYGLSQSEIAL 254
Cdd:cd17490 174 RREKKPVLTELKELlsVLKDKKLLFFSLLAILqQMITFSTTFGFTP-LIAKQLGASSFQLGL 234
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
165-384 |
1.31e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 165 GWRAVFYFAAGCMVFIAGVIYFAIPSRqPTHKTTYFKLLKSLKQLMiSQPVLRQRSLFQALMFASFSLFWTSVPVVLARE 244
Cdd:COG2211 181 GYRLTALIFAVLGLLAFLLTFFGTKER-PVPEEEKVSLKESLKALL-KNRPFLLLLLAYLLFFLALALVAALLLYYFKYV 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 245 YGLSQSEIALFALVGAAGA-VAAPIVGRLADKGYTHQVSLLAKVIAAVCFLPSLF----ELPYGIIVLALTGVF------ 313
Cdd:COG2211 259 LGLSAALVGLLLALYFLAAlLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgpgNLWLLLVLAALAGIGlgailv 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 314 IDFAVQANMV------LGQRAvyalepqsRARLNAIYMTSIFVGGAVGSLIASPLYEAGGW-----------TGIALVAT 376
Cdd:COG2211 339 LPWAMLADVVdydewkTGRRR--------EGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspsalTGIRLLFF 410
|
....*...
gi 494855714 377 GMPLISLI 384
Cdd:COG2211 411 LLPAVLLL 418
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
31-186 |
1.61e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 31 YYAQPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCL 110
Cdd:cd17370 216 NFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFI 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494855714 111 MIGMSSVSVQVLIP-LAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAgCMVFIAGVIYF 186
Cdd:cd17370 296 LWGLYMGAQESIERaAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSA-VLALIALLLLL 371
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
17-189 |
1.98e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.92 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 17 TIIALCCGLIVANIYYAQPIIEL--LAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRL--MLITLAVSFLS 92
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLpsYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLylYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 93 LVGTALADSPNVMLILCLMIGMSSVSVQVLIPL-AAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFG-WRAVF 170
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPViLADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAF 343
|
170
....*....|....*....
gi 494855714 171 YFAaGCMVFIAGVIYFAIP 189
Cdd:cd17352 344 YFC-GACLLLSGVLLFLLP 361
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
23-206 |
2.26e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.38 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 23 CGLIVANIYYAQPIIELLAPEVGLSAHSAS---LIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALA 99
Cdd:cd06179 3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSnstWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 100 DSPNVMLILCLMIGMSSVSVQVLIPLAAHLSSDEKRGQVLGnIMAGLLLGILLARPISS---LIADHFGWRAVFYFAAGc 176
Cdd:cd06179 83 KSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQG-VVNLVASPGSALGPLIAgalVEANAAGWRWIFYINAI- 160
|
170 180 190
....*....|....*....|....*....|...
gi 494855714 177 MVFIAGVIYFAI---PSRQPTHKTTYFKLLKSL 206
Cdd:cd06179 161 FNALALILLFFFyhpPPRPQLHGSSTRQKLKRL 193
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
18-384 |
2.72e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 18 IIALCCGLIVANIYYAQPIIELLapevGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTA 97
Cdd:cd17353 11 LMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 98 LADSPNVMLILCLMIGMSSVSVQVLIPLAAHLS-SDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAA-- 174
Cdd:cd17353 87 FAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKwFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGii 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 175 -GCMVFIAGVIY-FAIPSRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFqaLMFASFSLFWTSVPVVLAREYGLSQSEI 252
Cdd:cd17353 167 fLIIIVIGAFLIrDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFW--LLWLMFFLNATAGLMLIGQAKPIGQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 253 ALFALVGAAGAVAAPIV--------GRLADK-GYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTGVFIDFAvqanmv 323
Cdd:cd17353 245 GLDAGIAALAVSILSIFngggrpfwGWLSDKiGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYG------ 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 324 lgqrAVYALEP---------QSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLI 384
Cdd:cd17353 319 ----GGFALFPaltadffgtKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALA 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
224-396 |
3.55e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 3.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 224 ALMFASFSL--FWTSVPVVL---AREYGLSQSEIA-LFALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVIAAVCFLpsL 297
Cdd:COG2807 22 AIVLVALNLrpAITSVGPLLpeiRADLGLSATQAGlLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL--L 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 298 FELPYGIIVLALTGVFIDFAVQANMVLGQRAVYALEPQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATG 377
Cdd:COG2807 100 RSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL 179
|
170
....*....|....*....
gi 494855714 378 MPLISLIGYLVTTKKQSKA 396
Cdd:COG2807 180 LALLALLLWLPLLRRRPAA 198
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
35-356 |
3.58e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALAD-SPNVMLILCLMIG 113
Cdd:cd17341 20 PLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVsSYWGLLVLGFLLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 114 MSSVSVQVLIPLAAHLSSDEKRGQVLGNI----MAGLLLGILLARPISSLIA---DHFGWRAVFYFAAGCMVfIAGVIYF 186
Cdd:cd17341 100 FAGANFASGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLIAGAIVfdgGFVGWRNAFFVPGILLA-IAAVLVL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 187 AIPSRQPTHKTTYFKLLKSLKQLmISQPVLRQRSLFQALMFASFSLFWTSVPVVLAREYGLSQSEIALFALVGAAGAVAA 266
Cdd:cd17341 179 LFGDDLPTGKASALEFLKVQLAV-LKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 267 -PIVGRLADKGYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLALTgVFIDFAVQANMVLGQRAVYALEPQSRARLNAIYM 345
Cdd:cd17341 258 rPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLF-LALFVALGLGAGAGNGSVFRMVPFIFRRELGAVT 336
|
330
....*....|.
gi 494855714 346 TSIFVGGAVGS 356
Cdd:cd17341 337 GLVGAIGGLGG 347
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
35-367 |
1.74e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.37 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 35 PIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM 114
Cdd:cd06180 20 PLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVLIP-LAAHLSSDEKRGQVLGNIMA-GLLLGILLARPISSLIADHFGWRAVfYFAAGCMVFIAGVIYFAipsrq 192
Cdd:cd06180 100 ASAFVFVFGSnLVLHHATAAGRGHLIGLLFAgVGLGIALSGLLVPAGLGGGLSWRAG-WLALALLSAVLLLLSFL----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 193 pthkTTYFKLLKSLKQLMISQPVLRQRSLFQALMF-----ASFSLFWTSVPVVLAREYGLSQSEIALFALVGAAGAVAAP 267
Cdd:cd06180 174 ----LLRRGPSAPTEASAAESAPGLNRPLWRLALAyglfgFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 268 IVGRLADKGYTHQVSLLAKVIAAVCFLPSLfeLPYGIIVLALTGVFIDFAVQANMVLGQRAVYALEPQSRARLNAiYMTS 347
Cdd:cd06180 250 LWGALSDRWGTRRALAANLLVQAVGVLLPL--LSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALA-LMTA 326
|
330 340
....*....|....*....|.
gi 494855714 348 IF-VGGAVGSLIASPLYEAGG 367
Cdd:cd06180 327 SFgVGQILGPLLAGWLADATG 347
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-186 |
2.27e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 13 NTLVTIIALCCGLIVANIYYAqPIIELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLS 92
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTT-FLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 93 LVGTALADSPNVMLILCLMIGMSSVSVQVLIPLAAHLSS---DEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAV 169
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAElfpTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
170
....*....|....*..
gi 494855714 170 FYFAAGCMVFIAGVIYF 186
Cdd:cd17316 337 PALILALLAIVALIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-115 |
3.28e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.50 E-value: 3.28e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494855714 44 VGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGMS 115
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG 330
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-248 |
3.85e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 39.13 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 33 AQPIIellAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMI 112
Cdd:PRK11102 13 ALPVI---AADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 113 GMSSVSVQVLI-PLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSR 191
Cdd:PRK11102 90 GLAAAAASVVInALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494855714 192 QPTHKTTYFKLLKSLKQLMIsqpVLRQRSLFqALMFAS-FSL-----FWTSVPVVLAREYGLS 248
Cdd:PRK11102 170 LPKERRQPFHLRTTIRNFAS---LFRHKRVL-GYMLASgFSFagmfsFLTAGPFVYIELNGVS 228
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
220-384 |
3.88e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 220 SLFQALMFASFSLFWTSVPVvLAREYGLSQSEIAL-FALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVIAAVCFLPSLF 298
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLvVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 299 ELPYGIIVLA--LTGVFIDFAVQANMVLGQRAVyalEPQSRARLNAIYMTSIFVGGAVGSLIASPLYEAGGWTGIALVAT 376
Cdd:COG2814 95 APSLWLLLAArfLQGLGAGALFPAALALIADLV---PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
....*...
gi 494855714 377 GMPLISLI 384
Cdd:COG2814 172 VLALLALL 179
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
40-309 |
5.27e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 5.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 40 LAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIGM-SSVS 118
Cdd:cd17371 25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 119 VQVLIPLAAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIA----DHFGWRAVFYFAAgCMVFIAGVIYFAI--PSRQ 192
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLLGA-LPALLVLFIRRFVkePPQW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 193 PTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFAS------FSLFWtsVPVVLAREYGLSQSEIALFALVGAAGAVAA 266
Cdd:cd17371 184 QAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGalggyyGITTW--LPSYLTGERGLSFEGSAGYLVVTILGGFLG 261
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 494855714 267 PIV-GRLADK-GYTHQVSLLAKVIAAVCFLPSLFELPYGIIVLAL 309
Cdd:cd17371 262 YLAgGFLADRiGRRNNFALFALGSAISILLYFFLPLSPTLILILG 306
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
159-387 |
7.26e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 7.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 159 LIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPTHKTTYFKLLKSLKQLMISQPVLRQRSLFQALMFASFSLFWtsvp 238
Cdd:cd17370 148 LYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI---- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 239 vVLAREYGLSQSEIALF-ALVGAAGAVAAPIVGRLADKGYTHQVSLLAKVI-AAVCFLPSLFELPYGIIVL-ALTGVFId 315
Cdd:cd17370 224 -LRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSlALAYLGFALGSSLWLLLLGfILWGLYM- 301
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494855714 316 fAVQANMvlgQRAVYALEPQSRARLNA--IYMTSIFVGGAVGSLIASPLYEAGGWTGIALVATGMPLISLIGYL 387
Cdd:cd17370 302 -GAQESI---ERAAVADLVPAELRGTAygLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-194 |
8.48e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.02 E-value: 8.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 39 LLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVMLILCLMIG----M 114
Cdd:cd17312 28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGlfqsM 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 115 SSVSVQVLIplaAHLSSDEKRGQVLGNIMAGLLLGILLARPISSLIADHFGWRAVFYFAAGCMVFIAGVIYFAIPSRQPT 194
Cdd:cd17312 108 GWPPCVKLL---GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY 184
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
37-140 |
9.04e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 37.93 E-value: 9.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 37 IELLAPEVGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVGTALADSPNVML----ILCLMI 112
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIiariIGGLAV 103
|
90 100
....*....|....*....|....*...
gi 494855714 113 GMSSVSVQVLIplaAHLSSDEKRGQVLG 140
Cdd:cd17359 104 GGASALVPMYI---AEVAPAEIRGRLVS 128
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
19-123 |
9.66e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 37.94 E-value: 9.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494855714 19 IALCCGLIV-ANIYYAQPIIELLAPE--VGLSAHSASLIVSLTQIGYALGLFFLVPLADLIENKRLMLITLAVSFLSLVG 95
Cdd:cd17315 1 VAALGGLLFgYDLGVINGALLYIAKDlgFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110
....*....|....*....|....*....|..
gi 494855714 96 TALADSPNVML----ILCLMIGMSSVSVQVLI 123
Cdd:cd17315 81 SALAPNVWVLIvgrfLLGLGVGLASVLVPLYI 112
|
|
| |
