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Conserved domains on  [gi|494857636|ref|WP_007583736|]
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MULTISPECIES: LysR family transcriptional regulator [Pseudoalteromonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03601 super family cl35211
HTH-type transcriptional regulator HdfR;
1-273 9.69e-68

HTH-type transcriptional regulator HdfR;


The actual alignment was detected with superfamily member PRK03601:

Pssm-ID: 235137 [Multi-domain]  Cd Length: 275  Bit Score: 211.80  E-value: 9.69e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:PRK03601   1 MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGERLLPYAETLMNTWQAAKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DVALAdNMHKQISLAGTPNIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERIC 160
Cdd:PRK03601  81 EVAHT-SQHNELSIGASASLWECMLTPWLGRLYQNQEALQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 161 ElpiIPVSGYDTATNENFFDNQYVYVDWGTTFSLWHARQFTGKTPPYFRTSTGRIALDLILQCGGSAFIPQVLVEghlEK 240
Cdd:PRK03601 160 H---FTLALYTSAPSKKKSELNYIRLEWGADFQQHEAGLIGADEVPILTTSSAELARQLLATLNGCAFLPVHWAK---EK 233

                        250       260       270
                 ....*....|....*....|....*....|...
gi 494857636 241 GELFHVKGVENTSRDVFIAYHRDNEQKELIETL 273
Cdd:PRK03601 234 GGLHTVPDSTTLSRPLYAIWLQNSDKQALIRDL 266
 
Name Accession Description Interval E-value
PRK03601 PRK03601
HTH-type transcriptional regulator HdfR;
1-273 9.69e-68

HTH-type transcriptional regulator HdfR;


Pssm-ID: 235137 [Multi-domain]  Cd Length: 275  Bit Score: 211.80  E-value: 9.69e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:PRK03601   1 MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGERLLPYAETLMNTWQAAKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DVALAdNMHKQISLAGTPNIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERIC 160
Cdd:PRK03601  81 EVAHT-SQHNELSIGASASLWECMLTPWLGRLYQNQEALQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 161 ElpiIPVSGYDTATNENFFDNQYVYVDWGTTFSLWHARQFTGKTPPYFRTSTGRIALDLILQCGGSAFIPQVLVEghlEK 240
Cdd:PRK03601 160 H---FTLALYTSAPSKKKSELNYIRLEWGADFQQHEAGLIGADEVPILTTSSAELARQLLATLNGCAFLPVHWAK---EK 233

                        250       260       270
                 ....*....|....*....|....*....|...
gi 494857636 241 GELFHVKGVENTSRDVFIAYHRDNEQKELIETL 273
Cdd:PRK03601 234 GGLHTVPDSTTLSRPLYAIWLQNSDKQALIRDL 266
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-279 9.33e-44

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 149.63  E-value: 9.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:COG0583    1 MDLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DVA-LADNMHKQISLAGTPNIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERI 159
Cdd:COG0583   81 ELRaLRGGPRGTLRIGAPPSLARYLLPPLLARFRARHPGVRLELREGNSDRLVDALLEGELDLAIRLGPPPDPGLVARPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 160 CELPIIPV--SGYDTATNENFFDNqyvyvdwgttfslwharqftgktppyfrtstGRIALDLILQCGGSAFIPQVLVEGH 237
Cdd:COG0583  161 GEERLVLVasPDHPLARRAPLVNS-------------------------------LEALLAAVAAGLGIALLPRFLAADE 209

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 494857636 238 LEKGELFHVK-GVENTSRDVFIAYHRDNEQKELIETLVNLLSQ 279
Cdd:COG0583  210 LAAGRLVALPlPDPPPPRPLYLVWRRRRHLSPAVRAFLDFLRE 252
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
3-62 1.18e-21

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 85.90  E-value: 1.18e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636    3 IDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGE 62
Cdd:pfam00126   1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
argP TIGR03298
transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive ...
 1-69 1.28e-14

transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive regulator of argK. It is a negative autoregulator in presence of arginine. It competes with DnaA for oriC iteron (13-mer) binding. It activates dnaA and nrd transcription. It has been demonstrated to be part of the pho regulon (). ArgP mutants convey canavanine (an L-arginine structural homolog) sensitivity. [Cellular processes, Toxin production and resistance, DNA metabolism, DNA replication, recombination, and repair, Regulatory functions, DNA interactions]


Pssm-ID: 274509 [Multi-domain]  Cd Length: 292  Bit Score: 72.26  E-value: 1.28e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494857636    1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRnNIQLTAPGERLLPHAQ 69
Cdd:TIGR03298   1 LDYRQLAALAAVVEEGSFERAAAALSVTPSAVSQRIKALEERLGQPLLVRTQ-PCRATEAGQRLLRHAR 68
PBP2_LTTR_substrate cd05466
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the ...
 117-277 6.50e-05

The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.


Pssm-ID: 176102 [Multi-domain]  Cd Length: 197  Bit Score: 42.97  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 117 PGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERICELPII-------PVSGYDTATNENFFDNQYVYVDWG 189
Cdd:cd05466   27 PGVELSLVEGGSSELLEALLEGELDLAIVALPVDDPGLESEPLFEEPLVlvvppdhPLAKRKSVTLADLADEPLILFERG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 190 TTFSLWHARQFT--GKTP-PYFRTSTGRIALDLILQCGGSAFIPQVLVEGHLEKGelFHVKGVENT--SRDVFIAYHRDN 264
Cdd:cd05466  107 SGLRRLLDRAFAeaGFTPnIALEVDSLEAIKALVAAGLGIALLPESAVEELADGG--LVVLPLEDPplSRTIGLVWRKGR 184

                        170
                 ....*....|...
gi 494857636 265 EQKELIETLVNLL 277
Cdd:cd05466  185 YLSPAARAFLELL 197
 
Name Accession Description Interval E-value
PRK03601 PRK03601
HTH-type transcriptional regulator HdfR;
1-273 9.69e-68

HTH-type transcriptional regulator HdfR;


Pssm-ID: 235137 [Multi-domain]  Cd Length: 275  Bit Score: 211.80  E-value: 9.69e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:PRK03601   1 MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGERLLPYAETLMNTWQAAKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DVALAdNMHKQISLAGTPNIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERIC 160
Cdd:PRK03601  81 EVAHT-SQHNELSIGASASLWECMLTPWLGRLYQNQEALQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 161 ElpiIPVSGYDTATNENFFDNQYVYVDWGTTFSLWHARQFTGKTPPYFRTSTGRIALDLILQCGGSAFIPQVLVEghlEK 240
Cdd:PRK03601 160 H---FTLALYTSAPSKKKSELNYIRLEWGADFQQHEAGLIGADEVPILTTSSAELARQLLATLNGCAFLPVHWAK---EK 233

                        250       260       270
                 ....*....|....*....|....*....|...
gi 494857636 241 GELFHVKGVENTSRDVFIAYHRDNEQKELIETL 273
Cdd:PRK03601 234 GGLHTVPDSTTLSRPLYAIWLQNSDKQALIRDL 266
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-279 9.33e-44

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 149.63  E-value: 9.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:COG0583    1 MDLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DVA-LADNMHKQISLAGTPNIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERI 159
Cdd:COG0583   81 ELRaLRGGPRGTLRIGAPPSLARYLLPPLLARFRARHPGVRLELREGNSDRLVDALLEGELDLAIRLGPPPDPGLVARPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 160 CELPIIPV--SGYDTATNENFFDNqyvyvdwgttfslwharqftgktppyfrtstGRIALDLILQCGGSAFIPQVLVEGH 237
Cdd:COG0583  161 GEERLVLVasPDHPLARRAPLVNS-------------------------------LEALLAAVAAGLGIALLPRFLAADE 209

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 494857636 238 LEKGELFHVK-GVENTSRDVFIAYHRDNEQKELIETLVNLLSQ 279
Cdd:COG0583  210 LAAGRLVALPlPDPPPPRPLYLVWRRRRHLSPAVRAFLDFLRE 252
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
3-62 1.18e-21

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 85.90  E-value: 1.18e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636    3 IDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGE 62
Cdd:pfam00126   1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
PRK13348 PRK13348
HTH-type transcriptional regulator ArgP;
2-87 5.67e-17

HTH-type transcriptional regulator ArgP;


Pssm-ID: 237357 [Multi-domain]  Cd Length: 294  Bit Score: 79.24  E-value: 5.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   2 DIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRnNIQLTAPGERLLPHAQMI---------- 71
Cdd:PRK13348   3 DYKQLEALAAVVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVRGR-PCRPTPAGQRLLRHLRQValleadllst 81

                         90
                 ....*....|....*.
gi 494857636  72 ITGMQRAKVDVALADN 87
Cdd:PRK13348  82 LPAERGSPPTLAIAVN 97
PRK11242 PRK11242
DNA-binding transcriptional regulator CynR; Provisional
 9-157 2.30e-16

DNA-binding transcriptional regulator CynR; Provisional


Pssm-ID: 183051 [Multi-domain]  Cd Length: 296  Bit Score: 77.30  E-value: 2.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   9 FVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHA----QMIITGmQRAKVDVal 84
Cdd:PRK11242   9 FLAVAEHGNFTRAAEALHVSQPTLSQQIRQLEESLGVQLFDRSGRTVRLTDAGEVYLRYArralQDLEAG-RRAIHDV-- 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494857636  85 ADNMHKQISLAGTPniwdAFLQFGITNIVSAM----PGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVE 157
Cdd:PRK11242  86 ADLSRGSLRLAMTP----TFTAYLIGPLIDAFharyPGITLTIREMSQERIEALLADDELDVGIAFAPVHSPEIEAQ 158
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
1-76 1.43e-15

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 75.23  E-value: 1.43e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQ 76
Cdd:PRK10094   2 FDPETLRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLE 77
PRK03635 PRK03635
ArgP/LysG family DNA-binding transcriptional regulator;
1-70 1.14e-14

ArgP/LysG family DNA-binding transcriptional regulator;


Pssm-ID: 235144 [Multi-domain]  Cd Length: 294  Bit Score: 72.50  E-value: 1.14e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRnNIQLTAPGERLLPHAQM 70
Cdd:PRK03635   2 LDYKQLEALAAVVREGSFERAAQKLHITQSAVSQRIKALEERVGQVLLVRTQ-PCRPTEAGQRLLRHARQ 70
argP TIGR03298
transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive ...
 1-69 1.28e-14

transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive regulator of argK. It is a negative autoregulator in presence of arginine. It competes with DnaA for oriC iteron (13-mer) binding. It activates dnaA and nrd transcription. It has been demonstrated to be part of the pho regulon (). ArgP mutants convey canavanine (an L-arginine structural homolog) sensitivity. [Cellular processes, Toxin production and resistance, DNA metabolism, DNA replication, recombination, and repair, Regulatory functions, DNA interactions]


Pssm-ID: 274509 [Multi-domain]  Cd Length: 292  Bit Score: 72.26  E-value: 1.28e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494857636    1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRnNIQLTAPGERLLPHAQ 69
Cdd:TIGR03298   1 LDYRQLAALAAVVEEGSFERAAAALSVTPSAVSQRIKALEERLGQPLLVRTQ-PCRATEAGQRLLRHAR 68
PRK15092 PRK15092
DNA-binding transcriptional repressor LrhA; Provisional
 1-144 2.13e-13

DNA-binding transcriptional repressor LrhA; Provisional


Pssm-ID: 237907 [Multi-domain]  Cd Length: 310  Bit Score: 68.90  E-value: 2.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIItgmqRAKv 80
Cdd:PRK15092  11 LDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLLGYARKIL----RFN- 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494857636  81 DVALADNMHKQI----SLAGTPNIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAI 144
Cdd:PRK15092  86 DEACSSLMYSNLqgvlTIGASDDTADTILPFLLNRVSSVYPKLALDVRVKRNAFMMEMLESQEVDLAV 153
PRK09986 PRK09986
LysR family transcriptional regulator;
1-144 1.50e-12

LysR family transcriptional regulator;


Pssm-ID: 182183 [Multi-domain]  Cd Length: 294  Bit Score: 66.28  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMII--TGMQRA 78
Cdd:PRK09986   7 IDLKLLRYFLAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRSVVLTHAGKILMEESRRLLdnAEQSLA 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494857636  79 KVD-VALADNMHKQISLAGTPnIWDAFLQfGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAI 144
Cdd:PRK09986  87 RVEqIGRGEAGRIEIGIVGTA-LWGRLRP-AMRHFLKENPNVEWLLRELSPSMQMAALERRELDAGI 151
PRK10086 PRK10086
DNA-binding transcriptional regulator DsdC;
6-65 3.51e-12

DNA-binding transcriptional regulator DsdC;


Pssm-ID: 182231 [Multi-domain]  Cd Length: 311  Bit Score: 65.41  E-value: 3.51e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   6 LKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLL 65
Cdd:PRK10086  19 LHTFEVAARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRKVELTEEGKRVF 78
PRK09906 PRK09906
DNA-binding transcriptional regulator HcaR; Provisional
 1-165 7.76e-12

DNA-binding transcriptional regulator HcaR; Provisional


Pssm-ID: 182137 [Multi-domain]  Cd Length: 296  Bit Score: 64.41  E-value: 7.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:PRK09906   1 MELRHLRYFVAVAEELNFTKAAEKLHTAQPSLSQQIKDLENCVGVPLLVRDKRKVALTAAGEVFLQDARAILEQAEKAKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DVALADNMHKQISLAGTPNIWDAFLQFGITNIVSAMPG--VSLVAEVKAQQESTrlLLERTLDLAILFDPPKVDELVVER 158
Cdd:PRK09906  81 RARKIVQEDRQLTIGFVPSAEVNLLPKVLPMFRLRHPDtlIELVSLITTQQEEK--LRRGELDVGFMRHPVYSDEIDYLE 158


                 ....*..
gi 494857636 159 ICELPII 165
Cdd:PRK09906 159 LLDEPLV 165
rbcR CHL00180
LysR transcriptional regulator; Provisional
 3-73 1.12e-11

LysR transcriptional regulator; Provisional


Pssm-ID: 177082 [Multi-domain]  Cd Length: 305  Bit Score: 63.89  E-value: 1.12e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494857636   3 IDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIIT 73
Cdd:CHL00180   7 LDQLRILKAIATEGSFKKAAESLYISQPAVSLQIKNLEKQLNIPLFDRSKNKASLTEAGELLLRYGNRILA 77
PRK11074 PRK11074
putative DNA-binding transcriptional regulator; Provisional
 12-115 5.83e-11

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182948 [Multi-domain]  Cd Length: 300  Bit Score: 61.88  E-value: 5.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  12 VVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKVDValadnmhKQ 91
Cdd:PRK11074  13 VARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGEWFVKEARSVIKKMQETRRQC-------QQ 85

                         90       100
                 ....*....|....*....|....
gi 494857636  92 ISlagtpNIWDAFLQFGITNIVSA 115
Cdd:PRK11074  86 VA-----NGWRGQLSIAVDNIVRP 104
PRK11139 PRK11139
DNA-binding transcriptional activator GcvA; Provisional
 16-78 8.12e-11

DNA-binding transcriptional activator GcvA; Provisional


Pssm-ID: 182990 [Multi-domain]  Cd Length: 297  Bit Score: 61.40  E-value: 8.12e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494857636  16 RH--FGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRA 78
Cdd:PRK11139  19 RHlsFTRAAEELFVTQAAVSHQIKALEDFLGLKLFRRRNRSLLLTEEGQRYFLDIREIFDQLAEA 83
PRK09791 PRK09791
LysR family transcriptional regulator;
6-100 1.60e-09

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 57.46  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   6 LKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKVDVala 85
Cdd:PRK09791  10 IRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEELRAAQEDI--- 86

                         90
                 ....*....|....*
gi 494857636  86 dnMHKQISLAGTPNI 100
Cdd:PRK09791  87 --RQRQGQLAGQINI 99
PRK10341 PRK10341
transcriptional regulator TdcA;
6-157 1.64e-09

transcriptional regulator TdcA;


Pssm-ID: 182391 [Multi-domain]  Cd Length: 312  Bit Score: 57.56  E-value: 1.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   6 LKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKVDV-AL 84
Cdd:PRK10341  12 LVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELIVRKNTGVTLTPAGQVLLSRSESITREMKNMVNEInGM 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494857636  85 ADNMHKQISLAGTPNIWDAFLQFGITNIVSAMPGVSlVAEVKAQQeSTRLLLERT--LDLAI--LFDPPKVDELVVE 157
Cdd:PRK10341  92 SSEAVVDVSFGFPSLIGFTFMSDMINKFKEVFPKAQ-VSMYEAQL-SSFLPAIRDgrLDFAIgtLSNEMKLQDLHVE 166
PRK12682 PRK12682
transcriptional regulator CysB-like protein; Reviewed
 1-79 8.48e-09

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 183679 [Multi-domain]  Cd Length: 309  Bit Score: 55.38  E-value: 8.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRtRHFG--KAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQ-LTAPGERLLPHAQMIITGMQR 77
Cdd:PRK12682   1 MNLQQLRFVREAVR-RNLNltEAAKALHTSQPGVSKAIIELEEELGIEIFIRHGKRLKgLTEPGKAVLDVIERILREVGN 79


                 ..
gi 494857636  78 AK 79
Cdd:PRK12682  80 IK 81
LysR_substrate pfam03466
LysR substrate binding domain; The structure of this domain is known and is similar to the ...
 117-277 1.69e-08

LysR substrate binding domain; The structure of this domain is known and is similar to the periplasmic binding proteins. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460931 [Multi-domain]  Cd Length: 205  Bit Score: 53.45  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  117 PGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERICELPIIPV-------SGYDTATNENFFDNQYVYVDWG 189
Cdd:pfam03466  29 PDVELELTEGNSEELLDLLLEGELDLAIRRGPPDDPGLEARPLGEEPLVLVappdhplARGEPVSLEDLADEPLILLPPG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  190 TTFSLWHARQF--TGKTP-PYFRTSTGRIALDLILQCGGSAFIPQVLVEGHLEKGELFHVKGVENT-SRDVFIAYHRDNE 265
Cdd:pfam03466 109 SGLRDLLDRALraAGLRPrVVLEVNSLEALLQLVAAGLGIALLPRSAVARELADGRLVALPLPEPPlPRELYLVWRKGRP 188

                         170
                  ....*....|..
gi 494857636  266 QKELIETLVNLL 277
Cdd:pfam03466 189 LSPAVRAFIEFL 200
PRK12684 PRK12684
CysB family HTH-type transcriptional regulator;
1-79 5.70e-08

CysB family HTH-type transcriptional regulator;


Pssm-ID: 237173 [Multi-domain]  Cd Length: 313  Bit Score: 53.06  E-value: 5.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRtRHFG--KAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQ-LTAPGERLLPHAQMIITGMQR 77
Cdd:PRK12684   1 MNLHQLRFVREAVR-QNFNltEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRLRgLTEPGRIILASVERILQEVEN 79


                 ..
gi 494857636  78 AK 79
Cdd:PRK12684  80 LK 81
PRK12683 PRK12683
transcriptional regulator CysB-like protein; Reviewed
 1-144 9.12e-08

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 237172 [Multi-domain]  Cd Length: 309  Bit Score: 52.35  E-value: 9.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRtRHFG--KAAENLYITQSAVSFRIRQLEQGLGVNLFIRQ-RNNIQLTAPG-------ERLLPHAQM 70
Cdd:PRK12683   1 MNFQQLRIIREAVR-QNFNltEVANALYTSQSGVSKQIKDLEDELGVEIFIRRgKRLTGLTEPGkellqivERMLLDAEN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  71 IitgmQRAKVDVALADNMHKQISLAGT------PNIwdaflqfgITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAI 144
Cdd:PRK12683  80 L----RRLAEQFADRDSGHLTVATTHTqaryalPKV--------VRQFKEVFPKVHLALRQGSPQEIAEMLLNGEADIGI 147
PRK15421 PRK15421
HTH-type transcriptional regulator MetR;
1-78 2.43e-07

HTH-type transcriptional regulator MetR;


Pssm-ID: 185319 [Multi-domain]  Cd Length: 317  Bit Score: 51.17  E-value: 2.43e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRA 78
Cdd:PRK15421   2 IEVKHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQISQA 79
PRK10082 PRK10082
hypochlorite stress DNA-binding transcriptional regulator HypT;
6-117 4.04e-07

hypochlorite stress DNA-binding transcriptional regulator HypT;


Pssm-ID: 182228 [Multi-domain]  Cd Length: 303  Bit Score: 50.44  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   6 LKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGErlLPHAQmIITGMQRAKVDVAL- 84
Cdd:PRK10082  16 LYDFLTLEKCRNFSQAAVSRNVSQPAFSRRIRALEQAIGVELFNRQVTPLQLSEQGK--IFHSQ-IRHLLQQLESNLAEl 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 494857636  85 ---ADNMHKQISLAGTPNiwdafLQFG-ITNIVSAMP 117
Cdd:PRK10082  93 rggSDYAQRKIKIAAAHS-----LSLGlLPSIISQMP 124
PRK11233 PRK11233
nitrogen assimilation transcriptional regulator; Provisional
 1-147 5.46e-07

nitrogen assimilation transcriptional regulator; Provisional


Pssm-ID: 183045 [Multi-domain]  Cd Length: 305  Bit Score: 50.07  E-value: 5.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:PRK11233   1 MNFRRLKYFVKIVDIGSLTQAAEVLHIAQPALSQQVATLEGELNQQLLIRTKRGVTPTEAGKILYTHARAILRQCEQAQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  81 DV-ALADNMHKQISLAGTPNIWDAFLqfgitnivsAMPgvsLVAEVKAQ--------QES-----TRLLLERTLDLAILF 146
Cdd:PRK11233  81 AVhNVGQALSGQVSIGLAPGTAASSL---------TMP---LLQAVRAEfpgivlylHENsgatlNEKLMNGQLDMAVIY 148


                 .
gi 494857636 147 D 147
Cdd:PRK11233 149 E 149
PRK09801 PRK09801
LysR family transcriptional regulator;
6-82 1.20e-06

LysR family transcriptional regulator;


Pssm-ID: 182085 [Multi-domain]  Cd Length: 310  Bit Score: 48.88  E-value: 1.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494857636   6 LKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKVDV 82
Cdd:PRK09801  11 LQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEHALEILTQYQRLVDDV 87
cbl PRK12679
HTH-type transcriptional regulator Cbl;
1-73 1.35e-06

HTH-type transcriptional regulator Cbl;


Pssm-ID: 183676 [Multi-domain]  Cd Length: 316  Bit Score: 49.04  E-value: 1.35e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494857636   1 MDIDLLKTFVEVVRtRHFG--KAAENLYITQSAVSFRIRQLEQGLGVNLFIRQ-RNNIQLTAPGERLLPHAQMIIT 73
Cdd:PRK12679   1 MNFQQLKIIREAAR-QDYNltEVANMLFTSQSGVSRHIRELEDELGIEIFIRRgKRLLGMTEPGKALLVIAERILN 75
PRK11716 PRK11716
HTH-type transcriptional activator IlvY;
26-100 1.86e-05

HTH-type transcriptional activator IlvY;


Pssm-ID: 236961 [Multi-domain]  Cd Length: 269  Bit Score: 45.19  E-value: 1.86e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494857636  26 YITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKVDValadnMHKQISLAGTPNI 100
Cdd:PRK11716   2 HVSPSTLSRQIQRLEEELGQPLFVRDNRSVTLTEAGEELRPFAQQTLLQWQQLRHTL-----DQQGPSLSGELSL 71
PBP2_LTTR_substrate cd05466
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the ...
 117-277 6.50e-05

The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.


Pssm-ID: 176102 [Multi-domain]  Cd Length: 197  Bit Score: 42.97  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 117 PGVSLVAEVKAQQESTRLLLERTLDLAILFDPPKVDELVVERICELPII-------PVSGYDTATNENFFDNQYVYVDWG 189
Cdd:cd05466   27 PGVELSLVEGGSSELLEALLEGELDLAIVALPVDDPGLESEPLFEEPLVlvvppdhPLAKRKSVTLADLADEPLILFERG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636 190 TTFSLWHARQFT--GKTP-PYFRTSTGRIALDLILQCGGSAFIPQVLVEGHLEKGelFHVKGVENT--SRDVFIAYHRDN 264
Cdd:cd05466  107 SGLRRLLDRAFAeaGFTPnIALEVDSLEAIKALVAAGLGIALLPESAVEELADGG--LVVLPLEDPplSRTIGLVWRKGR 184

                        170
                 ....*....|...
gi 494857636 265 EQKELIETLVNLL 277
Cdd:cd05466  185 YLSPAARAFLELL 197
PRK10837 PRK10837
putative DNA-binding transcriptional regulator; Provisional
 1-68 1.01e-04

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182768 [Multi-domain]  Cd Length: 290  Bit Score: 43.14  E-value: 1.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDL--LKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHA 68
Cdd:PRK10837   1 MHITLrqLEVFAEVLKSGSTTQASVMLALSQSAVSAALTDLEGQLGVQLFDRVGKRLVVNEHGRLLYPRA 70
PRK11151 PRK11151
DNA-binding transcriptional regulator OxyR; Provisional
 1-72 1.13e-04

DNA-binding transcriptional regulator OxyR; Provisional


Pssm-ID: 182999 [Multi-domain]  Cd Length: 305  Bit Score: 43.09  E-value: 1.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMII 72
Cdd:PRK11151   1 MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVL 72
PRK14997 PRK14997
LysR family transcriptional regulator; Provisional
 1-83 1.16e-04

LysR family transcriptional regulator; Provisional


Pssm-ID: 184959 [Multi-domain]  Cd Length: 301  Bit Score: 43.06  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAKV 80
Cdd:PRK14997   2 TDLNDFAWFVHVVEEGGFAAAGRALDEPKSKLSRRIAQLEERLGVRLIQRTTRQFNVTEVGQTFYEHCKAMLVEAQAAQD 81


                 ...
gi 494857636  81 DVA 83
Cdd:PRK14997  82 AIA 84
cysB PRK12681
HTH-type transcriptional regulator CysB;
1-79 4.84e-04

HTH-type transcriptional regulator CysB;


Pssm-ID: 183678 [Multi-domain]  Cd Length: 324  Bit Score: 41.04  E-value: 4.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   1 MDIDLLKTFVEVVRTR-HFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNI-QLTAPGERLLPHAQMIITGMQRA 78
Cdd:PRK12681   1 MKLQQLRYIVEVVNHNlNVSATAEGLYTSQPGISKQVRMLEDELGIQIFARSGKHLtQVTPAGEEIIRIAREILSKVESI 80


                 .
gi 494857636  79 K 79
Cdd:PRK12681  81 K 81
PRK12680 PRK12680
LysR family transcriptional regulator;
21-145 6.37e-04

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 40.76  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  21 AAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQ-LTAPGERLLPHAQMIITGMQRAKVDVALADNMHK-QISLAGTP 98
Cdd:PRK12680  22 AAARVHATQPGLSKQLKQLEDELGFLLFVRKGRSLEsVTPAGVEVIERARAVLSEANNIRTYAANQRRESQgQLTLTTTH 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 494857636  99 NIWDAFLQFGITNIVSAMPGVSLVAEVKAQQESTRLLLERTLDLAIL 145
Cdd:PRK12680 102 TQARFVLPPAVAQIKQAYPQVSVHLQQAAESAALDLLGQGDADIAIV 148
PRK11013 PRK11013
DNA-binding transcriptional regulator LysR; Provisional
 9-140 1.18e-03

DNA-binding transcriptional regulator LysR; Provisional


Pssm-ID: 236819 [Multi-domain]  Cd Length: 309  Bit Score: 39.98  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636   9 FVEVVRTRHFGKAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHAQMIITGMQRAkvdVALADNM 88
Cdd:PRK11013  12 FHAVMTAGSLTEAARLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSYYGLDRI---VSAAESL 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 494857636  89 ----HKQISLAGTPNIWDAFLQFGITNIVSAMPGVSLVAevkAQQESTrlLLERTL 140
Cdd:PRK11013  89 refrQGQLSIACLPVFSQSLLPGLCQPFLARYPDVSLNI---VPQESP--LLEEWL 139
nhaR PRK11062
transcriptional activator NhaR; Provisional
 20-92 7.27e-03

transcriptional activator NhaR; Provisional


Pssm-ID: 182938 [Multi-domain]  Cd Length: 296  Bit Score: 37.30  E-value: 7.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494857636  20 KAAENLYITQSAVSFRIRQLEQGLGVNLFIRQRNNIQLTAPGERLLPHA--------QM--IITGMQRAKV--DVALADN 87
Cdd:PRK11062  23 GAAEALFLTPQTITGQIKALEERLQGKLFKRKGRGLEPTELGELVFRYAdkmftlsqEMldIVNYRKESNLlfDVGVADA 102


                 ....*
gi 494857636  88 MHKQI 92
Cdd:PRK11062 103 LSKRL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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