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Conserved domains on  [gi|494884863|ref|WP_007610911|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-143 1.60e-31

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 110.06  E-value: 1.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863   7 NEEEVMRSMNLYKVFARAFKSVSEHSIRDSKEHGFNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGF 86
Cdd:COG1846    2 SDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 494884863  87 LVREQDPKDKRSVYAHLTDKGNEYLDKIYPIHSLRIARAFSGLMPEEQEQLIALLKK 143
Cdd:COG1846   82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRR 138
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-143 1.60e-31

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 110.06  E-value: 1.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863   7 NEEEVMRSMNLYKVFARAFKSVSEHSIRDSKEHGFNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGF 86
Cdd:COG1846    2 SDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 494884863  87 LVREQDPKDKRSVYAHLTDKGNEYLDKIYPIHSLRIARAFSGLMPEEQEQLIALLKK 143
Cdd:COG1846   82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRR 138
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
34-134 5.68e-30

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 104.60  E-value: 5.68e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863    34 RDSKEHGFNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAHLTDKGNEYLDK 113
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 494884863   114 IYPIHSLRIARAFSGLMPEEQ 134
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 2.27e-17

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 71.04  E-value: 2.27e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 494884863   41 FNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSV 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 37-143 3.48e-10

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 55.52  E-value: 3.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863  37 KEHGFNPTEFAVLELLYTRGPQKLQ--QIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAHLTDKGNEYLDKI 114
Cdd:PRK10870  49 KAQGINETLFMALITLESQENHSIQpsELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREV 128

                         90       100
                 ....*....|....*....|....*....
gi 494884863 115 YPIHSLRIARAFSGLMPEEQEQLIALLKK 143
Cdd:PRK10870 129 LPPQHNCLHQLWSALSTTEKDQLEQITRK 157
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-143 1.60e-31

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 110.06  E-value: 1.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863   7 NEEEVMRSMNLYKVFARAFKSVSEHSIRDSKEHGFNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGF 86
Cdd:COG1846    2 SDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 494884863  87 LVREQDPKDKRSVYAHLTDKGNEYLDKIYPIHSLRIARAFSGLMPEEQEQLIALLKK 143
Cdd:COG1846   82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRR 138
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
34-134 5.68e-30

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 104.60  E-value: 5.68e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863    34 RDSKEHGFNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAHLTDKGNEYLDK 113
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 494884863   114 IYPIHSLRIARAFSGLMPEEQ 134
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 2.27e-17

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 71.04  E-value: 2.27e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 494884863   41 FNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSV 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 37-143 3.48e-10

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 55.52  E-value: 3.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863  37 KEHGFNPTEFAVLELLYTRGPQKLQ--QIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAHLTDKGNEYLDKI 114
Cdd:PRK10870  49 KAQGINETLFMALITLESQENHSIQpsELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREV 128

                         90       100
                 ....*....|....*....|....*....
gi 494884863 115 YPIHSLRIARAFSGLMPEEQEQLIALLKK 143
Cdd:PRK10870 129 LPPQHNCLHQLWSALSTTEKDQLEQITRK 157
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 39-98 4.25e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 52.59  E-value: 4.25e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884863   39 HGFNPTEFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRS 98
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
41-107 1.54e-09

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 51.14  E-value: 1.54e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494884863   41 FNPTEFAVLELLYTRG-PQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAHLTDKG 107
Cdd:pfam13463   1 LTRLEALILHNIGHRGdPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
78-120 4.11e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 34.46  E-value: 4.11e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 494884863  78 IDKLERNGFLvrEQDPKDKRSVYaHLTDKGNEYLDKIYPIHSL 120
Cdd:COG3432   42 LDLLEEKGLI--EKEDDGGRRIY-RITEKGREFLEKYEEIKEL 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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