|
Name |
Accession |
Description |
Interval |
E-value |
| mtnA |
PRK05720 |
methylthioribose-1-phosphate isomerase; Reviewed |
7-349 |
0e+00 |
|
methylthioribose-1-phosphate isomerase; Reviewed
Pssm-ID: 235578 Cd Length: 344 Bit Score: 565.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK05720 2 QPRPVAWKDGAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDGEEFLKKLEEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 87 KAYLNSSRPTAVNLAWALDRLTDSIRdAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK05720 82 AAYLAASRPTAVNLFWALDRMREVLA-PLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRKGQGILTHCNAGWLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK05720 161 TAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKIDAVIVGADRIAANG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 DTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK05720 241 DVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADGKEIPIEERDPEEVTEVGGVRIAPEGVKVYNPAFDVTPAELIT 320
|
330 340
....*....|....*....|...
gi 494884896 327 GIITEKGIVTGSYTEEIEQLFAD 349
Cdd:PRK05720 321 GIITEKGIVAPPDTANLAALFPE 343
|
|
| MtnA |
COG0182 |
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ... |
8-348 |
0e+00 |
|
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];
Pssm-ID: 439952 Cd Length: 343 Bit Score: 557.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 8 PRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVK 87
Cdd:COG0182 3 VRTIWWDGGALVLLDQTLLPHEEEYVELTTVEDVAEAIRDMVVRGAPAIGVAAAYGVALAAREAAADDREEFLAELEEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 88 AYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIAT 167
Cdd:COG0182 83 EYLAATRPTAVNLFWALDRMLAALEELPSVEEIREALLAEALAIADEDVAANRAIGEHGAELIPDGDTILTHCNAGALAT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 168 SRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGD 247
Cdd:COG0182 163 VGYGTALGVIRAAHEAGKLIHVYADETRPLLQGARLTAWELMQDGIPVTLITDNAAGHLMQRGKVDAVIVGADRIAANGD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 248 TANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISG 327
Cdd:COG0182 243 VANKIGTYGLAVLAKHHGIPFYVAAPTSTIDLSLPDGEDIPIEERDPDEVTHVGGRRIAPEGVPVYNPAFDVTPAELITA 322
|
330 340
....*....|....*....|.
gi 494884896 328 IITEKGIVTGSYTEEIEQLFA 348
Cdd:COG0182 323 IITEKGVIRPPYEENLAKLFP 343
|
|
| salvage_mtnA |
TIGR00512 |
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ... |
9-337 |
0e+00 |
|
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 513.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKA 88
Cdd:TIGR00512 1 RAIKWSRGSLEILDQRLLPHESEYIEVTTVEDVADAIRDMRVRGAPAIGIVAAYGLALAAREGETDEGEEFKAFLEEKLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 89 YLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQ------IMTICNA 162
Cdd:TIGR00512 81 YLVSSRPTAVNLSWALDRMRAALREAKTVADIKEALLAEAERILEEDLEDNRAIGENGAALIKKGVAakepvrVLTHCNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 163 GSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRI 242
Cdd:TIGR00512 161 GSLATAGYGTALGVIRSAHEKGRLEHVYADETRPYNQGARLTAWELVQEGIPATLITDSMAAHLMKHGEVDAVIVGADRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 243 AKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPG 322
Cdd:TIGR00512 241 AANGDTANKIGTYQLAILAKHHGVPFYVAAPTSTIDLELADGAEIPIEERPPEEVTHVGGVRIAPPGIGVWNPAFDVTPA 320
|
330
....*....|....*
gi 494884896 323 SLISGIITEKGIVTG 337
Cdd:TIGR00512 321 ELITGIITEKGVITP 335
|
|
| IF-2B |
pfam01008 |
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ... |
49-336 |
8.35e-112 |
|
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Pssm-ID: 395798 [Multi-domain] Cd Length: 281 Bit Score: 326.94 E-value: 8.35e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 49 KVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIR---DAISINEAKTTLV 125
Cdd:pfam01008 1 KVRGSPAIAIAALEGLLLVIQDARTPTVAELKEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLalhSSSDVEEAKESLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 126 HEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGsiatsrygTALAPFYLAKQKDLGLHIYACETRPVLQGsRLTA 205
Cdd:pfam01008 81 EAADEFIDEIEEARRKIGAIAAELIKDGDTILTHCNSG--------TVLGVLRAAHKEGKRFRVIVTESRPRLQG-RLTA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 206 WELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGD 285
Cdd:pfam01008 152 KELVQAGIPVTLITDSAVGYVMQE--VDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDE 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 494884896 286 QIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVT 336
Cdd:pfam01008 230 DIFIEERDPEEVLYRTGVRIAPPNLKVRNPAFDYTPPELITLIITEVGVLP 280
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| mtnA |
PRK05720 |
methylthioribose-1-phosphate isomerase; Reviewed |
7-349 |
0e+00 |
|
methylthioribose-1-phosphate isomerase; Reviewed
Pssm-ID: 235578 Cd Length: 344 Bit Score: 565.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK05720 2 QPRPVAWKDGAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDGEEFLKKLEEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 87 KAYLNSSRPTAVNLAWALDRLTDSIRdAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK05720 82 AAYLAASRPTAVNLFWALDRMREVLA-PLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRKGQGILTHCNAGWLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK05720 161 TAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKIDAVIVGADRIAANG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 DTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK05720 241 DVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADGKEIPIEERDPEEVTEVGGVRIAPEGVKVYNPAFDVTPAELIT 320
|
330 340
....*....|....*....|...
gi 494884896 327 GIITEKGIVTGSYTEEIEQLFAD 349
Cdd:PRK05720 321 GIITEKGIVAPPDTANLAALFPE 343
|
|
| MtnA |
COG0182 |
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ... |
8-348 |
0e+00 |
|
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];
Pssm-ID: 439952 Cd Length: 343 Bit Score: 557.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 8 PRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVK 87
Cdd:COG0182 3 VRTIWWDGGALVLLDQTLLPHEEEYVELTTVEDVAEAIRDMVVRGAPAIGVAAAYGVALAAREAAADDREEFLAELEEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 88 AYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIAT 167
Cdd:COG0182 83 EYLAATRPTAVNLFWALDRMLAALEELPSVEEIREALLAEALAIADEDVAANRAIGEHGAELIPDGDTILTHCNAGALAT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 168 SRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGD 247
Cdd:COG0182 163 VGYGTALGVIRAAHEAGKLIHVYADETRPLLQGARLTAWELMQDGIPVTLITDNAAGHLMQRGKVDAVIVGADRIAANGD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 248 TANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISG 327
Cdd:COG0182 243 VANKIGTYGLAVLAKHHGIPFYVAAPTSTIDLSLPDGEDIPIEERDPDEVTHVGGRRIAPEGVPVYNPAFDVTPAELITA 322
|
330 340
....*....|....*....|.
gi 494884896 328 IITEKGIVTGSYTEEIEQLFA 348
Cdd:COG0182 323 IITEKGVIRPPYEENLAKLFP 343
|
|
| salvage_mtnA |
TIGR00512 |
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ... |
9-337 |
0e+00 |
|
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 513.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKA 88
Cdd:TIGR00512 1 RAIKWSRGSLEILDQRLLPHESEYIEVTTVEDVADAIRDMRVRGAPAIGIVAAYGLALAAREGETDEGEEFKAFLEEKLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 89 YLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQ------IMTICNA 162
Cdd:TIGR00512 81 YLVSSRPTAVNLSWALDRMRAALREAKTVADIKEALLAEAERILEEDLEDNRAIGENGAALIKKGVAakepvrVLTHCNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 163 GSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRI 242
Cdd:TIGR00512 161 GSLATAGYGTALGVIRSAHEKGRLEHVYADETRPYNQGARLTAWELVQEGIPATLITDSMAAHLMKHGEVDAVIVGADRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 243 AKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPG 322
Cdd:TIGR00512 241 AANGDTANKIGTYQLAILAKHHGVPFYVAAPTSTIDLELADGAEIPIEERPPEEVTHVGGVRIAPPGIGVWNPAFDVTPA 320
|
330
....*....|....*
gi 494884896 323 SLISGIITEKGIVTG 337
Cdd:TIGR00512 321 ELITGIITEKGVITP 335
|
|
| eIF-2B_rel |
TIGR00524 |
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes ... |
35-337 |
4.22e-165 |
|
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins. [Unknown function, General]
Pssm-ID: 273119 [Multi-domain] Cd Length: 303 Bit Score: 462.68 E-value: 4.22e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 35 LETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIRDA 114
Cdd:TIGR00524 1 CRTYEDVAEAIKSMVVRGAPAIGVAAAYGLALAALKISHVNVEEFKEDLEKAADFLLSTRPTAVNLFWALDRVLNSLKSG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 115 ISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIATSRYGTALAPFYLAKQKDLGLHIYACET 194
Cdd:TIGR00524 81 ESVEEFKESLLREAIEIINEDLETNRKIGENGAKLIKDGDTVLTHCNAGALATSGYGTALGVIRSAWEDGKRIRVIADET 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 195 RPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPL 274
Cdd:TIGR00524 161 RPRNQGSRLTAWELVQDGIPVTLITDSAAAYFMQTGEIDAVIVGADRIARNGDVANKIGTYQLAVLAKEFRIPFFVAAPL 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494884896 275 STFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVTG 337
Cdd:TIGR00524 241 STFDPKTSTGEDIIIEERDPEEVAQVGGVRIAPLGVKVYNPAFDITPHDLIDAIITEKGIITP 303
|
|
| PRK06036 |
PRK06036 |
S-methyl-5-thioribose-1-phosphate isomerase; |
9-335 |
3.45e-120 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 180362 Cd Length: 339 Bit Score: 350.18 E-value: 3.45e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 9 RSVEWKETY--IRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK06036 2 RTIDWNDESnsVKLIDQTLLPEEYKVIECKTLESLCEAIKSLRVRGAPALGAAGGYGIALAARLSKAKDVDELLKDLKVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 87 KAYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK06036 82 AETLKSTRPTAVNLSWGVDRVLKAALDAEDVEEIRDIALREAERIAEEDVARNKLIGKHGAKLLEDGDTVLTHCNAGRLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK06036 162 CVDWGTALGVIRSAVEQGKEIKVIACETRPLNQGSRLTTWELMQDNIPVTLITDSMAGIVMRQGMVDKVIVGADRITRDA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 dTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDqIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK06036 242 -VFNKIGTYTHSVLAKEHEIPFYVAAPLSTFDFEGWEGS-VKIEERDPDELRYCGKTQIAPKDVPVYNPAFDATPMENVT 319
|
....*....
gi 494884896 327 GIITEKGIV 335
Cdd:PRK06036 320 AIITEKGVF 328
|
|
| IF-2B |
pfam01008 |
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ... |
49-336 |
8.35e-112 |
|
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Pssm-ID: 395798 [Multi-domain] Cd Length: 281 Bit Score: 326.94 E-value: 8.35e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 49 KVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIR---DAISINEAKTTLV 125
Cdd:pfam01008 1 KVRGSPAIAIAALEGLLLVIQDARTPTVAELKEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLalhSSSDVEEAKESLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 126 HEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGsiatsrygTALAPFYLAKQKDLGLHIYACETRPVLQGsRLTA 205
Cdd:pfam01008 81 EAADEFIDEIEEARRKIGAIAAELIKDGDTILTHCNSG--------TVLGVLRAAHKEGKRFRVIVTESRPRLQG-RLTA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 206 WELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGD 285
Cdd:pfam01008 152 KELVQAGIPVTLITDSAVGYVMQE--VDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDE 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 494884896 286 QIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVT 336
Cdd:pfam01008 230 DIFIEERDPEEVLYRTGVRIAPPNLKVRNPAFDYTPPELITLIITEVGVLP 280
|
|
| PRK05772 |
PRK05772 |
S-methyl-5-thioribose-1-phosphate isomerase; |
9-346 |
1.07e-111 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 168237 Cd Length: 363 Bit Score: 329.41 E-value: 1.07e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKA 88
Cdd:PRK05772 17 LPIIWKDNTLTLLDQSLLPFETVYVDLKTVEEVALAIRNMQVRGAPAIGITAGYGMVLALIENNVKTLDDAIRELTRAKT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 89 YLNSSRPTAVNLAWALDRLTDSIRDAI------SINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNA 162
Cdd:PRK05772 97 ILDSARPTAVNLVWATSRMLNKAKNTVesgnakSVNELIELLKVEAKKIFEEEYDAEIQMGLYGLEKLNDGDTVLTQCNA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 163 GSIAT-SRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADR 241
Cdd:PRK05772 177 GGLATgTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTAVGLVMYKDMVNNVMVGADR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 242 IAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLqIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITP 321
Cdd:PRK05772 257 ILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSTFDL-KSDVNDVKIEERDPNEVRTIRGVPITPEDVNVYNPVFDVTP 335
|
330 340
....*....|....*....|....*
gi 494884896 322 GSLISGIITEKGIVTGSYTEEIEQL 346
Cdd:PRK05772 336 PKYITGIITEKGIIYPPFHKNIRKI 360
|
|
| PRK08334 |
PRK08334 |
S-methyl-5-thioribose-1-phosphate isomerase; |
7-347 |
1.56e-107 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 169386 Cd Length: 356 Bit Score: 318.83 E-value: 1.56e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK08334 13 LPRSVEYEEGKVYMIDQRLLPREFKVIELRTVEEVAEAIKTMTVRGAPAIGAAAAFGLALYAETSKAKTKDEFMDGFYKA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 87 KAYLNSSRPTAVNLAWALDRLTDSIRDAI--SINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDqIMTICNAGS 164
Cdd:PRK08334 93 YETLKNTRPTAVNLFWALNRIKKLVEEHLedPLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPEGN-VLTHCNAGS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 165 IATSRYGTALAPF-YLAKQKDLGLhIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIA 243
Cdd:PRK08334 172 LATVHLGTVGAVLrVMHKDGTLKL-LWVDETRPVLQGARLSAWEYHYDGIPLKLISDNMAGFVMQQGKVDAIIVGADRIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 244 KNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPeDVPVFNPAFDITPGS 323
Cdd:PRK08334 251 ANGDFANKIGTYTLAVLAKEHGIPFFTVAPLSTIDMSLKSGKEIPIEERSPEEVLTCGGCRIAP-DVDVYNPAFDVTPHK 329
|
330 340
....*....|....*....|....
gi 494884896 324 LISGIITEKGIVTGSYTEEIEQLF 347
Cdd:PRK08334 330 YLTGIITDRGVVWPPFERNLKKLF 353
|
|
| PRK06371 |
PRK06371 |
S-methyl-5-thioribose-1-phosphate isomerase; |
9-346 |
1.09e-99 |
|
S-methyl-5-thioribose-1-phosphate isomerase;
Pssm-ID: 180547 Cd Length: 329 Bit Score: 297.97 E-value: 1.09e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDlsdfrrqfaDVKA 88
Cdd:PRK06371 13 KAVWYEDGEVKLIDQRKLPDKIEIFEAKNSDDVAYAIKNMVVRGAPAIGVTAAYGLAMASKNGENMD---------EAVE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 89 YLNSSRPTAVNLAWALDRLtdsirdaiSINEAKttlVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIATS 168
Cdd:PRK06371 84 KIRSTRPTAYDLFKAIRYM--------NSNEFD---MNAARRYAMEIIGRSKKIGEYGNELIKNGARILTHCNAGALAVV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 169 RYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGDT 248
Cdd:PRK06371 153 DWGTALAPIRIAHRNGKNIFVFVDETRPRLQGARLTAWELAQEGIDHAIIADNAAGYFMRKKEIDLVIVGADRIASNGDF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 249 ANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGI 328
Cdd:PRK06371 233 ANKIGTYEKAVLAKVNGIPFYVAAPGSTFDFSIKSGDEIPIEERDENEVLEINGCRIGPQESHARNPAFDVTPNEYVTGF 312
|
330
....*....|....*...
gi 494884896 329 ITEKGIVTgsyTEEIEQL 346
Cdd:PRK06371 313 ITEYGIFK---PNELWKL 327
|
|
| GCD2 |
COG1184 |
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ... |
43-334 |
1.83e-64 |
|
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family is part of the Pathway/BioSystem: Translation factors
Pssm-ID: 440797 [Multi-domain] Cd Length: 304 Bit Score: 206.62 E-value: 1.83e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 43 DAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKT 122
Cdd:COG1184 9 EEIREMEIHGAARIARAAAEALRDLAERSRAADPEEFRRELEAAARALRRARPSAASLPNAVRRVLARVADGETVEEARE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 123 TLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGsiatsrygTALAPFYLAKQKDLGLHIYACETRPVLQGsR 202
Cdd:COG1184 89 AVLEAADEFIERAEEAKERAAEIAAKRIRDGDTILTHSNSS--------TVLAAIEAAVPQGKDIRVYVTESRPRYQG-R 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 203 LTAWELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAplSTFDLQIE 282
Cdd:COG1184 160 ITARELAEAGVPVTLIVDSAARHFLKE--VDRVVVGADTITADGAVVNKIGTSPLALAAREAGVPVTVAA--ETYKFSPE 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 494884896 283 NGDQIPIEERDPDEVrqisgIRTAPEDVPVFNPAFDITPGSLISGIITEKGI 334
Cdd:COG1184 236 TFELVEIEERDPSEV-----YDEEPEGVTVRNPAFDVTPPDLIDAIITERGV 282
|
|
| PRK08535 |
PRK08535 |
ribose 1,5-bisphosphate isomerase; |
39-335 |
2.50e-58 |
|
ribose 1,5-bisphosphate isomerase;
Pssm-ID: 236282 [Multi-domain] Cd Length: 310 Bit Score: 190.88 E-value: 2.50e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 39 EDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALdRLTDSIRDAISIN 118
Cdd:PRK08535 8 LETAEKIKTMEIRGAGRIARAAAEALKDQAEKSDAESPEEFKAEMRAAANILISTRPTAVSLPNAV-RYVMRYYSGETVE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 119 EAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAgSIATSRYGTALapfylakqkDLGLHI--YACETRP 196
Cdd:PRK08535 87 EARESVIERAEEFIESSENAVEKIGEIGAKRIRDGDVIMTHCNS-SAALSVIKTAH---------EQGKDIevIATETRP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 197 VLQGsRLTAWELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAplST 276
Cdd:PRK08535 157 RNQG-HITAKELAEYGIPVTLIVDSAVRYFMKD--VDKVVVGADAITANGAVINKIGTSQIALAAHEARVPFMVAA--ET 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494884896 277 FDLQIEN--GDQIPIEERDPDEVRQISGIRTAPEdVPVFNPAFDITPGSLISGIITEKGIV 335
Cdd:PRK08535 232 YKFSPKTllGELVEIEERDPTEVLPEEILAKLPG-VKVRNPAFDVTPPEYIDAIITEIGAI 291
|
|
| ribulose_e2b2 |
TIGR00511 |
ribose-1,5-bisphosphate isomerase, e2b2 family; The delineation of this family was based ... |
35-335 |
5.02e-51 |
|
ribose-1,5-bisphosphate isomerase, e2b2 family; The delineation of this family was based originally, in part, on a discussion and neighbor-joining phylogenetic study by Kyrpides and Woese of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. Recently, Sato, et al. assigned the function ribulose-1,5 bisphosphate isomerase. [Energy metabolism, Other]
Pssm-ID: 188057 Cd Length: 301 Bit Score: 171.83 E-value: 5.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 35 LETKEDvfdaIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALdRLTDSIRDA 114
Cdd:TIGR00511 3 LETAEK----IRTMEIRGAGRIARAAAAALREQAEKSDAASPEEFRAEMRAAANILISTRPTAVSLPNAL-RYVLKYMSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 115 ISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAgSIATSRYGTALapfylakqkDLGLHI--YAC 192
Cdd:TIGR00511 78 ADVETLRQSVIERADEFINRSEKAQERIGEIGAKRIRDGDVIMTHCNS-EAALSVIKTAF---------EQGKDIevIVT 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 193 ETRPVLQGsRLTAWELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAA 272
Cdd:TIGR00511 148 ETRPRNQG-HITAKELRDYGIPVTLIVDSAARYYMKE--VDHVVVGADAITANGAVINKIGTSQLALAAREARVPFMVAA 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494884896 273 PLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPeDVPVFNPAFDITPGSLISGIITEKGIV 335
Cdd:TIGR00511 225 ETYKFHPKTITGELVEIEERDPTEVLDEEDLKQLG-NVKVRNPAFDVTPPEYVDAIITERGQI 286
|
|
| PRK06372 |
PRK06372 |
translation initiation factor IF-2B subunit delta; Provisional |
111-338 |
1.70e-19 |
|
translation initiation factor IF-2B subunit delta; Provisional
Pssm-ID: 235788 [Multi-domain] Cd Length: 253 Bit Score: 86.50 E-value: 1.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 111 IRDAISINEAKTTLVHEAIQIQIEDEEtcRMIGQNALHLFkkgdqimticNAGSIATSRYGTALAPFYLAKQKDLglHIY 190
Cdd:PRK06372 48 VRNVCDSIISGPNLRPKNLKLGIEKHE--KMAIEHAKPLF----------NDSVIGTISSSQVLKAFISSSEKIK--SVY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 191 ACETRPVLQGSRLtAWELMQGGIDVTLITDsmAAHTMKEKHISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFV 270
Cdd:PRK06372 114 ILESRPMLEGIDM-AKLLVKSGIDVVLLTD--ASMCEAVLNVDAVIVGSDSVLYDGGLIHKNGTFPLALCARYLKKPFYS 190
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494884896 271 AaplsTFDLQIENGdqipIEERDPDEVRQISGIRTApEDVPVFNPAFDITPGSLISGIITEKGIVTGS 338
Cdd:PRK06372 191 L----TISMKIERN----FLYSTYPNFKNHPCSEWN-IDIPCINRYFDKTPPDLIDYYINENGFVKPS 249
|
|
| PRK08335 |
PRK08335 |
translation initiation factor IF-2B subunit alpha; Validated |
136-335 |
2.09e-18 |
|
translation initiation factor IF-2B subunit alpha; Validated
Pssm-ID: 169387 Cd Length: 275 Bit Score: 84.06 E-value: 2.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 136 EETCRMIGQNALHLFKKGDQIMTicnagsiaTSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLtAWELMQGGIDV 215
Cdd:PRK08335 93 EEAKREIGNIGSELIDDGDVIIT--------HSFSSAVLEILKTAKRKGKRFKVILTESAPDYEGLAL-ANELEFLGIEF 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 216 TLITDSMAAHTMKEKHISavIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDqIPIEERdpD 295
Cdd:PRK08335 164 EVITDAQLGLFAKEATLA--LVGADNVTRDGYVVNKAGTYLLALACHDNGVPFYVAAETFKFHPELKSEE-VELVER--P 238
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 494884896 296 EVRQISGIRtapedvpvfNPAFDITPGSLISGIITEKGIV 335
Cdd:PRK08335 239 YARQGHRVR---------NVLFDVTPWKYVRGIITELGIL 269
|
|
|