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Conserved domains on  [gi|494884896|ref|WP_007610944|]
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MULTISPECIES: S-methyl-5-thioribose-1-phosphate isomerase [Bacillus]

Protein Classification

S-methyl-5-thioribose-1-phosphate isomerase( domain architecture ID 10012538)

S-methyl-5-thioribose-1-phosphate isomerase catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methylthioribulose-1-phosphate (MTRu-1-P)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
mtnA PRK05720
methylthioribose-1-phosphate isomerase; Reviewed
7-349 0e+00

methylthioribose-1-phosphate isomerase; Reviewed


:

Pssm-ID: 235578  Cd Length: 344  Bit Score: 565.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK05720   2 QPRPVAWKDGAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDGEEFLKKLEEA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  87 KAYLNSSRPTAVNLAWALDRLTDSIRdAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK05720  82 AAYLAASRPTAVNLFWALDRMREVLA-PLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRKGQGILTHCNAGWLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK05720 161 TAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKIDAVIVGADRIAANG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 DTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK05720 241 DVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADGKEIPIEERDPEEVTEVGGVRIAPEGVKVYNPAFDVTPAELIT 320
                        330       340
                 ....*....|....*....|...
gi 494884896 327 GIITEKGIVTGSYTEEIEQLFAD 349
Cdd:PRK05720 321 GIITEKGIVAPPDTANLAALFPE 343
 
Name Accession Description Interval E-value
mtnA PRK05720
methylthioribose-1-phosphate isomerase; Reviewed
7-349 0e+00

methylthioribose-1-phosphate isomerase; Reviewed


Pssm-ID: 235578  Cd Length: 344  Bit Score: 565.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK05720   2 QPRPVAWKDGAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDGEEFLKKLEEA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  87 KAYLNSSRPTAVNLAWALDRLTDSIRdAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK05720  82 AAYLAASRPTAVNLFWALDRMREVLA-PLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRKGQGILTHCNAGWLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK05720 161 TAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKIDAVIVGADRIAANG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 DTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK05720 241 DVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADGKEIPIEERDPEEVTEVGGVRIAPEGVKVYNPAFDVTPAELIT 320
                        330       340
                 ....*....|....*....|...
gi 494884896 327 GIITEKGIVTGSYTEEIEQLFAD 349
Cdd:PRK05720 321 GIITEKGIVAPPDTANLAALFPE 343
MtnA COG0182
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ...
8-348 0e+00

5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];


Pssm-ID: 439952  Cd Length: 343  Bit Score: 557.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   8 PRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVK 87
Cdd:COG0182    3 VRTIWWDGGALVLLDQTLLPHEEEYVELTTVEDVAEAIRDMVVRGAPAIGVAAAYGVALAAREAAADDREEFLAELEEAA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  88 AYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIAT 167
Cdd:COG0182   83 EYLAATRPTAVNLFWALDRMLAALEELPSVEEIREALLAEALAIADEDVAANRAIGEHGAELIPDGDTILTHCNAGALAT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 168 SRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGD 247
Cdd:COG0182  163 VGYGTALGVIRAAHEAGKLIHVYADETRPLLQGARLTAWELMQDGIPVTLITDNAAGHLMQRGKVDAVIVGADRIAANGD 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 248 TANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISG 327
Cdd:COG0182  243 VANKIGTYGLAVLAKHHGIPFYVAAPTSTIDLSLPDGEDIPIEERDPDEVTHVGGRRIAPEGVPVYNPAFDVTPAELITA 322
                        330       340
                 ....*....|....*....|.
gi 494884896 328 IITEKGIVTGSYTEEIEQLFA 348
Cdd:COG0182  323 IITEKGVIRPPYEENLAKLFP 343
salvage_mtnA TIGR00512
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ...
9-337 0e+00

S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273112 [Multi-domain]  Cd Length: 335  Bit Score: 513.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896    9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKA 88
Cdd:TIGR00512   1 RAIKWSRGSLEILDQRLLPHESEYIEVTTVEDVADAIRDMRVRGAPAIGIVAAYGLALAAREGETDEGEEFKAFLEEKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   89 YLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQ------IMTICNA 162
Cdd:TIGR00512  81 YLVSSRPTAVNLSWALDRMRAALREAKTVADIKEALLAEAERILEEDLEDNRAIGENGAALIKKGVAakepvrVLTHCNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  163 GSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRI 242
Cdd:TIGR00512 161 GSLATAGYGTALGVIRSAHEKGRLEHVYADETRPYNQGARLTAWELVQEGIPATLITDSMAAHLMKHGEVDAVIVGADRI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  243 AKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPG 322
Cdd:TIGR00512 241 AANGDTANKIGTYQLAILAKHHGVPFYVAAPTSTIDLELADGAEIPIEERPPEEVTHVGGVRIAPPGIGVWNPAFDVTPA 320
                         330
                  ....*....|....*
gi 494884896  323 SLISGIITEKGIVTG 337
Cdd:TIGR00512 321 ELITGIITEKGVITP 335
IF-2B pfam01008
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
49-336 8.35e-112

Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.


Pssm-ID: 395798 [Multi-domain]  Cd Length: 281  Bit Score: 326.94  E-value: 8.35e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   49 KVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIR---DAISINEAKTTLV 125
Cdd:pfam01008   1 KVRGSPAIAIAALEGLLLVIQDARTPTVAELKEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLalhSSSDVEEAKESLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  126 HEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGsiatsrygTALAPFYLAKQKDLGLHIYACETRPVLQGsRLTA 205
Cdd:pfam01008  81 EAADEFIDEIEEARRKIGAIAAELIKDGDTILTHCNSG--------TVLGVLRAAHKEGKRFRVIVTESRPRLQG-RLTA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  206 WELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGD 285
Cdd:pfam01008 152 KELVQAGIPVTLITDSAVGYVMQE--VDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDE 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 494884896  286 QIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVT 336
Cdd:pfam01008 230 DIFIEERDPEEVLYRTGVRIAPPNLKVRNPAFDYTPPELITLIITEVGVLP 280
 
Name Accession Description Interval E-value
mtnA PRK05720
methylthioribose-1-phosphate isomerase; Reviewed
7-349 0e+00

methylthioribose-1-phosphate isomerase; Reviewed


Pssm-ID: 235578  Cd Length: 344  Bit Score: 565.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK05720   2 QPRPVAWKDGAVRILDQRKLPHEVEYVELTTAEEVADAIRDMVVRGAPAIGIAAAYGMALAAREDASDDGEEFLKKLEEA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  87 KAYLNSSRPTAVNLAWALDRLTDSIRdAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK05720  82 AAYLAASRPTAVNLFWALDRMREVLA-PLPGAERKAALEEEAIEIHEEDVEINRAIGEHGLTLIRKGQGILTHCNAGWLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK05720 161 TAGYGTALAPIYAAKEKGIDIHVYADETRPRLQGARLTAWELYQAGIDVTVITDNMAAHLMQTGKIDAVIVGADRIAANG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 DTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK05720 241 DVANKIGTYQLAIAAKYHGVPFYVAAPSSTIDLTLADGKEIPIEERDPEEVTEVGGVRIAPEGVKVYNPAFDVTPAELIT 320
                        330       340
                 ....*....|....*....|...
gi 494884896 327 GIITEKGIVTGSYTEEIEQLFAD 349
Cdd:PRK05720 321 GIITEKGIVAPPDTANLAALFPE 343
MtnA COG0182
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ...
8-348 0e+00

5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];


Pssm-ID: 439952  Cd Length: 343  Bit Score: 557.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   8 PRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVK 87
Cdd:COG0182    3 VRTIWWDGGALVLLDQTLLPHEEEYVELTTVEDVAEAIRDMVVRGAPAIGVAAAYGVALAAREAAADDREEFLAELEEAA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  88 AYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIAT 167
Cdd:COG0182   83 EYLAATRPTAVNLFWALDRMLAALEELPSVEEIREALLAEALAIADEDVAANRAIGEHGAELIPDGDTILTHCNAGALAT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 168 SRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGD 247
Cdd:COG0182  163 VGYGTALGVIRAAHEAGKLIHVYADETRPLLQGARLTAWELMQDGIPVTLITDNAAGHLMQRGKVDAVIVGADRIAANGD 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 248 TANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISG 327
Cdd:COG0182  243 VANKIGTYGLAVLAKHHGIPFYVAAPTSTIDLSLPDGEDIPIEERDPDEVTHVGGRRIAPEGVPVYNPAFDVTPAELITA 322
                        330       340
                 ....*....|....*....|.
gi 494884896 328 IITEKGIVTGSYTEEIEQLFA 348
Cdd:COG0182  323 IITEKGVIRPPYEENLAKLFP 343
salvage_mtnA TIGR00512
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ...
9-337 0e+00

S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273112 [Multi-domain]  Cd Length: 335  Bit Score: 513.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896    9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKA 88
Cdd:TIGR00512   1 RAIKWSRGSLEILDQRLLPHESEYIEVTTVEDVADAIRDMRVRGAPAIGIVAAYGLALAAREGETDEGEEFKAFLEEKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   89 YLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQ------IMTICNA 162
Cdd:TIGR00512  81 YLVSSRPTAVNLSWALDRMRAALREAKTVADIKEALLAEAERILEEDLEDNRAIGENGAALIKKGVAakepvrVLTHCNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  163 GSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRI 242
Cdd:TIGR00512 161 GSLATAGYGTALGVIRSAHEKGRLEHVYADETRPYNQGARLTAWELVQEGIPATLITDSMAAHLMKHGEVDAVIVGADRI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  243 AKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPG 322
Cdd:TIGR00512 241 AANGDTANKIGTYQLAILAKHHGVPFYVAAPTSTIDLELADGAEIPIEERPPEEVTHVGGVRIAPPGIGVWNPAFDVTPA 320
                         330
                  ....*....|....*
gi 494884896  323 SLISGIITEKGIVTG 337
Cdd:TIGR00512 321 ELITGIITEKGVITP 335
eIF-2B_rel TIGR00524
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes ...
35-337 4.22e-165

eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins. [Unknown function, General]


Pssm-ID: 273119 [Multi-domain]  Cd Length: 303  Bit Score: 462.68  E-value: 4.22e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   35 LETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIRDA 114
Cdd:TIGR00524   1 CRTYEDVAEAIKSMVVRGAPAIGVAAAYGLALAALKISHVNVEEFKEDLEKAADFLLSTRPTAVNLFWALDRVLNSLKSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  115 ISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIATSRYGTALAPFYLAKQKDLGLHIYACET 194
Cdd:TIGR00524  81 ESVEEFKESLLREAIEIINEDLETNRKIGENGAKLIKDGDTVLTHCNAGALATSGYGTALGVIRSAWEDGKRIRVIADET 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  195 RPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPL 274
Cdd:TIGR00524 161 RPRNQGSRLTAWELVQDGIPVTLITDSAAAYFMQTGEIDAVIVGADRIARNGDVANKIGTYQLAVLAKEFRIPFFVAAPL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494884896  275 STFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVTG 337
Cdd:TIGR00524 241 STFDPKTSTGEDIIIEERDPEEVAQVGGVRIAPLGVKVYNPAFDITPHDLIDAIITEKGIITP 303
PRK06036 PRK06036
S-methyl-5-thioribose-1-phosphate isomerase;
9-335 3.45e-120

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 180362  Cd Length: 339  Bit Score: 350.18  E-value: 3.45e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   9 RSVEWKETY--IRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK06036   2 RTIDWNDESnsVKLIDQTLLPEEYKVIECKTLESLCEAIKSLRVRGAPALGAAGGYGIALAARLSKAKDVDELLKDLKVA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  87 KAYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIA 166
Cdd:PRK06036  82 AETLKSTRPTAVNLSWGVDRVLKAALDAEDVEEIRDIALREAERIAEEDVARNKLIGKHGAKLLEDGDTVLTHCNAGRLA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 167 TSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNG 246
Cdd:PRK06036 162 CVDWGTALGVIRSAVEQGKEIKVIACETRPLNQGSRLTTWELMQDNIPVTLITDSMAGIVMRQGMVDKVIVGADRITRDA 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 247 dTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDqIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLIS 326
Cdd:PRK06036 242 -VFNKIGTYTHSVLAKEHEIPFYVAAPLSTFDFEGWEGS-VKIEERDPDELRYCGKTQIAPKDVPVYNPAFDATPMENVT 319

                 ....*....
gi 494884896 327 GIITEKGIV 335
Cdd:PRK06036 320 AIITEKGVF 328
IF-2B pfam01008
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
49-336 8.35e-112

Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.


Pssm-ID: 395798 [Multi-domain]  Cd Length: 281  Bit Score: 326.94  E-value: 8.35e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   49 KVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIR---DAISINEAKTTLV 125
Cdd:pfam01008   1 KVRGSPAIAIAALEGLLLVIQDARTPTVAELKEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLalhSSSDVEEAKESLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  126 HEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGsiatsrygTALAPFYLAKQKDLGLHIYACETRPVLQGsRLTA 205
Cdd:pfam01008  81 EAADEFIDEIEEARRKIGAIAAELIKDGDTILTHCNSG--------TVLGVLRAAHKEGKRFRVIVTESRPRLQG-RLTA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  206 WELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGD 285
Cdd:pfam01008 152 KELVQAGIPVTLITDSAVGYVMQE--VDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDE 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 494884896  286 QIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVT 336
Cdd:pfam01008 230 DIFIEERDPEEVLYRTGVRIAPPNLKVRNPAFDYTPPELITLIITEVGVLP 280
PRK05772 PRK05772
S-methyl-5-thioribose-1-phosphate isomerase;
9-346 1.07e-111

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 168237  Cd Length: 363  Bit Score: 329.41  E-value: 1.07e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKA 88
Cdd:PRK05772  17 LPIIWKDNTLTLLDQSLLPFETVYVDLKTVEEVALAIRNMQVRGAPAIGITAGYGMVLALIENNVKTLDDAIRELTRAKT 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  89 YLNSSRPTAVNLAWALDRLTDSIRDAI------SINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNA 162
Cdd:PRK05772  97 ILDSARPTAVNLVWATSRMLNKAKNTVesgnakSVNELIELLKVEAKKIFEEEYDAEIQMGLYGLEKLNDGDTVLTQCNA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 163 GSIAT-SRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADR 241
Cdd:PRK05772 177 GGLATgTGLGTALAPVKLAKALGMSVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTAVGLVMYKDMVNNVMVGADR 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 242 IAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLqIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITP 321
Cdd:PRK05772 257 ILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSTFDL-KSDVNDVKIEERDPNEVRTIRGVPITPEDVNVYNPVFDVTP 335
                        330       340
                 ....*....|....*....|....*
gi 494884896 322 GSLISGIITEKGIVTGSYTEEIEQL 346
Cdd:PRK05772 336 PKYITGIITEKGIIYPPFHKNIRKI 360
PRK08334 PRK08334
S-methyl-5-thioribose-1-phosphate isomerase;
7-347 1.56e-107

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 169386  Cd Length: 356  Bit Score: 318.83  E-value: 1.56e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   7 IPRSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADV 86
Cdd:PRK08334  13 LPRSVEYEEGKVYMIDQRLLPREFKVIELRTVEEVAEAIKTMTVRGAPAIGAAAAFGLALYAETSKAKTKDEFMDGFYKA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  87 KAYLNSSRPTAVNLAWALDRLTDSIRDAI--SINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDqIMTICNAGS 164
Cdd:PRK08334  93 YETLKNTRPTAVNLFWALNRIKKLVEEHLedPLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPEGN-VLTHCNAGS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 165 IATSRYGTALAPF-YLAKQKDLGLhIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIA 243
Cdd:PRK08334 172 LATVHLGTVGAVLrVMHKDGTLKL-LWVDETRPVLQGARLSAWEYHYDGIPLKLISDNMAGFVMQQGKVDAIIVGADRIV 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 244 KNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPeDVPVFNPAFDITPGS 323
Cdd:PRK08334 251 ANGDFANKIGTYTLAVLAKEHGIPFFTVAPLSTIDMSLKSGKEIPIEERSPEEVLTCGGCRIAP-DVDVYNPAFDVTPHK 329
                        330       340
                 ....*....|....*....|....
gi 494884896 324 LISGIITEKGIVTGSYTEEIEQLF 347
Cdd:PRK08334 330 YLTGIITDRGVVWPPFERNLKKLF 353
PRK06371 PRK06371
S-methyl-5-thioribose-1-phosphate isomerase;
9-346 1.09e-99

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 180547  Cd Length: 329  Bit Score: 297.97  E-value: 1.09e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   9 RSVEWKETYIRILNQQKLPDVTEYAELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDlsdfrrqfaDVKA 88
Cdd:PRK06371  13 KAVWYEDGEVKLIDQRKLPDKIEIFEAKNSDDVAYAIKNMVVRGAPAIGVTAAYGLAMASKNGENMD---------EAVE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  89 YLNSSRPTAVNLAWALDRLtdsirdaiSINEAKttlVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIATS 168
Cdd:PRK06371  84 KIRSTRPTAYDLFKAIRYM--------NSNEFD---MNAARRYAMEIIGRSKKIGEYGNELIKNGARILTHCNAGALAVV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 169 RYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADRIAKNGDT 248
Cdd:PRK06371 153 DWGTALAPIRIAHRNGKNIFVFVDETRPRLQGARLTAWELAQEGIDHAIIADNAAGYFMRKKEIDLVIVGADRIASNGDF 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 249 ANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITPGSLISGI 328
Cdd:PRK06371 233 ANKIGTYEKAVLAKVNGIPFYVAAPGSTFDFSIKSGDEIPIEERDENEVLEINGCRIGPQESHARNPAFDVTPNEYVTGF 312
                        330
                 ....*....|....*...
gi 494884896 329 ITEKGIVTgsyTEEIEQL 346
Cdd:PRK06371 313 ITEYGIFK---PNELWKL 327
GCD2 COG1184
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ...
43-334 1.83e-64

Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440797 [Multi-domain]  Cd Length: 304  Bit Score: 206.62  E-value: 1.83e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  43 DAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKT 122
Cdd:COG1184    9 EEIREMEIHGAARIARAAAEALRDLAERSRAADPEEFRRELEAAARALRRARPSAASLPNAVRRVLARVADGETVEEARE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 123 TLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGsiatsrygTALAPFYLAKQKDLGLHIYACETRPVLQGsR 202
Cdd:COG1184   89 AVLEAADEFIERAEEAKERAAEIAAKRIRDGDTILTHSNSS--------TVLAAIEAAVPQGKDIRVYVTESRPRYQG-R 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 203 LTAWELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAplSTFDLQIE 282
Cdd:COG1184  160 ITARELAEAGVPVTLIVDSAARHFLKE--VDRVVVGADTITADGAVVNKIGTSPLALAAREAGVPVTVAA--ETYKFSPE 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 494884896 283 NGDQIPIEERDPDEVrqisgIRTAPEDVPVFNPAFDITPGSLISGIITEKGI 334
Cdd:COG1184  236 TFELVEIEERDPSEV-----YDEEPEGVTVRNPAFDVTPPDLIDAIITERGV 282
PRK08535 PRK08535
ribose 1,5-bisphosphate isomerase;
39-335 2.50e-58

ribose 1,5-bisphosphate isomerase;


Pssm-ID: 236282 [Multi-domain]  Cd Length: 310  Bit Score: 190.88  E-value: 2.50e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  39 EDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALdRLTDSIRDAISIN 118
Cdd:PRK08535   8 LETAEKIKTMEIRGAGRIARAAAEALKDQAEKSDAESPEEFKAEMRAAANILISTRPTAVSLPNAV-RYVMRYYSGETVE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 119 EAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAgSIATSRYGTALapfylakqkDLGLHI--YACETRP 196
Cdd:PRK08535  87 EARESVIERAEEFIESSENAVEKIGEIGAKRIRDGDVIMTHCNS-SAALSVIKTAH---------EQGKDIevIATETRP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 197 VLQGsRLTAWELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAplST 276
Cdd:PRK08535 157 RNQG-HITAKELAEYGIPVTLIVDSAVRYFMKD--VDKVVVGADAITANGAVINKIGTSQIALAAHEARVPFMVAA--ET 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494884896 277 FDLQIEN--GDQIPIEERDPDEVRQISGIRTAPEdVPVFNPAFDITPGSLISGIITEKGIV 335
Cdd:PRK08535 232 YKFSPKTllGELVEIEERDPTEVLPEEILAKLPG-VKVRNPAFDVTPPEYIDAIITEIGAI 291
ribulose_e2b2 TIGR00511
ribose-1,5-bisphosphate isomerase, e2b2 family; The delineation of this family was based ...
35-335 5.02e-51

ribose-1,5-bisphosphate isomerase, e2b2 family; The delineation of this family was based originally, in part, on a discussion and neighbor-joining phylogenetic study by Kyrpides and Woese of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. Recently, Sato, et al. assigned the function ribulose-1,5 bisphosphate isomerase. [Energy metabolism, Other]


Pssm-ID: 188057  Cd Length: 301  Bit Score: 171.83  E-value: 5.02e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896   35 LETKEDvfdaIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRRQFADVKAYLNSSRPTAVNLAWALdRLTDSIRDA 114
Cdd:TIGR00511   3 LETAEK----IRTMEIRGAGRIARAAAAALREQAEKSDAASPEEFRAEMRAAANILISTRPTAVSLPNAL-RYVLKYMSG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  115 ISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAgSIATSRYGTALapfylakqkDLGLHI--YAC 192
Cdd:TIGR00511  78 ADVETLRQSVIERADEFINRSEKAQERIGEIGAKRIRDGDVIMTHCNS-EAALSVIKTAF---------EQGKDIevIVT 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896  193 ETRPVLQGsRLTAWELMQGGIDVTLITDSMAAHTMKEkhISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAA 272
Cdd:TIGR00511 148 ETRPRNQG-HITAKELRDYGIPVTLIVDSAARYYMKE--VDHVVVGADAITANGAVINKIGTSQLALAAREARVPFMVAA 224
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494884896  273 PLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPeDVPVFNPAFDITPGSLISGIITEKGIV 335
Cdd:TIGR00511 225 ETYKFHPKTITGELVEIEERDPTEVLDEEDLKQLG-NVKVRNPAFDVTPPEYVDAIITERGQI 286
PRK06372 PRK06372
translation initiation factor IF-2B subunit delta; Provisional
111-338 1.70e-19

translation initiation factor IF-2B subunit delta; Provisional


Pssm-ID: 235788 [Multi-domain]  Cd Length: 253  Bit Score: 86.50  E-value: 1.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 111 IRDAISINEAKTTLVHEAIQIQIEDEEtcRMIGQNALHLFkkgdqimticNAGSIATSRYGTALAPFYLAKQKDLglHIY 190
Cdd:PRK06372  48 VRNVCDSIISGPNLRPKNLKLGIEKHE--KMAIEHAKPLF----------NDSVIGTISSSQVLKAFISSSEKIK--SVY 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 191 ACETRPVLQGSRLtAWELMQGGIDVTLITDsmAAHTMKEKHISAVIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFV 270
Cdd:PRK06372 114 ILESRPMLEGIDM-AKLLVKSGIDVVLLTD--ASMCEAVLNVDAVIVGSDSVLYDGGLIHKNGTFPLALCARYLKKPFYS 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 494884896 271 AaplsTFDLQIENGdqipIEERDPDEVRQISGIRTApEDVPVFNPAFDITPGSLISGIITEKGIVTGS 338
Cdd:PRK06372 191 L----TISMKIERN----FLYSTYPNFKNHPCSEWN-IDIPCINRYFDKTPPDLIDYYINENGFVKPS 249
PRK08335 PRK08335
translation initiation factor IF-2B subunit alpha; Validated
136-335 2.09e-18

translation initiation factor IF-2B subunit alpha; Validated


Pssm-ID: 169387  Cd Length: 275  Bit Score: 84.06  E-value: 2.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 136 EETCRMIGQNALHLFKKGDQIMTicnagsiaTSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLtAWELMQGGIDV 215
Cdd:PRK08335  93 EEAKREIGNIGSELIDDGDVIIT--------HSFSSAVLEILKTAKRKGKRFKVILTESAPDYEGLAL-ANELEFLGIEF 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494884896 216 TLITDSMAAHTMKEKHISavIVGADRIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDqIPIEERdpD 295
Cdd:PRK08335 164 EVITDAQLGLFAKEATLA--LVGADNVTRDGYVVNKAGTYLLALACHDNGVPFYVAAETFKFHPELKSEE-VELVER--P 238
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 494884896 296 EVRQISGIRtapedvpvfNPAFDITPGSLISGIITEKGIV 335
Cdd:PRK08335 239 YARQGHRVR---------NVLFDVTPWKYVRGIITELGIL 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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