NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|494885261|ref|WP_007611309|]
View 

MULTISPECIES: orotate phosphoribosyltransferase [Bacillus]

Protein Classification

orotate phosphoribosyltransferase( domain architecture ID 10785483)

orotate phosphoribosyltransferase catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

CATH:  3.40.50.2020
EC:  2.4.2.-
Gene Ontology:  GO:0046132|GO:0004588|GO:0000287
PubMed:  11751055
SCOP:  4000253

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 1-203 7.46e-86

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 440229  Cd Length: 201  Bit Score: 252.00  E-value: 7.46e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   1 MKQAIAKHLLHIEAVFLRPnepFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFPEAEMIAGTATAGIPHAA 80
Cdd:COG0461    3 YKEELAELLLEIGALLFGH---FTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGPEFDAVAGPATGGIPLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  81 LLADRTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGlPKAKEA 160
Cdd:COG0461   80 AVARALGLPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDRE-EGAAEN 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 494885261 161 FKKAGLPYYSLTDYDTLIEVALENGTIHSADIEKLKSWKLNPE 203
Cdd:COG0461  159 LEEAGVPLHSLLTLDDLLELLKEKGYIDPEELEALEAYREKPG 201
 
Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 1-203 7.46e-86

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 252.00  E-value: 7.46e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   1 MKQAIAKHLLHIEAVFLRPnepFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFPEAEMIAGTATAGIPHAA 80
Cdd:COG0461    3 YKEELAELLLEIGALLFGH---FTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGPEFDAVAGPATGGIPLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  81 LLADRTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGlPKAKEA 160
Cdd:COG0461   80 AVARALGLPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDRE-EGAAEN 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 494885261 161 FKKAGLPYYSLTDYDTLIEVALENGTIHSADIEKLKSWKLNPE 203
Cdd:COG0461  159 LEEAGVPLHSLLTLDDLLELLKEKGYIDPEELEALEAYREKPG 201
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 1-203 2.13e-81

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 240.83  E-value: 2.13e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   1 MKQAIAKHLLHIEAVflrPNEPFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFPEAEMIAGTATAGIPHAA 80
Cdd:PRK00455   4 YAREFIEFLLEIGAL---LFGHFTLSSGRKSPYYFDCRKLLSYPEALALLGRFLAEAIKDSGIEFDVVAGPATGGIPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  81 LLADRTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGlPKAKEA 160
Cdd:PRK00455  81 AVARALDLPAIFVRKEAKDHGEGGQIEGRRLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDRQ-SAAQEV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 494885261 161 FKKAGLPYYSLTDYDTLIEVAlENGTIHSADIEKLKSWKLNPE 203
Cdd:PRK00455 160 FADAGVPLISLITLDDLLEYA-EEGPLCKEGLPAVKAYRRNYG 201
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 7-177 4.69e-61

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 188.41  E-value: 4.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261    7 KHLLHIEAVFLrpNEpFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFpEAEMIAGTATAGIPHAALLAD-- 84
Cdd:TIGR00336   1 ELLLEVQALKF--GE-FTLSSGRKSPYYFNIKLFNTGPELANLIARYAAAIIKSHL-EFDVIAGPALGGIPIATAVSVkl 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   85 ---RTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGLPKAKEAF 161
Cdd:TIGR00336  77 akpGGDIPLCFNRKEAKDHGEGGNIEGELLEGDKVVVVEDVITTGTSILEAVEIIQAAGGQVAGVIIAVDRQERSAGQEF 156

                         170
                  ....*....|....*..
gi 494885261  162 KKA-GLPYYSLTDYDTL 177
Cdd:TIGR00336 157 EKEyGLPVISLITLKDL 173
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 54-171 1.57e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 85.91  E-value: 1.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  54 LGKLLKEHFPEAEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAHGKGNQ-------IEGAIKKGQKTVVIEDLISTG 126
Cdd:cd06223    5 LAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSepyglelPLGGDVKGKRVLLVDDVIATG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 494885261 127 GSVLEAAAALQREGAEVLGVISIFTYGLPKAKEAfKKAGLPYYSL 171
Cdd:cd06223   85 GTLLAAIELLKEAGAKVVGVAVLLDKPEGGAREL-ASPGDPVYSL 128
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 51-150 2.17e-09

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 53.91  E-value: 2.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   51 ADGLGKLLKEHFPEAE----MIAGTATAGIPHAALLADRTGAPMCYVRSKpKAHGKGNQIEGA-----IKKGQKTVVIED 121
Cdd:pfam00156  12 LKAVARLAAQINEDYGgkpdVVVGILRGGLPFAGILARRLDVPLAFVRKV-SYNPDTSEVMKTssalpDLKGKTVLIVDD 90

                          90       100
                  ....*....|....*....|....*....
gi 494885261  122 LISTGGSVLEAAAALQREGAEVLGVISIF 150
Cdd:pfam00156  91 ILDTGGTLLKVLELLKNVGPKEVKIAVLI 119
 
Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 1-203 7.46e-86

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 252.00  E-value: 7.46e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   1 MKQAIAKHLLHIEAVFLRPnepFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFPEAEMIAGTATAGIPHAA 80
Cdd:COG0461    3 YKEELAELLLEIGALLFGH---FTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGPEFDAVAGPATGGIPLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  81 LLADRTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGlPKAKEA 160
Cdd:COG0461   80 AVARALGLPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDRE-EGAAEN 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 494885261 161 FKKAGLPYYSLTDYDTLIEVALENGTIHSADIEKLKSWKLNPE 203
Cdd:COG0461  159 LEEAGVPLHSLLTLDDLLELLKEKGYIDPEELEALEAYREKPG 201
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 1-203 2.13e-81

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 240.83  E-value: 2.13e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   1 MKQAIAKHLLHIEAVflrPNEPFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFPEAEMIAGTATAGIPHAA 80
Cdd:PRK00455   4 YAREFIEFLLEIGAL---LFGHFTLSSGRKSPYYFDCRKLLSYPEALALLGRFLAEAIKDSGIEFDVVAGPATGGIPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  81 LLADRTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGlPKAKEA 160
Cdd:PRK00455  81 AVARALDLPAIFVRKEAKDHGEGGQIEGRRLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDRQ-SAAQEV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 494885261 161 FKKAGLPYYSLTDYDTLIEVAlENGTIHSADIEKLKSWKLNPE 203
Cdd:PRK00455 160 FADAGVPLISLITLDDLLEYA-EEGPLCKEGLPAVKAYRRNYG 201
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 7-177 4.69e-61

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 188.41  E-value: 4.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261    7 KHLLHIEAVFLrpNEpFTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHFpEAEMIAGTATAGIPHAALLAD-- 84
Cdd:TIGR00336   1 ELLLEVQALKF--GE-FTLSSGRKSPYYFNIKLFNTGPELANLIARYAAAIIKSHL-EFDVIAGPALGGIPIATAVSVkl 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   85 ---RTGAPMCYVRSKPKAHGKGNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGLPKAKEAF 161
Cdd:TIGR00336  77 akpGGDIPLCFNRKEAKDHGEGGNIEGELLEGDKVVVVEDVITTGTSILEAVEIIQAAGGQVAGVIIAVDRQERSAGQEF 156

                         170
                  ....*....|....*..
gi 494885261  162 KKA-GLPYYSLTDYDTL 177
Cdd:TIGR00336 157 EKEyGLPVISLITLKDL 173
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 54-171 1.57e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 85.91  E-value: 1.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  54 LGKLLKEHFPEAEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAHGKGNQ-------IEGAIKKGQKTVVIEDLISTG 126
Cdd:cd06223    5 LAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSepyglelPLGGDVKGKRVLLVDDVIATG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 494885261 127 GSVLEAAAALQREGAEVLGVISIFTYGLPKAKEAfKKAGLPYYSL 171
Cdd:cd06223   85 GTLLAAIELLKEAGAKVVGVAVLLDKPEGGAREL-ASPGDPVYSL 128
PRK13809 PRK13809
orotate phosphoribosyltransferase; Provisional
 23-192 1.82e-19

orotate phosphoribosyltransferase; Provisional


Pssm-ID: 184340  Cd Length: 206  Bit Score: 82.19  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  23 FTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLlKEHFPeAEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAHGK 102
Cdd:PRK13809  28 FILASGEETPIYVDMRLVISSPEVLQTIATLIWRL-RPSFN-SSLLCGVPYTALTLATSISLKYNIPMVLRRKELKNVDP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261 103 GNQI--EGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGvISIFTYGLPKAKEAFKKAGLPYYSLTDYDTLIEV 180
Cdd:PRK13809 106 SDAIkvEGLFTPGQTCLVINDMVSSGKSIIETAVALEEEGLVVRE-ALVFLDRQKGACQPLGPQGIKLSSVFTVPDLIKS 184

                        170
                 ....*....|..
gi 494885261 181 ALENGTIHSADI 192
Cdd:PRK13809 185 LISYGKLSSGDL 196
PRK05500 PRK05500
bifunctional orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase;
23-187 1.25e-18

bifunctional orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase;


Pssm-ID: 180119 [Multi-domain]  Cd Length: 477  Bit Score: 83.19  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  23 FTWASGILSPIYCDNRLTLSYPKVRNDVADGLGKLLKEHfpEAEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAHGK 102
Cdd:PRK05500 305 YVQASGATFSYYIDLRKIISNPQLFHQVLSAYAEILKNL--TFDRIAGIPYGSLPTATGLALHLHHPMIFPRKEVKAHGT 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261 103 GNQIEGAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYGlPKAKEAFKKAGLPYYSLTDYDTLIEVAL 182
Cdd:PRK05500 383 RRLIEGNFHPGETVVVVDDILITGKSVMEGAEKLKSAGLNVRDIVVFIDHE-QGVKDKLQSHGYQAYSVLTISEITETLY 461


                 ....*
gi 494885261 183 ENGTI 187
Cdd:PRK05500 462 QAGRI 466
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 41-175 1.21e-16

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 73.96  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  41 LSYPKVRNDVADGLGKLLKEHfpEAEMIAGTATAGIPHAALLADRTGAPMCYVRsKPkahGKG---------------NQ 105
Cdd:PRK02304  30 LADPEAFREVIDALVERYKDA--DIDKIVGIEARGFIFGAALAYKLGIGFVPVR-KP---GKLpretisesyeleygtDT 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494885261 106 IE---GAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFtyGLPKAKEAFKKAGLPYYSLTDYD 175
Cdd:PRK02304 104 LEihkDAIKPGDRVLIVDDLLATGGTLEAAIKLLERLGAEVVGAAFVI--ELPDLGGREKLEGYPVKSLVKFD 174
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 54-174 3.47e-16

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 72.80  E-value: 3.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  54 LGKLLKEHFPEAE--MIAGTATAGIPHAALLADRTGAPMCYVRSKPKA------------HGKGNQIE---GAIKKGQKT 116
Cdd:COG0503   36 AGDELAERFADKGidKVVGIEARGFILAAALAYALGVPFVPARKPGKLpgetvseeydleYGTGDTLElhkDALKPGDRV 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 494885261 117 VVIEDLISTGGSvLEAAAALQRE-GAEVLGVISIFTYGLPKAKEAFKkaGLPYYSLTDY 174
Cdd:COG0503  116 LIVDDLLATGGT-AKAAIKLVEEaGAEVVGIAFLIELGFLGGREKLR--DYPVESLLTL 171
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 50-150 1.71e-11

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 60.65  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  50 VADGLGKLLKEHFPEAEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAHGKGNQIEGAIK------KGQKTVVIEDLI 123
Cdd:PRK02277  71 IASAMADMLEKEDEEVDVVVGIAKSGVPLATLVADELGKDLAIYHPKKWDHGEGEKKTGSFSrnfasvEGKRCVIVDDVI 150

                         90       100
                 ....*....|....*....|....*..
gi 494885261 124 STGGSVLEAAAALQREGAEVLGVISIF 150
Cdd:PRK02277 151 TSGTTMKETIEYLKEHGGKPVAVVVLI 177
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 50-153 5.13e-10

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 56.14  E-value: 5.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  50 VADGLGKLLKehfPEAEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAH--------------GKGNQI-----EGAI 110
Cdd:PRK07322  41 AAEALAKRLP---TEVDVLVTPETKGIPLAHALSRRLGKPYVVARKSRKPYmqdpiiqevvsittGKPQLLvldgaDAEK 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 494885261 111 KKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISIFTYG 153
Cdd:PRK07322 118 LKGKRVAIVDDVVSTGGTLTALERLVERAGGQVVAKAAIFAEG 160
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 51-150 2.17e-09

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 53.91  E-value: 2.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261   51 ADGLGKLLKEHFPEAE----MIAGTATAGIPHAALLADRTGAPMCYVRSKpKAHGKGNQIEGA-----IKKGQKTVVIED 121
Cdd:pfam00156  12 LKAVARLAAQINEDYGgkpdVVVGILRGGLPFAGILARRLDVPLAFVRKV-SYNPDTSEVMKTssalpDLKGKTVLIVDD 90

                          90       100
                  ....*....|....*....|....*....
gi 494885261  122 LISTGGSVLEAAAALQREGAEVLGVISIF 150
Cdd:pfam00156  91 ILDTGGTLLKVLELLKNVGPKEVKIAVLI 119
PLN02293 PLN02293
adenine phosphoribosyltransferase
 108-177 3.73e-08

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 51.21  E-value: 3.73e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494885261 108 GAIKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVL---GVIsiftyGLPKAKEAFKKAGLPYYSLTDYDTL 177
Cdd:PLN02293 120 GAVEPGERALVIDDLIATGGTLCAAINLLERAGAEVVecaCVI-----ELPELKGREKLNGKPLFVLVESRGI 187
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 72-175 1.25e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 44.60  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  72 ATAGIPHAALLADRTGAPMCYVRsKPKAHGKGNQIE-----------------GAIKKGQKTVVIEDLISTgGSVLEAAA 134
Cdd:PRK08558 119 ATDGIPLAVAIASYFGADLVYAK-KSKETGVEKFYEeyqrlasgievtlylpaSALKKGDRVLIVDDIIRS-GETQRALL 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 494885261 135 ALQRE-GAEVLGV---ISIFTYGLPKAKEafkKAGLPYYSLTDYD 175
Cdd:PRK08558 197 DLARQaGADVVGVfflIAVGEVGIDRARE---ETDAPVDALYTLE 238
PRK12560 PRK12560
adenine phosphoribosyltransferase; Provisional
 44-147 2.29e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 183595  Cd Length: 187  Bit Score: 43.23  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  44 PKVRNDVADGLGKLLKEHFpeaEMIAGTATAGIPHAALLADRTGAPMCYVRSKPKAHGKGNQI---------EG-----A 109
Cdd:PRK12560  34 PKVLKETAKEIIKYIDKDI---DKIVTEEDKGAPLATPVSLLSGKPLAMARWYPYSLSELNYNvveigseyfEGvvylnG 110

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 494885261 110 IKKGQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVI 147
Cdd:PRK12560 111 IEKGDRVAIIDDTLSTGGTVIALIKAIENSGGIVSDVI 148
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
83-173 7.50e-05

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 42.63  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  83 ADRTG-APMCYV---RSKPKA-HGKGNQIEGAIKkGQKTVVIEDLISTGGSVLEAAAALQREGAEvlGVISIFTYGL--P 155
Cdd:PRK03092 167 ADRLGgAPLAFIhktRDPTVPnQVVANRVVGDVE-GRTCVLVDDMIDTGGTIAGAVRALKEAGAK--DVIIAATHGVlsG 243

                         90
                 ....*....|....*...
gi 494885261 156 KAKEAFKKAGLPYYSLTD 173
Cdd:PRK03092 244 PAAERLKNCGAREVVVTD 261
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
82-154 2.28e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 40.87  E-value: 2.28e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494885261  82 LADRTGAPMCYV-RSKPKAhgkgNQIE-----GAIKkGQKTVVIEDLISTGGSVLEAAAALQREGAEvlGVISIFTYGL 154
Cdd:PRK01259 176 LAKRLDADLAIIdKRRPRA----NVSEvmniiGDVE-GRDCILVDDMIDTAGTLCKAAEALKERGAK--SVYAYATHPV 247
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 75-164 2.54e-04

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 41.06  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494885261  75 GIPHAALLADRTGAPMCYVRSKPKAHGKGNQIE--GAIKKgQKTVVIEDLISTGGSVLEAAAALQREGAEVLGVISifTY 152
Cdd:PRK00553 179 GVKRARLIAESLELPLAIIDKRRPKHNVAESINvlGEVKN-KNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMA--TH 255

                         90
                 ....*....|....
gi 494885261 153 GL--PKAKEAFKKA 164
Cdd:PRK00553 256 GLfnKNAIQLFDEA 269
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
117-165 1.46e-03

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 38.77  E-value: 1.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 494885261 117 VVIEDLISTGGSVLEAAAALQREGA---EVLGVISIFTyglPKAKEAFKKAG 165
Cdd:PRK07199 215 VLVDDIVSTGRTLIEAARQLRAAGAaspDCVVVHALFA---GDAYSALAAAG 263
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 88-142 4.14e-03

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 37.37  E-value: 4.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 494885261  88 APMCYVRSKPKAHGKGNQIE--GAIKkGQKTVVIEDLISTGGSVLEAAAALQREGAE 142
Cdd:PLN02369 176 APLAIVDKRRQGHNVAEVMNliGDVK-GKVAIMVDDMIDTAGTITKGAALLHQEGAR 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH