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Conserved domains on  [gi|495023598|ref|WP_007749371|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Enterobacterales]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 1-117 7.72e-60

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member PRK10141:

Pssm-ID: 481199  Cd Length: 117  Bit Score: 179.24  E-value: 7.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495023598   1 MPQFQPLQLFKNLSDETRLSLVLLLREKGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAW 80
Cdd:PRK10141   1 MSFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAW 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 495023598  81 AAAVIEQAYLCQRDDILQLSQQAERNNATTNGKPVCI 117
Cdd:PRK10141  81 AAKIIEQAWLCEQEDVQAIVRNLARQNCSGDSKNICS 117
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-117 7.72e-60

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 179.24  E-value: 7.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495023598   1 MPQFQPLQLFKNLSDETRLSLVLLLREKGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAW 80
Cdd:PRK10141   1 MSFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAW 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 495023598  81 AAAVIEQAYLCQRDDILQLSQQAERNNATTNGKPVCI 117
Cdd:PRK10141  81 AAKIIEQAWLCEQEDVQAIVRNLARQNCSGDSKNICS 117
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-81 2.54e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 100.61  E-value: 2.54e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495023598   8 QLFKNLSDETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAWA 81
Cdd:NF033788   3 ELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-87 1.85e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 96.50  E-value: 1.85e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495023598   8 QLFKNLSDETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAWAAAVIEQ 87
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLLE 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-75 2.30e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 78.11  E-value: 2.30e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495023598  10 FKNLSDETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSP 75
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-76 6.94e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.47  E-value: 6.94e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 495023598    20 SLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPH 76
Cdd:smart00418   1 KILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-60 1.50e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 59.76  E-value: 1.50e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 495023598   15 DETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLL 60
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-117 7.72e-60

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 179.24  E-value: 7.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495023598   1 MPQFQPLQLFKNLSDETRLSLVLLLREKGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAW 80
Cdd:PRK10141   1 MSFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAW 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 495023598  81 AAAVIEQAYLCQRDDILQLSQQAERNNATTNGKPVCI 117
Cdd:PRK10141  81 AAKIIEQAWLCEQEDVQAIVRNLARQNCSGDSKNICS 117
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-81 2.54e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 100.61  E-value: 2.54e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495023598   8 QLFKNLSDETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAWA 81
Cdd:NF033788   3 ELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-87 1.85e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 96.50  E-value: 1.85e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495023598   8 QLFKNLSDETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPHMPAWAAAVIEQ 87
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLLE 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-75 2.30e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 78.11  E-value: 2.30e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495023598  10 FKNLSDETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSP 75
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-76 6.94e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.47  E-value: 6.94e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 495023598    20 SLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSPH 76
Cdd:smart00418   1 KILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-60 1.50e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 59.76  E-value: 1.50e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 495023598   15 DETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGLL 60
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-75 9.91e-09

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 50.26  E-value: 9.91e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495023598   8 QLFKNLSDETRLSLVLLLREKGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGKWIYYRLSP 75
Cdd:COG3398   89 KILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-67 1.88e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.15  E-value: 1.88e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495023598    7 LQLFKNLSDETRLSLVLLLREKGELCVCELTSMLKESQPKISRHLALLRDAGLLIDRRDGK 67
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
5-75 5.74e-08

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 47.34  E-value: 5.74e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495023598   5 QPLQLFKNLSDETRLSLVLLLREKgELCVCELTSMLKESQPKISRHLALLRDAGLL----IDRRDGK-WIYYRLSP 75
Cdd:COG1777    6 DLDRLLDALGNPTRRRILALLSEE-PAYVSELARELGVSRQAVYKHLRKLEEAGLVesyrEGREDGRaRKYYRLSA 80
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
16-75 2.13e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.72  E-value: 2.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495023598  16 ETRLSLVLLLREkGELCVCELTSMLKESQPKISRHLALLRDAGlLIDRRDGKwiyYRLSP 75
Cdd:COG4742   16 EKRKNILLLLAE-GPKTRSELAESLDVSRSTILRQLKELEERG-LIERDDGE---YELTT 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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