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Conserved domains on  [gi|495037632|ref|WP_007763150|]
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MULTISPECIES: uracil phosphoribosyltransferase [Cronobacter]

Protein Classification

uracil phosphoribosyltransferase( domain architecture ID 10011262)

uracil phosphoribosyltransferase catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

EC:  2.4.2.9
Gene Ontology:  GO:0004845|GO:0006223
PubMed:  17384901|9628859

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-208 1.34e-136

uracil phosphoribosyltransferase; Reviewed


:

Pssm-ID: 234653  Cd Length: 209  Bit Score: 380.59  E-value: 1.34e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   1 MKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAG 80
Cdd:PRK00129   2 MKVHVVDHPLIQHKLTLLRDKNTSTKRFRELLEELGRLLAYEATRDLPLEEVEIETPLGKTTGKRIAGKKLVIVPILRAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  81 LGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLV 160
Cdd:PRK00129  82 LGMVDGVLKLIPSARVGHIGLYRDEETLEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 495037632 161 AAPEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:PRK00129 162 AAPEGIKALEEAHPDVEIYTAAIDEKLNEHGYIVPGLGDAGDRLFGTK 209
 
Name Accession Description Interval E-value
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-208 1.34e-136

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 380.59  E-value: 1.34e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   1 MKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAG 80
Cdd:PRK00129   2 MKVHVVDHPLIQHKLTLLRDKNTSTKRFRELLEELGRLLAYEATRDLPLEEVEIETPLGKTTGKRIAGKKLVIVPILRAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  81 LGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLV 160
Cdd:PRK00129  82 LGMVDGVLKLIPSARVGHIGLYRDEETLEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 495037632 161 AAPEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:PRK00129 162 AAPEGIKALEEAHPDVEIYTAAIDEKLNEHGYIVPGLGDAGDRLFGTK 209
upp TIGR01091
uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees ...
 2-208 4.74e-123

uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273438  Cd Length: 207  Bit Score: 346.54  E-value: 4.74e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632    2 KIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAGL 81
Cdd:TIGR01091   1 MVVVVDHPLIKHKLTLLRDKNTDTKEFRELLRELGRLLAYEATRDLELEEVEVETPLGETEGGRILGKKIVLVPILRAGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   82 GMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVA 161
Cdd:TIGR01091  81 GMVDGVLKLIPEAKVGHVGAYRNEETLKPVPYYSKLPEDIDERTVIVLDPMLATGGTMIAALDLLKKRGPKKIKVLSIVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 495037632  162 APEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:TIGR01091 161 APEGIEAVEKAHPDVDIYTAAIDEKLNDNGYIVPGLGDAGDRAFGTK 207
Upp COG0035
Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil ...
 2-208 1.05e-122

Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439805  Cd Length: 209  Bit Score: 345.52  E-value: 1.05e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   2 KIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAGL 81
Cdd:COG0035    3 RVHVVDHPLIQHKLTLLRDKNTDTKEFRRLLEELGRLLAYEATRDLPLEEVEVETPLGKTTGKVLAGKKLVIVPILRAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  82 GMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVA 161
Cdd:COG0035   83 GMLDGVLDLLPSARVGHIGLYRDEETLEPVEYYFKLPEDLEGRTVIVLDPMLATGGSLVAAIDLLKKRGAKDIKIVCLIA 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 495037632 162 APEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:COG0035  163 APEGIERVQEAHPDVDIYTAAIDEELNEKGYIVPGLGDAGDRLFGTK 209
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 7-207 1.56e-85

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 251.26  E-value: 1.56e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632    7 KHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKG-KKITVVPILRAGLGMME 85
Cdd:pfam14681   1 DHPLLKHLLTILRDKSTSGPDFRFASDRIGRLLAYEALRDLPTEEVTVETPLGTTYAGVLFDeKKICGVPILRAGEGMED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   86 GVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCT--SIKVLVLVAAP 163
Cdd:pfam14681  81 GLRDLLPGARVGHIGIQRDEETLQPVEYYNKLPKDISDRTVILLDPMLATGGSAIAAIQVLREHGVPeeNIVVLSVIAAP 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 495037632  164 EGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGT 207
Cdd:pfam14681 161 EGLHRLAAAFPDVKIVTAAVDEELNENGYIVPGLGDAGDRLFGT 204
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 62-183 8.75e-20

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 81.29  E-value: 8.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  62 EIEQIKGKKITVVPILRAGLGMMEGVLE--NVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSM 139
Cdd:cd06223    8 EIREDLLEPDVVVGILRGGLPLAAALARalGLPLAFIRKERKGPGRTPSEPYGLELPLGGDVKGKRVLLVDDVIATGGTL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 495037632 140 IATIDLLKKAGCTSIKVLVLVAAPEGiKALEKAHPDIELYTASI 183
Cdd:cd06223   88 LAAIELLKEAGAKVVGVAVLLDKPEG-GARELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-208 1.34e-136

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 380.59  E-value: 1.34e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   1 MKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAG 80
Cdd:PRK00129   2 MKVHVVDHPLIQHKLTLLRDKNTSTKRFRELLEELGRLLAYEATRDLPLEEVEIETPLGKTTGKRIAGKKLVIVPILRAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  81 LGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLV 160
Cdd:PRK00129  82 LGMVDGVLKLIPSARVGHIGLYRDEETLEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 495037632 161 AAPEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:PRK00129 162 AAPEGIKALEEAHPDVEIYTAAIDEKLNEHGYIVPGLGDAGDRLFGTK 209
upp TIGR01091
uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees ...
 2-208 4.74e-123

uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273438  Cd Length: 207  Bit Score: 346.54  E-value: 4.74e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632    2 KIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAGL 81
Cdd:TIGR01091   1 MVVVVDHPLIKHKLTLLRDKNTDTKEFRELLRELGRLLAYEATRDLELEEVEVETPLGETEGGRILGKKIVLVPILRAGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   82 GMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVA 161
Cdd:TIGR01091  81 GMVDGVLKLIPEAKVGHVGAYRNEETLKPVPYYSKLPEDIDERTVIVLDPMLATGGTMIAALDLLKKRGPKKIKVLSIVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 495037632  162 APEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:TIGR01091 161 APEGIEAVEKAHPDVDIYTAAIDEKLNDNGYIVPGLGDAGDRAFGTK 207
Upp COG0035
Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil ...
 2-208 1.05e-122

Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439805  Cd Length: 209  Bit Score: 345.52  E-value: 1.05e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   2 KIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKGKKITVVPILRAGL 81
Cdd:COG0035    3 RVHVVDHPLIQHKLTLLRDKNTDTKEFRRLLEELGRLLAYEATRDLPLEEVEVETPLGKTTGKVLAGKKLVIVPILRAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  82 GMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVA 161
Cdd:COG0035   83 GMLDGVLDLLPSARVGHIGLYRDEETLEPVEYYFKLPEDLEGRTVIVLDPMLATGGSLVAAIDLLKKRGAKDIKIVCLIA 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 495037632 162 APEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGTK 208
Cdd:COG0035  163 APEGIERVQEAHPDVDIYTAAIDEELNEKGYIVPGLGDAGDRLFGTK 209
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 7-207 1.56e-85

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 251.26  E-value: 1.56e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632    7 KHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLLTEKVTIEGWNGPVEIEQIKG-KKITVVPILRAGLGMME 85
Cdd:pfam14681   1 DHPLLKHLLTILRDKSTSGPDFRFASDRIGRLLAYEALRDLPTEEVTVETPLGTTYAGVLFDeKKICGVPILRAGEGMED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   86 GVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKKAGCT--SIKVLVLVAAP 163
Cdd:pfam14681  81 GLRDLLPGARVGHIGIQRDEETLQPVEYYNKLPKDISDRTVILLDPMLATGGSAIAAIQVLREHGVPeeNIVVLSVIAAP 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 495037632  164 EGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGT 207
Cdd:pfam14681 161 EGLHRLAAAFPDVKIVTAAVDEELNENGYIVPGLGDAGDRLFGT 204
PLN02541 PLN02541
uracil phosphoribosyltransferase
 8-207 3.22e-56

uracil phosphoribosyltransferase


Pssm-ID: 215297  Cd Length: 244  Bit Score: 178.44  E-value: 3.22e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   8 HPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATAD-LLTEKVTIEGWNGPVEIEQIK-GKKITVVPILRAGLGMME 85
Cdd:PLN02541  39 HPLIKHWLSVLRNEQTPPPIFRSAMAELGRLLIYEASRDwLPTMTGEVQTPMGVADVEFIDpREPVAVVPILRAGLVLLE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  86 GVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIDE-RMALVVDPMLATGGSMIATIDLLKKAGCTS--IKVLVLVAA 162
Cdd:PLN02541 119 HASSVLPATKTYHLGFVRDEETLQPSMYLNKLPDKFPEgSRVLVVDPMLATGGTIVAAIDELVSRGASVeqIRVVCAVAA 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 495037632 163 PEGIKALEKAHPDIELYTASIDKGLNEHGYIIPGLGDAGDKIFGT 207
Cdd:PLN02541 199 PPALKKLSEKFPGLHVYAGIIDEEVNEKGYIVPGLGDAGDRSFGT 243
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 62-183 8.75e-20

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 81.29  E-value: 8.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  62 EIEQIKGKKITVVPILRAGLGMMEGVLE--NVPSARISVVGVYRDEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSM 139
Cdd:cd06223    8 EIREDLLEPDVVVGILRGGLPLAAALARalGLPLAFIRKERKGPGRTPSEPYGLELPLGGDVKGKRVLLVDDVIATGGTL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 495037632 140 IATIDLLKKAGCTSIKVLVLVAAPEGiKALEKAHPDIELYTASI 183
Cdd:cd06223   88 LAAIELLKEAGAKVVGVAVLLDKPEG-GARELASPGDPVYSLFT 130
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 63-171 7.24e-11

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 58.15  E-value: 7.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632   63 IEQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLvSNIDERMALVVDPMLATGGSMIAT 142
Cdd:pfam00156  23 NEDYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMKTSSAL-PDLKGKTVLIVDDILDTGGTLLKV 101

                          90       100
                  ....*....|....*....|....*....
gi 495037632  143 IDLLKKAGCTSIKVLVLVAAPEGIKALEK 171
Cdd:pfam00156 102 LELLKNVGPKEVKIAVLIDKPAGTEPKDK 130
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 119-207 1.15e-04

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 42.25  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632 119 SNIDERMALVVDPMLATGGSMIATIDLLKKAGCTsiKVLVLVAAP---EGIKALEKAHpdielytasidkglnEHGYIip 195
Cdd:PRK06827 260 RDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAK--KIIVAATFGfftNGLEKFDKAY---------------EEGYF-- 320

                         90
                 ....*....|..
gi 495037632 196 glgdagDKIFGT 207
Cdd:PRK06827 321 ------DRIIGT 326
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
124-171 1.85e-04

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 40.83  E-value: 1.85e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 495037632 124 RMALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVAAPEGIKALEK 171
Cdd:COG1926  122 RTVILVDDGIATGATMRAALRALRRQGPARIVVAVPVAPPDTLEELRR 169
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 127-170 1.95e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 40.44  E-value: 1.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 495037632 127 LVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVAAPE--GIKALE 170
Cdd:PRK02304 118 LIVDDLLATGGTLEAAIKLLERLGAEVVGAAFVIELPDlgGREKLE 163
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 127-173 2.26e-04

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 40.06  E-value: 2.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 495037632 127 LVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLV--AAPEGIKALEKAH 173
Cdd:COG0503  116 LIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIelGFLGGREKLRDYP 164
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 127-195 7.83e-04

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 38.98  E-value: 7.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495037632 127 LVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVA-APEGIKALEKAhpDIELYT-ASID---KGLNEHGYIIP 195
Cdd:COG0461  116 LVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDrEEGAAENLEEA--GVPLHSlLTLDdllELLKEKGYIDP 187
PRK06031 PRK06031
phosphoribosyltransferase; Provisional
 29-162 1.17e-03

phosphoribosyltransferase; Provisional


Pssm-ID: 235678  Cd Length: 233  Bit Score: 38.58  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495037632  29 RELASEV---GSLLTYEATADLLTEKVtiegwnGPVEIEQIKGkkitvVPILraGLGMMEGVLENVPSARISVVGVYR-- 103
Cdd:PRK06031  54 RALASLIvnqASFEVLDALAEHLAEKA------RAFDPDVVAG-----LPTL--GLTLAAAVARKLGHTRYVPLGTSRkf 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495037632 104 --DEETLEPV-----PYFQKLVSnIDERMA--------LVVDPMLATGGSMIATIDLLKKAGctsIKVLVLVAA 162
Cdd:PRK06031 121 wyRDELSVPLssittPDQGKRLY-IDPRMLpllegrrvALIDDVISSGASIVAGLRLLAACG---IEPAGIGAA 190
PLN02293 PLN02293
adenine phosphoribosyltransferase
 126-180 5.78e-03

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 36.19  E-value: 5.78e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495037632 126 ALVVDPMLATGGSMIATIDLLKKAGCTSIKVLVLVAAPEgIKALEKAHpDIELYT 180
Cdd:PLN02293 128 ALVIDDLIATGGTLCAAINLLERAGAEVVECACVIELPE-LKGREKLN-GKPLFV 180
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
118-166 5.98e-03

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 36.85  E-value: 5.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 495037632 118 VSNIDERMALVVDPMLATGGSMIATIDLLKKAGCTSikvlVLVAAPEGI 166
Cdd:PRK03092 196 VGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKD----VIIAATHGV 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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