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Conserved domains on  [gi|495054616|ref|WP_007779452|]
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MULTISPECIES: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Cronobacter]

Protein Classification

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase( domain architecture ID 11478026)

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of glycerone phosphate and sn-glycerol-3-phosphate

EC:  1.1.1.94
Gene Ontology:  GO:0051287|GO:0047952|GO:0009331|GO:0046167
SCOP:  4000111

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-330 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


:

Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 547.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   6 ASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPS 85
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  86 HVFGQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLHCGkSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAG 245
Cdd:PRK00094 162 RVQELFHSP-YFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 246 LGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREAAL 325
Cdd:PRK00094 241 LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDPREAVE 320


                 ....*
gi 495054616 326 TLLGR 330
Cdd:PRK00094 321 DLMGR 325
 
Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-330 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 547.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   6 ASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPS 85
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  86 HVFGQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLHCGkSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAG 245
Cdd:PRK00094 162 RVQELFHSP-YFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 246 LGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREAAL 325
Cdd:PRK00094 241 LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDPREAVE 320


                 ....*
gi 495054616 326 TLLGR 330
Cdd:PRK00094 321 DLMGR 325
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-333 0e+00

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 522.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   6 ASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPS 85
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  86 HVFGQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAG 245
Cdd:COG0240  161 RLQELLST-PYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 246 LGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREAAL 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ....*...
gi 495054616 326 TLLGRTRK 333
Cdd:COG0240  320 ALMARPLK 327
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 184-323 2.42e-77

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 233.43  E-value: 2.42e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  184 DFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAGLGDLVLTCTDNQSRNRRF 263
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  264 GMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREA 323
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEA 140
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-317 6.44e-58

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 190.63  E-value: 6.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616    7 SMTVIGAGSYGTALAITLARNG--------HHVVLW-------GHDPAHIatLQADRCNVAFLPDVPFPDTLHLESDLAT 71
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWvfeeeieGRNLTEI--INTTHENVKYLPGIKLPANLVAVPDLVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   72 AlAASRNILV-VVPSHVFGQVLRQIKPLMRPDARVVWATKGLE--AETGRLLQDVAREALGdeIPLAVISGPTFAKELAA 148
Cdd:TIGR03376  79 A-AKGADILVfVIPHQFLEGICKQLKGHVKPNARAISCIKGLEvsKDGVKLLSDIIEEELG--IPCGVLSGANLANEVAK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  149 GLPTAISLAATDETFADD----LQQLLHcGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLA 224
Cdd:TIGR03376 156 EKFSETTVGYRDPADFDVdarvLKALFH-RPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  225 EMSRLGAALG--ADPTTFMGMAGLGDLVLTCTDnqSRNRRFGMMLGQ-GADVQSAQEKI--GQVVEGYRNTKEVRELAAR 299
Cdd:TIGR03376 235 EMIKFARMFFptGEVTFTFESCGVADLITTCLG--GRNFKVGRAFAKtGKSLEELEKELlnGQSLQGVATAKEVHELLKN 312

                         330       340
                  ....*....|....*....|
gi 495054616  300 VGV--EMPITEEIYQVLYCG 317
Cdd:TIGR03376 313 KNKddEFPLFEAVYQILYEG 332
 
Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-330 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 547.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   6 ASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPS 85
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  86 HVFGQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLHCGkSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAG 245
Cdd:PRK00094 162 RVQELFHSP-YFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 246 LGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREAAL 325
Cdd:PRK00094 241 LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDPREAVE 320


                 ....*
gi 495054616 326 TLLGR 330
Cdd:PRK00094 321 DLMGR 325
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-333 0e+00

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 522.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   6 ASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPS 85
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  86 HVFGQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAG 245
Cdd:COG0240  161 RLQELLST-PYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 246 LGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREAAL 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ....*...
gi 495054616 326 TLLGRTRK 333
Cdd:COG0240  320 ALMARPLK 327
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-335 1.23e-82

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 253.64  E-value: 1.23e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   2 NTINASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILV 81
Cdd:PRK14618   1 MHHGMRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAERENREYLPGVALPAELYPTADPEEALAGADFAVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  82 VVPShvfgQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDE 161
Cdd:PRK14618  81 AVPS----KALRETLAGLPRALGYVSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAATVVASPEP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 162 TFADDLQQLLhCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFM 241
Cdd:PRK14618 157 GLARRVQAAF-SGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAEEATFY 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 242 GMAGLGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKiGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAR 321
Cdd:PRK14618 236 GLSGLGDLIATATSPHSRNRAAGEAIVRGVDREHLEAG-GKVVEGLYTVKALDAWAKAHGHDLPIVEAVARVARGGWDPL 314

                        330
                 ....*....|....
gi 495054616 322 EAALTLLGRTRKDE 335
Cdd:PRK14618 315 AGLRSLMGREAKEE 328
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 10-335 1.31e-80

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 248.93  E-value: 1.31e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  10 VIGAGSYGTALAITLARNGHhVVLWGHDPAHIATLQADRCNVAFLP-DVPFPDTLHLESDLATALAASRNILVVVPSHVF 88
Cdd:PRK12439  12 VLGGGSWGTTVASICARRGP-TLQWVRSAETADDINDNHRNSRYLGnDVVLSDTLRATTDFAEAANCADVVVMGVPSHGF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  89 GQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEiPLAVISGPTFAKELAAGLPTAISLAATDETFADDLQ 168
Cdd:PRK12439  91 RGVLTELAKELRPWVPVVSLVKGLEQGTNMRMSQIIEEVLPGH-PAGILAGPNIAREVAEGYAAAAVLAMPDQHLATRLS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 169 QLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAGLGD 248
Cdd:PRK12439 170 PLFRT-RRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKLGVAMGGNPETFAGLAGMGD 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 249 LVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREAALTLL 328
Cdd:PRK12439 249 LIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVVMEFADEYGLNMPIAREVDAVINHGSTVEQAYRGLI 328


                 ....*..
gi 495054616 329 GRTRKDE 335
Cdd:PRK12439 329 AEVPGHE 335
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 7-335 6.24e-80

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 246.05  E-value: 6.24e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   7 SMTVIGAGSYGTALAITLARNGHHVVLWGHdpahiatlqadrcnvaflpdvpfpdtlHLESDLATALAASRNILVVVPSH 86
Cdd:PRK14619   6 TIAILGAGAWGSTLAGLASANGHRVRVWSR---------------------------RSGLSLAAVLADADVIVSAVSMK 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  87 VFGQVLRQIKPL-MRPDARVVWATKGLEAETGRLLQDVAREALGDEiPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:PRK14619  59 GVRPVAEQVQALnLPPETIIVTATKGLDPETTRTPSQIWQAAFPNH-PVVVLSGPNLSKEIQQGLPAATVVASRDLAAAE 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLhCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAG 245
Cdd:PRK14619 138 TVQQIF-SSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTHLGAQTETFYGLSG 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 246 LGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLyCGKNAREAAL 325
Cdd:PRK14619 217 LGDLLATCTSPLSRNYQVGYGLAQGKSLEQILAELEGTAEGVNTANVLVQLAQQQNIAVPITEQVYRLL-QGEITPQQAL 295

                        330
                 ....*....|.
gi 495054616 326 T-LLGRTRKDE 335
Cdd:PRK14619 296 EeLMERDLKPE 306
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 184-323 2.42e-77

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 233.43  E-value: 2.42e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  184 DFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPTTFMGMAGLGDLVLTCTDNQSRNRRF 263
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  264 GMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLYCGKNAREA 323
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEA 140
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-164 1.04e-70

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 217.06  E-value: 1.04e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616    7 SMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSH 86
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKGADIIVIVVPSQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495054616   87 VFGQVLRQIKPLMRPDARVVWATKGLEAETGRLLQDVAREALGDEIPLAVISGPTFAKELAAGLPTAISLAATDETFA 164
Cdd:pfam01210  81 ALREVLKQLKGLLKPDAILVSLSKGIEPGTLKLLSEVIEEELGIQPPIAVLSGPSHAEEVAQGLPTATVIASKDEEAA 158
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 8-315 8.74e-69

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 218.16  E-value: 8.74e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   8 MTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAFLPDVPFPDTLHLESDLATALAASRN-ILVVVPSH 86
Cdd:PRK14620   3 ISILGAGSFGTAIAIALSSKKISVNLWGRNHTTFESINTKRKNLKYLPTCHLPDNISVKSAIDEVLSDNATcIILAVPTQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  87 VFGQVLRQIKPL-MRPDARVVWATKGLEAETGRLLQDVAREALGDEiPLAVISGPTFAKELAAGLPTAISLAATDETFAD 165
Cdd:PRK14620  83 QLRTICQQLQDChLKKNTPILICSKGIEKSSLKFPSEIVNEILPNN-PIAILSGPSFAKEIAEKLPCSIVLAGQNETLGS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 166 DLQQLLHcGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAA--LGADPTTFMGM 243
Cdd:PRK14620 162 SLISKLS-NENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLYSAknGSIDLNTLIGP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495054616 244 AGLGDLVLTCTDNQSRNRRFGMMLGQGADVQSAQEKIGQVVEGYRNTKEVRELAARVGVEMPITEEIYQVLY 315
Cdd:PRK14620 241 SCLGDLILTCTTLHSRNMSFGFKIGNGFNINQILSEGKSVIEGFSTVKPLISLAKKLNIELPICESIYNLLY 312
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-317 6.44e-58

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 190.63  E-value: 6.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616    7 SMTVIGAGSYGTALAITLARNG--------HHVVLW-------GHDPAHIatLQADRCNVAFLPDVPFPDTLHLESDLAT 71
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWvfeeeieGRNLTEI--INTTHENVKYLPGIKLPANLVAVPDLVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   72 AlAASRNILV-VVPSHVFGQVLRQIKPLMRPDARVVWATKGLE--AETGRLLQDVAREALGdeIPLAVISGPTFAKELAA 148
Cdd:TIGR03376  79 A-AKGADILVfVIPHQFLEGICKQLKGHVKPNARAISCIKGLEvsKDGVKLLSDIIEEELG--IPCGVLSGANLANEVAK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  149 GLPTAISLAATDETFADD----LQQLLHcGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLA 224
Cdd:TIGR03376 156 EKFSETTVGYRDPADFDVdarvLKALFH-RPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  225 EMSRLGAALG--ADPTTFMGMAGLGDLVLTCTDnqSRNRRFGMMLGQ-GADVQSAQEKI--GQVVEGYRNTKEVRELAAR 299
Cdd:TIGR03376 235 EMIKFARMFFptGEVTFTFESCGVADLITTCLG--GRNFKVGRAFAKtGKSLEELEKELlnGQSLQGVATAKEVHELLKN 312

                         330       340
                  ....*....|....*....|
gi 495054616  300 VGV--EMPITEEIYQVLYCG 317
Cdd:TIGR03376 313 KNKddEFPLFEAVYQILYEG 332
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 9-322 7.14e-38

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 138.61  E-value: 7.14e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   9 TVIGAGSYGTALAITLARNGHH-------VVLW-------GHDPAHIatLQADRCNVAFLPDVPFPDTLHLESDLATALA 74
Cdd:PTZ00345  15 SVIGSGNWGSAISKVVGENTQRnyifhneVRMWvleeiveGEKLSDI--INTKHENVKYLPGIKLPDNIVAVSDLKEAVE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  75 ASRNILVVVPSHVFGQVLRQIKPL--MRPDARVVWATKGLEAETGR--LLQDVAREALGdeIPLAVISGPTFAKELAAGL 150
Cdd:PTZ00345  93 DADLLIFVIPHQFLESVLSQIKENnnLKKHARAISLTKGIIVENGKpvLCSDVIEEELG--IPCCALSGANVANDVAREE 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 151 PTAISLAATDETFADDLQQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLG 230
Cdd:PTZ00345 171 FSEATIGCEDKDDALIWQRLFDR-PYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLFG 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 231 AALGADPT--TFMGMAGLGDLVLTCTDnqSRNRR----FGMMLGQGADVQSAQEKI-GQVVEGYRNTKEVREL--AARVG 301
Cdd:PTZ00345 250 KIFFPNVMdeTFFESCGLADLITTCLG--GRNVRcaaeFAKRNGKKSWEEIEAELLnGQKLQGTVTLKEVYEVleSHDLK 327

                        330       340
                 ....*....|....*....|.
gi 495054616 302 VEMPITEEIYQVLYCGKNARE 322
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSS 348
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 244-310 8.58e-26

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 97.95  E-value: 8.58e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495054616  244 AGLGDLVLTCTDNQSRNRRFGMMLGQGadVQSAQEKIGQVVEGYRNTKEVRE-LAARVGVEMPITEEI 310
Cdd:pfam20618   1 AGLGDLVLTCTSDLSRNRTFGLLLGKG--MTLAEAGNGQVAEGVRTAKAVAAiLARAHNVEMPILEAV 66
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 9-142 1.87e-07

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 49.92  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616    9 TVIGAGSYGTALAITLARNGHHVVLWGHDPAHIA------TLQADRCNVAFLPDVPFPDTLHLESdlatalaaSRNILVV 82
Cdd:pfam02558   2 AILGAGAIGSLLGARLAKAGHDVTLILRGAELAAikknglRLTSPGGERIVPPPAVTSASESLGP--------IDLVIVT 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   83 VPSHVFGQVLRQIKPLMRPDARVVWATKGLEAEtgrllqDVAREALGDEiplAVISGPTF 142
Cdd:pfam02558  74 VKAYQTEEALEDIAPLLGPNTVVLLLQNGLGHE------EVLREAVPRE---RVLGGVTT 124
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 9-314 9.98e-07

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 49.47  E-value: 9.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   9 TVIGAGSYGTALAITLARNGHHVVLWGHdPAHIATLQADRCNVAFLPDVPFPDTLHLESDLAtALAASRNILVVVPSHVF 88
Cdd:COG1893    4 AILGAGAIGGLLGARLARAGHDVTLVAR-GAHAEALRENGLRLESPDGDRTTVPVPAVTDPE-ELGPADLVLVAVKAYDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  89 GQVLRQIKPLMRPDARVVWATKGLEAEtgrllqDVAREALGDEiplAVISGPTF--AKELAAGL-----PTAISLAATDE 161
Cdd:COG1893   82 EAAAEALAPLLGPDTVVLSLQNGLGHE------ERLAEALGAE---RVLGGVVTigATREEPGVvrhtgGGRLVLGELDG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 162 TFADDLQQLL----HCGksFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANART----ALITRGLAEMSRLGAAL 233
Cdd:COG1893  153 GPSERLEALAelleAAG--IPVEVSDDIRGALWEKLLLNAAINPLTALTGAPNGELLADpearALARALMREVLAVARAE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616 234 GADPTTfmgmAGLGDLVLTCTDNQSRNRrfGMMLgqgADVQSaqekiGQVVE-GYRNtKEVRELAARVGVEMPITEEIYQ 312
Cdd:COG1893  231 GVPLPE----DDLEERVAAVAEATADNR--SSML---QDLEA-----GRPTEiDAIN-GAVVRLARRLGVPTPVNEALYA 295


                 ..
gi 495054616 313 VL 314
Cdd:COG1893  296 LL 297
PRK08229 PRK08229
2-dehydropantoate 2-reductase; Provisional
 5-135 2.38e-05

2-dehydropantoate 2-reductase; Provisional


Pssm-ID: 236193 [Multi-domain]  Cd Length: 341  Bit Score: 45.38  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   5 NASMTVIGAGSYGTALAITLARNGHHVVLWGHDP------AHIATLQADRCNVAFLPdvpfPDTLHLESDLAtALAASRN 78
Cdd:PRK08229   2 MARICVLGAGSIGCYLGGRLAAAGADVTLIGRARigdelrAHGLTLTDYRGRDVRVP----PSAIAFSTDPA-ALATADL 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 495054616  79 ILVVVPSHVFGQVLRQIKPLMRPDARVVWATKGLEAEtgrllqDVAREALGDEIPLA 135
Cdd:PRK08229  77 VLVTVKSAATADAAAALAGHARPGAVVVSFQNGVRNA------DVLRAALPGATVLA 127
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
9-148 3.04e-05

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 45.40  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   9 TVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRcnvaflpdVPF--P------------DTLHLESDLATALA 74
Cdd:COG1004    4 AVIGTGYVGLVTAACLAELGHEVTCVDIDEEKIEALNAGE--------IPIyePgleelvarnvaaGRLRFTTDLAEAVA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  75 ASRNILVVVP-----------SHVFgQVLRQIKPLMRPDARVVwaTK-----GleaeTGRLLQDVAREAL-GDEIPLAVI 137
Cdd:COG1004   76 EADVVFIAVGtpsdedgsadlSYVL-AAARSIGEALKGYKVVV--TKstvpvG----TADRVRAIIAEELrGAGVDFDVV 148

                        170
                 ....*....|.
gi 495054616 138 SGPTFAKELAA 148
Cdd:COG1004  149 SNPEFLREGSA 159
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 9-106 4.41e-05

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 44.46  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   9 TVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNV----AFLPDVPFPDTLHL-ESDLatalaasrnILVVV 83
Cdd:PRK06522   4 AILGAGAIGGLFGAALAQAGHDVTLVARRGAHLDALNENGLRLedgeITVPVLAADDPAELgPQDL---------VILAV 74

                         90       100
                 ....*....|....*....|...
gi 495054616  84 PSHVFGQVLRQIKPLMRPDARVV 106
Cdd:PRK06522  75 KAYQLPAALPSLAPLLGPDTPVL 97
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 10-106 6.61e-05

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 44.03  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  10 VIGAGSYGTALAITLARNGHHVV-LWGHDPAHIATLqadrcnVAFLPDVPFPDTLHL--ESDLatalaasrnILVVVPSH 86
Cdd:COG5495    8 IIGAGRVGTALAAALRAAGHEVVgVYSRSPASAERA------AALLGAVPALDLEELaaEADL---------VLLAVPDD 72

                         90       100
                 ....*....|....*....|..
gi 495054616  87 VFGQVLRQIK--PLMRPDARVV 106
Cdd:COG5495   73 AIAEVAAGLAaaGALRPGQLVV 94
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 6-47 1.72e-04

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 42.72  E-value: 1.72e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 495054616   6 ASMTVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQAD 47
Cdd:PRK06129   3 GSVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAY 44
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 10-106 5.51e-04

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 40.82  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  10 VIGAGSYGTALAITLARNG---HHVVLWGHDPAHIATLqADRCNVaflpdvpfpdtlHLESDLATALAASRNILVVVPSH 86
Cdd:COG0345    7 FIGAGNMGSAIIKGLLKSGvppEDIIVSDRSPERLEAL-AERYGV------------RVTTDNAEAAAQADVVVLAVKPQ 73

                         90       100
                 ....*....|....*....|
gi 495054616  87 VFGQVLRQIKPLMRPDARVV 106
Cdd:COG0345   74 DLAEVLEELAPLLDPDKLVI 93
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 9-106 7.17e-04

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 41.06  E-value: 7.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616    9 TVIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNV------AFLPDVPFPDTLHLESDLATALAASRNILVV 82
Cdd:TIGR03026   4 AVIGLGYVGLPLAALLADLGHDVTGVDIDQEKVDKLNKGKSPIyepgldELLAKALKAGRLRATTDYEEAIRDADVIIIC 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 495054616   83 VP-----------SHVFgQVLRQIKPLMRPDARVV 106
Cdd:TIGR03026  84 VPtplkedgspdlSYVE-SAAETIAKHLRKGATVV 117
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
 7-102 9.37e-04

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 40.74  E-value: 9.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   7 SMTVIGA-GSYGTALAITLARNGHHVVLWGHDPaHIATLQADRCNVAFLPDvpfpdtlhlesdlATALAASRNILVV-VP 84
Cdd:PRK08655   2 KISIIGGtGGLGKWFARFLKEKGFEVIVTGRDP-KKGKEVAKELGVEYAND-------------NIDAAKDADIVIIsVP 67

                         90
                 ....*....|....*...
gi 495054616  85 SHVFGQVLRQIKPLMRPD 102
Cdd:PRK08655  68 INVTEDVIKEVAPHVKEG 85
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
10-102 2.30e-03

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 39.35  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616  10 VIGAGSYGTALAITLARNGHHVVLWGHDPAHIATLQADRCNVAflpdvpfpDTLhleSDLATALAASRNILVVVPS-HVF 88
Cdd:PRK09599   5 MIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEGATGA--------DSL---EELVAKLPAPRVVWLMVPAgEIT 73

                         90
                 ....*....|....
gi 495054616  89 GQVLRQIKPLMRPD 102
Cdd:PRK09599  74 DATIDELAPLLSPG 87
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 9-105 4.76e-03

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 38.18  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054616   9 TVIGAGSYGTALAITLARNG--HHVVLWGHDPAHIAtlQADRCNVAflpDvpfpdtlHLESDLATALAASRNILVVVPSH 86
Cdd:COG0287    5 AIIGLGLIGGSLALALKRAGlaHEVVGVDRSPETLE--RALELGVI---D-------RAATDLEEAVADADLVVLAVPVG 72

                         90
                 ....*....|....*....
gi 495054616  87 VFGQVLRQIKPLMRPDARV 105
Cdd:COG0287   73 ATIEVLAELAPHLKPGAIV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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