|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
31-408 |
1.80e-46 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 165.52 E-value: 1.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 31 YFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWFNVFafMLIIGGIILDKM-GVRFTGMGACLLMVLGcglkyyaiSTT 109
Cdd:cd17340 12 YFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVV--LCFFGGFLIDRVfGIRLGTIIFSLLVLIG--------QLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 110 FAEGSTLlgmkTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLALAVTVPIATFFgit 189
Cdd:cd17340 82 FALGALT----NLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGSTVNFNVMPPIYKRI--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 190 DDEGVFHPNIPAPLLLCLTMLCIGTIAFFIYTFYDKKLDASLEEEGAEPEEPFRMKDIwlIVTNKGFWLIALLCVLFYSA 269
Cdd:cd17340 155 SDFYSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKESNKTGEVIKLSDV--KDFPLSFWLICIICVFYYVA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 270 VFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVHTMFALPILNVWWFa 349
Cdd:cd17340 233 VFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVGRNILWVLIALVITLLGHLLLAFTFVNPLIA- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 495117401 350 tiiMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLNE 408
Cdd:cd17340 312 ---MVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDK 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-451 |
2.01e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 160.05 E-value: 2.01e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 16 RWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWfnVFAFMLIIGGIILDKMGVRFTGMGACLLM 95
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVL--VGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 96 VLGCGLKYYAISttfaegstllgmktqVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLA 175
Cdd:COG2223 81 GIGLLLLALAVS---------------YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 176 LAVTVPIATFFGITddegvfhpnipAPLLLCLTMLCIGTIAFFIYTFYDKKLDASLEEEgaepeepfRMKDIWLIVTNKG 255
Cdd:COG2223 146 AFLAPLLIAAFGWR-----------NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA--------SLRDQLEALRDPR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 256 FWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVh 335
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 336 TMFALPILNVWWFaTIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLNeyckgpvv 415
Cdd:COG2223 286 LLLALALGSLWLF-LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD-------- 356
|
410 420 430
....*....|....*....|....*....|....*.
gi 495117401 416 dgmQTYDYTLPMWIFAGFGVAALFFALWLKGENKKK 451
Cdd:COG2223 357 ---ATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-450 |
4.01e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 117.28 E-value: 4.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 13 KALRWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWfnVFAFMLIIGGIILDKMGVRFTGMGAC 92
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFL--GYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 93 LLMVLGCGLkyYAISTTFAegstllgmktqvgMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGT 172
Cdd:COG2271 83 LLWGLATLL--FGFATSFW-------------QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 173 MLALAVTVPIATFFGITddegvfhpnipaplllcLTMLCIGTIAFfiytfydkkldasleeegaepeepfrmkdIWLIVT 252
Cdd:COG2271 148 ALAPPLLGWLLAAFGWR-----------------AAFLILGLPGL-----------------------------LLALLR 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 253 nkgFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLI 332
Cdd:COG2271 182 ---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 333 FVhTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLneyckg 412
Cdd:COG2271 259 AL-ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL------ 331
|
410 420 430
....*....|....*....|....*....|....*...
gi 495117401 413 pvvdgmQTYDYTLPMWIFAGFGVAALFFALWLKGENKK 450
Cdd:COG2271 332 ------DATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-442 |
1.67e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 1.67e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 23 VAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWFNvfAFMLIIGGIILDKMGVRFTGMGACLLMVLGCGLK 102
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGY--ALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 103 YYAISttfaegstllgmktqVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLALAVTVPI 182
Cdd:cd06174 79 AFAPS---------------FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 183 ATFFGITDdegvfhpnipapLLLCLTMLCIGTIAFFIYTFYDKKLDASLEEEGAEPEEPFRMKDIWLIVTNKGFWLIALL 262
Cdd:cd06174 144 ASSLGFGW------------RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 263 CVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVhtMFALPI 342
Cdd:cd06174 212 IFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG--LALLLL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 343 LNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLNeyckgpvvdgmQTYD 422
Cdd:cd06174 290 APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA-----------ATFG 358
|
410 420
....*....|....*....|
gi 495117401 423 YTLPMWIFAGFGVAALFFAL 442
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-388 |
1.56e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.57 E-value: 1.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 10 NDSKALRWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWfnVFAFMLIIGGIILDKMGVRFTGM 89
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLL--GAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 90 GACLLMVLGCGLkyYAISTTFaegstllgmktqvGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATAR 169
Cdd:COG2814 80 LGLLLFALGSLL--CALAPSL-------------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 170 LGTMLALAVTVPIATFFGItddegvfhpniPAPLLLCLTMLCIGTIAFFIYtfydkkLDASLEEEGAEPEEPFRMkdiwl 249
Cdd:COG2814 145 LGPALGPLLGGLLADLFGW-----------RWVFLVNAVLALLALLLLLRL------LPESRPAARARLRGSLRE----- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 250 IVTNKGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIgsv 329
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG--- 279
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 495117401 330 LLIFVHTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIF 388
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-394 |
4.78e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 4.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 20 LALVAFTMLCGYFLTDVMSPlkPMLEKELLWDSLDYGIFTSAYGWFnvFAFMLIIGGIILDKMGVRFTGMGACLLMVLGC 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALP--LLLAEDLGISPTEIGLLLTLFSLG--YALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 100 glkyyaisttfaegsTLLGMKTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLALAVT 179
Cdd:pfam07690 77 ---------------LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 180 VPIATFFGItddegvfhpniPAPLLLCLTMLCIGTIAFFIYTfydkKLDASLEEEGAEPEEPFRMKDIWLIVTNKGFWLI 259
Cdd:pfam07690 142 GLLASLFGW-----------RAAFLILAILSLLAAVLLLLPR----PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 260 ALLCVLFYSAVFPFlkYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVHTMFA 339
Cdd:pfam07690 207 LALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 495117401 340 LPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWG 394
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-445 |
8.59e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 75.69 E-value: 8.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 20 LALVAFTMLCGYFltdVMSPLKPMLEKELLWDSLDYGIFTSAYGWFNVFafMLIIGGIILDKMGVRftgmgacLLMVLGC 99
Cdd:cd17325 1 LSLALFLDMLGYG---IIIPILPLYAESLGASVAQIGLIVAAYALAQLL--FSPPAGRLSDRFGRK-------RLLLLGL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 100 GLkyYAISTTfaegstLLGMKTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLALAVT 179
Cdd:cd17325 69 LL--LAVSTL------LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 180 VPIATFFGItddegvfhpniPAPLLLCLTMLCIGTIAFFIYtfydkKLDASLEEEGAEPEEPFRMKDIWLIVTNKGFWLI 259
Cdd:cd17325 141 GLLADALGY-----------RAPFLVCAALALLALVLALLL-----LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLAL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 260 ALLCVLFY---SAVFPFLKYatdLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKgaTLMIIGSVLLIFVhT 336
Cdd:cd17325 205 FLAIFVLAfafGALEPFLPL---YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR--KPLILIGLLLSAV-A 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 337 MFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVlneyckgpvvd 416
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL----------- 347
|
410 420
....*....|....*....|....*....
gi 495117401 417 gMQTYDYTLPMWIFAGFGVAALFFALWLK 445
Cdd:cd17325 348 -YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-442 |
4.02e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 73.37 E-value: 4.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 16 RWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWFnvFAFMLIIGGIILDKMGVRfTGMGACLLm 95
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLG--YALFQVPGGWLLDRFGAR-KVLAVSML- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 96 vlgcglkyyaistTFAEGSTLLGMKTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLA 175
Cdd:cd17319 77 -------------LWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 176 LAVTVPIATFFGItddEGVFhpnipapLLLCLTMLCIGTIAFFIYtfydkkldasleeegaepeepfrmkdiwlivtnKG 255
Cdd:cd17319 144 PPLSGWLLLLFGW---RWAF-------IIEGLLGLLLAVLWWFYL---------------------------------RQ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 256 FWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVH 335
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 336 TMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLNeyckgpvv 415
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD-------- 332
|
410 420
....*....|....*....|....*..
gi 495117401 416 dgmQTYDYTLPMWIFAGFGVAALFFAL 442
Cdd:cd17319 333 ---ATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
16-444 |
1.10e-13 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 72.26 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 16 RWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDygIFTSAYGWFNVFAFMLIIGGIILDKMGVRFTGMGACLLM 95
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLAS--VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 96 VLGCGLKYYAISTTfaegstllgmktqvgMAALGYAIF-GVGVEIAGITVSKIIVKWFKGKeMALAMGMEMATARLGTML 174
Cdd:cd17353 79 GLGFILSAFAISLP---------------LLFLGYGVLgGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 175 AlavTVPIATFFGITDDEGVFhpnipapLLLCLTMLCIGTIAFFIYTF-YDKKLDASLEEEGAEPEEPFRMKDIWLIVTN 253
Cdd:cd17353 143 F---SPLIAYLINTVGVPTTF-------LILGIIFLIIIVIGAFLIRDpPKGWVPPGVDPLANNAENSPRDYTPREMLRT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 254 KGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIF 333
Cdd:cd17353 213 PTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 334 VHTMFALPILNVWWFATIIMIILGIG--FSLVPSAmwpsVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLneyck 411
Cdd:cd17353 293 MFLLPFIGSVAVLFVLGVALIGFCYGggFALFPAL----TADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVL----- 363
|
410 420 430
....*....|....*....|....*....|...
gi 495117401 412 gpvvdgmQTYDYTLPMWIFAGFGVAALFFALWL 444
Cdd:cd17353 364 -------YTGGYNAAFIIAAALSLVALALALLL 389
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-444 |
1.18e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.21 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 1 MKEQIQKKLNDSKALRWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWfnVFAFMLIIGGIILD 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLL--AFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 81 KMGVRFTGMGACLLMVLGCGLKYYAisttfaegstllgmkTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFkGKEMALA 160
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLA---------------PSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLM 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 161 MGMEMATARLGTMLALAVTVPIATFFGItddegvfhpnipAPLLLCLTMLCIGTIAFFIYTFYDKKLDASLEEEGAEPEE 240
Cdd:COG2807 143 TGLYTAAMGLGAALAAGLTVPLAAALGW------------RGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 241 PFRMKDIWLIvtnkgfWLIALLCVLFYSAVFPFL-KYATDLmvqkyNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGK 319
Cdd:COG2807 211 LWRSPLAWLL------TLFFGLQSLLYYAVVAWLpPILRDA-----GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 320 GATLMIIGSVLLIFVHTMFALPILNVWWFATIIM-IILGIGFSLVPSAMWPSVPkiiPEKQLGTAYALIFWVQNWGLMGV 398
Cdd:COG2807 280 RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLgLGQGGLFPLALTLIGLRAR---TPAEAAALSGMAQSVGYLLAALG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 495117401 399 PALIGFVLNeyckgpvvdgmQTYDYTLPMWIFAGFGVAALFFALWL 444
Cdd:COG2807 357 PLLVGALHD-----------ATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
155-441 |
2.01e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.61 E-value: 2.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 155 KEMALAMGMEMATARLGTMLALAVTVPIATFFGITDDEGVFhpnipaplLLCLTMLCIGTIAFFIYTFYDKKLDASLEEE 234
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYR--------LTALIFAVLGLLAFLLTFFGTKERPVPEEEK 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 235 GAEPeepfrmKDIWLIVTNKGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVY 314
Cdd:COG2211 215 VSLK------ESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 315 DRIGKGATLMIIGSVLLIFVHTMFALPILNVWWFAtIIMIILGIGFSLVPSAMWPSVPKIIPEKQL-------GTAYALI 387
Cdd:COG2211 289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL-VLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIF 367
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 495117401 388 FWVQNWGLMGVPALIGFVLNEYckGPVVDGMQTYDYTLPMWIFAGFGVAALFFA 441
Cdd:COG2211 368 TFAIKLGQALAGALAGLLLALF--GYVAGAAQSPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
257-462 |
1.05e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.85 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 257 WLIALLCVLFYSAVFPFLkyaTDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKgATLMIIGSVLLIFVht 336
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFM---AIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 337 MFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLNeyckgpvvd 416
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL--------- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 495117401 417 gmqtYDYTLPMWIFAGFGVAALFFALWLKGENKKKGYGLEEPNIKK 462
Cdd:cd17329 150 ----YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR 191
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-386 |
8.70e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.11 E-value: 8.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 20 LALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYgwFNVFAFMLIIGGIILDKMGVRFTGMGACLLMVLGC 99
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAF--TLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 100 GLkyYAISTTFAEgstllgmktqvgmAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLALAvt 179
Cdd:cd17474 79 LL--CGLSDSFAL-------------LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPL-- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 180 vpIATFFGITDDEGVFhpnipapLLLCLTMLcigtIAFFIYTFYDKKLDASLEEEGAEPEEPFRmkdiwLIVTNKGFWLI 259
Cdd:cd17474 142 --LGGLLAAISWRYPF-------FLLAALIP----VAFLAILFLLPEPKEKAKSSSATKLRDLK-----KALRGRGLLTF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 260 ALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVhtMFA 339
Cdd:cd17474 204 LVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS--LLL 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 495117401 340 LPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYAL 386
Cdd:cd17474 282 LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
69-442 |
1.47e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.40 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 69 AFMLIIGGIILDKMGVRftgmgacllMVLGCGlkyyaistTFAEGSTLLGMKTQVGMAALGYAIFGVGVEIAGITV--SK 146
Cdd:cd17475 45 AVSMLPAGWLLDRFGER---------RVLAVG--------LLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPggGR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 147 IIVKWFKGKEMALAMGMEMATARLGTMLALAVTVPIATFFGitddegvfhpnIPAPLLLCLTMLCIGTIAFFIytFYDKK 226
Cdd:cd17475 108 AIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-----------WRAAFVVAGLVSILAAVLFWL--FYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 227 LDASLEEEGAEPeepfRMKDIWLIVTNKGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFL 306
Cdd:cd17475 175 PAASAATESAST----LLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 307 TPLFGNVYDRIGKG---ATLMIIGSVLLIFVHTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTA 383
Cdd:cd17475 251 RIGLGRVSDRVFGGrrrPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTA 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 495117401 384 YALIFWVQNWGLMGVPALIGFVLNeyckgpvvdgmQTYDYTLPMWIFAGFGVAALFFAL 442
Cdd:cd17475 331 LGLANTINFIGIAIGPPLFGLLVD-----------ATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
56-442 |
1.81e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.94 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 56 GIFTSAYGWfnVFAFMLIIGGIILDKMGVRFTGMGACLLMVLGCglkyyaISTTFAEGSTLLgMKTQVGMAALGYAIFGV 135
Cdd:cd17324 37 GLLVSAYAL--GYALGALLLGPLSDRIERRRLLLVLLLLFILGN------LLAALAPSFALL-LLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 136 GVEIAGITVSKiivkwfkgKEMALAMGMEMAtarlGTMLALAVTVPIATFFG-ITDDEGVFhpnipapllLCLTMLCIGT 214
Cdd:cd17324 108 AAAYAADLVPP--------EKRGRAIGLVFS----GLTLGLVLGRPLGGLLGqLLGWRAAF---------LAIAVLALLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 215 IAFFIYTFYDKKLDASLEEEGAepeepfrmKDIWLIVTNKGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGT 294
Cdd:cd17324 167 ALLLWRLLPSLPPKKPGSLGLL--------SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 295 IPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIfvhTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKI 374
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA---LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495117401 375 IPEKQlGTAYALIFWVQNWGLMGVPALIGFVLneyckgpvvdgmQTYDYTLPMWIFAGFGVAALFFAL 442
Cdd:cd17324 316 APEAR-GLASSLYLAAYNLGGALGAALGGLVL------------DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-444 |
5.00e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 5.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 256 FWLIALLCVLFYSAVFPFLkyatDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIigsVLLIFVH 335
Cdd:COG2814 15 LALGAFLSGLGIGIVLPAL----PLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL---GLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 336 TMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLneyckgpvv 415
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA--------- 158
|
170 180
....*....|....*....|....*....
gi 495117401 416 dgmQTYDYTLPMWIFAGFGVAALFFALWL 444
Cdd:COG2814 159 ---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-451 |
1.71e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 12 SKALRWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWfnVFAFMLIIGGIILDKMGVRFTGMGA 91
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFL--GYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 92 CLLMVLGCGLkyYAISTTFaegstllgmktqvGMAALGYAIFGVGVEIAGITVSKIIVkwfkgkemalAMGMEMATARLG 171
Cdd:COG0738 80 LLLMALGLLL--FALAPSY-------------PLLLLALFLLGLGLGLLDVAANPYVA----------ALGPETAASRLN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 172 TMLAL----AVTVPIATFFGITDDegvFHPNIPAPLLLCLTMLCIGTIAFFIYTFYD-KKLDASLEEEGAEPEEPFRMKD 246
Cdd:COG0738 135 LLHAFfslgALLGPLLGGLLILLG---LSLSWHLPYLILAVLLLLLALLFLRSKLPEiEEEEEEAAGSAASLKSLLKNPR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 247 IWLIVtnkgfwLIALLCVLFYSAVFPFLkyaTDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMII 326
Cdd:COG0738 212 LLLGG------LAIFLYVGAEGAIGDWL---PLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 327 GSVLLIFvhtMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQlGTAYALIFWVQNWGLMGVPALIGFVl 406
Cdd:COG0738 283 ALLAAVG---LLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFL- 357
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 495117401 407 neyckgpvvdgMQTYDYTLPMWIFAGFGVAALFFALWLKGENKKK 451
Cdd:COG0738 358 -----------ADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
165-375 |
1.13e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.60 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 165 MATARLGTMLALAVTVPIATFFGITDDEGVFhpnipapLLLCLTMLCIGTIAFFIYTFYDKKLDASLEEEGAEPEEpfrM 244
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGY-------FLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL---L 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 245 KDIWLIVTNKGFWLIALLCVLFYSAVFpfLKYATDLMVQKYNVDPELAGT-IPSLLPLGTLFLTPLFGNVYDRIGKgATL 323
Cdd:cd17332 212 KSLKALLKNRPFLILLLAYLLYFLAFN--IVNTVLVYYFKYVLGGRAELVlLLLLILSGALLALLPWPPLKKRFGK-KKA 288
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 495117401 324 MIIGSVLLIFVHTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKII 375
Cdd:cd17332 289 FFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
280-452 |
1.23e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 280 LMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKgATLMIIGsvLLIFVHTMFALPILNVWWFATIIMIILGIG 359
Cdd:cd17489 21 LYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGR-KRLLLIG--LLIFALATLLYLLATSVALLLVLRLIHGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 360 FSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVlneyckgpvvdgMQTYDYTLPMWIFAGFGVAALF 439
Cdd:cd17489 98 WGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL------------YQHLGFAVLFIVAAVLALLALL 165
|
170
....*....|...
gi 495117401 440 FALWLKGENKKKG 452
Cdd:cd17489 166 LVFLVKDPPPVAA 178
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
256-442 |
2.11e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 256 FWLIALLCVLFYSAVFPFLKYatdLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIgsvLLIFVH 335
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPL---LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 336 TMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLneyckgpvv 415
Cdd:pfam07690 75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------- 145
|
170 180
....*....|....*....|....*..
gi 495117401 416 dgmQTYDYTLPMWIFAGFGVAALFFAL 442
Cdd:pfam07690 146 ---SLFGWRAAFLILAILSLLAAVLLL 169
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
251-444 |
2.20e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 251 VTNKGFWLIALLCVLFYSAVFPF---LKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIg 327
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDrsnLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 328 svLLIFVHTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVln 407
Cdd:COG2271 82 --LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-- 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 495117401 408 eyckgpvvdgMQTYDYTLPMWIFAGFGVAALFFALWL 444
Cdd:COG2271 158 ----------LAAFGWRAAFLILGLPGLLLALLRFWL 184
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
265-449 |
6.75e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.88 E-value: 6.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 265 LFYSAVFPFLKYATDLMVQKyNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIFVHTMFALPILN 344
Cdd:cd17335 8 FFFAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 345 VWWFAtIIMIILGIGFSLVPSAMWPSVPKIIPEKQLgtayalifwvqNWGLMGVPALIGFVLNEYCKGPVVDGMQTY-DY 423
Cdd:cd17335 87 FWLLL-LLVILGAFFSAPVVPLVDSITLQYLGEERE-----------RYGKQRLWGSIGFGIAALLVGILIDRSSTYkNY 154
|
170 180
....*....|....*....|....*.
gi 495117401 424 TLPMWIFAGFGVAALFFALWLKGENK 449
Cdd:cd17335 155 TIAFYVFAVLMLLALLLALKFPFRPK 180
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-408 |
7.03e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 7.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 20 LALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYgwFNVFAFMLIIGGIILDKMGVRftgmgacLLMVLGC 99
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAY--LLGFALGQLLYGPLSDRFGRR-------PVLLAGL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 100 GLkyyaisttFAEGSTLLGMKTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLGTMLALAVT 179
Cdd:cd17320 72 LL--------FILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 180 VPIATFFGItddEGVFhpnipaplllcLTMLCIGTIAFFIYTFYDKKldaSLEEEGAEPEEPFRMKDIWLIVTNKGFWLI 259
Cdd:cd17320 144 GLLLLFFGW---RAIF-----------VFLALLGLLLLLLVLLFLPE---TLPEEKRKPLLSSLLRAYKRVLKNRRFLGY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 260 ALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGK------GATLMIIGSVLLIF 333
Cdd:cd17320 207 ALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPrrllrlGLLLLLAAALVLLL 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495117401 334 VHTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIpekqlGTAYALIFWVQNWGLMGVPALIGFVLNE 408
Cdd:cd17320 287 AALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA-----GTASALLGFLQFLIGALAGALVGLLPNG 356
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
254-404 |
9.62e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 9.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 254 KGFWLIALLCVLFYSAvFPFLKYatdlMVQKYNVDPELagtIPSL--LPLGTLFLT-PLFGNVYDRIGKGaTLMIIGSVL 330
Cdd:cd17370 203 WLYLLAVALFALGNFS-FAFLIL----RAQELGLSAAL---IPLLyaLFNLVYALAaYPAGRLSDRIGRK-KLLILGYLS 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495117401 331 LIFVHTMFALPIlnVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGF 404
Cdd:cd17370 274 LALAYLGFALGS--SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGY 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
276-443 |
1.43e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 276 YATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYD----RIGKGATLMIIGSVLL-IFVHTMFALPILNVW---W 347
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLaLSFVLLFTAPDLSPTgklI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 348 FATIIMIILGIGFSLVPSAMWPSVPKIIPE-KQLGTAYALIFWVQNWGLMGVPALIGFVLNeyckgpVVDGMQTYDYTLP 426
Cdd:COG2211 112 YALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVA------AFGGDAALGYRLT 185
|
170
....*....|....*..
gi 495117401 427 MWIFAGFGVAALFFALW 443
Cdd:COG2211 186 ALIFAVLGLLAFLLTFF 202
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
254-445 |
1.74e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.70 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 254 KGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGaTLMIIGSVLLIF 333
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR-LVLVAGLLLTAV 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 334 -VHTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLNEYCKG 412
Cdd:cd17321 247 gLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSA 326
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 495117401 413 PVVDGMQTYD-----------YTLPMWIFAGFGVAALFFALWLK 445
Cdd:cd17321 327 NLGDSGVAALlsaaaaafaagFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
254-442 |
4.26e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 254 KGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLLIF 333
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 334 VHTMFALPILNVWWfatiiMIILGIGFSLVPSAMWPSVPKIIPE----KQLGTAYALIFWVQNWGLMGVPALIGFVLNey 409
Cdd:cd17316 257 ALPLFYLLSGSPTL-----LLLLLFILSFFVGGVWGALYAYLAElfptEVRATGVGLSYNLGRLGGGGAPPLIALLLA-- 329
|
170 180 190
....*....|....*....|....*....|...
gi 495117401 410 ckgpvvdgmQTYDYTLPMWIFAGFGVAALFFAL 442
Cdd:cd17316 330 ---------STGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
252-444 |
1.71e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.61 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 252 TNKGFWLIALLCVLFYSAVFPFLKYATDLMvQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVLL 331
Cdd:cd17352 181 KDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLI 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 332 IFVhTMFALPILNVWWFATIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIfwvqnWGLMGVPALIGFVLNeyck 411
Cdd:cd17352 260 LGL-SLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLV-----LLFQGLAALVGPPIA---- 329
|
170 180 190
....*....|....*....|....*....|...
gi 495117401 412 GPVVDGMQTYDYTLpmwIFAGFGVAALFFALWL 444
Cdd:cd17352 330 GLLRDYTGDYDAAF---YFCGACLLLSGVLLFL 359
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
258-365 |
1.90e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 40.28 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 258 LIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVL----LIF 333
Cdd:cd17385 204 LLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVIGSIItgvgFLL 283
|
90 100 110
....*....|....*....|....*....|....
gi 495117401 334 VHTMFALPILNVWWFATIIMIILG--IGFSLVPS 365
Cdd:cd17385 284 LGPAPLLPIKSELWMVIIGLVLLGlsLGAALVPT 317
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
242-443 |
2.29e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 242 FRMKDIWLIVTNKGFWLIALLCVLFYSAVFPFLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGA 321
Cdd:cd17341 193 EFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRR 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 322 TLMIIGSVLLIFVHTMFALPILNVWWFATII------MIILGIGFSLVPsAMWPSvpkiIPEKQLGTAYALIFWVQNWGL 395
Cdd:cd17341 273 RLWWLFIVMTIGAALLSLSLPTSGTNLVLFLalfvalGLGAGAGNGSVF-RMVPF----IFRRELGAVTGLVGAIGGLGG 347
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 495117401 396 MGVPALIGFVLNeyckgpvvdgmQTYDYTLPMWIFAGFGVAALFFALW 443
Cdd:cd17341 348 FFLPLLFGSSAL-----------MTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
301-445 |
5.24e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 5.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 301 LGTLFLTPLFGNVYDRIGkGATLMIIGSVLLIFVHTMFALPILNVWWFAtIIMIILGIGFSLVPSAMWPSVPKIIPEKQL 380
Cdd:cd17504 228 LVMLIAGPLAGRLIARVG-PRRVLLIGLVISAVGLLLLALLHSSLWALV-VALLLIGIGLGLAFASLPNIVVESVPPDRT 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495117401 381 GTAYALIFWVQNWGLMGVPALIGFVLNEYCKGPVVDGMQTYD-YTLPMWIFAGFGVAALFFALWLK 445
Cdd:cd17504 306 GIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGaYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
273-445 |
6.03e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 273 FLKYATDLMVQKYNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLM---IIGSVLLIFVHTMFALPILNVWWFA 349
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLIladLLRALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 350 tIIMIILGIGFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPALIGFVLneyckgpvvdgmQTYDYTLPMWI 429
Cdd:cd06173 97 -VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV------------ALLGPGGAFAI 163
|
170
....*....|....*.
gi 495117401 430 FAGFGVAALFFALWLK 445
Cdd:cd06173 164 NALSFLLSALLLLFIR 179
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
257-354 |
7.58e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 38.38 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 257 WLIALLCVLFYSAVFPFLKYATDLMVQKyNVDPELAGTIPSLLPLGTLFLTPLFGNVYDRIGKGATLMIIGSVL--LIFV 334
Cdd:pfam12832 2 WRLKGFYFFYFAALGCLLPYWGLYLRSI-GLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILaaVLFL 80
|
90 100
....*....|....*....|
gi 495117401 335 HTMFALPILNVWWFATIIMI 354
Cdd:pfam12832 81 SVLFIPISLTFWWLALLVVL 100
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-187 |
7.67e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 7.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 12 SKALRWSVLALVAFTMLCGYFLTDVMSPLKPMLEKELLWDSLDYGIFTSAYGWfnVFAFMLIIGGIILDKMGVRFTGMGA 91
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLL--GRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495117401 92 CLLMVLGcglkyyaisttfaegSTLLGMKTQVGMAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGMEMATARLG 171
Cdd:COG0477 86 LLLFGLA---------------SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLG 150
|
170
....*....|....*.
gi 495117401 172 TMLALAVTVPIATFFG 187
Cdd:COG0477 151 LALGPLLGGLLVAALG 166
|
|
| |
