|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11061 |
PRK11061 |
phosphoenolpyruvate--protein phosphotransferase; |
1-747 |
0e+00 |
|
phosphoenolpyruvate--protein phosphotransferase;
Pssm-ID: 182937 [Multi-domain] Cd Length: 748 Bit Score: 1541.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 1 MLTRLREIVEKVASAPRLNEALDILVTDICLAMDTDVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80
Cdd:PRK11061 1 MLTRLREIVEKVASAPRLNEALDILVTETCLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 81 LAEPINLADAQKHPSFKYIPSVREERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQLT 160
Cdd:PRK11061 81 LAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIYRRQLLGVLVVQQRELRQFDESEESFLVTLATQLAAILSQSQLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 161 ALFGQYRQTRIRALPASPGVAIAPGWMDATLPLMEQVYEASTLDTGLERERLTTALEEAAGEFRRYSKRFAAGAQKETAA 240
Cdd:PRK11061 161 ALFGQYRQTRIRALPASPGVAIAEGWQDATQPLLEQVYPASTLDPALERERLTGALEEAANEFRRYSKRFAAGAQKETAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 241 IFDLYSHLLSDARLRRELYEEVDKGSVAEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHLDDNIQSPNTWP 320
Cdd:PRK11061 241 IFDLYSHLLNDPRLRRELFAEVDKGSVAEWAVKQVIEKFAEQFAALSDNYLRERAGDLRALGQRLLFHLDDSEQGPNAWP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 321 ERFVLVADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHHRMLVVDGYRGELLVDPSPV 400
Cdd:PRK11061 321 ERFILVADELTATLLAELPQDRLAGVVVRDGAANSHAAILVRALGIPTVMGADIQPSLLHQRLLIVDGYRGELLVDPEPV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 401 LLHEYQRLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQV 480
Cdd:PRK11061 401 LLQEYQRLISEEIELSRLAEDDVNLPAQLKSGERIKVMLNAGLSAEHEEKLGSRVDGVGLYRTEIPFMLQSGFPSEEEQV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 481 AQYQGMLQMFNDKPVTLRTLDVGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMIT 560
Cdd:PRK11061 481 AQYQGMLQMFPDKPVTLRTLDIGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMVT 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 561 SIDEVDEARRLIDRAGREMEEMLGYEIPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLY 640
Cdd:PRK11061 561 SIDEVDEARRLIDRAGREVEEMLGYEIPKPRIGIMIEVPSMVFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLY 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 641 DSLHPAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEEAETLSARSLE 720
Cdd:PRK11061 641 DSLHPAMLRALKMIADEAEQHGLPVSLCGEMAGDPMGALLLIGLGYRHLSMNGRSVARVKYLLRHIDLAEAENLAQRSLE 720
|
730 740
....*....|....*....|....*..
gi 495127080 721 SQSATEVRHQVAAFMERRGMGGLIRGG 747
Cdd:PRK11061 721 AQLATEVRHQVAAFMERRGLGGLIRGG 747
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
171-738 |
0e+00 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 592.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 171 IRALPASPGVAIAPG-WMDATLPLMEQvYEASTLDTGLERERLTTALEEAAGEFRRYSKRFAAGAQKETAAIFDLYSHLL 249
Cdd:COG1080 1 LKGIAASPGIAIGKAfLLREEDLEVPE-YTISPEDVEAEIARLEAALAKAREELEALREKAPEDLGEEEAAIFDAHLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 250 SDARLRRELYEEVDKGSV-AEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHL-DDNIQSPNTWPERFVLVA 327
Cdd:COG1080 80 EDPELIEEVEELIREGRYnAEWALKEVIEELAAQFEALDDEYLRERAADIRDVGRRVLRNLlGVEAPDLSDLPEPVILVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 328 DELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGA-DIQPSVLHHRMLVVDGYRGELLVDPSPVLLHEYQ 406
Cdd:COG1080 160 HDLTPSDTAQLDPSRVAGFVTDLGGRTSHTAILARSLGIPAVVGLgDALLLVKDGDLVIVDGDAGVVIVNPDEETLAEYR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 407 RLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGM 486
Cdd:COG1080 240 ERQAEYAAERAELARLRDLPAVTLDGVRVELAANIGLPEDAAAALENGAEGVGLFRTEFLFMDRDDLPTEEEQFEAYRAV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 487 LQMFNDKPVTLRTLDVGADKQLPYMPIS-EENPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGNLSILLPMITSIDEV 565
Cdd:COG1080 320 AEAMGGRPVTIRTLDIGGDKPLPYLPLPkEENPFLGLRAIRLCLDRPELFRTQLRAILRA-SAHGNLRIMFPMISSVEEL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 566 DEARRLIDRAGREMEEMlGYEI-PKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLYDSLH 644
Cdd:COG1080 399 RQAKALLEEAKAELRAE-GIPFdEDIPVGIMIEVPAAALIADQLAKEVDFFSIGTNDLIQYTLAVDRGNEKVAYLYDPLH 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 645 PAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEEAETLSARSLESQSA 724
Cdd:COG1080 478 PAVLRLIKMVIDAAHKAGKPVGVCGEMAGDPLATPLLLGLGLDELSMSPSSIPAVKAIIRRLDLAEARALAEKALALDTA 557
|
570
....*....|....
gi 495127080 725 TEVRHQVAAFMERR 738
Cdd:COG1080 558 EEVRALLEEFLAEL 571
|
|
| PEP-utilizers_C |
pfam02896 |
PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at ... |
419-706 |
1.23e-133 |
|
PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at the C terminus of a number of PEP (phosphoenolpyruvate)-utilizing proteins. In PPDK (Pyruvate phosphate dikinase) this C-terminal domain has been shown to be a PEP-binding domain.
Pssm-ID: 397163 [Multi-domain] Cd Length: 292 Bit Score: 397.06 E-value: 1.23e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 419 AEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGMLQMFNDKPVTLR 498
Cdd:pfam02896 4 LGKLKDLPAPTADGTKIKVAANIGTPDDAEAALANGAEGIGLYRTEFLFMDRDELPTEDEQFEAYKGVLEAMNGRPVTVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 499 TLDVGADKQLPYMPISEE-NPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGNLSILLPMITSIDEVDEARRLIDRAGR 577
Cdd:pfam02896 84 TLDIGGDKELPYLEEPEEmNPFLGWRGIRIGLDRPELFRTQLRAILRA-SAFGNLRIMFPMVASVEELREAKAIIEEVKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 578 EMEEMLGYeIPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLYDSLHPAMLRALKMIALE 657
Cdd:pfam02896 163 ELDAEVGF-DKDIKVGIMIEVPSAALLADQLAKEVDFFSIGTNDLTQYTLAVDRDNERVAYLYDPLHPAVLRLIKEVIRA 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495127080 658 AQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHI 706
Cdd:pfam02896 242 AHRHGKWVGICGEMAGDPSAVPLLVGLGLDEFSMSPDSVPRARALLAQI 290
|
|
| PTS_I_fam |
TIGR01417 |
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of ... |
171-728 |
7.17e-119 |
|
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of phophoenolpyruvate (PEP)-dependent enzymes. Most members are known or deduced to function as the phosphoenolpyruvate-protein phosphotransferase (or enzyme I) of PTS sugar transport systems. However, some species with both a member of this family and a homolog of the phosphocarrier protein HPr lack a IIC component able to serve as a permease. An HPr homolog designated NPr has been implicated in the regulation of nitrogen assimilation, which demonstrates that not all phosphotransferase system components are associated directly with PTS transport.
Pssm-ID: 273611 [Multi-domain] Cd Length: 565 Bit Score: 368.74 E-value: 7.17e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 171 IRALPASPGVAIAPGWM--DATLPLMEQVYEASTLDTglERERLTTALEEAAGEFRRYSKRFAAGAQKETAAIFDLYSHL 248
Cdd:TIGR01417 1 ISGIGVSPGIAIGKALLlkKPDLVIDRKKISASQVDQ--EISRFLSARAKAKEDLETIKTKAGKTFGQEKAAIFEAHILI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 249 LSDARLRRELYEEVDKGSV-AEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHL-DDNIQSPNTWPERFVLV 326
Cdd:TIGR01417 79 LEDPELTEEVIELIKKDHKnAEFAAHEVFEGQAKSLEEMDDEYLKERAADIRDIGNRLLGHLlGVKISDLSEIQDEVILV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 327 ADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMG-ADIQPSVLHHRMLVVDGYRGELLVDPSPVLLHEY 405
Cdd:TIGR01417 159 AEDLTPSETAQLNLKYVKGFLTDAGGKTSHTAIMARSLEIPAIVGtKSVTSQVKNGDTVIIDGVKGIVIFNPSSETIDKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 406 QRLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQG 485
Cdd:TIGR01417 239 EAKQEAVSSEKAELAKLKDKPAITLDGHQVELAANIGTVDDVEGAERNGGEGIGLFRTEFLYMSRDQLPTEEEQFAAYKT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 486 MLQMFNDKPVTLRTLDVGADKQLPYMPI-SEENPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGNLSILLPMITSIDE 564
Cdd:TIGR01417 319 VLEAMESDAVIVRTLDIGGDKELPYLNFpKEENPFLGYRAIRLALEREEILRTQLRAILRA-SAYGKLRIMFPMVATVEE 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 565 VDEARRLIDRAGREMEEMLGYEIPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLYDSLH 644
Cdd:TIGR01417 398 IRAVKQELEEEKQELNDEGKAFDENIEVGVMIEIPSAALIADHLAKEVDFFSIGTNDLTQYTLAVDRGNDLISNLYQPYN 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 645 PAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEEAETLSARSLESQSA 724
Cdd:TIGR01417 478 PAVLRLIKLVIDAAKAEGIWVGMCGEMAGDERAIPLLLGLGLRELSMSASSILRIKMIIRKLNIEECKSLAEKALAQPTT 557
|
....
gi 495127080 725 TEVR 728
Cdd:TIGR01417 558 EEVH 561
|
|
| GAF |
smart00065 |
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ... |
17-159 |
1.87e-23 |
|
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.
Pssm-ID: 214500 [Multi-domain] Cd Length: 149 Bit Score: 97.07 E-value: 1.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 17 RLNEALDILVTDICLAMDTDVCSVYLADHD-RRCYYLMATRGLKKPRGRtVTLAFDEGIVGLVGRLAEPINLADAQKHPS 95
Cdd:smart00065 1 DLEELLQTILEELRQLLGADRVLIYLVDENdRGELVLVAADGLTLPTLG-IRFPLDEGLAGRVAETGRPLNIPDVEADPL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495127080 96 FKYIPSVREERFRAFLGVPIIQRRQLLGVLVVQQREL-RQYDESEESFLVTLATQMAAILSQSQL 159
Cdd:smart00065 80 FAEDLLGRYQGVRSFLAVPLVADGELVGVLALHNKKSpRPFTEEDEELLQALANQLAIALANAQL 144
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11061 |
PRK11061 |
phosphoenolpyruvate--protein phosphotransferase; |
1-747 |
0e+00 |
|
phosphoenolpyruvate--protein phosphotransferase;
Pssm-ID: 182937 [Multi-domain] Cd Length: 748 Bit Score: 1541.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 1 MLTRLREIVEKVASAPRLNEALDILVTDICLAMDTDVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80
Cdd:PRK11061 1 MLTRLREIVEKVASAPRLNEALDILVTETCLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 81 LAEPINLADAQKHPSFKYIPSVREERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQLT 160
Cdd:PRK11061 81 LAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIYRRQLLGVLVVQQRELRQFDESEESFLVTLATQLAAILSQSQLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 161 ALFGQYRQTRIRALPASPGVAIAPGWMDATLPLMEQVYEASTLDTGLERERLTTALEEAAGEFRRYSKRFAAGAQKETAA 240
Cdd:PRK11061 161 ALFGQYRQTRIRALPASPGVAIAEGWQDATQPLLEQVYPASTLDPALERERLTGALEEAANEFRRYSKRFAAGAQKETAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 241 IFDLYSHLLSDARLRRELYEEVDKGSVAEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHLDDNIQSPNTWP 320
Cdd:PRK11061 241 IFDLYSHLLNDPRLRRELFAEVDKGSVAEWAVKQVIEKFAEQFAALSDNYLRERAGDLRALGQRLLFHLDDSEQGPNAWP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 321 ERFVLVADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHHRMLVVDGYRGELLVDPSPV 400
Cdd:PRK11061 321 ERFILVADELTATLLAELPQDRLAGVVVRDGAANSHAAILVRALGIPTVMGADIQPSLLHQRLLIVDGYRGELLVDPEPV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 401 LLHEYQRLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQV 480
Cdd:PRK11061 401 LLQEYQRLISEEIELSRLAEDDVNLPAQLKSGERIKVMLNAGLSAEHEEKLGSRVDGVGLYRTEIPFMLQSGFPSEEEQV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 481 AQYQGMLQMFNDKPVTLRTLDVGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMIT 560
Cdd:PRK11061 481 AQYQGMLQMFPDKPVTLRTLDIGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMVT 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 561 SIDEVDEARRLIDRAGREMEEMLGYEIPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLY 640
Cdd:PRK11061 561 SIDEVDEARRLIDRAGREVEEMLGYEIPKPRIGIMIEVPSMVFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLY 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 641 DSLHPAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEEAETLSARSLE 720
Cdd:PRK11061 641 DSLHPAMLRALKMIADEAEQHGLPVSLCGEMAGDPMGALLLIGLGYRHLSMNGRSVARVKYLLRHIDLAEAENLAQRSLE 720
|
730 740
....*....|....*....|....*..
gi 495127080 721 SQSATEVRHQVAAFMERRGMGGLIRGG 747
Cdd:PRK11061 721 AQLATEVRHQVAAFMERRGLGGLIRGG 747
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
171-738 |
0e+00 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 592.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 171 IRALPASPGVAIAPG-WMDATLPLMEQvYEASTLDTGLERERLTTALEEAAGEFRRYSKRFAAGAQKETAAIFDLYSHLL 249
Cdd:COG1080 1 LKGIAASPGIAIGKAfLLREEDLEVPE-YTISPEDVEAEIARLEAALAKAREELEALREKAPEDLGEEEAAIFDAHLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 250 SDARLRRELYEEVDKGSV-AEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHL-DDNIQSPNTWPERFVLVA 327
Cdd:COG1080 80 EDPELIEEVEELIREGRYnAEWALKEVIEELAAQFEALDDEYLRERAADIRDVGRRVLRNLlGVEAPDLSDLPEPVILVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 328 DELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGA-DIQPSVLHHRMLVVDGYRGELLVDPSPVLLHEYQ 406
Cdd:COG1080 160 HDLTPSDTAQLDPSRVAGFVTDLGGRTSHTAILARSLGIPAVVGLgDALLLVKDGDLVIVDGDAGVVIVNPDEETLAEYR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 407 RLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGM 486
Cdd:COG1080 240 ERQAEYAAERAELARLRDLPAVTLDGVRVELAANIGLPEDAAAALENGAEGVGLFRTEFLFMDRDDLPTEEEQFEAYRAV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 487 LQMFNDKPVTLRTLDVGADKQLPYMPIS-EENPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGNLSILLPMITSIDEV 565
Cdd:COG1080 320 AEAMGGRPVTIRTLDIGGDKPLPYLPLPkEENPFLGLRAIRLCLDRPELFRTQLRAILRA-SAHGNLRIMFPMISSVEEL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 566 DEARRLIDRAGREMEEMlGYEI-PKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLYDSLH 644
Cdd:COG1080 399 RQAKALLEEAKAELRAE-GIPFdEDIPVGIMIEVPAAALIADQLAKEVDFFSIGTNDLIQYTLAVDRGNEKVAYLYDPLH 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 645 PAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEEAETLSARSLESQSA 724
Cdd:COG1080 478 PAVLRLIKMVIDAAHKAGKPVGVCGEMAGDPLATPLLLGLGLDELSMSPSSIPAVKAIIRRLDLAEARALAEKALALDTA 557
|
570
....*....|....
gi 495127080 725 TEVRHQVAAFMERR 738
Cdd:COG1080 558 EEVRALLEEFLAEL 571
|
|
| PEP-utilizers_C |
pfam02896 |
PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at ... |
419-706 |
1.23e-133 |
|
PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at the C terminus of a number of PEP (phosphoenolpyruvate)-utilizing proteins. In PPDK (Pyruvate phosphate dikinase) this C-terminal domain has been shown to be a PEP-binding domain.
Pssm-ID: 397163 [Multi-domain] Cd Length: 292 Bit Score: 397.06 E-value: 1.23e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 419 AEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGMLQMFNDKPVTLR 498
Cdd:pfam02896 4 LGKLKDLPAPTADGTKIKVAANIGTPDDAEAALANGAEGIGLYRTEFLFMDRDELPTEDEQFEAYKGVLEAMNGRPVTVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 499 TLDVGADKQLPYMPISEE-NPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGNLSILLPMITSIDEVDEARRLIDRAGR 577
Cdd:pfam02896 84 TLDIGGDKELPYLEEPEEmNPFLGWRGIRIGLDRPELFRTQLRAILRA-SAFGNLRIMFPMVASVEELREAKAIIEEVKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 578 EMEEMLGYeIPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLYDSLHPAMLRALKMIALE 657
Cdd:pfam02896 163 ELDAEVGF-DKDIKVGIMIEVPSAALLADQLAKEVDFFSIGTNDLTQYTLAVDRDNERVAYLYDPLHPAVLRLIKEVIRA 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495127080 658 AQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHI 706
Cdd:pfam02896 242 AHRHGKWVGICGEMAGDPSAVPLLVGLGLDEFSMSPDSVPRARALLAQI 290
|
|
| PTS_I_fam |
TIGR01417 |
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of ... |
171-728 |
7.17e-119 |
|
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of phophoenolpyruvate (PEP)-dependent enzymes. Most members are known or deduced to function as the phosphoenolpyruvate-protein phosphotransferase (or enzyme I) of PTS sugar transport systems. However, some species with both a member of this family and a homolog of the phosphocarrier protein HPr lack a IIC component able to serve as a permease. An HPr homolog designated NPr has been implicated in the regulation of nitrogen assimilation, which demonstrates that not all phosphotransferase system components are associated directly with PTS transport.
Pssm-ID: 273611 [Multi-domain] Cd Length: 565 Bit Score: 368.74 E-value: 7.17e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 171 IRALPASPGVAIAPGWM--DATLPLMEQVYEASTLDTglERERLTTALEEAAGEFRRYSKRFAAGAQKETAAIFDLYSHL 248
Cdd:TIGR01417 1 ISGIGVSPGIAIGKALLlkKPDLVIDRKKISASQVDQ--EISRFLSARAKAKEDLETIKTKAGKTFGQEKAAIFEAHILI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 249 LSDARLRRELYEEVDKGSV-AEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHL-DDNIQSPNTWPERFVLV 326
Cdd:TIGR01417 79 LEDPELTEEVIELIKKDHKnAEFAAHEVFEGQAKSLEEMDDEYLKERAADIRDIGNRLLGHLlGVKISDLSEIQDEVILV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 327 ADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMG-ADIQPSVLHHRMLVVDGYRGELLVDPSPVLLHEY 405
Cdd:TIGR01417 159 AEDLTPSETAQLNLKYVKGFLTDAGGKTSHTAIMARSLEIPAIVGtKSVTSQVKNGDTVIIDGVKGIVIFNPSSETIDKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 406 QRLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQG 485
Cdd:TIGR01417 239 EAKQEAVSSEKAELAKLKDKPAITLDGHQVELAANIGTVDDVEGAERNGGEGIGLFRTEFLYMSRDQLPTEEEQFAAYKT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 486 MLQMFNDKPVTLRTLDVGADKQLPYMPI-SEENPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGNLSILLPMITSIDE 564
Cdd:TIGR01417 319 VLEAMESDAVIVRTLDIGGDKELPYLNFpKEENPFLGYRAIRLALEREEILRTQLRAILRA-SAYGKLRIMFPMVATVEE 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 565 VDEARRLIDRAGREMEEMLGYEIPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVDRNNTRVASLYDSLH 644
Cdd:TIGR01417 398 IRAVKQELEEEKQELNDEGKAFDENIEVGVMIEIPSAALIADHLAKEVDFFSIGTNDLTQYTLAVDRGNDLISNLYQPYN 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 645 PAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEEAETLSARSLESQSA 724
Cdd:TIGR01417 478 PAVLRLIKLVIDAAKAEGIWVGMCGEMAGDERAIPLLLGLGLRELSMSASSILRIKMIIRKLNIEECKSLAEKALAQPTT 557
|
....
gi 495127080 725 TEVR 728
Cdd:TIGR01417 558 EEVH 561
|
|
| PRK11177 |
PRK11177 |
phosphoenolpyruvate-protein phosphotransferase PtsI; |
171-736 |
6.36e-112 |
|
phosphoenolpyruvate-protein phosphotransferase PtsI;
Pssm-ID: 183017 [Multi-domain] Cd Length: 575 Bit Score: 350.85 E-value: 6.36e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 171 IRALPASPGVAIApgwmdATLPLME-------QVYEASTLDTglERERLTTALEEAAGEFRRYSKRFAAGAQKETAAIFD 243
Cdd:PRK11177 2 ISGILASPGIAFG-----KALLLKEdeivinrKKISADQVDQ--EVERFLSGRAKASAQLEAIKTKAGETFGEEKEAIFE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 244 LYSHLLSDarlrRELYEEV-----DKGSVAEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFH-LDDNIQSPN 317
Cdd:PRK11177 75 GHIMLLED----EELEQEIialikDKHMTADAAAHSVIEGQAKALEELDDEYLKERAADVRDIGKRLLKNiLGLKIIDLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 318 TWPERFVLVADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGA-DIQPSVLHHRMLVVDGYRGELLVD 396
Cdd:PRK11177 151 AIQEEVILVAADLTPSETAQLNLKKVLGFITDIGGRTSHTSIMARSLELPAIVGTgNITKQVKNGDYLILDAVNNQIYVN 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 397 PSPVLLHEYQRL----LSEENELSRIAEdyveQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSG 472
Cdd:PRK11177 231 PTNEVIEELKAVqeqyASEKAELAKLKD----LPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDRDA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 473 FPSEEEQVAQYQGMLQMFNDKPVTLRTLDVGADKQLPYMPI-SEENPCLGWRGIRITLDQPEIFLIQVRAMLRAnAATGN 551
Cdd:PRK11177 307 LPTEEEQFQAYKAVAEAMGSQAVIVRTMDIGGDKELPYMNLpKEENPFLGWRAIRIAMDRKEILHDQLRAILRA-SAFGK 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 552 LSILLPMITSIDEVDEARRLIDRAGREM-EEMLGYEiPKPRLGIMVEVPSMLFMLPHLASRVDFISVGTNDLTQYLLAVD 630
Cdd:PRK11177 386 LRIMFPMIISVEEVRELKAEIEILKQELrDEGKAFD-ESIEIGVMVETPAAAVIARHLAKEVDFFSIGTNDLTQYTLAVD 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 631 RNNTRVASLYDSLHPAMLRALKMIALEAQRLGIDLCLCGEMAGDPMCVALLVGMGYHHLSMNGRSVARVKYLLRHITLEE 710
Cdd:PRK11177 465 RGNELISHLYNPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFED 544
|
570 580
....*....|....*....|....*.
gi 495127080 711 AETLSARSLESQSATEVRHQVAAFME 736
Cdd:PRK11177 545 AKALAEQALAQPTADELMTLVNKFIE 570
|
|
| PtsP |
COG3605 |
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; |
1-182 |
4.21e-68 |
|
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
Pssm-ID: 442824 [Multi-domain] Cd Length: 188 Bit Score: 222.08 E-value: 4.21e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 1 MLTRLREIVEKVASAPRLNEALDILVTDICLAMDTDVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80
Cdd:COG3605 2 MLKALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLLDPDGGRLELRATEGLNPEAVGKVRLPLGEGLVGLVAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 81 LAEPINLADAQKHPSFKYIPSVREERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQLT 160
Cdd:COG3605 82 RGEPLNLADAASHPRFKYFPETGEEGFRSFLGVPIIRRGRVLGVLVVQSREPREFTEEEVEFLVTLAAQLAEAIANAELL 161
|
170 180
....*....|....*....|....*.
gi 495127080 161 ALFGQYRQTRIRAL----PASPGVAI 182
Cdd:COG3605 162 GELRAALAELSLAReeerEAAVEAAI 187
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
345-699 |
2.19e-43 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 168.38 E-value: 2.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 345 GVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHHRMLV-VDGYRGELLVDPSPVLLHEYQRLLseenelsriAEDYV 423
Cdd:TIGR01418 406 AIVTNEGGMTCHAAIVARELGIPAVVGTGDATKTLKDGMEVtVDCAEGDTGYVYAGKLEHEVKEVE---------LSNMP 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 424 EQPaclksgerVQVMLNAGlSPEHEEKLGSR-IDGIGLYRTEipFMLQSG----------FPSEEEQVAQ---------- 482
Cdd:TIGR01418 477 VTA--------TKIYMNVG-NPEVAFRFAALpNDGVGLARIE--FIILNWigkhplalidDDDLESVEKNeieelmagnp 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 483 --------YQGMLQM---FNDKPVTLRTLDVGAD--KQL----PYMPIsEENPCLGWRGIRITLDQ--PEIFLIQVRAML 543
Cdd:TIGR01418 546 rdffvdklAEGIAKVaaaFYPKPVIVRTSDFKSNeyRNLiggeEYEPD-EENPMLGWRGASRYYSEsyEEAFRLECRAIK 624
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 544 RANAATG--NLSILLPMITSIDEVDEARRLIDRAGREMEEMlGYEIpkprlGIMVEVPSMLFMLPHLASRVDFISVGTND 621
Cdd:TIGR01418 625 RVREEMGltNVEVMIPFVRTPEEGKRALEIMAEEGLRRGKN-GLEV-----YVMCEVPSNALLADEFAKEFDGFSIGSND 698
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495127080 622 LTQYLLAVDRNNTRVASLYDSLHPAMLRALKMIALEAQRLGIDLCLCGEMAGD-PMCVALLVGMGYHHLSMNGRSVARV 699
Cdd:TIGR01418 699 LTQLTLGVDRDSGLVAHLFDERNPAVLRLIEMAIKAAKEHGKKVGICGQAPSDyPEVVEFLVEEGIDSISLNPDAVLRT 777
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
355-703 |
7.26e-41 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 160.68 E-value: 7.26e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 355 SHAAIMVRAMGIPTVMGADIQPSVLHHRMLV----VDGYRGellvdpspvllHEYQRLLseENELSRIAEDYVEQPAclk 430
Cdd:PRK06464 417 CHAAIIARELGIPAVVGTGNATEVLKDGQEVtvscAEGDTG-----------YVYEGLL--EFEVEEVSLEEMPETP--- 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 431 sgerVQVMLNAGlSPEHEEKLgSRI--DGIGLYRTEipFM----------------------------LQSGFPSEEE-- 478
Cdd:PRK06464 481 ----TKIMMNVG-NPERAFDF-AALpnDGVGLARLE--FIinnmigvhplallefdqqdadlkaeieeLTAGYASPEEfy 552
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 479 --QVAQYQGML-QMFNDKPVTLRTLD---------VGADKqlpYMPIsEENPCLGWRGIRITLDQP--EIFLIQVRAMLR 544
Cdd:PRK06464 553 vdKLAEGIATVaAAFYPKPVIVRLSDfksneyanlIGGER---YEPE-EENPMLGFRGASRYLSESfrEAFALECEAIKR 628
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 545 ANAATG--NLSILLPMITSideVDEARRLIDragrEMEEMlGYEIPKP--RLGIMVEVPSMLFMLPHLASRVDFISVGTN 620
Cdd:PRK06464 629 VREEMGltNVEVMIPFVRT---VEEAEKVIE----LLAEN-GLKRGENglKVIMMCEIPSNALLAEEFLEYFDGFSIGSN 700
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 621 DLTQYLLAVDRNNTRVASLYDSLHPAMLRALKMIALEAQRLGIDLCLCGEMAGD-PMCVALLVGMGYHHLSMNGRSVARV 699
Cdd:PRK06464 701 DLTQLTLGLDRDSGLVAHLFDERNPAVKKLISMAIKAAKKAGKYVGICGQAPSDhPDFAEWLVEEGIDSISLNPDAVVDT 780
|
....
gi 495127080 700 KYLL 703
Cdd:PRK06464 781 WLAV 784
|
|
| PEP-utilizers_N |
pfam05524 |
PEP-utilizing enzyme, N-terminal; |
172-294 |
9.45e-26 |
|
PEP-utilizing enzyme, N-terminal;
Pssm-ID: 461671 [Multi-domain] Cd Length: 125 Bit Score: 102.69 E-value: 9.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 172 RALPASPGVAIAPGW-MDATLPLMEQVYEASTLDTGLERERLTTALEEAAGEFRRYSKRFAAGAQKETAAIFDLYSHLLS 250
Cdd:pfam05524 1 KGIGASPGIAIGKAVvLEEPELEVPDEREVPADDVEAEIARLEAALEAAREELEALAERAAGELGEEEAAIFEAHLMMLE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 495127080 251 DARLRRELYEEVDKGSV-AEWAVKKVIEKFAEQFAALTDGYLKER 294
Cdd:pfam05524 81 DPELLEEVEELIREGGLnAEAAVKEVVDEFAAMFEAMDDPYLRER 125
|
|
| PRK11377 |
PRK11377 |
dihydroxyacetone kinase subunit M; Provisional |
151-372 |
1.26e-23 |
|
dihydroxyacetone kinase subunit M; Provisional
Pssm-ID: 183108 [Multi-domain] Cd Length: 473 Bit Score: 104.83 E-value: 1.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 151 AAILSQSQLTAL-FGQYRQTRIRALPASPGVAIAPGWMdaTLPLMEQVYEASTLDTGLERERLTTALEEAAGEFRRYSKR 229
Cdd:PRK11377 226 EALIAFRQLAEDnFGETEEVAPPTLRPVPSPVSGKAFY--YQPVLCTVQAKSTLTVEEEQERLRQAIDFTLLDLMTLTAK 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 230 FAAGAQKETAAIFDLYSHLLSDARLRRELYEEVDKGSV-AEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFH 308
Cdd:PRK11377 304 AEASGLDDIAAIFSGHHTLLDDPELLAAASERLQHEHCtAEYAWQQVLKELSQQYQQLDDEYLQARYIDVDDLLHRTLVH 383
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495127080 309 LDDNIQSPNTWPERFVLVADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGA 372
Cdd:PRK11377 384 LTQTKEELPQFNSPTILLAENIYPSTVLQLDPAVVKGICLSAGSPLSHSAIIARELGIGWICQQ 447
|
|
| GAF |
smart00065 |
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ... |
17-159 |
1.87e-23 |
|
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.
Pssm-ID: 214500 [Multi-domain] Cd Length: 149 Bit Score: 97.07 E-value: 1.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 17 RLNEALDILVTDICLAMDTDVCSVYLADHD-RRCYYLMATRGLKKPRGRtVTLAFDEGIVGLVGRLAEPINLADAQKHPS 95
Cdd:smart00065 1 DLEELLQTILEELRQLLGADRVLIYLVDENdRGELVLVAADGLTLPTLG-IRFPLDEGLAGRVAETGRPLNIPDVEADPL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495127080 96 FKYIPSVREERFRAFLGVPIIQRRQLLGVLVVQQREL-RQYDESEESFLVTLATQMAAILSQSQL 159
Cdd:smart00065 80 FAEDLLGRYQGVRSFLAVPLVADGELVGVLALHNKKSpRPFTEEDEELLQALANQLAIALANAQL 144
|
|
| GAF |
pfam01590 |
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ... |
18-154 |
4.58e-16 |
|
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460259 [Multi-domain] Cd Length: 133 Bit Score: 75.21 E-value: 4.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 18 LNEALDILVTDICLAMDTDVCSVYLADHDRRCYYLMATRGLKKPRGRTVtlafdEGIVGLVGRLAEPINLADAQKHPSF- 96
Cdd:pfam01590 2 LEEILQTILEELRELLGADRCALYLPDADGLEYLPPGARWLKAAGLEIP-----PGTGVTVLRTGRPLVVPDAAGDPRFl 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 495127080 97 KYIPSVREERFRAFLGVPIIQRRQLLGVLVVQQRElRQYDESEESFLVTLATQMAAIL 154
Cdd:pfam01590 77 DPLLLLRNFGIRSLLAVPIIDDGELLGVLVLHHPR-PPFTEEELELLEVLADQVAIAL 133
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
320-391 |
5.52e-15 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 70.13 E-value: 5.52e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495127080 320 PERFVLVADELSATTLAELpqDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHH-RMLVVDGYRG 391
Cdd:pfam00391 3 PEGVILVAPDTTPSDTAGL--DKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEgDLVTVDGSTG 73
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
2-478 |
1.91e-14 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 77.16 E-value: 1.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 2 LTRLREIVEKVASAPRLNEALDILVTDICLAMDTDVCSVYLADHDRRCYYLMATRGLkkPRGRTVTLAFDEGIVGLVGRL 81
Cdd:COG2203 192 LALLNEISQALRSALDLEELLQRILELAGELLGADRGAILLVDEDGGELELVAAPGL--PEEELGRLPLGEGLAGRALRT 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 82 AEPINLADAQKHPSFK--YIPSVREERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQL 159
Cdd:COG2203 270 GEPVVVNDASTDPRFApsLRELLLALGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAIERARL 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 160 TALFGQYRQTRIRALPASpgvaiapgWMDATLPLMEQVYEASTLDTGLERERLTTALEEAAGEFRRYSKRFAAGAQKETA 239
Cdd:COG2203 350 YEALEAALAALLQELALL--------RLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEGL 421
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 240 AIFDLYSHLLSDARLRRELYEEVDKGSVAEWAVKKVIEKFAEQFAALTDGYLKERAGDLRTLGQRLLFHLDDNIQSPNTW 319
Cdd:COG2203 422 LLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAVILLALALLAALLLLLLLLLALLALS 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 320 PERFVLVADELSATTLAELPQDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHHRMLVVDGYRGELLVDPSP 399
Cdd:COG2203 502 ALAVLASLLLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLLERELLTLVGVLLLLGLSVLLIELAL 581
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495127080 400 VLLHEYQRLLSEENELSRIAEDYVEQPACLKSGERVQVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEE 478
Cdd:COG2203 582 ALILALALLELLLVAVGDLLLLERDLLLLLVLLVRLLLELLVVTLELTVLVVLAAVEDSALLLRLALALASLVLLRALL 660
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
18-154 |
1.19e-12 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 65.57 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 18 LNEALDIlVTDICLAMD-TDVCSVYLADHDRRcyyLMATRGLKKPRGRTVTLAFDEGIVGLVGRLAEPINLADAQKHPSF 96
Cdd:pfam13185 4 LEELLDA-VLEAAVELGaSAVGFILLVDDDGR---LAAWGGAADELSAALDDPPGEGLVGEALRTGRPVIVNDLAADPAK 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 495127080 97 KYIPsVREERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAIL 154
Cdd:pfam13185 80 KGLP-AGHAGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAI 136
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
22-151 |
8.06e-06 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 45.82 E-value: 8.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 22 LDILVTDICLAMDTDVCSVYLADHDRRcyylmatrglkkprgRTVTLAFDEGIVGLVGRLAEPINLAD-AQKHPSFKYIP 100
Cdd:pfam13492 6 LEALLKLLVRLLGAERAAVYLLDEDGN---------------KLQVAAGYDGEPDPSESLDADSPLARrALSSGEPISGL 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 495127080 101 SVREE---RFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMA 151
Cdd:pfam13492 71 GSAGEdglPDGPALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIA 124
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
324-392 |
6.43e-05 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 45.98 E-value: 6.43e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495127080 324 VLVADELSattlaelPQD-RLM----GVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHHRMLV-VDGYRGE 392
Cdd:COG0574 386 ILVRDETD-------PDDvPGMkaaaGIVTERGGMTSHAAIVARELGIPAVVGCGDATRVLKDGDEItVDGTTGE 453
|
|
| FhlA |
COG3604 |
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ... |
101-154 |
8.54e-05 |
|
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 442823 [Multi-domain] Cd Length: 338 Bit Score: 45.22 E-value: 8.54e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 495127080 101 SVREERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAIL 154
Cdd:COG3604 67 ALAARERQLFLGVPLRVGGEVLGVLTLDSRRPGAFSEEDLRLLETLASLAAVAI 120
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
324-391 |
3.68e-04 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 43.35 E-value: 3.68e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495127080 324 VLVADELSATTLAELpqDRLMGVVVRDGAANSHAAIMVRAMGIPTVMGADIQPSVLHHRMLV-VDGYRG 391
Cdd:COG3848 245 ILVVPSTDAEFVPAI--EKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVtVDAERG 311
|
|
| MsrC |
COG1956 |
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, ... |
66-155 |
1.85e-03 |
|
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms];
Pssm-ID: 441559 [Multi-domain] Cd Length: 156 Bit Score: 39.43 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495127080 66 VTLAFDEGIVGLVGRLAEPINLADAQKHPsfKYI---PSVREErfrafLGVPIIQRRQLLGVLVVQQRELRQYDESEESF 142
Cdd:COG1956 70 TRIPFGKGVCGTAAAEGETQLVPDVHAFP--GHIacdSASRSE-----IVVPIFKDGEVIGVLDIDSPTPGRFDEEDQAG 142
|
90
....*....|...
gi 495127080 143 LVTLATQMAAILS 155
Cdd:COG1956 143 LEALAALLAEALD 155
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
345-392 |
8.56e-03 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 39.34 E-value: 8.56e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 495127080 345 GVVVRDGAANSHAAIMVRAMGIPTVM--GADIQPSvLHHRMLVVDGYRGE 392
Cdd:PRK05878 402 GIVTEVGGATSHAAVVSRELGRVAVVgcGAGVAAA-LAGKEITVDGYEGE 450
|
|
| |
