|
Name |
Accession |
Description |
Interval |
E-value |
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
84-405 |
0e+00 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 526.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 84 AWHYLSVRINRGEINLALRDLSSKLVVEEQLDLPLQEARPLLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGL 163
Cdd:cd24074 1 GWQFLSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 164 VRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVE 243
Cdd:cd24074 81 VHRLPFYDIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 244 IGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSMGSMLHGQPLSVESLCDAALAGDLLARDIILGVGVNVGR 323
Cdd:cd24074 161 LGHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLLEQSPDSMLHGQPISIESLCQAALAGDPLAQDIIIQVGRHLGR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 324 ILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAALVKDAMYNGSLLIRLL 403
Cdd:cd24074 241 ILAILVNLFNPEKILIGSPLNNAAEILFPALSQSIRQQSLPAYSQHLQIESTKFYNDGTMPGAALIKDALYDGSLLLKLL 320
|
..
gi 495143187 404 QG 405
Cdd:cd24074 321 QG 322
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
86-399 |
2.91e-101 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 303.13 E-value: 2.91e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 86 HYLSVRINRGEINLALRDLSSKLVVEEQLDLPLQEARPLLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGLVR 165
Cdd:cd24075 2 HILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVVH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 166 QMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIG 245
Cdd:cd24075 82 YMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 246 HTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSMGSMLHGQPLSVESLCDAALAGDLLARDIILGVGVNVGRIL 325
Cdd:cd24075 162 HIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKVI 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495143187 326 AIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAALVKDAMYNGSLL 399
Cdd:cd24075 242 AILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
|
|
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
82-389 |
3.94e-80 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 248.66 E-value: 3.94e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 82 TDAWHYLSVRINRGEINLALRDLSSKLVVEEQLDLPLQEARP-LLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTE 160
Cdd:COG1940 2 PDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEaVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 161 HGLVRQMP-FYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSS 239
Cdd:COG1940 82 TGVVLNAPnLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 240 SLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRmnqsmgsmLHGQPLSVESLCDAALAGDLLARDIILGVGV 319
Cdd:COG1940 162 NAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRAREL--------GGAEKLTAEELFAAARAGDPLALEVLDEAAR 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 320 NVGRILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAALV 389
Cdd:COG1940 234 YLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAAL 303
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
86-387 |
8.94e-68 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 217.07 E-value: 8.94e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 86 HYLSVRINRGEINLALRDLSSKLVVEEQLDLPLQEAR-PLLDRIIDHIDRFfIRHQRQLERLTAIAITLPGVIDTEHGLV 164
Cdd:cd24059 2 YVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENPeEVLEKLYELIDRL-LEKENIKSKILGIGIGAPGPLDVEKGII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 165 RQMP-FYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVE 243
Cdd:cd24059 81 LNPPnFPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 244 IGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSMGSMLHgqplsvesLCDAALAGDLLARDIILGVGVNVGR 323
Cdd:cd24059 161 IGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGRSFQLD--------IVEALQKGDPIADEVIEEAAKYLGI 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495143187 324 ILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAA 387
Cdd:cd24059 233 GLVNLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEDAPLLGAA 296
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
85-373 |
4.64e-67 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 215.11 E-value: 4.64e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 85 WHYLSVRINRGEINLALRDLSSKLVVEEQLDLPLQEARPLLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGLV 164
Cdd:cd24073 1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGIC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 165 RQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEI 244
Cdd:cd24073 81 RWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 245 GHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQsmgsmlhGQPLSVESLCDAALAGDLLARDIILGVGVNVGRI 324
Cdd:cd24073 161 GHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLR-------GEPLTIEDLLAAARAGDPAARAILRRAGRALGLA 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495143187 325 LAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVE 373
Cdd:cd24073 234 LANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELV 282
|
|
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
85-387 |
2.27e-59 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 195.09 E-value: 2.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 85 WHYLSVRINRGEINLALRDLSSKLVVEEQLDLPL-QEARPLLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGL 163
Cdd:cd24076 1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPAsDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 164 VRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHaGSSSLV- 242
Cdd:cd24076 81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYR-GASGFAg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 243 EIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQsmgsmlhGQPLSVESLCDAALAGDLLARDIILGVGVNVG 322
Cdd:cd24076 160 EIGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAG-------GEPLSLAELVEAARAGDPAALAALEEVGEYLG 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495143187 323 RILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAA 387
Cdd:cd24076 233 IGLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAA 297
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
86-389 |
6.42e-51 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 173.24 E-value: 6.42e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 86 HYLSVRINRGEINLALRDLSSKLVveEQLDLPL---QEARPLLDRIIDHIDRFfIRHQRQLERLTAIAITLPGVIDTEHG 162
Cdd:cd24071 2 YIIGVKIEEGYLVLALTDLKGKIL--EKTRIPFdheTDPEKVIELIAENIKKL-IKNKHVEKKLLGIGIAVSGLVDSKKG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 163 LVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLV 242
Cdd:cd24071 79 IVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 243 EIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQS-MGSMLHGQPLSVESLCDAALAGDLLARDIILGVGVNV 321
Cdd:cd24071 159 EIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYpLSLLKELEDFEIEKVREAAEEGDSVATELFKKAGEYL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495143187 322 GRILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAALV 389
Cdd:cd24071 239 GIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLGEDAWVLGAALL 306
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
88-391 |
1.05e-49 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 169.83 E-value: 1.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 88 LSVRINRGEINLALRDLSSKLVVEEQLDLPLQEARPLLdriIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGLVRQM 167
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILARERVPTPTTTTEETL---VDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 168 PFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHT 247
Cdd:pfam00480 78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 248 QVDPYGKRCYCGNHGCLETIASIDSVLELAQQRmnqsmgsmlhGQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAI 327
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQK----------GEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIAN 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495143187 328 MVNLFNPQKILIGSPLNrASDILFPAIADAVRQQSLPAYSRN-ISVESTQFSN-RGTMAGAALVKD 391
Cdd:pfam00480 228 LINLFDPQAIVLGGGVS-NADGLLEAIRSLVKKYLNGYLPVPpVIIVAASLGDnAGALGAAALAKQ 292
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
86-359 |
4.12e-48 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 166.05 E-value: 4.12e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 86 HYLSVRINRGEINLALRDLSSKLVVEE---QLDLPLQEArpLLDRIIDHIDRffiRHQRQLERLTAIAITLPGVIDTEHG 162
Cdd:cd24072 2 WVLGIVVSPNSLRAQVGNACGELLGEFeyrVITLETPEA--LIDEIIDCIDR---LLKLWKDRVKGIALAIQGLVDSHKG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 163 LVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLV 242
Cdd:cd24072 77 VSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 243 EIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSMGSmLHGQPLSVESLCDAALAGDLLARDIILGVGVNVG 322
Cdd:cd24072 157 EIGHTKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVS-ADPEKLTMEQLIEALEEGEPIATQIFDRAANAIG 235
|
250 260 270
....*....|....*....|....*....|....*..
gi 495143187 323 RILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVR 359
Cdd:cd24072 236 RSLANILNLLNPEQVLLYGRGCRAGDLLLPAIRRAIA 272
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
97-387 |
2.49e-47 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 164.00 E-value: 2.49e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 97 INLALRDLSSKLVVEEQLDLPLQEARP-LLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGLVRQMPFYDVVDM 175
Cdd:cd24062 12 IKMAFLTQEGEIVQKWEIPTNKLEGGEnIITDIAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTVEVAVNLGWKNF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 176 PLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDPY-GK 254
Cdd:cd24062 92 PLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIGHITVNPEgGA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 255 RCYCGNHGCLETIASIDSVLELAQQRMNQSMGSML-----HGQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMV 329
Cdd:cd24062 172 PCNCGKTGCLETVASATGIVRIAREELEEGKGSSAlrilaLGGELTAKDVFEAAKAGDELALAVVDTVARYLGLALANLA 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 495143187 330 NLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAA 387
Cdd:cd24062 252 NTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFPRVRQDTEIVLATLGNDAGVIGAA 309
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
97-388 |
2.41e-44 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 155.41 E-value: 2.41e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 97 INLALRDLSSKLVVEEQLDLPLQEARP-LLDRIIDHIDRFFIRHQrqlerLTAIAITLPGVIDTEHGLVR----QMPFYd 171
Cdd:cd24068 12 IKYGLVDADGEILEKDSVPTPASKGGDaILERLLEIIAELKEKYD-----IEGIGISSAGQVDPKTGEVIyatdNLPGW- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 172 vVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDP 251
Cdd:cd24068 86 -TGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMVVDP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 252 YGKRCYCGNHGCLETIASIDSVLELAQQRMNQSmgsmlhgqPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVNL 331
Cdd:cd24068 165 GGRPCCCGGKGCLEQYASGTALVRRVAEALGEP--------GIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHI 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 495143187 332 FNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAAL 388
Cdd:cd24068 237 FDPEVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAKLGNDAGLLGAAY 293
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
144-387 |
9.17e-42 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 149.18 E-value: 9.17e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 144 ERLTAIAITLPGVIDTEHGLVRQMP-FYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHN 222
Cdd:cd24064 54 MELLGIGIGSPGSIDRENGIVRFSPnFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 223 VGAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSMGSmLHGQPLSVES--LC 300
Cdd:cd24064 134 VGSGVICHGQLLTGYDGIAAELGHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRYPDS-LAGESEKINAkhVF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 301 DAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNR 380
Cdd:cd24064 213 DAARKNDPLATMVFRRVVDALAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNLVED 292
|
....*..
gi 495143187 381 GTMAGAA 387
Cdd:cd24064 293 AGILGAA 299
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
88-389 |
2.38e-39 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 140.68 E-value: 2.38e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 88 LSVRINRGEINLALRDLSSKLVVEEQLDLPL-QEARPLLDRIIDHIDRFfIRHQRQLERLTAIAITLPGVIDTEHGLVRQ 166
Cdd:cd23763 1 IGIDIGGTKIRAALVDLDGEILARERVPTPAeEGPEAVLDRIAELIEEL-LAEAGVRERILGIGIGVPGPVDPETGIVLF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 167 MP-FYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIG 245
Cdd:cd23763 80 APnLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 246 HTQVdpygkrcycgnhgcletiasidsvlelaqqrmnqsmgsmlhgqplsVESLCDAalagdllardiiLGVGvnvgriL 325
Cdd:cd23763 160 HITV----------------------------------------------LEEAARY------------LGIG------L 175
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495143187 326 AIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQSLPAYSRNISVESTQFSNRGTMAGAALV 389
Cdd:cd23763 176 ANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELGDDAGLLGAAAL 239
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
124-387 |
4.01e-34 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 128.63 E-value: 4.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 124 LLDRIIDHIDRFFIRHQrqlerLTAIAITLPGVIDTEHGLVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEG 203
Cdd:cd24061 37 IVDAIVEAVEELREGHD-----VSAVGVAAAGFVDADRATVLFAPNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 204 LFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMN- 282
Cdd:cd24061 112 RFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGHIRVVPDGLLCGCGSRGCWEQYASGRALVRYAKEAANa 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 283 -----QSMGSMLHGQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIGSPLNRASDILFPAIADA 357
Cdd:cd24061 192 tpegaAVLLADGSVDGITGKHISEAARAGDPVALDALRELARWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIREA 271
|
250 260 270
....*....|....*....|....*....|..
gi 495143187 358 VRqQSLPAY-SRNI-SVESTQFSNRGTMAGAA 387
Cdd:cd24061 272 FE-RWLPGRgWRPIpRLRTAQLGNDAGLIGAA 302
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
86-389 |
7.41e-34 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 127.66 E-value: 7.41e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 86 HYLSVRINRGEINLALRDLSSKLVVEEQLDLPLQEARPLLDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHglVR 165
Cdd:cd24077 2 YSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVDENE--II 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 166 QMPFYDVVDMPLGAALEAHTGVPVFVQHD--ISAwtMAEGLFgaSRGARDVIQVVIDHNVGAGVITDGRLLH-----AGs 238
Cdd:cd24077 80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEanLSA--LAERTF--SEDYDNLISISIHSGIGAGIIINNQLYRgyngfAG- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 239 sslvEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSmgsmlhgqPLSVESLCDAALAGDLLARDII---- 314
Cdd:cd24077 155 ----EIGHMIIVPNGKPCPCGNKGCLEQYASEKALLKELSEKKGLE--------TLTFDDLIQLYNEGDPEALELIdqfi 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495143187 315 --LGVGVNVgrilaiMVNLFNPQKILIGSPLNRAsdilFPAIADAVRQQsLPAYSRN-ISVESTQFSNRGTMAGAALV 389
Cdd:cd24077 223 kyLAIGINN------IINTFNPEIIIINSSLINE----IPELLEKIKEQ-LSSSFNKyVEILISTLGKNATLLGGAAV 289
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
125-362 |
5.04e-31 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 119.74 E-value: 5.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 125 LDRIIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGLVRQMP-FYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEG 203
Cdd:cd24065 35 GEAVLDALARAVEALQAEAPGVEAVGLGVPGPLDFRRGRVRFAPnIPGLTDFPIRRGLAERLGLPVVLENDANAAALAEH 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 204 LFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAqqrmnq 283
Cdd:cd24065 115 HYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRALARDA------ 188
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495143187 284 smgSMLHGQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIGSPLNRASDILFPAIADAVRQQS 362
Cdd:cd24065 189 ---SFAYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLLPVQEAARRYT 264
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
124-388 |
3.59e-29 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 115.51 E-value: 3.59e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 124 LLDRIIDHIDRFFirHQRQLERLTAIAITLPGVIDTEHGLVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEG 203
Cdd:cd24063 40 VSEQVLGLIETLL--SKAGKDSIEGIGVSSAGPLDLRKGTIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 204 LFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDP-YGKRCYCGNHGCLETIASIDSVLELAQQRM- 281
Cdd:cd24063 118 LFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGHLVVDTeSGLKCGCGGYGHWEAFASGRGIPRFAREWAe 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 282 NQSMGSMLH-----GQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIGSPLNRASDILF-PAIA 355
Cdd:cd24063 198 GFSSRTSLKlrnpgGEGITAKEVFSAARKGDPLALKIIEKLARYNGRGIANVINAYDPELIVIGGSVFNNNKDILdPLIE 277
|
250 260 270
....*....|....*....|....*....|....
gi 495143187 356 DAVRqqsLPAYSRNISVESTQFSNR-GTMAGAAL 388
Cdd:cd24063 278 YLEK---NPAISKGPEIVLSELGDDvGLIGALAL 308
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
145-388 |
3.77e-23 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 98.64 E-value: 3.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 145 RLTAIAITLPGVIDTEHGLV----RQMPFYDVVDmpLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVID 220
Cdd:cd24060 59 RILGVGISTGGRVNPREGIVlhstKLIQEWSSVD--LRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 221 HNVGAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMNQSM-----GSMLHGQPLS 295
Cdd:cd24060 137 TGIGGGIILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAKKLHDEDLllvegMSVTNDEEVT 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 296 VESLCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIGSPLnraSDILFPAIADAVRQQSLPAySRNISVEST 375
Cdd:cd24060 217 AKHLIQAAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVL---ASHYENIVKDVIAQRALPS-VQNVDVVVS 292
|
250
....*....|...
gi 495143187 376 QFSNRGTMAGAAL 388
Cdd:cd24060 293 DLVDPALLGAASM 305
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
128-340 |
3.00e-21 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 93.04 E-value: 3.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 128 IIDHIDRFFIRHQRQLERLTAIAITLPGVIDTEHGLVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGA 207
Cdd:cd24066 38 TLDAIADLVEEAEEELGAPATVGIGTPGSISPRTGLVKNANSTWLNGKPLKADLEARLGRPVRIENDANCFALSEATDGA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 208 SRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDPY------GKRCYCGNHGCLETIASiDSVLELAQQRM 281
Cdd:cd24066 118 GAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGHNPLPWPdedelpGPPCYCGKRGCVETFLS-GPALERDYARL 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 495143187 282 nqsmgsmlHGQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIG 340
Cdd:cd24066 197 --------TGKTLSAEEIVALARAGDAAAVATLDRFLDRLGRALANVINILDPDVIVLG 247
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
124-340 |
3.54e-20 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 89.92 E-value: 3.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 124 LLDRIIDHIDRFFIRHQRQLErltAIAITLPGVIDTEHGLVRQMPFYDVVD-MPLGAALEAHTGVPVFVQHDISAWTMAE 202
Cdd:cd24070 41 PVEVLADLIREYIEEAGLKPA---AIVIGVPGTVDKDRRTVISTPNIPGLDgVNLADILENKLGIPVILERDVNLLLLYD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 203 GLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQrmn 282
Cdd:cd24070 118 MRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYASGRALEEIAEE--- 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495143187 283 qsmgsmlHGQPLSVESL-CDAALAGDLlaRDII--LGVGVnvgrilAIMVNLFNPQKILIG 340
Cdd:cd24070 195 -------HYPDTPILDIfVDHGDEPEL--DEFVedLALAI------ATEINILDPDAVILG 240
|
|
| ASKHA_NBD_ROK_NAGK |
cd24057 |
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
97-389 |
4.26e-20 |
|
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 89.60 E-value: 4.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 97 INLALRDLSSKLVVEEQLDLPLQEARPLLDRIIDHIDRFFIRHQRQlerlTAIAITLPGVIDTEHGLVRQMPFYDVVDMP 176
Cdd:cd24057 12 IEFAVFDEALQLVWTKRVPTPTDDYAAFLAAIAELVAEADARFGVK----GPVGIGIPGVIDPEDGTLITANIPAAKGRP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 177 LGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHT------QVD 250
Cdd:cd24057 88 LRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGIAGEWGHGplpadaLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 251 PYG---KRCYCGNHGCLETIASIDSVLELAQQrmnqsmgsmLHGQPLSVESLCDAALAGDLLAR---DIILGVgvnVGRI 324
Cdd:cd24057 168 GYDlpvLRCGCGQTGCLETYLSGRGLERLYAH---------LYGEELDAPEIIAAWAAGDPQAVahvDRWLDL---LAGC 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495143187 325 LAIMVNLFNPQKILIGSPLNRASDILfPAIADAVRQQSLPAYSRNIsVESTQFSNRGTMAGAALV 389
Cdd:cd24057 236 LANILTALDPDVVVLGGGLSNFPALI-AELPAALPAHLLSGARTPR-IVPARHGDAGGVRGAAFL 298
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
139-388 |
4.49e-19 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 86.57 E-value: 4.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 139 HQRQLERLtAIAITlpGVIDteHGLVR-----QMPFYDvvDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARD 213
Cdd:cd24069 48 YQGQFDRV-AVAST--GIIR--DGVLTalnpkNLGGLS--GFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGN 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 214 VIQVVIDHNVGAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASIDSVLELAQQRMnqsmgsmlhGQP 293
Cdd:cd24069 121 LVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIASGTAIAAAASEIL---------GEP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 294 LSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIGsplnrASDILFPAIADAVRQ--QSLPAYSRnIS 371
Cdd:cd24069 192 VDAKDVFERARSGDEEAARLIDRAARALADLIADLKATLDLDCVVIG-----GSVGLAEGFLERVEQylADEPAIFR-VS 265
|
250
....*....|....*..
gi 495143187 372 VESTQFSNRGTMAGAAL 388
Cdd:cd24069 266 LEPARLGQDAGLLGAAL 282
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
97-340 |
8.12e-17 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 79.92 E-value: 8.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 97 INLALRDLSSKLVVEEQLDLPLQEARPLLDRIIDHIDRFfirhqrqLERLTAIAITLPGVIDTEHGLVRQM-PFYDVVDM 175
Cdd:cd24152 12 IKYALVDENGNIIKKGKIPTPKDSLEEFLDYIKKIIKRY-------DEEIDGIAISAPGVIDPETGIIYGGgALPYLKGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 176 PLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLH-----AGssslvEIGHTQVD 250
Cdd:cd24152 85 NLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRgshffAG-----EFSYLLTD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 251 PYGKRCYCGNHGCletiaSIDSVLELAQQRMNQsmgsmlhgQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVN 330
Cdd:cd24152 160 DDDKDLLFFSGLA-----SMFGLVKRYNKAKGL--------EPLDGEEIFEKYAKGDEAAKKILDEYIRNLAKLIYNIQY 226
|
250
....*....|
gi 495143187 331 LFNPQKILIG 340
Cdd:cd24152 227 ILDPEVIVIG 236
|
|
| PRK09698 |
PRK09698 |
D-allose kinase; Provisional |
123-340 |
2.53e-12 |
|
D-allose kinase; Provisional
Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 66.93 E-value: 2.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 123 PLLDRIIDHIDRFFIRHQRqleRLTAIAITLPGVIDTEHGLVRQMPFYDVV---DMPLGAALEAHTGVPVFVQHDIS--- 196
Cdd:PRK09698 42 DLVSGLGEMIDEYLRRFNA---RCHGIVMGFPALVSKDRRTVISTPNLPLTaldLYDLADKLENTLNCPVFFSRDVNlql 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 197 AWtmaeglfgasrgarDVIQVVIDHNV----------GAGVITDGRLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLET 266
Cdd:PRK09698 119 LW--------------DVKENNLTQQLvlgaylgtgmGFAVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLET 184
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495143187 267 IAS-IDSVLELAQQRMNQSMGSML--HGQPLSVESLCdaalagDLLARDIilgvgvnvgrilAIMVNLFNPQKILIG 340
Cdd:PRK09698 185 NCSgMALRRWYEQQPRDYPLSDLFvhAGDHPFIQSLL------ENLARAI------------ATSINLFDPDAIILG 243
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
173-340 |
4.72e-12 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 66.09 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 173 VDMPLGAALEAHTGVPVFVQHDISAWTMAEglFGASRGA-RDVIQVVIDHNVGAGVITDGRLlHAGSSSLV-EIGHTQVD 250
Cdd:PRK05082 84 LHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDiRNMVFITVSTGVGGGIVLNGKL-LTGPGGLAgHIGHTLAD 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 251 PYGKRCYCGNHGCLETIASIDSVLELAQQRMnqsmgsmlhgQPLSVESLCDAALAGDLLARDIILGVGVNVGRILAIMVN 330
Cdd:PRK05082 161 PHGPVCGCGRRGCVEAIASGRAIAAAAQGWL----------AGCDAKTIFERAGQGDEQAQALINRSAQAIARLIADLKA 230
|
170
....*....|
gi 495143187 331 LFNPQKILIG 340
Cdd:PRK05082 231 TLDCQCVVLG 240
|
|
| PRK09557 |
PRK09557 |
fructokinase; Reviewed |
149-340 |
4.31e-10 |
|
fructokinase; Reviewed
Pssm-ID: 236565 [Multi-domain] Cd Length: 301 Bit Score: 60.42 E-value: 4.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 149 IAITLPGVIDTEHGLVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVI 228
Cdd:PRK09557 60 VGVGIPGSISPYTGLVKNANSTWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 229 TDGRLlHAGSSSLV-EIGHTQV-----DPYGKR----CYCGNHGCLETIASIDSVLELAQQrmnqsmgsmLHGQPLSVES 298
Cdd:PRK09557 140 INGRV-HIGGNGIAgEWGHNPLpwmdeDELRYRnevpCYCGKQGCIETFISGTGFATDYRR---------LSGKALKGSE 209
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 495143187 299 LCDAALAGDLLARDIILGVGVNVGRILAIMVNLFNPQKILIG 340
Cdd:PRK09557 210 IIRLVEEGDPVAELAFRRYEDRLAKSLAHVINILDPDVIVLG 251
|
|
| ASKHA_NBD_ROK_BsFRK-like |
cd24067 |
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ... |
126-360 |
3.00e-07 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466917 [Multi-domain] Cd Length: 285 Bit Score: 51.39 E-value: 3.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 126 DRIIDHIDRFFIRHQrqlERLTAIAITLPGVIDtehgLVRQMPFYDVV---------DMPLGAALEAHTGVPVFVQHDIS 196
Cdd:cd24067 34 EETLQAVIDFFREQE---EPIDAIGIASFGPID----LNPTSPTYGYItttpkpgwrNFDILGALKRAFPVPVGFDTDVN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 197 AWTMAEGLFGASRGARDVIQVVIDHNVGAGVITDGRLLHAgsssLV--EIGHTQV------DPYGKRC-YcgnHG-CLET 266
Cdd:cd24067 107 AAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHG----LLhpEMGHIRVprhpddDGFPGVCpF---HGdCLEG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 267 IASIDSVlelaQQRMNqsmgsmlhgqpLSVESLCDAALAGDLLARDIilgvgvnvGRILAIMVNLFNPQKILI-GSPLNR 345
Cdd:cd24067 180 LASGPAI----AARWG-----------IPAEELPDDHPAWDLEAYYL--------AQACANLTLTLSPERIVLgGGVMQR 236
|
250
....*....|....*
gi 495143187 346 AsdILFPAIADAVRQ 360
Cdd:cd24067 237 P--GLFPRIREKFRK 249
|
|
| PRK13310 |
PRK13310 |
N-acetyl-D-glucosamine kinase; Provisional |
149-387 |
1.10e-06 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 49.99 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 149 IAITLPGVIDTEHGLVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGVI 228
Cdd:PRK13310 60 VGIGIPGMPETEDGTLYAANVPAASGKPLRADLSARLGRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 229 TDGRLlHAGSSSLV-EIGHTQVdPYGK-----------RCYCGNHGCLETIASidsvlelaqQRMNQSMGSMLHGQPLSV 296
Cdd:PRK13310 140 FNGKP-ISGRSYITgEFGHMRL-PVDAltllgwdaplrRCGCGQKGCIENYLS---------GRGFEWLYQHYYGEPLQA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 297 ESLCDAALAGDLLARDiilgvgvNVGR---ILAIMV-NLF---NPQKILIGSPLNRasdilFPAIADAVrQQSLPAY--- 366
Cdd:PRK13310 209 PEIIALYYQGDEQAVA-------HVERyldLLAICLgNILtivDPHLVVLGGGLSN-----FDAIYEQL-PKRLPRHllp 275
|
250 260
....*....|....*....|..
gi 495143187 367 -SRNISVESTQFSNRGTMAGAA 387
Cdd:PRK13310 276 vARVPRIEKARHGDAGGVRGAA 297
|
|
| ASKHA_NBD_ROK_PPGK |
cd24058 |
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ... |
149-388 |
2.83e-06 |
|
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466908 [Multi-domain] Cd Length: 239 Bit Score: 47.95 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 149 IAITLPGVIdtEHGLVRQMPFYDV--VDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVV-IDHNVGA 225
Cdd:cd24058 58 VGVGFPGVV--RRGVVRTAANLDKswIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLtLGTGIGS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 226 GVITDGRLLHAgssslVEIGHTQVDpygkrcycgnHGCLETIASiDSVLELaqqrmnqsmgsmlhgqplsvESLCDAALA 305
Cdd:cd24058 136 ALFVDGHLVPN-----TELGHLEIR----------GKDAEERAS-LGVRAR--------------------EDLGWKRWA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 306 GdllardiilgvgvNVGRILAIMVNLFNPQKILIGSPLNRASDILFPAIadAVRQQSLPAysrnisvestQFSNRGTMAG 385
Cdd:cd24058 180 K-------------RVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLL--DVKTPVVPA----------VLRNDAGIVG 234
|
...
gi 495143187 386 AAL 388
Cdd:cd24058 235 AAL 237
|
|
| PRK13311 |
PRK13311 |
N-acetyl-D-glucosamine kinase; Provisional |
148-269 |
2.29e-03 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 106271 [Multi-domain] Cd Length: 256 Bit Score: 39.63 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495143187 148 AIAITLPGVIDTEHGLVRQMPFYDVVDMPLGAALEAHTGVPVFVQHDISAWTMAEGLFGASRGARDVIQVVIDHNVGAGV 227
Cdd:PRK13311 59 SVGIGIPGLPNADDGTVFTANVPSAMGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGL 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 495143187 228 ITDGRLLHAGSSSLVEIGHTQV-----DPYGKR-----CYCGNHGCLETIAS 269
Cdd:PRK13311 139 IVNGSIVSGRNHITGEFGHFRLpvdalDILGADiprvpCGCGHRGCIENYIS 190
|
|
| Fe_dep_repress |
pfam01325 |
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ... |
20-60 |
2.43e-03 |
|
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.
Pssm-ID: 396062 [Multi-domain] Cd Length: 57 Bit Score: 35.81 E-value: 2.43e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 495143187 20 AVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLV 60
Cdd:pfam01325 9 TIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYV 49
|
|
| |
