|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
1-471 |
0e+00 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 801.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 1 MTDLPQNVRWQLWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
Cdd:PRK10504 1 MTDLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 81 AIVLFTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEY 160
Cdd:PRK10504 81 AIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 161 ASWHWIFLINLPVGIAGAAATLWLMPNYTMQTRRFDFSGFLLLAFGMAALTIALDGYRSTGLSPAGLGALVAGGSAATLL 240
Cdd:PRK10504 161 ASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 241 YLWHARGNERALFSLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQV 320
Cdd:PRK10504 241 YLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 321 VNRFGYRRVLVASTLALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQL 400
Cdd:PRK10504 321 VNRFGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495144450 401 SMSLGVSIAGLLLGAFGHNQLAADSGDAHGIFFWTYLCMALIIALPALVFARVPDDISKNAVIARRKRSAS 471
Cdd:PRK10504 401 SMSIGVTIAGLLLGLFGQQHVSVDSGATHTVFMYTYLCMALIIALPALIFARVPNDTHQNVAISRRKRSAQ 471
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-454 |
9.60e-82 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 257.50 E-value: 9.60e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 15 VAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQ 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 95 SSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVG 174
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 175 IAGAAATlwlmpnytmqtrrfdfsgflllafgmaaltialdgyrstglspaglgalvaggsaatllylwhargnerALFS 254
Cdd:cd17503 161 ILALLLA---------------------------------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 255 LRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVAST 334
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 335 LALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLG 414
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 495144450 415 AFGHNQLAADSGDAHGI---------FFWTYLCMALIIALPALVFARVP 454
Cdd:cd17503 332 NRTQFHHSRLSELLAQQvqkqaliiaFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
18-423 |
3.11e-48 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 172.56 E-value: 3.11e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 18 GFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSST 97
Cdd:TIGR00711 10 GTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 98 LNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVGIAG 177
Cdd:TIGR00711 90 LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 178 AAATLWLMPNYT-MQTRRFDFSGFLLLAFGMAALTIALDGYRSTG-LSPAGLGALVAGGSAATLLYLWHARGNERALFSL 255
Cdd:TIGR00711 170 VVVAFFILPRDKpAASENFDFLGLLLLSVGLGSLLYGLSEGPERGwFDSNEILILSITGLVAIIAFVVWELTDDNPLVDL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 256 RLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASTL 335
Cdd:TIGR00711 250 RLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 336 ALALVTLLF-MGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLG 414
Cdd:TIGR00711 330 LYAVGFYWRaFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
|
410
....*....|..
gi 495144450 415 ---AFGHNQLAA 423
Cdd:TIGR00711 410 nrtQFHHSQLTE 421
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-454 |
3.89e-40 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 148.09 E-value: 3.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 15 VAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQ 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 95 SSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVG 174
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 175 IAGaaatlwlmpnytmqtrrfdfsgflllafgmaaltialdgyrstglspaglgalvaggsaatllylwhargneralfs 254
Cdd:cd17321 161 LVA----------------------------------------------------------------------------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 255 lrLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVAST 334
Cdd:cd17321 164 --LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 335 LALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLG 414
Cdd:cd17321 242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 495144450 415 AFGHNQL---------AADSGDAHGIFFWTYLCMALIIALPALVFARVP 454
Cdd:cd17321 322 AGLSANLgdsgvaallSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-404 |
6.03e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 127.78 E-value: 6.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 1 MTDLPQNVRWQLWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 81 AIVLFTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEY 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 161 ASWHWIFLINLPVGIAGAAATLWLMPNYTMQTRRFDFSGFlllafgmaaltialdgyrstglspaglgalvaggsaatll 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL---------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 241 ylwhargneralfsLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQV 320
Cdd:COG2814 201 --------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 321 VNRFGYRRVLVAStlaLALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQL 400
Cdd:COG2814 267 ADRFGRRRLLLIG---LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
....
gi 495144450 401 SMSL 404
Cdd:COG2814 344 GGPL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-271 |
4.03e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 104.89 E-value: 4.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 9 RWQLWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 89 SLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFL 168
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 169 INLPVGIAGAAATLWLMPNYTMQTRRFDFSGFLLLAFGMAALTIALDGYRSTGLSPAGLGALVAGGSAATLLYLWHARGN 248
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260
....*....|....*....|...
gi 495144450 249 ERALFSLRLFNTRTFSLGLFGSL 271
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALL 275
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
20-408 |
1.63e-24 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 103.80 E-value: 1.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 20 FMQALDTTIVNTALPSMAASLGESPLrMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLN 99
Cdd:cd17502 6 FLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 100 ELVAARVLQGVGGAMMVPVGRLTVMKIVP---RDQYMAAMTFVTLPGQVgplLGPALGGLLVEYASWHWIFLINLPVGIa 176
Cdd:cd17502 85 MLIVGRAIQGIGGGGLMSLAFIIIADLVPpreRGKYQGYIGAVFGIASV---AGPLIGGAFTDHLSWRWCFYINLPIGG- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 177 gaaatlwlmpnytmqtrrfdfsgflllafgmaaltialdgyrstglspaglgalvaggsaatllylwhargneralfsLR 256
Cdd:cd17502 161 ------------------------------------------------------------------------------LA 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 257 LFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFG-YRRVLVASTL 335
Cdd:cd17502 163 LALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495144450 336 ALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSI 408
Cdd:cd17502 243 LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
23-416 |
6.71e-24 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 104.04 E-value: 6.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 23 ALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELV 102
Cdd:PRK14995 19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 103 AARVLQGVGGAMMVPVGRLTVMKIV--PRDQYMAAMTFVTLpGQVGPLLGPALGGLLVEYASWHWIFLINLPVGIAGAAA 180
Cdd:PRK14995 99 ATRALLAIGAAMIVPATLAGIRATFteEKQRNMALGVWAAV-GSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 181 TLWLMPNYTMQTRR-FDFSGFLLLAFGMAALTIALDGYRSTGLSPAGLGALVAGGSAATLLYLWHARGNERALFSLRLFN 259
Cdd:PRK14995 178 TARYVPRQAGRRDQpLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 260 TRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVlvaSTLALAL 339
Cdd:PRK14995 258 HRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLV---ATGGMAL 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 340 VTLLFMGVALAGW---YWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLGAF 416
Cdd:PRK14995 335 SALSFYGLAMTDFstqQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRS 414
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-405 |
9.17e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 9.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 15 VAFGFFMQALDTTIVNTALPS-MAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 94 QSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPV 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 174 GIAGAAATLWLMPNYTMQTRRFdfsgflllafgmaaltialdgyrstglspaglgalvaggsaatllylwHARGNERALF 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP------------------------------------------------AEEARLSLIV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 254 SLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIgLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVAS 333
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495144450 334 TLALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLG 405
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
15-449 |
1.85e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 86.86 E-value: 1.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 15 VAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQ 94
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 95 SSTLNELVAARVLQGVGGAmMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVG 174
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 175 IAGAAATlwlmpnytmqtrrfdfsgflllafgmaaltialdgyrstglspaglgalvaggsaatllylwhargnerALFS 254
Cdd:cd17504 160 VLLAALV---------------------------------------------------------------------PLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 255 LRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQ----IGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVL 330
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 331 VASTLALALVTLLFMGVALAGwyWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAG 410
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSSL--WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 495144450 411 LLLGAF--GHNQLAADSGDAHGIFFWTYLCMALIIALPALV 449
Cdd:cd17504 329 AILTTYtvSITSGGVPTEGAYVLAFLIGAALALAALLLSLL 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-452 |
2.14e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 83.38 E-value: 2.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 2 TDLPQNVRWQLWIVAF-GFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80
Cdd:COG2271 1 ARAPSRYRWRILALLFlAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 81 AIVLFTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEY 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 161 ASWHWIFLINLPVGIAGAAATLWLMpnytmqtrrfdFSGFLLLAFGMAALTialdgyrstglspaglgalvaggsaatll 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL-----------ALAYFLVYFALYGFL----------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 241 ylwhargneralfslrlfntrtfslglfgslcgrigsgmlpFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQV 320
Cdd:COG2271 201 -----------------------------------------TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWL 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 321 VNRFGYRRVLVASTLALALVTLLFMGVALAGWYWLLPVVMLFqGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQL 400
Cdd:COG2271 240 SDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL 318
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 495144450 401 SMSLGVSIAGLLLGAFGHNqlaadsgdahgIFFWTYLCMALIIALPALVFAR 452
Cdd:COG2271 319 GGALGPLLVGYLLDATGYQ-----------AAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-414 |
4.68e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 82.62 E-value: 4.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINL 171
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 172 PVGIAGAAATLWLMPNYTMQTRRFDFSGFLLLAFgmaaltialdgyrstglspaglgalvaggsaatllylwhargneRA 251
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY--------------------------------------------KR 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 252 LFSLRLFNTRTFSLGLFgslcgriGSGMLPFMT--PVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRV 329
Cdd:cd17320 197 VLKNRRFLGYALALGLS-------FAGLFAYLAaaPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 330 LVASTLALALVTLLFMGVALAGWYWLLPVVMLFQGMV--NSVRFSTMNTLTLRDLPdEMASSGNSLLSMVMQLSMSLGVS 407
Cdd:cd17320 270 LRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFfgFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGA 348
|
....*..
gi 495144450 408 IAGLLLG 414
Cdd:cd17320 349 LVGLLPN 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-452 |
9.63e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.47 E-value: 9.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 15 VAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQ 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 95 SSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVG 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 175 IAGAAATLWLMPNYTMQTRRFDfsgflllafgmaaltialdgyrstglspaglgalvaggsaatllylwhARGNERALFS 254
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRA------------------------------------------------VSAARLRSGL 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 255 LRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASt 334
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 335 laLALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLG 414
Cdd:cd17325 272 --LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
410 420 430
....*....|....*....|....*....|....*...
gi 495144450 415 AFGhnqlaadsgdahgiFFWTYLCMALIIALPALVFAR 452
Cdd:cd17325 350 AFG--------------FATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-453 |
1.38e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 78.00 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQ-------YMAAMTFVTLPGQVGPLLGPAlggllveyASWH 164
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGErakamglYEAALGLGIAVGPLLGGLLAA--------ISWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 165 WIFLINLPVGIAGAAATLWLMPNYTMQTRRFDFSGFLLLafgmaaltialdgyrstglspaglgalvaggsaatllylwh 244
Cdd:cd17474 153 YPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDL----------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 245 argneralfsLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPM----VLGSMGIKRIVVQv 320
Cdd:cd17474 192 ----------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWsvllALGSLFVGRLLKK- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 321 vnRFGYRRVLVASTLALALVTLLFMGVALAGWYWLLPVVM-LFQGMVNsvrfSTMNTLTLRDLPDEMASSGNSLLSMVMQ 399
Cdd:cd17474 261 --RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFgLGLGLNL----PLLTTLVTELAPEEERGTASSLYNFVRF 334
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 495144450 400 LSMSLGVSIAGLLLGAFGHNqlaadsgdahgiffWTYLCMALIIALPALVFARV 453
Cdd:cd17474 335 LGQAVGPLLFGLLLEIFGLS--------------APFLVGAAIALAAAVLLALL 374
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
14-311 |
1.22e-13 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 73.04 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 14 IVAFGFFMQALDTTIVNTALPSMAASLGESPLRMhMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 94 QSSTLNELVAARVLQGVGGAmMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVE--YASWHWIFLINL 171
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 172 pvGIAGAAATLWLM----PNYTM--------QTRRFDFSGFLLLAFGMAALTIAL----DGYRSTglSPAGLGALVAGGS 235
Cdd:cd06179 160 --IFNALALILLFFfyhpPPRPQlhgsstrqKLKRLDWVGLFLLIAGLVLFLLGLswggNPYPWS--SAHVIAPLVIGGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 236 AATLLYLWHARGNERALFSLRLF-NTRTFSLGLFgslCGRIGSGMLPFMT---PVFLQIGLGFSPFHAGLMMMPMVLGSM 311
Cdd:cd06179 236 LLIAFGLYEWKGTKDGLLPPRLLfRGRNFALILI---VAFVEGMIFYSLNifwPQQISLLFTTDPLKAGLYQLPFGLGTL 312
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-417 |
2.68e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 68.03 E-value: 2.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT-----AIVLFT 86
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 87 LGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWI 166
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 167 FLINLpVGIAGAAATLWLMPnytmqtrrfdfsgflllafgmaaltialdgyRSTGLSPAGLGALVAGGSAATLLYLWHAR 246
Cdd:cd06173 161 FAINA-LSFLLSALLLLFIR-------------------------------RPPPAAPGESSSLLLRDLREGLRYLRRSP 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 247 GNERALFSLRLFNTrtfslglfgslcgriGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGY 326
Cdd:cd06173 209 LLRLLLLALALFAL---------------LGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRR 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 327 RRVLVASTLALALVtllFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGV 406
Cdd:cd06173 274 GRLLLIGALLLGLA---LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
|
410
....*....|.
gi 495144450 407 SIAGLLLGAFG 417
Cdd:cd06173 351 LLAGLLADALG 361
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
12-203 |
4.81e-12 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 67.41 E-value: 4.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINL 171
Cdd:TIGR00710 87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLS 166
|
170 180 190
....*....|....*....|....*....|....*.
gi 495144450 172 PVGIAGAAATLWLMPNYTMQTRRF----DFSGFLLL 203
Cdd:TIGR00710 167 LAGILLSALIFFILPETLPYEARIqistYFETFLLL 202
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
49-186 |
6.01e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 60.36 E-value: 6.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 49 MVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVP 128
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 495144450 129 RDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVGIAGAAATLWLMP 186
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-187 |
3.96e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 61.44 E-value: 3.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 9 RWQLWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 89 SLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFL 168
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170
....*....|....*....
gi 495144450 169 INLPVGIAGAAATLWLMPN 187
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRD 182
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-186 |
1.76e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 59.16 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 32 ALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAARVLQGVG 111
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495144450 112 GAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVGIAGAAATLWLMP 186
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-187 |
2.50e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.71 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQ-------YMAAMTFVTLPGQVGPLLGPalggllvEYASWH 164
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKrgraiglVFSGLTLGLVLGRPLGGLLG-------QLLGWR 153
|
170 180
....*....|....*....|...
gi 495144450 165 WIFLINLPVGIAGAAATLWLMPN 187
Cdd:cd17324 154 AAFLAIAVLALLAALLLWRLLPS 176
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-445 |
9.87e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.17 E-value: 9.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 5 PQNVRWQLWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVL 84
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 85 FTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRD--QYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS 162
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETaaSRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 163 WHWIFLInlpvgiagaaatlwlmpnytmqtrrfdfSGFLLLAFGMAALTIALDGYRSTglspaglgalvaggsaatllyl 242
Cdd:COG0738 163 WHLPYLI----------------------------LAVLLLLLALLFLRSKLPEIEEE---------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 243 wHARGNERALFSLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMpMVLGSMGIKRIVVQ-VV 321
Cdd:COG0738 193 -EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLS-LFWGGMTIGRFLGGfLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 322 NRFGYRRVLVAStlaLALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMvmqls 401
Cdd:COG0738 271 KRFGPVRLLRLS---ALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM----- 342
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 495144450 402 MSLGVSIAGLLLGAFghnqlaADSGDAHGIFFWTYLCMALIIAL 445
Cdd:COG0738 343 GIVGGAIGPPLIGFL------ADAFGLRAAFLVPLVCYLLILLL 380
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
31-111 |
2.14e-08 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 56.18 E-value: 2.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 31 TALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAARVLQGV 110
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
.
gi 495144450 111 G 111
Cdd:PRK10473 104 G 104
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
20-422 |
2.47e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 55.73 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 20 FMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLN 99
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 100 ELVAARVLQGVGGAMMVPVGrltvmkivprdqyMAAMTFVTLPGQvgpllgpalggllveyaswhwifLINLPVGIAGAA 179
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNA-------------MALLGRTYPPGP-----------------------RKNIVFSLFGAT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 180 ATLwlmpnytmqtrrfdfsGFLL-LAFGMAALTIAldGYRSTGLSPAGLGALVAGGSaatllylwhargneralfslRLF 258
Cdd:cd17476 132 APL----------------GFALgGVFGGLFAQLA--WWPWIFWFLAILAAIVAVAA--------------------IFW 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 259 NTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASTLALA 338
Cdd:cd17476 174 TSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFL 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 339 LVTLLFMGVALAGWYWLLPVV-MLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLGAFG 417
Cdd:cd17476 254 VGPILFATMPVHQTYWAQAFPaMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTVETSVN 333
|
....*
gi 495144450 418 HNQLA 422
Cdd:cd17476 334 EDGAD 338
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
14-116 |
5.74e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.50 E-value: 5.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 14 IVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
Cdd:cd17359 5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
|
90 100
....*....|....*....|....*
gi 495144450 94 QSSTLNELVAARVLQG--VGGAMMV 116
Cdd:cd17359 85 FSPNFTIFIIARIIGGlaVGGASAL 109
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-171 |
6.21e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.50 E-value: 6.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINL 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
26-445 |
7.13e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 7.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 26 TTIVNTALPSMAAS-LGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAA 104
Cdd:cd17473 15 GAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 105 RVLQGVGGAMMVPVG------------RLTVMKIVPRDQYMAAMTFVTLPGQVGPLlgpalggllveyaSWHWIFLINLp 172
Cdd:cd17473 95 RALLGIGVAGIMTLAtaligdyfegeeRAKMLGLQSAAMSLGGVVFLLLGGALAEI-------------GWRAPFLVYL- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 173 vgiagaaatlwlmpnytmqtrrfdfSGFLLLAFGMAALTialdgyrstglSPAGLGALVAGGSAATllylwhargneral 252
Cdd:cd17473 161 -------------------------LALPVLILVLLFLP-----------EPARKSKSAASPGAAT-------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 253 fsLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVA 332
Cdd:cd17473 191 --AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 333 StlaLALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMvmqlSMSLGVSIAGLL 412
Cdd:cd17473 269 G---FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS----AFFLGQFLSPLV 341
|
410 420 430
....*....|....*....|....*....|...
gi 495144450 413 LGAFGHNqlaadSGDAHGIFFWTYLCMALIIAL 445
Cdd:cd17473 342 LGPLVNL-----TGGLSGAFLILGVLALVLAIV 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-422 |
8.49e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.97 E-value: 8.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 15 VAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQ 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 95 SSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEY--ASWHWIFLINLP 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 173 VGIAGAAATLWLMPNYTMQTRRFDFSGFLLlafgmaaltialdgyrstglspaglgalvaggsaatllylwhargnERAL 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSK----------------------------------------------SVLK 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 253 FSLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVA 332
Cdd:cd06174 195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 333 stLALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLL 412
Cdd:cd06174 275 --IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
410
....*....|
gi 495144450 413 LGAFGHNQLA 422
Cdd:cd06174 353 LAATFGLTGA 362
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
18-418 |
4.61e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 51.95 E-value: 4.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 18 GFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSST 97
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 98 LNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLinlpvgIAG 177
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFI------IEG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 178 AAATLWlmpnytmqtrrfdfsgflllafGMAALTIALDGYRSTGLSPAGLGALVAGGSAATLLYLwHARGNERALFSLRL 257
Cdd:TIGR00893 156 VLGIIW----------------------GVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGK-GPSTPKKYQIKELL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 258 FNTRTFSLGLfGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLM-MMPMVLGSMG---IKRIVVQVVNR---FGYRRVL 330
Cdd:TIGR00893 213 KDRRVWGLAL-GQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMaSLPGIVGFIGmilGGRLSDLLLRRgksLVFARKT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 331 VASTLALALVTLLFMGVALAGWYwllPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAG 410
Cdd:TIGR00893 292 AIIAGLVLSLLMFATNYVNIPYA---ALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIG 368
|
....*...
gi 495144450 411 LLLGAFGH 418
Cdd:TIGR00893 369 AIAATTGS 376
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
12-187 |
8.73e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.03 E-value: 8.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFM---QALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88
Cdd:cd17319 2 WRIIPLLFLAyviNYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 89 SLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFL 168
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170
....*....|....*....
gi 495144450 169 INLPVGIAGAAATLWLMPN 187
Cdd:cd17319 162 IEGLLGLLLAVLWWFYLRQ 180
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-450 |
2.36e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQAldtTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:cd17489 1 ILLANFFFFLSF---YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMtfvtlpgqvgpllgpalggllveyaSWHWIFlINL 171
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGI-------------------------GYYGLA-TTL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 172 PVGIaGAAATLWLMPNYtmqtrrfDFSGFLLLAFGMAALTIALDGYRSTGLSPAglgalvaggsaatllylwHARGNERA 251
Cdd:cd17489 132 AMAL-GPALGLFLYQHL-------GFAVLFIVAAVLALLALLLVFLVKDPPPVA------------------AEEAEAGT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 252 LFSLRLFNTRTFSLGLFGSLCGrIGSGMLPFMTPVFLqIGLGFSpfHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLV 331
Cdd:cd17489 186 RAFRRLVEKKVLPPALILFLAS-IAYGAISTFLPLYA-AERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVII 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 332 ASTLALALVtllFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGL 411
Cdd:cd17489 262 PGLLLLALG---LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGL 338
|
410 420 430
....*....|....*....|....*....|....*....
gi 495144450 412 LLGAFGhnqlaadsgdahgiFFWTYLCMALIIALPALVF 450
Cdd:cd17489 339 VAELFG--------------YRAMFLLAAVVVLLALVLY 363
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
10-327 |
2.42e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.66 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 10 WQLWIVAF-GFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88
Cdd:TIGR00895 16 WRAIILSFlIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 89 SLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFL 168
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 169 InlpvgiaGAAATLWLMPnytmQTRRF--DFSGFLLLAFGMAALTIALDGYRSTGLSPagLGALVAGGSAATLlylwhAR 246
Cdd:TIGR00895 176 V-------GGIAPLLLLL----LLMRFlpESIDFLVSKRPETVRRIVNAIAPQMQAEA--QSALPEQKSTQGT-----KR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 247 GNERALFSLRLfNTRTFSLGLfGSLCGRIGSGMLPFMTPvFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGY 326
Cdd:TIGR00895 238 SVFKALFQGKT-ARITVLLWL-LYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP 314
|
.
gi 495144450 327 R 327
Cdd:TIGR00895 315 R 315
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
17-185 |
2.92e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.30 E-value: 2.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 17 FGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSS 96
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 97 TLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLV-EYASWHWIFLINLPVGI 175
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaELYSWHWVFIVPGIIAI 161
|
170
....*....|
gi 495144450 176 AGAAATLWLM 185
Cdd:TIGR00881 162 IVSLICFLLL 171
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
16-118 |
3.17e-06 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 49.19 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 16 AFGFFMQALDTTIVNTALPSMAASLGESPL--RMHMVIVSY-VLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92
Cdd:cd17360 3 GIGGFLFGYDTGVISGALLYIKDDLGEVVLstGWQELIVSStVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVM 82
|
90 100
....*....|....*....|....*....
gi 495144450 93 AQSSTLNELVAARVLQGVG---GAMMVPV 118
Cdd:cd17360 83 AAAPNKEVLIVGRVLVGLGvgiASMTVPL 111
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
21-114 |
5.46e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 48.42 E-value: 5.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 21 MQALDTTIVNTALPSMAASLGESPlrMHMVIVSYVLTVAVMLPA--SGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTL 98
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDV--AQMGWAFSAGILGLLPGAllGGRLADRIGRKRILIVSVALFGLFSLATAQAWDF 103
|
90
....*....|....*...
gi 495144450 99 NELVAARVLQGV--GGAM 114
Cdd:PRK11551 104 PSLLVARLLTGVglGGAL 121
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-184 |
7.54e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 7.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 9 RWQLWIVAFGFFMQALDTTIVNTALPSMAASLGE-SPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTL 87
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 88 GSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF 167
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*..
gi 495144450 168 LINLPVGIAGAAATLWL 184
Cdd:cd17325 358 LAAAALLLLAAVLFLLL 374
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
27-135 |
1.46e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.21 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 27 TIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAARV 106
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110
....*....|....*....|....*....|...
gi 495144450 107 LQG----VGGAMmvpvgrltvMKIVPRDQYMAA 135
Cdd:PRK11652 105 IQGlgtgVGGVM---------ARTLPRDLYEGT 128
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
16-111 |
1.56e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.80 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 16 AFGFFMQALDTTIVNTALPSMAASLGE--SPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90
....*....|....*...
gi 495144450 94 QSSTLNELVAARVLQGVG 111
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLG 100
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
24-186 |
2.03e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.42 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 24 LDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVA 103
Cdd:cd17365 13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 104 ARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLInlpvgiaGAAATLW 183
Cdd:cd17365 93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL-------GGVPPLI 165
|
...
gi 495144450 184 LMP 186
Cdd:cd17365 166 LLP 168
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
195-466 |
2.21e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 195 FDFSGFLLLAFGMAALTIALDGYRSTGLSPAGL--GALVAGGSAATLLYLWHARGNERALFSLR-----LFNTRTFSLGL 267
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALifAVLGLLAFLLTFFGTKERPVPEEEKVSLKeslkaLLKNRPFLLLL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 268 FGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASTLALALVTLLFMgV 347
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-F 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 348 ALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGN-------SLLSMVMQLSMSLGVSIAGLLLGAFGHNQ 420
Cdd:COG2211 314 LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreglyfGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 495144450 421 LAADSGDA-HGIFFWTYLCMALIIALPALVFARVPDDISKNAVIARR 466
Cdd:COG2211 394 GAAQSPSAlTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
267-415 |
3.01e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.07 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 267 LFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASTLALALVtllFMG 346
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG---FAL 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495144450 347 VALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLGA 415
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
12-417 |
2.49e-04 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 43.08 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIF--FTAIVLFTLGS 89
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMigADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 90 LF---CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWI 166
Cdd:TIGR00900 81 LPfvaLLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 167 FLINLpVGIAGAAATLWLmpnytmqtrrfdfsgflllafgmaaltialdgyrstgLSPAGLGALVAGGSAatllylWHAR 246
Cdd:TIGR00900 161 IWVDA-VGFAISALLIVS-------------------------------------VRIPELAASEIQALS------NAVL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 247 GNERALFSLRLFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGy 326
Cdd:TIGR00900 197 RDTREGIKFVLKNPLLRTLLLLALLFNLVFAPAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFK- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 327 rRVLVASTLALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGV 406
Cdd:TIGR00900 276 -RMALMTGAIFVIGLAILVVGLTPPNFPLFLVLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGL 354
|
410
....*....|.
gi 495144450 407 SIAGLLLGAFG 417
Cdd:TIGR00900 355 ILAGPLADHLG 365
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
41-111 |
2.66e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.97 E-value: 2.66e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495144450 41 GESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAARVLQGVG 111
Cdd:cd17472 28 GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG 98
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-449 |
4.46e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLgESPLRMHMVIVSYVLTVAVMLPAS---GWLADRVGVRNIFFTAIVLFTLG 88
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-SLGLSLLQTGLLFAAGFLGRPIGAllfGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 89 SLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRdqymaamtfvtlpgqvgpllgpalggllvEYASWHWIFL 168
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPS-----------------------------KRRGFALGLL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 169 I-NLPVGIAGAAatlwlmpnytmqtrrfdfsgflLLAFGMAALTIALDGYRSTGLSPAGLGALVaggsaatlLYLWharg 247
Cdd:cd17316 131 QsGWALGALLAA----------------------LVASLLIPLLSGDWGWRILFLIGALPALLA--------LLLR---- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 248 neralfslrlfntRTFSLGLFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYR 327
Cdd:cd17316 177 -------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 328 RVLVASTLALALVTLLFMGVALAGWYWLLPVVMLFQGMVNSVrFSTMNTLTLRDLPDEMASSGNSllsmvmqLSMSLGVS 407
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGV-WGALYAYLAELFPTEVRATGVG-------LSYNLGRL 315
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 495144450 408 IAGLLLGAFGhnqLAADSGDAHGIFFWtYLCMALIIALPALV 449
Cdd:cd17316 316 GGGGAPPLIA---LLLASTGGTGVPAL-ILALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
12-187 |
1.04e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.13 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 92 CAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS----WHWIF 167
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLF 160
|
170 180
....*....|....*....|
gi 495144450 168 LinlpVGIAGAAATLWLMPN 187
Cdd:cd17371 161 L----LGALPALLVLFIRRF 176
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
12-140 |
1.10e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 12 LWIVAFGFFMQALDTTIVNTALPS-MAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSL 90
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFlLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 495144450 91 FCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAAMTFVT 140
Cdd:cd17473 279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-140 |
1.40e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 11 QLWIVAFGFFMQALDTTIVNTALPSMAAS-LGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGS 89
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495144450 90 L--FCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQ----------YMAAMTFVT 140
Cdd:COG2211 309 LllFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrreglYFGIFTFAI 371
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-452 |
2.16e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 9 RWQLWIVAFGFFMQALDTTIVNTA----LPSMAASLGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVL 84
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSvgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 85 FTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIVPRDQYMAaMTFVTLPGQVGPLLGPALGGLLVEYASWH 164
Cdd:COG2807 93 LAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLM-TGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 165 WIFLInlPVGIAGAAATLWLMpnytmQTRRfdfsgflllafgmaaltialdgyrstglSPAGLGALVAGGSAATLLylwh 244
Cdd:COG2807 172 GALAV--WALLALLALLLWLP-----LLRR----------------------------RPAAAAAAPAAASLRSLW---- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 245 argneralfslrlFNTRTFSLGLFGSLCGRIGSGMLPFMTPVFLQigLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRF 324
Cdd:COG2807 213 -------------RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD--AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 325 GYRRVLVAstLALALVTLLFMGVALAGWYWLLPVVMLFqGMVNSVRFSTMNTLTLRDLPD-EMASSGNSLLSMVMQLSMS 403
Cdd:COG2807 278 GDRRPLLL--LLGLLGLAGLLGLLLAPGSLPWLWAVLL-GLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAA 354
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 495144450 404 LGVSIAGLLLGAFGHNQLAadsgdahgifFWTYLCMALIIALPALVFAR 452
Cdd:COG2807 355 LGPLLVGALHDATGSWTAA----------LLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-417 |
2.41e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 267 LFGSLCGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASTLALALVTLLFMg 346
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL- 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495144450 347 vaLAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLGAFG 417
Cdd:pfam07690 81 --FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
48-195 |
2.44e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 40.31 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 48 HMVIVSYVLTVAVMLPASgWLADRVGVRNIFFTAIVLFTLGSLFCAQSSTLNELVAARVLQGVGGAMMVPVGRLTVMKIV 127
Cdd:cd17327 45 WGNTVFYVGYIIFELPGN-LLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495144450 128 PRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEY------ASWHWIFLINLPVGIAGAAATLWLMPNyTMQTRRF 195
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIEGLITIIIGLVIFFWLPD-NPSKAWF 196
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-258 |
4.34e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 4.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 20 FMQALDTTIVNTALPSMAAS---LGESPLRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAQSS 96
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVREfnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 97 TLNELVAARVLQGVGGAmMVPVGRLTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINLPVGIA 176
Cdd:cd17330 86 NLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 177 GAAATLWLMPNytmqTRRFDFSGFLL-LAFGMAALTIALDGYRSTGLSPAGLGALVAGGSAATLLYLW------HARGNE 249
Cdd:cd17330 165 NLVLVLFFLPP----LRRLLLVYFLIaLAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLlliprlAKRLGE 240
|
....*....
gi 495144450 250 RALFSLRLF 258
Cdd:cd17330 241 RKLLRLGLL 249
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
267-417 |
5.36e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 5.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 267 LFGSLCGRIGSGMLPFMTPvFLQIGLGFSPFHAGLMMMPMVLGSMGIKRIVVQVVNRFGYRRVLVASTLALALVTllfMG 346
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS---LL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495144450 347 VALAGWYWLLPVVMLFQGMVNSVRFSTMNTLTLRDLPDEMASSGNSLLSMVMQLSMSLGVSIAGLLLGAFG 417
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
14-231 |
5.63e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 14 IVAFGFFMQAldttiVNTALPSMAASLGESPlRMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
Cdd:pfam06609 53 VCATYFVLQA-----SASALPNILQDIGQSE-NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGC 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 94 QSSTLNELVAARVLQGVGGAmmvPVGR--LTVMKIVPRDQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINL 171
Cdd:pfam06609 127 TANKFNTLLAAMTLLGVAAG---PAGAspLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495144450 172 PVG-IAGAAATLWLMPNYTMQTR-----------RFDFSGFLLLAFGMAALTIAL----------DGYRSTGLSPAGLGA 229
Cdd:pfam06609 204 IMSaIAVLLIIIWYHPPSFAQLHgkkarkrdelaKLDWIGIFLVIAGTSLFLLGVswggkpnnpwNSAKIIGLISSGAGS 283
|
..
gi 495144450 230 LV 231
Cdd:pfam06609 284 LV 285
|
|
| |
