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Conserved domains on  [gi|495164886|ref|WP_007889684|]
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MULTISPECIES: sensor histidine kinase [Cronobacter]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
335-558 3.24e-71

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 232.07  E-value: 3.24e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 335 LFSSINRTLGEGIAQLLSAQILAGQYERQKQLLTQSEIKLLHAQVNPHFLFNALNTLMAVIRRDSDQACQLVQYLSTFFR 414
Cdd:COG3275  124 LLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 415 KNLKR-PTDVVSLADEIDHVNAYLQIEQARFQSHLQVSMNLPDELRHIRLPAFTLQPIVENAIKHGTSQLLGPGEIALRA 493
Cdd:COG3275  204 YSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISI 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495164886 494 SRDDDHLVLEIEDNAGLYQP--NAASNGLGMSLVDKRLRARFGDECGISVACEQDRFTRITLRLPLE 558
Cdd:COG3275  284 EVEGDRLVIEVENNGVGIQPkkKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLK 350
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 4.30e-47

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 162.35  E-value: 4.30e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886   27 TRLFIPLI-QVSIRLPHKLLCYVTFSCFCIMGTYFGLHIQ-DSIANTRAIGAVMGGLLGGPLVGGLVGLTGGLHRYSLGG 104
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  105 MTALSCMVSTIVEGLLGGIVHSWLIRRGRTdkiFNPFTAGAITLVAELVQMGIILLIARPFGDALHLVQNIAAPMVVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRRL---ISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 495164886  185 IGAAMFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 235-353 6.53e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 42.84  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  235 VAQVIRQEL-EIGAVAI------TDREQLLAFTGIGMDH-HLPGSPISSPWTLRAIESGEVVYADGNEVPYRCSLHP--N 304
Cdd:pfam13185   7 LLDAVLEAAvELGASAVgfillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 495164886  305 CKLGSTLVIPLRGENRkVVGTIKLYEPKHRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  87 AGLRSFLSVPLVSGGR-VVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
335-558 3.24e-71

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 232.07  E-value: 3.24e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 335 LFSSINRTLGEGIAQLLSAQILAGQYERQKQLLTQSEIKLLHAQVNPHFLFNALNTLMAVIRRDSDQACQLVQYLSTFFR 414
Cdd:COG3275  124 LLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 415 KNLKR-PTDVVSLADEIDHVNAYLQIEQARFQSHLQVSMNLPDELRHIRLPAFTLQPIVENAIKHGTSQLLGPGEIALRA 493
Cdd:COG3275  204 YSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISI 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495164886 494 SRDDDHLVLEIEDNAGLYQP--NAASNGLGMSLVDKRLRARFGDECGISVACEQDRFTRITLRLPLE 558
Cdd:COG3275  284 EVEGDRLVIEVENNGVGIQPkkKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLK 350
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 4.30e-47

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 162.35  E-value: 4.30e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886   27 TRLFIPLI-QVSIRLPHKLLCYVTFSCFCIMGTYFGLHIQ-DSIANTRAIGAVMGGLLGGPLVGGLVGLTGGLHRYSLGG 104
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  105 MTALSCMVSTIVEGLLGGIVHSWLIRRGRTdkiFNPFTAGAITLVAELVQMGIILLIARPFGDALHLVQNIAAPMVVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRRL---ISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 495164886  185 IGAAMFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 3.11e-37

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 133.33  E-value: 3.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 463 LPAFTLQPIVENAIKHGTSQLLGPGEIALRASRDDDHLVLEIEDNAGLYQPNA-------ASNGLGMSLVDKRLRARFGD 535
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTlarilirSSNGLGLNLVDKRLRQAFGN 80

                         90       100
                 ....*....|....*....|.
gi 495164886 536 ECGISVACEQDRFTRITLRLP 556
Cdd:cd16956   81 DYGLDIECAPGEGTRITIRLP 101
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-448 5.56e-28

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 106.76  E-value: 5.56e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495164886  370 SEIKLLHAQVNPHFLFNALNTLMAVIRRDSDQACQLVQYLSTFFRKNLKRPTDVVSLADEIDHVNAYLQIEQARFQSHL 448
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 453-558 1.24e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 58.81  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886   453 NLPDELRHIrlpaftLQPIVENAIKHGTSQllgpGEIALRASRDDDHLVLEIEDN------------------AGLYQPN 514
Cdd:smart00387   1 GDPDRLRQV------LSNLLDNAIKYTPEG----GRITVTLERDGDHVEITVEDNgpgippedlekifepffrTDKRSRK 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 495164886   515 AASNGLGMSLVDKRLRARFGDecgISVACEQDRFTRITLRLPLE 558
Cdd:smart00387  71 IGGTGLGLSIVKKLVELHGGE---ISVESEPGGGTTFTITLPLE 111
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 235-353 6.53e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 42.84  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  235 VAQVIRQEL-EIGAVAI------TDREQLLAFTGIGMDH-HLPGSPISSPWTLRAIESGEVVYADGNEVPYRCSLHP--N 304
Cdd:pfam13185   7 LLDAVLEAAvELGASAVgfillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 495164886  305 CKLGSTLVIPLRGENRkVVGTIKLYEPKHRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  87 AGLRSFLSVPLVSGGR-VVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
335-558 3.24e-71

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 232.07  E-value: 3.24e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 335 LFSSINRTLGEGIAQLLSAQILAGQYERQKQLLTQSEIKLLHAQVNPHFLFNALNTLMAVIRRDSDQACQLVQYLSTFFR 414
Cdd:COG3275  124 LLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 415 KNLKR-PTDVVSLADEIDHVNAYLQIEQARFQSHLQVSMNLPDELRHIRLPAFTLQPIVENAIKHGTSQLLGPGEIALRA 493
Cdd:COG3275  204 YSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISI 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495164886 494 SRDDDHLVLEIEDNAGLYQP--NAASNGLGMSLVDKRLRARFGDECGISVACEQDRFTRITLRLPLE 558
Cdd:COG3275  284 EVEGDRLVIEVENNGVGIQPkkKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLK 350
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
335-559 1.21e-60

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 207.18  E-value: 1.21e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 335 LFSSINRTLGEgIAQLLSaqilagQYERQKQLLTQSEIKLLHAQVNPHFLFNALNTL-MAVIRRDSDQACQLVQYLSTFF 413
Cdd:COG2972  214 LARSFNEMVER-IKELIE------EVYELELEKKEAELKALQAQINPHFLFNTLNSIrWLAELEDPEEAEEMLEALSKLL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 414 RKNLKRPTDVVSLADEIDHVNAYLQIEQARFQSHLQVSMNLPDELRHIRLPAFTLQPIVENAIKHGTSQLLGPGEIALRA 493
Cdd:COG2972  287 RYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISI 366

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495164886 494 SRDDDHLVLEIEDN-AGL-----------YQPNAASNGLGMSLVDKRLRARFGDECGISVACEQDRFTRITLRLPLEG 559
Cdd:COG2972  367 RKEGDRLVITVEDNgVGMpeekleklleeLSSKGEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEE 444
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 4.30e-47

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 162.35  E-value: 4.30e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886   27 TRLFIPLI-QVSIRLPHKLLCYVTFSCFCIMGTYFGLHIQ-DSIANTRAIGAVMGGLLGGPLVGGLVGLTGGLHRYSLGG 104
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  105 MTALSCMVSTIVEGLLGGIVHSWLIRRGRTdkiFNPFTAGAITLVAELVQMGIILLIARPFGDALHLVQNIAAPMVVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRRL---ISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 495164886  185 IGAAMFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 3.11e-37

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 133.33  E-value: 3.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 463 LPAFTLQPIVENAIKHGTSQLLGPGEIALRASRDDDHLVLEIEDNAGLYQPNA-------ASNGLGMSLVDKRLRARFGD 535
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTlarilirSSNGLGLNLVDKRLRQAFGN 80

                         90       100
                 ....*....|....*....|.
gi 495164886 536 ECGISVACEQDRFTRITLRLP 556
Cdd:cd16956   81 DYGLDIECAPGEGTRITIRLP 101
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 4.61e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 116.39  E-value: 4.61e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 463 LPAFTLQPIVENAIKHGTSQLLGPGEIALRASRDDDHLVLEIEDNAGLYQPNAAS---------NGLGMSLVDKRLRARF 533
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNilgkkpkegNGIGLYNVHQRLILLF 80

                         90       100
                 ....*....|....*....|...
gi 495164886 534 GDECGISVACEQDRFTRITLRLP 556
Cdd:cd16924   81 GEDYGIHIASEPDKGTRITFTIP 103
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-448 5.56e-28

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 106.76  E-value: 5.56e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495164886  370 SEIKLLHAQVNPHFLFNALNTLMAVIRRDSDQACQLVQYLSTFFRKNLKRPTDVVSLADEIDHVNAYLQIEQARFQSHL 448
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 453-558 1.24e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 58.81  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886   453 NLPDELRHIrlpaftLQPIVENAIKHGTSQllgpGEIALRASRDDDHLVLEIEDN------------------AGLYQPN 514
Cdd:smart00387   1 GDPDRLRQV------LSNLLDNAIKYTPEG----GRITVTLERDGDHVEITVEDNgpgippedlekifepffrTDKRSRK 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 495164886   515 AASNGLGMSLVDKRLRARFGDecgISVACEQDRFTRITLRLPLE 558
Cdd:smart00387  71 IGGTGLGLSIVKKLVELHGGE---ISVESEPGGGTTFTITLPLE 111
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
391-558 1.69e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 62.62  E-value: 1.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 391 LMAVIRRDSDQACQLVQYLSTFFR---KNLKRPTDVVSLADEIDHVNAYLQiEQARfQSHLQVSMNLPDELRHIRLPAFT 467
Cdd:COG0642  146 YLETILRSADRLLRLINDLLDLSRleaGKLELEPEPVDLAELLEEVVELFR-PLAE-EKGIELELDLPDDLPTVRGDPDR 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 468 LQPI----VENAIKHGTSQllgpGEIALRASRDDDHLVLEIEDN-AGL------------YQPNAASN----GLGMSLVd 526
Cdd:COG0642  224 LRQVllnlLSNAIKYTPEG----GTVTVSVRREGDRVRISVEDTgPGIppedlerifepfFRTDPSRRgggtGLGLAIV- 298

                        170       180       190
                 ....*....|....*....|....*....|...
gi 495164886 527 KRLRARFGdecG-ISVACEQDRFTRITLRLPLE 558
Cdd:COG0642  299 KRIVELHG---GtIEVESEPGKGTTFTVTLPLA 328
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 455-558 2.26e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 52.37  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  455 PDELRHIrlpaftLQPIVENAIKHGTSQllGPGEIALRasrDDDHLVLEIEDN-------------AGLYQPNAAS---N 518
Cdd:pfam02518   3 ELRLRQV------LSNLLDNALKHAAKA--GEITVTLS---EGGELTLTVEDNgigippedlprifEPFSTADKRGgggT 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 495164886  519 GLGMSLVdKRLRARFGDEcgISVACEQDRFTRITLRLPLE 558
Cdd:pfam02518  72 GLGLSIV-RKLVELLGGT--ITVESEPGGGTTVTLTLPLA 108
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
391-558 3.61e-08

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 54.53  E-value: 3.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 391 LMAVIRRDSDQACQLVQYLSTFFR-----KNLKR-PTDVVSLADE-IDHVNAYLQieqarfQSHLQVSMNLPDELRHIRL 463
Cdd:COG2205   55 LLEIIRESAERLLRLIEDLLDLSRlesgkLSLELePVDLAELLEEaVEELRPLAE------EKGIRLELDLPPELPLVYA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 464 PAFTLQPIV----ENAIKHGTSQllgpGEIALRASRDDDHLVLEIEDN-AGL------------YQPNAASN----GLGM 522
Cdd:COG2205  129 DPELLEQVLanllDNAIKYSPPG----GTITISARREGDGVRISVSDNgPGIpeeeleriferfYRGDNSRGeggtGLGL 204

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 495164886 523 SLVDKRLRARFGDecgISVACEQDRFTRITLRLPLE 558
Cdd:COG2205  205 AIVKRIVEAHGGT---IWVESEPGGGTTFTVTLPLA 237
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-540 8.65e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 50.15  E-value: 8.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 463 LPAFTLQPIVENAIKHGTSQLLGPGEIALRAS-RDDDHLVLEIEDNA---------GLYQPNAASNGLGMSLVDKRLRAR 532
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKkQLKNRLHIAVEDNGigispkvieRVEQDEMPGNKIGLLNVHQRLKLG 80


                 ....*...
gi 495164886 533 FGDECGIS 540
Cdd:cd16955   81 YGEGLHIR 88
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 354-559 2.41e-07

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 52.93  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 354 QILAGQYERQKQLltqseIKLLHAQVnpH-FLfNALNTLMAVIRRDSDQacQLVQYLSTFfRKNLKRPTDVVSLADEIDH 432
Cdd:COG3290  177 ERLEEELEGVKEL-----AEALRAQR--HdFR-NHLHTISGLLQLGEYD--EALEYIDEI-SEELQELIDSLLSRIGNPV 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 433 VNAYLQ--IEQARfQSHLQVSMNLPDELRHIRLPAFTLQPI----VENAIKHGTSQLLGPGEIALRASRDDDHLVLEIED 506
Cdd:COG3290  246 LAALLLgkAARAR-ERGIDLTIDIDSDLPDLPLSDTDLVTIlgnlLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVED 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495164886 507 N--------------AGLYQPNAASNGLGMSLVDKRLRARFGDecgISVACEQDRFTRITLRLPLEG 559
Cdd:COG3290  325 SgpgipeellekifeRGFSTKLGEGRGLGLALVKQIVEKYGGT---IEVESEEGEGTVFTVRLPKEG 388
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 422-558 1.06e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 48.36  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 422 DVVSLADEIDHVN--AYLQ-----IEQARFQSHLQVSMNLPDelrhIRLPAFTLQPI-------VENAIKHGtsqLLG-- 485
Cdd:COG3920  348 ELLYQSEDWEGVDlrDYLRellepLRDSYGGRGIRIELDGPD----VELPADAAVPLglilnelVTNALKHA---FLSge 420

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495164886 486 PGEIALRASRDDDHLVLEIEDN-AGL--YQPNAASNGLGMSLVDkrlraRFGDECGISVACEQDRFTRITLRLPLE 558
Cdd:COG3920  421 GGRIRVSWRREDGRLRLTVSDNgVGLpeDVDPPARKGLGLRLIR-----ALVRQLGGTLELDRPEGTRVRITFPLA 491
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 388-559 1.90e-05

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 47.26  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 388 LNTLMAVIRRDSDQACQLVQYLSTFFR--KNLKRPTDVVSLADEIdhVNAYlqiEQARFQSHLQVSMNLPDELRHIRLPA 465
Cdd:COG5000  241 LERALDTIIRQVDRLKRIVDEFLDFARlpEPQLEPVDLNELLREV--LALY---EPALKEKDIRLELDLDPDLPEVLADR 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 466 FTLQP----IVENAIKHgtsqLLGPGEIALRASRDDDHLVLEIEDN-AGLyqPNAASN--------------GLGMSLVD 526
Cdd:COG5000  316 DQLEQvlinLLKNAIEA----IEEGGEIEVSTRREDGRVRIEVSDNgPGI--PEEVLErifepffttkpkgtGLGLAIVK 389

                        170       180       190
                 ....*....|....*....|....*....|...
gi 495164886 527 KRLRARFGDecgISVACEQDRFTRITLRLPLEG 559
Cdd:COG5000  390 KIVEEHGGT---IELESRPGGGTTFTIRLPLAE 419
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
471-557 2.04e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 44.13  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 471 IVENAIKHGTsQLLGPGEIALRASRDDDHLVLEIEDN------AGLYQP--NAASNGLGMSLVDkrlraRFGDECGISva 542
Cdd:COG2172   42 AVTNAVRHAY-GGDPDGPVEVELELDPDGLEIEVRDEgpgfdpEDLPDPysTLAEGGRGLFLIR-----RLMDEVEYE-- 113

                         90
                 ....*....|....*
gi 495164886 543 cEQDRFTRITLRLPL 557
Cdd:COG2172  114 -SDPGGTTVRLVKRL 127
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
391-558 2.27e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 46.85  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 391 LMAVIRRDSDQACQLVQ---YLSTFFRKNLKRPTDVVSLADEIDHVNAYLQIEQARFQSHLQVSMNL--------PDELR 459
Cdd:COG5002  204 YLEIILEEAERLSRLVNdllDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEdpllvlgdPDRLE 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 460 HIrlpaftLQPIVENAIKHGTSQllgpGEIALRASRDDDHLVLEIEDN-AGL------------YQPNAASN------GL 520
Cdd:COG5002  284 QV------LTNLLDNAIKYTPEG----GTITVSLREEDDQVRISVRDTgIGIpeedlpriferfYRVDKSRSretggtGL 353

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 495164886 521 GMSLVdKRLRARFGdecG-ISVACEQDRFTRITLRLPLE 558
Cdd:COG5002  354 GLAIV-KHIVEAHG---GrIWVESEPGKGTTFTITLPLA 388
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
422-560 4.15e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 45.38  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 422 DVVSLADEIDHVnaylqIEQARFQSHLQVSMNLPDELRhiRLPA-------FTLQPIVENAIKHGtsqllGPGEIALRAS 494
Cdd:COG4585  121 DDLGLAAALEEL-----AERLLRAAGIRVELDVDGDPD--RLPPevelalyRIVQEALTNALKHA-----GATRVTVTLE 188

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495164886 495 RDDDHLVLEIEDN-AGLYQPNAASNGLGMSLVDKRLRARFGDecgISVACEQDRFTRITLRLPLEGT 560
Cdd:COG4585  189 VDDGELTLTVRDDgVGFDPEAAPGGGLGLRGMRERAEALGGT---LTIGSAPGGGTRVRATLPLAAA 252
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 235-353 6.53e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 42.84  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  235 VAQVIRQEL-EIGAVAI------TDREQLLAFTGIGMDH-HLPGSPISSPWTLRAIESGEVVYADGNEVPYRCSLHP--N 304
Cdd:pfam13185   7 LLDAVLEAAvELGASAVgfillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 495164886  305 CKLGSTLVIPLRGENRkVVGTIKLYEPKHRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  87 AGLRSFLSVPLVSGGR-VVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 6.72e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 42.03  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 463 LPAFTLQPIVENAIKHGTSQLLGPGEIALRASRDDDHLVLEIEDNA-GL---------YQPNAASNGLGMSLVD--KRLR 530
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGqGIpeerldllgKTTVTSEKGTGTALENlnRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 495164886 531 ARFGDECGISVACEQDRFTRITLRLP 556
Cdd:cd16957   81 GLFGSEACLHIESEVHGGTEVWFVIP 106
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 388-557 1.07e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 44.79  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 388 LNTLMAVIRRDSDQACQLVQYLSTFFRKNLKRPTdVVSLADEIDHVnayLQIEQARFQSH-LQVSMNLPDELRHIRLPAF 466
Cdd:COG4191  180 LREALERILEGAERAAEIVRSLRAFSRRDEEERE-PVDLNELIDEA---LELLRPRLKARgIEVELDLPPDLPPVLGDPG 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 467 TLQPIVEN-------AIKHGtsqllGPGEIALRASRDDDHLVLEIEDNAGLYQPNAASN---------------GLGMSL 524
Cdd:COG4191  256 QLEQVLLNllinaidAMEEG-----EGGRITISTRREGDYVVISVRDNGPGIPPEVLERifepffttkpvgkgtGLGLSI 330

                        170       180       190
                 ....*....|....*....|....*....|....
gi 495164886 525 VdKRLRARFGdecG-ISVACEQDRFTRITLRLPL 557
Cdd:COG4191  331 S-YGIVEKHG---GrIEVESEPGGGTTFTITLPL 360
GAF_3 pfam13492
GAF domain;
243-355 2.38e-04

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 41.20  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886  243 LEIGAVAITDREQLLAFTGIGMDHHLPGS---PISSPWTLRAIESGEVVYADGNEVpyrcslHPNCKLGSTLVIPLRGEn 319
Cdd:pfam13492  19 AERAAVYLLDEDGNKLQVAAGYDGEPDPSeslDADSPLARRALSSGEPISGLGSAG------EDGLPDGPALVVPLVAG- 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 495164886  320 RKVVGTIKLYEPKHRLFSSINRTLGEGIAQLLSAQI 355
Cdd:pfam13492  92 RRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAI 127
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-556 1.27e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.92  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 474 NAIKHGtsqllGPGEIALRASRDDDHLVLEIEDNAGLYQPNAASNGLGMSLVDKRLRAR-FGDECGISvaCEQDRFTRIT 552
Cdd:cd16917   11 NALKHA-----GASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAElLGGTLTIG--SRPGGGTRVT 83


                 ....
gi 495164886 553 LRLP 556
Cdd:cd16917   84 ARLP 87
GAF COG2203
GAF domain [Signal transduction mechanisms];
234-558 8.56e-03

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 39.02  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 234 KVAQVIRQELEIGAVAIT----DREQLLAFTGIGMDH-HLPGSPISSPWTLRAIESGEVV-----YADGNEVPYRCSLHP 303
Cdd:COG2203  214 RILELAGELLGADRGAILlvdeDGGELELVAAPGLPEeELGRLPLGEGLAGRALRTGEPVvvndaSTDPRFAPSLRELLL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 304 NCKLGSTLVIPLRGENRkVVGTIKLYEPKHRLFSSINRTLGEGIAQLLS-----AQILAGQYERQKQLLTQSEIKLLHAQ 378
Cdd:COG2203  294 ALGIRSLLCVPLLVDGR-LIGVLALYSKEPRAFTEEDLELLEALADQAAiaierARLYEALEAALAALLQELALLRLLLD 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 379 VNPHFLFNALNTLMAVIRRDSDQACQLVQYLSTFFRKNLKRPTDVVSLADEIDHVNAYLQIEQARFQSHLQVSMNLPDEL 458
Cdd:COG2203  373 LELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEG 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495164886 459 RHIRLPAFTLQPIVENAIKHGTSQLLGPGEIALRASRDDDHLVLEIEDNAGLYQPNAASNGLGMSLVDKRLRARFGDECG 538
Cdd:COG2203  453 LVLLLALAELELLEILELLVLLAVILLALALLAALLLLLLLLLALLALSALAVLASLLLALLLLLLLLLLLLLLGLLAAL 532

                        330       340
                 ....*....|....*....|
gi 495164886 539 ISVACEQDRFTRITLRLPLE 558
Cdd:COG2203  533 AADLLLLAAALLEDLLILLL 552
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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