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Conserved domains on  [gi|495357973|ref|WP_008082694|]
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phosphoribosylaminoimidazolesuccinocarboxamide synthase [Candidatus Aciduliprofundum boonei]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 11487020)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 6-298 4.92e-131

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


:

Pssm-ID: 237570  Cd Length: 341  Bit Score: 375.56  E-value: 4.92e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   6 KGKVKEVYALNDKE------LLFLFTDNISVFD-KIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSCEDS------ 72
Cdd:PRK13959   1 MGSVKDFYVDEEPTetdlgrGRFVFSDRYSVFDwGIMPDEIPDKGASLCTMGAYNFELLEEEGIKTHYIGVVEDgevvrl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  73 --------KMRVGRFRIINKPRIENE------------NYLIPLEFITRYYV--AGSLYERLKNGKMDYKLLGF--ESMP 128
Cdd:PRK13959  81 aeaseppnEMAVKLTQVPDLPFEGGSydydayheaageNYLIPLEVIFRNYVpvGSSLRDRIKEGKIKPEDLGLdaDEWP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 129 EYGEKLPEPYFEITTKFEAYDRKVSFEEAREIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREI 208
Cdd:PRK13959 161 EEGVKLPEPIVEFSTKYEEQDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEEREI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 209 YLVDTFGTLDEDRWwdkdAYERgkiVQLSKEFVRQYYRSIGYYEELKMAREEGKE------EPEIPPLPKDMVEKVSKLY 282
Cdd:PRK13959 241 RVVDVVGTFDENRF----SYEG---QELSKEVVRQYYRRTEWVEAVKEAKEEDVAdwrslcEPDPPPLPDEVVEAVSDLY 313

                        330
                 ....*....|....*.
gi 495357973 283 VEMYERITGRKLESGF 298
Cdd:PRK13959 314 KAGTNAYTGREWFDAP 329
 
Name Accession Description Interval E-value
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 6-298 4.92e-131

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 375.56  E-value: 4.92e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   6 KGKVKEVYALNDKE------LLFLFTDNISVFD-KIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSCEDS------ 72
Cdd:PRK13959   1 MGSVKDFYVDEEPTetdlgrGRFVFSDRYSVFDwGIMPDEIPDKGASLCTMGAYNFELLEEEGIKTHYIGVVEDgevvrl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  73 --------KMRVGRFRIINKPRIENE------------NYLIPLEFITRYYV--AGSLYERLKNGKMDYKLLGF--ESMP 128
Cdd:PRK13959  81 aeaseppnEMAVKLTQVPDLPFEGGSydydayheaageNYLIPLEVIFRNYVpvGSSLRDRIKEGKIKPEDLGLdaDEWP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 129 EYGEKLPEPYFEITTKFEAYDRKVSFEEAREIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREI 208
Cdd:PRK13959 161 EEGVKLPEPIVEFSTKYEEQDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEEREI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 209 YLVDTFGTLDEDRWwdkdAYERgkiVQLSKEFVRQYYRSIGYYEELKMAREEGKE------EPEIPPLPKDMVEKVSKLY 282
Cdd:PRK13959 241 RVVDVVGTFDENRF----SYEG---QELSKEVVRQYYRRTEWVEAVKEAKEEDVAdwrslcEPDPPPLPDEVVEAVSDLY 313

                        330
                 ....*....|....*.
gi 495357973 283 VEMYERITGRKLESGF 298
Cdd:PRK13959 314 KAGTNAYTGREWFDAP 329
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 3-291 1.56e-112

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 326.43  E-value: 1.56e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   3 LIRKGKVKEVYALNDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIgEMKIKNHYLSCEDSKM--RVGRFR 80
Cdd:cd01414    1 LIYSGKVRDVYDLGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELT-EDIIPNHLISTDVEDLpeIKEPED 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  81 IINKPRIENENYLIPLEFITRYYVAGSLYERLKNGKMDYkLLGFESMPEYGEKLPEPYFEITTKFE-AYDRKVSFEEARE 159
Cdd:cd01414   80 PDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVC-GIKLPEGLREAQKLPEPIFTPSTKAEeGHDENISFEEAVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 160 IGGlrQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFGTLDEDRWWDKDAYERGK-IVQLSK 238
Cdd:cd01414  159 IIG--AELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSYEPGKeQPSFDK 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 495357973 239 EFVRQYYRSIGYyeelkmareeGKEEPEIPPLPKDMVEKVSKLYVEMYERITG 291
Cdd:cd01414  237 QFVRDWLEASGW----------DKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-293 8.41e-75

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 229.20  E-value: 8.41e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   1 MQLIRKGKVKEVYALNDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSC-EDSKMRVGRF 79
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETlSGREMLVKKL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  80 RIInkprienenyliPLEFITRYYVAGSLYERLKNGKMDYklLGFEsmpeYGEKLPEPYFEITTKFEAY-DRKVSFEEAR 158
Cdd:COG0152   84 EMI------------PVEVVVRNYAAGSLWKRYQAGIALP--LGLE----EGTKLPEPIFEPSTKADEGhDPNISEEHIV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 159 EIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKDAYErgkivQLSK 238
Cdd:COG0152  146 ALGLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLWDADTYE-----SLDK 219

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495357973 239 EFVRQYYRSIgyyeelkmareegkeepeipplpkdmvekVSKLYVEMYERITGRK 293
Cdd:COG0152  220 DRFRDWLGGN-----------------------------TSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 3-244 5.46e-48

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 159.84  E-value: 5.46e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973    3 LIRKGKVKEVYAL-NDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYL-SCEDSKMRVGRFR 80
Cdd:pfam01259   1 LLYEGKVKDVYETdDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIkSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   81 IinkprienenylIPLEFITRYYVAGSLYERLKNgkmdykllgfesMPEyGEKLPEPYFEITTKFEAY-DRKVSFEEARE 159
Cdd:pfam01259  81 I------------IPLEVVVRNYAAGSLGKRLPG------------LKE-GTKLPEPIFEPSTKADALgDPNINEEHIVA 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  160 IGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKDAYERGKIvQLSKE 239
Cdd:pfam01259 136 LGLATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYEKSQE-SLDKD 213


                  ....*
gi 495357973  240 FVRQY 244
Cdd:pfam01259 214 RFRDD 218
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 2-254 2.43e-43

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 148.31  E-value: 2.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973    2 QLIRKGKVKEVYALNDKELL-FLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSC-EDSKMRVGRF 79
Cdd:TIGR00081   7 QKLYSGKAKDIYETDDPDLLrFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLiEDREMLVKKL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   80 RIinkprienenylIPLEFITRYYVAGSLYERLKngkmdykllgfesMPEyGEKLPEPYFEITTKFEAY-DRKVSFEEAR 158
Cdd:TIGR00081  87 DI------------IPLEVIVRNIAAGSLLKRLG-------------IPE-GLELEQPLVEFIFKPDEVgDPMLNESYAE 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  159 EIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKDAYERGKIVQLSK 238
Cdd:TIGR00081 141 ALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADEV-SPDTCRLWDKETYEVGAPKLDKD 219

                         250
                  ....*....|....*.
gi 495357973  239 EFVRQYYRSIGYYEEL 254
Cdd:TIGR00081 220 IFRRTLGKLIEAYETV 235
 
Name Accession Description Interval E-value
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 6-298 4.92e-131

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 375.56  E-value: 4.92e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   6 KGKVKEVYALNDKE------LLFLFTDNISVFD-KIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSCEDS------ 72
Cdd:PRK13959   1 MGSVKDFYVDEEPTetdlgrGRFVFSDRYSVFDwGIMPDEIPDKGASLCTMGAYNFELLEEEGIKTHYIGVVEDgevvrl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  73 --------KMRVGRFRIINKPRIENE------------NYLIPLEFITRYYV--AGSLYERLKNGKMDYKLLGF--ESMP 128
Cdd:PRK13959  81 aeaseppnEMAVKLTQVPDLPFEGGSydydayheaageNYLIPLEVIFRNYVpvGSSLRDRIKEGKIKPEDLGLdaDEWP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 129 EYGEKLPEPYFEITTKFEAYDRKVSFEEAREIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREI 208
Cdd:PRK13959 161 EEGVKLPEPIVEFSTKYEEQDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEEREI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 209 YLVDTFGTLDEDRWwdkdAYERgkiVQLSKEFVRQYYRSIGYYEELKMAREEGKE------EPEIPPLPKDMVEKVSKLY 282
Cdd:PRK13959 241 RVVDVVGTFDENRF----SYEG---QELSKEVVRQYYRRTEWVEAVKEAKEEDVAdwrslcEPDPPPLPDEVVEAVSDLY 313

                        330
                 ....*....|....*.
gi 495357973 283 VEMYERITGRKLESGF 298
Cdd:PRK13959 314 KAGTNAYTGREWFDAP 329
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 3-291 1.56e-112

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 326.43  E-value: 1.56e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   3 LIRKGKVKEVYALNDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIgEMKIKNHYLSCEDSKM--RVGRFR 80
Cdd:cd01414    1 LIYSGKVRDVYDLGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELT-EDIIPNHLISTDVEDLpeIKEPED 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  81 IINKPRIENENYLIPLEFITRYYVAGSLYERLKNGKMDYkLLGFESMPEYGEKLPEPYFEITTKFE-AYDRKVSFEEARE 159
Cdd:cd01414   80 PDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVC-GIKLPEGLREAQKLPEPIFTPSTKAEeGHDENISFEEAVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 160 IGGlrQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFGTLDEDRWWDKDAYERGK-IVQLSK 238
Cdd:cd01414  159 IIG--AELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSYEPGKeQPSFDK 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 495357973 239 EFVRQYYRSIGYyeelkmareeGKEEPEIPPLPKDMVEKVSKLYVEMYERITG 291
Cdd:cd01414  237 QFVRDWLEASGW----------DKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-293 8.41e-75

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 229.20  E-value: 8.41e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   1 MQLIRKGKVKEVYALNDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSC-EDSKMRVGRF 79
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETlSGREMLVKKL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  80 RIInkprienenyliPLEFITRYYVAGSLYERLKNGKMDYklLGFEsmpeYGEKLPEPYFEITTKFEAY-DRKVSFEEAR 158
Cdd:COG0152   84 EMI------------PVEVVVRNYAAGSLWKRYQAGIALP--LGLE----EGTKLPEPIFEPSTKADEGhDPNISEEHIV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 159 EIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKDAYErgkivQLSK 238
Cdd:COG0152  146 ALGLATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLWDADTYE-----SLDK 219

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495357973 239 EFVRQYYRSIgyyeelkmareegkeepeipplpkdmvekVSKLYVEMYERITGRK 293
Cdd:COG0152  220 DRFRDWLGGN-----------------------------TSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 3-244 5.46e-48

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 159.84  E-value: 5.46e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973    3 LIRKGKVKEVYAL-NDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYL-SCEDSKMRVGRFR 80
Cdd:pfam01259   1 LLYEGKVKDVYETdDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIkSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   81 IinkprienenylIPLEFITRYYVAGSLYERLKNgkmdykllgfesMPEyGEKLPEPYFEITTKFEAY-DRKVSFEEARE 159
Cdd:pfam01259  81 I------------IPLEVVVRNYAAGSLGKRLPG------------LKE-GTKLPEPIFEPSTKADALgDPNINEEHIVA 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  160 IGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKDAYERGKIvQLSKE 239
Cdd:pfam01259 136 LGLATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYEKSQE-SLDKD 213


                  ....*
gi 495357973  240 FVRQY 244
Cdd:pfam01259 214 RFRDD 218
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-294 9.51e-48

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 161.52  E-value: 9.51e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   1 MQLIRKGKVKEVYALNDKELLFLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMkIKNHYLScEDSKMRV---- 76
Cdd:PRK13961  12 LPLLGRGKVRDIYAVDDDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAHI-VPNHLTG-IDVDDVVpade 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  77 -----GRFRIINKPRIenenylIPLEFITRYYVAGSlyerlknGKMDYKLLGF---ESMPE---YGEKLPEPYFEITTKF 145
Cdd:PRK13961  90 adqvlGRAVVVKKLKP------LPVECVVRGYLTGS-------GWKDYQATGTvcgIKLPAglvEASKLPEPIFTPATKA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 146 E--AYDRKVSFEEAREIGGLRQSeiEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFGTLDEDRWW 223
Cdd:PRK13961 157 ElgDHDENISFEEVVELVGAELA--AQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEVLTPDSSRFW 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495357973 224 DKDAYERGKiVQLS--KEFVRQYYRSIGYyeelkmareeGKEEPEiPPLPKDMVEKVSKLYVEMYERITGRKL 294
Cdd:PRK13961 235 PADSYQPGT-SQPSfdKQFVRDWLETSGW----------DKTAPA-PPLPADVIEKTRAKYREALERLTGKSL 295
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 6-295 1.46e-47

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 161.21  E-value: 1.46e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   6 KGKVKEVYALNDKELLFLFTDNISVFDKIIPSkIPRKGETLCKSAAFWFEKIGEMkIKNHYLSCEDSKMRVGRfriinkp 85
Cdd:PRK12607  20 RGKVRDNYDLPDGRRVMVATDRISAFDRVLPA-IPYKGQVLNQTAAFWFEATKDI-CPNHVLAVPDPNVVVGK------- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  86 RIEnenyLIPLEFITRYYVAGSLYERLKNGKMDYKLLGF-ESMPEyGEKLPEPYFEITTKFE--AYDRKVSFEEAREIGG 162
Cdd:PRK12607  91 RCE----PFPVEMVVRGYLAGSTWRLYKAGKREMYGVTLpDGLRE-NQKLPEPIITPTTKAEegGHDEPISPEEILAQGL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 163 LRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFGTLDEDRWWDKDAYE----RGKI-VQLS 237
Cdd:PRK12607 166 LTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIHTPDSSRYWYADGYEerfaAGEPqEQLD 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 495357973 238 KEFVRQYYrsigyyeelkmAREEGKEEPEIPPLPKDMVEKVSKLYVEMYERITGRKLE 295
Cdd:PRK12607 246 KEFVRQWL-----------IERCGPYGQEIPEIPDEVIVSVSERYIELYEKITGETFV 292
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 2-254 2.43e-43

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 148.31  E-value: 2.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973    2 QLIRKGKVKEVYALNDKELL-FLFTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSC-EDSKMRVGRF 79
Cdd:TIGR00081   7 QKLYSGKAKDIYETDDPDLLrFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLiEDREMLVKKL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   80 RIinkprienenylIPLEFITRYYVAGSLYERLKngkmdykllgfesMPEyGEKLPEPYFEITTKFEAY-DRKVSFEEAR 158
Cdd:TIGR00081  87 DI------------IPLEVIVRNIAAGSLLKRLG-------------IPE-GLELEQPLVEFIFKPDEVgDPMLNESYAE 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  159 EIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKDAYERGKIVQLSK 238
Cdd:TIGR00081 141 ALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADEV-SPDTCRLWDKETYEVGAPKLDKD 219

                         250
                  ....*....|....*.
gi 495357973  239 EFVRQYYRSIGYYEEL 254
Cdd:TIGR00081 220 IFRRTLGKLIEAYETV 235
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 5-295 1.28e-37

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 136.88  E-value: 1.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   5 RKGKVKEVYALNDKeLLFLFTDNISVFDKIIPSkIPRKGETLCKSAAFWFEKIGEMkIKNHYLSCEDSKMRVGRfriinK 84
Cdd:PLN02544  79 RRGKVRDIYDLGDY-LVLVTTDRQSAFDRVLAS-IPFKGQVLNQTSAWWFNNTKHI-TPNALVSSPDPNVTIAK-----K 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  85 PRIenenylIPLEFITRYYVAGS----LYERLKNGKMDYklLGfESMPE---YGEKLPEPYFEITTKFEAYDRKVSFEEA 157
Cdd:PLN02544 151 CSV------FPVEFVVRGYMTGStstsLWTVYNKGVRNY--CG-NDLPDgmvKNQKLPANILTPTTKAADHDVPISPEEI 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 158 REIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFGTLDEDRWWDKDAYE----RGKI 233
Cdd:PLN02544 222 VEEGLMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDEVHTPDSSRYWLADSYEerhaAGLE 301

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495357973 234 VQ-LSKEFVRQYYRSigyyeelkmaREEGKEEPEIPPLPKDMVEKVSKLYVEMYERITGRKLE 295
Cdd:PLN02544 302 PEnIDKEFLRLWFKE----------NCDPYKDEVLPEAPAELVCELSWRYIKLYETITGEKFE 354
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-226 8.74e-21

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 88.62  E-value: 8.74e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   1 MQLIRKGKVKEVYALNDKELLFL-FTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSC-EDSKMRVGR 78
Cdd:PRK09362   4 KELLYEGKAKIVYSTDDPDLLIVeFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKlSDREQLVKK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  79 FRIinkprienenylIPLEFITRYYVAGSLYERlkngkmdyklLGFESmpeyGEKLPEPYFEITTKFEAY-DRKVSFEEA 157
Cdd:PRK09362  84 VEI------------IPLEVVVRNVAAGSLVKR----------LGIEE----GTVLPPPIVEFYYKNDALgDPMINEDHI 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495357973 158 REIGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDKD 226
Cdd:PRK09362 138 LALGWATPEELAEIKELALKINDVLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEI-SPDTCRLWDKE 205
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 3-225 3.16e-19

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 84.43  E-value: 3.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   3 LIRKGKVKEVYALNDKELLFL-FTDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLS-CEDSKMRVGRFR 80
Cdd:cd01415    1 LLYEGKAKIVYATDDPDVLIVeFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEkLSDREQLVKKVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  81 IInkprienenyliPLEFITRYYVAGSLYERlkngkmdyklLGFESmpeyGEKLPEPYFEITTKFEAY-DRKVSFEEARE 159
Cdd:cd01415   81 II------------PLEVVVRNIAAGSLVKR----------LGIEE----GTVLDPPIVEFYYKNDELgDPLINEDHILA 134

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495357973 160 IGGLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGEGREIYLVDTFgTLDEDRWWDK 225
Cdd:cd01415  135 LGLATEEELKEIKELALKINEVLSEFFAEIGIILVDFKLEFGRDKDGEIVLADEI-SPDTCRLWDK 199
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 7-295 8.22e-14

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 70.89  E-value: 8.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   7 GKVKEVYALNDKE------------------LLFLFTDNISVFDKIIPSK-----IPRKGETLCKSAAFWFEKIGEMKI- 62
Cdd:PRK13960  25 GKVRSVYWLTEEDsrrlikekgynvpadaplAIMVISDRISAFDCIWHGEgglngVPGKGAALNAISNHWFKLFKENGLa 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  63 KNHYLSCEDSKMRvgrfrIINKPRIenenylIPLEFITRYYVAGSLYERLKNGKMDYKLLGFESMPEYGEKLPEPYFEIT 142
Cdd:PRK13960 105 DSHILDIPHPFVW-----IVQKARP------VMIEAICRQYITGSMWRAYSKGEREFCGITLPEGLEKDQKLPELLITPS 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 143 TKF---------EAYDRKVS---FEEAREIGGLRQSEIEEIRELILKVD-EIITNEVGKRGLLHVDGKKEFAF-----GE 204
Cdd:PRK13960 174 TKGiltgipgvpEADDVNISrsdIEANYQAFNFSSADDIDLYEKLLKEGfKVISDALAKLDQIFVDTKFEFGYvtdaaGN 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973 205 GREIYLvDTFGTLDEDRWWDKDAYERGKIVQLSKEFVRQYYrsIGYYEE----LKMAREEGKEE-PEIPPLPKDMVEKVS 279
Cdd:PRK13960 254 EKLIYM-DEVGTPDSSRIWDGAAYRDGKIVENSKEGFRQFL--LNHFPDpdilLNKDRMPEREAlARDNALPLEAMMDVS 330

                        330
                 ....*....|....*.
gi 495357973 280 KLYVEMYERITGRKLE 295
Cdd:PRK13960 331 RTYTGIAEKITGAKIV 346
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 2-222 5.04e-06

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 46.90  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973   2 QLIRKGKVKEVYALNDKELLFLF--TDNISVFDKIIPSKIPRKGETLCKSAAFWFEKIGEMKIKNHYLSCEDSKMRVGRf 79
Cdd:cd01416    5 KKLIEGKTKIVYELPDQPGLVLIqsKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIAR- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495357973  80 riinkpRIEnenyLIPLEFITRYYVAGSLYERlkngkmdykllgFESMPEyGEKLPEPYFEITTKFEA-YDRKVSFEEAR 158
Cdd:cd01416   84 ------KCE----MIPIEWVCRRIATGSFLKR------------NPGVKE-GYRFSPPKLEFFYKDDAnHDPQWSEEQLL 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495357973 159 E----IGGLR--QSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFG-EGREIYLVDtfgTLDEDRW 222
Cdd:cd01416  141 EaklnCGGLKigKKEVDIMTKSTIAIFEILEKAWATQDCTLVDMKIEFGVDvTTGEILLAD---VIDNDSW 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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