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Conserved domains on  [gi|495387749|ref|WP_008112452|]
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MULTISPECIES: pyruvate kinase [Pseudoalteromonas]

Protein Classification

pyruvate kinase( domain architecture ID 11481784)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

EC:  2.7.1.40
Gene Ontology:  GO:0006096|GO:0004743|GO:0000287|GO:0030955
PubMed:  2379684|12798932|10751408

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-467 0e+00

pyruvate kinase; Provisional


:

Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 701.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDAKmEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGIN 160
Cdd:PRK05826  82 GKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 161 RLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGS-NAQLLAKIERAEAVEtqeAVDDIILA 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVD---NIDEIIEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 240 SDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETA 319
Cdd:PRK05826 238 SDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 320 AGDYPEETVATMARVCLGAESQKETHVSKHRLDSRFSSNAESIALSAMYAANHLDSVKAIITLTESGSTAKLMSRISSGL 399
Cdd:PRK05826 318 AGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGA 397

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495387749 400 PIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIG 467
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
 
Name Accession Description Interval E-value
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-467 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 701.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDAKmEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGIN 160
Cdd:PRK05826  82 GKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 161 RLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGS-NAQLLAKIERAEAVEtqeAVDDIILA 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVD---NIDEIIEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 240 SDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETA 319
Cdd:PRK05826 238 SDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 320 AGDYPEETVATMARVCLGAESQKETHVSKHRLDSRFSSNAESIALSAMYAANHLDSVKAIITLTESGSTAKLMSRISSGL 399
Cdd:PRK05826 318 AGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGA 397

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495387749 400 PIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIG 467
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-477 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 689.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:COG0469    1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDakMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGIN 160
Cdd:COG0469   81 GPVELKKGDTFTLT--TDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 161 RLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVEtqeAVDDIILAS 240
Cdd:COG0469  159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVE---NLDEIIEAS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 241 DAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 320
Cdd:COG0469  236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 321 GDYPEETVATMARVCLGAESQKETHVSKHRL-DSRFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRISSGL 399
Cdd:COG0469  316 GKYPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDLG-AKAIVAFTESGSTARRISRYRPKV 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495387749 400 PIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNTMKIVTV 477
Cdd:COG0469  395 PILALTPNERTARRLALVWGVYPVLVDDVE-STDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 2-477 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 569.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   2 LRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEG 81
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  82 -KVTLSVGAKFILDAKMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHL-VHTIVTVGGVLSNNKGI 159
Cdd:cd00288   81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 160 NRLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETQeavDDIILA 239
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF---DEILEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 240 SDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETA 319
Cdd:cd00288  238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 320 AGDYPEETVATMARVCLGAESQKETHVSKHRLD---SRFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRIS 396
Cdd:cd00288  318 KGKYPVEAVKAMARICLEAEKALSHRVLFNEMRrltPRPTSTTEAVAMSAVRAAFELG-AKAIVVLTTSGRTARLVSKYR 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 397 SGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKCE----KDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETiGATNTM 472
Cdd:cd00288  397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPGwqedTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTM 475


                 ....*
gi 495387749 473 KIVTV 477
Cdd:cd00288  476 RILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 3-474 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 546.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749    3 RRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEGK 82
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   83 VTLSVGAKFILDAKMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGINRL 162
Cdd:TIGR01064  81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  163 GGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAG-SNAQLLAKIERAEAVETqeaVDDIILASD 241
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  242 AVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 321
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  322 DYPEETVATMARVCLGAESQKETHV-SKHRLDS--RFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRISSG 398
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTnFNDRKNSdpKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPN 396

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495387749  399 LPIYSLSRHASTLGQTALYRGVYPVFFDSTKCEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNTMKI 474
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 2-340 1.67e-141

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 409.84  E-value: 1.67e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749    2 LRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEG 81
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   82 K--VTLSVGAKFI--LDAKMeKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESV-EGHLVHTIVTVGGVLSNN 156
Cdd:pfam00224  81 KkdIELKAGDEMIvsTDAKY-KGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  157 KGINRLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETqeaVDDI 236
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNN---FDEI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  237 ILASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSA 316
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316

                         330       340
                  ....*....|....*....|....
gi 495387749  317 ETAAGDYPEETVATMARVCLGAES 340
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEK 340
 
Name Accession Description Interval E-value
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-467 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 701.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDAKmEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGIN 160
Cdd:PRK05826  82 GKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 161 RLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGS-NAQLLAKIERAEAVEtqeAVDDIILA 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVD---NIDEIIEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 240 SDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETA 319
Cdd:PRK05826 238 SDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 320 AGDYPEETVATMARVCLGAESQKETHVSKHRLDSRFSSNAESIALSAMYAANHLDSVKAIITLTESGSTAKLMSRISSGL 399
Cdd:PRK05826 318 AGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGA 397

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495387749 400 PIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIG 467
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-477 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 689.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:COG0469    1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDakMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGIN 160
Cdd:COG0469   81 GPVELKKGDTFTLT--TDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 161 RLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVEtqeAVDDIILAS 240
Cdd:COG0469  159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVE---NLDEIIEAS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 241 DAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 320
Cdd:COG0469  236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 321 GDYPEETVATMARVCLGAESQKETHVSKHRL-DSRFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRISSGL 399
Cdd:COG0469  316 GKYPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDLG-AKAIVAFTESGSTARRISRYRPKV 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495387749 400 PIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNTMKIVTV 477
Cdd:COG0469  395 PILALTPNERTARRLALVWGVYPVLVDDVE-STDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 2-477 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 569.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   2 LRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEG 81
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  82 -KVTLSVGAKFILDAKMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHL-VHTIVTVGGVLSNNKGI 159
Cdd:cd00288   81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 160 NRLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETQeavDDIILA 239
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF---DEILEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 240 SDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETA 319
Cdd:cd00288  238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 320 AGDYPEETVATMARVCLGAESQKETHVSKHRLD---SRFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRIS 396
Cdd:cd00288  318 KGKYPVEAVKAMARICLEAEKALSHRVLFNEMRrltPRPTSTTEAVAMSAVRAAFELG-AKAIVVLTTSGRTARLVSKYR 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 397 SGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKCE----KDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETiGATNTM 472
Cdd:cd00288  397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPGwqedTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTM 475


                 ....*
gi 495387749 473 KIVTV 477
Cdd:cd00288  476 RILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 3-474 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 546.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749    3 RRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEGK 82
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   83 VTLSVGAKFILDAKMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGINRL 162
Cdd:TIGR01064  81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  163 GGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAG-SNAQLLAKIERAEAVETqeaVDDIILASD 241
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  242 AVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 321
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  322 DYPEETVATMARVCLGAESQKETHV-SKHRLDS--RFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRISSG 398
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTnFNDRKNSdpKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPN 396

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495387749  399 LPIYSLSRHASTLGQTALYRGVYPVFFDSTKCEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNTMKI 474
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK06247 PRK06247
pyruvate kinase; Provisional
 1-478 1.04e-147

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 430.50  E-value: 1.04e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:PRK06247   3 RNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDakMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGIN 160
Cdd:PRK06247  83 GKVQLANGQTFRLD--VDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 161 RLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAeaaGSNAQLLAKIERAEAVEtqeAVDDIILAS 240
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII---GGRVPVMAKIEKPQAID---RLEAIVEAS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 241 DAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 320
Cdd:PRK06247 235 DAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETAS 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 321 GDYPEETVATMARVCLGAES----QKETHVSKHRLDsrfSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRIS 396
Cdd:PRK06247 315 GKYPVEAVRTMARIIRQVERdptyPPLIHAQRPQPE---ATKRDAISYAARDIAERLD-LAALVAYTSSGDTALRAARER 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 397 SGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNTMKIVT 476
Cdd:PRK06247 391 PPLPILALTPNPETARRLALTWGVHCVVVDDAR-DTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAY 469


                 ..
gi 495387749 477 VS 478
Cdd:PRK06247 470 IG 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 2-340 1.67e-141

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 409.84  E-value: 1.67e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749    2 LRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEG 81
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   82 K--VTLSVGAKFI--LDAKMeKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESV-EGHLVHTIVTVGGVLSNN 156
Cdd:pfam00224  81 KkdIELKAGDEMIvsTDAKY-KGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  157 KGINRLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETqeaVDDI 236
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNN---FDEI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  237 ILASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSA 316
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316

                         330       340
                  ....*....|....*....|....
gi 495387749  317 ETAAGDYPEETVATMARVCLGAES 340
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEK 340
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-478 8.60e-135

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 401.23  E-value: 8.60e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   1 MLRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKE 80
Cdd:PRK06354   6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFED 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDAKMEKGQGDINAVgiDYKELPQDVAPGDLLLLNDGLIQLTVESV--EGHLVHTIVTVGGVLSNNKG 158
Cdd:PRK06354  86 GPIELKTGDEFILTSREVLGTQEKFSV--TYDGLADEVPVGSRILLDDGLIELEVEEVdkADGELHCKVLVGGVLSNKKG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 159 INRLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEA-AGSNAQLLAKIERAEAVETqeaVDDII 237
Cdd:PRK06354 164 VNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEhNGKHIPIIAKIEKQEAIDN---IDAIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 238 LASDAVMVARGDLGVEIG--DAALMgkQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLS 315
Cdd:PRK06354 241 ELCDGLMVARGDLGVEIPaeEVPLL--QKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLS 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 316 AETAAGDYPEETVATMARVCLGAESQKETHVSKHRLDSRFSSNAESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRI 395
Cdd:PRK06354 319 NETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLD-AAAIVTLTKSGATARNVSKY 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 396 SSGLPIYSLSRHASTLGQTALYRGVYPVFFD---STkcekDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNTM 472
Cdd:PRK06354 398 RPKTPILAVTPNESVARRLQLVWGVTPLLVLdapST----DETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLM 473


                 ....*.
gi 495387749 473 KIVTVS 478
Cdd:PRK06354 474 KVHVVG 479
PRK09206 PRK09206
pyruvate kinase PykF;
2-474 1.80e-112

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 340.11  E-value: 1.80e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   2 LRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEG 81
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  82 K-VTLSVGAKFIL--DAKMekgQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKG 158
Cdd:PRK09206  81 NdVSLKAGQTFTFttDKSV---VGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 159 INRLGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRS-LAEAAGSNAQLLAKIERAEAVETqeaVDDII 237
Cdd:PRK09206 158 VNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREhLKAHGGENIQIISKIENQEGLNN---FDEIL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 238 LASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAE 317
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 318 TAAGDYPEETVATMARVClgaesQKETHVSKHRLDSRFSSN----AESIALSAMYAANHLDSvKAIITLTESGSTAKLMS 393
Cdd:PRK09206 315 SAKGKYPLEAVSIMATIC-----ERTDRVMNSRLESNNDNRklriTEAVCRGAVETAEKLDA-PLIVVATQGGKSARSVR 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 394 RISSGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKCEKDSMVKdALSTLVAAGSLQAGDTVIITHGDAMETiGATNTMK 473
Cdd:PRK09206 389 KYFPDATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRL-GKELALQSGLAQKGDVVVMVSGALVPS-GTTNTAS 466


                 .
gi 495387749 474 I 474
Cdd:PRK09206 467 V 467
PLN02461 PLN02461
Probable pyruvate kinase
 4-477 1.39e-105

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 323.85  E-value: 1.39e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   4 RTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEGK- 82
Cdd:PLN02461  22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKp 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  83 VTLSVGAKFIL--DAKMEkgqGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVES--VEGHLVHTIVTVGGVLSNNKG 158
Cdd:PLN02461 102 VQLKQGQEITIttDYSIK---GDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGERKN 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 159 INRLGGGLTAPAFTEKDKEDLItaaEIGV----DYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKieraeaVETQEAV- 233
Cdd:PLN02461 179 VNLPGVVVDLPTLTEKDKEDIL---QWGVpnkiDFIALSFVRKGSDLVEVRKVLGEHAKSILLISK------VENQEGLd 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 234 --DDIILASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDA 311
Cdd:PLN02461 250 nfDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDC 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 312 VMLSAETAAGDYPEETVATMARVCLGAESQKE-THVSKHRLDSRFS--SNAESIALSAMYAANhldSVKA--IITLTESG 386
Cdd:PLN02461 330 VMLSGETAAGAYPELAVKTMARICREAEASLDyGALFKEIMRSAPLpmSPLESLASSAVRTAN---KVKAslIVVLTRGG 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 387 STAKLMSRISSGLPIYSL-------------SRHASTLGQTALYRGVYPVFFDSTKCEKDS-----MVKDALSTLVAAGS 448
Cdd:PLN02461 407 TTARLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSesteeILEAAIEHAKKKGL 486

                        490       500
                 ....*....|....*....|....*....
gi 495387749 449 LQAGDTVIithgdAMETIGATNTMKIVTV 477
Cdd:PLN02461 487 CKPGDSVV-----ALHRIGGASVIKILTV 510
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 3-477 1.80e-97

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 302.84  E-value: 1.80e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   3 RRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDiATKLGKH--IAILADLQGPKIRVSTFKE 80
Cdd:PTZ00066  38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE-AAKARPNanLGILLDTKGPEIRTGFLKN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GK-VTLSVGA--KFILDAKMEkgqGDINAVGIDYKELPQDVAPGDLLLLNDGLiqLTVESVEGHLVHTIVTV--GGVLSN 155
Cdd:PTZ00066 117 HKpITLKEGQtlKITTDYTFL---GDETCISCSYKKLPQSVKVGNIILIADGS--LSCKVLEVHDDYIITKVlnNATIGE 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 156 NKGINRLGGGLTAPAFTEKDKEDLIT-AAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETqeaVD 234
Cdd:PTZ00066 192 RKNMNLPGVKVELPVIGEKDKNDILNfAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLIN---FD 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 235 DIILASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVML 314
Cdd:PTZ00066 269 EILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVML 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 315 SAETAAGDYPEETVATMARVCLGAESQKETHVSKHRLDSRFS---SNAESIALSAMYAANHLDSvKAIITLTESGSTAKL 391
Cdd:PTZ00066 349 SGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPtpvSVQEAVARSAVETAEDINA-KLIIALTETGNTARL 427

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 392 MSRISSGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDALSTLVAAGSLQAGDTVIITHGDAMETIGATNT 471
Cdd:PTZ00066 428 ISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQ-GTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNL 506


                 ....*.
gi 495387749 472 MKIVTV 477
Cdd:PTZ00066 507 MKVVKI 512
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 30-478 4.96e-87

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 274.24  E-value: 4.96e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  30 NVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEGKVTLSVGAKFIL--DAKMEKgQGDINAV 107
Cdd:PTZ00300   2 SVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVttDPAFAD-KGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 108 GIDYKELPQDVAPGDLLLLNDGLIQLTVESVEG-HLVHTIVTVGGVLSNNKGINRLGGGLTAPAFTEKDKEDLITAAEIG 186
Cdd:PTZ00300  81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDeQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 187 VDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETqeaVDDIILASDAVMVARGDLGVEIGDAALMGKQKLI 266
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQN---IDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 267 IRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGDYPEETVATMARVCLGAESQKETHV 346
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 347 ---SKHRLDSRFSSNAESIALSAMYAANHLDSvKAIITLTESGSTAKLMSRISSGLPIYSLSRHASTLGQTALYRGVYPV 423
Cdd:PTZ00300 318 ffnSIKKLQPIPMSAEEAVCSSAVNSVYETKA-KALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESV 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495387749 424 FFDSTKCEKDSMVKDALSTLV----AAGSLQAGDTVIITHGDaMETIGATNTMKIVTVS 478
Cdd:PTZ00300 397 FFDAERLGHDEGKEQRVAMGVgfakSKGYVQSGDLMVVVHAD-HKVKGYANQTRIILVS 454
PRK06739 PRK06739
pyruvate kinase; Validated
 8-343 1.34e-81

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 256.80  E-value: 1.34e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   8 VATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRdiatKLGKHIAILADLQGPKIRVSTFKEGKVTLSV 87
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVK----SLDDSIKILGDVQGPKIRLGEIKGEQITLQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  88 GAKFILDAkmEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGINRLGGGLT 167
Cdd:PRK06739  82 GDSFILHT--QPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 168 APAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNA-QLLAKIERAEAVETqeaVDDIILASDAVMVA 246
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIEN---FQDICKEADGIMIA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 247 RGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGDYPEE 326
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316

                        330
                 ....*....|....*..
gi 495387749 327 TVATMARVCLGAESQKE 343
Cdd:PRK06739 317 SVSTLRLVSEFAEHVKK 333
PLN02623 PLN02623
pyruvate kinase
 3-457 8.61e-73

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 240.60  E-value: 8.61e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   3 RRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDI-ATKLGKHIAILADLQGPKIRVSTFKEg 81
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYnAQSKDNVIAIMLDTKGPEVRSGDLPQ- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  82 KVTLSVGAKFILDAKmeKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVLSNNKGINR 161
Cdd:PLN02623 189 PIMLEEGQEFTFTIK--RGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNV 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 162 LGGGLTAPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQLLAKIERAEAVETQEAvddIILASD 241
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHS---IITASD 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 242 AVMVARGDLGVE--IGDAALMgkQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGTDAVMLSAETA 319
Cdd:PLN02623 344 GAMVARGDLGAElpIEEVPLL--QEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETA 421

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 320 AGDYPEETVATMARVCLGAESQKETHVSKHRLDSRFSSN-AESIALSAMYAANHLDSvkAIITLTESGSTAKLMSRISSG 398
Cdd:PLN02623 422 HGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHmSEMFAFHATMMANTLGT--SIIVFTRTGFMAILLSHYRPS 499

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495387749 399 LPIYSLSRHASTLGQTALYRGVYPVFFDSTKCEKDSMVKdALSTLVAAGSLQAGDTVII 457
Cdd:PLN02623 500 GTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFAR-ALSLLLNKGMVKEGEEVAL 557
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 2-457 6.17e-68

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 225.78  E-value: 6.17e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   2 LRRTKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFK-E 80
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGgA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  81 GKVTLSVGAKFILDAKMEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESVEGHLVHTIVTVGGVL------- 153
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLlpranlt 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 154 --SNNKGINRLGGGLtaPAFTEKDKEDLITAAEIGVDYIAVSFPRSGDDMRYVRSLAEAAGSNAQL--LAKIERAEAVET 229
Cdd:PLN02762 184 fwRDGSLVRERNAML--PTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDSDIgvIAKIESLDSLKN 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 230 qeaVDDIILASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVMDVANAVLDGT 309
Cdd:PLN02762 262 ---LEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 310 DAVMLSAETAAGDYPEETVATMARVCLGAE--SQKETH---VSKHRLDSRFSSN-AESIALSAMYAANHLdSVKAIITLT 383
Cdd:PLN02762 339 DALMLSGESAMGLYPEKALSVLRSVSLRMElwSREEKRheaLELPQLSSSLSDRiSEEICNSAAKMANNL-GVDAIFVYT 417

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495387749 384 ESGSTAKLMSRISSGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKCEKDSMVKdALSTLVAAGSLQAGDTVII 457
Cdd:PLN02762 418 KHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNK-TFSLLKARGMIKSGDLVIA 490
PLN02765 PLN02765
pyruvate kinase
 5-477 4.45e-61

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 207.98  E-value: 4.45e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   5 TKIVATLGPATDRDNNLEKIIRAGANVVRLNFSHGVAQDHKDRAQAVRDIATKLGKHIAILADLQGPKIRVSTFKEGKVT 84
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  85 LSVGAKFILDAKMEKGQGDiNAVGIDYKELPQDVAPGDL--------LLLNDGLIQLTVESVEGHLVHTIV----TVGGV 152
Cdd:PLN02765 110 LKAGNTVTLTPDQSKEASS-EVLPINFPGLAKAVKPGDTifvgqylfTGSETTSVWLEVDEVKGDDVVCTVknsaTLAGS 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 153 L----SNNKGINrlgggltAPAFTEKDKEDLIT-AAEIGVDYIAVSFPRSGDDMRYVRS-LAEAAGSNAQLLAKIERAEA 226
Cdd:PLN02765 189 LftlhVSQVRID-------LPTLSEKDKEVISTwGVPNKIDFLSLSYTRHAEDVREAREfLSSLGLSQTQIFAKIENVEG 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 227 VETqeaVDDIILASDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTaTQMMESMIDNPMPTRAEVMDVANAVL 306
Cdd:PLN02765 262 LTH---FDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVL 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 307 DGTDAVMLSAETAAGDYPEETVATMARVCLGAES--QKETH---VSKHRLDSRfsSNAESIALSAMYAANhldSVKA--I 379
Cdd:PLN02765 338 DGADAILLGAETLRGLYPVETISTVGRICAEAEKvfNQDLYfkkTVKYVGEPM--SHLESIASSAVRAAI---KVKAsvI 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 380 ITLTESGSTAKLMSRISSGLPIYSL--------SRHASTLG-----QTALYRGVYPVFFD------STKCEKDSMVKDAL 440
Cdd:PLN02765 413 IVFTSSGRAARLIAKYRPTMPVLSVviprlktnQLKWSFTGafqarQCLIVRGLFPMLADprhsaeSTSATNESVLKVAL 492

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 495387749 441 STLVAAGSLQAGDTVIIthgdaMETIGATNTMKIVTV 477
Cdd:PLN02765 493 DHGKAAGVIKSHDRVVV-----CQKVGDSSVVKIIEL 524
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 360-475 1.57e-39

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 138.38  E-value: 1.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  360 ESIALSAMYAANHLDsVKAIITLTESGSTAKLMSRISSGLPIYSLSRHASTLGQTALYRGVYPVFFDSTKcEKDSMVKDA 439
Cdd:pfam02887   1 EAIAHAAVEAAEELG-AKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAE-TTDEMLRRA 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 495387749  440 LSTLVAAGSLQAGDTVIITHGDAMETIGATNTMKIV 475
Cdd:pfam02887  79 VKVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
PRK08187 PRK08187
pyruvate kinase; Validated
 3-334 9.14e-31

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 124.36  E-value: 9.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749   3 RRTKIVATLGP--ATDRDNNLEkIIRAGANVVRLNFSHgvaqDHKDRAQA----VRDIATKLGKHIAILADLQGPKIRVS 76
Cdd:PRK08187 133 RRTRIMVTLPSeaADDPDFVLR-LAERGMDCARINCAH----DDPAAWQAmighLRQAERATGRRCKILMDLAGPKIRTG 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749  77 TF--KEGKVTLSVGAKFILDAK--MEKGQGDINAVGIDYKELPQDVAPGDLLLLNDGLIQLTVESV-EGHLVHTIVTV-- 149
Cdd:PRK08187 208 AVagPLGKTRLYTGDRLALVAQgpPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVgPGGALLEVTHArp 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 150 -GGVLSNNKGINRLGGGLTAPAFTEKDKEDLITAAEiGVDYIAVSFPRSGDDMRYVRS-LAEAAGSNAQ---LLAKIERA 224
Cdd:PRK08187 288 kGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSPGDVEALQAaLAARRPDDWRklgLVLKIETP 366

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 225 EAVEtqeAVDDIILASD-----AVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMMESMIDNPMPTRAEVM 299
Cdd:PRK08187 367 RAVA---NLPELIVQAAgrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMT 443

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 495387749 300 DVANAvlDGTDAVMLSaetaAGDYPEETVATMARV 334
Cdd:PRK08187 444 DAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
PRK14725 PRK14725
pyruvate kinase; Provisional
 135-314 2.32e-22

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 100.41  E-value: 2.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 135 VESVEGHLVHTIVT---VGGV-LSNNKGINRLGGGLTAPAFTEKDKEDLITAAEIGvDYIAVSFPRSGDDMRYV-RSLAE 209
Cdd:PRK14725 390 VVKVEADEVELRITharPGGSkLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLlDALEK 468

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495387749 210 AAGSNAQLLAKIERAEAVETqeaVDDIILA-----SDAVMVARGDLGVEIGDAALMGKQKLIIRRARSLNRTVVTATQMM 284
Cdd:PRK14725 469 LGADDLGVVLKIETRRAFEN---LPRILLEamrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVL 545

                        170       180       190
                 ....*....|....*....|....*....|
gi 495387749 285 ESMIDNPMPTRAEVMDVANAVLdgTDAVML 314
Cdd:PRK14725 546 ESLAKKGLPSRAEITDAAMALR--AECVML 573
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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