|
Name |
Accession |
Description |
Interval |
E-value |
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
25-489 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 680.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 25 GIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEEIPVLPDENMqvseskpVFIRVKDSADALGKSLSAWY 104
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAAGV-------PVIVVPDPRAALALLAAAFY 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 105 ENPSDNLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLLSTVCNYIDGEAIPTDHTTPDPVTLHNLMARMVDAGCEYAFM 184
Cdd:COG0769 74 GHPSQKLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVTHVVM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 185 EVSSHSIDQKRISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYS 264
Cdd:COG0769 154 EVSSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAPARVITYG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 265 LRTLADFKGKILESHFEGTEMLVNG----REVMTRFVGRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQTIQ 340
Cdd:COG0769 234 LKADADLRATDIELSADGTRFTLVTpggeVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 341 SPLGYTAIVDYAHTPDALTNVLSGIHEVldGNGRVITVVGCGGNRDKGKRPIMAKEAAKLSDQLILTSDNPRFEEPDEII 420
Cdd:COG0769 314 GGQGPTVIVDYAHTPDALENVLEALRPH--TKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDPAAII 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495421465 421 KDMVAGLNAADmeRTLCITDRAQAIKTATMLARKGDVILVAGKGHEDYQEVKGVKHHFDDREQLKEIFK 489
Cdd:COG0769 392 ADILAGIPGAG--KVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDREVAREALA 458
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
1-489 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 642.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 1 MELKELIhplevlevvgnADVEISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEEiPVLPDENMqvs 80
Cdd:PRK00139 4 MKLRDLL-----------APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEA-DGEAGTGV--- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 81 eskpVFIRVKDSADALGKSLSAWYENPSDNLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLLSTVCNYIDGEAIPTDHT 160
Cdd:PRK00139 69 ----PVIIVPDLRKALALLAAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 161 TPDPVTLHNLMARMVDAGCEYAFMEVSSHSIDQKRISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLpaSAFA 240
Cdd:PRK00139 145 TPDALDLQRLLAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSEL--GLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 241 LTNADDKSGLVMLQNTAAKKLTYslrTLADFKGKILESHFEGTEMLVNGrEVMTRFVGRFNAYNLLAVYGAAVSLGKDPE 320
Cdd:PRK00139 223 VINADDEVGRRLLALPDAYAVSM---AGADLRATDVEYTDSGQTFTLVT-EVESPLIGRFNVSNLLAALAALLALGVPLE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 321 EVLVVLSDLHSVSGRFQTIQSPLGYTAIVDYAHTPDALTNVLSGIHEVLdgNGRVITVVGCGGNRDKGKRPIMAKEAAKL 400
Cdd:PRK00139 299 DALAALAKLQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHA--KGRLICVFGCGGDRDKGKRPLMGAIAERL 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 401 SDQLILTSDNPRFEEPDEIIKDMVAGLNAAdmertlcITDRAQAIKTATMLARKGDVILVAGKGHEDYQEVKGVKHHFDD 480
Cdd:PRK00139 377 ADVVIVTSDNPRSEDPAAIIADILAGIYDV-------IEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIPFDD 449
|
....*....
gi 495421465 481 REQLKEIFK 489
Cdd:PRK00139 450 REVAREALA 458
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
20-481 |
1.17e-172 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 493.76 E-value: 1.17e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 20 DVEISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEeipvlpDENMQVSESKPVfIRVKDSADALGKS 99
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVE------RDVDFYVAPVPV-IIVPDLRHALSSL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 100 LSAWYENPSDNLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLLSTVCNYIDGEAI---PTDHTTPDPVTLHNLMARMVD 176
Cdd:TIGR01085 74 AAAFYGHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLiknPAALTTPEALTLQSTLAEMVE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 177 AGCEYAFMEVSSHSIDQKRISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLqNT 256
Cdd:TIGR01085 154 AGAQYAVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFV-KR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 257 AAKKLTYSLRTL------ADFKGKILESHFEGTEMLV----NGREVMTRFVGRFNAYNLLAVYGAAVSLGK-DPEEVLVV 325
Cdd:TIGR01085 233 LPKDITVSAITQpadgraQDIKITDSGYSFEGQQFTFetpaGEGHLHTPLIGRFNVYNLLAALATLLHLGGiDLEDIVAA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 326 LSDLHSVSGRFQTIQSPLGYTAIVDYAHTPDALTNVLSGIHEVLDgnGRVITVVGCGGNRDKGKRPIMAKEAAKLSDQLI 405
Cdd:TIGR01085 313 LEKFRGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKD--GRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVI 390
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495421465 406 LTSDNPRFEEPDEIIKDMVAGLNaaDMERTLCITDRAQAIKTATMLARKGDVILVAGKGHEDYQEVKGVKHHFDDR 481
Cdd:TIGR01085 391 LTSDNPRGEDPEQIIADILAGIS--EKEKVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGETIPFDDR 464
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
1-485 |
3.45e-159 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 476.12 E-value: 3.45e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 1 MELKELIHPLEVLEVVGNADveiSGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEEIPVlpdenMQVS 80
Cdd:PRK11929 10 VKLEELLQALAWLRGCVAAT---ADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGE-----DQVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 81 ESKPVFIRVKDSADALGKSLSAWYENPSDNLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLLSTVCNYIDGEAIPTDHT 160
Cdd:PRK11929 82 AADALVLPVADLRKALGELAARWYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGRLIPGSLT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 161 TPDPVTLHNLMARMVDAGCEYAFMEVSSHSIDQKRISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFA 240
Cdd:PRK11929 162 TPDAIILHRILARMRAAGADAVAMEASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 241 LTNADDKSGLVMLQ--NTAAKKLTYSLRTLADFK---------GKILESHFEGTEMlvngrEVMTRFVGRFNAYNLLAVY 309
Cdd:PRK11929 242 VINADDPAAARLLAalPRGLKVGYSPQNAGADVQardlratahGQVFTLATPDGSY-----QLVTRLLGRFNVSNLLLVA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 310 GAAVSLGKDPEEVLVVLSDLHSVSGRFQ------TIQSPLgytAIVDYAHTPDALTNVLSGIHEVL-DGNGRVITVVGCG 382
Cdd:PRK11929 317 AALKKLGLPLAQIARALAAVSPVPGRMErvgptaGAQGPL---VVVDYAHTPDALAKALTALRPVAqARNGRLVCVFGCG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 383 GNRDKGKRPIMAKEAAKLSDQLILTSDNPRFEEPDEIIKDMVAGLNAADmeRTLCITDRAQAIKTATMLARKGDVILVAG 462
Cdd:PRK11929 394 GDRDKGKRPEMGRIAAELADRVVVTSDNPRSEAPEAIIDQILAGIPAGA--RVFVISDRAEAIRQAIWMAAPGDVILIAG 471
|
490 500
....*....|....*....|...
gi 495421465 463 KGHEDYQEVKGVKHHFDDREQLK 485
Cdd:PRK11929 472 KGHETYQEIGGRKLFFDDREWAR 494
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
20-475 |
2.38e-78 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 252.65 E-value: 2.38e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 20 DVEISGIQSDSRKVEKGFLFVAVRGTAvdGHAYIQSAIEKGAAAIVCE---EIPVlpdenmqvseskPVFIrVKDSADAL 96
Cdd:PRK14022 31 GVQFDDISYDSRTADEGTLFFAKGAYF--KHKFLQNAITQGLKLYVSEkdyEVGI------------PQVI-VPDIKKAM 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 97 GKSLSAWYENPSDNLILVGVTGTNGKTTIATLLYEMFRKmGHKVGLLSTVCNYIDGEAIPTDH-TTPDPVTLHNLMARMV 175
Cdd:PRK14022 96 SLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQ-LHKPAMLSTMNTTLDGETFFKSAlTTPESLDLFKMMAEAV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 176 DAGCEYAFMEVSSHSIDQKRISGLSFNGGIFTNLTRDHLDY--HKTVENYLKAKKKFFDDlpaSAFALTNAD-DKSGLVM 252
Cdd:PRK14022 175 DNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHKRLLMEN---SKAVVVNSDmDHFSELL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 253 LQNTAAKKLTYSLRTLADFKGKILEShFEGTEMLVNGREVmtRFVGRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDlHSV 332
Cdd:PRK14022 252 EQVTPQEHDFYGIDSENQIMASNAFS-FEATGKLAGTYDI--QLIGKFNQENAMAAGLACLRLGASLEDIQKGIAQ-TPV 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 333 SGRFQTIQSPLGYTAIVDYAHTPDALTNVLSGIHEVLDgnGRVITVVGCGGNRDKGKRPIMAKEAAKLSD-QLILTSDNP 411
Cdd:PRK14022 328 PGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQK--GKLILLLGAAGNKGESRRPDFGRVANRHPYlQVILTADDP 405
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495421465 412 RFEEPDEIIKDMVAGLNaadmeRTL-CITDRAQAIKTATMLA-RKGDVILVAGKGHEDYQEVKGVK 475
Cdd:PRK14022 406 NNEDPKMITQEIASHIT-----HPVeIIDDRAEAIKHAMSITeGPGDAVIIAGKGADAYQIVPGHR 466
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
116-312 |
1.13e-63 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 205.23 E-value: 1.13e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 116 VTGTNGKTTIATLLYEMFRKMGhkvGLLSTVCNYIDgeaiPTDHTTPDPVTLHNLMARMVDAGCEYAFMEVSSHSIDQKR 195
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAG---GVIGTIGTYIG----KSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 196 ISGL-SFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLV---MLQNTAAKKLTYSLRTLADF 271
Cdd:pfam08245 74 LSGLlKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFliaKLKKAGVRVITYGIEGEADL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 495421465 272 KGKILESHFEGTE---MLVNGR--EVMTRFVGRFNAYNLLAVYGAA 312
Cdd:pfam08245 154 RAANIELSSDGTSfdlFTVPGGelEIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
14-464 |
1.22e-51 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 181.45 E-value: 1.22e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 14 EVVGNADVEISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEEipvlpdenmQVSESKPVfIRVKDSA 93
Cdd:COG0770 15 RLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSR---------PLPADLPL-IVVDDTL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 94 DALGKsLSAWYENPSdNLILVGVTGTNGKTTIATLLYEMFRKMG--HK--------VGLlstvcnyidgeaiptdhttpd 163
Cdd:COG0770 85 KALQQ-LAAAHRARF-NIPVIAITGSNGKTTTKEMLAAVLSTKGkvLAtpgnfnneIGV--------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 164 PVTLhnlmARMvDAGCEYAFMEVS-SHsidQKRISGLSF----NGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASA 238
Cdd:COG0770 142 PLTL----LRL-PEDHEFAVLEMGmNH---PGEIAYLARiarpDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 239 FALTNADDKSGLVMLQNTAAKKLTYSLRTLADFKGKILESHFEGTEMLVN----GREVMTRFVGRFNAYNLLAVYGAAVS 314
Cdd:COG0770 214 VAVLNADDPLLAALAERAKARVLTFGLSEDADVRAEDIELDEDGTRFTLHtpggELEVTLPLPGRHNVSNALAAAAVALA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 315 LGKDPEEVLVVLSDLHSVSGRFQTIQSPLGYTAIVD-YAHTPDALT---NVLSGihevLDGNGRVITVVGC----GGNRD 386
Cdd:COG0770 294 LGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDsYNANPDSMKaalDVLAQ----LPGGGRRIAVLGDmlelGEESE 369
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495421465 387 KGKRPImAKEAAKLS-DQLILtsdnprfeepdeIIKDMVAGLNAADMERTLCITDRAQAIKTATMLARKGDVILVagKG 464
Cdd:COG0770 370 ELHREV-GELAAELGiDRLFT------------VGELARAIAEAAGGERAEHFEDKEELLAALKALLRPGDVVLV--KG 433
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
29-462 |
6.25e-35 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 135.09 E-value: 6.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 29 DSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEEiPVLPDENMQVseskpvfIRVKDSADALGKSLSAWYENps 108
Cdd:TIGR01143 2 DSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDR-EVGPDNGLPQ-------ILVDDTLEALQALARAKRAK-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 109 DNLILVGVTGTNGKTTIATLLYEMFRkmgHKVGLLSTVCNYIDGEAIPtdhttpdpvtlhnLMARMVDAGCEYAFMEVS- 187
Cdd:TIGR01143 72 FSGKVIGITGSSGKTTTKEMLAAILS---HKYKVFATPGNFNNEIGLP-------------LTLLRAPGDHDYAVLEMGa 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 188 SHsidQKRISGLSF----NGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTA-AKKLT 262
Cdd:TIGR01143 136 SH---PGEIAYLAEiakpDIAVITNIGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPnRNILS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 263 YSLRTlADFKGKIL---ESHFEGTEMLVNGREVMTR--FVGRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQ 337
Cdd:TIGR01143 213 FGFEG-GDFVAKDIsysALGSTSFTLVAPGGEFEVSlpLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 338 tIQSPLGYTAIVD-YAHTPDALtnvLSGIHEVLDGNGRVITVVG----CGGNRDKGKRPIMAKEAAKLSDQLILTSDNPR 412
Cdd:TIGR01143 292 -VQTKNGLTLIDDtYNANPDSM---RAALDALARFPGKKILVLGdmaeLGEYSEELHAEVGRYANSLGIDLVFLVGEEAA 367
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495421465 413 ------------FEEPDEIIKDMVAglnaadmertlcitdraqaiktatmLARKGDVILVAG 462
Cdd:TIGR01143 368 viydsfgkqgkhFADKDELLAFLKT-------------------------LVRKGDVVLVKG 404
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
114-459 |
6.30e-33 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 129.82 E-value: 6.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 114 VGVTGTNGKTTIATLLYEMFRKMGHKVGL--------LSTVCNYIDGEAIptdhttpdpvtlhnlmarmVdagceyafME 185
Cdd:COG0771 108 IAITGTNGKTTTTTLIGHILKAAGLRVAVggnigtplLDLLLEPEPPDVY-------------------V--------LE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 186 VSSHSIDqkRISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYSL 265
Cdd:COG0771 161 LSSFQLE--TTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPFSL 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 266 RTLADFkgkilESHFEGtEMLV---NGREVMT----RFVGRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQT 338
Cdd:COG0771 239 KEPLEG-----GAGLED-GKLVdraSGEELLPvddlRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEF 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 339 IQSPLGytaiVDY-----AHTPDALTNVLSGihevLDGNGRVItvvgCGGnRDKGK-----RPIMAKEAAKLsdqLILTS 408
Cdd:COG0771 313 VAEING----VRFindskATNPDATLAALES----FDGPVVLI----AGG-LDKGAdfsplAPAVAERVKAV---VLIGE 376
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 495421465 409 DNPRFEEpdEIIKDMVAGLNAADMErtlcitdraQAIKTATMLARKGDVIL 459
Cdd:COG0771 377 DAEKIAA--ALAGAGVPVVIVETME---------EAVAAAAELARPGDVVL 416
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
113-461 |
1.74e-32 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 128.61 E-value: 1.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 113 LVGVTGTNGKTTIATLLYEMFRKMGHKVGLlstvCNYIDgeaiptdhtTPdpvtlhnLMARMVDAGCEYAFMEVSSHSID 192
Cdd:TIGR01087 104 VVAITGTNGKTTTTSLLYHLLKAAGLKAFL----GGNIG---------TP-------ALEVLDQEGAELYVLELSSFQLE 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 193 qkRISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYSLRTLADFK 272
Cdd:TIGR01087 164 --TTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKDAERG 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 273 GKILeshfegTEMLV-NGREVMTRFVGRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQTIQSPLGYTAIVDy 351
Cdd:TIGR01087 242 LCIR------DGGLYlKPNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYND- 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 352 ahtpDALTNVLSGIHEVLDGNGRVITVVgcgGNRDKGK-----RPIMAKEAAKLsdqLILTSDNPrfeepdEIIKDmvag 426
Cdd:TIGR01087 315 ----SKATNVHATLAALSAFDNPVILIV---GGDDKGAdfsplAPAAAGKVKAV---LAIGEDAA------KIAPL---- 374
|
330 340 350
....*....|....*....|....*....|....*
gi 495421465 427 LNAADMERTLCiTDRAQAIKTATMLARKGDVILVA 461
Cdd:TIGR01087 375 LKEAGLSVYLV-ESLEEAVQAAREVASPGDVVLLS 408
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
114-464 |
1.69e-29 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 120.17 E-value: 1.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 114 VGVTGTNGKTTIATLLYEMFRKMGHKvgllstvCNYIDGeAIPTDHttpdpvtlhNLMARMVDA------GCEY--AFME 185
Cdd:COG0773 107 IAVAGTHGKTTTTSMLAHILEEAGLD-------PTFLIG-GILNNF---------GTNARLGDGdyfvaeADESdgSFLH 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 186 vsshsidqkrisgLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYSL 265
Cdd:COG0773 170 -------------YSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGRPVITYGF 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 266 RTLADFKGKILESHFEGTEMLVNGR-EVMTRFV----GRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQTIQ 340
Cdd:COG0773 237 SEDADYRAENIRIDGGGSTFDVLRRgEELGEVElnlpGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKG 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 341 SPLGYTAIVDYAHTPDALTNVLSGIHEVLdGNGRVITVVgcggnrdkgkRP-------IMAKE---AAKLSDQLILTSDN 410
Cdd:COG0773 317 EVGGVTVIDDYAHHPTEIAATLAAAREKY-PDRRLVAVF----------QPhrysrtrDFLDEfaeALSLADEVILLDIY 385
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 495421465 411 PRFEEPDEII--KDMVAGLNAADmERTLCITDRAQAIKTATMLARKGDVILVAGKG 464
Cdd:COG0773 386 AAREKPIPGVssEDLAEAIRKRG-KDVVYVPDLDELVEALAEIARPGDVVLTMGAG 440
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
11-358 |
1.20e-26 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 114.03 E-value: 1.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 11 EVLEVVGNADVEISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCeeipvlpdENMQVSESKPVfIRVK 90
Cdd:PRK11929 514 GSNSLQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVV--------ERQVADVDLPQ-IVVD 584
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 91 DSADALGKSLSAWYENPSdnLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLLSTVCNYidgeaiptDHTTPDPVTLHNL 170
Cdd:PRK11929 585 DTRAALGRLATAWRARFS--LPVVAITGSNGKTTTKEMIAAILAAWQGEDRVLATEGNF--------NNEIGVPLTLLRL 654
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 171 MARMvdagcEYAFMEVS-SHSIDQKRISGLSF-NGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKS 248
Cdd:PRK11929 655 RAQH-----RAAVFELGmNHPGEIAYLAAIAApTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPY 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 249 GLVMLQNTAAKK-LTYSLRTLAD-FKGKILESHFEG------TEMLVNGR--EVMTRFVGRFNAYNLLAVYGAAVSLGKD 318
Cdd:PRK11929 730 TAIWAKLAGARRvLRFGLQPGADvYAEKIAKDISVGeaggtrCQVVTPAGsaEVYLPLIGEHNLRNALAAIACALAAGAS 809
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 495421465 319 PEEVLVVLSDLHSVSGRFQTIQSPLGYTAIVD-YAHTPDAL 358
Cdd:PRK11929 810 LKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDtYNANPDSM 850
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
332-420 |
2.97e-22 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 90.48 E-value: 2.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 332 VSGRFQTIQSPLGYTAIVDYAHTPDALTNVLSGIHEVLdgNGRVITVVGCGGNRDKGKRPIMAKEAAKLSDQLILTSDNP 411
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLF--PGRLILVFGGMGDRDAEFHALLGRLAAALADVVILTGDYP 78
|
....*....
gi 495421465 412 RFEEPDEII 420
Cdd:pfam02875 79 RAEDPGAII 87
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
59-464 |
2.31e-19 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 90.44 E-value: 2.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 59 KGAAAIVCEEIpvLPDENMQVSESKPVFIRVKDSADALGKSLSAWYEnpsdnlilVGVTGTNGKTTIATLLYEMFRKMGh 138
Cdd:TIGR01082 57 DDADVVVVSAA--IKDDNPEIVEAKERGIPVIRRAEMLAELMRFRHS--------IAVAGTHGKTTTTAMIAVILKEAG- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 139 kvgLLSTVcnyIDGEAIPTDHTTpdpvtlhnlmARMvdAGCEYAFMEVsshsiDQKRISGLSF--NGGIFTNLTRDHLD- 215
Cdd:TIGR01082 126 ---LDPTV---VVGGLVKEAGTN----------ARL--GSGEYLVAEA-----DESDASFLHLqpNVAIVTNIEPDHLDt 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 216 YHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYSL-RTLADFKGKILESHFEGTE--MLVNGREV 292
Cdd:TIGR01082 183 YGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQVITYGGsGEDADYRAENIQQSGAEGKfsVRGKGKLY 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 293 MTRFV---GRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQTIQSPLGYTAIVDYAHTPDALTNVLSGIHEVL 369
Cdd:TIGR01082 263 LEFTLnlpGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGGVLLIDDYAHHPTEIKATLKAARQGY 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 370 dGNGRVITVVgcGGNRDKGKRPIMA--KEAAKLSDQLILTSDNPRFEEP--DEIIKDMVAGLNAADMERTLCITDRAQAI 445
Cdd:TIGR01082 343 -PDKRIVVVF--QPHRYSRTRDLFDdfAKVLSDADELILLDIYAAGEEPinGIDGKSLARKITQLGKIEPYFVPDLAELV 419
|
410
....*....|....*....
gi 495421465 446 KTATMLARKGDVILVAGKG 464
Cdd:TIGR01082 420 EFLAAVLQSGDLILTMGAG 438
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
114-459 |
2.81e-19 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 90.03 E-value: 2.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 114 VGVTGTNGKTTIATLLYEMFRKMGHKVgllsTVCNYIdgeAIPtdhttpdpvtlhnLMARMVDAGCEYAFM-EVSSHSID 192
Cdd:PRK14106 111 VAITGTNGKTTTTTLLGEIFKNAGRKT----LVAGNI---GYP-------------LIDAVEEYGEDDIIVaEVSSFQLE 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 193 QkrISGLSFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYSLRTLAD-- 270
Cdd:PRK14106 171 T--IKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVIFFSRKSLLEeg 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 271 -F--KGKILESHFEGTEMLVNGREVMTRfvGRFNAYNLLAVYGAAVSLGKDPEEVLVVLSDLHSVSGRFQTIQSPLGYTA 347
Cdd:PRK14106 249 vFvkNGKIVISLGGKEEEVIDIDEIFIP--GEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKF 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 348 IVDYAHT-PDALTNVLSGIHEvldgngrviTVVGCGGNRDKGKR-PIMAKEAAKLSDQLILTSdnprfEEPDEIIKdmva 425
Cdd:PRK14106 327 INDSKGTnPDAAIKALEAYET---------PIVLIAGGYDKGSDfDEFAKAFKEKVKKLILLG-----ETAQEIAE---- 388
|
330 340 350
....*....|....*....|....*....|....
gi 495421465 426 GLNAADMERTLCITDRAQAIKTATMLARKGDVIL 459
Cdd:PRK14106 389 AARKYGFDNILFAETLEEAVKKAYEIAKPGDVVL 422
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
14-340 |
4.08e-17 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 83.54 E-value: 4.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 14 EVVGnADVEISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAI-VCEEIPV-LPdenmQVSeskpvfirVKD 91
Cdd:PRK10773 16 ELQG-ADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALlVSRPLDIdLP----QLV--------VKD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 92 SADALGKsLSAWYENPSDNLIlVGVTGTNGKTTIATLLYEMFRKMGHkvgLLSTVCNYIDGEAIptdhttpdPVTLHNLM 171
Cdd:PRK10773 83 TRLAFGQ-LAAWVRQQVPARV-VALTGSSGKTSVKEMTAAILRQCGN---TLYTAGNLNNDIGV--------PLTLLRLT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 172 ARMvdagcEYAFMEVSSHSIDQkrisgLSFNggifTNLTRD-----------HLDYHKTVENYLKAKKKFFDDLPASAFA 240
Cdd:PRK10773 150 PEH-----DYAVIELGANHQGE-----IAYT----VSLTRPeaalvnnlaaaHLEGFGSLAGVAKAKGEIFSGLPENGIA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 241 LTNADDKSGLVMLQNTAAKKL-TYSLRTL--ADFKGKILESHFEGTEMLVN----GREVMTRFVGRFNAYNLLAVYGAAV 313
Cdd:PRK10773 216 IMNADSNDWLNWQSVIGSKTVwRFSPNAAnsVDFTATNIHVTSHGTEFTLHtptgSVDVLLPLPGRHNIANALAAAALAM 295
|
330 340
....*....|....*....|....*..
gi 495421465 314 SLGKDPEEVLVVLSDLHSVSGRFQTIQ 340
Cdd:PRK10773 296 SVGATLDAVKAGLANLKAVPGRLFPIQ 322
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
113-337 |
1.26e-15 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 79.82 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 113 LVGVTGTNGKTTIATLLYEMFRKMGHKVGLLSTVCNYIDGEAIPTDHTTpDPVTLHN-LMARMVDAgceyAFMEVSSHSI 191
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGVYIDGRLIDKGDCT-GPKSARRvLMNPDVEA----AVLETARGGI 556
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 192 DQkriSGLSFNG---GIFTNLTRDHL--DYHKTVENYLKAKKKFFDDLPASAFALTNADDKSGLVMLQNTAAKKLTYSLR 266
Cdd:PRK14016 557 LR---EGLAYDRcdvGVVTNIGEDHLglGGINTLEDLAKVKRVVVEAVKPDGYAVLNADDPMVAAMAERCKGKVIFFSMD 633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 267 ----TLADF--KGK-----------ILESHFEgtEMLVNGREVMTRFVGR--FNAYNLLAVYGAAVSLGKDPEEVLVVL- 326
Cdd:PRK14016 634 pdnpVIAEHraQGGravyvegdyivLAEGGWE--IRIISLADIPLTLGGKagFNIENALAAIAAAWALGIDIELIRAGLr 711
|
250
....*....|....
gi 495421465 327 ---SDLHSVSGRFQ 337
Cdd:PRK14016 712 tfvSDAAQAPGRFN 725
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
22-104 |
2.22e-15 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 71.11 E-value: 2.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 22 EISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEeipvlpDENMQVSESKP-------VFIRVKDSAD 94
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGH------DAANNISPDNPeleaakvPGIPVIDRRE 74
|
90
....*....|
gi 495421465 95 ALGKSLSAWY 104
Cdd:pfam01225 75 ALAELAAAFY 84
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
14-351 |
4.39e-15 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 78.08 E-value: 4.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 14 EVVGNADVEISGIQSDSRKVE--KGFLFVAVRGTAVDGHAYIQSAIEKGA--AAIVCEEIP--VLPDENmqvseskpvFI 87
Cdd:PRK11930 15 EGLGDKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVrnFVVSEEKHPeeSYPDAN---------FL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 88 RVKDSADALGKsLSAWYENPSDnLILVGVTGTNGKTTIATLLYEmfrkmghkvgLLStvcnyidgeaipTDHTT---PD- 163
Cdd:PRK11930 86 KVKDPLKALQE-LAAYHRSQFD-IPVIGITGSNGKTIVKEWLYQ----------LLS------------PDYNIvrsPRs 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 164 -------PVTLHNLMARMVDAGCEYAFMEVSSHSIDQKRISGlsfNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPA 236
Cdd:PRK11930 142 ynsqigvPLSVWQLNEEHELGIFEAGISQPGEMEALQKIIKP---TIGILTNIGGAHQENFRSIKQKIMEKLKLFKDCDV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 237 SAFALTNaDDKSGLVMLQNTAAKKLTYSLRTL-ADFKGKILESHFEGTEMLVNGREVMTRFVGRFNAY----NLLAVYGA 311
Cdd:PRK11930 219 IIYNGDN-ELISSCITKSNLTLKLISWSRKDPeAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDasieNLIHCIAV 297
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 495421465 312 AVSLGKDPEEVLVVLSDLHSVSGRFQTIQSPLGYTAIVDY 351
Cdd:PRK11930 298 LLYLGYSADQIQERMARLEPVAMRLEVKEGINNCTLINDS 337
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
88-462 |
1.99e-13 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 72.06 E-value: 1.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 88 RVKDSADALGkslsawyeNPSDNLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLlstvcnY-------------IDGEA 154
Cdd:COG0285 25 RIRALLERLG--------NPQRKLPVIHVAGTNGKGSTAAMLESILRAAGYRVGL------YtsphlvrfnerirINGEP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 155 IP---------------TDHTTPDP-----VTlhnLMA--RMVDAGCEYAFMEVsshsidqkrisGLsfnGG-------- 204
Cdd:COG0285 91 ISdeelvealeevepavEEVDAGPPtffevTT---AAAflYFAEAPVDVAVLEV-----------GL---GGrldatnvi 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 205 -----IFTNLTRDHldyhktvENYLKakkkffDDLPASAF-----------ALTNADDKSGLVMLQNTAAKK-------- 260
Cdd:COG0285 154 dplvsVITSIGLDH-------TDFLG------DTLEEIARekagiikpgvpVVTGDQQPEALEVIEERAAELgaplyrag 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 261 --LTYSLRTLADFKGKILESHFEgtemlvngrEVMTRFVGRFNAYNLLAVYGAAVSLGK-----DPEEVLVVLSDLHSvS 333
Cdd:COG0285 221 rdFSVEEREGAVFSYQGPGGEYE---------DLPLPLLGAHQAENAALALAALEALRElglpiSEEAIREGLANARW-P 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 334 GRFQTIQSplGYTAIVDYAHTPDALTNVLSGIHEvLDGNGRVITVVGCGGNRDKGKrpiMAKEAAKLSDQLILTS-DNPR 412
Cdd:COG0285 291 GRLEVLSR--GPLVILDGAHNPAGARALAETLKE-LFPFRKLHLVFGMLADKDIEG---MLAALAPLADEVIVTTpPSPR 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 495421465 413 FEEPDEiIKDMVAGLNAadmeRTLCITDRAQAIKTATMLARKGDVILVAG 462
Cdd:COG0285 365 ALDAEE-LAEAARELGL----RVEVAPDVEEALEAALELADPDDLILVTG 409
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
14-380 |
1.84e-08 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 56.71 E-value: 1.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 14 EVVGNADVEISGIQSDSRKVEKGFLFVAVRGTAVDGHAYIQSAIEKGAAAIVCEEipvlpDENMQVSESKPVFIrVKDSA 93
Cdd:PRK14093 19 TRSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVER-----AQRDKFAADAPLLV-VDDVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 94 DAL---GKSLSAWYENPsdnliLVGVTGTNGKTTIATLLYEMFRKMG--HkvgllSTVCNYIDGEAIPTDhttpdpvtlh 168
Cdd:PRK14093 93 AALrdlGRAARARLEAK-----VIAVTGSVGKTSTKEALRGVLGAQGetH-----ASVASFNNHWGVPLS---------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 169 nlMARMvDAGCEYAFMEVS-SHSIDQKRISGL-SFNGGIFTNLTRDHLDYHKTVENYLKAKKKFFDDLPASAFALTNADD 246
Cdd:PRK14093 153 --LARC-PADARFAVFEIGmNHAGEIEPLVKMvRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 247 kSGLVMLQNTAAKK-----LTYSLRTLADFKGKILESHFEGTEML--VNGREVMTRF--VGRFNAYNLLAVYGAAVSLGK 317
Cdd:PRK14093 230 -PQFDRLAASARAAgiariVSFGADEKADARLLDVALHADCSAVHadILGHDVTYKLgmPGRHIAMNSLAVLAAAELAGA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 318 DPEEVLVVLSDLHSVSGR--FQTIQSPLGYTAIVD--YAHTPD---ALTNVLSGIHevLDGNGRVITVVG 380
Cdd:PRK14093 309 DLALAALALSQVQPAAGRgvRHTLEVGGGEATLIDesYNANPAsmaAALGVLGRAP--VGPQGRRIAVLG 376
|
|
| folC |
TIGR01499 |
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of ... |
88-213 |
3.52e-06 |
|
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273659 [Multi-domain] Cd Length: 397 Bit Score: 49.20 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421465 88 RVKDSADALGkslsawyeNPSDNLILVGVTGTNGKTTIATLLYEMFRKMGHKVGLLST---------VCnyIDGEAIP-- 156
Cdd:TIGR01499 3 RMKKLLEALG--------NPQDLYPVIHVAGTNGKGSTCAFLESILRAAGYKVGLFTSphlvsfnerIR--INGEPISde 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495421465 157 -----TDHTTPDPVTLHN---------LMARM--VDAGCEYAFMEV------SSHSIDQKRISGlsfnggiFTNLTRDH 213
Cdd:TIGR01499 73 elaqaFEQVRPILESLSQqptyfelltLLAFLyfAQAQVDVAVLEVglggrlDATNVIEPLVSV-------ITSIGLDH 144
|
|
| |
