|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
17-395 |
2.59e-105 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 316.47 E-value: 2.59e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 17 FVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLL 96
Cdd:cd17394 1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 97 FIPSEQLMSFNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNGD---- 172
Cdd:cd17394 81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPStata 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 173 -----------------ANIALPYTVMGVIVLSVALIFFRIRLPEINHDdcEDTTAEAKAGLKGLWKHRCFTWGVMALFC 235
Cdd:cd17394 161 laamsaaelqayktaelASVQLPYLGIALVLLLLAVLILLSKLPEIEAA--EAEALGSKGTLLRLLKNPHLRLGVLAIFF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 236 YEIAEISINSFFINYVTDD-GWMDAHDAAIVLSFgGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGT 314
Cdd:cd17394 239 YVGAEVAIWSFLINYLMEYiAGLTETSAATFVSY-YWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGGM 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 315 LSKGALFACYIFEAIMFPTIFAISLRGLGDYTKRASSFLMMSPIGGAVGPLLMGYVA-DISTMSFSFVVPLFGYAVVLIY 393
Cdd:cd17394 318 VALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIAFLVPLLCFAYILFY 397
|
..
gi 495421578 394 SY 395
Cdd:cd17394 398 GL 399
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-401 |
1.08e-84 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 263.25 E-value: 1.08e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 10 KKEYLVPFVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLIL 89
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 90 YGIGSLLFIpseQLMSFNFFLFSLFVIGCGLTFLETAANPYVTELGdRETAASRLNLAQSFNGLGCICAPVIGGMLLFSG 169
Cdd:COG0738 83 MALGLLLFA---LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 170 nGDANIALPYTVMGVIVLSVALIFFRIRLPEINHDdcEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFIN 249
Cdd:COG0738 159 -LSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEE--EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 250 YVTDDGWMDAHDAAIVLSFgGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLG-ALFVTLNLGTLSKGALFACYIFEA 328
Cdd:COG0738 236 YLKDVLGLSEATAALGLSL-FWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGlLLALLAPGPWLALIGLALVGLGLS 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495421578 329 IMFPTIFAISLRGLGDYT-KRASSFLMMSPIGGAVGPLLMGYVADISTMSFSFVVPLFGYAVVLIYSYMVMAKK 401
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| fucP |
TIGR00885 |
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ... |
13-393 |
4.93e-83 |
|
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211614 Cd Length: 408 Bit Score: 259.79 E-value: 4.93e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 13 YLVPFVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGI 92
Cdd:TIGR00885 1 YIIPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 93 GSLLFIPSEQLMSFNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSG--- 169
Cdd:TIGR00885 81 GAFLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSNlph 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 170 -------------------NGDANIALPYTVMGVIVLSVALIFFRIRLPEINHDDCEDttAEAKAGLKGLWKHRCFTWGV 230
Cdd:TIGR00885 161 qsqdvldklspeelsaikhSDLASVQTPYMIIGAVVLAVALLIMLTKMPALNHSDAKQ--ISFSASLSRLARIRHYREGV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 231 MALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTL 310
Cdd:TIGR00885 239 IAQFFYVGVQIMCWTFIIQYAVRLIPGMTAGFAANYNIGAMVIFFISRFIGTWLISYLAAHKVLMAYAIIGMALCLGSIF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 311 NLGTLSKGALFACYIFEAIMFPTIFAISLRGLGDYTKRASSFLMMSPIGGAVGPLLMGYVADIS------TMSFSFVVPL 384
Cdd:TIGR00885 319 AGGHVGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDMKeiaaapAVNTSFILPL 398
|
....*....
gi 495421578 385 FGYAVVLIY 393
Cdd:TIGR00885 399 LCFAVIFIY 407
|
|
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
11-394 |
1.49e-68 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 223.23 E-value: 1.49e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 11 KEYLVPFVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILY 90
Cdd:PRK10133 22 RSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 91 GIGSLLFIPSEQLMSFNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGN 170
Cdd:PRK10133 102 ALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 171 GDA----------------------NIALPYTVMGVIVLSVALIFFRIRLPEINHDDCEDTTAEA-KAGLKGLWKHRCFT 227
Cdd:PRK10133 182 PHQsqdvldkmtpeqlsaykhslvlSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSfSASLSRLARIRHWR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 228 WGVMALFCYEIAEISINSFFINYVTDD-GWMDAHDAAIVLSfGGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGAL 306
Cdd:PRK10133 262 WAVLAQFCYVGAQTACWSYLIRYAVEEiPGMTAGFAANYLT-GTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCL 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 307 FVTLNLGTLSKGALFACYIFEAIMFPTIFAISLRGLGDYTKRASSFLMMSPIGGAVGPLLMGYVAD-ISTMSFSFVVPLF 385
Cdd:PRK10133 341 ISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDaAGNIPTAELIPAL 420
|
....*....
gi 495421578 386 GYAVVLIYS 394
Cdd:PRK10133 421 CFAVIFIFA 429
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
97-393 |
5.04e-46 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 160.45 E-value: 5.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 97 FIPSEQLMSFNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNGD---- 172
Cdd:TIGR01272 1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDlsmq 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 173 --------ANIALPYTVMGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISIN 244
Cdd:TIGR01272 81 vatanaeaAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSGDTTQKTSAFQFTHLVLGALGIFVYVGAEVSAG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 245 SFFINYVTDD--GWMDAHDAAIVLSFGgLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLSKGALFA 322
Cdd:TIGR01272 161 SFLVNFLSDPhaLGLPEDQAAHFTAYT-WGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTHGYVAMWFVLA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495421578 323 CYIFEAIMFPTIFAISLRGLGDYTKRASSFLMMSPIGGAVGPLLMGYVADISTMSFSFVVPLFGYAVVLIY 393
Cdd:TIGR01272 240 LGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAFALPVPCYLYILFY 310
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
22-392 |
2.69e-33 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 127.82 E-value: 2.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 22 SLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIPSE 101
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 102 QLMsfnFFLFSLFVIGCGLTFLETAANPYVTELGDrETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNgdaNIALPYTV 181
Cdd:cd17333 83 SIY---LFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 182 MGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFT-WGVMALFCYEIAEISINSFFINYVTDDGWMDAH 260
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIiLGALALFLYVGAETAFSSWVPSYLVEKKHVSDG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 261 DAAIVLSfGGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLSKGALFACY-IFEAIMFPTIFAISL 339
Cdd:cd17333 236 LAGYLLS-GFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLgLFMAALFPTILSLGI 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 495421578 340 RGLGDYTKRASSFLMMS-PIGGAVGPLLMGYVADISTMSFSFVVPLFGYAVVLI 392
Cdd:cd17333 315 SNLPYAKGKGTSVLLAAgSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFV 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-392 |
9.85e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.02 E-value: 9.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 20 VTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIP 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 100 SEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGML-LFSGNGDANIALP 178
Cdd:cd06174 81 APSF---WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILaSSLGFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 179 YTVMGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGWMD 258
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 259 AHDAAIVLSFGGLGlFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLSKGALFACYI---FEAIMFPTIF 335
Cdd:cd06174 238 VAVAGLLLSLFGLA-GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLgfgLGGLLPLSFA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 495421578 336 AISLRGLGDYTKRASSFLMMS-PIGGAVGPLLMGYVADISTMSFSFVVPLFGYAVVLI 392
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFgFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-382 |
3.51e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.46 E-value: 3.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 62 GYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIPSEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAA 141
Cdd:cd17325 43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY---WQLLLARFLQGLASAAVWPAAMALIADIAPPEERG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 142 SRLNLAQSFNGLGCICAPVIGGMLLFSGngdaNIALPYTVMG-VIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGL 220
Cdd:cd17325 120 RAMGIFSSAIGLGFLIGPLLGGLLADAL----GYRAPFLVCAaLALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 221 WKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGlFMIGRIIGSWIMSYIRAEKVLFICAIF 300
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA-SALSQPPAGKLSDRIGRKPLILIGLLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 301 TVLGALFVTLNLGTLSKGALFACY-IFEAIMFPTIFAISLR--GLGDYTKRASSFLMMSPIGGAVGPLLMGYVADISTMS 377
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADivPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
|
....*
gi 495421578 378 FSFVV 382
Cdd:cd17325 355 TPFLA 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-356 |
6.19e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 72.31 E-value: 6.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 14 LVPFVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIG 93
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 94 SLLFIPSEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLfsgnGDA 173
Cdd:COG2814 89 SLLCALAPSL---WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA----DLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 174 NIALPYTVMGVIVLsVALIFFRIRLPEinhdDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTD 253
Cdd:COG2814 162 GWRWVFLVNAVLAL-LALLLLLRLLPE----SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 254 DGWMDAHDAAIVLSFGGLGlFMIGRIIGSWIMSYIRAEKVLFICAIFTVLG-ALFVTLNLGTLSKGALFACYIFEAIMFP 332
Cdd:COG2814 237 VLGLSASAAGLLLALFGLG-GVLGALLAGRLADRFGRRRLLLIGLLLLALGlLLLALAGSLWLLLLALFLLGFGFGLLFP 315
|
330 340
....*....|....*....|....*
gi 495421578 333 TIFAISLRGLGDYTK-RASSFLMMS 356
Cdd:COG2814 316 LLQALVAELAPPEARgRASGLYNSA 340
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-401 |
7.44e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 66.44 E-value: 7.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 17 FVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLL 96
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 97 FIPSEQLMsfnFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLfsgnGDANIA 176
Cdd:COG2223 87 LALAVSYW---LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI----AAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 177 LPYTVMGVIVLSVALIFFRI--RLPEinhdDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDD 254
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFlrDPPA----GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 255 GWMDAHDAAIVLSFGGLgLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLSK--GALFACYIFEAIMFP 332
Cdd:COG2223 236 FGLSAATAGLLAALFAL-LGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLflVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495421578 333 TIFA-ISLRGLGDYTKRASSFL-MMSPIGGAVGPLLMGYVADIS-TMSFSFVVPLFGYAVVLIYSYMVMAKK 401
Cdd:COG2223 315 AVFAlVPDIFPTKNAGAVYGLVgAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-403 |
5.19e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.74 E-value: 5.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 17 FVLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLL 96
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 97 --FIPSEQLMsfnffLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLfsgngdAN 174
Cdd:COG2271 92 fgFATSFWQL-----LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL------AA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 175 IALPYTVMGVIVLSVALIFFRIRLpeinhddcedttaeakaglkglwkhrcftwGVMALFCYEIAEISINSFFINYVTDD 254
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWL------------------------------LALAYFLVYFALYGFLTWLPTYLVEV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 255 GWMDAHDAAIVLSFGGLGlFMIGRIIGSWIMSYI--RAEKVLFICAIFTVLGALFVTLNLGTLSKGALFACYIFEAIMFP 332
Cdd:COG2271 211 RGLSLAQAGLLLSLPFLA-GIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495421578 333 TIFAISLRGLGDYTKRASSF---LMMSPIGGAVGPLLMGYVADISTMSFSFVVpLFGYAVVLIYSYMVMAKKLR 403
Cdd:COG2271 290 GLLWALAAELFPKKARGTASglvNTFGFLGGALGPLLVGYLLDATGYQAAFLL-LAALALLAALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
36-364 |
8.00e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 8.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 36 VLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIPSEQLmsfNFFLFSLFV 115
Cdd:pfam07690 18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL---WLLLVLRVL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 116 IGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGngdaNIALPYTVMGVI-VLSVALIFF 194
Cdd:pfam07690 95 QGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----GWRAAFLILAILsLLAAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 195 RIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGWmDAHDAAIVLSFGGLgLF 274
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL-SALLAGLLLGLGGL-LG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 275 MIGRIIGSWIMSYIRAEKVLFICAIFTVLG----ALFVTLNLGTLSKGALFACYIFEAIMFPTIFAISLRGLG-DYTKRA 349
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRRRRLLLALLLLILAalglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTA 328
|
330
....*....|....*.
gi 495421578 350 SSFL-MMSPIGGAVGP 364
Cdd:pfam07690 329 SGLYnTAGSLGGALGP 344
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
18-394 |
5.06e-09 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 57.65 E-value: 5.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 18 VLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLF 97
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 98 IPSEQLMSFNFFLFslfVIGCGLTFLETAANPYVTELgDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGngdANIAL 177
Cdd:cd17393 82 GLAPSVPALALALF---LFGAANGALDVAMNAQGVAV-ERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAG---VSPGV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 178 PYTVMGVIVLSVALIFFRiRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYeIAEISINSFFINYVTDDGWM 257
Cdd:cd17393 155 HLLAAAVLLLLAALVAIR-ALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAA-LAEGAAADWSALYLRDVLGA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 258 DAHDAAIVlsFGGLGLFM-IGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLSKGALFACYIFE-AIMFPTIF 335
Cdd:cd17393 233 SAALAALG--YAVFSLAMtVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGlSVVVPLAF 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 336 AISLRGLGDYTKRASSFL-MMSPIGGAVGPLLMGYVADISTMSFSFVVPLFGYAVVLIYS 394
Cdd:cd17393 311 SAAGALPGLAAGIAVARVaTLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLA 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
54-393 |
2.27e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.26 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 54 LIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIPSEQLMsfnFFLFSLFVIGCGLTFLETAANPYVTE 133
Cdd:cd17477 35 LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW---VWFLLRFVMGIGLAGLFVVSESWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 134 LGDRETAASRLNLAQSFNGLGCICAPVIGGMllfsgnGDANIALPYTVMGVIVLSVALIFFRIRLPEInhddceDTTAEA 213
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLAL------VGTAGALPFLIAAVLLLLALVPLLLTRRAAP------EIEEAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 214 KAGLKGLWkhRCFTWGVMALFCYEIAEISINSFFINYVTDDGwMDAHDAAIVLSFGGLGLFMIGRIIGSWIMSYIRaEKV 293
Cdd:cd17477 180 SISLRRLL--RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 294 LFICAIFTVLGALFVTLnLGTLSKGALFACYIFEAIMFPtIFAISLRGLGDYTKRA------SSFLMMSPIGGAVGPLLM 367
Cdd:cd17477 256 LLGCALLGALAALLLPL-VPGLPLALLVLLFLWGGAAGP-LYTLALALAGDRLPGDelvaanAALLLLYGLGSVIGPLLA 333
|
330 340
....*....|....*....|....*.
gi 495421578 368 GYVADISTMSFSFVVPLFGYAVVLIY 393
Cdd:cd17477 334 GALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
53-396 |
2.46e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 53 ALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGI--GSLLFIPSEQLMSFNFFLFSLFVIGCGLTFLETAANPY 130
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALlaAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 131 VTELGDRE--TAASRLNlaQSFNGLGCICAPVIGGMLLFSGNGDANIALpytVMGVIVLSVALIFF-RIRLPEINHDDCE 207
Cdd:cd06173 117 LPELVPKEqlVRANALN--SLATQLARIIGPALGGLLVALLGPGGAFAI---NALSFLLSALLLLFiRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 208 DTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGLfMIGRIIGSWIMSY 287
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGA-LLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 288 IRAEKVLFICA-IFTVLGALFVTLNLGTLSKGALFACYIFEAIMFPTIFAI-------SLRGlgdytkRASSFLMMSPIG 359
Cdd:cd06173 271 RRRGRLLLIGAlLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlqlrvpdELRG------RVFSVYNALNSG 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 495421578 360 G-AVGPLLMGYVADISTMSFSFVVPLFGYAVVLIYSYM 396
Cdd:cd06173 345 AmPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
66-392 |
3.21e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.80 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 66 MAIPAGLFINKYGYRQGVVFGLILYGIGSLL--FIPSEQLMsfnffLFSLFVIGCGLTFLETAANPYVTELGDRETAAsR 143
Cdd:COG2807 69 FAPLAPRLARRFGLERTLLLALLLLAAGLLLrsLAPSVALL-----LAGTALIGAGIAVGNVLLPGLIKRWFPDRVGL-M 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 144 LNLAQSFNGLGCICAPVIGGMLLfsgnGDANIALPYTVMGVIVLsVALIFFRIRLPEINHddcEDTTAEAKAGLKGLWKH 223
Cdd:COG2807 143 TGLYTAAMGLGAALAAGLTVPLA----AALGWRGALAVWALLAL-LALLLWLPLLRRRPA---AAAAAPAAASLRSLWRS 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 224 RcFTWGVMALF-CYEIAEISINSFFINYVTDDGWmDAHDAAIVLSFGGLGLfMIGRIIGSWIMSYIRAEK-VLFICAIFT 301
Cdd:COG2807 215 P-LAWLLTLFFgLQSLLYYAVVAWLPPILRDAGL-SAATAGLLLSLFQLAG-IPGSLLVPLLADRLGDRRpLLLLLGLLG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 302 VLGALFVTLNLGTLSKGALFACYIFEAIMFPTIFAISLRGLGDYTKRASSFLMMSPIG---GAVGPLLMGYVADISTmsf 378
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGyllAALGPLLVGALHDATG--- 368
|
330
....*....|....
gi 495421578 379 SFVVPLFGYAVVLI 392
Cdd:COG2807 369 SWTAALLLLAALAV 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-197 |
4.00e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.42 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 2 EKVKKSLVKKEYLVPFVLVTSLFFLWGFAHAILDVlnkHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQ 81
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL---YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 82 GVVFGLILYGIGSLLFIPSEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVI 161
Cdd:cd17325 267 LILIGLLLSAVALLLLPLATSF---WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
170 180 190
....*....|....*....|....*....|....*.
gi 495421578 162 GGMLLFSGngdaNIALPYTVMGVIVLSVALIFFRIR 197
Cdd:cd17325 344 GGFLYDAF----GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
83-374 |
6.38e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 83 VVFGLILYGIGSLLF---IPSEQLMSFNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLN-LAQSFNGLGCICA 158
Cdd:COG2211 84 ILIGAIPLALSFVLLftaPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 159 PVIGGMLL--FSGNGDANIALPYTVMGVIVLsVALIFFRIRLPEinHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCY 236
Cdd:COG2211 164 SVLPPPLVaaFGGDAALGYRLTALIFAVLGL-LAFLLTFFGTKE--RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLF 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 237 EIAEISINSFFINYVTDDgWMDAHDAAIVLSFGGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLnLGTLS 316
Cdd:COG2211 241 FLALALVAALLLYYFKYV-LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-LGPGN 318
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495421578 317 KGALFAC----YIFEAIMFPTIFAIsLRGLGDYTKR----------ASSFLMMSPIGGAVGPLLMGYVADIS 374
Cdd:COG2211 319 LWLLLVLaalaGIGLGAILVLPWAM-LADVVDYDEWktgrrreglyFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
53-391 |
2.56e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.11 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 53 ALIQATMYTGYFTMAIP---AGLFINKYGYRQGVVFGLILYGIGSLLFIPSEQLMSFNFFLFSLFVIGCGLT----FLET 125
Cdd:cd17355 38 AVISLAFTVGLLAFGLAqpfVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLaavaFATV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 126 AANPYVTELGdreTAASRLNLAQSFNGLgcICAPVIGGMLLFSGNGDANIALPyTVMGVIVLSVALIFFRIRLPEINHDD 205
Cdd:cd17355 118 AAWWFERRRG---LALGILTAGGGLGSL--VFLPLGAALIEAFGWRTALLVLA-LLALLVLVPVLLLLRRRPADLALRAY 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 206 CEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGwMDAHDAAIVLSFGGLGLfMIGRIIGSWIM 285
Cdd:cd17355 192 DDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG-ISPAAAAVALALIGLFN-IVGRLLSGWLG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 286 SYIRAEKVLFICAIFTVLGALFVtLNLGTLSKGALFACYIFEAIMFPTI-----FAISLRGLGDYTKRASSFLMMSPIGG 360
Cdd:cd17355 270 DRYSPRRLLAASYALRALGLALL-LLLPFPPLALLLFAALFGLGWGATVpltaaLAARYFGARSYGTLFGLVFAPHQLGS 348
|
330 340 350
....*....|....*....|....*....|....
gi 495421578 361 AVGPLLMGYVADIS---TMSFSFVVPLFGYAVVL 391
Cdd:cd17355 349 ALGPWLGGLLYDRTgsyTAAWALAVALGLIAALL 382
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
66-382 |
5.43e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 66 MAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIPSEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLN 145
Cdd:cd17474 50 LMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF---ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 146 LAQSFNGLGCICAPVIGGMLlfsgngdANIALPYTVMGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRC 225
Cdd:cd17474 127 LYEAALGLGIAVGPLLGGLL-------AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRG 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 226 FTWGVMALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFT--VL 303
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYalSL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 304 GALFVTLNLGTLSkGALFACYIFEAIMFPTIFAISLRGLGDYTKRASSFL--MMSPIGGAVGPLLMGYVADISTMSFSFV 381
Cdd:cd17474 280 LLLGFVPSLALLL-IAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLynFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
.
gi 495421578 382 V 382
Cdd:cd17474 359 V 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
70-393 |
1.27e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 70 AGLFINKYGYRQGVVFGLILYGIGSL--LFIPSEQLMsfnffLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLA 147
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGGVagLFLDSLYAL-----LASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 148 QSFNGLGCICAPVIGGMLlfsgnGDANIALPYTVMGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLkgLWKHrcFT 227
Cdd:cd17473 130 SAAMSLGGVVFLLLGGAL-----AEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAAL--PWKR--VL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 228 WGVMALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGLfMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALF 307
Cdd:cd17473 201 PIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG-AIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 308 VTL--NLGTLSKGALFACYIFeAIMFPTIFAISLRGLGDYTK-RASSFLMMSP-IGGAVGPLLMGYVADI-STMSFSFVV 382
Cdd:cd17473 280 LALasGLWVVLLGAILAGLGF-GLLLPTLNSWAMSLVPPELRgRAMGIVTSAFfLGQFLSPLVLGPLVNLtGGLSGAFLI 358
|
330
....*....|....
gi 495421578 383 P---LFGYAVVLIY 393
Cdd:cd17473 359 LgvlALVLAIVLLL 372
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
83-337 |
1.78e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.36 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 83 VVFGLILYGIGS-LLFIPSEQLMSFNFFLFSLFVIGCGLTFleTAAN-PY---VTELGDRETAASRLN-LAQSFNGLGCI 156
Cdd:cd17332 73 LLWGAIPLALLFvLLFTTPDGSGTGKLIYALITYILLDLLY--TLVNiPYtalIPELTDDPEERTSLTsWRMFFATIGGL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 157 CAPVIGGMLL-FSGNGDANIALPYT--VMGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMAL 233
Cdd:cd17332 151 LVTVLPPPLVaYFGGGNASRGYFLTalIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAY 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 234 FCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGLFMIgrIIGSWIMSYIRAEKVLFI---CAIFTVLGALFVTL 310
Cdd:cd17332 231 LLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLAL--LPWPPLKKRFGKKKAFFIgllLAILGLLLLFFLPP 308
|
250 260
....*....|....*....|....*..
gi 495421578 311 NLGTLSKGALFACYIFEAIMFPTIFAI 337
Cdd:cd17332 309 GNLVLILVLAVLAGIGYGGANLLPWAM 335
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-372 |
2.91e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 18 VLVTSLFFLWGFAHAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLF 97
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 98 IPSEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNGDANIAl 177
Cdd:cd17329 83 GFAHSP---WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 178 pytvmGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGWM 257
Cdd:cd17329 159 -----AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 258 DAHDAAIVLSFGGLgLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLnlgTLSKGALFACYIF----EAIMFPT 333
Cdd:cd17329 234 GESLLGLLLALNAL-LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF---ANTLAVLILAMIVltlgEMLVFPA 309
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 495421578 334 IFAISLRgLGDYTKRASSF---LMMSPIGGAVGPLLMGYVAD 372
Cdd:cd17329 310 VQTLVAA-LAPPDKRGSYMgfyALAWGLGRAIGPLVGGLLLD 350
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
50-396 |
3.81e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.18 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 50 AHSALIQATMYTGYFTMAI---PAGLFINKYGYRQGVVFGLILYGIGSLL--FIPS-EQLMSFNFflfslfVIGCGLTFL 123
Cdd:cd17320 31 ASASAVQLTLSAYLLGFALgqlLYGPLSDRFGRRPVLLAGLLLFILASLLcaLASSiEQLLIARF------LQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 124 ETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNGDANIalpYTVMGVIVLSVALIFFRirLPEINH 203
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF---VFLALLGLLLLLLVLLF--LPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 204 DDCEDTTAEAKAG-LKGLWKHRCFTWGVM-------ALFCYeiaeISINSFFinYVTDDGwMDAHDAAIVLSFGGLGlFM 275
Cdd:cd17320 180 EEKRKPLLSSLLRaYKRVLKNRRFLGYALalglsfaGLFAY----LAAAPFI--YIEQLG-LSPAQFGLLFALNAIA-LI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 276 IGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLSKG------ALFACYIFEAIMFPTIFAISLRGLGDYTKRA 349
Cdd:cd17320 252 LGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSlwplvaPLFLIFFGFGLIFPNATSLALEPFPHVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 495421578 350 SSFL-MMSPIGGAVGPLLMGYVADISTMSFSFVVPLFGYAVVLIYSYM 396
Cdd:cd17320 332 SALLgFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-392 |
6.52e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 17 FVLVTSLFFLWGFAH---AILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIG 93
Cdd:cd17319 2 WRIIPLLFLAYVINYldrVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 94 SLlfipseqLMSFNFFLFSLFVIGCGLTFLETAANP----YVTEL---GDRETAASRLNLAQSFnglGCICAPVIGGMLL 166
Cdd:cd17319 82 TA-------LTGFATSLTSLYVLRFLLGVAEAGFFPgaikALAEWfpaRERGRATGLFNSGAPL---GAAIGPPLSGWLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 167 FSGNGDANialpYTVMGVIVLsVALIFFRIRLPEInhddcedttaeakaglkglwkhrcftWGVMAL-FCYEIAEISINS 245
Cdd:cd17319 152 LLFGWRWA----FIIEGLLGL-LLAVLWWFYLRQV--------------------------WGLALGyFGINYALYGLLT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 246 FFINYVTDDGWMDAHDAAIVLSFGGLGLFmIGRIIGSWIMSYI---RAEKVLFICAIFTVLGALFVTLNLG-TLSKGALF 321
Cdd:cd17319 201 WLPTYLKQARGFSLKQVGLLAAIPFLAGA-IGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSpVVAVILLS 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495421578 322 ACYIFEAIMFPTIFAISlrglGDYTKRASS------FLMMSPIGGAVGPLLMGYVADISTmsfSFVVPLFGYAVVLI 392
Cdd:cd17319 280 LAGFGIGAASPVFWSLP----ADLLPGEAAatagglINSGGNLGGFVAPLLIGYLVDATG---SYTAAFLFLAAVAL 349
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
71-382 |
1.07e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 71 GLFINKYGYRQGVVFGLILYGIG--SLLFIPSEQLMSFNFFlfslfVIGCGLTFLETAANPYVtelgdRETAASRLNLAQ 148
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGlsLLGFAPNYWLLLLLVA-----LAGIGSAAFHPEGARLA-----SQAAGGRRGLAM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 149 SFNG----LGCICAPVIGGMLLFSGNGdaniaLPYTVMGVIV-LSVALIFFRIRLPEINHDDCEDTTAEAKAGLKGLWKH 223
Cdd:cd17478 122 SIFSvggnLGFALGPLIAAALVALFGG-----LGLLILLIIPgLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 224 RCFTWGVMalFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGlfMIGRIIGSWIMSYIRAEKVLFICAIFTVL 303
Cdd:cd17478 197 LLLLLIIV--FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAG--AIGTLIGGPLSDRFGRRRVIIASLLLAAP 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 304 GALFVTLNLGTLSKGALFACYIFEAIMFPTIFAISLRGLGDYTKRASSFLM-MSPIGGAVGPLLMGYVADISTMSFSFVV 382
Cdd:cd17478 273 FLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMgLSFGLGGIGAPVLGALADAFGLESVLLI 352
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
70-394 |
1.09e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 70 AGLFINKYGYRQGVVFGLILYGIGSLLFIPSEQLmsfNFFLFSLFVIGCGLTFLETAANPYVTELGDRETAASRLNLAQS 149
Cdd:cd17489 51 AGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV---ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 150 FNGLGCICAPVIgGMLLFSGNGdanIALPYTVMGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAGL--KGLWKHrcft 227
Cdd:cd17489 128 ATTLAMALGPAL-GLFLYQHLG---FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLveKKVLPP---- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 228 wgVMALFCYEIAEISINSFFINYVTDDGWmdaHDAAIVLSFGGLGLFMIGRIIGSWIMSYIRAeKVLFICAIFTVLG-AL 306
Cdd:cd17489 200 --ALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLLSRPFSGKLSDRKGPK-TVIIPGLLLLALGlLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 307 FVTLNLGTLSKGALFACYIFEAIMFPTIFAISLRgLGDYTKRA---SSFLMMSPIGGAVGPLLMGYVADI----STMSFS 379
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVD-LVPPHRRGaanGTFFIFFDLGIGLGGLLLGLVAELfgyrAMFLLA 352
|
330
....*....|....*
gi 495421578 380 FVVPLFGYAVVLIYS 394
Cdd:cd17489 353 AVVVLLALVLYIFLL 367
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
117-397 |
1.65e-03 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 40.20 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 117 GCGLTFLETAANPYVTELGdRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGngdanialpYTVMGVIVLSVALIFFRI 196
Cdd:cd17395 96 GLAMGCLDTGANMQIVRMW-QKDSAPFLQVLHFSFGFGAFLAPLIADPFLSYA---------YWIMALINLPVPMAVLML 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 197 RLPEINHDDCEDTTAEAKAGLKGLWKHRCFTwGVMALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGgLGLFMI 276
Cdd:cd17395 166 LSKERLLTCCSQRRRKNLRRAPYSFFAIHIT-GALFLFMYVGLEGAYGAFVYSYAVEKPGVGHKVAAYLPSLF-WGTFTL 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 277 GRIIGSWIMSYIRAEKVLFICaiftVLGALFVTLNLGTLSKGALF-----ACY-IFEAIMFPTIFAISlRGLGDYTKRAS 350
Cdd:cd17395 244 GRLLSIPISSRMKPATMVVLN----VVGVVVTSLVLLLFSKSVVFlwigtASLgLFLASTFPSMLSYT-EDSLQYTGCST 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 495421578 351 SFLMmspIGGAVG----PLLMGYVA-DISTMSFSFVVPLFGYAVVLIYSYMV 397
Cdd:cd17395 319 TVLV---TGAGLGemvlPMLVGSIQpFQAQGSYSFLVCGVLFGCLAFTFYIL 367
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
50-373 |
1.82e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 50 AHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLL--FIPS-EQLmsfnffLFSLFVIGCGLTFLETA 126
Cdd:cd17328 34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLssFAPNfWQL------LLFRALVGIGEASYSPI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 127 ANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGmLLFSGNGDANIALpyTVMGVI-VLSVALIFFRIRLPEINHDD 205
Cdd:cd17328 108 APTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGG-LVAQATGGWRWAF--RVTGVLgVLLAILLLLFVREPPRGAAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 206 CEDTTAEA----KAGLKGLWKHRCFTWGVMALFCYEIAEISINSF---FINYVTDDGWMDAHDAAIVLSFGGLGLFMIGR 278
Cdd:cd17328 185 GGVMAKSTatsfLADLKALAKNPSFILSTLGFTAVSFVTGALAFWaptFFLRAFGVGDLSSADVGLIFGAITCIAGVLGV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 279 IIGSWIMSYIRAEKV---LFICAIFTVLGA--LFVTLNLGTLSKGALFAC----YIFEAIMFPTIFAIsLRGLGDYTKRA 349
Cdd:cd17328 265 LLGGILADRLRRKTPradPLVCAVGLLAAApfLFLALVLALSNLLLAWVLlflgEFLLSLNWAPVFAI-LLYVVIPTRRS 343
|
330 340
....*....|....*....|....*...
gi 495421578 350 SS----FLMMSPIGGAVGPLLMGYVADI 373
Cdd:cd17328 344 TAsaiqILLSHLLGDAGSPYLIGLISDL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
42-391 |
2.71e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.53 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 42 QEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLfipseqlMSFNFFLFSLFVIGCGLT 121
Cdd:cd17475 23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL-------MALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 122 FLETAANPYVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNGDANIALPYTVMGVIVLSVALIFFRIRLPEI 201
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 202 NHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGlFMIGRIIG 281
Cdd:cd17475 176 AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLG-GALGRIGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 282 SWIMSYI---RAEKVLFICAIFTVLGALFVTLNLGTLSKGALFACYIFEAImfptiFAISLRGLG----------DYTKR 348
Cdd:cd17475 255 GRVSDRVfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGL-----FAIGWNGLYltlvaesagpEQAGT 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 495421578 349 ASSF-LMMSPIGGAVGPLLMGYVADiSTMSFSFVVPLFGYAVVL 391
Cdd:cd17475 330 ALGLaNTINFIGIAIGPPLFGLLVD-ATHSYAPAWLALALLLVL 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-193 |
4.32e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 17 FVLVTSLFFLWGFA-HAILDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSL 95
Cdd:cd17316 179 TLLLILLWFFISFGyYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 96 LFipseqLMSFNFFLFSLFVIGCGLTFLETAANP----YVTELGDRETAASRLNLAQSFNGLGCICAPVIGGMLLFSGNG 171
Cdd:cd17316 259 PL-----FYLLSGSPTLLLLLLFILSFFVGGVWGalyaYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|..
gi 495421578 172 DANIAlpYTVMGVIVLSVALIF 193
Cdd:cd17316 334 TGVPA--LILALLAIVALIVAL 353
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
22-374 |
5.96e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 5.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 22 SLFFLWGFAHAIlDVLNKHFQEALVMTKAHSALIQATMYTGYFTMAIPAGLFINKYGYRQGVVFGLILYGIGSLLFIPSE 101
Cdd:cd17352 11 VNFFTDGILNSF-GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 102 QLMSFNFFLFSLFVIGCGLTFLetaanPYVTELG----DRETAASRLNLAQSfnGLGCICAPVIGGMLLfsGNGDANIAL 177
Cdd:cd17352 90 SLWQLYLTYGVLGGLGLGLIYS-----PAIVIVGqyfeKKRGLATGIAVAGS--GVGTFVFPPLLRYLL--DNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 178 pyTVMGVIVLSVALIFFRIRlpeinhddcedttaeakaglkgLWKHRCFTWGVMALFCYEIAEISINSFFINYVTDDGwM 257
Cdd:cd17352 161 --LILGGLCLNLCVCGLLLR----------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLG-I 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 258 DAHDAAIVLSFGGlGLFMIGRIIGSWI--MSYIRAEKVLFICAIFTVLGALFVTLNLGTLSKGALFACY-----IFEAIM 330
Cdd:cd17352 216 DESDAAFLLSIIG-ISDIVGRILLGLLadKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFgfcsgSYSSLT 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 495421578 331 FPTIFAISlrGLGDYTKRASSFLMMSPIGGAVGPLLMGYVADIS 374
Cdd:cd17352 295 PVILADLV--GLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
160-316 |
6.09e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 160 VIGGMLLFSGNGDANIALPYTVMGVIVLSVAL-IFFRIRLPEINHDDCEDTTAEAKAGLKGLWKHRCFTWGVMALFCYEI 238
Cdd:cd17485 142 LLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLpVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKL 221
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495421578 239 AEISINSFFINYVTDDGWmDAHDAAIVLSFGGLGLFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLNLGTLS 316
Cdd:cd17485 222 GEQGALAMLPPFLVDRGF-SLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGS 298
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
82-392 |
8.55e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 37.99 E-value: 8.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 82 GVVFGLILYGIGSLLFIpseqLMSFNFFLFSLFVIGCGLTFLETAAN----PYVTELGD------RETAasrLNLAQSFN 151
Cdd:cd17313 78 LAALGLILIPNAADIGL----ALGDGPRTWALVLFVLGIVLLDFAMNvcqgPVRALLPDlvppeqRSKA---NGIINFMG 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 152 GLGCICAPVIGGMLL----FSGNGDANIALPYTVmGVIVLSVALIFFRIRLPEINHDDCEDTTAEAKAG---LKGLWKHR 224
Cdd:cd17313 151 GLGGVLGYLLGAILWdhnwFGFALGGNLKVPFYI-GAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLgevLKSLLKLL 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 225 CFTWGVM-----ALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVL----SFGGLGL------FMIGRIIGSWIMSYIR 289
Cdd:cd17313 230 KIMPRSLlrlllVIFFWWIAFFPFELFFTDYMGEEVYHGTSAASSHYgagvRMGAWGLlifslaFLIFSLPIGKLGKKIG 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 290 AEKVLFICAIFTVLGALFVTLnlgTLSKGALFACYIFEAIMFPTIFAISL-----------RGLGDYTKRASSFLMMSPI 358
Cdd:cd17313 310 RKKVYLIGLVLFAVGMALMAL---VHNVTVALVLFALGGIGWATININPYplvsdyhsesgRGQGTDTGLLNLAISLAQI 386
|
330 340 350
....*....|....*....|....*....|....
gi 495421578 359 ggaVGPLLMGYVADISTMSFSFVVPLFGYAVVLI 392
Cdd:cd17313 387 ---LVSLLAGPIIDVKGYGTVFPVAAVASFLSLV 417
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-397 |
9.17e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 37.78 E-value: 9.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 232 ALFCYEIAEISINSFFINYVTDDGWMDAHDAAIVLSFGGLGlFMIGRIIGSWIMSYIRAEKVLFICAIFTVLGALFVTLN 311
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLG-YALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495421578 312 LGTLskgALFACYIFEAIMFPTIFAISLRGLGDYTKRA------SSFLMMSPIGGAVGPLLMGYVADISTMSFSFVVPLF 385
Cdd:pfam07690 83 SSLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEergralGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|..
gi 495421578 386 GYAVVLIYSYMV 397
Cdd:pfam07690 160 LSLLAAVLLLLP 171
|
|
| |
