|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
700-1102 |
7.56e-170 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 507.53 E-value: 7.56e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 700 AFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSG 779
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 780 VYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQG 859
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 860 HTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLR 939
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 940 ILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTG 1019
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1020 ECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWD 1099
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
...
gi 495460697 1100 VST 1102
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
616-1018 |
1.41e-167 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 501.75 E-value: 1.41e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 616 AFSRDGKTLASGSADHTVKLWQVSDGSCLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGC 695
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 696 VRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTG 775
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 776 HSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLK 855
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 856 TWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTG 935
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 936 KCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWD 1015
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
...
gi 495460697 1016 VST 1018
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
742-1144 |
3.39e-167 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 500.59 E-value: 3.39e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 742 AFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQ 821
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 822 IFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHG 901
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 902 HTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVS 981
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 982 TLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWDLSTG 1061
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1062 ECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWDVSTGECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWD 1141
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
...
gi 495460697 1142 TKT 1144
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
658-1060 |
1.17e-166 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 499.05 E-value: 1.17e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 658 AFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSG 737
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 738 VRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHG 817
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 818 HTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCIS 897
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 898 ILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTG 977
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 978 DCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWD 1057
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
...
gi 495460697 1058 LST 1060
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
574-976 |
2.30e-163 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 490.58 E-value: 2.30e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 574 AFSPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVKLWQVSDGSCLQTCTGHTDE 653
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 654 VFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTG 733
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 734 HTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLK 813
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 814 TLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSD 893
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 894 RCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWD 973
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
...
gi 495460697 974 QRT 976
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
532-934 |
4.51e-157 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 474.40 E-value: 4.51e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 532 DFYGLTVWQANLQGLKLHNVNFAGCDLAGSVFTETLGNMLSAAFSPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNW 611
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 612 VRSVAFSRDGKTLASGSADHTVKLWQVSDGSCLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTG 691
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 692 HTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVS 771
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 772 THTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTG 851
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 852 QCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWD 931
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
...
gi 495460697 932 IKT 934
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
784-1153 |
2.39e-149 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 453.98 E-value: 2.39e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 784 AFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDW 863
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 864 VFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHG 943
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 944 HTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLK 1023
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1024 TLQGHGNRVKSVAFSPKDNILASCSTDETIRLWDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWDVSTG 1103
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 495460697 1104 ECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWDTKTGKCLKILRA 1153
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
826-1154 |
2.43e-126 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 393.51 E-value: 2.43e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 826 AFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAH 905
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 906 VCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEG 985
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 986 HTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWDLSTGECSK 1065
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1066 LLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWDVSTGECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWDTKTG 1145
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
....*....
gi 495460697 1146 KCLKILRAP 1154
Cdd:COG2319 321 KLLRTLTGH 329
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
811-1099 |
1.68e-116 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 363.19 E-value: 1.68e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 811 CLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDY 890
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 891 HSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVR 970
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 971 LWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTD 1050
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495460697 1051 ETIRLWDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWD 1099
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
769-1057 |
4.08e-116 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 362.04 E-value: 4.08e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 769 CVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDW 848
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 849 GTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIR 928
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 929 LWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTD 1008
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495460697 1009 QTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWD 1057
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
853-1141 |
1.71e-114 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 357.80 E-value: 1.71e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 853 CLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDI 932
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 933 KTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVR 1012
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1013 LWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHD 1092
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495460697 1093 QTVKVWDVSTGECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWD 1141
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
728-1015 |
1.04e-111 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 350.10 E-value: 1.04e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 728 VRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYH 807
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 808 TGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRL 887
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 888 WDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQ 967
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 495460697 968 TVRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWD 1015
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
606-889 |
2.82e-111 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 348.94 E-value: 2.82e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 606 EGHTNWVRSVAFSRDGKTLASGSADHTVKLWQVSDGSCLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQC 685
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 686 LNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDAR 765
Cdd:cd00200 86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 766 TGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRL 845
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 495460697 846 WDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWD 889
Cdd:cd00200 246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
685-973 |
3.16e-109 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 343.55 E-value: 3.16e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 685 CLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDA 764
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 765 RTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVR 844
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 845 LWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRD 924
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495460697 925 ETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWD 973
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
643-931 |
6.71e-107 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 337.38 E-value: 6.71e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 643 CLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDA 722
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 723 STGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVR 802
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 803 LWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSND 882
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 495460697 883 NTVRLWDYHSDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWD 931
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
572-847 |
5.41e-100 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 318.90 E-value: 5.41e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 572 SAAFSPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVKLWQVSDGSCLQTCTGHT 651
Cdd:cd00200 14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 652 DEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTC 731
Cdd:cd00200 94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 732 TGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGIC 811
Cdd:cd00200 174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
|
250 260 270
....*....|....*....|....*....|....*.
gi 495460697 812 LKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWD 847
Cdd:cd00200 254 VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
895-1153 |
2.78e-98 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 314.27 E-value: 2.78e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 895 CISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQ 974
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 975 RTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIR 1054
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1055 LWDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWDVSTGECRHTCTGHTHLISSVAFSGDGQIVASGSQD 1134
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250
....*....|....*....
gi 495460697 1135 QTVRLWDTKTGKCLKILRA 1153
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSG 259
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
568-805 |
1.09e-83 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 274.21 E-value: 1.09e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 568 GNMLSAAFSPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVKLWQVSDGSCLQTC 647
Cdd:cd00200 52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 648 TGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSW 727
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495460697 728 VRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWD 805
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
994-1155 |
2.05e-37 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 145.82 E-value: 2.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 994 AFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWDLSTGECSKLLRGHNNW 1073
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1074 VFSVAFSPDGNTIASGSHDQTVKVWDVSTGECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWDTKTGKCLKILRA 1153
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
..
gi 495460697 1154 PR 1155
Cdd:COG2319 161 HS 162
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
906-1137 |
2.99e-20 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 97.08 E-value: 2.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 906 VCSVAFSTDGKTVASSSRDETIRLWDiktgkCLRILHGHTDWIYSVT-FSGDGK------------TLASGSADQTVRLW 972
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFE-----CESIIKDGRDIHYPVVeLASRSKlsgicwnsyiksQVASSNFEGVVQVW 560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 973 DQRTGDCVSTLEGHTNQIWSVAFSS-DGKTLASSNTDQTVRLWDVSTGECLKTLQGHGNrVKSVAFsPKDN--ILASCST 1049
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF-PSESgrSLAFGSA 638
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1050 DETIRLWDLSTGE---CSKLlrGHNNWVFSVAFSpDGNTIASGSHDQTVKVWDVSTGEC------RHTCTGHTHLISSVA 1120
Cdd:PLN00181 639 DHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVG 715
|
250
....*....|....*..
gi 495460697 1121 FSGDGQIVASGSQDQTV 1137
Cdd:PLN00181 716 LSVSDGYIATGSETNEV 732
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
609-820 |
1.21e-18 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 92.07 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 609 TNWVRSVAFSRDGKTLASGSADHTVKLWQ----VSDGSCLQTCT---GHTDEVFSVAFNPQGNTLISGSS-DHTVILWDG 680
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHYPVvelASRSKLSGICWNSYIKSQVASSNfEGVVQVWDV 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 681 DTGQCLNRFTGHTGCVRSVAFST-DGKTLASGSDDHTVILWDASTGSWVRTCTGhTSGVRSVAFSTD-GNTLASGSNDHT 758
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSEsGRSLAFGSADHK 641
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495460697 759 VRLWDARTGSC-VSTHTGHSSGVYSVAFsTDGKTLATGSGDHTVRLWDYH---TGICLKTLH---GHTN 820
Cdd:PLN00181 642 VYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSmsiSGINETPLHsfmGHTN 709
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
861-1098 |
1.55e-18 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 91.69 E-value: 1.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 861 TDWVFPVAFSPDGKTLASGSNDNTVRLWDyhsdrCISILH-GHTAHVCSVAFSTDGK------------TVASSSRDETI 927
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFE-----CESIIKdGRDIHYPVVELASRSKlsgicwnsyiksQVASSNFEGVV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 928 RLWDIKTGKCLRILHGHTDWIYSVTFS-GDGKTLASGSADQTVRLWDQRTGDCVSTLEGHTNqIWSVAFSSD-GKTLASS 1005
Cdd:PLN00181 558 QVWDVARSQLVTEMKEHEKRVWSIDYSsADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFG 636
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1006 NTDQTVRLWDVSTGEC-LKTLQGHGNRVKSVAFSpKDNILASCSTDETIRLWDLSTGEC----SKL--LRGHNNWVFSVA 1078
Cdd:PLN00181 637 SADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISgineTPLhsFMGHTNVKNFVG 715
|
250 260
....*....|....*....|
gi 495460697 1079 FSPDGNTIASGSHDQTVKVW 1098
Cdd:PLN00181 716 LSVSDGYIATGSETNEVFVY 735
|
|
| COG3903 |
COG3903 |
Predicted ATPase [General function prediction only]; |
129-409 |
1.93e-17 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443109 [Multi-domain] Cd Length: 933 Bit Score: 88.15 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 129 LVALLGMGGIGKTTLAVKLAHLLQDKFE----FVmwrSLRNAPPLEEVLADMIQFLSVQQETNLPSSVdgkilRLIQYLQ 204
Cdd:COG3903 178 LVTLTGPGGVGKTRLALEVAHRLADRFPdgvwFV---DLAGVTDPALVLAAVARALGVRDAPGRDPAA-----RLRAALA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 205 TARCLLVLDNTESILESGSrtggyregyagygELLRTI-GETSHNSCLVmTSREPpqdLNIlEGEA-LPVRcfPLkGLPE 282
Cdd:COG3903 250 DRRLLLVLDNCEHVVDAAA-------------ALVRPLlPAAPGLRVLA-TSREP---LGL-PGERvLPLP--PL-AVPP 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 283 THGQ-------EIFKE-----KGHFIGDDTQWMTLIE---RYAGNPLALKMVACAVRDFfdsNIAQF-------LDFLKE 340
Cdd:COG3903 309 PGAEalaseavALFVEragaaRPGFALDAAEAAAVAEicrRLDGLPLAIELAAARLRTL---SLAELaarlddrLRLLTG 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 341 GSfifddiRDLLDRH----------FQRLTSTEKELMYWLAINREPISLEElqedfVCYLCA----TDILEAVGSLQRRS 406
Cdd:COG3903 386 GR------RDAPPRHrtlraaldwsYDLLSPAERRLLRRLSVFPGGFTLEA-----AEAVCGgdgpADVLDLLAALVDKS 454
|
...
gi 495460697 407 LIE 409
Cdd:COG3903 455 LLE 457
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
122-864 |
2.24e-14 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 78.31 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 122 ILQDNCCLVALLGMGGIGKTTLAVKLAHLLQDKFE-----FVMW---RSLRNAPPLEEVLADMIQflsvqqetNLPSSVD 193
Cdd:COG5635 175 LLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLdaedpIPILielRDLAEEASLEDLLAEALE--------KRGGEPE 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 194 GKILRLiqyLQTARCLLVLDNTESILESGSRTGGYREgyagygelLRTIGETSHNSCLVMTSREPPQDLNILEGealpVR 273
Cdd:COG5635 247 DALERL---LRNGRLLLLLDGLDEVPDEADRDEVLNQ--------LRRFLERYPKARVIITSRPEGYDSSELEG----FE 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 274 CFPLKGLPETHGQEIFKEKGHFIGDDTQ--WMTL-----IERYAGNPLALKMVA--CAVRDFFDSNIAQFLD-----FLK 339
Cdd:COG5635 312 VLELAPLSDEQIEEFLKKWFEATERKAErlLEALeenpeLRELARNPLLLTLLAllLRERGELPDTRAELYEqfvelLLE 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 340 EgsfiFDDIRDLLDRhfQRLTSTEK-ELMYWLAI-----NREPISLEELQEDFVCYLC----ATDILEAVgsLQRRSLIE 409
Cdd:COG5635 392 R----WDEQRGLTIY--RELSREELrELLSELALamqenGRTEFAREELEEILREYLGrrkdAEALLDEL--LLRTGLLV 463
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 410 KTSTG---FTQQpVVMEYMINRLIEQIPEEIISQNITIFRTHSLLKASAPDYVRDAQVCLILEPIIEKLLSSFGSTKQLE 486
Cdd:COG5635 464 ERGEGrysFAHR-SFQEYLAARALVEELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALAL 542
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 487 NHLLEILSMLRAPTPGVKKSTLQMGYVSGNTINLLSQLQIDLNGYD--FYGLTVWQANLQGLKLHNVNFAGCDLAGSVFT 564
Cdd:COG5635 543 AAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALllALLALDLGLAALLLLLLLLLLLLLLLALALLL 622
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 565 ETLGNMLSAAFSPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVKLWQVSDGSCL 644
Cdd:COG5635 623 ALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALA 702
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 645 QTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWDA-- 722
Cdd:COG5635 703 LALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVll 782
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 723 -STGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTV 801
Cdd:COG5635 783 lALALLASLLLALLLLILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALELARASLGASLVLLALLLATLL 862
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495460697 802 RLWDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWV 864
Cdd:COG5635 863 LLLLLLLALALALLSLLSLSSLALLSLLGLLLALSLLALLLLSLSLALAALLLAAREALTLDR 925
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
777-1009 |
2.33e-14 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 77.82 E-value: 2.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 777 SSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGIC-LKTLH------GHTNQIFSVAFSPEGNTLVCVS-LDQTVRLWDW 848
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKdGRDIHypvvelASRSKLSGICWNSYIKSQVASSnFEGVVQVWDV 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 849 GTGQCLKTWQGHTDWVFPVAFSP-DGKTLASGSNDNTVRLWDYHSDRCISILHGhTAHVCSVAFSTD-GKTVASSSRDET 926
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSEsGRSLAFGSADHK 641
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 927 IRLWDIKTGK---CLRIlhGHTDWIYSVTFSgDGKTLASGSADQTVRLWDQRTGDC------VSTLEGHTNQIWSVAFS- 996
Cdd:PLN00181 642 VYYYDLRNPKlplCTMI--GHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSv 718
|
250
....*....|...
gi 495460697 997 SDGKTLASSNTDQ 1009
Cdd:PLN00181 719 SDGYIATGSETNE 731
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
648-809 |
9.13e-12 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 66.26 E-value: 9.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 648 TGHTDEVFSVAFNPQGNTL-ISGSSDHTVILWDGDTGQCLNRFTGHTGCvRSVAFSTDGKTL-ASGSDDHTVILWDASTG 725
Cdd:COG3391 64 AAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 726 SWVRTC-TGhtSGVRSVAFSTDGNTL-ASGSNDHT----VRLWDARTGSCVST-HTGhsSGVYSVAFSTDGKTL------ 792
Cdd:COG3391 143 KVVATIpVG--AGPHGIAVDPDGKRLyVANSGSNTvsviVSVIDTATGKVVATiPVG--GGPVGVAVSPDGRRLyvanrg 218
|
170
....*....|....*....
gi 495460697 793 --ATGSGDHTVRLWDYHTG 809
Cdd:COG3391 219 snTSNGGSNTVSVIDLATL 237
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
864-986 |
9.17e-12 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 69.15 E-value: 9.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 864 VFPVAFSP-DGKTLASGSNDNTVRLWDYHSDRC-------ISILHGHTAHVCSVAFSTDGKTV-ASSSRDETIRLWDIKT 934
Cdd:PTZ00421 78 IIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMNVlASAGADMVVNVWDVER 157
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 495460697 935 GKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGH 986
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
934-973 |
2.73e-11 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 59.25 E-value: 2.73e-11
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 934 TGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWD 973
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
850-889 |
2.98e-11 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 59.25 E-value: 2.98e-11
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 850 TGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWD 889
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1060-1099 |
3.63e-11 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 58.86 E-value: 3.63e-11
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 1060 TGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWD 1099
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
743-1146 |
6.20e-11 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 66.99 E-value: 6.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 743 FSTDGNTLA-----SGSND-HTV--------RLwdartgscvsTHtgHSSGVYSVAFSTDGKTL--ATGSGDHTVRlwdy 806
Cdd:COG4946 68 FSPDGKWIAftsdyDGNTDvYVMpaeggepkRL----------TY--HPANDRVVGWTPDGKSVlfASNRGSPPSR---- 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 807 htgiclktlhghTNQIFSVafSPEGNTlvcvsldqTVRLwDWGtgqclktwqghtdWVFPVAFSPDGKTLASGSNDNTVR 886
Cdd:COG4946 132 ------------SNQLYTV--PVDGGL--------PERL-PLP-------------PAGDGSFSPDGKKLAYTRIGREFR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 887 LWDYHSdrcisilHGHTAHVCSVAFSTD------------------GKTVA-SSSRDETIRLW--DIKTGKCLRILHgHT 945
Cdd:COG4946 176 TWKRYR-------GGTAGDIWIYDLGTGeftrltdfggndrnpmwiGDRIYfLSDRDGTFNLYsyDPDGKDLRQLTH-FK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 946 DWiySVTF-SGDGKTL-------------ASGSADQ-TVRLwdqrTGDCVSTLEGH---TNQIWSVAFSSDGKTLA---- 1003
Cdd:COG4946 248 DF--DVRFpSTDGGRIvyeqggdlylldlASGEPRKlNITL----AGDFPQRRPRWvdvSGYLTSFALSPDGKRVAfear 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1004 -----SSNTDQTVRLWDVSTGEclktlqghgnRVKSVAFSPKDNILASCS--TDETiRLW--DLSTGECSK-LLRGHNNW 1073
Cdd:COG4946 322 gevftVPAEKGPTRNLTNTPGV----------RERLPAWSPDGKSIAYFSdaSGEY-ELYiaPADGSGEPKqLTLGDLGR 390
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495460697 1074 VFSVAFSPDGNTIASGSHDQTVKVWDVSTGECRHTCTG-HTHLISSVAFSGDGQIVA----SGSQDQTVRLWDTKTGK 1146
Cdd:COG4946 391 VFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGK 468
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
1025-1146 |
7.62e-11 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 66.07 E-value: 7.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1025 LQGHGNRVKSVAFSPKDNI-LASCSTDETIRLWDLS----TGECSK---LLRGHNNWVFSVAFSPDG-NTIASGSHDQTV 1095
Cdd:PTZ00421 71 LLGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPeeglTQNISDpivHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 495460697 1096 KVWDVSTGECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWDTKTGK 1146
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
1019-1154 |
8.21e-11 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 65.09 E-value: 8.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1019 GECLKTLQghgnrvksvafSPKDNILASCST-DETIRLWDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKV 1097
Cdd:pfam20426 82 AQCFATLQ-----------TPSENFLISCGNwENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1098 WDVSTGEC-----------------------RHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWDTKTGKCLKILRAP 1154
Cdd:pfam20426 151 WEVLRGRSsekrsrntqtefprkdhviaetpFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHP 230
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
655-886 |
9.51e-11 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 63.88 E-value: 9.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 655 FSVAFNPQGNTLISGSSDHTVILWD---------GDTGQCLNRFTGHTGcvrsVAFSTDGKTLASGSDDHTVILWDAStG 725
Cdd:cd05819 11 QGIAVDSSGNIYVADTGNNRIQVFDpdgnfitsfGSFGSGDGQFNEPAG----VAVDSDGNLYVADTGNHRIQKFDPD-G 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 726 SWVRTC------TGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDArTGSCVSTHTGHSSGV------YSVAFSTDGKTLA 793
Cdd:cd05819 86 NFLASFggsgdgDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDP-DGEFLTTFGSGGSGPgqfngpTGVAVDSDGNIYV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 794 TGSGDHTVRLWDYhTGICLKTL------HGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWD------WGTGQCLKTWqGHT 861
Cdd:cd05819 165 ADTGNHRIQVFDP-DGNFLTTFgstgtgPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDpdgagfGGNGNFLGSD-GQF 242
|
250 260
....*....|....*....|....*
gi 495460697 862 DWVFPVAFSPDGKTLASGSNDNTVR 886
Cdd:cd05819 243 NRPSGLAVDSDGNLYVADTGNNRIQ 267
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
576-720 |
1.16e-10 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 65.88 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 576 SPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNwVRSVAFSRD-GKTLASGSADHTVKLWQVSDGScLQTCT--GHTD 652
Cdd:PLN00181 585 SADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPK-LPLCTmiGHSK 662
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495460697 653 EVFSVAFnPQGNTLISGSSDHTVILWD------GDTGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILW 720
Cdd:PLN00181 663 TVSYVRF-VDSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
935-973 |
1.69e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 56.97 E-value: 1.69e-10
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 935 GKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWD 973
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
766-805 |
2.15e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.55 E-value: 2.15e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 766 TGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWD 805
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
682-721 |
2.17e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.55 E-value: 2.17e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 682 TGQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWD 721
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1018-1057 |
2.56e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.55 E-value: 2.56e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 1018 TGECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWD 1057
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
649-779 |
2.75e-10 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 64.14 E-value: 2.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 649 GHTDEVFSVAFNPQGNT-LISGSSDHTVILW----DGDTGQCLN---RFTGHTGCVRSVAFSTDGK-TLASGSDDHTVIL 719
Cdd:PTZ00421 73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWgipeEGLTQNISDpivHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 720 WDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSG 779
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1061-1099 |
3.13e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 56.20 E-value: 3.13e-10
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 1061 GECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWD 1099
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
640-679 |
4.02e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.78 E-value: 4.02e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 640 DGSCLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWD 679
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
688-1084 |
4.87e-10 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 64.29 E-value: 4.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 688 RFTGHTGCVRSVAFSTDGKTLA-SGSDD-----HTVilwDASTGSwVRTCTGHTSGVRSVAFSTDGNTL--ASGSNDHTV 759
Cdd:COG4946 55 RLTSHPGYESFPRFSPDGKWIAfTSDYDgntdvYVM---PAEGGE-PKRLTYHPANDRVVGWTPDGKSVlfASNRGSPPS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 760 RLWDARTgscVSTHTGHSS-----GVYSVAFSTDGKTLATGSGDHTVRLWDYHTGIclktlhghtnqifsvafspegntl 834
Cdd:COG4946 131 RSNQLYT---VPVDGGLPErlplpPAGDGSFSPDGKKLAYTRIGREFRTWKRYRGG------------------------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 835 vcvsldQTVRLW--DWGTgqclKTWQGHTDW----VFPV-------------------AFSPDGKTL------------- 876
Cdd:COG4946 184 ------TAGDIWiyDLGT----GEFTRLTDFggndRNPMwigdriyflsdrdgtfnlySYDPDGKDLrqlthfkdfdvrf 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 877 ASGSNDNTV-----RLWDY----HSDRCISI-LHG-----------HTAHVCSVAFSTDGKTVASSSRDE---------- 925
Cdd:COG4946 254 PSTDGGRIVyeqggDLYLLdlasGEPRKLNItLAGdfpqrrprwvdVSGYLTSFALSPDGKRVAFEARGEvftvpaekgp 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 926 TIRLwdiktgkclrilhGHTDWI--YSVTFSGDGKTLA-----SGSADqtvrLW--DQRTGDCVSTL-EGHTNQIWSVAF 995
Cdd:COG4946 334 TRNL-------------TNTPGVreRLPAWSPDGKSIAyfsdaSGEYE----LYiaPADGSGEPKQLtLGDLGRVFNPVW 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 996 SSDGKTLASSNTDQTVRLWDVSTGECLKTLQG-HGNRVKSVAFSPkDN--ILASCSTDET---IRLWDLSTGECSKLLRG 1069
Cdd:COG4946 397 SPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSP-DSkwLAYSKPGPNQlsqIFLYDVETGKTVQLTDG 475
|
490
....*....|....*
gi 495460697 1070 HNNWvFSVAFSPDGN 1084
Cdd:COG4946 476 RYDD-GSPAFSPDGK 489
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
724-763 |
5.83e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.40 E-value: 5.83e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 724 TGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWD 763
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1102-1141 |
6.95e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.40 E-value: 6.95e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 1102 TGECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWD 1141
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
767-805 |
7.19e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 55.04 E-value: 7.19e-10
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 767 GSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWD 805
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
985-1143 |
9.97e-10 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 62.60 E-value: 9.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 985 GHTNQIWSVAFSS-DGKTLASSNTDQTVRLWDV-------STGECLKTLQGHGNRVKSVAFSPK-DNILASCSTDETIRL 1055
Cdd:PTZ00421 73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSaMNVLASAGADMVVNV 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1056 WDLSTGECSKLLRGHNNWVFSVAFSPDGNTIASGSHDQTVKVWDVStgECRHTCTGHTH---------------LISSVA 1120
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR--DGTIVSSVEAHasaksqrclwakrkdLIITLG 230
|
170 180
....*....|....*....|...
gi 495460697 1121 FSGdgqivasgSQDQTVRLWDTK 1143
Cdd:PTZ00421 231 CSK--------SQQRQIMLWDTR 245
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
683-721 |
1.14e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 54.66 E-value: 1.14e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 683 GQCLNRFTGHTGCVRSVAFSTDGKTLASGSDDHTVILWD 721
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
851-889 |
1.60e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 54.27 E-value: 1.60e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 851 GQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWD 889
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
898-1057 |
2.08e-09 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 61.45 E-value: 2.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 898 ILHGHTAHVCSVAFST-DGKTVASSSRDETIRLWDI-------KTGKCLRILHGHTDWIYSVTFSGDGK-TLASGSADQT 968
Cdd:PTZ00421 70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 969 VRLWDQRTGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQGH--GNRVKSVAFSPKDNILA- 1045
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasAKSQRCLWAKRKDLIITl 229
|
170
....*....|....
gi 495460697 1046 SCSTDET--IRLWD 1057
Cdd:PTZ00421 230 GCSKSQQrqIMLWD 243
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
808-847 |
2.18e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.86 E-value: 2.18e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 808 TGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWD 847
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
598-636 |
2.53e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.86 E-value: 2.53e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 598 TGKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVKLW 636
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
725-763 |
2.54e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 53.50 E-value: 2.54e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 725 GSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWD 763
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
976-1015 |
3.10e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.47 E-value: 3.10e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 976 TGDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWD 1015
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1019-1057 |
4.06e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 53.12 E-value: 4.06e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 1019 GECLKTLQGHGNRVKSVAFSPKDNILASCSTDETIRLWD 1057
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1103-1141 |
4.14e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 53.12 E-value: 4.14e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 1103 GECRHTCTGHTHLISSVAFSGDGQIVASGSQDQTVRLWD 1141
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
977-1015 |
5.24e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 52.73 E-value: 5.24e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 977 GDCVSTLEGHTNQIWSVAFSSDGKTLASSNTDQTVRLWD 1015
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
641-679 |
6.19e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 52.73 E-value: 6.19e-09
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 641 GSCLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWD 679
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
914-1061 |
6.97e-09 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 57.78 E-value: 6.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 914 DGKTV-ASSSRDETIRLWDIKTGKCLRILHGHTDWiYSVTFSGDGKTL-ASGSADQTVRLWDQRTGDCVSTLEGHtNQIW 991
Cdd:COG3391 78 DGRRLyVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVG-AGPH 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 992 SVAFSSDGKTLASSNTDQT-----VRLWDVSTGECLKTLQGhGNRVKSVAFSPKDNIL--------ASCSTDETIRLWDL 1058
Cdd:COG3391 156 GIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPV-GGGPVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDL 234
|
...
gi 495460697 1059 STG 1061
Cdd:COG3391 235 ATL 237
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
599-636 |
8.97e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 51.96 E-value: 8.97e-09
10 20 30
....*....|....*....|....*....|....*...
gi 495460697 599 GKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVKLW 636
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
892-931 |
1.30e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 51.54 E-value: 1.30e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 495460697 892 SDRCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWD 931
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
809-847 |
2.96e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.81 E-value: 2.96e-08
10 20 30
....*....|....*....|....*....|....*....
gi 495460697 809 GICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWD 847
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
894-931 |
3.53e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.42 E-value: 3.53e-08
10 20 30
....*....|....*....|....*....|....*...
gi 495460697 894 RCISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWD 931
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
867-1008 |
8.22e-08 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 56.97 E-value: 8.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 867 VAFSPDGKTLA-----SGSNDntvrLWDYHSDRC---ISILHGHTAHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCL 938
Cdd:COG4946 348 PAWSPDGKSIAyfsdaSGEYE----LYIAPADGSgepKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVR 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 939 RILHG-HTDWIYSVTFSGDGKTLA----SGSADQTVRLWDqrtgdcVSTLEGHtnQI-------WSVAFSSDGKTLA-SS 1005
Cdd:COG4946 424 KVDTDgYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYD------VETGKTV--QLtdgryddGSPAFSPDGKYLYfLS 495
|
...
gi 495460697 1006 NTD 1008
Cdd:COG4946 496 SRD 498
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
998-1145 |
1.35e-07 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 53.93 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 998 DGKTLASSNT-DQTVRLWDVSTGECLKTLQgHGNRVKSVAFSPKDN-ILASCSTDETIRLWDLSTGecsKLLR--GHNNW 1073
Cdd:COG3391 78 DGRRLYVANSgSGRVSVIDLATGKVVATIP-VGGGPRGLAVDPDGGrLYVADSGNGRVSVIDTATG---KVVAtiPVGAG 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1074 VFSVAFSPDGNTI---ASGSHDQT--VKVWDVSTGECRHTCTGHTHlISSVAFSGDGQIV--------ASGSQDQTVRLW 1140
Cdd:COG3391 154 PHGIAVDPDGKRLyvaNSGSNTVSviVSVIDTATGKVVATIPVGGG-PVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVI 232
|
....*
gi 495460697 1141 DTKTG 1145
Cdd:COG3391 233 DLATL 237
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
111-320 |
1.72e-07 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 53.54 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 111 RMQELNTLQEWILQ-DNCCLVALLGMGGIGKTTLAVKLAH---LLQDKFEFVMWRSLRNAPPLEEVLADMIQFLSVQQ-E 185
Cdd:pfam00931 1 REDMVEKVIGKLSEkDEPGIVGIHGMGGVGKTTLAAQIFNdfdEVEGHFDSVAWVVVSKTFTISTLQQTILQNLGLSEdD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 186 TNLPSSVDGKiLRLIQYLQTARCLLVLDN--TESILESGSRTGGYREgyagygellrtigetshNSCLVM-TSReppqDL 262
Cdd:pfam00931 81 WDNKEEGELA-RKIRRALLTKRFLLVLDDvwDEEDWDKIGIPLPDRE-----------------NGCRVLlTTR----SE 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495460697 263 NIleGEALPVRCFPLK--GLPETHGQEIFKEKGhFIGDDTQWMTL-------IERYAGNPLALKMVA 320
Cdd:pfam00931 139 EV--AGRVGGPSDPHEveLLEPDEAWELFENKV-FPKTLGECELLedvakeiVEKCRGLPLALKVLG 202
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
715-935 |
2.45e-07 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 53.16 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 715 HTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTL-A 793
Cdd:COG3391 5 SSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 794 TGSGDHTVRLWDYHTGICLKTLHGHTNqIFSVAFSPEGNTL-VCVSLDQTVRLWDWGTGQCLKTWQGHtDWVFPVAFSPD 872
Cdd:COG3391 85 ANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPD 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495460697 873 GKTL-ASGSNDNT----VRLWDYHSDRCI-SILHGHTAHvcSVAFSTDGKTV--------ASSSRDETIRLWDIKTG 935
Cdd:COG3391 163 GKRLyVANSGSNTvsviVSVIDTATGKVVaTIPVGGGPV--GVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDLATL 237
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1035-1122 |
4.15e-07 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 49.20 E-value: 4.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1035 VAFSPKDNILASCSTDETI--------RLWDLSTGecskllrGHNNWVFSVAFSPDGNTIASGSHDQTVKVWDVSTGECR 1106
Cdd:pfam12894 1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLSPD-------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
|
90
....*....|....*.
gi 495460697 1107 HTCTGHTHLISSVAFS 1122
Cdd:pfam12894 74 HHFSAGSDLITCLGWG 89
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
736-977 |
7.95e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 51.94 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 736 SGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGIcLKT- 814
Cdd:COG4257 17 SGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE-ITTf 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 815 -LHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQcLKTWQGHTDWVFP--VAFSPDGKTLASGSNDNTVRLWDYH 891
Cdd:COG4257 96 aLPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPygIAVDPDGNLWVTDFGANAIGRIDPD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 892 SDRcISILHGHT--AHVCSVAFSTDGKTVASSSRDETIRLWDIKTGKCLRI-LHGHTDWIYSVTFSGDGKTLASGSADQT 968
Cdd:COG4257 175 TGT-LTEYALPTpgAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYpLPGGGARPYGVAVDGDGRVWFAESGANR 253
|
....*....
gi 495460697 969 VRLWDQRTG 977
Cdd:COG4257 254 IVRFDPDTE 262
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
691-805 |
1.10e-06 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 52.59 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 691 GHTGCVRSVAFST-DGKTLASGSDDHTVILWDASTGSWVRTCT-------GHTSGVRSVAFSTDG-NTLASGSNDHTVRL 761
Cdd:PTZ00421 73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHTKKVGIVSFHPSAmNVLASAGADMVVNV 152
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 495460697 762 WDARTGSCVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWD 805
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
|
|
| WDR74 |
cd22857 |
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ... |
750-1062 |
1.46e-06 |
|
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.
Pssm-ID: 439303 [Multi-domain] Cd Length: 325 Bit Score: 51.46 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 750 LASGSNDHTVRLWDARTGSCVSTHTGHSSGVysvafstdgktlATGSGDHTVRLWDYHTGICLKTLHGhtnQIFSVAFSP 829
Cdd:cd22857 47 LAVARKNGTVEVLDPENGDLLASFSDSEPAT------------KLSEEDHFVGLHLFSGTLLTCTSKG---SLRSTKLPD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 830 EgnTLVCVSLdqtvrLWDWGTGQCLKTWQGHtdwvfpvafsPDGKTLASGSNDNTVRLWDyhsdrcisilhghTAHVCSV 909
Cdd:cd22857 112 D--STASSSP-----TAWVCLGGNLLCMRVD----------PNENYFAFGGKEVELNVWD-------------LEEKPGK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 910 AFStdGKTVASSSRDetirlwdiktgkcLRILhghtDWIYSVTF-SGDGKT-LASGSADQTVRLWDQRTGD-CVSTLEGH 986
Cdd:cd22857 162 IWR--AKNVPNDSLG-------------LRVP----VWVTDLTFlSKDDHRkIVTGTGYHQVRLYDTRAQRrPVVSVDFG 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495460697 987 TNQIWSVAFSSDGKTLASSNTDQTVRLWDVSTGECLKTLQG-HGNRVKSVAFSPKDNILASCSTDETIRLWDLSTGE 1062
Cdd:cd22857 223 ETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGkCGGSIRSIARHPELPLIASCGLDRYLRIWDTETRQ 299
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
574-810 |
1.95e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 50.79 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 574 AFSPDGRMLAICDTDFQIRLWHVQTGKLLVICEGHTNWVRSVAFSRDGKTLASGSADHTVklWQVSDGsclqtcTGHTDE 653
Cdd:COG4257 23 AVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRI--GRIDPK------TGEITT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 654 V---------FSVAFNPQGNTLISGSSDHTVIlwdgdtgqclnRFTGHTGCVRSVAFSTDGKT---LASGSDDhtvILW- 720
Cdd:COG4257 95 FalpgggsnpHGIAFDPDGNLWFTDQGGNRIG-----------RLDPATGEVTEFPLPTGGAGpygIAVDPDG---NLWv 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 721 -----------DASTGSwVRTCTGHT--SGVRSVAFSTDGNTLASGSNDHTVRLWDARTGScVSTHT--GHSSGVYSVAF 785
Cdd:COG4257 161 tdfganaigriDPDTGT-LTEYALPTpgAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGT-VTEYPlpGGGARPYGVAV 238
|
250 260
....*....|....*....|....*
gi 495460697 786 STDGKTLATGSGDHTVRLWDYHTGI 810
Cdd:COG4257 239 DGDGRVWFAESGANRIVRFDPDTEL 263
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
697-886 |
2.51e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 50.40 E-value: 2.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 697 RSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGScVSTH--T 774
Cdd:COG4257 20 RDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE-ITTFalP 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 775 GHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGICLKTLHGHTN-QIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQc 853
Cdd:COG4257 99 GGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGGaGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGT- 177
|
170 180 190
....*....|....*....|....*....|....*
gi 495460697 854 LKTWQGHTDWVFP--VAFSPDGKTLASGSNDNTVR 886
Cdd:COG4257 178 LTEYALPTPGAGPrgLAVDPDGNLWVADTGSGRIG 212
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
899-1017 |
3.28e-06 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 48.13 E-value: 3.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 899 LHGHTAHVCSVAFSTDGKTVA-SSSRDETIRLW--DIKTGKCLRILHGHTdWIYSVTFSGDGKTLA-SGSADQTVRLWdq 974
Cdd:COG0823 26 LTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGEPRRLTFGGG-YNASPSWSPDGKRLAfVSRSDGRFDIY-- 102
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 495460697 975 rtgdcVSTLEGH-----TNQIWSVAFSSDGKTLA-SSNTDQTVRLWDVS 1017
Cdd:COG0823 103 -----VLDLDGGaprrlTDGPGSPSWSPDGRRIVfSSDRGGRPDLYVVD 146
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
858-1025 |
5.23e-06 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 50.72 E-value: 5.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 858 QGHTDWVFPVAFSP-DGKTLASGSNDNTVRLWDY-HSDRCIS-------ILHGHTAHVCSVAFS-TDGKTVASSSRDETI 927
Cdd:PTZ00420 71 KGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIpHNDESVKeikdpqcILKGHKKKISIIDWNpMNYYIMCSSGFDSFV 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 928 RLWDIKTGK-CLRILHGHTdwIYSVTFSGDGKTLASGSADQTVRLWDQRTGDCVSTLEGH-----TNQIWSVAFSSDGK- 1000
Cdd:PTZ00420 151 NIWDIENEKrAFQINMPKK--LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHdggknTKNIWIDGLGGDDNy 228
|
170 180
....*....|....*....|....*....
gi 495460697 1001 ---TLASSNTDQTVRLWDV-STGECLKTL 1025
Cdd:PTZ00420 229 ilsTGFSKNNMREMKLWDLkNTTSALVTM 257
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
863-1000 |
6.91e-06 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 50.42 E-value: 6.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 863 WVFPVAFSPDGKTLASGSNDNTVRLWDYHSDRCISILHG-HTAHVCSVAFSTDGKTVASSSRDET----IRLWDIKTGKC 937
Cdd:COG4946 390 RVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVETGKT 469
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495460697 938 LRILHGHTDWiYSVTFSGDGKTLASGSADQTVRLWDQRTGDcvsTLEGHTNQIWSVAFSSDGK 1000
Cdd:COG4946 470 VQLTDGRYDD-GSPAFSPDGKYLYFLSSRDFNPTYGDLDFD---LAFPRTTRIYAVPLRKDAP 528
|
|
| PQQ_ABC_repeats |
TIGR03866 |
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ... |
783-1026 |
6.99e-06 |
|
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.
Pssm-ID: 274824 [Multi-domain] Cd Length: 310 Bit Score: 49.27 E-value: 6.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 783 VAFSTDGKTL-ATGSGDHTVRLWDYHTGICLKTL-HGHTNQIFsvAFSPEGNTL-VCVSLDQTVRLWDWGTGQCLKTWQ- 858
Cdd:TIGR03866 46 ITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLpSGPDPEQF--ALHPNGKILyIANEDDALVTVIDIETRKVLAQIDv 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 859 GhtdwVFP--VAFSPDGKTLASGSNDNTVRLWDYHSDRCI--SILHGhtAHVCSVAFSTDGKTV-ASSSRDETIRLWDIK 933
Cdd:TIGR03866 124 G----VEPegMAVSPDGKIVVNTSETTNMAHWIDTATYEIvdNTLVD--ARPRFAEFTADGKELwVSSEIGGTVTVIDVA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 934 TGKCLR-----ILHGHTDWIYSV--TFSGDGKTL--ASGSADQtvrlwdqrtgdcVSTLEGHTNQI----------WSVA 994
Cdd:TIGR03866 198 TRKVIKkitfaIPGVHPEKVQPVgiKLTKDGKTAfvALGPANR------------VAVVDAKTYEVldyllvgqrvWQLA 265
|
250 260 270
....*....|....*....|....*....|...
gi 495460697 995 FSSDGKTLASSN-TDQTVRLWDVSTGECLKTLQ 1026
Cdd:TIGR03866 266 FTPDESRLLTTNgVSNDVSVIDVAALKVIKSIK 298
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
129-291 |
7.36e-06 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 47.30 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 129 LVALLGMGGIGKTTLAVKLAHLLQD-----KFEFVMWRSLRNAPPLEEV--LADMI--QFLsvqQETNLPSSVDGKILRL 199
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQgklpqGFDFVFFLPCRELSRSGNArsLADLLfsQWP---EPAAPVSEVWAVILEL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 200 IQylqtaRCLLVLDNTESILESGSRTGGYREGYAGYGELLRtiGETSHNSCLVMTSRepPQDLNILEGEALPVRCFPLKG 279
Cdd:pfam05729 79 PE-----RLLLILDGLDELVSDLGQLDGPCPVLTLLSSLLR--KKLLPGASLLLTVR--PDALRDLRRGLEEPRYLEVRG 149
|
170
....*....|..
gi 495460697 280 LPETHGQEIFKE 291
Cdd:pfam05729 150 FSESDRKQYVRK 161
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
568-722 |
8.59e-06 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 49.89 E-value: 8.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 568 GNMLSAAFSP-DGRMLAICDTDFQIRLWHVQTGKL-------LVICEGHTNWVRSVAFSRDGK-TLASGSADHTVKLWQV 638
Cdd:PTZ00421 76 GPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDV 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 639 SDGSCLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDTGQCLNRFTGHTG--------CVRSVAFSTDGktlAS 710
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclwAKRKDLIITLG---CS 232
|
170
....*....|..
gi 495460697 711 GSDDHTVILWDA 722
Cdd:PTZ00421 233 KSQQRQIMLWDT 244
|
|
| PQQ_ABC_repeats |
TIGR03866 |
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ... |
825-1039 |
9.12e-06 |
|
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.
Pssm-ID: 274824 [Multi-domain] Cd Length: 310 Bit Score: 48.88 E-value: 9.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 825 VAFSPEGNTL-VCVSLDQTVRLWDWGTGQCLKTWQGHTDwvfP--VAFSPDGKTL-ASGSNDNTVRLWDYHSDRCIS-IL 899
Cdd:TIGR03866 46 ITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLPSGPD---PeqFALHPNGKILyIANEDDALVTVIDIETRKVLAqID 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 900 HGHTAHvcSVAFSTDGKTVASSSRDETIRLW-DIKTGKCL-RILHGHTDwiYSVTFSGDGKTL-ASGSADQTVRLWDQRT 976
Cdd:TIGR03866 123 VGVEPE--GMAVSPDGKIVVNTSETTNMAHWiDTATYEIVdNTLVDARP--RFAEFTADGKELwVSSEIGGTVTVIDVAT 198
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495460697 977 GDCVSTLE----G-HTNQIWSV--AFSSDGKT----LASSNtdqTVRLWDVSTGECLKTLQgHGNRVKSVAFSP 1039
Cdd:TIGR03866 199 RKVIKKITfaipGvHPEKVQPVgiKLTKDGKTafvaLGPAN---RVAVVDAKTYEVLDYLL-VGQRVWQLAFTP 268
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
748-933 |
1.06e-05 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 49.51 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 748 NTLASgsNDHTVRL-WDARTGSCVSTHT-------------GHSSGVYSVAFST-DGKTLATGSGDHTVRLWDYHT-GIC 811
Cdd:PTZ00421 34 NTIAC--NDRFIAVpWQQLGSTAVLKHTdygklasnppillGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeGLT 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 812 LKT------LHGHTNQIFSVAFSPEG-NTLVCVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNT 884
Cdd:PTZ00421 112 QNIsdpivhLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495460697 885 VRLWDYHSDRCisilhghtahVCSVAFSTDGKTV---------------ASSSRDETIRLWDIK 933
Cdd:PTZ00421 192 LNIIDPRDGTI----------VSSVEAHASAKSQrclwakrkdliitlgCSKSQQRQIMLWDTR 245
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
655-889 |
2.22e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 655 FSVAFNPQGNTLISGSSDHTVILWDGDTGQcLNRFTGHTGC-VRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRT-CT 732
Cdd:COG4257 20 RDVAVDPDGAVWFTDQGGGRIGRLDPATGE-FTEYPLGGGSgPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGEITTFaLP 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 733 GHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGScVSTHTG--HSSGVYSVAFSTDGKTLATGSGDHTVRLWDYHTGi 810
Cdd:COG4257 99 GGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGE-VTEFPLptGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTG- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 811 clktlhghtnQIFSVAFSPEGNTLVCVSLDQTVRLW--DWGTGQCLK---------TWQGHTDWVFP--VAFSPDGKTLA 877
Cdd:COG4257 177 ----------TLTEYALPTPGAGPRGLAVDPDGNLWvaDTGSGRIGRfdpktgtvtEYPLPGGGARPygVAVDGDGRVWF 246
|
250
....*....|..
gi 495460697 878 SGSNDNTVRLWD 889
Cdd:COG4257 247 AESGANRIVRFD 258
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
963-1087 |
3.28e-05 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 45.43 E-value: 3.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 963 GSADqtVRLWDQRTGDcVSTLEGHTNQIWSVAFSSDGKTLA-SSNTDQTVRLW--DVSTGEcLKTLQGHGNRVKSVAFSP 1039
Cdd:COG0823 9 GNSD--IYVVDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGE-PRRLTFGGGYNASPSWSP 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 495460697 1040 KDNILASCSTDET---IRLWDLSTGECSKLLRGHNnwvfSVAFSPDGNTIA 1087
Cdd:COG0823 85 DGKRLAFVSRSDGrfdIYVLDLDGGAPRRLTDGPG----SPSWSPDGRRIV 131
|
|
| COG1672 |
COG1672 |
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only]; |
108-213 |
4.83e-05 |
|
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
Pssm-ID: 441278 [Multi-domain] Cd Length: 324 Bit Score: 46.83 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 108 FYGRMQELNTLQEWILQDNCCLVALLGMGGIGKTTLavkLAHLLQDK--FEFVMwRSLRNAPPLEEVLADMIQFLSVQQE 185
Cdd:COG1672 2 FFDREEELEELEKLYESDGGELVVVYGRRRVGKTSL---IKEFLKEKpaIYFDA-REESERESLRDFSEALAEALGDPLS 77
|
90 100
....*....|....*....|....*....
gi 495460697 186 TNLPSSVDgKILRLI-QYLQTARCLLVLD 213
Cdd:COG1672 78 KKEFESWE-EAFEYLaELAEGKRLVIVID 105
|
|
| PQQ_ABC_repeats |
TIGR03866 |
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ... |
999-1144 |
6.86e-05 |
|
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.
Pssm-ID: 274824 [Multi-domain] Cd Length: 310 Bit Score: 46.19 E-value: 6.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 999 GKTLASSNTDQTVRLWDVSTGECLKTLQGhGNRVKSVAFSPKDNILASC-STDETIRLWDLSTGECSKLLR-GHNNWVFs 1076
Cdd:TIGR03866 11 ETAYVSNEKDNTISVIDTATLKVTRTFPV-GQRPRGITFSKDGKLLYVCaSDSDTIQVIDPATGEVLHTLPsGPDPEQF- 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495460697 1077 vAFSPDGNTI-ASGSHDQTVKVWDVSTGEcrhtctghthLISSV---------AFSGDGQIVASGSQDQTVRLW-DTKT 1144
Cdd:TIGR03866 89 -ALHPNGKILyIANEDDALVTVIDIETRK----------VLAQIdvgvepegmAVSPDGKIVVNTSETTNMAHWiDTAT 156
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
673-838 |
9.31e-05 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 46.96 E-value: 9.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 673 HTVILWDGDTgqclNRFTGHTGC-VRSVAFSTDGKTLA-----SGSDDhtviLW--DASTGSWVRTCT-GHTSGVRSVAF 743
Cdd:COG4946 325 FTVPAEKGPT----RNLTNTPGVrERLPAWSPDGKSIAyfsdaSGEYE----LYiaPADGSGEPKQLTlGDLGRVFNPVW 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 744 STDGNTLASGSNDHTVRLWDARTGSCVS-THTGHSSGVYSVAFSTDGKTLA----TGSGDHTVRLWDYHTGiclKTLhgh 818
Cdd:COG4946 397 SPDGKKIAFTDNRGRLWVVDLASGKVRKvDTDGYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETG---KTV--- 470
|
170 180
....*....|....*....|....*..
gi 495460697 819 tnQI-------FSVAFSPEGNTLVCVS 838
Cdd:COG4946 471 --QLtdgryddGSPAFSPDGKYLYFLS 495
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
733-847 |
9.37e-05 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 46.42 E-value: 9.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 733 GHTSGVRSVAFST-DGNTLASGSNDHTVRLWDART---GSCVSTH----TGHSSGVYSVAFSTDGK-TLATGSGDHTVRL 803
Cdd:PTZ00421 73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeglTQNISDPivhlQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 495460697 804 WDYHTGICLKTLHGHTNQIFSVAFSPEGNTLVCVSLDQTVRLWD 847
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
669-793 |
1.34e-04 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 43.51 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 669 GSSDhtVILWDGDTGQcLNRFTGHTGCVRSVAFSTDGKTLASGSDDHT---VILWDASTGSwVRTCTGHTSGVRSVAFST 745
Cdd:COG0823 9 GNSD--IYVVDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGgpqIYVVDADGGE-PRRLTFGGGYNASPSWSP 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 495460697 746 DGNTLA-SGSNDHTVRLW--DARTGscvsTHTGHSSGVYSVAFSTDGKTLA 793
Cdd:COG0823 85 DGKRLAfVSRSDGRFDIYvlDLDGG----APRRLTDGPGSPSWSPDGRRIV 131
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
615-761 |
1.70e-04 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 44.85 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 615 VAFSRDGKTLASGSADHTVKLWQvSDGSCLQTC------TGHTDEVFSVAFNPQGNTLISGSSDHTVILWDGDtGQcLNR 688
Cdd:cd14954 123 VAVDSEGRIYVSDTRNHRVQVFD-SDGQFIRKFgfegagPGQLDSPRGVAVNPDGNIVVSDFNNHRLQVFDPD-GQ-FLR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 689 FTGHTG-------CVRSVAFSTDGKTLASGSDDHTVILWD------ASTGSWVRTcTGHTSGVRSVAFSTDGNTLASGSN 755
Cdd:cd14954 200 FFGSEGsgngqfkRPRGVAVDDEGNIIVADSGNHRVQVFSpdgeflCSFGTEGNG-EGQFDRPSGVAVTPDGRIVVVDRG 278
|
....*.
gi 495460697 756 DHTVRL 761
Cdd:cd14954 279 NHRIQV 284
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
1025-1100 |
2.34e-04 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 45.33 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1025 LQGHGNRVKSVAFSP-KDNILASCSTDETIRLW-----DLSTGECSK---LLRGHNNWVFSVAFSPDGNTI-ASGSHDQT 1094
Cdd:PTZ00420 70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphnDESVKEIKDpqcILKGHKKKISIIDWNPMNYYImCSSGFDSF 149
|
....*.
gi 495460697 1095 VKVWDV 1100
Cdd:PTZ00420 150 VNIWDI 155
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
969-1058 |
2.54e-04 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 45.33 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 969 VRLWDQRTGDCVSTLEGHTNQIWSVAFSS-DGKTLASSNTDQTVRLW-----DVSTGE-----CLktLQGHGNRVKSVAF 1037
Cdd:PTZ00420 56 IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphnDESVKEikdpqCI--LKGHKKKISIIDW 133
|
90 100
....*....|....*....|..
gi 495460697 1038 SPKDN-ILASCSTDETIRLWDL 1058
Cdd:PTZ00420 134 NPMNYyIMCSSGFDSFVNIWDI 155
|
|
| FxSxx_TPR |
NF040586 |
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ... |
102-216 |
2.83e-04 |
|
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.
Pssm-ID: 468560 [Multi-domain] Cd Length: 836 Bit Score: 45.29 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 102 APEPRSFYGRMQELNTLQEWILQDN--CCLVALLGMGGIGKTTLAVKLAHLLQDKFEFVMWRSLRNAPPLEEVLADMIQF 179
Cdd:NF040586 2 PPRNPNFTGREELLERLRDQLRSGGaaVVPQALHGLGGVGKTQLALEYAHRFRADYDLVWWIPADQPELVRASLAELARR 81
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 495460697 180 LSVQQEtnlPSSVDGKILRLIQYLQ----TARCLLVLDNTE 216
Cdd:NF040586 82 LGLPLG---PDDVDEAARAVLDALRrgepYRRWLLVFDNAD 119
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
557-684 |
3.23e-04 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 42.35 E-value: 3.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 557 DLAGSVF---TETLGNMLSAAFSPDGRMLAIC---DTDFQIRLWHVQTGKLLVICEGHtNWVRSVAFSRDGKTLA-SGSA 629
Cdd:COG0823 17 DLDGGEPrrlTNSPGIDTSPAWSPDGRRIAFTsdrGGGPQIYVVDADGGEPRRLTFGG-GYNASPSWSPDGKRLAfVSRS 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495460697 630 DHTVKLWQVS-DGSCLQTctgHTDEVFSVAFNPQGNTLI-----SGSSDHTVILWDGDTGQ 684
Cdd:COG0823 96 DGRFDIYVLDlDGGAPRR---LTDGPGSPSWSPDGRRIVfssdrGGRPDLYVVDLDGRKRR 153
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
868-961 |
4.41e-04 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 41.97 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 868 AFSPDGKTLASGSNDN-TVRLWDYHSD----RCISILHGHTAhvcSVAFSTDGKTVASSSRDET---IRLWDIKTGKCLR 939
Cdd:COG0823 37 AWSPDGRRIAFTSDRGgGPQIYVVDADggepRRLTFGGGYNA---SPSWSPDGKRLAFVSRSDGrfdIYVLDLDGGAPRR 113
|
90 100
....*....|....*....|..
gi 495460697 940 IlhghTDWIYSVTFSGDGKTLA 961
Cdd:COG0823 114 L----TDGPGSPSWSPDGRRIV 131
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
608-737 |
4.55e-04 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 43.91 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 608 HTNWVRSVAFSRDGKTLASGSADHTVKLWQVSDGSCLQTCTGHTDEVFsvafnPQGNTLISGSSDHtvILwdgdtgqCln 687
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSRNTQTEF-----PRKDHVIAETPFH--IL-------C-- 186
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 495460697 688 rftGHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTgHTSG 737
Cdd:pfam20426 187 ---GHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIR-HPSG 232
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
821-983 |
5.05e-04 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 43.91 E-value: 5.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 821 QIFSVAFSPEGNTLV-CVSLDQTVRLWDWGTGQCLKTWQGHTDWVFPVAFSPDGKTLASGSNDNTVRLWDyhsdrcisIL 899
Cdd:pfam20426 83 QCFATLQTPSENFLIsCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWE--------VL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 900 HGHTAHVCSVAFSTDgktvaSSSRDETIrlwdikTGKCLRILHGHTDWIYSVTFSGDGKTLASGSADQTVRLWDQRTGDC 979
Cdd:pfam20426 155 RGRSSEKRSRNTQTE-----FPRKDHVI------AETPFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRY 223
|
....
gi 495460697 980 VSTL 983
Cdd:pfam20426 224 VRSI 227
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
606-836 |
5.53e-04 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 43.31 E-value: 5.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 606 EGHTNWVRSVAFSRDGKTLASGSADHTVklwQV--SDGS------CLQTCTGHTDEVFSVAFNPQGNTLISGSSDHTVIL 677
Cdd:cd14954 20 DGELCRPWGVAVDKDGRIIVADRSNNRV---QVfdPDGKflrkfgSYGSRDGQFDRPAGVAVNSRGRIIVADKDNHRIQV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 678 WDGDtGQCLNRFTGH-TGCVR-----SVAFSTDGKTLASGSDDHTVILWDaSTGSWVRTC--TGHTSG----VRSVAFST 745
Cdd:cd14954 97 FDLN-GRFLLKFGERgTKNGQfnypwGVAVDSEGRIYVSDTRNHRVQVFD-SDGQFIRKFgfEGAGPGqldsPRGVAVNP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 746 DGNTLASGSNDHTVRLWDART------GSCvSTHTGHSSGVYSVAFSTDGKTLATGSGDHTVRLWDYH-TGICLKTLHGH 818
Cdd:cd14954 175 DGNIVVSDFNNHRLQVFDPDGqflrffGSE-GSGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPDgEFLCSFGTEGN 253
|
250 260
....*....|....*....|..
gi 495460697 819 TNQIFS----VAFSPEGNTLVC 836
Cdd:cd14954 254 GEGQFDrpsgVAVTPDGRIVVV 275
|
|
| Pgl |
COG2706 |
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism]; |
572-767 |
6.84e-04 |
|
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
Pssm-ID: 442025 [Multi-domain] Cd Length: 352 Bit Score: 43.36 E-value: 6.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 572 SAAFSPDGRMLAICD--TDfQIRLWHV--QTGKLlviceGHTNWV--------RSVAFSRDGKTL-ASGSADHTVKLWQV 638
Cdd:COG2706 154 SVVFDPDGRFLYVPDlgTD-RIYVYRLdpATGKL-----PEPPEVslppgsgpRHLAFHPNGRFAyVINELDSTVSVYAY 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 639 SDGsclqtcTGHTDEVFSVAFNPQGNTLISGSSDhtvilwdgdtgqclnrftghtgcvrsVAFSTDGKTL-AS--GSDDH 715
Cdd:COG2706 228 DAA------TGTLTLIQTVSTLPEDFTGENWAAD--------------------------IHISPDGRFLyVSnrGHNSI 275
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 495460697 716 TVILWDASTGSWVRTCTGHTSGV--RSVAFSTDGNTL-ASGSNDHTVRLW--DARTG 767
Cdd:COG2706 276 AVFAIDADGGKLTLVGHVPTGGKwpRDFAIDPDGRFLlVANQKSDNITVFriDADTG 332
|
|
| Peptidase_S9_N |
pfam02897 |
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ... |
691-938 |
7.20e-04 |
|
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.
Pssm-ID: 397164 [Multi-domain] Cd Length: 414 Bit Score: 43.45 E-value: 7.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 691 GHTGC-VRSVAFSTDGKTLA-----SGSDDHTVILWDASTGSWVrtctghTSGVRSVAFST-----DGNTL--------- 750
Cdd:pfam02897 120 DGTFTaLGGFAFSPDGRLLAyslslSGSDWYTIRFRDVETGEDL------PDVLEGVKFSGivwapDGKGFfytrydkpd 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 751 ---ASGSNDHTvRLWDARTGS------CVSTHTGHSSGVYSVAFSTDGKTLATGSGDHTvrlwdyhtgiclktlhgHTNQ 821
Cdd:pfam02897 194 ersDTGTNLNQ-KVWRHRLGTpqsqdvLVFEFPKDPLWSLGAERSEDGKYLFISSASGT-----------------DTNE 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 822 IFSV-AFSPEGNTLVCVS--LDQTVRLWDWGTGqclkTWQGHTDWVFpvafsPDGKTLASGSNDNTVRLWD----YHSDR 894
Cdd:pfam02897 256 LYYLdLTKETGDTLKLVDgrFDGEYDVEHNEGD----RFYFLTNDGA-----PNFRLVRVDLNDPSPSEWKdlvpEREDV 326
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 495460697 895 CISILHghtahvcsvafSTDGKTVASSSRD--ETIRLWDIKTGKCL 938
Cdd:pfam02897 327 VLEEIT-----------VFGNYLVLSYRRDalSRLQVFDLKTGKVL 361
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
740-960 |
8.82e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.57 E-value: 8.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 740 SVAFSTDGNTLASGSNDHTVRLWDARTGScVSTHTGHSSGVYSVAFSTDGKTLATGSGdHTVRLWDYHTGIcLKTLHGHT 819
Cdd:COG3386 12 GPVWDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLVADHG-RGLVRFDPADGE-VTVLADEY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 820 NQIFS----VAFSPEGN-------------TLVCVSLDQTVRLWDwgtgqclktwqghTDWVFP--VAFSPDGKTL-ASG 879
Cdd:COG3386 89 GKPLNrpndGVVDPDGRlyftdmgeylptgALYRVDPDGSLRVLA-------------DGLTFPngIAFSPDGRTLyVAD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 880 SNDNTVRLWDYHSDRCISilHGHT-AHVCSVAFSTDGKTVAS----------SSRdetIRLWDiKTGKCLRILHGHTDWI 948
Cdd:COG3386 156 TGAGRIYRFDLDADGTLG--NRRVfADLPDGPGGPDGLAVDAdgnlwvalwgGGG---VVRFD-PDGELLGRIELPERRP 229
|
250
....*....|...
gi 495460697 949 YSVTFSG-DGKTL 960
Cdd:COG3386 230 TNVAFGGpDLRTL 242
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
741-883 |
1.18e-03 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 40.81 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 741 VAFSTDGNtlasGSNDhtVRLWDARTGScVSTHTGHSSGVYSVAFSTDGKTLA---TGSGDHTVRLWDYHTGIcLKTLHG 817
Cdd:COG0823 1 LAFTLSRD----GNSD--IYVVDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAftsDRGGGPQIYVVDADGGE-PRRLTF 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495460697 818 HTNQIFSVAFSPEGNTLVCVSL-DQTVRLW--DWGTGQclkTWQGHTDWVFPvAFSPDGKTLASGSNDN 883
Cdd:COG0823 73 GGGYNASPSWSPDGKRLAFVSRsDGRFDIYvlDLDGGA---PRRLTDGPGSP-SWSPDGRRIVFSSDRG 137
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
918-1062 |
1.21e-03 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 40.81 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 918 VASSSRDETIRLW--DIKTGKcLRILHGHTDWIYSVTFSGDGKTLA-----SGSADqtVRLWDQRTGDcVSTLEGHTNQI 990
Cdd:COG0823 2 AFTLSRDGNSDIYvvDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAftsdrGGGPQ--IYVVDADGGE-PRRLTFGGGYN 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495460697 991 WSVAFSSDGKTLA-SSNTDQTVRLW--DVSTGEcLKTLQghgNRVKSVAFSPKDNILASCST---DETIRLWDLSTGE 1062
Cdd:COG0823 78 ASPSWSPDGKRLAfVSRSDGRFDIYvlDLDGGA-PRRLT---DGPGSPSWSPDGRRIVFSSDrggRPDLYVVDLDGRK 151
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
727-786 |
1.81e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 38.80 E-value: 1.81e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 727 WVRTCTGHTSGVRSVAFSTDGNTLASGSNDHTVRLWDARTGSCVSTHTGHSSGVYSVAFS 786
Cdd:pfam12894 30 WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
|
|
| HolB |
COG0470 |
DNA polymerase III, delta prime subunit [Replication, recombination and repair]; |
131-354 |
2.06e-03 |
|
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
Pssm-ID: 440238 [Multi-domain] Cd Length: 289 Bit Score: 41.50 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 131 ALL--GMGGIGKTTLAVKLAHLLqdkfefvMWRSLRNAPPLEEVLADMIQ------FLSVQQETNLPS-SVDgKILRLIQ 201
Cdd:COG0470 20 ALLlhGPPGIGKTTLALALARDL-------LCENPEGGKACGQCHSRLMAagnhpdLLELNPEEKSDQiGID-QIRELGE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 202 YLQTA-----RCLLVLDNTESILESGSRTggyregyagygeLLRTIGETSHNSCLVMTSREpPQDLnilegeaLPV---R 273
Cdd:COG0470 92 FLSLTpleggRKVVIIDEADAMNEAAANA------------LLKTLEEPPKNTPFILIAND-PSRL-------LPTirsR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 274 C--FPLKGLPETHGQEIFKEKGHfigDDTQWMTLIERYAGNPLAlkmvacAVRDffdsniaqfLDFLKEGSFIFDDIRDL 351
Cdd:COG0470 152 CqvIRFRPPSEEEALAWLREEGV---DEDALEAILRLAGGDPRA------AINL---------LQALAGRKELLEDLAAL 213
|
...
gi 495460697 352 LDR 354
Cdd:COG0470 214 LSR 216
|
|
| YjbI |
COG1357 |
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown]; |
519-566 |
3.02e-03 |
|
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
Pssm-ID: 440968 [Multi-domain] Cd Length: 178 Bit Score: 39.92 E-value: 3.02e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 495460697 519 NLLSQLQIDLNGYDFYGLTVWQANLQGLKLHNVNFAGCDLAGSVFTET 566
Cdd:COG1357 85 NLANLSGANLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGA 132
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
691-744 |
3.48e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 38.03 E-value: 3.48e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 495460697 691 GHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTGSWVRTCTGHTSGVRSVAFS 744
Cdd:pfam12894 36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
|
|
| WDR74 |
cd22857 |
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ... |
738-852 |
3.49e-03 |
|
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.
Pssm-ID: 439303 [Multi-domain] Cd Length: 325 Bit Score: 41.06 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 738 VRSVAF-STDGNT-LASGSNDHTVRLWDARTGS-CVSTHTGHSSGVYSVAFSTDGKTL--ATGSGDhtVRLWDYHTGICL 812
Cdd:cd22857 181 VTDLTFlSKDDHRkIVTGTGYHQVRLYDTRAQRrPVVSVDFGETPIKAVAEDPDGHTVyvGDTSGD--LASIDLRTGKLL 258
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 495460697 813 KTLHGHTN-QIFSVAFSPEGNTLVCVSLDQTVRLWDWGTGQ 852
Cdd:cd22857 259 GCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTETRQ 299
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
567-664 |
3.89e-03 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 41.56 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 567 LGNMLSAAFSPDGRMLAICDTDFqiRLWHVQ--TGKL-LVICEGHTNWVRSVAFSRDGKTLA---SGSADHT-VKLWQVS 639
Cdd:COG4946 388 LGRVFNPVWSPDGKKIAFTDNRG--RLWVVDlaSGKVrKVDTDGYGDGISDLAWSPDSKWLAyskPGPNQLSqIFLYDVE 465
|
90 100
....*....|....*....|....*
gi 495460697 640 DGSCLQTCTGHTDEvFSVAFNPQGN 664
Cdd:COG4946 466 TGKTVQLTDGRYDD-GSPAFSPDGK 489
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
661-725 |
4.34e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 40.83 E-value: 4.34e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495460697 661 PQGNTLIS----GSSDHTVILWDGDTGQCLNRftgHTGCVRSVAFSTDGKTLASGSDDHTVILWDASTG 725
Cdd:pfam20426 91 PSENFLIScgnwENSFQVISLNDGRMVQSIRQ---HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRG 156
|
|
| Ge1_WD40 |
pfam16529 |
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ... |
868-942 |
4.65e-03 |
|
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.
Pssm-ID: 465162 [Multi-domain] Cd Length: 328 Bit Score: 40.52 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 868 AFSPDGKTLASGSNDNTVRLW-----DYHSDRCisiLHGHTAH----VCSVAFSTDGK----------TVASSSRDETIR 928
Cdd:pfam16529 193 AFSPDGTALATASLDGEVKFFqiylfDNRNPRC---LHEWKPHdgkpLSSLFFLDNHKkppevqfwrfAITGADNNSELK 269
|
90
....*....|....
gi 495460697 929 LWDIKTGKCLRILH 942
Cdd:pfam16529 270 LWSCESWTCLQTIR 283
|
|
| Ge1_WD40 |
pfam16529 |
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ... |
1078-1152 |
4.73e-03 |
|
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.
Pssm-ID: 465162 [Multi-domain] Cd Length: 328 Bit Score: 40.52 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 1078 AFSPDGNTIASGSHDQTVKVW-----DVSTGECRHTCTGHT-HLISSVAFSGD---------GQIVASGS-QDQTVRLWD 1141
Cdd:pfam16529 193 AFSPDGTALATASLDGEVKFFqiylfDNRNPRCLHEWKPHDgKPLSSLFFLDNhkkppevqfWRFAITGAdNNSELKLWS 272
|
90
....*....|.
gi 495460697 1142 TKTGKCLKILR 1152
Cdd:pfam16529 273 CESWTCLQTIR 283
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
674-889 |
5.18e-03 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 40.08 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 674 TVILWDGDTGQCLNRFTGHTGcvRSVAFSTDGKTLASGSDDHTVILWDASTGS--WVRTCTGHTSGVRSVA-----FSTD 746
Cdd:pfam13360 4 VVTALDAATGAELWRVDLETG--LGGGVAVDGGRLFVATGGGQLVALDAATGKllWRQTLSGEVLGAPLVAggrvfVVAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 747 GNTLASGSNDHTVRLWDARTGSCVSTHTGHSS----GVYSVAFSTDGKTLA----TGSgdhtvRLWDYHTGICLKTLHGH 818
Cdd:pfam13360 82 DGSLIALDAADGRRLWSYQRSGEPLALRSSGSpavvGDTVVAGFSSGKLVAldpaTGK-----VRWEAPLAAPRGTNELE 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495460697 819 -TNQIFSVAFSPEGNTLVcVSLDQTVRLWDWGTGQCLKTWQGHTdwvfPVAFSPDGKTLASGSNDNTVRLWD 889
Cdd:pfam13360 157 rLVDITGTPVVAGGRVFA-SAYQGRLVAFDAATGRRLWTREISG----PNGPILDGDLLYVVSDDGELYALD 223
|
|
| Nup160 |
pfam11715 |
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ... |
764-1024 |
7.21e-03 |
|
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.
Pssm-ID: 432020 [Multi-domain] Cd Length: 540 Bit Score: 40.52 E-value: 7.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 764 ARTGSCVSTHTGHSSG-VYSVAFSTDGKTLaTGSgDHTVRLWDYHTGICLKTlhGHTNQIFSVAFS-PEGNTLVCV-SLD 840
Cdd:pfam11715 35 VATGGSVYFRKSNKYPrFFLWRVLTDGRVL-ELV-DLSLKSSLANLTLRLDF--PSPILPSCVCFTdSEDGDVLIViVTT 110
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 841 QTVRLWDwgtgqclktwqghtdwvfpVAFSPDGKTLASGSNDNTVRlWDyHSDRCISIL---HGHTAHVCSVAF---STD 914
Cdd:pfam11715 111 ASVHLYS-------------------LRLRPDFFRLPDAIFGDLGD-WC-KSYVPSSFSgfsKPGRLVAVSPLEllvSLA 169
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 915 GKTVASSSRDETIRLWdikTGKCLRilhgHTDWIYSVTFsgdgktLASGSADQTVRLwdqrtGDCVSTLEGHTNQiwSVA 994
Cdd:pfam11715 170 DGGLLKLTRSSDGGAW---KESTFE----PASWLQSLSG------LLGWLADPTIRY-----SGSSVALSLSAAP--AVT 229
|
250 260 270
....*....|....*....|....*....|
gi 495460697 995 FSSDGKTLASSNTDQTVRLWDVSTGECLKT 1024
Cdd:pfam11715 230 TVGGQNFLFTLSLDHTLRVWDLLTGKCLAT 259
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|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
130-259 |
7.48e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.51 E-value: 7.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495460697 130 VALLGMGGIGKTTLAVKLAHLLQDKFEFVMwrsLRNAPPLEEVLADMIQFLSVQQETNLPSSVDGKILRLIQYLQTARCL 209
Cdd:smart00382 5 ILIVGPPGSGKTTLARALARELGPPGGGVI---YIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 495460697 210 LVLDNTESILESGSRtggyREGYAGYGELLRTIGETSHNSCLVMTSREPP 259
Cdd:smart00382 82 LILDEITSLLDAEQE----ALLLLLEELRLLLLLKSEKNLTVILTTNDEK 127
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