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Conserved domains on  [gi|495692682|ref|WP_008417261|]
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Single-stranded DNA binding protein [Halalkalicoccus jeotgali]

Protein Classification

PRK07218 family protein( domain architecture ID 11482639)

PRK07218 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07218 PRK07218
Single-stranded DNA binding protein;
1-422 0e+00

Single-stranded DNA binding protein;


:

Pssm-ID: 180890 [Multi-domain]  Cd Length: 423  Bit Score: 689.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682   1 MSVDERAEALASDLGIDKEEVKQDLENLVSYSVPMDEAVQSLRRKYGGASTGSEPESKAIGEITTADSNVTVTARVLTAG 80
Cdd:PRK07218   2 MKLDPHAEELASDLGVDKEEVKEELENLVAYSVPIDEAKQSIRRKYGGGGSGGTPSSKDIKELSTDDKNVTVTGRVLTIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  81 KRSIRYQGNEQVITEGVLADSSGSIDYTAWEEFGLSPGDTVTAGNAGVREWDGHPELNLGESTSLAFEDETLDVPHEIGG 160
Cdd:PRK07218  82 ERSIRYQGDDHVIYEGILADETGTISYTAWKDFGLSPGDTVTIGNAGVREWDGRPELNIGESTTVSLLDDSSLPPYSIGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 161 ERDLVGVEPGDRGLTVEARILEVETRTIDGRDGETEILSGVLGDESARLPFTDWEPREEIREGADLRFENVYIREFRGAP 240
Cdd:PRK07218 162 DKKLIDLGPGDRGVNVEARVLELEHREIDGRDGETTILSGVLADETGRLPFTDWDPLPEIEIGASIRIEDAYVREFRGVP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 241 SVNCSEFTTVSALDREIAVSDSAPRKPIGEAVESGGAFDVELVGTIVAVRDGSGLIQRCPECGRMVQKGQCRSHGQVEGE 320
Cdd:PRK07218 242 SVNVSEFTTVEALDREVSVSKDPPRLKIREAVERGGIFDVELVGNIISVRDGSGLIERCPECGRVIQKGQCRSHGAVEGE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 321 DDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMDQEVVADSIRETLVGREYAVRGSLSIDEYGANLNAS 400
Cdd:PRK07218 322 DDLRIKAILDDGTGSVTVILDRELTEIVYGGTLEDAEELAREAMDKDVVAEDIRERLVGREYRVRGNLSVDEYGANLVAE 401

                        410       420
                 ....*....|....*....|..
gi 495692682 401 EFHEVTEPPAERATALLAEVSE 422
Cdd:PRK07218 402 SFWVPDDDPAKRAVALLAEVGP 423
 
Name Accession Description Interval E-value
PRK07218 PRK07218
Single-stranded DNA binding protein;
1-422 0e+00

Single-stranded DNA binding protein;


Pssm-ID: 180890 [Multi-domain]  Cd Length: 423  Bit Score: 689.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682   1 MSVDERAEALASDLGIDKEEVKQDLENLVSYSVPMDEAVQSLRRKYGGASTGSEPESKAIGEITTADSNVTVTARVLTAG 80
Cdd:PRK07218   2 MKLDPHAEELASDLGVDKEEVKEELENLVAYSVPIDEAKQSIRRKYGGGGSGGTPSSKDIKELSTDDKNVTVTGRVLTIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  81 KRSIRYQGNEQVITEGVLADSSGSIDYTAWEEFGLSPGDTVTAGNAGVREWDGHPELNLGESTSLAFEDETLDVPHEIGG 160
Cdd:PRK07218  82 ERSIRYQGDDHVIYEGILADETGTISYTAWKDFGLSPGDTVTIGNAGVREWDGRPELNIGESTTVSLLDDSSLPPYSIGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 161 ERDLVGVEPGDRGLTVEARILEVETRTIDGRDGETEILSGVLGDESARLPFTDWEPREEIREGADLRFENVYIREFRGAP 240
Cdd:PRK07218 162 DKKLIDLGPGDRGVNVEARVLELEHREIDGRDGETTILSGVLADETGRLPFTDWDPLPEIEIGASIRIEDAYVREFRGVP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 241 SVNCSEFTTVSALDREIAVSDSAPRKPIGEAVESGGAFDVELVGTIVAVRDGSGLIQRCPECGRMVQKGQCRSHGQVEGE 320
Cdd:PRK07218 242 SVNVSEFTTVEALDREVSVSKDPPRLKIREAVERGGIFDVELVGNIISVRDGSGLIERCPECGRVIQKGQCRSHGAVEGE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 321 DDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMDQEVVADSIRETLVGREYAVRGSLSIDEYGANLNAS 400
Cdd:PRK07218 322 DDLRIKAILDDGTGSVTVILDRELTEIVYGGTLEDAEELAREAMDKDVVAEDIRERLVGREYRVRGNLSVDEYGANLVAE 401

                        410       420
                 ....*....|....*....|..
gi 495692682 401 EFHEVTEPPAERATALLAEVSE 422
Cdd:PRK07218 402 SFWVPDDDPAKRAVALLAEVGP 423
RFA1 COG1599
ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];
161-422 2.06e-90

ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];


Pssm-ID: 441207 [Multi-domain]  Cd Length: 282  Bit Score: 275.01  E-value: 2.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 161 ERDLVGVEPGDRGLTVEARILEV-ETRTIDGRDG-ETEILSGVLGDESARLPFTDWEPRE--EIREGADLRFENVYIREF 236
Cdd:COG1599   21 EVKISDLSPGDRDVNVEGRVLEIgEERTFDRKDGsEGRVQSGVIGDETGRIRFTLWDDKAdlELEEGDVVRIENAYVREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 237 RGAPSVNCSEFTTVSALDREIAVSDSAPRKPIGEAVESGGafdVELVGTIVAVRDGSGLIQRCPECGRMVQK-GQCRSHG 315
Cdd:COG1599  101 NGGPELNLGERTTIEKLDEDVEVIPDEERTPIGDIEPGGT---VSVTGTIVSVRPGSGFIKRCPECNRVLQDdGQCREHG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 316 QVEGEDDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMDQEVVADSIRETLVGREYAVRGSLSiDEYGa 395
Cdd:COG1599  178 KVRGEYDLRIKAVLDDGTGTIRVVLWGELTEELYGIDLGDAIEIADDALDQGVVAEEIREKLLGRYYRVRGNLS-DRYG- 255

                        250       260
                 ....*....|....*....|....*..
gi 495692682 396 nLNASEFHEVTEPPAERATALLAEVSE 422
Cdd:COG1599  256 -LLADSIELSADDPAERAEELLAEVEG 281
SoSSB_OBF cd04491
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ...
 175-250 1.46e-13

SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.


Pssm-ID: 239937 [Multi-domain]  Cd Length: 82  Bit Score: 65.72  E-value: 1.46e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495692682 175 TVEARILEV-ETRTIDGRDGETEILSGVLGDESARLPFTDWEPR--EEIREGADLRFENVYIREFRGAPSVNCSEFTTV 250
Cdd:cd04491    1 SVEGKVLSIsEPREFTRDGSEGKVQSGLVGDETGTIRFTLWDEKaaDDLEPGDVVRIENAYVREFNGRLELSVGKNSEI 79
 
Name Accession Description Interval E-value
PRK07218 PRK07218
Single-stranded DNA binding protein;
1-422 0e+00

Single-stranded DNA binding protein;


Pssm-ID: 180890 [Multi-domain]  Cd Length: 423  Bit Score: 689.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682   1 MSVDERAEALASDLGIDKEEVKQDLENLVSYSVPMDEAVQSLRRKYGGASTGSEPESKAIGEITTADSNVTVTARVLTAG 80
Cdd:PRK07218   2 MKLDPHAEELASDLGVDKEEVKEELENLVAYSVPIDEAKQSIRRKYGGGGSGGTPSSKDIKELSTDDKNVTVTGRVLTIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  81 KRSIRYQGNEQVITEGVLADSSGSIDYTAWEEFGLSPGDTVTAGNAGVREWDGHPELNLGESTSLAFEDETLDVPHEIGG 160
Cdd:PRK07218  82 ERSIRYQGDDHVIYEGILADETGTISYTAWKDFGLSPGDTVTIGNAGVREWDGRPELNIGESTTVSLLDDSSLPPYSIGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 161 ERDLVGVEPGDRGLTVEARILEVETRTIDGRDGETEILSGVLGDESARLPFTDWEPREEIREGADLRFENVYIREFRGAP 240
Cdd:PRK07218 162 DKKLIDLGPGDRGVNVEARVLELEHREIDGRDGETTILSGVLADETGRLPFTDWDPLPEIEIGASIRIEDAYVREFRGVP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 241 SVNCSEFTTVSALDREIAVSDSAPRKPIGEAVESGGAFDVELVGTIVAVRDGSGLIQRCPECGRMVQKGQCRSHGQVEGE 320
Cdd:PRK07218 242 SVNVSEFTTVEALDREVSVSKDPPRLKIREAVERGGIFDVELVGNIISVRDGSGLIERCPECGRVIQKGQCRSHGAVEGE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 321 DDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMDQEVVADSIRETLVGREYAVRGSLSIDEYGANLNAS 400
Cdd:PRK07218 322 DDLRIKAILDDGTGSVTVILDRELTEIVYGGTLEDAEELAREAMDKDVVAEDIRERLVGREYRVRGNLSVDEYGANLVAE 401

                        410       420
                 ....*....|....*....|..
gi 495692682 401 EFHEVTEPPAERATALLAEVSE 422
Cdd:PRK07218 402 SFWVPDDDPAKRAVALLAEVGP 423
RFA1 COG1599
ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];
161-422 2.06e-90

ssDNA-binding replication factor A, large subunit [Replication, recombination and repair];


Pssm-ID: 441207 [Multi-domain]  Cd Length: 282  Bit Score: 275.01  E-value: 2.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 161 ERDLVGVEPGDRGLTVEARILEV-ETRTIDGRDG-ETEILSGVLGDESARLPFTDWEPRE--EIREGADLRFENVYIREF 236
Cdd:COG1599   21 EVKISDLSPGDRDVNVEGRVLEIgEERTFDRKDGsEGRVQSGVIGDETGRIRFTLWDDKAdlELEEGDVVRIENAYVREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 237 RGAPSVNCSEFTTVSALDREIAVSDSAPRKPIGEAVESGGafdVELVGTIVAVRDGSGLIQRCPECGRMVQK-GQCRSHG 315
Cdd:COG1599  101 NGGPELNLGERTTIEKLDEDVEVIPDEERTPIGDIEPGGT---VSVTGTIVSVRPGSGFIKRCPECNRVLQDdGQCREHG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 316 QVEGEDDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMDQEVVADSIRETLVGREYAVRGSLSiDEYGa 395
Cdd:COG1599  178 KVRGEYDLRIKAVLDDGTGTIRVVLWGELTEELYGIDLGDAIEIADDALDQGVVAEEIREKLLGRYYRVRGNLS-DRYG- 255

                        250       260
                 ....*....|....*....|....*..
gi 495692682 396 nLNASEFHEVTEPPAERATALLAEVSE 422
Cdd:COG1599  256 -LLADSIELSADDPAERAEELLAEVEG 281
PRK07217 PRK07217
replication factor A; Reviewed
 200-419 4.80e-48

replication factor A; Reviewed


Pssm-ID: 235970 [Multi-domain]  Cd Length: 311  Bit Score: 166.35  E-value: 4.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 200 GVLGDESARLPFTDWEPRE--EIREGADLRFENVYIREFRGAPSVNCSEFTTVSALDREIAVSDSAprkpigeavesgga 277
Cdd:PRK07217 106 GLLGDETGTIKFTKWAKSDlpELEEGKSYLLKNVVTDEYQGRFSVKLNRTTSIEELDEDIEVGDDE-------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 278 fdVELVGTIVAVRDGSGLIQRCPE--CGRMVQKGQCRSHGQVEGEDDLRVKAILDDGTGTVTAILGTELTREIYGGDIDD 355
Cdd:PRK07217 172 --VEVEGALVDIQSGSGLIKRCPEedCTRVLQNGRCSEHGKVEGEFDLRIKGVLDDGEEVQEVIFNREATEELTGITLEE 249

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495692682 356 AREQARDAMDQEVVADSIRETLVGREYAVRGSlsidEYGANLNASEFHEVTEPPAERATALLAE 419
Cdd:PRK07217 250 AKQMAMDALDTGVVLDELKEKLLGRYYRVTGP----TLGRYLLADSVEPLTGPVDAEELLIKAR 309
PRK06386 PRK06386
replication factor A; Reviewed
 60-406 6.01e-25

replication factor A; Reviewed


Pssm-ID: 235790 [Multi-domain]  Cd Length: 358  Bit Score: 104.99  E-value: 6.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  60 IGEITTADSNVTVTARVLTAGKRSIRYQGNEQVITEGVLADSSGSIDYTAWE-EFGLSPGDTVTAGNAGVREWDGHPELN 138
Cdd:PRK06386   5 ISDINAARQNVDLKVKVLSLNKRTIKNDRGETIYYYGIIGDETGTVPFTAWEfPDAVKSGDVIEIKYCYSKEYNGKIRIY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 139 LGESTSLAFE-DETLDV--PHEIGGERDLVGVEPgdrGLTVEARILEVETRTIDGRDGETEILSGVLGDESARLPFTDWE 215
Cdd:PRK06386  85 FDSRSEVMLKpDENIEVkrTYKLVKIRDLSLVTP---YVSVIGKITGITKKEYDSDGTSKIVYQGYIEDDTARVRISSFG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 216 prEEIREGADLRFENVYIREFRGAPSVNCSEFTTVSALDREIAVSD-----SAPRKPIGeavesggafDVELVGTIVAVR 290
Cdd:PRK06386 162 --KPLEDNRFVRIENARVSQYNGYIEISVGNKSVIKEVESDINLESrnifiFEIKSPVG---------GITIMGFIVSVG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 291 DGSGLIQRCPECGRMVQKGQCRSHGQVEGEDDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARdAMDQEVVa 370
Cdd:PRK06386 231 QGSRIFTKCSVCNKIIEDGVCKDHPDAPVYLDIFGYFTISDGTGFVTCYANKDSFLPYININENEFARKAS-SMNPNML- 308

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 495692682 371 dsIRETLVGREYAVRGSLSIDEYGANLNASEFHEVT 406
Cdd:PRK06386 309 --IKKNLLGKCFSVTGDLRKKDDEIDMNVISAKSIT 342
PRK12366 PRK12366
replication factor A; Reviewed
 70-392 8.30e-16

replication factor A; Reviewed


Pssm-ID: 237078 [Multi-domain]  Cd Length: 637  Bit Score: 79.32  E-value: 8.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  70 VTVTARVLT-AGKRSIRYQGNEQVITEGVLADSSGSIDYTAWEE-----FGLSPGDTVTAGNAGVREWDGHP-----ELN 138
Cdd:PRK12366 294 VDVKGRIIAiSDKREVERDDRTAEVQDIELADGTGRVRVSFWGEkakilENLKEGDAVKIENCKVRTYYDNEgekrvDLN 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 139 LGESTSLaFEDETLDVPH---EIGGERDLVGVEPGDRGLTVEARILEV-ETRTIDGRDGET-EILSGVLGDESARLPFTD 213
Cdd:PRK12366 374 AGYSSEI-IKDESISFEEieeKIYKIKDILNLEEDDNDITVIARVVEDyPVNEFERSDGSKgKVRNIELADGTGSIRLTL 452

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 214 WEPREE--IREGADLRFENVYIREFRGAPSVNCSEFTTVSALDREIAVSDsaPRKPIgEAVESGGAfdVELVGTIVAVRD 291
Cdd:PRK12366 453 WDDDAEieIKEGDAIKILHPYVKENGDYLDLSIGRYGRIEINPEGEIIKS--NRKFI-ADLEEDDT--VEIRGTVVDIRK 527

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 292 GSGLIQRCPECGRMVQ----KGQCRSHGQVEGEDDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMdqe 367
Cdd:PRK12366 528 QKIILYLCPNCRKRVEevdgEYICEFCGEVEPNELLMLNFTLDDGTGTINCRFYGKNVEKLLGMSKEELKELNLEAL--- 604

                        330       340
                 ....*....|....*....|....*
gi 495692682 368 vvadsirETLVGREYAVRGSLSIDE 392
Cdd:PRK12366 605 -------EDLLGEEVVFYGNVSFRN 622
SoSSB_OBF cd04491
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ...
 175-250 1.46e-13

SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.


Pssm-ID: 239937 [Multi-domain]  Cd Length: 82  Bit Score: 65.72  E-value: 1.46e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495692682 175 TVEARILEV-ETRTIDGRDGETEILSGVLGDESARLPFTDWEPR--EEIREGADLRFENVYIREFRGAPSVNCSEFTTV 250
Cdd:cd04491    1 SVEGKVLSIsEPREFTRDGSEGKVQSGLVGDETGTIRFTLWDEKaaDDLEPGDVVRIENAYVREFNGRLELSVGKNSEI 79
SoSSB_OBF cd04491
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ...
 71-145 4.93e-11

SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.


Pssm-ID: 239937 [Multi-domain]  Cd Length: 82  Bit Score: 58.40  E-value: 4.93e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495692682  71 TVTARVLTAG-KRSIRYQGNEQVITEGVLADSSGSIDYTAWEE---FGLSPGDTVTAGNAGVREWDGHPELNLGESTSL 145
Cdd:cd04491    1 SVEGKVLSISePREFTRDGSEGKVQSGLVGDETGTIRFTLWDEkaaDDLEPGDVVRIENAYVREFNGRLELSVGKNSEI 79
PRK06461 PRK06461
single-stranded DNA-binding protein; Reviewed
 53-157 1.50e-10

single-stranded DNA-binding protein; Reviewed


Pssm-ID: 180574 [Multi-domain]  Cd Length: 129  Bit Score: 58.51  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  53 SEPESKaIGEITTADSNVTVTARVLTAG-KRSIRYQGNEQVITEGVLADSSGSIDYTAWEEFG--LSPGDTVTAGNAGVR 129
Cdd:PRK06461   1 MEMITK-IKDLKPGMERVNVTVRVLEVGePKVIQTKGGPRTISEAVVGDETGRVKLTLWGEQAgsLKEGEVVEIENAWTT 79

                         90       100
                 ....*....|....*....|....*...
gi 495692682 130 EWDGHPELNLGESTSLAFEDETlDVPHE 157
Cdd:PRK06461  80 LYRGKVQLNVGKYGSISESDDE-EVPEA 106
PRK06461 PRK06461
single-stranded DNA-binding protein; Reviewed
 169-256 7.92e-09

single-stranded DNA-binding protein; Reviewed


Pssm-ID: 180574 [Multi-domain]  Cd Length: 129  Bit Score: 53.50  E-value: 7.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 169 PGDRGLTVEARILEV-ETRTIDGRDGETEILSGVLGDESARLPFTDW-EPREEIREGADLRFENVYIREFRGAPSVNCSE 246
Cdd:PRK06461  12 PGMERVNVTVRVLEVgEPKVIQTKGGPRTISEAVVGDETGRVKLTLWgEQAGSLKEGEVVEIENAWTTLYRGKVQLNVGK 91

                         90
                 ....*....|
gi 495692682 247 FTTVSALDRE 256
Cdd:PRK06461  92 YGSISESDDE 101
PRK08402 PRK08402
replication factor A; Reviewed
 163-405 5.61e-06

replication factor A; Reviewed


Pssm-ID: 169427 [Multi-domain]  Cd Length: 355  Bit Score: 48.26  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 163 DLVgvePGDRGLTVEARIL-EVETRTIDGRDGETEILSG-VLGDESARLPFTDWEPR-----EEIREGADLRFENVYIRE 235
Cdd:PRK08402  67 DLV---PGMRGVNIVGRVLrKYPPREYTKKDGSTGRVASlIIYDDTGRARVVLWDAKvakyyNKINVGDVIKVIDAQVRE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 236 -FRGAPSVNCSeFTTVSALDREIAVSDSAP-----------RKPIGEaVESGGAFdVELVGTI-----VAVRDGsgliqr 298
Cdd:PRK08402 144 sLSGLPELHIN-FRARIILNPDDPRVEEIPpleevrsynytRKKIGE-LEGGERF-VEVRGTIakvyrVLVYDA------ 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 299 CPECGRMVQKGQ------CRSHGQVEGEDDLRVKAILDDGTGTVTAILGTELTREIYGGDIDDAREQARDAMDQEV---- 368
Cdd:PRK08402 215 CPECRRKVDYDPatdtwiCPEHGEVEPIKITILDFGLDDGTGYIRVTLFGDDAAELLGVEPEEIAEKLKELIEMGLtpke 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 495692682 369 ----VADSIRETLVGREYAVRGSLSIDEY-GANLNASEFHEV 405
Cdd:PRK08402 295 aarkLAEEEFYNIIGREIVVRGNVIEDRFlGLILKASSWDEV 336
PRK14699 PRK14699
replication factor A; Provisional
 48-235 1.42e-05

replication factor A; Provisional


Pssm-ID: 173162 [Multi-domain]  Cd Length: 484  Bit Score: 47.30  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  48 GASTGSEPE------SKAIGEITTADSNVTVTARVLTAGK-RSI-RYQGNEQVITEGVLADSSGSIDYTAWEE-----FG 114
Cdd:PRK14699 151 GVLTESEEEidvaanSQKIKDIKDGMGDLNLTGKVLEISEiRTFqRKDGTSGKVGNLLLGDETGTLRVTLWDDktdflNQ 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 115 LSPGDTVTAGNAGVRE--WDGHPELNLGESTSLAFEDETLDVPHEIGGERDlvgVEPGDRGLTVEARILEV-ETRTIDGR 191
Cdd:PRK14699 231 IEYGDTVELINAYAREnaFTQKVELQVGNRSIIRKSEKKVEYEEEFTPIED---IKADMNNINISGRVLDIsEVRTFEKK 307

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 495692682 192 DGETEILSGV-LGDESARLPFTDWEPREEIREGAD----LRFENVYIRE 235
Cdd:PRK14699 308 DGSPGRVGNLlLGDSTGKIRLTLWDEKTNFLDEIDfdetVEVLNAYSRE 356
PRK07211 PRK07211
single-stranded DNA binding protein;
19-276 6.47e-05

single-stranded DNA binding protein;


Pssm-ID: 180887 [Multi-domain]  Cd Length: 485  Bit Score: 45.13  E-value: 6.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  19 EEVKQDLENLVSYSvPMDEAVQSLRRKYGG-----------ASTGSEPESKAIGEITTADSNVTVTARVLTAGK-RSIRY 86
Cdd:PRK07211   5 EDVYEDLDTDVSEE-EFREAVEEKVEQMGGladeetaamliAHELRDEEVNGIADIEPGMDEVKFLAKVLSIGDlRTFER 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  87 QGNE---QVITEGVlADSSGSIDYTAWEEFGLSPGDTVTAGNA---GVREWDGHPELNLGESTSLAFEDETLDVphEIGG 160
Cdd:PRK07211  84 DGEDedgRVINVEV-ADETGSVRVAFWDEQAVAAEEELEVGQVlriKGRPKDGYNGLEVSVDKVEPDPDAEIDV--QIGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 161 ERDLVGVEPGDRGLTVEARILEVET-RTIDGRDG-ETEILSGVLGDESARLPFTDWEPR----EEIREGADLRFENVYIR 234
Cdd:PRK07211 161 TYTVEDLSLGLSDVTLVGVVLDTDSvRTFDRDDGsEGRVSNLTVGDETGRVRVTLWDDRadlaEELDAGESVEIVDGYVR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 495692682 235 EFRGAPSVNCSEFTTVSALDREIA-VSDSAP--RKPIGEAVESGG 276
Cdd:PRK07211 241 ERDGSLELHVGDRGAVEEVDEDVEyVPDTTPieSLEIDETVDIAG 285
PRK15491 PRK15491
replication factor A; Provisional
 60-226 6.01e-04

replication factor A; Provisional


Pssm-ID: 185388 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  60 IGEITTADSNVTVTARVLT--AGKRSIRYQGNEQVITEGVLADSSGSIDYTAWEEFG--LSPGDTVTAGNAGVREW--DG 133
Cdd:PRK15491  60 IADINESSSNVNFTAKVVSifEPKEFNRNDGTTGRVGNIIVADETGSIRLTLWDDLAdlIKTGDIEVGKSLNISGYakEG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 134 HP--ELNLGESTSLAFEDETLDVPHEIGGERDlvgVEPGDRGLTVEARILEV-ETRTIDGRDGETEILSGVL-GDESARL 209
Cdd:PRK15491 140 YSgiEVNIGRYGGISESDENVKASINSQKISD---IKDGDSDINIVGKVLDIsDVRTFQKKDGSQGRVRNITiGDETGKI 216

                        170
                 ....*....|....*..
gi 495692682 210 PFTDWEPREEIREGADL 226
Cdd:PRK15491 217 RVTLWDGKTDLADKLEN 233
PRK14699 PRK14699
replication factor A; Provisional
 26-229 6.35e-04

replication factor A; Provisional


Pssm-ID: 173162 [Multi-domain]  Cd Length: 484  Bit Score: 41.91  E-value: 6.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  26 ENLVSYSVPMDEAVQSLRRKyGGASTGSEPESKAIGEITTADSNVTVTARVLTAGK-RSI-RYQGNEQVITEGVLADSSG 103
Cdd:PRK14699 246 ENAFTQKVELQVGNRSIIRK-SEKKVEYEEEFTPIEDIKADMNNINISGRVLDISEvRTFeKKDGSPGRVGNLLLGDSTG 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 104 SIDYTAWEEFG-----LSPGDTVTAGNAGVRE--WDGHPELNLGESTSLAFEDETLDVPHEIggeRDLVGVEPGDrGLTV 176
Cdd:PRK14699 325 KIRLTLWDEKTnfldeIDFDETVEVLNAYSREntFSQQVELNLGARGIIQKSEKKVEYREKF---TDIADIIPGE-SYSV 400

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495692682 177 EARILEV-ETRTIDGRDGETEILSGV-LGDESARLPFTDWEPREEIREGADLRFE 229
Cdd:PRK14699 401 QGKVSEIgELREFEREDGTENVVANLqLKDETGSIRLTLWGEQAYVIEDLDIDSE 455
PRK12366 PRK12366
replication factor A; Reviewed
 1-371 3.37e-03

replication factor A; Reviewed


Pssm-ID: 237078 [Multi-domain]  Cd Length: 637  Bit Score: 39.65  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682   1 MSVDERAEALASDlgIDKEEVKQDLENLVSYSVPM---DEAVQSLRRKYGGASTGS---EPESKAIGEITTADSNVTVTA 74
Cdd:PRK12366   3 MNIKKLKQKILEK--ISEEELEKKINEKIEENGGFlgeEAALMMVAQELGIDIEYGqeeEEEDFKISDIEEGQINVEITG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682  75 RVLTAGKRSI--RYQGNEQVITEGVLADSSGSIDYTAWEE-----FGLSPGDTVTAGNAGVREWDGHPELNLGESTSlaf 147
Cdd:PRK12366  81 RIIEISNIKTftRKDGSTGKLANITIADNTGTIRLTLWNDnakllKGLKEGDVIKIENARSRKWNNDVELNSGSETR--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 148 eDETLDVPHE-----IGGERDLVGVEPGDRGlTVEARILEV-ETRTIDGRDGETEIL-SGVLGDESARLPFTDW--EPRE 218
Cdd:PRK12366 158 -IDKLEKYDEsrypiIKENYDIPELEPNLSA-TIEGEVTKAyPIKEFTRKDGSEGKLkSFILKDDTGSIRVTLWndLTDI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 219 EIREGADLRFENvYIRE-FRGAPSVNCSEFTTVSALDREIAVSDsapRKPIGEAVESGGAFDVELVGTIVAVRDgsgliq 297
Cdd:PRK12366 236 EVNKGDIVRVKG-YVKQgYRTGLEISANNIEILEKLEKEEKELE---IVNIEELTEFEDGEEVDVKGRIIAISD------ 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495692682 298 rcpecGRMVQkgqcRSHGQVEGEDdlrvkAILDDGTGTVTAIL---GTELTREIYGGD---IDDAREQARDAMDQEVVAD 371
Cdd:PRK12366 306 -----KREVE----RDDRTAEVQD-----IELADGTGRVRVSFwgeKAKILENLKEGDavkIENCKVRTYYDNEGEKRVD 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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