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Conserved domains on  [gi|495707383|ref|WP_008431962|]
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MULTISPECIES: AraC family transcriptional regulator [unclassified Pseudomonas]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12117701)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain and an N-terminal arabinose binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 25-210 1.29e-39

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 138.16  E-value: 1.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383   25 GLDPQPLLLQYGLDPARLAEAGARLSIPRYMRLGFAAIQLTGDASLGLRMGQLSRLSQAGLAGVTAAQAPTVREAARTLT 104
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383  105 RFEALYgSNYRGQSSFHEDTDGAWLRFYSISPYNAYNRFVVDSIIAGWLHQLSSLSLQPVQAQRIEIEFEAPDYSERYSV 184
Cdd:pfam12625  81 RYLRLL-SDALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 495707383  185 LGDCPIQFGAEHNQLRLSQKTLALRN 210
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
255-337 2.09e-18

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 78.75  E-value: 2.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383   255 EPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTP 333
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 495707383   334 GEFR 337
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 25-210 1.29e-39

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 138.16  E-value: 1.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383   25 GLDPQPLLLQYGLDPARLAEAGARLSIPRYMRLGFAAIQLTGDASLGLRMGQLSRLSQAGLAGVTAAQAPTVREAARTLT 104
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383  105 RFEALYgSNYRGQSSFHEDTDGAWLRFYSISPYNAYNRFVVDSIIAGWLHQLSSLSLQPVQAQRIEIEFEAPDYSERYSV 184
Cdd:pfam12625  81 RYLRLL-SDALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 495707383  185 LGDCPIQFGAEHNQLRLSQKTLALRN 210
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
255-337 2.09e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 78.75  E-value: 2.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383   255 EPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTP 333
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 495707383   334 GEFR 337
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
120-344 9.05e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.05  E-value: 9.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 120 FHEDTDGAWLRFYSISPYNAYNRFVVDSIIAGWLHQLSSLSLQPVQAQRIEIEFEAPDYSERYSVLGDCPIQFGAEHNQL 199
Cdd:COG2207   33 ALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 200 RLSQKTLALRNPEHCPSTWQLLVQLCERELEQLTRTRSLRERITRLLGPMLNGGREPDLEEVASRLKLPTWTLRRKLAEE 279
Cdd:COG2207  113 LLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEE 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495707383 280 -GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQRHSA 344
Cdd:COG2207  193 tGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
261-339 1.59e-11

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 59.53  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383  261 VASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTY-IRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRR 338
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLlLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 495707383  339 S 339
Cdd:pfam12833  81 R 81
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 237-342 1.12e-10

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 61.55  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 237 SLRERITRLLGPmlNGGREPDLEEVASRLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFA 316
Cdd:PRK15185 206 TLKERVYNIISS--SPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYD 283

                         90       100
                 ....*....|....*....|....*.
gi 495707383 317 SAEAFQRAFKRWNSQTPGEFRRSQRH 342
Cdd:PRK15185 284 STSYFIQCFKKYFKTTPSTFIKMANH 309
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 230-344 1.91e-06

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 49.00  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 230 EQLTRTRSLRERITRLLGPML-NGGREPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFG 307
Cdd:COG4977  200 PLLVPLGHRDPRLARAQAWMEaNLEEPLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIE 279

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 495707383 308 EIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQRHSA 344
Cdd:COG4977  280 EIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 25-210 1.29e-39

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 138.16  E-value: 1.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383   25 GLDPQPLLLQYGLDPARLAEAGARLSIPRYMRLGFAAIQLTGDASLGLRMGQLSRLSQAGLAGVTAAQAPTVREAARTLT 104
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383  105 RFEALYgSNYRGQSSFHEDTDGAWLRFYSISPYNAYNRFVVDSIIAGWLHQLSSLSLQPVQAQRIEIEFEAPDYSERYSV 184
Cdd:pfam12625  81 RYLRLL-SDALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYER 159

                         170       180
                  ....*....|....*....|....*.
gi 495707383  185 LGDCPIQFGAEHNQLRLSQKTLALRN 210
Cdd:pfam12625 160 LFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
255-337 2.09e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 78.75  E-value: 2.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383   255 EPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTP 333
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 495707383   334 GEFR 337
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
120-344 9.05e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.05  E-value: 9.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 120 FHEDTDGAWLRFYSISPYNAYNRFVVDSIIAGWLHQLSSLSLQPVQAQRIEIEFEAPDYSERYSVLGDCPIQFGAEHNQL 199
Cdd:COG2207   33 ALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 200 RLSQKTLALRNPEHCPSTWQLLVQLCERELEQLTRTRSLRERITRLLGPMLNGGREPDLEEVASRLKLPTWTLRRKLAEE 279
Cdd:COG2207  113 LLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEE 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495707383 280 -GTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQRHSA 344
Cdd:COG2207  193 tGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
261-339 1.59e-11

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 59.53  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383  261 VASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTY-IRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRR 338
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLlLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 495707383  339 S 339
Cdd:pfam12833  81 R 81
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 237-342 1.12e-10

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 61.55  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 237 SLRERITRLLGPmlNGGREPDLEEVASRLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFA 316
Cdd:PRK15185 206 TLKERVYNIISS--SPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYD 283

                         90       100
                 ....*....|....*....|....*.
gi 495707383 317 SAEAFQRAFKRWNSQTPGEFRRSQRH 342
Cdd:PRK15185 284 STSYFIQCFKKYFKTTPSTFIKMANH 309
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 227-336 1.16e-08

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 55.46  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 227 RELEQltrtRSLRERITRLLgpMLNGGREPDLEEVASRLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAF 306
Cdd:PRK15186 175 RELSQ----NTLAENIYNII--ISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNI 248

                         90       100       110
                 ....*....|....*....|....*....|
gi 495707383 307 GEIAYLLGFASAEAFQRAFKRWNSQTPGEF 336
Cdd:PRK15186 249 TRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 230-344 1.91e-06

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 49.00  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 230 EQLTRTRSLRERITRLLGPML-NGGREPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIRDTELAFG 307
Cdd:COG4977  200 PLLVPLGHRDPRLARAQAWMEaNLEEPLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIE 279

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 495707383 308 EIAYLLGFASAEAFQRAFKRWNSQTPGEFRRSQRHSA 344
Cdd:COG4977  280 EIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 251-342 1.38e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 46.07  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 251 NGGREPDLEEVASRLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNS 330
Cdd:PRK09978 154 NIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYG 233

                         90
                 ....*....|...
gi 495707383 331 QTPGEFR-RSQRH 342
Cdd:PRK09978 234 MTPTEYQeRSAQG 246
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 260-342 2.96e-05

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 45.02  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 260 EVASRLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRS 339
Cdd:PRK15044 213 EVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITPLSFMRT 292


                 ...
gi 495707383 340 QRH 342
Cdd:PRK15044 293 MNH 295
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
257-339 4.44e-05

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 42.22  E-value: 4.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 257 DLEEVASRLKLPTWTLRRklaeegtQFRAILNDT--------RRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRW 328
Cdd:PRK10219  23 NIDVVAKKSGYSKWYLQR-------MFRTVTHQTlgdyirqrRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQ 95

                         90
                 ....*....|.
gi 495707383 329 NSQTPGEFRRS 339
Cdd:PRK10219  96 FDRTPSDYRHR 106
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 254-341 1.82e-04

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 42.73  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 254 REPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAMTYIrDTELAFGEIAYLLGFASAEAFQRAFKRWNSQT 332
Cdd:COG2169   99 DRPSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMT 177


                 ....*....
gi 495707383 333 PGEFRRSQR 341
Cdd:COG2169  178 PSAYRRGGA 186
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 198-341 2.86e-04

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 41.94  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 198 QLRLSQKTLALRNPEHCPS---TWQLLVQLCERELEQLTRTRSLRERITRLLGPML------NGGR-------------- 254
Cdd:PRK09685 130 YFPGQKPACAGRLSASLPMvqlSHRLLQQSMNGPALSETESEALLEALIALLRPALhqresvQPRRerqfqkvvalidqs 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 255 --EPDL--EEVASRLKLPTWTLRRKLAEEGTQF-RAILNdTRRDLAMTYIR----DTELAfgEIAYLLGFASAEAFQRAF 325
Cdd:PRK09685 210 iqEEILrpEWIAGELGISVRSLYRLFAEQGLVVaQYIRN-RRLDRCADDLRpaadDEKIT--SIAYKWGFSDSSHFSTAF 286

                        170
                 ....*....|....*.
gi 495707383 326 KRWNSQTPGEFRRSQR 341
Cdd:PRK09685 287 KQRFGVSPGEYRRKFR 302
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
219-337 5.12e-04

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 41.20  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 219 QLLVQLceRELEQLTRTRSLRERITRLLGPMLNG-GREPDLEEVASRLKLPTWTLRRKLAEE-GTQFRAILNDTRRDLAM 296
Cdd:PRK13503 152 QLLVLL--RKSSLQENGENSDARLNQLLAWLEDHfAEEVNWEALADQFSLSLRTLHRQLKQQtGLTPQRYLNRLRLLKAR 229

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 495707383 297 TYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFR 337
Cdd:PRK13503 230 HLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 258-341 2.94e-03

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 38.91  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495707383 258 LEEVASRLKLPTWTLRRKLAEEGTQFRAILNDTRRDLAMTYIRdTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFR 337
Cdd:PRK09940 153 LKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIR-VEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVS 231


                 ....
gi 495707383 338 RSQR 341
Cdd:PRK09940 232 KEYR 235
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 286-339 3.62e-03

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 38.58  E-value: 3.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495707383 286 ILNDTRRDLAMTYIRDTELAFGEIAYLLGFASAEAFQRAFKRWNSQTPGEFRRS 339
Cdd:PRK10296 220 IINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 301-338 3.95e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 34.82  E-value: 3.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 495707383  301 DTELAFGEIAYLLGFaSAEAFQRAFKRWNSQTPGEFRR 338
Cdd:pfam00165   6 STNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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