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Conserved domains on  [gi|495709184|ref|WP_008433763|]
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alpha/beta fold hydrolase [Pseudomonas sp. Ag1]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-313 2.26e-42

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 145.53  E-value: 2.26e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   4 TQQQKVKVNGIELNVHIAGPeSGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSAPPevADYDLLTLCA 83
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPA--GGYTLDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  84 DIKGAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSvpfagrsrrpviEIMRELYAdrfnyilYFQAPGVAE 163
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD------------EVLAALAE-------PLRRPGLAP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 164 KELDADIERTLRlfmqdqdvflqkkpasakllegvplpgtlpawcsqqdldvyvqtfandgfrgplnwyrnfernWQRTE 243
Cdd:COG0596  139 EALAALLRALAR---------------------------------------------------------------TDLRE 155

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 244 FLAGRQVlqPTLFLIGDRDPvgVFEAHTLKRMPDIVPNLQQSVLANCGHWIQNEQGPKVNELLLGFLGRT 313
Cdd:COG0596  156 RLARITV--PTLVIWGEKDP--IVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-313 2.26e-42

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 145.53  E-value: 2.26e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   4 TQQQKVKVNGIELNVHIAGPeSGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSAPPevADYDLLTLCA 83
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPA--GGYTLDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  84 DIKGAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSvpfagrsrrpviEIMRELYAdrfnyilYFQAPGVAE 163
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD------------EVLAALAE-------PLRRPGLAP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 164 KELDADIERTLRlfmqdqdvflqkkpasakllegvplpgtlpawcsqqdldvyvqtfandgfrgplnwyrnfernWQRTE 243
Cdd:COG0596  139 EALAALLRALAR---------------------------------------------------------------TDLRE 155

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 244 FLAGRQVlqPTLFLIGDRDPvgVFEAHTLKRMPDIVPNLQQSVLANCGHWIQNEQGPKVNELLLGFLGRT 313
Cdd:COG0596  156 RLARITV--PTLVIWGEKDP--IVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 27-295 4.98e-39

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 137.64  E-value: 4.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   27 PPVWLLHGFPECWHSWREQIPALVAQGYRVFVPEMRGYGQSSAPPEVADYDLLTLCADIKGAMDLFGHRRVVMIGHDWGA 106
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  107 VVAWHLALLEPERVSQLVTMSVPFAGRSRRPVIEIMRELYADRFNYILYFQAPGVAEkeldADIERTLRLFMQDQDVFLQ 186
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVADFAPNPLG----RLVAKLLALLLLRLRLLKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  187 KKPASAKLLEGVPLPGTLPAwcsqQDLDVYVQTFANDGFRGPLNWYRnfernwqrteflagrqvlQPTLFLIGDRDPvgV 266
Cdd:pfam00561 157 LPLLNKRFPSGDYALAKSLV----TGALLFIETWSTELRAKFLGRLD------------------EPTLIIWGDQDP--L 212

                         250       260
                  ....*....|....*....|....*....
gi 495709184  267 FEAHTLKRMPDIVPNLQQSVLANCGHWIQ 295
Cdd:pfam00561 213 VPPQALEKLAQLFPNARLVVIPDAGHFAF 241
PRK05855 PRK05855
SDR family oxidoreductase;
2-295 5.57e-22

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 96.20  E-value: 5.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   2 SETQQQKVKVNGIELNVHIAGPESGPPVWLLHGFPECWHSWREQIPALVAQgYRVFVPEMRGYGQSSAPPEVADYDLLTL 81
Cdd:PRK05855   1 SQPRRTVVSSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPKRTAAYTLARL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  82 CADIKGAMD-LFGHRRVVMIGHDWGAVVAWHlALLEPE---RVSQLVTMSVP---------FAGRSRRPVIEIMREL-YA 147
Cdd:PRK05855  80 ADDFAAVIDaVSPDRPVHLLAHDWGSIQGWE-AVTRPRaagRIASFTSVSGPsldhvgfwlRSGLRRPTPRRLARALgQL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 148 DRFNYILYFQAPGVAEKELDADIERTLrlfmqdqdvflqkkPASAKLLEGVPLPGTLPawcsqqdldvyvQTFANDGFRG 227
Cdd:PRK05855 159 LRSWYIYLFHLPVLPELLWRLGLGRAW--------------PRLLRRVEGTPVDPIPT------------QTTLSDGAHG 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495709184 228 pLNWYR-NFernwqRTEFLAGRQ--VLQPTLFLIGDRDP-VGvfeAHTLKRMPDIVPNLQQSVLAnCGHWIQ 295
Cdd:PRK05855 213 -VKLYRaNM-----IRSLSRPREryTDVPVQLIVPTGDPyVR---PALYDDLSRWVPRLWRREIK-AGHWLP 274
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-313 2.26e-42

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 145.53  E-value: 2.26e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   4 TQQQKVKVNGIELNVHIAGPeSGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSAPPevADYDLLTLCA 83
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPA--GGYTLDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  84 DIKGAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSvpfagrsrrpviEIMRELYAdrfnyilYFQAPGVAE 163
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD------------EVLAALAE-------PLRRPGLAP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 164 KELDADIERTLRlfmqdqdvflqkkpasakllegvplpgtlpawcsqqdldvyvqtfandgfrgplnwyrnfernWQRTE 243
Cdd:COG0596  139 EALAALLRALAR---------------------------------------------------------------TDLRE 155

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 244 FLAGRQVlqPTLFLIGDRDPvgVFEAHTLKRMPDIVPNLQQSVLANCGHWIQNEQGPKVNELLLGFLGRT 313
Cdd:COG0596  156 RLARITV--PTLVIWGEKDP--IVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 27-295 4.98e-39

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 137.64  E-value: 4.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   27 PPVWLLHGFPECWHSWREQIPALVAQGYRVFVPEMRGYGQSSAPPEVADYDLLTLCADIKGAMDLFGHRRVVMIGHDWGA 106
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  107 VVAWHLALLEPERVSQLVTMSVPFAGRSRRPVIEIMRELYADRFNYILYFQAPGVAEkeldADIERTLRLFMQDQDVFLQ 186
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVADFAPNPLG----RLVAKLLALLLLRLRLLKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  187 KKPASAKLLEGVPLPGTLPAwcsqQDLDVYVQTFANDGFRGPLNWYRnfernwqrteflagrqvlQPTLFLIGDRDPvgV 266
Cdd:pfam00561 157 LPLLNKRFPSGDYALAKSLV----TGALLFIETWSTELRAKFLGRLD------------------EPTLIIWGDQDP--L 212

                         250       260
                  ....*....|....*....|....*....
gi 495709184  267 FEAHTLKRMPDIVPNLQQSVLANCGHWIQ 295
Cdd:pfam00561 213 VPPQALEKLAQLFPNARLVVIPDAGHFAF 241
PRK05855 PRK05855
SDR family oxidoreductase;
2-295 5.57e-22

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 96.20  E-value: 5.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   2 SETQQQKVKVNGIELNVHIAGPESGPPVWLLHGFPECWHSWREQIPALVAQgYRVFVPEMRGYGQSSAPPEVADYDLLTL 81
Cdd:PRK05855   1 SQPRRTVVSSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPKRTAAYTLARL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  82 CADIKGAMD-LFGHRRVVMIGHDWGAVVAWHlALLEPE---RVSQLVTMSVP---------FAGRSRRPVIEIMREL-YA 147
Cdd:PRK05855  80 ADDFAAVIDaVSPDRPVHLLAHDWGSIQGWE-AVTRPRaagRIASFTSVSGPsldhvgfwlRSGLRRPTPRRLARALgQL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 148 DRFNYILYFQAPGVAEKELDADIERTLrlfmqdqdvflqkkPASAKLLEGVPLPGTLPawcsqqdldvyvQTFANDGFRG 227
Cdd:PRK05855 159 LRSWYIYLFHLPVLPELLWRLGLGRAW--------------PRLLRRVEGTPVDPIPT------------QTTLSDGAHG 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495709184 228 pLNWYR-NFernwqRTEFLAGRQ--VLQPTLFLIGDRDP-VGvfeAHTLKRMPDIVPNLQQSVLAnCGHWIQ 295
Cdd:PRK05855 213 -VKLYRaNM-----IRSLSRPREryTDVPVQLIVPTGDPyVR---PALYDDLSRWVPRLWRREIK-AGHWLP 274
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-158 7.87e-19

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 83.13  E-value: 7.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   1 MSETQQQKVKVNGIELNVHIAGPESGP--PVWLLHGFPECWHSWREQIPALVAQGYRVFVPEMRGYGQSSAPPEVADyDL 78
Cdd:COG2267    1 MTRRLVTLPTRDGLRLRGRRWRPAGSPrgTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVD-SF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  79 LTLCADIKGAMDLF---GHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMS-----VPFAGRSRRPVIEIMRELYADRF 150
Cdd:COG2267   80 DDYVDDLRAALDALrarPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLApayraDPLLGPSARWLRALRLAEALARI 159


                 ....*....
gi 495709184 151 NY-ILYFQA 158
Cdd:COG2267  160 DVpVLVLHG 168
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 7-312 2.09e-16

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 78.83  E-value: 2.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   7 QKVKVNGIELNVHIAGPESGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSapPEVADYDLLTLCADIK 86
Cdd:PRK14875 112 RKARIGGRTVRYLRLGEGDGTPVVLIHGFGGDLNNWLFNHAAL-AAGRPVIALDLPGHGASS--KAVGAGSLDELAAAVL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  87 GAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMS---------VPF-----AGRSRRPVIEIMRELYADrfny 152
Cdd:PRK14875 189 AFLDALGIERAHLVGHSMGGAVALRLAARAPQRVASLTLIApaglgpeinGDYidgfvAAESRRELKPVLELLFAD---- 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 153 ilyfqaPGVAEKELDADIERTLRlfmqdqdvflqkkpasaklLEGVplpgtlpawcsQQDLDVYVQTFANDGFrgplnwy 232
Cdd:PRK14875 265 ------PALVTRQMVEDLLKYKR-------------------LDGV-----------DDALRALADALFAGGR------- 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 233 rnfernwQRTEFLAGRQVLQ-PTLFLIGDRDPVgVFEAHTLKrMPDIVpnlQQSVLANCGHWIQNEQGPKVNELLLGFLG 311
Cdd:PRK14875 302 -------QRVDLRDRLASLAiPVLVIWGEQDRI-IPAAHAQG-LPDGV---AVHVLPGAGHMPQMEAAADVNRLLAEFLG 369


                 .
gi 495709184 312 R 312
Cdd:PRK14875 370 K 370
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 13-126 5.93e-16

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 76.55  E-value: 5.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  13 GIELNVHI--AGPESGPPVWLLHGFPecwhSW----REQIPALVAQGYRVFVPEMRGYGQSSAPPEVADYDLLTLCADIK 86
Cdd:PRK00870  31 GGPLRMHYvdEGPADGPPVLLLHGEP----SWsylyRKMIPILAAAGHRVIAPDLIGFGRSDKPTRREDYTYARHVEWMR 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 495709184  87 GAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTM 126
Cdd:PRK00870 107 SWFEQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVA 146
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 1-234 3.18e-15

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 74.65  E-value: 3.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   1 MSETQQQKVKVNGIELNVHIAGpeSGPPVWLLHGFPECWHSWREQIPALVAQGyRVFVPEMRGYGQSSAPPEvaDYDLLT 80
Cdd:PRK03592   4 EPPGEMRRVEVLGSRMAYIETG--EGDPIVFLHGNPTSSYLWRNIIPHLAGLG-RCLAPDLIGMGASDKPDI--DYTFAD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  81 LCADIKGAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSvPFAgrsRRPVIEIMRELYADRFNyilYFQAPG 160
Cdd:PRK03592  79 HARYLDAWFDALGLDDVVLVGHDWGSALGFDWAARHPDRVRGIAFME-AIV---RPMTWDDFPPAVRELFQ---ALRSPG 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495709184 161 VAEKeldadiertlrlFMQDQDVFlqkkpasaklLEGVpLPGTLPAWCSQQDLDVYVQTFANDGFRGP-LNWYRN 234
Cdd:PRK03592 152 EGEE------------MVLEENVF----------IERV-LPGSILRPLSDEEMAVYRRPFPTPESRRPtLSWPRE 203
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
12-148 9.47e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 63.50  E-value: 9.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  12 NGIELNVHIAGPESGPP---VWLLHGFPE-CWHSWREQIPALVAQGYRVFVPEMRGYGQSSAPPEVADYDlltlcaDIKG 87
Cdd:COG1506    6 DGTTLPGWLYLPADGKKypvVVYVHGGPGsRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVD------DVLA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495709184  88 AMD------LFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSVPFAGRSRRPVIEIMRELYAD 148
Cdd:COG1506   80 AIDylaarpYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERLMG 146
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 28-130 4.53e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 55.99  E-value: 4.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  28 PVWLLHGFPECWHSWREQIPALVAQGYRVFVPEmrgYGQSSAPPEV-ADYdlltLCADIKGAMDLFGHRRVVMIGHDWGA 106
Cdd:COG1075    7 PVVLVHGLGGSAASWAPLAPRLRAAGYPVYALN---YPSTNGSIEDsAEQ----LAAFVDAVLAATGAEKVDLVGHSMGG 79

                         90       100
                 ....*....|....*....|....*.
gi 495709184 107 VVAWHLA--LLEPERVSQLVTMSVPF 130
Cdd:COG1075   80 LVARYYLkrLGGAAKVARVVTLGTPH 105
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 31-192 4.17e-09

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 55.56  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   31 LLHGFPECWhswrEQIPALVAQGYRVFVPEMRGYGQSSAPPEvaDYDLLTLCADIKGamDLFGHRRVVMIGHDWGAVVAW 110
Cdd:pfam12697   3 LVHGAGLSA----APLAALLAAGVAVLAPDLPGHGSSSPPPL--DLADLADLAALLD--ELGAARPVVLVGHSLGGAVAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  111 HLALLEPERVSQLVTMSVPFAGRSRR-PVIEIMRELYADRFNYILYFQAPGVAEKELDADIERTLRLFMQDQDVFLQKKP 189
Cdd:pfam12697  75 AAAAAALVVGVLVAPLAAPPGLLAALlALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALARLAALLAALALLP 154


                  ...
gi 495709184  190 ASA 192
Cdd:pfam12697 155 LAA 157
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 29-124 7.24e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 55.30  E-value: 7.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184   29 VWLLHGFpeCWHSWR--EQIPALVAQGYRVFVPEMRGYGQSsaPPE---VADYDllTLCADIKGAMDL----FGHRRVVM 99
Cdd:pfam12146   7 VVLVHGL--GEHSGRyaHLADALAAQGFAVYAYDHRGHGRS--DGKrghVPSFD--DYVDDLDTFVDKireeHPGLPLFL 80

                          90       100
                  ....*....|....*....|....*
gi 495709184  100 IGHDWGAVVAWHLALLEPERVSQLV 124
Cdd:pfam12146  81 LGHSMGGLIAALYALRYPDKVDGLI 105
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
12-133 1.56e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 54.20  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  12 NGIELNVHIAGPESGPP---VWLLHGfpecWHSWREQIPA----LVAQGYRVFVPEMRGYGQSSAPPEVADYDLLTLC-- 82
Cdd:COG0412   12 DGVTLPGYLARPAGGGPrpgVVVLHE----IFGLNPHIRDvarrLAAAGYVVLAPDLYGRGGPGDDPDEARALMGALDpe 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  83 ---ADIKGAMD-LFGH-----RRVVMIGHDWGAVVAWHLALLEPErvsqlVTMSVPFAGR 133
Cdd:COG0412   88 llaADLRAALDwLKAQpevdaGRVGVVGFCFGGGLALLAAARGPD-----LAAAVSFYGG 142
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 12-131 6.10e-08

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 52.61  E-value: 6.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  12 NGIEL--NVHIAGPESGPPVWLL--HGFPECWHSWREQIPALVAQGYRVFVPEMRGYGQSSAPP-EVADYDLLtlcaDIK 86
Cdd:COG1073   19 DGIKLagDLYLPAGASKKYPAVVvaHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPrEEGSPERR----DAR 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 495709184  87 GAMD-----LFGHR-RVVMIGHDWGAVVAWHLALLEPeRVSQLVTMSvPFA 131
Cdd:COG1073   95 AAVDylrtlPGVDPeRIGLLGISLGGGYALNAAATDP-RVKAVILDS-PFT 143
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
31-145 2.51e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 50.71  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  31 LLHGFPECWHSWREQIPALVAQGYRVFVPEMRGYGQSSAppevadyDLLTLC-----ADIKGAMDLF--GHRRVVMIGHD 103
Cdd:COG1647   20 LLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPE-------DLLKTTwedwlEDVEEAYEILkaGYDKVIVIGLS 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 495709184 104 WGAVVAWHLALLEPErVSQLVTMSVPFAGRSRR-PVIEIMREL 145
Cdd:COG1647   93 MGGLLALLLAARYPD-VAGLVLLSPALKIDDPSaPLLPLLKYL 134
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
48-125 1.52e-06

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 48.73  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  48 ALVAQGYRVFVPEMRGYGQSSAPP-EVADYDLLTL-CADIKGAMD----LFGHRRVVMIGHDWGAVVAwhLALLEPERVS 121
Cdd:COG4757   54 YLAERGFAVLTYDYRGIGLSRPGSlRGFDAGYRDWgELDLPAVLDalraRFPGLPLLLVGHSLGGQLL--GLAPNAERVD 131


                 ....
gi 495709184 122 QLVT 125
Cdd:COG4757  132 RLVT 135
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 21-312 5.13e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 47.04  E-value: 5.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  21 AGPeSGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQS------SAPP------EVADYDLLTLCADIKGA 88
Cdd:PLN02824  25 AGT-SGPALVLVHGFGGNADHWRKNTPVL-AKSHRVYAIDLLGYGYSdkpnprSAPPnsfytfETWGEQLNDFCSDVVGD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  89 mdlfghrRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSVPFAG-------RSRRPVIEIMRELYADRFNYILYFQApgV 161
Cdd:PLN02824 103 -------PAFVICNSVGGVVGLQAAVDAPELVRGVMLINISLRGlhikkqpWLGRPFIKAFQNLLRETAVGKAFFKS--V 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 162 AEKELDADIERtlrlfmqdqDVFLQKKPASAKLLEGVPLPGTLPAwcsqqDLDVYVQTFANDGfrGPLNwyrnfernwqr 241
Cdd:PLN02824 174 ATPETVKNILC---------QCYHDDSAVTDELVEAILRPGLEPG-----AVDVFLDFISYSG--GPLP----------- 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495709184 242 TEFLAgrQVLQPTLFLIGDRDPvgvFEAHTLKRMPDIVPNLQQSV-LANCGHWIQNEQGPKVNELLLGFLGR 312
Cdd:PLN02824 227 EELLP--AVKCPVLIAWGEKDP---WEPVELGRAYANFDAVEDFIvLPGVGHCPQDEAPELVNPLIESFVAR 293
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
31-205 5.23e-06

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 46.93  E-value: 5.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  31 LLHGF---PECWHSWREQIpalvAQGYRVFVPEMRGYGQSSAppevadYDLLTLcADIKGAMDLFGHRRVVMIGHDWGAV 107
Cdd:PRK10349  18 LLHGWglnAEVWRCIDEEL----SSHFTLHLVDLPGFGRSRG------FGALSL-ADMAEAVLQQAPDKAIWLGWSLGGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 108 VAWHLALLEPERVSQLVTM-SVP-FAGRSRRPVI--EIMrelyadrfnyilyfqapGVAEKELDADIERTLRLFMQDQDV 183
Cdd:PRK10349  87 VASQIALTHPERVQALVTVaSSPcFSARDEWPGIkpDVL-----------------AGFQQQLSDDFQRTVERFLALQTM 149

                        170       180
                 ....*....|....*....|..
gi 495709184 184 FLQKKPASAKLLEGVPLPGTLP 205
Cdd:PRK10349 150 GTETARQDARALKKTVLALPMP 171
PLN02578 PLN02578
hydrolase
 26-137 5.26e-06

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 47.53  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  26 GPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSAPpeVADYDLLTLCADIKGAMDLFGHRRVVMIGHDWG 105
Cdd:PLN02578  86 GLPIVLIHGFGASAFHWRYNIPEL-AKKYKVYALDLLGFGWSDKA--LIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLG 162

                         90       100       110
                 ....*....|....*....|....*....|....
gi 495709184 106 AVVAWHLALLEPERVSQLVTM--SVPFAGRSRRP 137
Cdd:PLN02578 163 GFTALSTAVGYPELVAGVALLnsAGQFGSESREK 196
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 25-310 2.36e-05

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 45.60  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  25 SGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSAPPEVAdYDLLTLCADIKGAMDLFGHRRVVMIGHDW 104
Cdd:PLN02679  87 SGPPVLLVHGFGASIPHWRRNIGVL-AKNYTVYAIDLLGFGASDKPPGFS-YTMETWAELILDFLEEVVQKPTVLIGNSV 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 105 GAvVAWHLALLEPER--VSQLVTMSVPfAGRSRRPVIEIMRELYADRFNYILYF--QAPGVAEKELDADIER-TLRLFMq 179
Cdd:PLN02679 165 GS-LACVIAASESTRdlVRGLVLLNCA-GGMNNKAVVDDWRIKLLLPLLWLIDFllKQRGIASALFNRVKQRdNLKNIL- 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184 180 dQDVFLQKKPASAKLLEGVPLPGtlpawCSQQDLDVYVQTFAndGFRGPlnwyrnfernwqrTEFLAGRQVLQPTLFLIG 259
Cdd:PLN02679 242 -LSVYGNKEAVDDELVEIIRGPA-----DDEGALDAFVSIVT--GPPGP-------------NPIKLIPRISLPILVLWG 300

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 495709184 260 DRD-------PVGVFeahtLKRMPDIVPNLQQSVLANCGHWIQNEQGPKVNELLLGFL 310
Cdd:PLN02679 301 DQDpftpldgPVGKY----FSSLPSQLPNVTLYVLEGVGHCPHDDRPDLVHEKLLPWL 354
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 18-124 7.26e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 43.69  E-value: 7.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  18 VHIAGPESGPPVWLLHGFPECWHSWREQIPALVAQgYRVFVPEMRGYGQSSAPPEVAdYDLLTLCADIKGAMDLFGHRRV 97
Cdd:PRK03204  26 IHYIDEGTGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPSGFG-YQIDEHARVIGEFVDHLGLDRY 103

                         90       100
                 ....*....|....*....|....*..
gi 495709184  98 VMIGHDWGAVVAWHLALLEPERVSQLV 124
Cdd:PRK03204 104 LSMGQDWGGPISMAVAVERADRVRGVV 130
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 18-124 3.66e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 41.82  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  18 VHIAGPESGPPVWLLHGFPECWHSWREQIPALVAQgYRVFVPEMRGYGQSSAPP------EVADYDLLTLCADIKGAMDL 91
Cdd:PLN02894  97 VTFDSKEDAPTLVMVHGYGASQGFFFRNFDALASR-FRVIAIDQLGWGGSSRPDftckstEETEAWFIDSFEEWRKAKNL 175

                         90       100       110
                 ....*....|....*....|....*....|...
gi 495709184  92 FGhrrVVMIGHDWGAVVAWHLALLEPERVSQLV 124
Cdd:PLN02894 176 SN---FILLGHSFGGYVAAKYALKHPEHVQHLI 205
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 21-70 6.32e-04

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 41.02  E-value: 6.32e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 495709184  21 AGPESGPPVWLLHGFPECWHSWREQIPALvAQGYRVFVPEMRGYGQSSAP 70
Cdd:PLN03084 122 SGSNNNPPVLLIHGFPSQAYSYRKVLPVL-SKNYHAIAFDWLGFGFSDKP 170
PRK10673 PRK10673
esterase;
52-136 2.47e-03

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 38.94  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495709184  52 QGYRVFVPEMRGYGQSSAPPEVaDYDllTLCADIKGAMDLFGHRRVVMIGHDWGAVVAWHLALLEPERVSQLVTMSV-PF 130
Cdd:PRK10673  41 NDHDIIQVDMRNHGLSPRDPVM-NYP--AMAQDLLDTLDALQIEKATFIGHSMGGKAVMALTALAPDRIDKLVAIDIaPV 117


                 ....*.
gi 495709184 131 AGRSRR 136
Cdd:PRK10673 118 DYHVRR 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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