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Conserved domains on  [gi|495774841|ref|WP_008499420|]
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MULTISPECIES: colanic acid biosynthesis glycosyltransferase WcaE [Enterobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
wcaE TIGR04009
colanic acid biosynthesis glycosyl transferase WcaE; This gene is one of the glycosyl ...
 1-248 0e+00

colanic acid biosynthesis glycosyl transferase WcaE; This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.


:

Pssm-ID: 188524  Cd Length: 248  Bit Score: 510.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841    1 MFLSVITVAFRNYEGVVKTWRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKLNGEFNLRYISEKDKGIYDAMNKGINM 80
Cdd:TIGR04009   1 MLLSVITVAFRNYEGVVKTWRSLRNLARDPSLSFEWIVVDGGSNDGTAEFLEKLNGEFNLRFVSEKDNGIYDAMNKGIAM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   81 AQGRYAIFLNSGDIFHDDVALFARQLARQKEDAMYIGDALLDFGDGHKVCRSAKPGWYIYHSLPASHQAIFFPVKGLKKQ 160
Cdd:TIGR04009  81 AQGRYTLFLNSGDIFHEDVADFVRQLARQKDNAMYIGDALLDFGDGNKIRRSAKPGWYIYHSLPASHQAIFFPTSGLKKY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  161 PYDLQYKVSSDYALAASLYKSGYPFRRIKGLVSEFSMGGVSTSNNLELCQDAKNVQRKILRVPGFWAELSYFLRVRTTSK 240
Cdd:TIGR04009 161 PYDLQYKVSSDYALAAKLYKSGYPFRRIKGLVSEFSMGGVSTSNNLELCQDAKKVQRNILRVPGFWAELSYLLRLKTTGK 240


                  ....*...
gi 495774841  241 TKALYNKA 248
Cdd:TIGR04009 241 TKALYNKA 248
 
Name Accession Description Interval E-value
wcaE TIGR04009
colanic acid biosynthesis glycosyl transferase WcaE; This gene is one of the glycosyl ...
 1-248 0e+00

colanic acid biosynthesis glycosyl transferase WcaE; This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.


Pssm-ID: 188524  Cd Length: 248  Bit Score: 510.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841    1 MFLSVITVAFRNYEGVVKTWRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKLNGEFNLRYISEKDKGIYDAMNKGINM 80
Cdd:TIGR04009   1 MLLSVITVAFRNYEGVVKTWRSLRNLARDPSLSFEWIVVDGGSNDGTAEFLEKLNGEFNLRFVSEKDNGIYDAMNKGIAM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   81 AQGRYAIFLNSGDIFHDDVALFARQLARQKEDAMYIGDALLDFGDGHKVCRSAKPGWYIYHSLPASHQAIFFPVKGLKKQ 160
Cdd:TIGR04009  81 AQGRYTLFLNSGDIFHEDVADFVRQLARQKDNAMYIGDALLDFGDGNKIRRSAKPGWYIYHSLPASHQAIFFPTSGLKKY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  161 PYDLQYKVSSDYALAASLYKSGYPFRRIKGLVSEFSMGGVSTSNNLELCQDAKNVQRKILRVPGFWAELSYFLRVRTTSK 240
Cdd:TIGR04009 161 PYDLQYKVSSDYALAAKLYKSGYPFRRIKGLVSEFSMGGVSTSNNLELCQDAKKVQRNILRVPGFWAELSYLLRLKTTGK 240


                  ....*...
gi 495774841  241 TKALYNKA 248
Cdd:TIGR04009 241 TKALYNKA 248
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-204 1.96e-54

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 173.89  E-value: 1.96e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   4 SVITVAFRNYEGVVKTWRSLRNLARDpslTFEWIVVDGGSNDGTAEFLEKLNGEFnLRYISEKDKGIYDAMNKGINMAQG 83
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTYP---NIEYIVIDGGSTDGTVDIIKKYEDKI-TYWISEPDKGIYDAMNKGIALATG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  84 RYAIFLNSGDIFHDDVALF-ARQLARQKEDAMYIGDALLDFGDGHKVCRSAKPGW---YIYHSLPASHQAIFFPVKGLKK 159
Cdd:cd06433   77 DIIGFLNSDDTLLPGALLAvVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFldkFLLYGMPICHQATFFRRSLFEK 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 495774841 160 QP-YDLQYKVSSDYALAASLYKSGYPFRRIKGLVSEFSMGGVSTSN 204
Cdd:cd06433  157 YGgFDESYRIAADYDLLLRLLLAGKIFKYLPEVLAAFRLGGVSSTS 202
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-189 4.67e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 90.15  E-value: 4.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   1 MFLSVITVAFrNYEGVVKtwRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKLNGEF-NLRYIS-EKDKGIYDAMNKGI 78
Cdd:COG0463    2 PLVSVVIPTY-NEEEYLE--EALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDpRIRVIRlERNRGKGAARNAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  79 NMAQGRYAIFLNSGDIFHDDVALFARQLARQKEDAMYIGDALLDFGDG---HKVCRSAKPGWYIYHSLPASHQAIFFPVK 155
Cdd:COG0463   79 AAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREGESdlrRLGSRLFNLVRLLTNLPDSTSGFRLFRRE 158

                        170       180       190
                 ....*....|....*....|....*....|....
gi 495774841 156 GLKKQPYDLQYkvSSDYALAAsLYKSGYPFRRIK 189
Cdd:COG0463  159 VLEELGFDEGF--LEDTELLR-ALRHGFRIAEVP 189
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-98 1.96e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 71.66  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841    4 SVITVAFRNYEGVVKTWRSLRNLARDPsltFEWIVVDGGSNDGTAEFLEKL-NGEFNLRYI-SEKDKGIYDAMNKGINMA 81
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPN---FEIIVVDDGSTDGTVEIAEEYaKKDPRVRVIrLPENRGKAGARNAGLRAA 77

                          90
                  ....*....|....*..
gi 495774841   82 QGRYAIFLNSGDIFHDD 98
Cdd:pfam00535  78 TGDYIAFLDADDEVPPD 94
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 34-95 2.75e-05

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 44.27  E-value: 2.75e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495774841  34 FEWIVVDGGSNDGTAEFLEKLNGEF-NLRYISEKDKGIYDAMNKGINMAQGRYAIFLNSGDIF 95
Cdd:PRK10073  36 LEIIIVNDGSTDNSVEIAKHYAENYpHVRLLHQANAGVSVARNTGLAVATGKYVAFPDADDVV 98
 
Name Accession Description Interval E-value
wcaE TIGR04009
colanic acid biosynthesis glycosyl transferase WcaE; This gene is one of the glycosyl ...
 1-248 0e+00

colanic acid biosynthesis glycosyl transferase WcaE; This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.


Pssm-ID: 188524  Cd Length: 248  Bit Score: 510.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841    1 MFLSVITVAFRNYEGVVKTWRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKLNGEFNLRYISEKDKGIYDAMNKGINM 80
Cdd:TIGR04009   1 MLLSVITVAFRNYEGVVKTWRSLRNLARDPSLSFEWIVVDGGSNDGTAEFLEKLNGEFNLRFVSEKDNGIYDAMNKGIAM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   81 AQGRYAIFLNSGDIFHDDVALFARQLARQKEDAMYIGDALLDFGDGHKVCRSAKPGWYIYHSLPASHQAIFFPVKGLKKQ 160
Cdd:TIGR04009  81 AQGRYTLFLNSGDIFHEDVADFVRQLARQKDNAMYIGDALLDFGDGNKIRRSAKPGWYIYHSLPASHQAIFFPTSGLKKY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  161 PYDLQYKVSSDYALAASLYKSGYPFRRIKGLVSEFSMGGVSTSNNLELCQDAKNVQRKILRVPGFWAELSYFLRVRTTSK 240
Cdd:TIGR04009 161 PYDLQYKVSSDYALAAKLYKSGYPFRRIKGLVSEFSMGGVSTSNNLELCQDAKKVQRNILRVPGFWAELSYLLRLKTTGK 240


                  ....*...
gi 495774841  241 TKALYNKA 248
Cdd:TIGR04009 241 TKALYNKA 248
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-204 1.96e-54

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 173.89  E-value: 1.96e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   4 SVITVAFRNYEGVVKTWRSLRNLARDpslTFEWIVVDGGSNDGTAEFLEKLNGEFnLRYISEKDKGIYDAMNKGINMAQG 83
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTYP---NIEYIVIDGGSTDGTVDIIKKYEDKI-TYWISEPDKGIYDAMNKGIALATG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  84 RYAIFLNSGDIFHDDVALF-ARQLARQKEDAMYIGDALLDFGDGHKVCRSAKPGW---YIYHSLPASHQAIFFPVKGLKK 159
Cdd:cd06433   77 DIIGFLNSDDTLLPGALLAvVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFldkFLLYGMPICHQATFFRRSLFEK 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 495774841 160 QP-YDLQYKVSSDYALAASLYKSGYPFRRIKGLVSEFSMGGVSTSN 204
Cdd:cd06433  157 YGgFDESYRIAADYDLLLRLLLAGKIFKYLPEVLAAFRLGGVSSTS 202
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-189 4.67e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 90.15  E-value: 4.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   1 MFLSVITVAFrNYEGVVKtwRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKLNGEF-NLRYIS-EKDKGIYDAMNKGI 78
Cdd:COG0463    2 PLVSVVIPTY-NEEEYLE--EALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDpRIRVIRlERNRGKGAARNAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  79 NMAQGRYAIFLNSGDIFHDDVALFARQLARQKEDAMYIGDALLDFGDG---HKVCRSAKPGWYIYHSLPASHQAIFFPVK 155
Cdd:COG0463   79 AAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREGESdlrRLGSRLFNLVRLLTNLPDSTSGFRLFRRE 158

                        170       180       190
                 ....*....|....*....|....*....|....
gi 495774841 156 GLKKQPYDLQYkvSSDYALAAsLYKSGYPFRRIK 189
Cdd:COG0463  159 VLEELGFDEGF--LEDTELLR-ALRHGFRIAEVP 189
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-98 1.62e-15

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 72.72  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   1 MFLSVITVAFRNYEGVVKTWRSLRNLARDPsltFEWIVVDGGSNDGTAEFLEKLNGEfNLRYI-SEKDKGIYDAMNKGIN 79
Cdd:COG1216    3 PKVSVVIPTYNRPELLRRCLESLLAQTYPP---FEVIVVDNGSTDGTAELLAALAFP-RVRVIrNPENLGFAAARNLGLR 78

                         90
                 ....*....|....*....
gi 495774841  80 MAQGRYAIFLNSGDIFHDD 98
Cdd:COG1216   79 AAGGDYLLFLDDDTVVEPD 97
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-98 1.96e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 71.66  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841    4 SVITVAFRNYEGVVKTWRSLRNLARDPsltFEWIVVDGGSNDGTAEFLEKL-NGEFNLRYI-SEKDKGIYDAMNKGINMA 81
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPN---FEIIVVDDGSTDGTVEIAEEYaKKDPRVRVIrLPENRGKAGARNAGLRAA 77

                          90
                  ....*....|....*..
gi 495774841   82 QGRYAIFLNSGDIFHDD 98
Cdd:pfam00535  78 TGDYIAFLDADDEVPPD 94
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-121 1.78e-14

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 68.69  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   6 ITVAFRNYEGVVKtwRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKL--NGEFNLRYISEKDKGIYDAMNKGINMAQG 83
Cdd:cd00761    1 VIIPAYNEEPYLE--RCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYakKDPRVIRVINEENQGLAAARNAGLKAARG 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 495774841  84 RYAIFLNSGDIFHDD-VALFARQLARQKEDAMYIGDALL 121
Cdd:cd00761   79 EYILFLDADDLLLPDwLERLVAELLADPEADAVGGPGNL 117
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-98 6.77e-12

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 63.99  E-value: 6.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   1 MFLSVITVAFRNYEGVVKTWRSLRNLARdPSLTFEWIVVDGGSNDGTAEFLEKLNGEF-NLRYIS-EKDKGIYDAMNKGI 78
Cdd:COG1215   29 PRVSVIIPAYNEEAVIEETLRSLLAQDY-PKEKLEVIVVDDGSTDETAEIARELAAEYpRVRVIErPENGGKAAALNAGL 107

                         90       100
                 ....*....|....*....|
gi 495774841  79 NMAQGRYAIFLNSGDIFHDD 98
Cdd:COG1215  108 KAARGDIVVFLDADTVLDPD 127
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-113 5.83e-11

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 59.11  E-value: 5.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   5 VITVAFRNYEGVVKTWRSLRNLARDPsltFEWIVVDGGSNDGTAEFLEKLNGEFNLrYISEKDKGIYDAMNKGINMAQGR 84
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPD---FEVIVVDNASTDGSVELLRELFPEVRL-IRNGENLGFGAGNNQGIREAKGD 76

                         90       100
                 ....*....|....*....|....*....
gi 495774841  85 YAIFLNSGDIFHDDVALFARQLARQKEDA 113
Cdd:cd04186   77 YVLLLNPDTVVEPGALLELLDAAEQDPDV 105
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 2-89 1.69e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 53.77  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   2 FLSVITVAfRNYEG-VVKTWRSLRNLaRDPSLTFEWIVVDGGSNDGTAEFLEKLNGEFN-LRYISEKDKGIYDAMNKGIN 79
Cdd:cd02525    1 FVSIIIPV-RNEEKyIEELLESLLNQ-SYPKDLIEIIVVDGGSTDGTREIVQEYAAKDPrIRLIDNPKRIQSAGLNIGIR 78

                         90
                 ....*....|
gi 495774841  80 MAQGRYAIFL 89
Cdd:cd02525   79 NSRGDIIIRV 88
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 5-112 2.86e-08

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 52.19  E-value: 2.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   5 VITVAFRNYEGVVKTWRSLRNLARDPsLTFEWIVVDGGSNDGTAEFLEKLNGEF-NLRYIS-EKDKGIYDAMNKGINMAQ 82
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAVLEEG-YDYEIIVVDDGSTDGTAEIARELAARVpRVRVIRlSRNFGKGAAVRAGFKAAR 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 495774841  83 GRYAIFLNsGDIFHD--DVALFARQLARQKED 112
Cdd:cd04179   80 GDIVVTMD-ADLQHPpeDIPKLLEKLLEGGAD 110
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 23-109 8.42e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 48.34  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  23 LRNLARDPSLTFEWIVVDGGSNDGTAEFLEklngEFNLRYISEKdKGIYDAMNKGINMAQGRYAIFLNSGDIFHDDVALF 102
Cdd:cd02522   18 LASLRRLNPLPLEIIVVDGGSTDGTVAIAR----SAGVVVISSP-KGRARQMNAGAAAARGDWLLFLHADTRLPPDWDAA 92


                 ....*..
gi 495774841 103 ARQLARQ 109
Cdd:cd02522   93 IIETLRA 99
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 34-137 1.91e-06

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 47.20  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  34 FEWIVVDGGS-NDGTAEFLEKL-NGEFNLRYI-SEKDKGIYDAMNKGINMAQGRYAIFLNSGDIFHDDvALF--ARQLAR 108
Cdd:cd04184   32 WELCIADDAStDPEVKRVLKKYaAQDPRIKVVfREENGGISAATNSALELATGEFVALLDHDDELAPH-ALYevVKALNE 110

                         90       100       110
                 ....*....|....*....|....*....|
gi 495774841 109 QKE-DAMYIGDALLDfGDGHKVCRSAKPGW 137
Cdd:cd04184  111 HPDaDLIYSDEDKID-EGGKRSEPFFKPDW 139
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-88 4.29e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 46.51  E-value: 4.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   6 ITVAFRN-YEGVVKTWRSLRNLARdPSLTFEWIVVDGGSNDGTAEFLE--KLNGEFNLRYISEKDKGIY---DAMNKGIN 79
Cdd:cd04192    1 VVIAARNeAENLPRLLQSLSALDY-PKEKFEVILVDDHSTDGTVQILEfaAAKPNFQLKILNNSRVSISgkkNALTTAIK 79


                 ....*....
gi 495774841  80 MAQGRYAIF 88
Cdd:cd04192   80 AAKGDWIVT 88
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 8-113 8.40e-06

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 44.91  E-value: 8.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   8 VAFRNYEGVV-KTWRSLRNLARDPsltFEWIVVDGGSNDGTAEFLEKLNGEFNLRYI---SEKDKGIYDAMNKGINMAQG 83
Cdd:cd06423    3 VPAYNEEAVIeRTIESLLALDYPK---LEVIVVDDGSTDDTLEILEELAALYIRRVLvvrDKENGGKAGALNAGLRHAKG 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 495774841  84 RYAIFLNSGDIFHDDVALFARQLARQKEDA 113
Cdd:cd06423   80 DIVVVLDADTILEPDALKRLVVPFFADPKV 109
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 34-95 2.75e-05

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 44.27  E-value: 2.75e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495774841  34 FEWIVVDGGSNDGTAEFLEKLNGEF-NLRYISEKDKGIYDAMNKGINMAQGRYAIFLNSGDIF 95
Cdd:PRK10073  36 LEIIIVNDGSTDNSVEIAKHYAENYpHVRLLHQANAGVSVARNTGLAVATGKYVAFPDADDVV 98
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 4-108 2.79e-05

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 44.11  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   4 SVITVAFrNYEGVVKtwRSLRNLARD--PSLTFEWIVVDGGSNDGTAEFLEKLNGEFNLRYISEKDKGIYDAMNKGINMA 81
Cdd:cd06439   32 TIIIPAY-NEEAVIE--AKLENLLALdyPRDRLEIIVVSDGSTDGTAEIAREYADKGVKLLRFPERRGKAAALNRALALA 108

                         90       100
                 ....*....|....*....|....*..
gi 495774841  82 QGRYAIFLNSGDIFHDDvALfaRQLAR 108
Cdd:cd06439  109 TGEIVVFTDANALLDPD-AL--RLLVR 132
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 21-95 3.89e-05

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 42.95  E-value: 3.89e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495774841  21 RSLRNLARDPsltFEWIVVDGGSNDGTAEFLEKLNGEFN--LRYISEKDKGIYDA--MNKGINMAQGRYAIFLNsGDIF 95
Cdd:cd06420   17 KSVLNQSILP---FEVIIADDGSTEETKELIEEFKSQFPipIKHVWQEDEGFRKAkiRNKAIAAAKGDYLIFID-GDCI 91
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 5-113 3.97e-05

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 42.85  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   5 VITVaFRNYEGVVKTWRSLRNLARDPSLTFEWIVVDGGSNDGTAEFLEKLNGEF-NLRYIS-EKDKGIYDAMNKGINMAQ 82
Cdd:cd04187    2 VVPV-YNEEENLPELYERLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDpRVKVIRlSRNFGQQAALLAGLDHAR 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 495774841  83 GRYAIFLnSGDiFHDDVALFARQLARQKEDA 113
Cdd:cd04187   81 GDAVITM-DAD-LQDPPELIPEMLAKWEEGY 109
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 26-89 5.74e-04

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 39.86  E-value: 5.74e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495774841  26 LARDPSLTFEWIVVDGGSNDGTAEFLEKL---NGEFNLRYISEKDKGIYDAMNKGINMAQGRYAIFL 89
Cdd:cd04188   23 LEERPSFSYEIIVVDDGSKDGTAEVARKLarkNPALIRVLTLPKNRGKGGAVRAGMLAARGDYILFA 89
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 1-91 1.14e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 39.37  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841   1 MFLSVITVAFRNYEGVVKTWRSL-----RNLARDPSLTFEWIVVDGGSNDGTAE-----FLEKLNGEFNLRYIS-EKDKG 69
Cdd:PTZ00260  70 VDLSIVIPAYNEEDRLPKMLKETikyleSRSRKDPKFKYEIIIVNDGSKDKTLKvakdfWRQNINPNIDIRLLSlLRNKG 149

                         90       100
                 ....*....|....*....|..
gi 495774841  70 IYDAMNKGINMAQGRYAIFLNS 91
Cdd:PTZ00260 150 KGGAVRIGMLASRGKYILMVDA 171
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 23-89 1.36e-03

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 38.65  E-value: 1.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495774841   23 LRNLARDPSlTFEWIVVDGGSNDGTAEFLEklngEFNLRYI-SEKDKGIydAMNKGINMAQGRYAIFL 89
Cdd:TIGR04283  18 LADLQALRG-DAEVIVVDGGSTDGTVEIAR----SLGAKVIhSPKGRAR--QMNAGAALAKGDILLFL 78
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 13-96 2.54e-03

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 38.14  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495774841  13 YEGVVKTWRSLRNLA----------RDPSlTFEWIVVDGGSNDGTAEF---LEKLNGEFNLRYISEKDK-GIYDAMNKGI 78
Cdd:PLN02726  11 YSIIVPTYNERLNIAlivylifkalQDVK-DFEIIVVDDGSPDGTQDVvkqLQKVYGEDRILLRPRPGKlGLGTAYIHGL 89

                         90
                 ....*....|....*...
gi 495774841  79 NMAQGRYAIFLNSgDIFH 96
Cdd:PLN02726  90 KHASGDFVVIMDA-DLSH 106
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 22-81 2.68e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 38.00  E-value: 2.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495774841  22 SLRNLARDPSltfEWIVVDGGSNDGTAEFLEKLNGEFNLRYIS-EKDKGIYDAMNKGINMA 81
Cdd:cd04185   18 ALLAQTRPPD---HIIVIDNASTDGTAEWLTSLGDLDNIVYLRlPENLGGAGGFYEGVRRA 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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