|
Name |
Accession |
Description |
Interval |
E-value |
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
1-795 |
0e+00 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 1185.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVNTTLDSDALSNQITMAGLEVDGVEPVSGAFNGVVVGEVVECGQHPNADKLRVTKVNVGgDRLLDIVCG 80
Cdd:PRK00629 1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVG-EEPLQIVCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 81 APNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIEI 160
Cdd:PRK00629 80 APNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLDDTVIEI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 161 SVTPNRADCLGIIGVARDVAVLNQTELNAPEIAPVEATISDVLPIQVDAADACPRYLGRVVKGINVKAPTPLWMKEKLRR 240
Cdd:PRK00629 160 SLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWLQERLRA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 241 CGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIFGGE 320
Cdd:PRK00629 240 AGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALAGVMGGE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 321 HSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAgpVIDVTNEATL 400
Cdd:PRK00629 320 DSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEV--VEGVVDVYPL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 401 PKRATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVT-EGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEPV 479
Cdd:PRK00629 398 PKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTeVDGDGLTVTVPSWRFDIEIEEDLVEEVARIYGYDNIPSTPP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 480 QAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKLQQLIHPGQEALILPSPISSEMSAMRLSLWTGLLGTIVYN 559
Cdd:PRK00629 478 VAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEAVAYN 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 560 QNRQQNRVRIFESGLRFVPDnqaNLGIRQDLMLAGAISGNRYEEHWDlAKGTVDFYDMKGDLEAILDLTGKLSEIEFRAE 639
Cdd:PRK00629 558 LNRGNKDVALFEIGRVFLPD---GDLPREPEHLAGVLTGNRVEESWG-GKRPVDFFDLKGDVEALLEALGLPEVEFVAEF 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 640 AIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLV--ADRVIPQAQDVSRFPANRRDIAVVVAEN 717
Cdd:PRK00629 634 EAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALleAARKLPKYKPISKFPAVRRDLALVVDED 713
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495776075 718 VPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLRD 795
Cdd:PRK00629 714 VPAADILKAIKKAGGKLLESVELFDVYEGKGIGEGKKSLAFRLTFQDPDRTLTDEEINAAMDKIVAALEEKFGAELRG 791
|
|
| PheT |
COG0072 |
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
1-795 |
0e+00 |
|
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 1146.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVNTTLDSDALSNQITMAGLEVDGVEPVSGAFNGVVVGEVVECGQHPNADKLRVTKVNVGGDRLLDIVCG 80
Cdd:COG0072 1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 81 APNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIEI 160
Cdd:COG0072 81 AANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGVESSGMLCSEEELGLGEDHDGIIVLPPDAPVGGDAREYLGLDDTVLEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 161 SVTPNRADCLGIIGVARDVAVLNQTELNAPEIAP-VEATISDVLPIQVDAADACPRYLGRVVKGINVKaPTPLWMKEKLR 239
Cdd:COG0072 161 DLTPNRADCLSVRGVARELAALLGAPLKLPAIEPeVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKVG-PSPLWMQERLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 240 RCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIFGG 319
Cdd:COG0072 240 AAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLALAGVMGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 320 EHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAGP-VIDVTNEA 398
Cdd:COG0072 320 EDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIVDVYPEP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 399 tlPKRATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTEGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEP 478
Cdd:COG0072 400 --PEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFDIEIEADLIEEVARIYGYDNIPSTL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 479 VQAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKLQQLIHPGQEALILPSPISSEMSAMRLSLWTGLLGTIVY 558
Cdd:COG0072 478 PRAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLEAAAY 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 559 NQNRQQNRVRIFESGLRFVPDNQANLgiRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGkLSEIEFRA 638
Cdd:COG0072 558 NLNRGQKDVRLFEIGRVFLPDEGEEP--REPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEALLAALG-VPKLEFEA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 639 EAIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLV--ADRVIPQAQDVSRFPANRRDIAVVVAE 716
Cdd:COG0072 635 AEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALleLARKVPKYKPISKFPAVRRDLALVVDE 714
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495776075 717 NVPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLRD 795
Cdd:COG0072 715 DVPAADVLDAIRKAAGKLLEDVRLFDVYEGKGVPEGKKSLAFSLTLQDPDRTLTDEEIDAAMDKIVAALEKKFGAELRG 793
|
|
| pheT_bact |
TIGR00472 |
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
1-794 |
0e+00 |
|
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 1007.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVN-TTLDSDALSNQITMAGLEVDGVEPVSGAFNGVVVGEVVECGQHPNADKLRVTKVNVGGDRLLDIVC 79
Cdd:TIGR00472 1 MKISLKWLREYVPlSEIDNEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 80 GAPNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIE 159
Cdd:TIGR00472 81 GAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSESELGLDEKSDGIIVLDEDAPLGTDIAEYLGLDDDIIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 160 ISVTPNRADCLGIIGVARDVAVLNQT--ELNAPEIAPVEATISDVLPIQVDAADACPRYLGRVVKGINVKaPTPLWMKEK 237
Cdd:TIGR00472 161 VSITPNRGDCLSILGIARELAALFDLnlETPVPFEPETTETIDEGFKIEIEDPEVCPFYLGRVIKGVKVK-PSPLWLKER 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 238 LRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIF 317
Cdd:TIGR00472 240 LRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPLAIAGVM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 318 GGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAGPVIdVTNE 397
Cdd:TIGR00472 320 GGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGEVISVV-SDNY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 398 ATLPKRATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTEGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDE 477
Cdd:TIGR00472 399 KEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYDNIPAE 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 478 PVQAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDP-KLQQLIHPGQEALI-LPSPISSEMSAMRLSLWTGLLGT 555
Cdd:TIGR00472 479 PLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPeKAEKFNFPKLENLVeIKNPLSNERSVLRTSLLPSLLEV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 556 IVYNQNRQQNRVRIFESGLRFVPDNQAnlgIRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGKLSEIE 635
Cdd:TIGR00472 559 LAYNQNRKNKDVKIFEIGKVFAKDGEA---VKEQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDVESLLELLGLSDDVY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 636 FRAEA-IPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLVADR--VIPQAQDVSRFPANRRDIAV 712
Cdd:TIGR00472 636 FKNTAeNEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLLESlkKVPKYRPISKFPAVTRDISF 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 713 VVAENVPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQAS 792
Cdd:TIGR00472 716 LVPKDVPANEIIKLIKKSGLELLEEVELFDVYQGKNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALKEKLGAE 795
|
..
gi 495776075 793 LR 794
Cdd:TIGR00472 796 LR 797
|
|
| B3_4 |
pfam03483 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
212-385 |
2.33e-97 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 427327 [Multi-domain] Cd Length: 174 Bit Score: 299.85 E-value: 2.33e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 212 ACPRYLGRVVKGINVKAPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLD 291
Cdd:pfam03483 1 ACPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 292 GTEAKLNADTLVIADHSKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYK 371
Cdd:pfam03483 81 GKERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEA 160
|
170
....*....|....
gi 495776075 372 AMERATRLLIDICG 385
Cdd:pfam03483 161 ALDRATALLLELCG 174
|
|
| B3_4 |
smart00873 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
213-385 |
3.12e-79 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 214876 [Multi-domain] Cd Length: 174 Bit Score: 252.18 E-value: 3.12e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 213 CPRYLGRVVKGINVKAPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGG-IVVRMAKEGETLVLLD 291
Cdd:smart00873 1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 292 GTEAKLNADTLVIADHSKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYK 371
Cdd:smart00873 81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160
|
170
....*....|....
gi 495776075 372 AMERATRLLIDICG 385
Cdd:smart00873 161 ALDRAAALLLEICG 174
|
|
| PheRS_beta_core |
cd00769 |
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ... |
495-689 |
2.61e-71 |
|
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.
Pssm-ID: 238392 [Multi-domain] Cd Length: 198 Bit Score: 232.15 E-value: 2.61e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 495 LKRVKTMLNDKGYQEVITYSFVDPKLQQLI-HPGQEALILPSPISSEMSAMRLSLWTGLLGTIVYNQNRQQNRVRIFESG 573
Cdd:cd00769 6 ERKLRRLLAGLGFQEVITYSLTSPEEAELFdGGLDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLRLFEIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 574 LRFVPDNQanlGIRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGKLSEIEFRAEAIPALHPGQSAALY 653
Cdd:cd00769 86 RVFLKDED---GPEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEALLRALGIIVEFELEELDADLFHPGRSAKIY 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 495776075 654 LDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLV 689
Cdd:cd00769 163 VNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
1-795 |
0e+00 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 1185.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVNTTLDSDALSNQITMAGLEVDGVEPVSGAFNGVVVGEVVECGQHPNADKLRVTKVNVGgDRLLDIVCG 80
Cdd:PRK00629 1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVG-EEPLQIVCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 81 APNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIEI 160
Cdd:PRK00629 80 APNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLDDTVIEI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 161 SVTPNRADCLGIIGVARDVAVLNQTELNAPEIAPVEATISDVLPIQVDAADACPRYLGRVVKGINVKAPTPLWMKEKLRR 240
Cdd:PRK00629 160 SLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWLQERLRA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 241 CGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIFGGE 320
Cdd:PRK00629 240 AGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALAGVMGGE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 321 HSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAgpVIDVTNEATL 400
Cdd:PRK00629 320 DSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEV--VEGVVDVYPL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 401 PKRATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVT-EGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEPV 479
Cdd:PRK00629 398 PKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTeVDGDGLTVTVPSWRFDIEIEEDLVEEVARIYGYDNIPSTPP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 480 QAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKLQQLIHPGQEALILPSPISSEMSAMRLSLWTGLLGTIVYN 559
Cdd:PRK00629 478 VAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEAVAYN 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 560 QNRQQNRVRIFESGLRFVPDnqaNLGIRQDLMLAGAISGNRYEEHWDlAKGTVDFYDMKGDLEAILDLTGKLSEIEFRAE 639
Cdd:PRK00629 558 LNRGNKDVALFEIGRVFLPD---GDLPREPEHLAGVLTGNRVEESWG-GKRPVDFFDLKGDVEALLEALGLPEVEFVAEF 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 640 AIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLV--ADRVIPQAQDVSRFPANRRDIAVVVAEN 717
Cdd:PRK00629 634 EAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALleAARKLPKYKPISKFPAVRRDLALVVDED 713
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495776075 718 VPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLRD 795
Cdd:PRK00629 714 VPAADILKAIKKAGGKLLESVELFDVYEGKGIGEGKKSLAFRLTFQDPDRTLTDEEINAAMDKIVAALEEKFGAELRG 791
|
|
| PheT |
COG0072 |
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
1-795 |
0e+00 |
|
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 1146.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVNTTLDSDALSNQITMAGLEVDGVEPVSGAFNGVVVGEVVECGQHPNADKLRVTKVNVGGDRLLDIVCG 80
Cdd:COG0072 1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 81 APNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIEI 160
Cdd:COG0072 81 AANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGVESSGMLCSEEELGLGEDHDGIIVLPPDAPVGGDAREYLGLDDTVLEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 161 SVTPNRADCLGIIGVARDVAVLNQTELNAPEIAP-VEATISDVLPIQVDAADACPRYLGRVVKGINVKaPTPLWMKEKLR 239
Cdd:COG0072 161 DLTPNRADCLSVRGVARELAALLGAPLKLPAIEPeVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKVG-PSPLWMQERLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 240 RCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIFGG 319
Cdd:COG0072 240 AAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLALAGVMGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 320 EHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAGP-VIDVTNEA 398
Cdd:COG0072 320 EDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIVDVYPEP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 399 tlPKRATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTEGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEP 478
Cdd:COG0072 400 --PEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFDIEIEADLIEEVARIYGYDNIPSTL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 479 VQAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKLQQLIHPGQEALILPSPISSEMSAMRLSLWTGLLGTIVY 558
Cdd:COG0072 478 PRAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLEAAAY 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 559 NQNRQQNRVRIFESGLRFVPDNQANLgiRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGkLSEIEFRA 638
Cdd:COG0072 558 NLNRGQKDVRLFEIGRVFLPDEGEEP--REPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEALLAALG-VPKLEFEA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 639 EAIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLV--ADRVIPQAQDVSRFPANRRDIAVVVAE 716
Cdd:COG0072 635 AEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALleLARKVPKYKPISKFPAVRRDLALVVDE 714
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495776075 717 NVPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLRD 795
Cdd:COG0072 715 DVPAADVLDAIRKAAGKLLEDVRLFDVYEGKGVPEGKKSLAFSLTLQDPDRTLTDEEIDAAMDKIVAALEKKFGAELRG 793
|
|
| pheT_bact |
TIGR00472 |
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
1-794 |
0e+00 |
|
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 1007.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVN-TTLDSDALSNQITMAGLEVDGVEPVSGAFNGVVVGEVVECGQHPNADKLRVTKVNVGGDRLLDIVC 79
Cdd:TIGR00472 1 MKISLKWLREYVPlSEIDNEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 80 GAPNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIE 159
Cdd:TIGR00472 81 GAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSESELGLDEKSDGIIVLDEDAPLGTDIAEYLGLDDDIIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 160 ISVTPNRADCLGIIGVARDVAVLNQT--ELNAPEIAPVEATISDVLPIQVDAADACPRYLGRVVKGINVKaPTPLWMKEK 237
Cdd:TIGR00472 161 VSITPNRGDCLSILGIARELAALFDLnlETPVPFEPETTETIDEGFKIEIEDPEVCPFYLGRVIKGVKVK-PSPLWLKER 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 238 LRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIF 317
Cdd:TIGR00472 240 LRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPLAIAGVM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 318 GGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAGPVIdVTNE 397
Cdd:TIGR00472 320 GGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGEVISVV-SDNY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 398 ATLPKRATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTEGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDE 477
Cdd:TIGR00472 399 KEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYDNIPAE 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 478 PVQAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDP-KLQQLIHPGQEALI-LPSPISSEMSAMRLSLWTGLLGT 555
Cdd:TIGR00472 479 PLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPeKAEKFNFPKLENLVeIKNPLSNERSVLRTSLLPSLLEV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 556 IVYNQNRQQNRVRIFESGLRFVPDNQAnlgIRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGKLSEIE 635
Cdd:TIGR00472 559 LAYNQNRKNKDVKIFEIGKVFAKDGEA---VKEQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDVESLLELLGLSDDVY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 636 FRAEA-IPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLVADR--VIPQAQDVSRFPANRRDIAV 712
Cdd:TIGR00472 636 FKNTAeNEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLLESlkKVPKYRPISKFPAVTRDISF 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 713 VVAENVPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQAS 792
Cdd:TIGR00472 716 LVPKDVPANEIIKLIKKSGLELLEEVELFDVYQGKNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALKEKLGAE 795
|
..
gi 495776075 793 LR 794
Cdd:TIGR00472 796 LR 797
|
|
| EMAP |
COG0073 |
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis]; |
1-774 |
2.00e-169 |
|
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
Pssm-ID: 439843 [Multi-domain] Cd Length: 773 Bit Score: 508.24 E-value: 2.00e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 1 MKFSELWLREWVNTTLDSDALSNQITMAGLEVDGVEPVsGAFNGVVVGEVVECGQHPNADKLRVTKVNVGgDRLLDIVCG 80
Cdd:COG0073 1 MKVSLSWLKEYVDLDLSPEELAEKLTMAGIEVEDFEKV-GGLDGLRVGKVLEAEPHPNADKLLVLQVDVG-EETRQIVCG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 81 APNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHNGIIELPLDAPIGTDIREYLKLDDNTIEI 160
Cdd:COG0073 79 APNVYAGDKVPEALVGAQVPGVVNLKPRKIRGVESEGMLCSAEELGLGEDHDGILELPEDAPPGDDAEYLLLLDDVIIEI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 161 SVTPNRADCLGIIGVARDVAVLNQTELNAPEIAPVEATISDVLPIQVDAADACPRYLGRVVKGINVKAPTPLWMKEKLRR 240
Cdd:COG0073 159 LTTPNRDDLLSVGGAAREAAALGGLLLKPPAPPVVEGTDDAVLVVVVDDDACDRYYGRVVRGVVNVVVPPPPWLRRLLRR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 241 CGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIeGGIVVRMAKEGETLVLLDGTEAKLNADTLVIADHSKALAMGGIFGGE 320
Cdd:COG0073 239 GGRRRIINVVDINNVVLLLLGQPHHAFDDDDL-GGGIVVRRRRAEELLLLLLGDTTLLLDDLLLIDDDDDALAAAGGGGG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 321 HSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRLLIDICGGEAGPVIDVTNEATL 400
Cdd:COG0073 318 GGGSSGSTTTTTLLLAAAAFFAAAGRRRRRRRLSSRSSRRRRREDDDDPRVAAAAAAAALLLIILGGGGGVAGGVVDEGL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 401 PKRA-TITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTEGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGYNNIPDEPV 479
Cdd:COG0073 398 PPPPpRIIRLRRRRRLLLLGIDIDEEELLLLLLLLGFEVEGEGESVVVPPPRRRDDVIEEDEEEEEARRYYYYDLPPPPP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 480 QAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKLQQLIHPGQEALILPSPISSEMSAMRLSLWTGLLGTIVYN 559
Cdd:COG0073 478 PAPPAVPEPPAARRRLRRRRRLLLLLGLEEAVTYSSFSELLLALLLLFEAALLLLLPPSSLSSSLLLSLLLLLLLLVLLL 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 560 QNRQQNRVRIFESGLRFVPDNQANLGIRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGKLSEIEFRAE 639
Cdd:COG0073 558 LRRRNRNRRLFEGGEVFFGFEGGGLELLLAELEAGGALLLGGGGGAALGLAADDADDLAGVLLLLALLLGLLALLALAAA 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 640 AIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLVADRVIPQAQDVSRFPANRRDIAVVVAENVP 719
Cdd:COG0073 638 APAAAAPGAGGAGGLLLGGGGGLGGLLPVLLKLLLLLLLALLFEVLLDELLLPAAVLLALPLVARPLLRAIVVDVAAAVA 717
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 495776075 720 AADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEI 774
Cdd:COG0073 718 AALAAVAAALALVVALLAVVLLVVVVDVGVGKVLKKLLLSLDLEVTLLDLEELEL 772
|
|
| B3_4 |
pfam03483 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
212-385 |
2.33e-97 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 427327 [Multi-domain] Cd Length: 174 Bit Score: 299.85 E-value: 2.33e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 212 ACPRYLGRVVKGINVKAPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLD 291
Cdd:pfam03483 1 ACPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 292 GTEAKLNADTLVIADHSKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYK 371
Cdd:pfam03483 81 GKERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEA 160
|
170
....*....|....
gi 495776075 372 AMERATRLLIDICG 385
Cdd:pfam03483 161 ALDRATALLLELCG 174
|
|
| B3_4 |
smart00873 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
213-385 |
3.12e-79 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 214876 [Multi-domain] Cd Length: 174 Bit Score: 252.18 E-value: 3.12e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 213 CPRYLGRVVKGINVKAPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGG-IVVRMAKEGETLVLLD 291
Cdd:smart00873 1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 292 GTEAKLNADTLVIADHSKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYK 371
Cdd:smart00873 81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160
|
170
....*....|....
gi 495776075 372 AMERATRLLIDICG 385
Cdd:smart00873 161 ALDRAAALLLEICG 174
|
|
| PheRS_beta_core |
cd00769 |
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ... |
495-689 |
2.61e-71 |
|
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.
Pssm-ID: 238392 [Multi-domain] Cd Length: 198 Bit Score: 232.15 E-value: 2.61e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 495 LKRVKTMLNDKGYQEVITYSFVDPKLQQLI-HPGQEALILPSPISSEMSAMRLSLWTGLLGTIVYNQNRQQNRVRIFESG 573
Cdd:cd00769 6 ERKLRRLLAGLGFQEVITYSLTSPEEAELFdGGLDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLRLFEIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 574 LRFVPDNQanlGIRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGKLSEIEFRAEAIPALHPGQSAALY 653
Cdd:cd00769 86 RVFLKDED---GPEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEALLRALGIIVEFELEELDADLFHPGRSAKIY 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 495776075 654 LDGKRIGFIGVVHPELERKLDLNGRTIVFELEWNLV 689
Cdd:cd00769 163 VNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
|
|
| tRNA_synthFbeta |
pfam17759 |
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic ... |
474-686 |
1.04e-69 |
|
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase.
Pssm-ID: 465487 [Multi-domain] Cd Length: 214 Bit Score: 228.20 E-value: 1.04e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 474 IPDEPVQAGLVMGTHREADLSLKRVKTMLNDKGYQEVITYSFVDPKLQQLI---HPGQEALILPSPISSEMSAMRLSLWT 550
Cdd:pfam17759 1 IPSTLPKGPTTGGGLTPEQKLRRRVRDLLAAAGFTEVITYSFTSPKDLDKLledDPRRKAVKLANPLSEELSVMRTSLLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 551 GLLGTIVYNQNRQQNRVRIFESGLRFVPDNQANLgIRQDLMLAGAISGNRYEEHWDLAKGTVDFYDMKGDLEAILDLTGk 630
Cdd:pfam17759 81 GLLETLAYNLNRGNPDVRLFEIGRVFLPDELEEL-PREPRRLAGLLTGKRLPESWQGKARPVDFYDLKGIVEALLAALG- 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 495776075 631 LSEIEFRAEAIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELEW 686
Cdd:pfam17759 159 IDDYEFEAADHPALHPGRSAEILVGGKVIGFIGELHPEVAKNFDLPQPVYVFELDL 214
|
|
| syfB |
CHL00192 |
phenylalanyl-tRNA synthetase beta chain; Provisional |
154-794 |
1.27e-66 |
|
phenylalanyl-tRNA synthetase beta chain; Provisional
Pssm-ID: 214391 [Multi-domain] Cd Length: 704 Bit Score: 234.60 E-value: 1.27e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 154 DDNTIEISVTPNRADCLGIIGVARDVAVL-NQTELNAPEIAPVEA------TISDVLPIQVDaadaCPRYLGRVVKGINV 226
Cdd:CHL00192 45 SDIILDISSTANRSDVLSIQGLSREISALfNSDPIKLKYYNPSISwfdklkNLISNDSSKLN----CSMFIAVIIENIEI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 227 KaPTPLWMKEKLRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEG-------GIVVRMAKEGETLVLLDGTEAKLNA 299
Cdd:CHL00192 121 K-DSPKWLQNRLSSSGFKSLNNLTDIQNYIMLETGQPIEIYDLDKIYSknttsslALSSKFALQKSSFIASNSKNIELEN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 300 DTLVIADHSKALAMGGIFGGEHSGVNDETQNVLLECAFFSPLSITGRARRHGLHTDASHRYERGVDPALQYKAMERATRL 379
Cdd:CHL00192 200 NILVVQANNVIISIAGIISNEEIICDKNTKSILIEASIFDAAVIRKSSRKLGLRTDRSIRYEKSLKNDNLLEAYYRLVSL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 380 LidicgGEAGPviDVTNEATLPKRAT------ITLRRSKLDRLIG--------HHVADAQVTDILKRLGCDVTEGQDE-- 443
Cdd:CHL00192 280 L-----RILNP--KLKCKFHFIYKKIknssrrIKLSYKKIKDILGpikintntRYLSPKEITNALKRLNFKITYDSLKln 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 444 WKAVAPSWR-FDMEIEEDLVEEVARVYGYNN-IPDEPVQAGLVMGTHREAdlSLKRVKTMLNDKGYQEVITYSFVDpklQ 521
Cdd:CHL00192 353 WEVLIPSYRkDDIVREIDVIEEIARIYGFNNfLSKLPNIKFIGRLDIDYN--TRDKIRSYLRNLGLTELIHYSLVK---Q 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 522 QLIHPGQEALIlpSPISSEMSAMRLSLWTGLLGTIVYNQNRQQNRVRIFESGLRFVPDNQanlGIRQDLMLAGAISGN-R 600
Cdd:CHL00192 428 ESFSKNEIKLK--NPLIKDYSTLRSSLLPGLIEAVQENLKQGNSTLEGFEIGHVFNLDSS---SIIEETELAGGIFGGiD 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 601 YEEHWDLAKGTVDFYDMKGDLEAILDLTGKLSEIEFRA---EAIpALHPGQSAALYL-DGKRIGFIGVVHPELERKLDLN 676
Cdd:CHL00192 503 IRSSWSEKAQSLNWFEAKGIIENFFQKLNLPIYWKKYSdldEKI-NFHPYCTSEIFLsNGQKIGIFGQLHPLLANKLNLN 581
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 677 GRTIVFELEWNLVaDRVIPQ-----AQDVSRFPANRRDIAVVVAENVPAADILAECKKVGVNQVVGVNLFDVYRGKGVAE 751
Cdd:CHL00192 582 TEIYLFEINLDIL-QYSIQQnnlisYQPYSSYPKIIRDLSFIIKKSISISKIKELIYQNGDNLLESITLFDYYKGKSIPN 660
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 495776075 752 GFKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLR 794
Cdd:CHL00192 661 GHTSLGLRLTFQSENKTLTNEEIDRIQQNLQKVLEKKLNAEIR 703
|
|
| tRNA_bind_bactPheRS |
cd02796 |
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ... |
53-147 |
9.88e-49 |
|
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.
Pssm-ID: 239196 [Multi-domain] Cd Length: 103 Bit Score: 166.91 E-value: 9.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 53 CGQHPNADKLRVTKVNVGGDRLLDIVCGAPNCRQGLKVAVATVGAVLPGDFKIKAAKLRGEPSEGMLCSFSELGISDDHN 132
Cdd:cd02796 9 VEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLPGGLKIKKRKLRGVESEGMLCSAKELGLGEDSD 88
|
90
....*....|....*
gi 495776075 133 GIIELPLDAPIGTDI 147
Cdd:cd02796 89 GIIELPEDAPVGTDI 103
|
|
| FDX-ACB |
smart00896 |
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
701-794 |
1.53e-33 |
|
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2).
Pssm-ID: 214893 [Multi-domain] Cd Length: 93 Bit Score: 123.69 E-value: 1.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 701 SRFPANRRDIAVVVAENVPAADILAECKKVGVNQVVGVNLFDVYRGkGVAEGFKSLAISLILQDTSRTLEEEEIAATVAK 780
Cdd:smart00896 1 SKFPAVRRDLAFVVDEDVPAAELLDAIREAGGDLLEDVRLFDVYEG-GIPEGKKSLAYRLTYQSPDRTLTDEEVNAIHDK 79
|
90
....*....|....
gi 495776075 781 CVEALKERFQASLR 794
Cdd:smart00896 80 IVAALEKKFGAELR 93
|
|
| FDX-ACB |
pfam03147 |
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
701-794 |
2.93e-33 |
|
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold.
Pssm-ID: 460826 [Multi-domain] Cd Length: 94 Bit Score: 122.98 E-value: 2.93e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 701 SRFPANRRDIAVVVAENVPAADILAECKKVGVNQVVGVNLFDVYRGKGVAEGFKSLAISLILQDTSRTLEEEEIAATVAK 780
Cdd:pfam03147 1 SKYPAVRRDLAFVVDEDVPAADILKAIREAGGELLESVELFDVYRGEKIPEGKKSLAFRLTFQSPERTLTDEEVNAIIEK 80
|
90
....*....|....
gi 495776075 781 CVEALKERFQASLR 794
Cdd:pfam03147 81 IVEALEKKFGAELR 94
|
|
| tRNA_bindingDomain |
cd02153 |
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in ... |
53-147 |
4.87e-30 |
|
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-tRNA synthetase(hTyrRS), Saccharomyces cerevisiae Arc1p, Thermus thermophilus CsaA, Aquifex aeolicus Trbp111, human p43 and human EMAP-II. PheRS, MetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. The molecular chaperones Trbp111 and CsaA also contain this domain. CsaA has export related activities; Trbp111 is structure-specific recognizing the L-shape of the tRNA fold. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. An EMAP-II-like cytokine is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain. For homodimeric members of this group which include CsaA, Trbp111 and Escherichia coli MetRS this domain acts as a dimerization domain.
Pssm-ID: 239066 [Multi-domain] Cd Length: 99 Bit Score: 114.15 E-value: 4.87e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 53 CGQHPNADKLRVTKVNVGGDRLLDIVCGAPNC-----RQGLKVAVATVgavlpgdfkIKAAKLRGEPSEGMLCSFSELGI 127
Cdd:cd02153 9 AEPHPNADKLYVLKVDIGEEKPRQIVSGAANVyppeeLVGKKVVVAVN---------LKPKKLRGVESEGMLLSAEELGL 79
|
90 100
....*....|....*....|
gi 495776075 128 SDDHNGIIELPLDAPIGTDI 147
Cdd:cd02153 80 EEGSVGILELPEDAPVGDRI 99
|
|
| B5 |
smart00874 |
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits. |
404-471 |
7.73e-28 |
|
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
Pssm-ID: 197942 [Multi-domain] Cd Length: 68 Bit Score: 106.81 E-value: 7.73e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495776075 404 ATITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTEGQDEWKAVAPSWRFDMEIEEDLVEEVARVYGY 471
Cdd:smart00874 1 RTITLRLERINRLLGLEILAEEIEEILKRLGFEVEVSGDTLEVTVPSYRFDILIEADLIEEVARIYGY 68
|
|
| tRNA_bind |
pfam01588 |
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ... |
53-146 |
3.99e-24 |
|
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.
Pssm-ID: 396251 [Multi-domain] Cd Length: 96 Bit Score: 96.93 E-value: 3.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 53 CGQHPNADKLRVTKVNVGGDRLLDIVCGAPNCRQGLKVaVATVGAVLPgdfKIKAAKLRGEPSEGMLCSFSELGISDDhn 132
Cdd:pfam01588 9 AERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEEL-VGRLVVVVA---NLKPAKLRGVESEGMILSAEELDGGSV-- 82
|
90
....*....|....
gi 495776075 133 GIIELPLDAPIGTD 146
Cdd:pfam01588 83 GLLEPPADVPPGTK 96
|
|
| B5 |
pfam03484 |
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits. |
406-471 |
8.91e-24 |
|
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
Pssm-ID: 460942 [Multi-domain] Cd Length: 67 Bit Score: 95.15 E-value: 8.91e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495776075 406 ITLRRSKLDRLIGHHVADAQVTDILKRLGCDVTE-GQDEWKAVAPSWRFDMEIEEDLVEEVARVYGY 471
Cdd:pfam03484 1 ITLRLDRINRLLGIDLSAEEIVEILERLGFEVEEeDGDTLTVTVPSYRPDILHEADLIEEVARIYGY 67
|
|
| PLN02265 |
PLN02265 |
probable phenylalanyl-tRNA synthetase beta chain |
391-685 |
3.99e-15 |
|
probable phenylalanyl-tRNA synthetase beta chain
Pssm-ID: 215149 [Multi-domain] Cd Length: 597 Bit Score: 79.34 E-value: 3.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 391 VIDVTNEATL-PKRAT--ITLRRSKLDRLIGHHVADAQVTDILKR--LGCDVT-EGQDEWKAVAPSWRFDMEIEEDLVEE 464
Cdd:PLN02265 294 VVYPDGKSTVyPDLSVrtMEVDLSYINSSIGVSLDAEEVASLLNKmqLQAEQSsDDGCTIRVSVPPTRSDILHPCDVAED 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 465 VARVYGYNNIPDEPVQAGLVMGTHREADLS-LKRVKTMLNdkGYQEVITYSFV--DPKLQQLIHP--GQEALILPSPISS 539
Cdd:PLN02265 374 VAIAYGYNNIPKRKPKSMTVGKQQPLNQFSdLLRAEVAMA--GFTEVLTWILCshKENFAMLNREddGNSAVIIGNPRSA 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 540 EMSAMRLSLWTGLLGTIVYNQNRQQNrVRIFESGLRFVPDNQANLGIRQDLMLA----GAISGnryeehwdlakgtvdFY 615
Cdd:PLN02265 452 DFEVVRTSLLPGLLKTLGHNKDAPKP-IKLFEVSDVVLLDESKDVGARNSRRLAalycGTTSG---------------FE 515
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495776075 616 DMKGDLEAILDLTG-------KLSEIEFRAEAIPALHPGQSAALYLDGKRIGFIGVVHPELERKLDLNGRTIVFELE 685
Cdd:PLN02265 516 VIHGLVDRIMEVLGipfveigDNNGYYVEPSNEPEYFPGRQASIIYKGKHVGTFGIVHPEVLNNFDIPDPCSFLELD 592
|
|
| B3/B4 |
COG3382 |
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ... |
238-388 |
7.25e-11 |
|
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];
Pssm-ID: 442609 [Multi-domain] Cd Length: 233 Bit Score: 62.95 E-value: 7.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 238 LRRCGIRSIDAVVDVTNYVLLELGQPMHAFDKDRIEGGIVVRMAKEGETLVLLDGTEAKLNADTLVI-ADhskalaMGGI 316
Cdd:COG3382 90 LKGGGLPRINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGDEEEPPEPGEVVyAD------DEGV 163
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495776075 317 FG-------GEHSGVNDETQNVLLECAFFSPLSitgrarrhglhtdashryergvDPALQyKAMERATRLLIDICGGEA 388
Cdd:COG3382 164 FCrrwpwrdSERTKVTEETKNALFIIEGLPGVS----------------------AEDLE-AALDELAELLERYLGGEV 219
|
|
| tRNA_bind_EMAP-II_like |
cd02799 |
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ... |
53-147 |
1.99e-07 |
|
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.
Pssm-ID: 239198 [Multi-domain] Cd Length: 105 Bit Score: 49.92 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 53 CGQHPNADKLRVTKVNVGGDRLLDIVCG-----APNCRQGLKVAVATvgavlpgdfKIKAAKLRGEPSEGM-LCsfselG 126
Cdd:cd02799 16 VRKHPDADSLYVEEIDLGEEEPRTIVSGlvkfvPLEQMQNRLVVVLC---------NLKPRKMRGVKSQGMvLC-----A 81
|
90 100
....*....|....*....|...
gi 495776075 127 ISDDHNG--IIELPLDAPIGTDI 147
Cdd:cd02799 82 SNADHEKveLLEPPEGAKPGERV 104
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
53-148 |
2.40e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 41.32 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776075 53 CGQHPNADKLRVTKVNVGGDRLLDIVCG-----APNCRQGLKVAVATvgavlpgdfKIKAAKLRGEPSEGMLcsfseLGI 127
Cdd:PRK12267 561 AEKVEKSDKLLKLQVDLGEEEPRQIVSGiakfyPPEELVGKKVVVVA---------NLKPAKLMGEESQGMI-----LAA 626
|
90 100
....*....|....*....|..
gi 495776075 128 SDDHN-GIIELPLDAPIGTDIR 148
Cdd:PRK12267 627 EDDGKlTLLTVDKEVPNGSKVK 648
|
|
| |
