NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|495776180|ref|WP_008500759|]
View 

MULTISPECIES: two-component system sensor histidine kinase PhoQ [Enterobacter]

Protein Classification

two-component system sensor histidine kinase PhoQ( domain architecture ID 11484966)

two-component system sensor histidine kinase PhoQ is a member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
5-486 0e+00

two-component system sensor histidine kinase PhoQ;


:

Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 1011.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   5 LRHLLPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQQSPT 84
Cdd:PRK10815   3 LRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNSPT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  85 LALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAETEMTHSVAINLY 164
Cdd:PRK10815  83 LVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVNVY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 165 PATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLNPETT 244
Cdd:PRK10815 163 PATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPNPP 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 245 RELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSK-LSVDDAEPVMLEQISRISQQIGYYLH 323
Cdd:PRK10815 243 RELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYYLH 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 324 RASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSA 403
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 404 RQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQQPT 483
Cdd:PRK10815 403 RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHST 482

                 ...
gi 495776180 484 SND 486
Cdd:PRK10815 483 PKD 485
 
Name Accession Description Interval E-value
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
5-486 0e+00

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 1011.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   5 LRHLLPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQQSPT 84
Cdd:PRK10815   3 LRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNSPT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  85 LALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAETEMTHSVAINLY 164
Cdd:PRK10815  83 LVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVNVY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 165 PATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLNPETT 244
Cdd:PRK10815 163 PATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPNPP 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 245 RELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSK-LSVDDAEPVMLEQISRISQQIGYYLH 323
Cdd:PRK10815 243 RELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYYLH 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 324 RASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSA 403
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 404 RQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQQPT 483
Cdd:PRK10815 403 RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHST 482

                 ...
gi 495776180 484 SND 486
Cdd:PRK10815 483 PKD 485
PhoQ_Sensor pfam08918
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria ...
10-189 1.83e-105

PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognizes divalent metal cations, and antimicrobial cationic peptides (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 430316  Cd Length: 179  Bit Score: 311.59  E-value: 1.83e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   10 PLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQQSPTLALIY 89
Cdd:pfam08918   1 PFSLRTRFLLATAAVVLALSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYSLAQWDDNKLTIAVPPNLDLNSPTLVLIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   90 NEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAeTEMTHSVAINLYPATLN 169
Cdd:pfam08918  81 DENGKLLWRQRHVPELEKHIKPEWLKKNGFYELDTDTDTSSALLGNNPLAQDQLKAINDDDD-NELTHSVAVNRYPATSR 159
                         170       180
                  ....*....|....*....|
gi 495776180  170 MPQLTIVVIDTIPVELKRSY 189
Cdd:pfam08918 160 LPALTIVVVDTIPQELQRSD 179
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
343-477 6.31e-80

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 244.85  E-value: 6.31e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPGIP 422
Cdd:cd16954    1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVP 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495776180 423 RNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16954   81 ESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
159-477 1.04e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 143.51  E-value: 1.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 159 VAINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREK 238
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 239 LNPETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSkLSVDDAEPV--MLEQISRISQ 316
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLetILRSADRLLR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 317 QIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYC 395
Cdd:COG0642  160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYT 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 396 LE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGV--GLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:COG0642  240 PEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGT 319

                 ....*.
gi 495776180 472 RMEVIF 477
Cdd:COG0642  320 TFTVTL 325
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
375-477 9.58e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 101.19  E-value: 9.58e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   375 GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRAD---TLRPGQGVGLAV 449
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
                           90       100
                   ....*....|....*....|....*...
gi 495776180   450 AREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITL 108
 
Name Accession Description Interval E-value
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
5-486 0e+00

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 1011.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   5 LRHLLPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQQSPT 84
Cdd:PRK10815   3 LRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNSPT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  85 LALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAETEMTHSVAINLY 164
Cdd:PRK10815  83 LVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVNVY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 165 PATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLNPETT 244
Cdd:PRK10815 163 PATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPNPP 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 245 RELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSK-LSVDDAEPVMLEQISRISQQIGYYLH 323
Cdd:PRK10815 243 RELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYYLH 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 324 RASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSA 403
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 404 RQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQQPT 483
Cdd:PRK10815 403 RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHST 482

                 ...
gi 495776180 484 SND 486
Cdd:PRK10815 483 PKD 485
PhoQ_Sensor pfam08918
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria ...
10-189 1.83e-105

PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognizes divalent metal cations, and antimicrobial cationic peptides (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 430316  Cd Length: 179  Bit Score: 311.59  E-value: 1.83e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   10 PLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQQSPTLALIY 89
Cdd:pfam08918   1 PFSLRTRFLLATAAVVLALSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYSLAQWDDNKLTIAVPPNLDLNSPTLVLIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   90 NEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAeTEMTHSVAINLYPATLN 169
Cdd:pfam08918  81 DENGKLLWRQRHVPELEKHIKPEWLKKNGFYELDTDTDTSSALLGNNPLAQDQLKAINDDDD-NELTHSVAVNRYPATSR 159
                         170       180
                  ....*....|....*....|
gi 495776180  170 MPQLTIVVIDTIPVELKRSY 189
Cdd:pfam08918 160 LPALTIVVVDTIPQELQRSD 179
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
343-477 6.31e-80

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 244.85  E-value: 6.31e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPGIP 422
Cdd:cd16954    1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVP 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495776180 423 RNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16954   81 ESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
159-477 1.04e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 143.51  E-value: 1.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 159 VAINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREK 238
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 239 LNPETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSkLSVDDAEPV--MLEQISRISQ 316
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLetILRSADRLLR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 317 QIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYC 395
Cdd:COG0642  160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYT 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 396 LE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGV--GLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:COG0642  240 PEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGT 319

                 ....*.
gi 495776180 472 RMEVIF 477
Cdd:COG0642  320 TFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
250-477 2.63e-38

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 139.66  E-value: 2.63e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 250 LVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEPVMLEQIS----RISQQIGYYLHRA 325
Cdd:COG2205    2 LEEALEELEELERLK----SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIResaeRLLRLIEDLLDLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 326 SMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPE-ISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVS 402
Cdd:COG2205   78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPggTITIS 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495776180 403 ARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG2205  158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
160-477 3.44e-34

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 132.37  E-value: 3.44e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 160 AINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKL 239
Cdd:COG5002   53 ALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLG 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 240 NPETTRELTSLVRNLNRLLK---SERERYDKYRTTLT-DLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEP----VMLEQI 311
Cdd:COG5002  133 RLSLRLSALLLGLLLLAAVErdiTELERLEQMRREFVaNVSHELRTPLTSIRGYLELLLDGAADDPEERReyleIILEEA 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 312 SRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDN 390
Cdd:COG5002  213 ERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlGDPDRLEQVLTNLLDN 292
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 391 ACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYDGKIETS 464
Cdd:COG5002  293 AIKYTPEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRsretGGTGLGLAIVKHIVEAHGGRIWVE 372
                        330
                 ....*....|...
gi 495776180 465 ESLLGGARMEVIF 477
Cdd:COG5002  373 SEPGKGTTFTITL 385
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
375-477 9.58e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 101.19  E-value: 9.58e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   375 GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRAD---TLRPGQGVGLAV 449
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
                           90       100
                   ....*....|....*....|....*...
gi 495776180   450 AREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
380-477 2.12e-24

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 97.29  E-value: 2.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 380 FMEVMGNLLDNACKYCLEF--VEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVD 455
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPGgtIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRegGGTGLGLAIVRRIVE 80
                         90       100
                 ....*....|....*....|..
gi 495776180 456 QYDGKIETSESLLGGARMEVIF 477
Cdd:cd00075   81 AHGGRITVESEPGGGTTFTVTL 102
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
193-477 1.62e-21

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 97.01  E-value: 1.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 193 SWFIYVLAAnlLLVIPLLWIAAWWSLRPIESLakevreLEEHHREKLNPETTR-------ELTSLVRNLNRLL----KSE 261
Cdd:PRK10549 166 SWLIVALST--LLAALATFLLARGLLAPVKRL------VEGTHKLAAGDFTTRvtptsrdELGRLAQDFNQLAstleKNE 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 262 RERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRssklsvDDAEPVMLEQISRISQQIGYY------LHRASMRSGSALLS 335
Cdd:PRK10549 238 QMR----RDFMADISHELRTPLAVLRGELEAIQ------DGVRKFTPESVASLQAEVGTLtklvddLHQLSLSDEGALAY 307
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 336 RELH-PVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTDNELHI 412
Cdd:PRK10549 308 RKTPvDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRL 387
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495776180 413 IVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:PRK10549 388 TFADSAPGVSDEQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
375-477 9.25e-21

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 87.04  E-value: 9.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  375 GEKNDFMEVMGNLLDNACKYCLEFVEVSAR-QTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR-PGQGVGLAVARE 452
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLGLSIVRK 80
                          90       100
                  ....*....|....*....|....*
gi 495776180  453 IVDQYDGKIETSESLLGGARMEVIF 477
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTL 105
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
343-477 3.22e-20

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 92.22  E-value: 3.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEK-NDFMEVMGNLLDNACKYCLE------FVEVSARQTDNELHIIVE 415
Cdd:COG3290  244 PVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSdTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVE 323
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495776180 416 DDGPGIPRNKRDVVFDRGQRadT-LRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG3290  324 DSGPGIPEELLEKIFERGFS--TkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
PRK10490 PRK10490
sensor protein KdpD; Provisional
236-482 4.25e-20

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 93.95  E-value: 4.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 236 REKLNPETTREL---TSLVRN-LNRL----------LKSERERYdkyRTTL-TDLTHSLKTPLAVMqstlrsmrssklsV 300
Cdd:PRK10490 620 RQLMIPEQQRLLetfTLLIANaLERLtltaseeqarLASEREQL---RNALlAALSHDLRTPLTVL-------------F 683
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 301 DDAEPVML----------EQISRISQQI-------GYYLHRASMRSGSALLSRELHPvaplLDNLT-SALNKV-YQRKGV 361
Cdd:PRK10490 684 GQAEILTLdlasegsphaRQASEIRQQVlnttrlvNNLLDMARIQSGGFNLRKEWLT----LEEVVgSALQMLePGLSGH 759
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 362 NISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVE--VSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRAD- 437
Cdd:PRK10490 760 PINLSLPEPLTLIHVDGPLFErVLINLLENAVKYAGAQAEigIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNk 839
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 495776180 438 -TLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQQP 482
Cdd:PRK10490 840 eSAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETP 885
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
200-477 5.82e-20

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 91.95  E-value: 5.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 200 AANLLLVIPL--LWIAAWWSLRPIESLAKEVRE-LEEHHREKLNPETTRELTSLVR--------------NLNRLLKSER 262
Cdd:COG5000  118 AAERLLGIPLeeLIGKPLEELLPELDLAELLREaLERGWQEEIELTRDGRRTLLVRasplrddgyvivfdDITELLRAER 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 263 erydkyRTTLTD----LTHSLKTPLAVMQSTLRSMRS--SKLSVDDAEP------VMLEQISRISQQIGYYLHRASMRSg 330
Cdd:COG5000  198 ------LAAWGElarrIAHEIKNPLTPIQLSAERLRRklADKLEEDREDleraldTIIRQVDRLKRIVDEFLDFARLPE- 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 331 salLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTD 407
Cdd:COG5000  271 ---PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKNAIEAIEEggEIEVSTRRED 347
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495776180 408 NELHIIVEDDGPGIPRNKRDVVFDrgqradtlrP-------GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG5000  348 GRVRIEVSDNGPGIPEEVLERIFE---------PffttkpkGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
191-472 2.11e-19

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 90.67  E-value: 2.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 191 VWSWFIYVLAANLLLVIpllwIAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLlkseRERYD---- 266
Cdd:PRK11100 184 ILWAGALLLGIALLIGA----GVVWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELAQALESM----RVKLEgkay 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 267 --KYRTTLTdltHSLKTPLAVMQSTLRSMRSSkLSVDDAEPVM---LEQISRISQQIGYYLHRASMRSGSALLSRELHPV 341
Cdd:PRK11100 256 veQYVQTLT---HELKSPLAAIRGAAELLQED-PPPEDRARFTgniLTQSARLQQLIDRLLELARLEQRQELEVLEPVAL 331
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 342 APLLDNLTSALNKVYQRKGVNISLDIsPEISFVGEKNDFMEVMGNLLDNAckycLEF------VEVSARQTDNELHIIVE 415
Cdd:PRK11100 332 AALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNA----IDFspeggtITLSAEVDGEQVALSVE 406
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 416 DDGPGIPRNKRDVVFDRG---QRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK11100 407 DQGPGIPDYALPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
384-476 2.41e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 83.14  E-value: 2.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 384 MGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYDG 459
Cdd:cd16949    5 LENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHGG 84
                         90
                 ....*....|....*..
gi 495776180 460 KIETSESLLGGARMEVI 476
Cdd:cd16949   85 KIKASNRKPGGLRVRIW 101
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
383-472 2.31e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 80.17  E-value: 2.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYD 458
Cdd:cd16939    4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRdratGGFGLGLAIVHRVALWHG 83
                         90
                 ....*....|....
gi 495776180 459 GKIETSESLLGGAR 472
Cdd:cd16939   84 GHVECDDSELGGAC 97
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
1-482 8.03e-18

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 85.99  E-value: 8.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   1 MRRILRHLLPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQ 80
Cdd:COG4251   22 LLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  81 QSPTLALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAETEMTHSVA 160
Cdd:COG4251  102 LLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 161 INLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLN 240
Cdd:COG4251  182 LLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLEL 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 241 PETTRELTSLVRNLNRllkSERErydkyrttLTDLTHS----LKTPLAVMQS---TLRSMRSSKLSvDDAepvmLEQISR 313
Cdd:COG4251  262 EELEEELEERTAELER---SNEE--------LEQFAYVashdLREPLRKISGfsqLLEEDYGDKLD-EEG----REYLER 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 314 ISQQIgyylHRASM---------RSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEIsfVGEKNDFMEVM 384
Cdd:COG4251  326 IRDAA----ERMQAliddllaysRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTV--RGDPTLLRQVF 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 385 GNLLDNACKYCLE----FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQR--ADTLRPGQGVGLAVAREIVDQYD 458
Cdd:COG4251  400 QNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVERHG 479
                        490       500
                 ....*....|....*....|....*
gi 495776180 459 GKIeTSESLLG-GARMEVIFGRQQP 482
Cdd:COG4251  480 GRI-WVESEPGeGATFYFTLPKAPA 503
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
199-475 1.53e-17

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 84.98  E-value: 1.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 199 LAANLLLVIPLLWIAAWwslrpieSLAKEVRELEEHHRE------KLNPET---TRELTSLVRNLNRLLKSERERYDKYR 269
Cdd:PRK09470 172 LLVTMLVSTPLLLWLAW-------SLAKPARKLKNAADEvaqgnlRQHPELetgPQEFRQAGASFNQMVTALERMMTSQQ 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 270 TTLTDLTHSLKTPLAVMQSTLRSMR-----SSKLSVDDAEpvmleqISRISQQIGYYLHRASMRSGSALlSRELHPVAPL 344
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRrrqgeSKELERIETE------AQRLDSMINDLLVLSRNQQKNHL-ERETFKANSL 317
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 345 LDN-LTSALNKVYQRkgvNISLDIS--PEISFV-GEKNDFMEVMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPG 420
Cdd:PRK09470 318 WSEvLEDAKFEAEQM---GKSLTVSapPGPWPInGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPG 394
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495776180 421 IPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGARMEV 475
Cdd:PRK09470 395 VPEEEREQIFRPFYRVDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTI 453
PRK10604 PRK10604
sensor protein RstB; Provisional
190-472 2.06e-16

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 81.19  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 190 MVWSWFIYVLAANLLLVIP-LLWIAAWW-SLRPIESLAKEVRE--LEEhhREKLNPETtreltSLVR----------NLN 255
Cdd:PRK10604 134 MRLLDIALLALIGLSLAFPvFLWMRPHWqDMLKLEAAAQRLGDghLAE--RIHFDEGS-----SLERlgvafnqmadNIN 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 256 RLLKSererydkyRTTLTD-LTHSLKTPLAVMQSTLrSMrSSKLSvdDAEPVMLEQ-ISRISQQIGYYLHRASmrsgsal 333
Cdd:PRK10604 207 ALIAS--------KKQLIDgIAHELRTPLVRLRYRL-EM-SDNLS--AAESQALNRdIGQLEALIEELLTYAR------- 267
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 334 LSR---ELHPVAPLLDN-LTSALNKVYQ-RKGVNISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVEVSARQTD 407
Cdd:PRK10604 268 LDRpqnELHLSEPDLPAwLSTHLADIQAvTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLLLDG 347
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495776180 408 NELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK10604 348 NQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGAR 416
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
380-477 3.77e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 74.04  E-value: 3.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 380 FMEVMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREI 453
Cdd:cd16946    5 LQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAICHNI 84
                         90       100
                 ....*....|....*....|....
gi 495776180 454 VDQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16946   85 ALAHGGTISAEHSPLGGLRLVLTL 108
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
196-477 9.82e-16

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 78.69  E-value: 9.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 196 IYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLLKSERERydkyRTTLTDL 275
Cdd:COG4191   58 LLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEEL----RELQEQL 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 276 THS----------------LKTPLAVMQSTLRSMRSSKLSVDDAEPV------MLEQISRISQQIgyylhrASMRSGSAL 333
Cdd:COG4191  134 VQSeklaalgelaagiaheINNPLAAILGNAELLRRRLEDEPDPEELrealerILEGAERAAEIV------RSLRAFSRR 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 334 LSRELHPV--APLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACkYCLE-----FVEVSARQ 405
Cdd:COG4191  208 DEEEREPVdlNELIDEALELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAI-DAMEegeggRITISTRR 286
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495776180 406 TDNELHIIVEDDGPGIPRNKRDVVFD-------RGQradtlrpGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG4191  287 EGDYVVISVRDNGPGIPPEVLERIFEpffttkpVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
113-477 1.79e-15

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 78.52  E-value: 1.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 113 WLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAETEMTHSVAINLYPATLNMPQLTIVVIDTIPVELKRSYMVW 192
Cdd:COG2972   77 LALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLR 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 193 SWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLLkserERYDKYRTTL 272
Cdd:COG2972  157 RLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMV----ERIKELIEEV 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 273 TDLTHSLK-TPLAVMQS---------TLRSMRSSKLSVDDaepvmlEQISRISQQIGYYLhRASMRSGSAL--LSRELHP 340
Cdd:COG2972  233 YELELEKKeAELKALQAqinphflfnTLNSIRWLAELEDP------EEAEEMLEALSKLL-RYSLSKGDELvtLEEELEL 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 341 VAPLLdnltsALNKVYQRKGVNISLDISPEIsfvgekndfMEVM------GNLLDNACKYCLE------FVEVSARQTDN 408
Cdd:COG2972  306 IKSYL-----EIQKLRFGDRLEVEIEIDEEL---------LDLLipklilQPLVENAIEHGIEpkegggTIRISIRKEGD 371
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495776180 409 ELHIIVEDDGPGIPRNKRDVVFdrgQRADTLRPGQGVGLAVAREIVDQYDGK---IETSESLLGGARMEVIF 477
Cdd:COG2972  372 RLVITVEDNGVGMPEEKLEKLL---EELSSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRI 440
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
383-475 6.53e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 70.39  E-value: 6.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLEF------VEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRG--QRADTLRpgqGVGLAVAREIV 454
Cdd:cd16915    4 IVGNLIDNALDALAATgapnkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGvsTKGQGER---GIGLALVRQSV 80
                         90       100
                 ....*....|....*....|.
gi 495776180 455 DQYDGKIETSESLLGGARMEV 475
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSI 101
envZ PRK09467
osmolarity sensor protein; Provisional
204-477 1.78e-14

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 75.33  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 204 LLVIPLLWIA-AWWSLR----PIESL---AKEVRELEehHREKLNPETTRELTSLVRNLNRLLKSERERYDKyRTTLT-D 274
Cdd:PRK09467 159 TLAIGLLSVAgGWLFIRiqnrPLVALehaALQVGKGE--IPPPLREYGASEVRSVTRAFNQMAAGIKQLEDD-RTLLMaG 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 275 LTHSLKTPLavmqsTLRSMRSSKLSVDDAepVMLEQISR--------ISQQIGYylhrasMRSGSALlSRELHPVAPLLD 346
Cdd:PRK09467 236 VSHDLRTPL-----TRIRLATEMMSEEDG--YLAESINKdieecnaiIEQFIDY------LRTGQEM-PMEMADLNALLG 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 347 NLTSALNKvYQRKgvnISLDISPeisfvGEKNDFME------VMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPG 420
Cdd:PRK09467 302 EVIAAESG-YERE---IETALQP-----GPIEVPMNpiaikrALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPG 372
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495776180 421 IPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:PRK09467 373 IPPEQLKHLFQPFTRGDSARgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
383-474 3.30e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 68.24  E-value: 3.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGK 460
Cdd:cd16950    4 VLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARgtSGTGLGLAIVQRISDAHGGS 83
                         90
                 ....*....|....*.
gi 495776180 461 IETSESLLGG--ARME 474
Cdd:cd16950   84 LTLANRAGGGlcARIE 99
PRK09303 PRK09303
histidine kinase;
228-461 3.30e-12

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 68.05  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 228 VRELEEHHREKlNPETTRELTSLVRNLNRL--LKSERErydkyrtTLTD-----------LTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK09303 106 YSGLGENLQPS-EIDSGRYSQELLQLSDELfvLRQENE-------TLLEqlkfkdrvlamLAHDLRTPLTAASLALETLE 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 295 S-SKLSVDDAEPVMLEQ-----------ISRISQQIgyyLHRASMRSgSALlsrELHPV----APLLDNLTSALNKVYQR 358
Cdd:PRK09303 178 LgQIDEDTELKPALIEQlqdqarrqleeIERLITDL---LEVGRTRW-EAL---RFNPQkldlGSLCQEVILELEKRWLA 250
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 359 KGVNISLDISPEISFVGEKNDFM-EVMGNLLDNACKYCLE--FVEVSA-RQTDNELHIIVEDDGPGIPRNKRDVVFD--- 431
Cdd:PRK09303 251 KSLEIQTDIPSDLPSVYADQERIrQVLLNLLDNAIKYTPEggTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIFEdrv 330
                        250       260       270
                 ....*....|....*....|....*....|
gi 495776180 432 RGQRADTlRPGQGVGLAVAREIVDQYDGKI 461
Cdd:PRK09303 331 RLPRDEG-TEGYGIGLSVCRRIVRVHYGQI 359
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
382-475 5.62e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 62.42  E-value: 5.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 382 EVMGNLLDNACKYCLE----FVEVSARQTDNelhIIVEDDGPGIPRNKRDVVFDRGQRAD-TLRPGQGVGLAVAREIVDQ 456
Cdd:cd16940   16 LLLRNLVDNAVRYSPQgsrvEIKLSADDGAV---IRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVKRIVEL 92
                         90
                 ....*....|....*....
gi 495776180 457 YDGKIETSESLLGGARMEV 475
Cdd:cd16940   93 HGGQIFLGNAQGGGLEAWV 111
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
381-470 5.88e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 61.96  E-value: 5.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 381 MEVMGNLLDNACKYCLEF----VEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIV 454
Cdd:cd16921    2 GQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVRKII 81
                         90
                 ....*....|....*.
gi 495776180 455 DQYDGKIeTSESLLGG 470
Cdd:cd16921   82 ERHGGRI-WLESEPGE 96
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
150-467 3.39e-11

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 65.18  E-value: 3.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 150 DAETEMTHS----VAINLYPATLNMPQLTIVVIDTIPV------ELKRSYMVWSWFIYvlaanlLLVIPLLWIAAWWSLR 219
Cdd:PRK09835 138 HGHGHMEHSnwrmIALPVGPLVDGKPIYTLLIALSIDFhlhyinDLKNKLIMTASVIS------LLIVFIVLLAVHKGHA 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 220 PIESLAKEVREL-EEHHREKLNPETTR-ELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLA--VMQS--TLRSM 293
Cdd:PRK09835 212 PIRSVSRQIQNItSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlITQTeiALSQS 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 294 RSSKlsvdDAEPVM---LEQISRISQQIGYYLHRASMRSgsallsRELHPVAPLLDnLTSALNKVY-------QRKGVNI 363
Cdd:PRK09835 292 RSQK----ELEDVLysnLEELTRMAKMVSDMLFLAQADN------NQLIPEKKMLD-LADEVGKVFdffeawaEERGVEL 360
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 364 SLDISPeISFVGEKNDFMEVMGNLLDNACKYCL--EFVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR- 440
Cdd:PRK09835 361 RFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPagEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRq 439
                        330       340       350
                 ....*....|....*....|....*....|
gi 495776180 441 ---PGQGVGLAVAREIVDQYDGKIETSESL 467
Cdd:PRK09835 440 rkgEGSGIGLAIVKSIVVAHKGTVAVTSDA 469
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
199-460 4.88e-11

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 64.22  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 199 LAANLLLVIPLLWIAAW---WSLRPIESLAKEvreLEEHHREKLNP----ETTRELTSLVRNLNRLLKSERERYDKYRTT 271
Cdd:PRK10755  64 LVPSLVMVSLTLLICFQavrWITRPLAELQKE---LEARTADNLTPiaihSSTLEIEAVTSALNQLVSRLTSTLDQERLF 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 272 LTDLTHSLKTPLAVMQSTLRSMrsSKLSVDDAEPvMLEQISRISQQIGYYLHRAsmRSGSALLSRELHPVApLLDN---- 347
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLELL--EKQHHIDVAP-LIARLDQMMHTVEQLLQLA--RAGQSFSSGHYQTVK-LLEDvilp 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 348 LTSALNKVYQRKGVNISLDISP-EISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRN 424
Cdd:PRK10755 215 SQDELSEMLEQRQQTLLLPESAaDITVQGDATLLRLLLRNLVENAHRYSPEgsTITIKLSQEDGGAVLAVEDEGPGIDES 294
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 495776180 425 KRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGK 460
Cdd:PRK10755 295 KCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQ 330
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
382-461 3.03e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 57.58  E-value: 3.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 382 EVMGNLLDNACKYCLEF---VEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDR--GQRADTLRPGQ--GVGLAVAREIV 454
Cdd:cd16953    3 QVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRfyTERPANEAFGQhsGLGLSISRQII 82

                 ....*..
gi 495776180 455 DQYDGKI 461
Cdd:cd16953   83 EAHGGIS 89
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
233-472 3.68e-10

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 61.95  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 233 EHHRE-KLNPETTRELTSLVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLS---VDDAEPVML 308
Cdd:PRK11006 172 GRHLEiRVMPYTEGQLLMVARDVTQMHQLEGAR----RNFFANVSHELRTPLTVLQGYLEMMQDQPLEgalREKALHTMR 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 309 EQISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGvNISLDISPEISFVGEKNDFMEVMGNLL 388
Cdd:PRK11006 248 EQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKH-TITFEVDNSLKVFGNEDQLRSAISNLV 326
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 389 DNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIE 462
Cdd:PRK11006 327 YNAVNHTPEgtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqtgGSGLGLAIVKHALSHHDSRLE 406
                        250
                 ....*....|
gi 495776180 463 TSESLLGGAR 472
Cdd:PRK11006 407 IESEVGKGTR 416
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
219-472 5.74e-10

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 61.84  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 219 RPIESLAKEVRELEeHHREKLNPET---TRELTSLVRNlNRLLKSERERYDKYRTT-LTDLTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK11466 393 RLMDAFRSNVHALN-RHREQLAAQVkarTAELQELVIE-HRQARAEAEKASQAKSAfLAAMSHEIRTPLYGILGTAQLLA 470
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 295 SSKLS---------VDDAEPVMLEQISRIsqqigyyLHRASMRSGSALLSRELHPVAP--LLDNLTSALNKVYQRKGVNI 363
Cdd:PRK11466 471 DNPALnaqrddlraITDSGESLLTILNDI-------LDYSAIEAGGKNVSVSDEPFEPrpLLESTLQLMSGRVKGRPIRL 543
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 364 SLDISPEI--SFVGEKNDFMEVMGNLLDNACKYCLE-FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR 440
Cdd:PRK11466 544 ATDIADDLptALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR 623
                        250       260       270
                 ....*....|....*....|....*....|..
gi 495776180 441 PGQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK11466 624 GGTGLGLTISSRLAQAMGGELSATSTPEVGSC 655
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
362-469 6.91e-10

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 61.08  E-value: 6.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 362 NISLDIS-----PEISFVGEKNDFMEVMGNLLDNAckycLEFV--------EVSARQTDNELHIIVEDDGPGIPRNKRDV 428
Cdd:PRK11086 411 GITLIISedsqlPDSGDEDQVHELITILGNLIENA----LEAVggeeggeiSVSLHYRNGWLHCEVSDDGPGIAPDEIDA 486
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 495776180 429 VFDRGqrADTLRPGQGVGLAVAREIVDQYDGKIETsESLLG 469
Cdd:PRK11086 487 IFDKG--YSTKGSNRGVGLYLVKQSVENLGGSIAV-ESEPG 524
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
383-465 1.28e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 55.58  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLE---FVEVSARQTDNE---LHIIVEDDGPGIPRNKRDVVFDRGQRAD--TLRP--GQGVGLAVARE 452
Cdd:cd16922    4 ILLNLLGNAIKFTEEgevTLRVSLEEEEEDgvqLRFSVEDTGIGIPEEQQARLFEPFSQADssTTRKygGTGLGLAISKK 83
                         90
                 ....*....|....
gi 495776180 453 IVDQYDGKIE-TSE 465
Cdd:cd16922   84 LVELMGGDISvESE 97
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
384-462 1.34e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 55.54  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 384 MGNLLDNACKYCLEF--VEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRG---QRADTLRPGQGVGLAVAREIVDQYD 458
Cdd:cd16945    9 INNLLDNAIDFSPEGglIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQKSTGLGLAFVQEVAQLHG 88

                 ....
gi 495776180 459 GKIE 462
Cdd:cd16945   89 GRIT 92
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
383-462 1.68e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 55.09  E-value: 1.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYD 458
Cdd:cd16923    4 VFSNLLSNAIKYSPEntRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRntEGAGLGLSIAKAIIELHG 83

                 ....
gi 495776180 459 GKIE 462
Cdd:cd16923   84 GSAS 87
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
357-464 2.61e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 55.28  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 357 QRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLE------FVEVSARQTDNELHIIVEDDGPGIPRNKRDvvF 430
Cdd:cd16935   14 REKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKidkenrFIHLKIRQKKGFLIISIENSYEGELKKKNG--L 91
                         90       100       110
                 ....*....|....*....|....*....|....
gi 495776180 431 DRGQRADTLRpgqGVGLAVAREIVDQYDGKIETS 464
Cdd:cd16935   92 FLSTKKDKNH---GIGLKSIREIVKKYNGNLSIE 122
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
347-462 2.86e-09

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 58.70  E-value: 2.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 347 NLTSALNKVYQ------RKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACK------------YCLEFVEVSARQTD 407
Cdd:COG3852  205 NLHEVLERVLEllraeaPKNIRIVRDYDPSLPEVlGDPDQLIQVLLNLVRNAAEampeggtitirtRVERQVTLGGLRPR 284
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 408 NELHIIVEDDGPGIPRNKRDVVFD-----RGQradtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:COG3852  285 LYVRIEVIDNGPGIPEEILDRIFEpffttKEK-------GTGLGLAIVQKIVEQHGGTIE 337
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
277-462 6.12e-09

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 58.20  E-value: 6.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 277 HSLKTPLAVMQSTLRSMRSSKLSVDDAEPVMLEQISRISQQIGYYLHRASMRSGS---ALLSRELHPVAPLLdnLTSALN 353
Cdd:COG5805  296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNkekENINELIQDVVTLL--ETEAIL 373
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 354 KvyqrkGVNISLDISPEISFV-GEKNDFMEVMGNLLDNAckycLE------FVEVSARQTDNELHIIVEDDGPGIPRNkr 426
Cdd:COG5805  374 H-----NIQIRLELLDEDPFIyCDENQIKQVFINLIKNA----IEampnggTITIHTEEEDNSVIIRVIDEGIGIPEE-- 442
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 495776180 427 dvVFDR-GQRADTLR-PGQGVGLAVAREIVDQYDGKIE 462
Cdd:COG5805  443 --RLKKlGEPFFTTKeKGTGLGLMVSYKIIENHNGTID 478
PRK10337 PRK10337
sensor protein QseC; Provisional
199-453 7.60e-09

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 57.74  E-value: 7.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 199 LAANLLLVIPLLWIAaWWSLRPIESLAKEVRELEEHHREKLNPETT-RELTSLVRNLNRLLKS-----ERERydkyRTTl 272
Cdd:PRK10337 168 LVALPIMLIILMVLL-GRELAPLKKLALALRMRDPDSETPLNATGVpSEVRPLVEALNQLFARthammVRER----RFT- 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 273 TDLTHSLKTPLAVM--QSTLrsmrsSKLSVDDaePVMLEQ--------ISRISQQIGYYLHRASMRSGSALlsRELHPVa 342
Cdd:PRK10337 242 SDAAHELRSPLAALkvQTEV-----AQLSDDD--PQARKKallqlhagIDRATRLVDQLLTLSRLDSLDNL--QDVAEI- 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 343 PLLDNLTSALNKVY---QRKGVNISLDI-SPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTDNELHiiVEDDG 418
Cdd:PRK10337 312 PLEDLLQSAVMDIYhtaQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFT--VRDNG 389
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 495776180 419 PGIPRNKRDVVFDR-----GQRAdtlrPGQGVGLAVAREI 453
Cdd:PRK10337 390 PGVTPEALARIGERfyrppGQEA----TGSGLGLSIVRRI 425
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
382-476 2.13e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 52.04  E-value: 2.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 382 EVMGNLLDNACKYCLEFVEVSAR--QTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDG 459
Cdd:cd16943    6 QVLLNLLVNAAQAMEGRGRITIRtwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGG 85
                         90
                 ....*....|....*..
gi 495776180 460 KIETSESLLGGARMEVI 476
Cdd:cd16943   86 TIRVASVPGGGTRFTII 102
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
383-461 2.28e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.52  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQ 456
Cdd:cd16947   24 ILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITKRLAES 103

                 ....*
gi 495776180 457 YDGKI 461
Cdd:cd16947  104 MGGSI 108
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
383-475 2.45e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 52.11  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 383 VMGNLLDNACKYCLEFVEVSARQT---DNELHIIVEDDGPGIPRNKRDVVFDRGQRADTL----RPGQGVGLAVAREIVD 455
Cdd:cd16925    8 VVLNLLSNAFKFTPDGGRIRCILEkfrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSstraHGGTGLGLSIVKEFVE 87
                         90       100
                 ....*....|....*....|
gi 495776180 456 QYDGKIETSESLLGGARMEV 475
Cdd:cd16925   88 LHGGTVTVSDAPGGGALFQV 107
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
355-477 3.99e-08

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 55.74  E-value: 3.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 355 VYQRKGVNISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVEVSAR---QTDNELHIIVEDDGPGIPRNKRDVVF 430
Cdd:PRK11360 475 AGVQARVDFETELDNELPPIWADPELLKqVLLNILINAVQAISARGKIRIRtwqYSDGQVAVSIEDNGCGIDPELLKKIF 554
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 495776180 431 DRgqrADTLRP-GQGVGLAVAREIVDQYDGKIETsESLLG-GARMEVIF 477
Cdd:PRK11360 555 DP---FFTTKAkGTGLGLALSQRIINAHGGDIEV-ESEPGvGTTFTLYL 599
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
382-477 6.16e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 50.61  E-value: 6.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 382 EVMGNLLDNACKYC----LEFVEVSARQTDN---ELHIIVEDDGPGIPRNKRDVVFDrgQRADTLRPGQGVGLAVAREIV 454
Cdd:cd16944    7 QVLTNILKNAAEAIegrpSDVGEVRIRVEADqdgRIVLIVCDNGKGFPREMRHRATE--PYVTTRPKGTGLGLAIVKKIM 84
                         90       100
                 ....*....|....*....|...
gi 495776180 455 DQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16944   85 EEHGGRISLSNREAGGACIRIIL 107
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
386-481 1.22e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 49.89  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 386 NLLDNACKYCLEFVEVSAR--QTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDG 459
Cdd:cd16952    7 NLVSNAVKYTPPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHVMSRHDA 86
                         90       100
                 ....*....|....*....|..
gi 495776180 460 KIETSESLLGGARMEVIFGRQQ 481
Cdd:cd16952   87 RLLIASELGKGSRFTCLFPSSR 108
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
402-471 6.97e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 47.78  E-value: 6.97e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 402 SARQTDNELHIIVEDDGPGIPRNKRDVVFDrgQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:cd16920   30 TSPADDRAVTISVKDTGPGIAEEVAGQLFD--PFYTTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
410-462 1.11e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 47.01  E-value: 1.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495776180 410 LHIIVEDDGPGIPRNKRDVVFDR--GQRADtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:cd16918   44 LRVSVIDNGPGIPPDLQDTIFYPmvSGREN----GTGLGLAIAQNIVSQHGGVIE 94
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
378-464 1.34e-06

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 46.82  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  378 NDFMEVMGNLLDNA---CKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKrDVVFDRGQRADtlrpGQGVGLAVARE 452
Cdd:pfam14501   4 VDLCVIFGNLLDNAieaCSKIDDnrFIRLKIREKQNFLIIRIENTYEGELKFE-GKLPSTKTKGD----GHGIGLKSIRR 78
                          90
                  ....*....|..
gi 495776180  453 IVDQYDGKIETS 464
Cdd:pfam14501  79 IVKKYGGNLSTE 90
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
382-476 1.39e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 46.68  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 382 EVMGNLLDNACKYCLEF----VEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQY 457
Cdd:cd16976    3 QVLMNLLQNALDAMGKVenprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEH 82
                         90
                 ....*....|....*....
gi 495776180 458 DGKIETSESLLGGARMEVI 476
Cdd:cd16976   83 GGRLSVANEEGAGARFTFD 101
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
1-477 1.46e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 50.67  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180   1 MRRILRHLLPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWEDNRITVEMPENLNQ 80
Cdd:COG3920   14 AALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  81 QSPTLALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADDAETEMTHSVA 160
Cdd:COG3920   94 AAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLA 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 161 INLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREKLN 240
Cdd:COG3920  174 AAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRL 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 241 PETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSL--------------KTPLAVMQSTLRsMRSSKLSVDDAEPV 306
Cdd:COG3920  254 LLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLeekelllrelhhrvKNNLQVVSSLLR-LQARRADDPEAREA 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 307 MLEQISRIsqqigyylhrASMrsgsALLSRELH--------PVAPLLDNLTSALNKVYQRKGVNISLDIsPEISF----- 373
Cdd:COG3920  333 LEESQNRI----------QAL----ALVHELLYqsedwegvDLRDYLRELLEPLRDSYGGRGIRIELDG-PDVELpadaa 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 374 ------VGEkndfmevmgnLLDNACKYCLE-----FVEVSARQTDNELHIIVEDDGPGIPRNkrdvvFDRGQRadtlrpg 442
Cdd:COG3920  398 vplgliLNE----------LVTNALKHAFLsgeggRIRVSWRREDGRLRLTVSDNGVGLPED-----VDPPAR------- 455
                        490       500       510
                 ....*....|....*....|....*....|....*
gi 495776180 443 QGVGLAVAREIVDQYDGKIETSESllGGARMEVIF 477
Cdd:COG3920  456 KGLGLRLIRALVRQLGGTLELDRP--EGTRVRITF 488
glnL PRK11073
nitrogen regulation protein NR(II);
412-462 2.61e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 49.31  E-value: 2.61e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495776180 412 IIVEDDGPGIPRNKRDVVFD---RGQRAdtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:PRK11073 283 IDIEDNGPGIPPHLQDTLFYpmvSGREG-----GTGLGLSIARNLIDQHSGKIE 331
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
245-462 7.01e-06

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 48.43  E-value: 7.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 245 RELTSLVRNLNRLLKSERerYDKYRTTLTDLTHSLKTPLA-------VMQSTLRSMRSSKLSVddaepvMLEQISRISQQ 317
Cdd:COG5809  249 RDITERKKLEELLRKSEK--LSVVGELAAGIAHEIRNPLTslkgfiqLLKDTIDEEQKTYLDI------MLSELDRIESI 320
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 318 IGYYL-----HRASMRSGSalLSRELHPVAPLLDnlTSALnkvyqRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNA 391
Cdd:COG5809  321 ISEFLvlakpQAIKYEPKD--LNTLIEEVIPLLQ--PQAL-----LKNVQIELELEDDIPDIlGDENQLKQVFINLLKNA 391
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 392 ckycLEF------VEVSARQTDNELHII-VEDDGPGIPRNKRDVVFDrgqradtlrP-------GQGVGLAVAREIVDQY 457
Cdd:COG5809  392 ----IEAmpeggnITIETKAEDDDKVVIsVTDEGCGIPEERLKKLGE---------PfyttkekGTGLGLMVSYKIIEEH 458

                 ....*
gi 495776180 458 DGKIE 462
Cdd:COG5809  459 GGKIT 463
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
190-477 1.69e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 46.15  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 190 MVWSWFIYVLAANLLLVIPLLWIAAWWSLRPIESLAKEVRELEEHHREklnpetTREltslvrnlnrllkSERER----- 264
Cdd:COG4585    1 LLALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEE------ARE-------------EERRRiarel 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 265 YDkyrttltDLTHSLktplAVMQSTLRSMRSSKLSVDDAEPVMLEQISRISQQIGyylhrASMRSgsalLSRELHPVAPL 344
Cdd:COG4585   62 HD-------GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL-----AELRR----LVRGLRPPALD 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 345 LDNLTSAL----NKVYQRKGVNISLDISPEISFVGekndfMEVMGNL-------LDNACKYCL-EFVEVSARQTDNELHI 412
Cdd:COG4585  122 DLGLAAALeelaERLLRAAGIRVELDVDGDPDRLP-----PEVELALyrivqeaLTNALKHAGaTRVTVTLEVDDGELTL 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495776180 413 IVEDDGPGIPRNKrdvvfdrgqradtlRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG4585  197 TVRDDGVGFDPEA--------------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
PRK15347 PRK15347
two component system sensor kinase;
246-473 2.31e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 46.94  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 246 ELTSLVRNLNRLLKSERERYD------KYRTT-------------------LTDLTHSLKTPLAVMQSTLRSMRSSKLSV 300
Cdd:PRK15347 351 ELGSIAKAYNQLLDTLNEQYDtlenkvAERTQalaeakqraeqankrksehLTTISHEIRTPLNGVLGALELLQNTPLTA 430
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 301 DDAEPV---------MLEQI------SRIsqqigyylhrasmRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISL 365
Cdd:PRK15347 431 EQMDLAdtarqctlsLLAIInnlldfSRI-------------ESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRT 497
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 366 DISPEISFVGEKnDFMEV---MGNLLDNACKycleFVE-----VSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRAD 437
Cdd:PRK15347 498 FVGAHVPLYLHL-DSLRLrqiLVNLLGNAVK----FTEtggirLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD 572
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 495776180 438 TLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARM 473
Cdd:PRK15347 573 THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCF 608
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
376-461 2.99e-05

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 46.36  E-value: 2.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 376 EKNDFMEVMGNLLDNACKYCLE------FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQ-GVGLA 448
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASLRsdegnkIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIGLY 508
                         90
                 ....*....|...
gi 495776180 449 VAREIVDQYDGKI 461
Cdd:PRK15053 509 LIASYVTRCGGVI 521
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
272-461 3.76e-05

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 46.65  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDD-AEPVMLEQISRIS--QQIGYYLHRASMRSGSALLSRELHPVAPLLDNL 348
Cdd:PRK09959  716 LATMSHEIRTPISSIMGFLELLSGSGLSKEQrVEAISLAYATGQSllGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNT 795
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180  349 TSALNKVYQRKGVNISLDIS-PEISFVG-EKNDFMEVMGNLLDNACKYCLE---FVEVSARQTDNELHII---VEDDGPG 420
Cdd:PRK09959  796 CHSFGAIAASKSIALSCSSTfPDHYLVKiDPQAFKQVLSNLLSNALKFTTEgavKITTSLGHIDDNHAVIkmtIMDSGSG 875
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 495776180  421 IPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKI 461
Cdd:PRK09959  876 LSQEEQQQLFKRYSQTSAGRqqTGSGLGLMICKELIKNMQGDL 918
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
334-482 4.02e-05

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 46.21  E-value: 4.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 334 LSRELHPVAPLLdnltsalnKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTDNEL 410
Cdd:PRK13837 522 LSELVTEIAPLL--------RVSLPPGVELDFDQDQEPAVVeGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRAKLRA 593
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 411 H---------------IIVEDDGPGIPRNKRDVVFDRgqrADTLRP-GQGVGLAVAREIVDQYDGKIETSESLLGGARME 474
Cdd:PRK13837 594 PkvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEP---FFTTRAgGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFD 670

                 ....*...
gi 495776180 475 VIFGRQQP 482
Cdd:PRK13837 671 VYLPPSSK 678
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
387-458 4.55e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 42.98  E-value: 4.55e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495776180 387 LLDNACKYCLEF-----VEVSARQTDNELHIIVEDDGPGIPRNkrdvvfDRGQRADTLRPGqGVGLAVAREIVDQYD 458
Cdd:COG2172   42 AVTNAVRHAYGGdpdgpVEVELELDPDGLEIEVRDEGPGFDPE------DLPDPYSTLAEG-GRGLFLIRRLMDEVE 111
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
382-465 5.39e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 45.70  E-value: 5.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 382 EVMGNLLDNACKYCLE---FVEVSARQTDnELHIIVEDDGPGIPRNKRDVVFD--------RGQRADTlrpGQGVGLAVA 450
Cdd:PRK11091 401 QILWNLISNAVKFTQQggvTVRVRYEEGD-MLTFEVEDSGIGIPEDELDKIFAmyyqvkdsHGGKPAT---GTGIGLAVS 476
                         90
                 ....*....|....*.
gi 495776180 451 REIVDQYDGKIE-TSE 465
Cdd:PRK11091 477 KRLAQAMGGDITvTSE 492
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
271-471 7.25e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 45.45  E-value: 7.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 271 TLTDLTHSLKTPLAVMQSTLRSMRSS-KLSVDDAEPVMLEQISRISQQIGYYLhrASMRSGSALLSRELHPVaPLLDNLT 349
Cdd:COG4192  436 TMTSLAHELNQPLNAMSMYLFSAKKAlEQENYAQLPTSLDKIEGLIERMDKII--KSLRQFSRKSDTPLQPV-DLRQVIE 512
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 350 SALNKVYQR-KGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTDN--ELHIIVEDDGPGIPRNKR 426
Cdd:COG4192  513 QAWELVESRaKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNaeNLRVAISDNGNGWPLVDK 592
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 495776180 427 dvvfdrgqradTLRP-------GQGVGLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:COG4192  593 -----------LFTPftttkevGLGLGLSICRSIMQQFGGDLYLASTLERGA 633
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
272-330 8.34e-05

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 40.66  E-value: 8.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495776180  272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:pfam00512   6 LANLSHELRTPLTAIRGYLELLRDEKLDEEQREylETILRSAERLLRLINDLLDLSRIEAG 66
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
272-330 9.59e-05

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 40.24  E-value: 9.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495776180   272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:smart00388   6 LANLSHELRTPLTAIRGYLELLLDTELSEEQREylETILREAERLLRLINDLLDLSRIEAG 66
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
357-465 2.67e-04

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 43.24  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 357 QRKGVNISLDISPEISFVGEKNDFM-EVMGNLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDrg 433
Cdd:PRK10364 325 NSREIQLRFTANDTLPEIQADPDRLtQVLLNLYLNAIQAIGQhgVISVTASESGAGVKISVTDSGKGIAADQLEAIFT-- 402
                         90       100       110
                 ....*....|....*....|....*....|...
gi 495776180 434 QRADTLRPGQGVGLAVAREIVDQYDGKIE-TSE 465
Cdd:PRK10364 403 PYFTTKAEGTGLGLAVVHNIVEQHGGTIQvASQ 435
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
386-477 2.68e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 40.52  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 386 NLLDNACKYCLE--FVEVSARQTDNELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQ---GVGLAVAREIVDQYDGK 460
Cdd:cd16975   11 NIISNACQYAPEggTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGghyGMGLYIAKNLVEKHGGS 90
                         90
                 ....*....|....*..
gi 495776180 461 IETSESLLGGArmEVIF 477
Cdd:cd16975   91 LIIENSQKGGA--EVTV 105
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
399-475 2.44e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.15  E-value: 2.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495776180 399 VEVSARQTDNELHIIVEDDGPGiprnkrdvvFDRGQRAdtlrPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEV 475
Cdd:cd16917   21 VRVTLSYTADELTLTVVDDGVG---------FDGPAPP----GGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTA 84
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
359-465 4.88e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 39.45  E-value: 4.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 359 KGVNISLDISPEI--SFVGEKNDFMEVMGNLLDNACKycleFVE-------VSAR-QTDN--ELHIIVEDDGPGIPRNKR 426
Cdd:PRK11107 386 KGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIK----FTEsgnidilVELRaLSNTkvQLEVQIRDTGIGISERQQ 461
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 495776180 427 DVVFDRGQRADT----LRPGQGVGLAVAREIVDQYDGKIE-TSE 465
Cdd:PRK11107 462 SQLFQAFRQADAsisrRHGGTGLGLVITQKLVNEMGGDISfHSQ 505
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
221-378 5.24e-03

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 39.28  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 221 IESLAKEVREL-EEHHREKLNPE--TTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMqSTLRSMRSSK 297
Cdd:COG5244   88 ESKGMDKDGEIkQENHEDRIHFEesKIRRLEETIEALKSTEKEEIVELRRENEELDKINLSLRERISSE-EPELNKDGSK 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776180 298 LSVDDAEPVMLE-------------QISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRkgvnis 364
Cdd:COG5244  167 LSYDELKEFVEEsrvqvydmvelvsDISETLNRNGSIQRSSVRECERSNIHDVLFLVNGILDGVIDELNGELER------ 240
                        170
                 ....*....|....
gi 495776180 365 ldISPEISFVGEKN 378
Cdd:COG5244  241 --LRRQLVSLMSSH 252
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
390-455 7.58e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 35.71  E-value: 7.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495776180 390 NACKYCLEF-----VEVSARQTDNELHIIVEDDGPGIPRNkrdvvfdRGQRADTLRPGQGVGLAVAREIVD 455
Cdd:cd16936   11 NAVRHAYRHdgpgpVRLELDLDPDRLRVEVTDSGPGFDPL-------RPADPDAGLREGGRGLALIRALMD 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH