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Conserved domains on  [gi|495776587|ref|WP_008501166|]
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MULTISPECIES: DUF1471 family periplasmic protein McbA [Enterobacter cloacae complex]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
peri_YbiM_McbA super family cl45833
DUF1471 family periplasmic protein McbA; McbA (YbiM) is a member of the DUF1471 family found ...
 1-88 2.68e-32

DUF1471 family periplasmic protein McbA; McbA (YbiM) is a member of the DUF1471 family found in Escherichia coli K-12, where it is one of many paralogs, but not found in Salmonella enterica LT2. Many members of the DUF1471 family of small enterobacterial periplasmic proteins participate in response to various forms of stress, such as low pH.


The actual alignment was detected with superfamily member NF040473:

Pssm-ID: 439700  Cd Length: 86  Bit Score: 107.37  E-value: 2.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776587  1 MKKYLTLVvIASALTTASFSAMAVQSLTqSTDTSQLQPAGTVSVSRASNLDDLQNKLAEKARQEGAKGFVVNSAGGDNHM 80
Cdd:NF040473  1 MKKCLTFL-AATVLTGMSFAAFAAQPMS-SPDTGQLRPAGTVSATGASNLSDLEDKLAEKAREQGAKGFVVNSAGGKNQM 78


                ....*...
gi 495776587 81 YGTATIYK 88
Cdd:NF040473 79 YGTATIYK 86
 
Name Accession Description Interval E-value
peri_YbiM_McbA NF040473
DUF1471 family periplasmic protein McbA; McbA (YbiM) is a member of the DUF1471 family found ...
 1-88 2.68e-32

DUF1471 family periplasmic protein McbA; McbA (YbiM) is a member of the DUF1471 family found in Escherichia coli K-12, where it is one of many paralogs, but not found in Salmonella enterica LT2. Many members of the DUF1471 family of small enterobacterial periplasmic proteins participate in response to various forms of stress, such as low pH.


Pssm-ID: 439700  Cd Length: 86  Bit Score: 107.37  E-value: 2.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776587  1 MKKYLTLVvIASALTTASFSAMAVQSLTqSTDTSQLQPAGTVSVSRASNLDDLQNKLAEKARQEGAKGFVVNSAGGDNHM 80
Cdd:NF040473  1 MKKCLTFL-AATVLTGMSFAAFAAQPMS-SPDTGQLRPAGTVSATGASNLSDLEDKLAEKAREQGAKGFVVNSAGGKNQM 78


                ....*...
gi 495776587 81 YGTATIYK 88
Cdd:NF040473 79 YGTATIYK 86
PRK10259 PRK10259
hypothetical protein; Provisional
 3-88 6.52e-13

hypothetical protein; Provisional


Pssm-ID: 137782  Cd Length: 86  Bit Score: 58.19  E-value: 6.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776587  3 KYLTLVVIASALTTASFSAMAVQSLTQStDTSQLQPAGTVSVSRASNLDDLQNKLAEKARQEGAKGFVVNSAGGDNHMYG 82
Cdd:PRK10259  2 KTINTVVAAMALSTLSFGVFAAEPVTAS-QAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSG 80


                ....*.
gi 495776587 83 TATIYK 88
Cdd:PRK10259 81 TAVIYK 86
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 36-87 1.55e-12

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 56.38  E-value: 1.55e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495776587  36 LQPAGTVSVS-RASNLDDLQNKLAEKARQEGAKGFVVNSAGG--DNHMYGTATIY 87
Cdd:pfam07338  1 LQPIGTVSVSgVFGSPSDAEAALSKKADAKGAKSYRIISADEpnGGNWHGTAELY 55
 
Name Accession Description Interval E-value
peri_YbiM_McbA NF040473
DUF1471 family periplasmic protein McbA; McbA (YbiM) is a member of the DUF1471 family found ...
 1-88 2.68e-32

DUF1471 family periplasmic protein McbA; McbA (YbiM) is a member of the DUF1471 family found in Escherichia coli K-12, where it is one of many paralogs, but not found in Salmonella enterica LT2. Many members of the DUF1471 family of small enterobacterial periplasmic proteins participate in response to various forms of stress, such as low pH.


Pssm-ID: 439700  Cd Length: 86  Bit Score: 107.37  E-value: 2.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776587  1 MKKYLTLVvIASALTTASFSAMAVQSLTqSTDTSQLQPAGTVSVSRASNLDDLQNKLAEKARQEGAKGFVVNSAGGDNHM 80
Cdd:NF040473  1 MKKCLTFL-AATVLTGMSFAAFAAQPMS-SPDTGQLRPAGTVSATGASNLSDLEDKLAEKAREQGAKGFVVNSAGGKNQM 78


                ....*...
gi 495776587 81 YGTATIYK 88
Cdd:NF040473 79 YGTATIYK 86
PRK10259 PRK10259
hypothetical protein; Provisional
 3-88 6.52e-13

hypothetical protein; Provisional


Pssm-ID: 137782  Cd Length: 86  Bit Score: 58.19  E-value: 6.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776587  3 KYLTLVVIASALTTASFSAMAVQSLTQStDTSQLQPAGTVSVSRASNLDDLQNKLAEKARQEGAKGFVVNSAGGDNHMYG 82
Cdd:PRK10259  2 KTINTVVAAMALSTLSFGVFAAEPVTAS-QAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSG 80


                ....*.
gi 495776587 83 TATIYK 88
Cdd:PRK10259 81 TAVIYK 86
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 36-87 1.55e-12

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 56.38  E-value: 1.55e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495776587  36 LQPAGTVSVS-RASNLDDLQNKLAEKARQEGAKGFVVNSAGG--DNHMYGTATIY 87
Cdd:pfam07338  1 LQPIGTVSVSgVFGSPSDAEAALSKKADAKGAKSYRIISADEpnGGNWHGTAELY 55
PRK09929 PRK09929
hypothetical protein; Provisional
 1-88 1.50e-08

hypothetical protein; Provisional


Pssm-ID: 182151  Cd Length: 91  Bit Score: 47.21  E-value: 1.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495776587  1 MKKYLTLVVIASAL-TTASFSAMAVQSLTQSTDTSQLQPAGTVSVSRASNLDDLQNKLAEKARQEGAKGFVVNSAGGDNH 79
Cdd:PRK09929  1 MKIISKMLLGALAFaVTNVYAAELMTKAEFEKVESQYEKIGTISTSNEMSTADAKEDLIKKADEKGADVLVLTSGQTDNK 80


                ....*....
gi 495776587 80 MYGTATIYK 88
Cdd:PRK09929 81 IHGTADIYK 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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