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Conserved domains on  [gi|495777987|ref|WP_008502566|]
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MULTISPECIES: DNA-binding protein StpA [Enterobacter]

Protein Classification

DNA-binding protein StpA( domain architecture ID 11484657)

DNA-binding protein StpA acts in a fashion similar to H-NS protein upon overexpression, repressing a number of genes including the cryptic blg operon, hns, papB and the proU locus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10328 PRK10328
DNA-binding protein StpA;
1-134 8.80e-76

DNA-binding protein StpA;


:

Pssm-ID: 182380 [Multi-domain]  Cd Length: 134  Bit Score: 220.90  E-value: 8.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   1 MSLTLQNLNNIRTLRAMARELSLDVLEEMLEKVRVVAEEKRSELAELEQQRAEQQEKINALLERMKADGISPTDLLGSEL 80
Cdd:PRK10328   1 MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKINTWLELMKADGINPEELLGNSS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495777987  81 AQTGKSTKKRKPREAKYRFIDQNGEEKTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:PRK10328  81 AAAPRAGKKRQPRPAKYRFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI 134
 
Name Accession Description Interval E-value
PRK10328 PRK10328
DNA-binding protein StpA;
1-134 8.80e-76

DNA-binding protein StpA;


Pssm-ID: 182380 [Multi-domain]  Cd Length: 134  Bit Score: 220.90  E-value: 8.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   1 MSLTLQNLNNIRTLRAMARELSLDVLEEMLEKVRVVAEEKRSELAELEQQRAEQQEKINALLERMKADGISPTDLLGSEL 80
Cdd:PRK10328   1 MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKINTWLELMKADGINPEELLGNSS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495777987  81 AQTGKSTKKRKPREAKYRFIDQNGEEKTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:PRK10328  81 AAAPRAGKKRQPRPAKYRFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI 134
Hns COG2916
DNA-binding protein H-NS [Transcription];
17-134 2.57e-32

DNA-binding protein H-NS [Transcription];


Pssm-ID: 442160 [Multi-domain]  Cd Length: 109  Bit Score: 109.98  E-value: 2.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987  17 MARELSLDVLEEMLEKVRVVAEEKRselaeleqqRAEQQEKINALLERMKADGISPTDLLGSelAQTGKSTKKRKPREAK 96
Cdd:COG2916    4 DLRELSLEELEELIEKLEKVIEELE---------KRERAEALAEIKELAAEYGISLEELLGA--LAAKKAKKKRAKVPAK 72

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 495777987  97 YRfiDQNGEEKTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:COG2916   73 YR--DPNGPGKTWTGRGRKPKWIKAALAAGKSLEDFLI 108
Histone_HNS pfam00816
H-NS histone family;
38-128 4.03e-20

H-NS histone family;


Pssm-ID: 425884 [Multi-domain]  Cd Length: 91  Bit Score: 78.47  E-value: 4.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   38 EEKRSELAELEQQraEQQEKINALLERMKADGISPTDLLGSELAqTGKSTKKRKPREAKYRfiDQNGEEKTWTGQGRTPK 117
Cdd:pfam00816   6 AELEKEIEALRKR--ERKEVLAQIRELAAEYGLTLEELGGAAKA-ARKAKAKAAKVPAKYR--DPATPGETWTGRGRKPK 80

                          90
                  ....*....|.
gi 495777987  118 PIASALAEGKS 128
Cdd:pfam00816  81 WIKAALAAGKS 91
HNS smart00528
Domain in histone-like proteins of HNS family;
87-134 1.62e-18

Domain in histone-like proteins of HNS family;


Pssm-ID: 128801  Cd Length: 46  Bit Score: 73.23  E-value: 1.62e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 495777987    87 TKKRKPREAKYRFIDQNGEekTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:smart00528   1 KKKRAARPAKYRYPDNNGE--TWSGRGRTPRWLAAALDSGKSLEDFLI 46
 
Name Accession Description Interval E-value
PRK10328 PRK10328
DNA-binding protein StpA;
1-134 8.80e-76

DNA-binding protein StpA;


Pssm-ID: 182380 [Multi-domain]  Cd Length: 134  Bit Score: 220.90  E-value: 8.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   1 MSLTLQNLNNIRTLRAMARELSLDVLEEMLEKVRVVAEEKRSELAELEQQRAEQQEKINALLERMKADGISPTDLLGSEL 80
Cdd:PRK10328   1 MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKINTWLELMKADGINPEELLGNSS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495777987  81 AQTGKSTKKRKPREAKYRFIDQNGEEKTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:PRK10328  81 AAAPRAGKKRQPRPAKYRFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI 134
PRK10947 PRK10947
DNA-binding transcriptional regulator H-NS;
1-134 3.66e-38

DNA-binding transcriptional regulator H-NS;


Pssm-ID: 182858  Cd Length: 135  Bit Score: 125.80  E-value: 3.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   1 MSLTLQNLNNIRTLRAMARELSLDVLEEMLEKVRVVAEEKRSELAELEQQRAEQQEKINALLERMKADGISPTDLLGSEL 80
Cdd:PRK10947   1 MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495777987  81 AQTGKSTKKRKPREAKYRFIDQNGEEKTWTGQGRTPKPIASALAE-GKSLDDFLI 134
Cdd:PRK10947  81 AVKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEqGKSLDDFLI 135
Hns COG2916
DNA-binding protein H-NS [Transcription];
17-134 2.57e-32

DNA-binding protein H-NS [Transcription];


Pssm-ID: 442160 [Multi-domain]  Cd Length: 109  Bit Score: 109.98  E-value: 2.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987  17 MARELSLDVLEEMLEKVRVVAEEKRselaeleqqRAEQQEKINALLERMKADGISPTDLLGSelAQTGKSTKKRKPREAK 96
Cdd:COG2916    4 DLRELSLEELEELIEKLEKVIEELE---------KRERAEALAEIKELAAEYGISLEELLGA--LAAKKAKKKRAKVPAK 72

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 495777987  97 YRfiDQNGEEKTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:COG2916   73 YR--DPNGPGKTWTGRGRKPKWIKAALAAGKSLEDFLI 108
Histone_HNS pfam00816
H-NS histone family;
38-128 4.03e-20

H-NS histone family;


Pssm-ID: 425884 [Multi-domain]  Cd Length: 91  Bit Score: 78.47  E-value: 4.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   38 EEKRSELAELEQQraEQQEKINALLERMKADGISPTDLLGSELAqTGKSTKKRKPREAKYRfiDQNGEEKTWTGQGRTPK 117
Cdd:pfam00816   6 AELEKEIEALRKR--ERKEVLAQIRELAAEYGLTLEELGGAAKA-ARKAKAKAAKVPAKYR--DPATPGETWTGRGRKPK 80

                          90
                  ....*....|.
gi 495777987  118 PIASALAEGKS 128
Cdd:pfam00816  81 WIKAALAAGKS 91
HNS smart00528
Domain in histone-like proteins of HNS family;
87-134 1.62e-18

Domain in histone-like proteins of HNS family;


Pssm-ID: 128801  Cd Length: 46  Bit Score: 73.23  E-value: 1.62e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 495777987    87 TKKRKPREAKYRFIDQNGEekTWTGQGRTPKPIASALAEGKSLDDFLI 134
Cdd:smart00528   1 KKKRAARPAKYRYPDNNGE--TWSGRGRTPRWLAAALDSGKSLEDFLI 46
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
11-98 1.29e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.59  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495777987   11 IRTLRAMARELSLDVLEEMLEKVRVVAEEKRSELAELEQQRAEQQEKINALLERMKADGISPTDLLGSELAQTGKSTKKR 90
Cdd:COG4913   278 RAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEER 357


                  ....*...
gi 495777987   91 KPREAKYR 98
Cdd:COG4913   358 ERRRARLE 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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