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Conserved domains on  [gi|495778308|ref|WP_008502887|]
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MULTISPECIES: AraC family transcriptional regulator [Enterobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12033754)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 158-274 2.42e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.46  E-value: 2.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 158 FAHHAPRVQEGAHRFERVREYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MP 236
Cdd:COG4977  198 FSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLS 277

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 495778308 237 AAEVAAATGLTDQSHLTRAFTHRYGITPVRYQKQVTRR 274
Cdd:COG4977  278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 1.32e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 88.30  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  16 RFRHLAQLPGLELYHAHISDYAFEPHTHEAFGIGTIETGAERFRYRGSQHLAAEKSVVTMNPDEIHTGESATEGGWRYRM 95
Cdd:COG2207    2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  96 VYIEPDLLEEVTGLRHWWFSDVTRHDPLRSQQIGRLIYGLWHTDDPLAQKGLLLDLIETFQPFAHHAPRVQEGAHRFERV 175
Cdd:COG2207   82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 176 REYLhdnyMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTR 254
Cdd:COG2207  162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                        250       260
                 ....*....|....*....|
gi 495778308 255 AFTHRYGITPVRYQKQVTRR 274
Cdd:COG2207  238 AFKKRFGVTPSEYRKRLRAR 257
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 158-274 2.42e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.46  E-value: 2.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 158 FAHHAPRVQEGAHRFERVREYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MP 236
Cdd:COG4977  198 FSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLS 277

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 495778308 237 AAEVAAATGLTDQSHLTRAFTHRYGITPVRYQKQVTRR 274
Cdd:COG4977  278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 1.32e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 88.30  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  16 RFRHLAQLPGLELYHAHISDYAFEPHTHEAFGIGTIETGAERFRYRGSQHLAAEKSVVTMNPDEIHTGESATEGGWRYRM 95
Cdd:COG2207    2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  96 VYIEPDLLEEVTGLRHWWFSDVTRHDPLRSQQIGRLIYGLWHTDDPLAQKGLLLDLIETFQPFAHHAPRVQEGAHRFERV 175
Cdd:COG2207   82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 176 REYLhdnyMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTR 254
Cdd:COG2207  162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                        250       260
                 ....*....|....*....|
gi 495778308 255 AFTHRYGITPVRYQKQVTRR 274
Cdd:COG2207  238 AFKKRFGVTPSEYRKRLRAR 257
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
187-267 2.48e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 2.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308   187 LTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTHRYGITPV 265
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 495778308   266 RY 267
Cdd:smart00342  82 EY 83
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 23-137 3.05e-20

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 84.02  E-value: 3.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308   23 LPGLELYHAHISDYAFEPHTHEAFGIGTIETGAERFRYRGSQHLAAEKSVVTMNPDEIHTGESATEGGWRYRMVYIEPDL 102
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 495778308  103 LEEVTGLRHWwfSDVTRHDPLRSQQIGRLIYGLWH 137
Cdd:pfam02311  81 LERILADISI--LAGGPLPLLRDPELAALLRALFR 113
HTH_18 pfam12833
Helix-turn-helix domain;
192-270 9.89e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.10  E-value: 9.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  192 LASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTH--GMPAAEVAAATGLTDQSHLTRAFTHRYGITPVRYQK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 495778308  270 Q 270
Cdd:pfam12833  81 R 81
ftrA PRK09393
transcriptional activator FtrA; Provisional
 172-270 6.53e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 6.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 172 FERVREYLHDNYmralTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL-THGMPAAEVAAATGLTDQS 250
Cdd:PRK09393 224 IDWMRAHLAEPH----TVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEE 299

                         90       100
                 ....*....|....*....|
gi 495778308 251 HLTRAFTHRYGITPVRYQKQ 270
Cdd:PRK09393 300 SLRHHFRRRAATSPAAYRKR 319
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 158-274 2.42e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.46  E-value: 2.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 158 FAHHAPRVQEGAHRFERVREYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MP 236
Cdd:COG4977  198 FSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLS 277

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 495778308 237 AAEVAAATGLTDQSHLTRAFTHRYGITPVRYQKQVTRR 274
Cdd:COG4977  278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 162-270 1.00e-20

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 90.11  E-value: 1.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 162 APRVQEGAHRFERVREYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHGMPAAEVA 241
Cdd:COG2169   76 APGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAA 155

                         90       100
                 ....*....|....*....|....*....
gi 495778308 242 AATGLTDQSHLTRAFTHRYGITPVRYQKQ 270
Cdd:COG2169  156 YAAGFGSLSRFYEAFKKLLGMTPSAYRRG 184
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 1.32e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 88.30  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  16 RFRHLAQLPGLELYHAHISDYAFEPHTHEAFGIGTIETGAERFRYRGSQHLAAEKSVVTMNPDEIHTGESATEGGWRYRM 95
Cdd:COG2207    2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  96 VYIEPDLLEEVTGLRHWWFSDVTRHDPLRSQQIGRLIYGLWHTDDPLAQKGLLLDLIETFQPFAHHAPRVQEGAHRFERV 175
Cdd:COG2207   82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 176 REYLhdnyMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTR 254
Cdd:COG2207  162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                        250       260
                 ....*....|....*....|
gi 495778308 255 AFTHRYGITPVRYQKQVTRR 274
Cdd:COG2207  238 AFKKRFGVTPSEYRKRLRAR 257
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
187-267 2.48e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 2.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308   187 LTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTHRYGITPV 265
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 495778308   266 RY 267
Cdd:smart00342  82 EY 83
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 23-137 3.05e-20

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 84.02  E-value: 3.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308   23 LPGLELYHAHISDYAFEPHTHEAFGIGTIETGAERFRYRGSQHLAAEKSVVTMNPDEIHTGESATEGGWRYRMVYIEPDL 102
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 495778308  103 LEEVTGLRHWwfSDVTRHDPLRSQQIGRLIYGLWH 137
Cdd:pfam02311  81 LERILADISI--LAGGPLPLLRDPELAALLRALFR 113
HTH_18 pfam12833
Helix-turn-helix domain;
192-270 9.89e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.10  E-value: 9.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  192 LASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTH--GMPAAEVAAATGLTDQSHLTRAFTHRYGITPVRYQK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 495778308  270 Q 270
Cdd:pfam12833  81 R 81
ftrA PRK09393
transcriptional activator FtrA; Provisional
 172-270 6.53e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 6.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 172 FERVREYLHDNYmralTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL-THGMPAAEVAAATGLTDQS 250
Cdd:PRK09393 224 IDWMRAHLAEPH----TVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEE 299

                         90       100
                 ....*....|....*....|
gi 495778308 251 HLTRAFTHRYGITPVRYQKQ 270
Cdd:PRK09393 300 SLRHHFRRRAATSPAAYRKR 319
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
186-269 8.00e-10

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 58.65  E-value: 8.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 186 ALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHGMPAAEVAAATGLTDQSHLTRAFTHRYGITPV 265
Cdd:PRK15435  99 PVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAKGESVTTSILNAGFPDSSSYYRKADETLGMTAK 178


                 ....
gi 495778308 266 RYQK 269
Cdd:PRK15435 179 QFRH 182
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 179-219 1.00e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 44.45  E-value: 1.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 495778308  179 LHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQML 219
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYR 41
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
91-270 1.63e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 48.43  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308  91 WRYRMVYIEPdlleevtglRHWW-----FSDVTRH-------DPLRSQQIGRLIYGLWHT---DDPLAQ-------KGLL 148
Cdd:PRK10572  96 WYHQWVYFRP---------RAYWadwlnWPSIFAGvgrlripDEALQPEFSDLFGQIEQAgqsEGRYSEllamnllERLL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 149 LDLIETfQPFAHHAPRvqegAHRFERVREYLHDNYMRALTLDELASVVSLSPYHFQRQFKahfhvtpHQMLMAIRLWR-- 226
Cdd:PRK10572 167 LRCMEA-IPESLHPPM----DPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFR-------QQLGISVLRWRed 234

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 495778308 227 -----AKAFL-THGMPAAEVAAATGLTDQSHLTRAFTHRYGITPVRYQKQ 270
Cdd:PRK10572 235 qrisrAKLLLqTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
164-264 6.98e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 43.51  E-value: 6.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 164 RVQEGAHRFERVRE---YLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAE 239
Cdd:PRK13503 162 LQENGENSDARLNQllaWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSdASVTD 241

                         90       100
                 ....*....|....*....|....*
gi 495778308 240 VAAATGLTDQSHLTRAFTHRYGITP 264
Cdd:PRK13503 242 IAYRCGFGDSNHFSTLFRREFSWSP 266
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 142-270 1.68e-04

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 42.22  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 142 LAQKGLLLDLIETFQPFAHHAPRVQEGAHRFERVR--EYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHfHVTPHQML 219
Cdd:PRK09978 112 LRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRvcTVINNNIAHEWTLARIASELLMSPSLLKKKLREE-ETSYSQLL 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 495778308 220 MAIRLWRA-KAFLTHGMPAAEVAAATGLTDQSHLTRAFTHRYGITPVRYQKQ 270
Cdd:PRK09978 191 TECRMQRAlQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQER 242
PRK10371 PRK10371
transcriptional regulator MelR;
177-274 1.00e-03

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 39.80  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 177 EYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTH-GMPAAEVAAATGLTDQSHLTRA 255
Cdd:PRK10371 198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDtDKSILDIALTAGFRSSSRFYST 277

                         90
                 ....*....|....*....
gi 495778308 256 FTHRYGITPVRYQKQVTRR 274
Cdd:PRK10371 278 FGKYVGMSPQQYRKLSQQR 296
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
140-268 1.70e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 39.27  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 140 DPLAQKG---LLLDLIETFQPFAHHAPRVQEGAHR--FERVREYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHFHVT 214
Cdd:PRK13502 141 DPLANEMaelLFGQLVMTLKRHRYATDDLPATSREtlLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMT 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495778308 215 PHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTHRYGITPVRYQ 268
Cdd:PRK13502 221 INQYLRQVRICHAQYLLQHSpLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
175-268 3.58e-03

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 36.62  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778308 175 VREYLHDNYMRALTLDELASVVSLSPYHFQRQFKAHfhvTPHQMLMAIRLWR----AKAFLTHGMPAAEVAAATGLTDQS 250
Cdd:PRK11511  14 ILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKE---TGHSLGQYIRSRKmteiAQKLKESNEPILYLAERYGFESQQ 90

                         90
                 ....*....|....*...
gi 495778308 251 HLTRAFTHRYGITPVRYQ 268
Cdd:PRK11511  91 TLTRTFKNYFDVPPHKYR 108
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 231-269 8.33e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 33.67  E-value: 8.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 495778308  231 LTHGMPAAEVAAATGLtDQSHLTRAFTHRYGITPVRYQK 269
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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