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Conserved domains on  [gi|495778348|ref|WP_008502927|]
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MULTISPECIES: small ribosomal subunit biogenesis GTPase RsgA [Enterobacter]

Protein Classification

ribosome small subunit-dependent GTPase A( domain architecture ID 11485742)

ribosome small subunit-dependent GTPase A (RsgA) is a late-stage ribosome biogenesis factor involved in 30S subunit maturation

Gene Ontology:  GO:0005525|GO:0003924
PubMed:  15466596|21529161

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12288 PRK12288
small ribosomal subunit biogenesis GTPase RsgA;
1-350 0e+00

small ribosomal subunit biogenesis GTPase RsgA;


:

Pssm-ID: 237039 [Multi-domain]  Cd Length: 347  Bit Score: 687.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348   1 MSKNKLSKGQQRRVNANHQRRLKTTAEKVDYDDNLFGDPTEGVVISRFGMHADVESADGAIHRCNIRRTIRSLVTGDRVV 80
Cdd:PRK12288   1 MSKRKLSKGQQRRVEANHQKRLKTSKEKPELDDSLLGEEQEGIVISRFGQHADVEAADGEVHRCNIRRTIRSLVTGDRVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  81 WRPGKEAAEGVtvKGIVEAVHERTSVLTRPDFYDGVKPIAANINQIVIVSAILPELSLNIIDRYLVACETLQVEPIIVLN 160
Cdd:PRK12288  81 WRPGKEALEGV--SGVVEAVHPRTSVLTRPDYYDGVKPIAANIDQIVIVSAVLPELSLNIIDRYLVACETLGIEPLIVLN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 161 KIDLLDDDGMAFVNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKsSLLNNLLGLQQEILTNDVS 240
Cdd:PRK12288 159 KIDLLDDEGRAFVNEQLDIYRNIGYRVLMVSSHTGEGLEELEAALTGRISIFVGQSGVGK-SSLINALLPEAEILVGDVS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 241 DVSGLGQHTTTASRLYHFPHGGDVIDSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGE 320
Cdd:PRK12288 238 DNSGLGQHTTTAARLYHFPHGGDLIDSPGVREFGLWHLEPEQVTQGFVEFRDYLGTCKFRDCKHDDDPGCALREAVEEGK 317

                        330       340       350
                 ....*....|....*....|....*....|
gi 495778348 321 IAETRFENYHRILESMDQVKTRKNFSDSDN 350
Cdd:PRK12288 318 IAETRFENYHRILESMAEVKTRRHFSDTDD 347
 
Name Accession Description Interval E-value
PRK12288 PRK12288
small ribosomal subunit biogenesis GTPase RsgA;
1-350 0e+00

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237039 [Multi-domain]  Cd Length: 347  Bit Score: 687.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348   1 MSKNKLSKGQQRRVNANHQRRLKTTAEKVDYDDNLFGDPTEGVVISRFGMHADVESADGAIHRCNIRRTIRSLVTGDRVV 80
Cdd:PRK12288   1 MSKRKLSKGQQRRVEANHQKRLKTSKEKPELDDSLLGEEQEGIVISRFGQHADVEAADGEVHRCNIRRTIRSLVTGDRVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  81 WRPGKEAAEGVtvKGIVEAVHERTSVLTRPDFYDGVKPIAANINQIVIVSAILPELSLNIIDRYLVACETLQVEPIIVLN 160
Cdd:PRK12288  81 WRPGKEALEGV--SGVVEAVHPRTSVLTRPDYYDGVKPIAANIDQIVIVSAVLPELSLNIIDRYLVACETLGIEPLIVLN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 161 KIDLLDDDGMAFVNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKsSLLNNLLGLQQEILTNDVS 240
Cdd:PRK12288 159 KIDLLDDEGRAFVNEQLDIYRNIGYRVLMVSSHTGEGLEELEAALTGRISIFVGQSGVGK-SSLINALLPEAEILVGDVS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 241 DVSGLGQHTTTASRLYHFPHGGDVIDSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGE 320
Cdd:PRK12288 238 DNSGLGQHTTTAARLYHFPHGGDLIDSPGVREFGLWHLEPEQVTQGFVEFRDYLGTCKFRDCKHDDDPGCALREAVEEGK 317

                        330       340       350
                 ....*....|....*....|....*....|
gi 495778348 321 IAETRFENYHRILESMDQVKTRKNFSDSDN 350
Cdd:PRK12288 318 IAETRFENYHRILESMAEVKTRRHFSDTDD 347
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
41-342 1.39e-135

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 387.55  E-value: 1.39e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  41 EGVVISRFGMHADVESADGAIHRCNIRRTIR----SLVTGDRVVWRPGKEAaegvtvKGIVEAVHERTSVLTRPDFY-DG 115
Cdd:COG1162    3 PGRVIKVHGGRYYVETEDGERYRCRLRGKLRkkgiSPVVGDWVEIEPDDDG------EGVIEEILPRKNLLVRPAVGrDK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 116 VKPIAANINQIVIVSAIL-PELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDGMAfvnEQMDIYRKIGYRVLMVSSYT 194
Cdd:COG1162   77 EQVIAANIDQVLIVVALAePDFNLRLLDRYLVAAEAAGIEPVIVLNKADLADDEELE---ELLAIYEALGYPVLAVSAKT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 195 KDGLKPLEEALTDRISIFAGQSGVGK---------SSllnnllglqqEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVI 265
Cdd:COG1162  154 GEGLDELRELLKGKTSVLVGQSGVGKstlinallpDA----------DLATGEISEKLGRGRHTTTHAELYPLPGGGWLI 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495778348 266 DSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGEIAETRFENYHRILESMDQVKTR 342
Cdd:COG1162  224 DTPGFREFGLWHIEPEELAHYFPEFRELAGQCRFRDCTHLHEPGCAVKAAVEAGEISPERYESYLKLLEELEERKRR 300
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
 73-334 2.77e-115

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 334.00  E-value: 2.77e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348   73 LVTGDRVVWRPGKEaaegvtVKGIVEAVHERTSVLTRPdfydgvkpIAANINQIVIV-SAILPELSLNIIDRYLVACETL 151
Cdd:TIGR00157   1 LVVGDRVVWEPGNP------VKVYGGAIAERKNELTRP--------IVANIDQIVIVsSAVLPELSLNQLDRFLVVAEAQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  152 QVEPIIVLNKIDLLDDDGMAfvNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKSSLLNNLLGLQ 231
Cdd:TIGR00157  67 NIEPIIVLNKIDLLDDEDME--KEQLDIYRNIGYQVLMTSSKNQDGLKELIEALQNRISVFAGQSGVGKSSLINALDPSV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  232 QEIlTNDVSDVSGLGQHTTTASRLYHFpHGGDVIDSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCA 311
Cdd:TIGR00157 145 KQQ-VNDISSKLGLGKHTTTHVELFHF-HGGLIADTPGFNEFGLWHLEPEQLTQGFVEFRDYLGLCKFRDCLHQSEPGCA 222

                         250       260
                  ....*....|....*....|...
gi 495778348  312 IREAVEKGEIAETRFENYHRILE 334
Cdd:TIGR00157 223 VRQAVEQGEISEWRYENYLKLIE 245
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 121-334 1.77e-98

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 290.07  E-value: 1.77e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 121 ANINQIVIVSAIL-PELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDGMAfvnEQMDIYRKIGYRVLMVSSYTKDGLK 199
Cdd:cd01854    1 ANVDQVLIVFSLKePFFNLRLLDRYLVAAEASGIEPVIVLNKADLVDDEELE---ELLEIYEKLGYPVLAVSAKTGEGLD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 200 PLEEALTDRISIFAGQSGVGK---------SSllnnllglqqEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVIDSPGV 270
Cdd:cd01854   78 ELRELLKGKTSVLVGQSGVGKstllnallpEL----------VLATGEISEKLGRGRHTTTHRELFPLPGGGLIIDTPGF 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495778348 271 REFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGEIAETRFENYHRILE 334
Cdd:cd01854  148 RELGLLHIDPEELAEYFPEFEELAGQCRFRDCTHINEPGCAVKAAVEAGEISEERYESYLKLLE 211
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
 100-276 4.83e-74

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 226.65  E-value: 4.83e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  100 VHERTSVLTRPDFYDGvKPIAANINQIVIVSAIL-PELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDgmAFVNEQMD 178
Cdd:pfam03193   1 VLPRKNLLVRPPAGRR-QIIVANVDQAVIVFSLKePDFNLNLLDRFLVLAEASGIEPVIVLNKIDLLDEE--EELEELLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  179 IYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKsSLLNNLLGLQQEILTNDVSDVSGLGQHTTTASRLYHF 258
Cdd:pfam03193  78 IYRAIGYPVLFVSAKTGEGIEALKELLKGKTTVLAGQSGVGK-STLLNALLPELDLRTGEISEKLGRGRHTTTHVELFPL 156

                         170
                  ....*....|....*...
gi 495778348  259 PHGGDVIDSPGVREFGLW 276
Cdd:pfam03193 157 PGGGLLIDTPGFRELGLW 174
 
Name Accession Description Interval E-value
PRK12288 PRK12288
small ribosomal subunit biogenesis GTPase RsgA;
1-350 0e+00

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237039 [Multi-domain]  Cd Length: 347  Bit Score: 687.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348   1 MSKNKLSKGQQRRVNANHQRRLKTTAEKVDYDDNLFGDPTEGVVISRFGMHADVESADGAIHRCNIRRTIRSLVTGDRVV 80
Cdd:PRK12288   1 MSKRKLSKGQQRRVEANHQKRLKTSKEKPELDDSLLGEEQEGIVISRFGQHADVEAADGEVHRCNIRRTIRSLVTGDRVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  81 WRPGKEAAEGVtvKGIVEAVHERTSVLTRPDFYDGVKPIAANINQIVIVSAILPELSLNIIDRYLVACETLQVEPIIVLN 160
Cdd:PRK12288  81 WRPGKEALEGV--SGVVEAVHPRTSVLTRPDYYDGVKPIAANIDQIVIVSAVLPELSLNIIDRYLVACETLGIEPLIVLN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 161 KIDLLDDDGMAFVNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKsSLLNNLLGLQQEILTNDVS 240
Cdd:PRK12288 159 KIDLLDDEGRAFVNEQLDIYRNIGYRVLMVSSHTGEGLEELEAALTGRISIFVGQSGVGK-SSLINALLPEAEILVGDVS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 241 DVSGLGQHTTTASRLYHFPHGGDVIDSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGE 320
Cdd:PRK12288 238 DNSGLGQHTTTAARLYHFPHGGDLIDSPGVREFGLWHLEPEQVTQGFVEFRDYLGTCKFRDCKHDDDPGCALREAVEEGK 317

                        330       340       350
                 ....*....|....*....|....*....|
gi 495778348 321 IAETRFENYHRILESMDQVKTRKNFSDSDN 350
Cdd:PRK12288 318 IAETRFENYHRILESMAEVKTRRHFSDTDD 347
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
41-342 1.39e-135

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 387.55  E-value: 1.39e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  41 EGVVISRFGMHADVESADGAIHRCNIRRTIR----SLVTGDRVVWRPGKEAaegvtvKGIVEAVHERTSVLTRPDFY-DG 115
Cdd:COG1162    3 PGRVIKVHGGRYYVETEDGERYRCRLRGKLRkkgiSPVVGDWVEIEPDDDG------EGVIEEILPRKNLLVRPAVGrDK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 116 VKPIAANINQIVIVSAIL-PELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDGMAfvnEQMDIYRKIGYRVLMVSSYT 194
Cdd:COG1162   77 EQVIAANIDQVLIVVALAePDFNLRLLDRYLVAAEAAGIEPVIVLNKADLADDEELE---ELLAIYEALGYPVLAVSAKT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 195 KDGLKPLEEALTDRISIFAGQSGVGK---------SSllnnllglqqEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVI 265
Cdd:COG1162  154 GEGLDELRELLKGKTSVLVGQSGVGKstlinallpDA----------DLATGEISEKLGRGRHTTTHAELYPLPGGGWLI 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495778348 266 DSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGEIAETRFENYHRILESMDQVKTR 342
Cdd:COG1162  224 DTPGFREFGLWHIEPEELAHYFPEFRELAGQCRFRDCTHLHEPGCAVKAAVEAGEISPERYESYLKLLEELEERKRR 300
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
 73-334 2.77e-115

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 334.00  E-value: 2.77e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348   73 LVTGDRVVWRPGKEaaegvtVKGIVEAVHERTSVLTRPdfydgvkpIAANINQIVIV-SAILPELSLNIIDRYLVACETL 151
Cdd:TIGR00157   1 LVVGDRVVWEPGNP------VKVYGGAIAERKNELTRP--------IVANIDQIVIVsSAVLPELSLNQLDRFLVVAEAQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  152 QVEPIIVLNKIDLLDDDGMAfvNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKSSLLNNLLGLQ 231
Cdd:TIGR00157  67 NIEPIIVLNKIDLLDDEDME--KEQLDIYRNIGYQVLMTSSKNQDGLKELIEALQNRISVFAGQSGVGKSSLINALDPSV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  232 QEIlTNDVSDVSGLGQHTTTASRLYHFpHGGDVIDSPGVREFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCA 311
Cdd:TIGR00157 145 KQQ-VNDISSKLGLGKHTTTHVELFHF-HGGLIADTPGFNEFGLWHLEPEQLTQGFVEFRDYLGLCKFRDCLHQSEPGCA 222

                         250       260
                  ....*....|....*....|...
gi 495778348  312 IREAVEKGEIAETRFENYHRILE 334
Cdd:TIGR00157 223 VRQAVEQGEISEWRYENYLKLIE 245
PRK00098 PRK00098
GTPase RsgA; Reviewed
 41-342 6.32e-104

GTPase RsgA; Reviewed


Pssm-ID: 234631 [Multi-domain]  Cd Length: 298  Bit Score: 307.13  E-value: 6.32e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  41 EGVVISRFGMHADVESADGAIHRCNIR-----RTIRSLVtGDRVVWRPGKEAaegvtvKGIVEAVHERTSVLTRPDFYDG 115
Cdd:PRK00098   2 EGLIIKALGGFYYVESEDGQVYQCRARgkfrkKTNTPAV-GDRVEFSAENND------EGVILEIHERKNLLVRPPIFKS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 116 vKPIAANINQIVIV-SAILPELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDdgMAFVNEQMDIYRKIGYRVLMVSSYT 194
Cdd:PRK00098  75 -KLIAANVDQAVLVfAAKEPDFSTDLLDRFLVLAEANGIKPIIVLNKIDLLDD--LEEARELLALYRAIGYDVLELSAKE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 195 KDGLKPLEEALTDRISIFAGQSGVGKSSLLNNLLGLQqEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVIDSPGVREFG 274
Cdd:PRK00098 152 GEGLDELKPLLAGKVTVLAGQSGVGKSTLLNALAPDL-ELKTGEISEALGRGKHTTTHVELYDLPGGGLLIDTPGFSSFG 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495778348 275 LWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGEIAETRFENYHRILESMDQVKTR 342
Cdd:PRK00098 231 LHDLEAEELEHYFPEFRPLSGDCKFRNCTHLHEPGCAVKAAVEEGEIAPSRYESYLQILEEIENRRER 298
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 121-334 1.77e-98

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 290.07  E-value: 1.77e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 121 ANINQIVIVSAIL-PELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDGMAfvnEQMDIYRKIGYRVLMVSSYTKDGLK 199
Cdd:cd01854    1 ANVDQVLIVFSLKePFFNLRLLDRYLVAAEASGIEPVIVLNKADLVDDEELE---ELLEIYEKLGYPVLAVSAKTGEGLD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 200 PLEEALTDRISIFAGQSGVGK---------SSllnnllglqqEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVIDSPGV 270
Cdd:cd01854   78 ELRELLKGKTSVLVGQSGVGKstllnallpEL----------VLATGEISEKLGRGRHTTTHRELFPLPGGGLIIDTPGF 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495778348 271 REFGLWHLEPEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGEIAETRFENYHRILE 334
Cdd:cd01854  148 RELGLLHIDPEELAEYFPEFEELAGQCRFRDCTHINEPGCAVKAAVEAGEISEERYESYLKLLE 211
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
 100-276 4.83e-74

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 226.65  E-value: 4.83e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  100 VHERTSVLTRPDFYDGvKPIAANINQIVIVSAIL-PELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDgmAFVNEQMD 178
Cdd:pfam03193   1 VLPRKNLLVRPPAGRR-QIIVANVDQAVIVFSLKePDFNLNLLDRFLVLAEASGIEPVIVLNKIDLLDEE--EELEELLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  179 IYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGKsSLLNNLLGLQQEILTNDVSDVSGLGQHTTTASRLYHF 258
Cdd:pfam03193  78 IYRAIGYPVLFVSAKTGEGIEALKELLKGKTTVLAGQSGVGK-STLLNALLPELDLRTGEISEKLGRGRHTTTHVELFPL 156

                         170
                  ....*....|....*...
gi 495778348  259 PHGGDVIDSPGVREFGLW 276
Cdd:pfam03193 157 PGGGLLIDTPGFRELGLW 174
PRK01889 PRK01889
GTPase RsgA; Reviewed
 75-333 1.78e-42

GTPase RsgA; Reviewed


Pssm-ID: 234988 [Multi-domain]  Cd Length: 356  Bit Score: 150.85  E-value: 1.78e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  75 TGDRVVWRPGKEAaegvtvkgIVEAVHERTSVLTRP---DFYDGvKPIAANINQIVIVSAILPELSLNIIDRYLV-ACET 150
Cdd:PRK01889  71 VGDWVLLDNEKKA--------RIVRLLPRRSLFSRKaagTRSEE-QLIAANVDTVFIVCSLNHDFNLRRIERYLAlAWES 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 151 lQVEPIIVLNKIDLLDDdgmafVNEQMDIYRKI--GYRVLMVSSYTKDGLKPLEEALTDRISI-FAGQSGVGKSSLLNNL 227
Cdd:PRK01889 142 -GAEPVIVLTKADLCED-----AEEKIAEVEALapGVPVLAVSALDGEGLDVLAAWLSGGKTVaLLGSSGVGKSTLVNAL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 228 LGLQqEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVIDSPGVREFGLWhlEPEQIFNG-FVEFHDYLGACKYRDCKHDN 306
Cdd:PRK01889 216 LGEE-VQKTGAVREDDSKGRHTTTHRELHPLPSGGLLIDTPGMRELQLW--DAEDGVEEtFSDIEELAAQCRFRDCAHEA 292

                        250       260
                 ....*....|....*....|....*..
gi 495778348 307 DPGCAIREAVEKGEIAETRFENYHRIL 333
Cdd:PRK01889 293 EPGCAVQAAIENGELDERRLQSYRKLQ 319
PRK12289 PRK12289
small ribosomal subunit biogenesis GTPase RsgA;
67-336 1.44e-36

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237040 [Multi-domain]  Cd Length: 352  Bit Score: 135.14  E-value: 1.44e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348  67 RRT----IRSLV-TGDRVVwrpgKEAAEGVTVKGIVEAVHERTSVLTRPdfydgvkPIAaNINQIVIVSAIL-PELSLNI 140
Cdd:PRK12289  41 RRTrlkkIGQQVmVGDRVI----VEEPDWQGQRGAIAEVLPRKTELDRP-------PVA-NADQILLVFALAePPLDPWQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 141 IDRYLVACETLQVEPIIVLNKIDLLDDDGMAFVNEQMdiyRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSGVGK 220
Cdd:PRK12289 109 LSRFLVKAESTGLEIVLCLNKADLVSPTEQQQWQDRL---QQWGYQPLFISVETGIGLEALLEQLRNKITVVAGPSGVGK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 221 sSLLNNLLGLQQEILTNDVSDVSGLGQHTTTASRLYHFPHGGDVIDSPGvreFGLWHL--EPEQIFNGFVEFHDYL--GA 296
Cdd:PRK12289 186 -SSLINRLIPDVELRVGKVSGKLGRGRHTTRHVELFELPNGGLLADTPG---FNQPDLdcSPRELAHYFPEARQRLaqGN 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 495778348 297 CKYRDCKHDNDPGCAIREAVEkgeiaetRFENYHRILESM 336
Cdd:PRK12289 262 CQFNDCLHRDEPNCAVRGDWE-------RYEHYLEFLEEA 294
S1_YloQ_GTPase cd04466
S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. ...
 41-109 4.08e-08

S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of three domains: an N-terminal S1 domain, a central GTPase domain, and a C-terminal zinc finger domain. This N-terminal S1 domain binds ssRNA. The central GTPase domain contains nucleotide-binding signature motifs: G1 (walker A), G3 (walker B) and G4 motifs. Experiments show that the bacterial YloQ and YjeQ proteins have low intrinsic GTPase activity. The C-terminal zinc-finger domain has structural similarity to a portion of the DNA-repair protein Rad51. This suggests a possible role for this GTPase as a regulator of translation, perhaps as a translation initiation factor. This family is classified based on the N-terminal S1 domain.


Pssm-ID: 239912 [Multi-domain]  Cd Length: 68  Bit Score: 49.48  E-value: 4.08e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495778348  41 EGVVISRFGMHADVESADGAIHRC----NIRRTIRSLVTGDRVVWRPGKEAaegvtvKGIVEAVHERTSVLTR 109
Cdd:cd04466    2 EGLIIKAIGGFYYVETEDGKIYECrlrgKFRKDKNPPAVGDRVEFEPEDDG------EGVIEEILPRKNLLIR 68
obgE PRK12299
GTPase CgtA; Reviewed
 156-210 2.03e-07

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 51.99  E-value: 2.03e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495778348 156 IIVLNKIDLLDDDGMAFvNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRIS 210
Cdd:PRK12299 275 ILVLNKIDLLDEEEERE-KRAALELAALGGPVFLISAVTGEGLDELLRALWELLE 328
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 129-209 3.60e-05

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 43.64  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 129 VSAILPELSLNIIDRylvaCETLQVepIIVLNKIDLLDDDGMAFVNEqmdiyrkiGYRVLMVSSYTKDGLKPLEEALTDR 208
Cdd:cd04164   92 ASEGLDEEDLEILEL----PAKKPV--IVVLNKSDLLSDAEGISELN--------GKPIIAISAKTGEGIDELKEALLEL 157


                 .
gi 495778348 209 I 209
Cdd:cd04164  158 A 158
GTP_EFTU pfam00009
Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in ...
 148-209 8.89e-05

Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.


Pssm-ID: 425418 [Multi-domain]  Cd Length: 187  Bit Score: 42.90  E-value: 8.89e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495778348  148 CETLQVEPIIVLNKIDLLDDDGMAFVNEQM--DIYRKIGYR-----VLMVSSYTKDGLKPLEEALTDRI 209
Cdd:pfam00009 117 ARQLGVPIIVFINKMDRVDGAELEEVVEEVsrELLEKYGEDgefvpVVPGSALKGEGVQTLLDALDEYL 185
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
 156-209 9.40e-05

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 42.83  E-value: 9.40e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495778348 156 IIVLNKIDLLDDDgmafvnEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRI 209
Cdd:cd01878  157 ILVLNKIDLLDDE------ELEERLRAGRPDAVFISAKTGEGLDLLKEAIEELL 204
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 156-208 1.14e-04

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 42.16  E-value: 1.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 495778348 156 IIVLNKIDLLDDDGmafVNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDR 208
Cdd:cd01897  116 IVVLNKIDLLTEED---LSEIEKELEKEGEEVIKISTLTEEGVDELKNKACEL 165
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 156-209 1.16e-04

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 42.03  E-value: 1.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 495778348 156 IIVLNKIDLLDDDGMAFVNEQMdIYRKIGYRVLMVSSYTKDGLKPLEEALTDRI 209
Cdd:cd01898  118 IVVLNKIDLLDAEERFEKLKEL-LKELKGKKVFPISALTGEGLDELLKKLAKLL 170
HflX COG2262
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]; ...
 156-210 1.23e-04

50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441863 [Multi-domain]  Cd Length: 419  Bit Score: 43.54  E-value: 1.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495778348 156 IIVLNKIDLLDDdgmafvnEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRIS 210
Cdd:COG2262  315 ILVFNKIDLLDD-------EELERLRAGYPDAVFISAKTGEGIDELLEAIEERLP 362
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
119-205 1.93e-04

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 42.40  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 119 IAANINQ----IVIVSAILPELSLN-IIDRyLVA---CetlqvepIIVLNKIDLLDDDgmafVNEQ-MDIYRKIGYRVLM 189
Cdd:COG1161   17 IKEILKLvdlvIEVVDARIPLSSRNpMLDE-LVGnkpR-------LLVLNKADLADPS----VTKQwLKYFEKQGVDALA 84

                         90
                 ....*....|....*.
gi 495778348 190 VSSYTKDGLKPLEEAL 205
Cdd:COG1161   85 ISAKKGKGIKELIEAI 100
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 156-217 2.75e-04

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 42.36  E-value: 2.75e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495778348 156 IIVLNKIDLLDDdgmafvnEQMDIYRKIGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSG 217
Cdd:COG0486  323 IVVLNKIDLPSE-------ADGELKSLPGEPVIAISAKTGEGIDELKEAILELVGEGALEGE 377
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 126-205 3.03e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 40.90  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 126 IVIVSAILPELSLNIIDRYLVACETLQVEPIIVLNKIDLLDDDGMAFVNEQMDIYRKIGYRVLMVSSYTKDGLKPLEEAL 205
Cdd:cd00882   80 LLVVDSTDRESEEDAKLLILRRLRKEGIPIILVGNKIDLLEEREVEELLRLEELAKILGVPVFEVSAKTGEGVDELFEKL 159
obgE PRK12296
GTPase CgtA; Reviewed
 156-210 4.81e-04

GTPase CgtA; Reviewed


Pssm-ID: 237045 [Multi-domain]  Cd Length: 500  Bit Score: 41.78  E-value: 4.81e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 495778348 156 IIVLNKIDLLDDDGMA-FVNEQMdiyRKIGYRVLMVSSYTKDGLKPLEEALTDRIS 210
Cdd:PRK12296 288 LVVLNKIDVPDARELAeFVRPEL---EARGWPVFEVSAASREGLRELSFALAELVE 340
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
156-210 6.33e-04

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 39.96  E-value: 6.33e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495778348 156 IIVLNKIDLLDDDGmafVNEQMDIYRKIG----YRVLMVSSYTKDGLKPLEEALTDRIS 210
Cdd:COG1100  115 ILVLNKIDLYDEEE---IEDEERLKEALSedniVEVVATSAKTGEGVEELFAALAEILR 170
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 141-209 1.03e-03

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 39.42  E-value: 1.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495778348 141 IDRYLVA-CETLQVEPIIVLNKIDLLDDDGMAFVNEQMDIY---RKIGYRVLMVSSYTKDGLKPLEEALTDRI 209
Cdd:cd01876   98 IDLEMLEfLEELGIPFLIVLTKADKLKKSELAKVLKKIKEElnlFNILPPVILFSSKKGTGIDELRALIAEWL 170
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
156-217 2.32e-03

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 39.71  E-value: 2.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495778348 156 IIVLNKIDLLDDDGMAFVNeqmdiyrkiGYRVLMVSSYTKDGLKPLEEALTDRISIFAGQSG 217
Cdd:PRK05291 325 IVVLNKADLTGEIDLEEEN---------GKPVIRISAKTGEGIDELREAIKELAFGGFGGNQ 377
obgE PRK12297
GTPase CgtA; Reviewed
 156-210 2.58e-03

GTPase CgtA; Reviewed


Pssm-ID: 237046 [Multi-domain]  Cd Length: 424  Bit Score: 39.31  E-value: 2.58e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 495778348 156 IIVLNKIDLLDDDgmafvnEQMDIYR-KIGYRVLMVSSYTKDGLKPLEEALTDRIS 210
Cdd:PRK12297 278 IVVANKMDLPEAE------ENLEEFKeKLGPKVFPISALTGQGLDELLYAVAELLE 327
PLN02219 PLN02219
probable galactinol--sucrose galactosyltransferase 2
 264-348 3.42e-03

probable galactinol--sucrose galactosyltransferase 2


Pssm-ID: 165863  Cd Length: 775  Bit Score: 39.22  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 264 VIDSPGVREFGLWHlePEQIFNGFVEFHDYLGACKYRDCKHDNDPGCAIREAVEKGEIAETRfeNYHRILESmdqvKTRK 343
Cdd:PLN02219 347 VMDSLSVHGLGLVN--PKKVFNFYNELHAYLASCGVDGVKVDVQNIIETLGAGHGGRVSLTR--SYQQALEA----SIAR 418


                 ....*
gi 495778348 344 NFSDS 348
Cdd:PLN02219 419 NFTDN 423
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 126-270 5.28e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 36.98  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778348 126 IVIVSAILPELSLNIIDRYLVacETLQVEPIIVLNKIDLLD-DDGMAFVNEQMDIYrkiGYRVLMVSSYTKDGLKPLEEA 204
Cdd:cd01849    4 VEVVDARDPLSSRNPDIEVLI--NEKNKKLIMVLNKADLVPkEVLRKWVAELSELY---GTKTFFISATNGQGILKLKAE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495778348 205 LTDRISI----------FAGQSGVGKSSLLNNllglqqeiLTNDVSDVSGLGQHTTTASRLYHFPHGGDVIDSPGV 270
Cdd:cd01849   79 ITKQKLKlkykkgirvgVVGLPNVGKSSFINA--------LLNKFKLKVGSIPGTTKLQQDVKLDKEIYLYDTPGI 146
SelB COG3276
Selenocysteine-specific translation elongation factor SelB [Translation, ribosomal structure ...
 145-205 6.66e-03

Selenocysteine-specific translation elongation factor SelB [Translation, ribosomal structure and biogenesis]; Selenocysteine-specific translation elongation factor SelB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 442507 [Multi-domain]  Cd Length: 630  Bit Score: 38.36  E-value: 6.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495778348 145 LVACETLQVEP-IIVLNKIDLLDDDGMAFVNEQM-DIYRKIGYR---VLMVSSYTKDGLKPLEEAL 205
Cdd:COG3276   96 LAILDLLGIKRgIVVLTKADLVDEEWLELVEEEIrELLAGTFLEdapIVPVSAVTGEGIDELRAAL 161
obgE PRK12298
GTPase CgtA; Reviewed
 156-209 9.55e-03

GTPase CgtA; Reviewed


Pssm-ID: 237047 [Multi-domain]  Cd Length: 390  Bit Score: 37.54  E-value: 9.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 495778348 156 IIVLNKIDLLDDDGMAfvnEQMDIYRK-IGY--RVLMVSSYTKDGLKPLEEALTDRI 209
Cdd:PRK12298 279 WLVFNKIDLLDEEEAE---ERAKAIVEaLGWegPVYLISAASGLGVKELCWDLMTFI 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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