|
Name |
Accession |
Description |
Interval |
E-value |
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
26-464 |
0e+00 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 662.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 26 QPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYI 105
Cdd:TIGR00665 1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 106 SQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIKDA 185
Cdd:TIGR00665 81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGDVEELLDEAEQKIFEIAESRTSKGFKSIKEILKEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 186 MEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVN 265
Cdd:TIGR00665 161 VEEIEELYERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLVM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 266 RLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNASG 345
Cdd:TIGR00665 241 RMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSGSG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 346 MNfGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITE 425
Cdd:TIGR00665 321 RS-ENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQRE---DKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDS 396
|
410 420 430
....*....|....*....|....*....|....*....
gi 496047901 426 DERGNsliglAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:TIGR00665 397 EDKGI-----AEIIIAKQRNGPTGTVKLAFLGEYTRFEN 430
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
31-466 |
0e+00 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 661.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 31 ELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYISQLTS 110
Cdd:COG0305 3 EAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 111 KVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIKDAMEMLQ 190
Cdd:COG0305 83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDEDVDELLDEAEQKIFEIAEKRSSKGFVSISDILKEALERIE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 191 KAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLIVN 270
Cdd:COG0305 163 ELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLLSS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 271 VCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNASGMNfGS 350
Cdd:COG0305 243 EARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRS-EN 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 351 REQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDERgn 430
Cdd:COG0305 322 RQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRT---DKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSEDK-- 396
|
410 420 430
....*....|....*....|....*....|....*.
gi 496047901 431 sliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVE 466
Cdd:COG0305 397 ---GIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
24-466 |
1.25e-177 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 506.41 E-value: 1.25e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 24 RLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPF 103
Cdd:PRK05748 8 RVPPQSIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEEVGGLS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 104 YISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIK 183
Cdd:PRK05748 88 YLAELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPEDDADEILDEAEKKIFEVSERRNKSGFKNIKDVLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 184 DAMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQL 263
Cdd:PRK05748 168 KAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVAIFSLEMGAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 264 VNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREH-GIKCIIIDYLQLMN 342
Cdd:PRK05748 248 VMRMLCAEGNIDAQRLRTGQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHgGLGLILIDYLQLIQ 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 343 ASGMNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYY- 421
Cdd:PRK05748 328 GSGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQ---DKRPVMSDIRESGSIEQDADIVAFLYRDDYYd 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 496047901 422 KITEDErgnsliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVE 466
Cdd:PRK05748 405 EETENK------NTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLA 443
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
201-464 |
1.41e-160 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 455.34 E-value: 1.41e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 201 GLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIK 280
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 281 SGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNaSGMNFGSREQEVSTISR 360
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMS-GGSRGENRQQEISEISR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 361 SLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDErgnsliGLAEIII 440
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRT---DKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPE------GKAEIII 230
|
250 260
....*....|....*....|....
gi 496047901 441 AKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:pfam03796 231 AKQRNGPTGTVKLAFLGEYTRFEN 254
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
201-464 |
1.15e-136 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 394.96 E-value: 1.15e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 201 GLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIK 280
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 281 SGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHG-IKCIIIDYLQLMNASGmNFGSREQEVSTIS 359
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGgLGLIVIDYLQLIRGSK-RAENRQQEVAEIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 360 RSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDERgnsliGLAEII 439
Cdd:cd00984 160 RSLKALAKELNVPVIALSQLNRGVESRT---DKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDK-----GIAEII 231
|
250 260
....*....|....*....|....*
gi 496047901 440 IAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:cd00984 232 IAKNRNGPTGTVYLAFNPEYTRFTD 256
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
26-464 |
0e+00 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 662.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 26 QPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYI 105
Cdd:TIGR00665 1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 106 SQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIKDA 185
Cdd:TIGR00665 81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGDVEELLDEAEQKIFEIAESRTSKGFKSIKEILKEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 186 MEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVN 265
Cdd:TIGR00665 161 VEEIEELYERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAEQLVM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 266 RLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNASG 345
Cdd:TIGR00665 241 RMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVIDYLQLMSGSG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 346 MNfGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITE 425
Cdd:TIGR00665 321 RS-ENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQRE---DKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPDS 396
|
410 420 430
....*....|....*....|....*....|....*....
gi 496047901 426 DERGNsliglAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:TIGR00665 397 EDKGI-----AEIIIAKQRNGPTGTVKLAFLGEYTRFEN 430
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
31-466 |
0e+00 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 661.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 31 ELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYISQLTS 110
Cdd:COG0305 3 EAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 111 KVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIKDAMEMLQ 190
Cdd:COG0305 83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDEDEDVDELLDEAEQKIFEIAEKRSSKGFVSISDILKEALERIE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 191 KAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLIVN 270
Cdd:COG0305 163 ELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLLSS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 271 VCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNASGMNfGS 350
Cdd:COG0305 243 EARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIVIDYLQLMSGSGRS-EN 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 351 REQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDERgn 430
Cdd:COG0305 322 RQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRT---DKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSEDK-- 396
|
410 420 430
....*....|....*....|....*....|....*.
gi 496047901 431 sliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVE 466
Cdd:COG0305 397 ---GIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
24-466 |
1.25e-177 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 506.41 E-value: 1.25e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 24 RLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPF 103
Cdd:PRK05748 8 RVPPQSIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEEVGGLS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 104 YISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIK 183
Cdd:PRK05748 88 YLAELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPEDDADEILDEAEKKIFEVSERRNKSGFKNIKDVLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 184 DAMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQL 263
Cdd:PRK05748 168 KAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVAIFSLEMGAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 264 VNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREH-GIKCIIIDYLQLMN 342
Cdd:PRK05748 248 VMRMLCAEGNIDAQRLRTGQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHgGLGLILIDYLQLIQ 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 343 ASGMNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYY- 421
Cdd:PRK05748 328 GSGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQ---DKRPVMSDIRESGSIEQDADIVAFLYRDDYYd 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 496047901 422 KITEDErgnsliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVE 466
Cdd:PRK05748 405 EETENK------NTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLA 443
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
201-464 |
1.41e-160 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 455.34 E-value: 1.41e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 201 GLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIK 280
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 281 SGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNaSGMNFGSREQEVSTISR 360
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMS-GGSRGENRQQEISEISR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 361 SLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDErgnsliGLAEIII 440
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRT---DKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPE------GKAEIII 230
|
250 260
....*....|....*....|....
gi 496047901 441 AKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:pfam03796 231 AKQRNGPTGTVKLAFLGEYTRFEN 254
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
19-408 |
3.32e-147 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 443.81 E-value: 3.32e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 19 LPDMGRLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELED 98
Cdd:PRK07773 17 SEDYGRQPPQDLAAEQSVLGGMLLSKEAIARVLERLRPGAFYRPAHQNIYDAILDLYGRGEPADLVTVAAELDRRGLLER 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 99 VGGPFYISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQI 178
Cdd:PRK07773 97 IGGAPYLHTLISTVPTAANADYYARIVAEKALLRRLIEAGTRIVQYGYAEGADVAEVVDRAQAEIYDVTDRRLSEDFVAL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 179 NPVIKDAMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEM 258
Cdd:PRK07773 177 EDLLQPTFDEIDAIASSGGLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEM 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 259 SNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYL 338
Cdd:PRK07773 257 SKEQLVMRLLSAEAKIKLSDMRSGRMSDDDWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQEANLGLIVVDYL 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 339 QLMNaSGMNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQD 408
Cdd:PRK07773 337 QLMT-SGKKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRT---DKRPMLSDLRESGCLTGD 402
|
|
| PRK09165 |
PRK09165 |
replicative DNA helicase; Provisional |
31-468 |
5.91e-141 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181676 [Multi-domain] Cd Length: 497 Bit Score: 415.05 E-value: 5.91e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 31 ELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDL---ALSQRPVdmlTVTEQLKKRGELEDVGGPFYISQ 107
Cdd:PRK09165 26 EAEQALLGAILINNRALDRVSDFLKPEHFFEPLHQRIYEAIAKIirkGKLATPV---TLKTFLENDEALGELGGVQYLAK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 108 LTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVE--DLMQEAEGKLFEI-SQRNVKKDVTQINPVIKD 184
Cdd:PRK09165 103 LATEAVTIINARDYGRIIYDLALRRELINIGEDVVNNAYDAPVDVApqEQIEDAEQKLYELaETGRYEGGFQSFGTAITE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 185 AMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNT--------------P 250
Cdd:PRK09165 183 AVDMANAAFKRDGHLSGISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALATNIAFNAAKAYRReaqpdgskkavnggV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 251 VALFSLEMSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGI 330
Cdd:PRK09165 263 VGFFSLEMSAEQLATRILSEQSEISSSKIRRGKISEEDFEKLVDASQELQKLPLYIDDTPALSISQLRARARRLKRQHGL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 331 KCIIIDYLQLMNASGMNFG-SREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARqgvEGKRPQLADLRESGAIEQDA 409
Cdd:PRK09165 343 DLLVVDYLQLIRGSSKRSSdNRVQEISEITQGLKALAKELNIPVIALSQLSRQVEQR---DDKRPQLSDLRESGSIEQDA 419
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496047901 410 DMVCFIHRPEYYK-------ITED-----ERGNSLIGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVEED 468
Cdd:PRK09165 420 DVVMFVYREEYYLkrkepreGTPKheewqEKMEKVHNKAEVIIAKQRHGPTGTVKLAFESEFTRFGDLADR 490
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
201-464 |
1.15e-136 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 394.96 E-value: 1.15e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 201 GLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIK 280
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 281 SGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHG-IKCIIIDYLQLMNASGmNFGSREQEVSTIS 359
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGgLGLIVIDYLQLIRGSK-RAENRQQEVAEIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 360 RSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDERgnsliGLAEII 439
Cdd:cd00984 160 RSLKALAKELNVPVIALSQLNRGVESRT---DKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDK-----GIAEII 231
|
250 260
....*....|....*....|....*
gi 496047901 440 IAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:cd00984 232 IAKNRNGPTGTVYLAFNPEYTRFTD 256
|
|
| PRK05595 |
PRK05595 |
replicative DNA helicase; Provisional |
24-466 |
1.35e-132 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235525 [Multi-domain] Cd Length: 444 Bit Score: 391.50 E-value: 1.35e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 24 RLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPF 103
Cdd:PRK05595 6 RSLPQSIEAEQSVLGAMIIDKTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLKSTDKLEAAGGVT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 104 YISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIK 183
Cdd:PRK05595 86 YITELSNSIVSTANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNNQDDVEKVIDSAEKKIFDISEKRTTSDFEPLSNVLE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 184 DAMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQL 263
Cdd:PRK05595 166 RGFEQIENLFNNKGETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSLEMSKEQL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 264 VNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMNA 343
Cdd:PRK05595 246 AYKLLCSEANVDMLRLRTGNLEDKDWENIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEHGIDMILIDYLQLMSG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 344 SGmNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYY-K 422
Cdd:PRK05595 326 GK-GSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRA---DHRPMLSDLRESGSIEQDADVVMFLYRDEYYnK 401
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 496047901 423 ITEDErgnsliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVE 466
Cdd:PRK05595 402 ETEDK------NVAECIIAKQRNGPTGTVKLAWLGQYSKFGNLD 439
|
|
| PRK08760 |
PRK08760 |
replicative DNA helicase; Provisional |
4-468 |
9.43e-130 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181547 [Multi-domain] Cd Length: 476 Bit Score: 385.42 E-value: 9.43e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 4 GTRNTGRGRKKPVEMLPDMGRLQ--PQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPV 81
Cdd:PRK08760 9 SNRNRDRDDDDYDRPEPRLDQLRvpPHSVEAEQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 82 DMLTVTEQLKKRGELEDVGGPFYISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFD-ETLDVEDLMQEAE 160
Cdd:PRK08760 89 DAVTLGEWFESQGKLEQVGDGAYLIELASTTPSAANIAAYAEIVRDKAVLRQLIEVGTTIVNDGFQpEGRESIELLASAE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 161 GKLFEISQRN--VKKDVTQINPVIKDAMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLS 238
Cdd:PRK08760 169 KAVFKIAEAGarGRTDFVAMPGALKDAFEELRNRFENGGNITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 239 MAKNMAVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELR 318
Cdd:PRK08760 249 IAEYAAIKSKKGVAVFSMEMSASQLAMRLISSNGRINAQRLRTGALEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLR 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 319 TKARRLVREHGIKCIIIDYLQLMNASGmNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLAD 398
Cdd:PRK08760 329 SKCRRLKREHDLGLIVIDYLQLMSVPG-NSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRT---DKRPVMAD 404
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 399 LRESGAIEQDADMVCFIHRPEYYkiteDERGNSLIGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVEED 468
Cdd:PRK08760 405 LRESGAIEQDADMIVFIYRDDYY----NKENSPDKGLAEIIIGKHRGGPTGSCKLKFFGEYTRFDNLAHD 470
|
|
| PRK08506 |
PRK08506 |
replicative DNA helicase; Provisional |
31-479 |
6.64e-126 |
|
replicative DNA helicase; Provisional
Pssm-ID: 236278 [Multi-domain] Cd Length: 472 Bit Score: 375.50 E-value: 6.64e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 31 ELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMltvtEQLKKRGELEDvggPFYISQLTS 110
Cdd:PRK08506 8 DIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDE----EFIRKKLPKDK---KIDEEILLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 111 KVASS--AHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIKDAMEM 188
Cdd:PRK08506 81 ILATNpiDNIEAYVEEIKEKSIKRELLSLANTIPEQAVEEDQKSSDILDEVERELYSITNGSNSEDFKDSKEVIESTMEH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 189 LQK-AALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNmAVNFNTPVALFSLEMSNVQLVNRL 267
Cdd:PRK08506 161 IKKqKRLGNKDIIGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALK-ALNQDKGVAFFSLEMPAEQLMLRM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 268 IVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREH-GIKCIIIDYLQLMNASGm 346
Cdd:PRK08506 240 LSAKTSIPLQNLRTGDLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHpEIGLAVIDYLQLMSGSG- 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 347 NFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARqgvEGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITED 426
Cdd:PRK08506 319 NFKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESR---ADKRPMLSDLRESGAIEQDADIILFVYRDDVYKEREE 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 427 ERG-----------------NSLIGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVEEDIAVREFSSTMN 479
Cdd:PRK08506 396 KEKekkakkegkeerrihfqNKSIEEAEIIIGKNRNGPTGTVKLRFQKEFTRFVDKPIESHYEEGEETKA 465
|
|
| PRK07004 |
PRK07004 |
replicative DNA helicase; Provisional |
24-464 |
2.29e-125 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235907 [Multi-domain] Cd Length: 460 Bit Score: 373.86 E-value: 2.29e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 24 RLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPF 103
Cdd:PRK07004 13 KVPPHSIEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVYEALTTSGKAEEVGGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 104 YISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFD-ETLDVEDLMQEAEGKLFEISQRNVK--KDVTQINP 180
Cdd:PRK07004 93 YLNALAQNTPSAANIRRYAEIVRDRAVLRRLVSVADEISADAFNpQGKEVRQLLDEAESKVFSIAEEGARgtQGFLEIGP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 181 VIKDAMEMLQKAaLQKEG---LSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLE 257
Cdd:PRK07004 173 LLTQVVERIDTL-YHTANpsdVTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEYGLPVAVFSME 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 258 MSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHG-IKCIIID 336
Cdd:PRK07004 252 MPGTQLAMRMLGSVGRLDQHRMRTGRLTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLARQCGkLGLIIID 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 337 YLQLMNASGMNfGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARqgvEGKRPQLADLRESGAIEQDADMVCFIH 416
Cdd:PRK07004 332 YLQLMSGSSQG-ENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQR---PNKRPVMSDLRESGAIEQDADVILFIY 407
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 496047901 417 RPEYYKITEDERGNsliglAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:PRK07004 408 RDEVYNPDSPDKGT-----AEIIIGKQRNGPIGPVRLTFLGQYTKFDN 450
|
|
| PRK05636 |
PRK05636 |
replicative DNA helicase; Provisional |
4-464 |
3.38e-121 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180177 [Multi-domain] Cd Length: 505 Bit Score: 364.55 E-value: 3.38e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 4 GTRNTGRGRKKPVEMLPDMgRLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDM 83
Cdd:PRK05636 49 GGDRRGFKRREESREYRDF-RQPPYDNEAEQGVLGAMLLSPDTVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 84 LTVTEQLKKRGELEDVGGPFYISQLTSKVASSAHIEYHARIIAQKYLARELISF-TAMIQ-GKAFDETLDVEDLMQEAEG 161
Cdd:PRK05636 128 VIVAGRLDRTNDLERVGGAPYLHTLIQSVPTAANARYYAEIVSEKAVLRRLVDAgTRVVQlGYEGDEGAEIDSVIDRAQQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 162 KLFEISQRNVKKDVTQINPVIKDAMEMLQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAK 241
Cdd:PRK05636 208 EVFAVSQKNQSEDYAVLADILDPTMDELEMLSSQGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMR 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 242 NMAVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKA 321
Cdd:PRK05636 288 SASIKHNKASVIFSLEMSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKA 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 322 RRLVREHGIKCIIIDYLQLMnASGMNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRE 401
Cdd:PRK05636 368 RRLKQKHDLKLIVVDYLQLM-SSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRT---DKRPQLADLRE 443
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496047901 402 SGAIEQDADMVCFIHRPEYYKiTEDERGnsliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:PRK05636 444 SGSLEQDADMVMLLYRPDSQD-KDDERA----GEADIILAKHRGGPIDTVQVAHQLHYSRFVD 501
|
|
| PRK08840 |
PRK08840 |
replicative DNA helicase; Provisional |
10-464 |
4.35e-118 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181562 [Multi-domain] Cd Length: 464 Bit Score: 355.45 E-value: 4.35e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 10 RGRKKPVEMLpDMGRLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQ 89
Cdd:PRK08840 5 RNRKIPDAQV-DAIKVPPHSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 90 LKKRGELEDVGGPFYISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFD-ETLDVEDLMQEAEGKLFEISQ 168
Cdd:PRK08840 84 LERREQLEDVGGFAYLADLAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGYDpQGRTSEDLLDMAESKVFAIAE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 169 RNVK-----KDVTQINPVIKDAMEMLQKAAlqKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNM 243
Cdd:PRK08840 164 ARTSenegpQNVDSILEKTLERIELLYKTP--QDGVTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 244 AVNFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAP-IFVDDTPSLSVFELRTKAR 322
Cdd:PRK08840 242 AMDQDKPVLIFSLEMPAEQLMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKnMYIDDSSGLTPTEVRSRAR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 323 RLVREH-GIKCIIIDYLQLMNASGMNfGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRE 401
Cdd:PRK08840 322 RIAREHgGLSMIMVDYLQLMRVPALS-DNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRA---DKRPVNSDLRE 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496047901 402 SGAIEQDADMVCFIHRPEYYkitedERGNSLIGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:PRK08840 398 SGSIEQDADLIMFIYRDEVY-----NPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFDN 455
|
|
| phage_DnaB |
TIGR03600 |
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ... |
31-455 |
1.25e-117 |
|
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]
Pssm-ID: 274672 [Multi-domain] Cd Length: 420 Bit Score: 352.48 E-value: 1.25e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 31 ELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYISQLTS 110
Cdd:TIGR03600 3 EAEQAVLGGLLLDNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVGGLAYLAEISN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 111 KVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFD-ETLDVEDLMQEAEGKLFEISQRNVKKDVTQ-INPVIKDAMEM 188
Cdd:TIGR03600 83 NTPSAANISSYARIVREKAKERKLIAACQRIITLACSpDGGTAEQKVEEAQAALLALTMSDGQEDGFVtFGEVLEDVVRD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 189 LQKAALQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRLI 268
Cdd:TIGR03600 163 LDKRFNPKGELTGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMSAEQLGERLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 269 VNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREH-GIKCIIIDYLQLMnaSGMN 347
Cdd:TIGR03600 243 ASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKgGLDLIVVDYIQLM--APAR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 348 FGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARqgvEGKRPQLADLRESGAIEQDADMVCFIHRPEYYKITEDE 427
Cdd:TIGR03600 321 GRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKR---TDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDAREPP 397
|
410 420
....*....|....*....|....*...
gi 496047901 428 RgnsliGLAEIIIAKHRNGAVGDVRLRF 455
Cdd:TIGR03600 398 A-----GIAELILAKNRHGPTGTVELLF 420
|
|
| PRK06321 |
PRK06321 |
replicative DNA helicase; Provisional |
27-464 |
6.74e-117 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180528 [Multi-domain] Cd Length: 472 Bit Score: 352.61 E-value: 6.74e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 27 PQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYIS 106
Cdd:PRK06321 17 PNSKESEMIVLGCMLTSVNYLNLAANQLQEDDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQLNVIGGPSYLI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 107 QLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINPVIK--- 183
Cdd:PRK06321 97 TLAEFAGTSAYIEEYAEIIRSKSILRKMIQTAKEIEKKALEEPKDVATALDEAQNLLFKISQTTNLAQYVLVADKLKglt 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 184 ------------DAMEMLQKAALQKE--GLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNT 249
Cdd:PRK06321 177 sskdkpfllqlqERQEAFQQSAQGDSspMISGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCFQNRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 250 PVALFSLEMSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHG 329
Cdd:PRK06321 257 PVGIFSLEMTVDQLIHRIICSRSEVESKKISVGDLSGRDFQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRMKESYD 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 330 IKCIIIDYLQLMNASGMNFG--SREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARqgvEGKRPQLADLRESGAIEQ 407
Cdd:PRK06321 337 IQFLIIDYLQLLSGSGNLRNseSRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDR---ANHRPMMSDLRESGSIEQ 413
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 496047901 408 DADMVCFIHRPEYYKitederGNSLIGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:PRK06321 414 DSDLVMFLLRREYYD------PNDKPGTAELIVAKNRHGSIGSVPLVFEKEFARFRN 464
|
|
| PRK08006 |
PRK08006 |
replicative DNA helicase DnaB; |
10-464 |
3.57e-115 |
|
replicative DNA helicase DnaB;
Pssm-ID: 181193 [Multi-domain] Cd Length: 471 Bit Score: 348.15 E-value: 3.57e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 10 RGRKKPVEMLpdmgRLQPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQ 89
Cdd:PRK08006 15 RERDPQVAGL----KVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAES 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 90 LKKRGELEDVGGPFYISQLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFD-ETLDVEDLMQEAEGKLFEISQ 168
Cdd:PRK08006 91 LERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGYDpQGRTSEDLLDLAESRVFQIAE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 169 RNVKKD--VTQINPVIKDAMEMLQKAALQ-KEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAV 245
Cdd:PRK08006 171 SRANKDegPKNIADILDATVARIEQLFQQpHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 246 NFNTPVALFSLEMSNVQLVNRLIVNVCEIPGEKIKSGRLESYEWEQLDFKIKELYDA-PIFVDDTPSLSVFELRTKARRL 324
Cdd:PRK08006 251 LQDKPVLIFSLEMPGEQIMMRMLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKrNMYIDDSSGLTPTEVRSRARRI 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 325 VREH-GIKCIIIDYLQLMNASGMNfGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESG 403
Cdd:PRK08006 331 FREHgGLSLIMIDYLQLMRVPSLS-DNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRA---DKRPVNSDLRESG 406
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496047901 404 AIEQDADMVCFIHRPEYYKITEDERgnsliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:PRK08006 407 SIEQDADLIMFIYRDEVYHENSDLK-----GIAEIIIGKQRNGPIGTVRLTFNGQWSRFDN 462
|
|
| PRK06904 |
PRK06904 |
replicative DNA helicase; Validated |
27-467 |
5.43e-112 |
|
replicative DNA helicase; Validated
Pssm-ID: 136106 [Multi-domain] Cd Length: 472 Bit Score: 340.05 E-value: 5.43e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 27 PQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYIS 106
Cdd:PRK06904 24 PHSIEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLLTLDQALKTKGKSDEVGGFAYLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 107 QLTSKVASSAHIEYHARIIAQKYLARELISFTAMIQGKAFD-ETLDVEDLMQEAEGKLFEISQRNVK-----KDVTQINP 180
Cdd:PRK06904 104 ELSNNTPSAANILAYADIVREKAILRELISVGNNIAKNAYSpKGQDIKDILDEAERDVFSIAEKRTTanegpQNVINLLE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 181 VIKDAMEMLQKAAlQKEGLSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSN 260
Cdd:PRK06904 184 NTIDKIENLAATP-TNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMASEKPVLVFSLEMPA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 261 VQLVNRLIVNVCEIPGEKIKSGR-LESYEWEQLDFKIKELYDAP-IFVDDTPSLSVFELRTKARRLVREH-GIKCIIIDY 337
Cdd:PRK06904 263 EQIMMRMLASLSRVDQTKIRTGQnLDQQDWAKISSTVGMFKQKPnLYIDDSSGLTPTELRSRARRVYRENgGLSLIMVDY 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 338 LQLMNASGMNfGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHR 417
Cdd:PRK06904 343 LQLMRAPGFE-DNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRG---DKRPVNSDLRESGSIEQDADLIMFIYR 418
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 496047901 418 PE-YYKITEDERgnsliGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVEE 467
Cdd:PRK06904 419 DEvYNETTEDNK-----GVAEIIIGKQRNGPIGRVRLAFQGQYSRFDNLAN 464
|
|
| PRK06749 |
PRK06749 |
replicative DNA helicase; Provisional |
28-466 |
4.86e-84 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168658 [Multi-domain] Cd Length: 428 Bit Score: 266.43 E-value: 4.86e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 28 QARELEEAVLGALMLEKDaysIVSEI-LKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKrGELEDVGGPFYIS 106
Cdd:PRK06749 4 QNVEAEKTVLGSLLLDGE---LIKECrLTEQYFSMPVHKSIFQLMRKMEDEGQPIDLVTFTSRVDP-NFLKGIGGMEYFI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 107 QLTSKVASSAHIEYHARIIAQKYLARElisftAMIQGKAFDETLDVEDLMQEAEGKLFEISQRNVKKDVTQINpvIKDAM 186
Cdd:PRK06749 80 GLMDGVPTTSNFSYYEGLVRGAWKMYQ-----AGVLGHKMGERLIAEKSEKIIGETITALCELEEKDCVCEFD--LKDAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 187 EMLQKAALQKEG-LSGLRTGFEGLDKMTSGWQNSDLIIIAARPAMGKTAFVLSMAKNmAVNFNTPVALFSLEMSNVQLVN 265
Cdd:PRK06749 153 VDLYEELHQDAKeITGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLH-AAKSGAAVGLFSLEMSSKQLLK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 266 RLIVNVCEIPGEKIKS--GRLESYEWEQLDFKIKELYDAPIFVDDTPSLSVFELRTKARRLVREHGIK--CIIIDYLQLM 341
Cdd:PRK06749 232 RMASCVGEVSGGRLKNpkHRFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKkiLIIVDYLQLI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 342 NASGMNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGVEARQgveGKRPQLADLRESGAIEQDADMVCFIHRPEYY 421
Cdd:PRK06749 312 TGDPKHKGNRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQ---DKRPLLSDLRETGQIEQDADVIMLMYREDYY 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 496047901 422 -KITEDERgnsligLAEIIIAKHRNGAVGDVRLRFKSEFAKFMNVE 466
Cdd:PRK06749 389 dKETMQKE------MTEIHVAKHRNGPVGSFKLRFLKEFGRFVEGG 428
|
|
| DnaB |
pfam00772 |
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
26-127 |
1.11e-33 |
|
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.
Pssm-ID: 395624 [Multi-domain] Cd Length: 103 Bit Score: 122.73 E-value: 1.11e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 26 QPQARELEEAVLGALMLEKDAYSIVSEILKPECFYEKAHEKIYAAIVDLALSQRPVDMLTVTEQLKKRGELEDVGGPFYI 105
Cdd:pfam00772 2 PPHNIEAEQAVLGALLLDPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVGGIAYL 81
|
90 100
....*....|....*....|..
gi 496047901 106 SQLTSKVASSAHIEYHARIIAQ 127
Cdd:pfam00772 82 AELAANVPSAANIEYYARIVKE 103
|
|
| RecA-like_Gp4D_helicase |
cd19483 |
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ... |
222-412 |
1.46e-21 |
|
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410891 [Multi-domain] Cd Length: 231 Bit Score: 93.40 E-value: 1.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 222 IIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVNRL---IVNVCEIPGEKiksgrLESYEWEQLDFKIKE 298
Cdd:cd19483 1 VTIGAGSGIGKSTIVRELAYHLITEHGEKVGIISLEESVEETAKGLagkHLGKPEPLELP-----RDDITEEEEDDAFDN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 299 LYDAP--IFVDDTPSLSVFELRTKARRLVREHGIKCIIIDYLQLMnASGMNFGSREQEVSTISRSLKGLAKELNIPIIAL 376
Cdd:cd19483 76 ELGSGrfFLYDHFGSLDWDNLKEKIRYMVKVLGCKVIVLDHLTIL-VSGLDSSDERKELDEIMTELAALVKELGVTIILV 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 496047901 377 SQLNRgVEARQGVE-GKRPQLADLRESGAIEQDADMV 412
Cdd:cd19483 155 SHLRR-PGGGKGHEeGGEVSESDLRGSSAIAQLSDYV 190
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
404-464 |
1.03e-15 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 80.18 E-value: 1.03e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496047901 404 AIEQDADMVCFIHRPEYYkitedERGNSLIGLAEIIIAKHRNGAVGDVRLRFKSEFAKFMN 464
Cdd:PRK07773 827 SIEQDADVVILLYRPDYY-----DRDDPRGGEAEFIVAKHRNGPTGTVTLAFQLHLSRFAN 882
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
202-455 |
8.32e-08 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 53.00 E-value: 8.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 202 LRTGFEGLDKMTSG--WQNSdLIIIAARPAMGKTAFVLSMAKNMAVNfNTPVALFSLEMSNVQLVNRLivnvceipgeki 279
Cdd:COG0467 2 VPTGIPGLDELLGGglPRGS-STLLSGPPGTGKTTLALQFLAEGLRR-GEKGLYVSFEESPEQLLRRA------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 280 ksgrlesyewEQLDFKIKELYDAP--IFVDDTPS---LSVFELRTKARRLVREHGIKCIIIDylqlmNASGM-NFGSREQ 353
Cdd:COG0467 68 ----------ESLGLDLEEYIESGllRIIDLSPEelgLDLEELLARLREAVEEFGAKRVVID-----SLSGLlLALPDPE 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 354 EVSTISRSLKGLAKELNIPIIALSQLnrgvearqgvegkrPQLADLRESGAIEQDADMVCFIHrpeyYKITEDERGNSli 433
Cdd:COG0467 133 RLREFLHRLLRYLKKRGVTTLLTSET--------------GGLEDEATEGGLSYLADGVILLR----YVELGGELRRA-- 192
|
250 260
....*....|....*....|..
gi 496047901 434 glaeIIIAKHRNGAVGDVRLRF 455
Cdd:COG0467 193 ----LSVLKMRGSAHDRTIREF 210
|
|
| 41 |
PHA02542 |
41 helicase; Provisional |
209-415 |
1.14e-06 |
|
41 helicase; Provisional
Pssm-ID: 222864 [Multi-domain] Cd Length: 473 Bit Score: 50.83 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 209 LDKMTSG-WQNSDLIIIAARPAMGKTAFVLSMAKN-MAVNFNtpVALFSLEMSNVQLVNRLIVNVCEIPGEKIKSgrLES 286
Cdd:PHA02542 179 LNKITKGgAERKTLNVLLAGVNVGKSLGLCSLAADyLQQGYN--VLYISMEMAEEVIAKRIDANLLDVSLDDIDD--LSK 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 287 YEWEQLDFKIKELYDAPIFVDDTPSLSV----FelrtkaRRLVREHGIK------CIIIDYLQLMNASGMNFGSREQE-- 354
Cdd:PHA02542 255 AEYKAKMEKLRSKTQGKLIIKQYPTGGAhaghF------RALLNELKLKknfkpdVIIVDYLGICASSRLRVSSENSYty 328
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496047901 355 VSTISRSLKGLAKELNIPIIALSQLNRGvearqGVEGKRPQLADLRESGAIEQDAD-MVCFI 415
Cdd:PHA02542 329 VKAIAEELRGLAVEHDVVVWTAAQTTRS-----GWDSSDVDMSDTAESAGLPATADfMLAVI 385
|
|
| PRK05973 |
PRK05973 |
replicative DNA helicase; Provisional |
220-400 |
3.52e-06 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168322 [Multi-domain] Cd Length: 237 Bit Score: 48.11 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 220 DLIIIAARPAMGKTAFVLSMAKNmAVNFNTPVALFSLEMSNVQLVNRLivnvceipgEKIKSGRlesyeweqldfkikEL 299
Cdd:PRK05973 65 DLVLLGARPGHGKTLLGLELAVE-AMKSGRTGVFFTLEYTEQDVRDRL---------RALGADR--------------AQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 300 YDAPIFVDDTPSLSVFELrtkARRLVREHGIKCIIIDYLQLMNAsgmnfgSREQ-EVSTISRSLKGLAKELNIPIIALSQ 378
Cdd:PRK05973 121 FADLFEFDTSDAICADYI---IARLASAPRGTLVVIDYLQLLDQ------RREKpDLSVQVRALKSFARERGLIIVFISQ 191
|
170 180
....*....|....*....|...
gi 496047901 379 LNRGVEArqgvEGKR-PQLADLR 400
Cdd:PRK05973 192 IDRSFDP----SAKPlPDIRDVR 210
|
|
| RecA-like_superfamily |
cd01120 |
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ... |
317-406 |
1.72e-04 |
|
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410865 [Multi-domain] Cd Length: 119 Bit Score: 41.33 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 317 LRTKARRLVREHGIKCIIIDYLQLMNASGMnfGSREQEVSTISRSLKGLAKELNIPIIALSQLnrgveaRQGVEGKRPQL 396
Cdd:cd01120 38 ILEAIEDLIEEKKLDIIIIDSLSSLARASQ--GDRSSELLEDLAKLLRAARNTGITVIATIHS------DKFDIDRGGSS 109
|
90
....*....|
gi 496047901 397 ADLRESGAIE 406
Cdd:cd01120 110 NDERLLKSLR 119
|
|
| ATPase |
pfam06745 |
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ... |
202-390 |
3.08e-04 |
|
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.
Pssm-ID: 429095 [Multi-domain] Cd Length: 231 Bit Score: 42.23 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 202 LRTGFEGLDKMTSGW--QNSdLIIIAARPAMGKTAFVLSMAKNMAVNFNTPVALFSLEMSNVQLVnrlivnvceipgEKI 279
Cdd:pfam06745 1 VKTGIPGLDEILKGGfpEGR-VVLITGGPGTGKTIFGLQFLYNGALKYGEPGVFVTLEEPPEDLR------------ENA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 280 KS-GR-LESYEWEQLdFKIKELYDAPI-FVDDTPSLSVFELRTKARRLVREHGIKCIIIDylqlmNASGMNFGSREQEVS 356
Cdd:pfam06745 68 RSfGWdLEKLEEEGK-LAIIDASTSGIgIAEVEDRFDLEELIERLREAIREIGAKRVVID-----SITTLFYLLKPAVAR 141
|
170 180 190
....*....|....*....|....*....|....*.
gi 496047901 357 TISRSLKGLAKELNIPIIALSQLNRGVEA--RQGVE 390
Cdd:pfam06745 142 EILRRLKRVLKGLGVTAIFTSEKPSGEGGigGYGVE 177
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
316-399 |
4.09e-04 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 41.92 E-value: 4.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496047901 316 ELRTKARRL---VREHGIKCIIID-----YLQLMNASGMNFGSREQEVSTISRSLKGLAKELNIPIIALSQLNRGV-EAR 386
Cdd:cd19493 101 QLLERLPNLeehILSSGVRLVVIDsiaalVRREFGGSDGEVTERHNALAREASSLKRLAEEFRIAVLVTNQATTHFgDAG 180
|
90
....*....|...
gi 496047901 387 QGVEGKRPQLADL 399
Cdd:cd19493 181 DGSSGVTAALGDA 193
|
|
| |
